JP2014521313A5 - - Google Patents

Info

Publication number

JP2014521313A5

JP2014521313A5 JP2014519454A JP2014519454A JP2014521313A5 JP 2014521313 A5 JP2014521313 A5 JP 2014521313A5 JP 2014519454 A JP2014519454 A JP 2014519454A JP 2014519454 A JP2014519454 A JP 2014519454A JP 2014521313 A5 JP2014521313 A5 JP 2014521313A5

Authority

JP

Japan

Prior art keywords

seq

antibody

antigen

cells

binding fragment

Prior art date

2012-07-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108091033319 polynucleotide Proteins 0.000 claims description 13
• 102000040430 polynucleotide Human genes 0.000 claims description 13
• 239000002157 polynucleotide Substances 0.000 claims description 13
• 239000012634 fragment Substances 0.000 claims description 12
• 239000000427 antigen Substances 0.000 claims description 10
• 108091007433 antigens Proteins 0.000 claims description 10
• 102000036639 antigens Human genes 0.000 claims description 10
• 241000588724 Escherichia coli Species 0.000 claims description 5
• 108090000623 proteins and genes Proteins 0.000 claims description 5
• 101150081864 Spr gene Proteins 0.000 claims description 3
• 230000000694 effects Effects 0.000 claims description 3
• 230000035772 mutation Effects 0.000 claims description 3
• 150000007523 nucleic acids Chemical class 0.000 claims description 2
• 210000004027 cell Anatomy 0.000 claims 14
• 238000000034 method Methods 0.000 claims 6
• 235000001014 amino acid Nutrition 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 239000013604 expression vector Substances 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 239000012636 effector Substances 0.000 claims 2
• 239000001963 growth medium Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
• 101150052672 IGS1 gene Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229940034982 antineoplastic agent Drugs 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 235000018417 cysteine Nutrition 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 229920001427 mPEG Polymers 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 210000001322 periplasm Anatomy 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 125000006853 reporter group Chemical group 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108700012359 toxins Proteins 0.000 claims 1
• 238000011144 upstream manufacturing Methods 0.000 claims 1
• 241001302584 Escherichia coli str. K-12 substr. W3110 Species 0.000 description 2
• 108010078959 C-terminal processing peptidase Proteins 0.000 description 1
• 108091028043 Nucleic acid sequence Proteins 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1