JP2008507253A5 - - Google Patents

Info

Publication number

JP2008507253A5

JP2008507253A5 JP2006551695A JP2006551695A JP2008507253A5 JP 2008507253 A5 JP2008507253 A5 JP 2008507253A5 JP 2006551695 A JP2006551695 A JP 2006551695A JP 2006551695 A JP2006551695 A JP 2006551695A JP 2008507253 A5 JP2008507253 A5 JP 2008507253A5

Authority

JP

Japan

Prior art keywords

humanized antibody

antibody

seq

composition

fragment

Prior art date

2005-02-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 22
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 19
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 19
• 108020004414 DNA Proteins 0.000 claims description 17
• 239000012634 fragment Substances 0.000 claims description 13
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 10
• 102000053602 DNA Human genes 0.000 claims description 8
• 210000004027 cell Anatomy 0.000 claims description 6
• 239000000427 antigen Substances 0.000 claims description 4
• 102000036639 antigens Human genes 0.000 claims description 4
• 108091007433 antigens Proteins 0.000 claims description 4
• 238000012217 deletion Methods 0.000 claims description 4
• 230000037430 deletion Effects 0.000 claims description 4
• 239000013604 expression vector Substances 0.000 claims description 4
• 238000006467 substitution reaction Methods 0.000 claims description 4
• 239000002773 nucleotide Substances 0.000 claims description 3
• 125000003729 nucleotide group Chemical group 0.000 claims description 3
• 239000000203 mixture Substances 0.000 claims 20
• 241001529936 Murinae Species 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 6
• 125000000539 amino acid group Chemical group 0.000 claims 5
• 210000004408 hybridoma Anatomy 0.000 claims 5
• 102000004190 Enzymes Human genes 0.000 claims 4
• 108090000790 Enzymes Proteins 0.000 claims 4
• 241000124008 Mammalia Species 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000012636 effector Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
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• 238000007792 addition Methods 0.000 claims 1
• 230000006229 amino acid addition Effects 0.000 claims 1
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• 239000002532 enzyme inhibitor Substances 0.000 claims 1
• 229940125532 enzyme inhibitor Drugs 0.000 claims 1
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• 239000003446 ligand Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
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