JP2014521076A5 - - Google Patents
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- Publication number
- JP2014521076A5 JP2014521076A5 JP2014519460A JP2014519460A JP2014521076A5 JP 2014521076 A5 JP2014521076 A5 JP 2014521076A5 JP 2014519460 A JP2014519460 A JP 2014519460A JP 2014519460 A JP2014519460 A JP 2014519460A JP 2014521076 A5 JP2014521076 A5 JP 2014521076A5
- Authority
- JP
- Japan
- Prior art keywords
- column
- cation exchanger
- compound
- eluate
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001768 cations Chemical class 0.000 claims description 31
- 239000002738 chelating agent Substances 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 19
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 16
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 16
- 239000011707 mineral Substances 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 150000002500 ions Chemical class 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 11
- -1 ammonium ions Chemical class 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 8
- 230000002378 acidificating effect Effects 0.000 claims description 7
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims description 6
- 238000010828 elution Methods 0.000 claims description 6
- 230000008016 vaporization Effects 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 5
- 230000009918 complex formation Effects 0.000 claims description 5
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims description 5
- 238000009834 vaporization Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 11
- BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 claims 8
- 230000002285 radioactive effect Effects 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 229910052765 Lutetium Inorganic materials 0.000 claims 3
- 239000003729 cation exchange resin Substances 0.000 claims 3
- 150000007513 acids Chemical class 0.000 claims 2
- 229940023913 cation exchange resins Drugs 0.000 claims 2
- OHSVLFRHMCKCQY-UHFFFAOYSA-N lutetium atom Chemical compound [Lu] OHSVLFRHMCKCQY-UHFFFAOYSA-N 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
- 230000005526 G1 to G0 transition Effects 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 238000005277 cation exchange chromatography Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 229920000620 organic polymer Polymers 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
- 150000004760 silicates Chemical class 0.000 claims 1
- DBXBTMSZEOQQDU-UHFFFAOYSA-N 3-hydroxyisobutyric acid Chemical compound OCC(C)C(O)=O DBXBTMSZEOQQDU-UHFFFAOYSA-N 0.000 description 1
- 241000736892 Thujopsis dolabrata Species 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011051868.1 | 2011-07-15 | ||
| DE102011051868A DE102011051868B4 (de) | 2011-07-15 | 2011-07-15 | Verfahren zur Herstellung trägerfreier hochreiner 177Lu-Verbindungen sowie trägerfreie 177Lu-Verbindungen |
| PCT/EP2012/056644 WO2013010686A1 (de) | 2011-07-15 | 2012-04-12 | Verfahren zur herstellung trägerfreier hochreiner 177lu-verbindungen sowie trägerfreie 177lu-verbindungen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017090065A Division JP6530007B2 (ja) | 2011-07-15 | 2017-04-28 | 担体無添加（１７７）Ｌｕ化合物を含有する放射性医薬品 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014521076A JP2014521076A (ja) | 2014-08-25 |
| JP2014521076A5 true JP2014521076A5 (cg-RX-API-DMAC7.html) | 2015-05-14 |
| JP6219276B2 JP6219276B2 (ja) | 2017-10-25 |
Family
ID=46000806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519460A Active JP6219276B2 (ja) | 2011-07-15 | 2012-04-12 | 担体無添加高純度（１７７）Ｌｕ化合物の製造方法およびシステム |
| JP2017090065A Active JP6530007B2 (ja) | 2011-07-15 | 2017-04-28 | 担体無添加（１７７）Ｌｕ化合物を含有する放射性医薬品 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017090065A Active JP6530007B2 (ja) | 2011-07-15 | 2017-04-28 | 担体無添加（１７７）Ｌｕ化合物を含有する放射性医薬品 |
Country Status (20)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015289483B2 (en) * | 2014-07-18 | 2020-02-20 | Purdue Research Foundation | Ligand-assisted chromatography for metal ion separation |
| CN105063382B (zh) * | 2015-09-12 | 2017-06-13 | 北京科技大学 | 一种La、Ce、Pr、Nd混合稀土离子的分离方法 |
| US10344314B2 (en) * | 2016-05-04 | 2019-07-09 | Curium Us Llc | Systems and methods for sterility testing of radionuclide generator column assemblies |
| WO2017192191A2 (en) * | 2016-05-04 | 2017-11-09 | Mallinckrodt Nuclear Medicine Llc | Column assembly transfer mechanism and systems and methods for sanitizing same |
| AU2020266482A1 (en) * | 2019-04-29 | 2021-10-07 | Syngenta Crop Protection Ag | Compositions and methods for protein detection |
| CA3149552A1 (en) | 2019-08-29 | 2021-03-11 | Laura Katherine Sinclair | Systems and methods for selective recovery of metals from ion exchange resins |
| JP2022553073A (ja) | 2019-10-25 | 2022-12-21 | インテレクソン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 治療・診断標的としてのｈｌａ－ｈ， ｈｌａ－ｊおよびｈｌａ－ｌ |
| CN115380007A (zh) | 2019-11-20 | 2022-11-22 | 阳光科技公司 | 稀土元素的分离 |
| CN110828020A (zh) * | 2019-11-21 | 2020-02-21 | 中国核动力研究设计院 | 一种含有载体氯化镥-177溶液的制备系统及其制备方法 |
| WO2021123036A1 (en) | 2019-12-20 | 2021-06-24 | Nuclear Research And Consultancy Group | Chromatographic separation of metals using dota-based chelators |
| WO2021202914A1 (en) | 2020-04-02 | 2021-10-07 | SHINE Medical Technologies, LLC | Separation of rare earth elements |
| CN111440947B (zh) * | 2020-04-17 | 2022-02-15 | 包头稀土研究院 | 采用氧化镱原料还原蒸馏制备金属镱的方法 |
| RU2741009C9 (ru) * | 2020-09-11 | 2021-06-22 | Линчевский Дмитрий Александрович | Способ разделения лютеция и иттербия методом хроматографии |
| CN112176193B (zh) * | 2020-09-29 | 2022-08-09 | 中国工程物理研究院核物理与化学研究所 | 一种镧系树脂循环洗脱分离Yb-176和Lu-177的方法 |
| KR102266273B1 (ko) * | 2020-12-24 | 2021-06-17 | 한국원자력연구원 | 크로마토그래피를 이용한 무담체 루테튬-177의 생산 및 정제 방법 |
| DE102021109246B3 (de) | 2021-04-13 | 2022-06-09 | ITM Isotope Technologies Munich SE | Radiopharmaka zu unterschiedlichen ARTs |
| CN115216652A (zh) * | 2021-04-20 | 2022-10-21 | 赣江中药创新中心 | 一种从镱镥混合物中分离提纯镥的方法 |
| RU2763745C1 (ru) * | 2021-06-02 | 2022-01-10 | Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" | Способ катионообменного выделения радионуклида лютеция-177 из облученного в ядерном реакторе иттербия |
| US12090215B2 (en) | 2022-02-04 | 2024-09-17 | Westinghouse Electric Company Llc | Method and device for direct production of radio-isotope based cancer treatment pharmaceuticals |
| US20240035118A1 (en) * | 2022-07-26 | 2024-02-01 | Shine Technologies, Llc | Phase Change System and Phase Change Crucible for the Separation of Rare Earth Elements |
| US11894156B1 (en) * | 2023-04-04 | 2024-02-06 | CVF International LLC | Separation of rare earth elements by means of physical chemistry for use in medical applications |
| US20240339233A1 (en) | 2023-04-04 | 2024-10-10 | CVF International LLC | Separation of rare earth elements by means of physical chemistry |
| CN117018864A (zh) * | 2023-07-27 | 2023-11-10 | 中国核动力研究设计院 | 一种多级连续分离纯化制备无载体镥-177的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2925431A (en) | 1956-04-17 | 1960-02-16 | Gregory R Choppin | Cationic exchange process for the separation of rare earths |
| US3228750A (en) | 1962-06-07 | 1966-01-11 | Roald E Lindstrom | Process for separating rare-earth elements by ion exchange |
| JPS5845341A (ja) * | 1981-09-11 | 1983-03-16 | Agency Of Ind Science & Technol | 希土類金属の分離方法 |
| JPS62145164A (ja) * | 1985-12-19 | 1987-06-29 | Seitetsu Kagaku Co Ltd | 希土類イオンの分離法 |
| JPS63103825A (ja) * | 1986-10-17 | 1988-05-09 | Showa Denko Kk | 希土類元素の分離方法 |
| JPH03108661A (ja) * | 1989-09-22 | 1991-05-08 | Kurita Water Ind Ltd | 核酸関連物質の分離方法 |
| CN1054644C (zh) | 1995-11-08 | 2000-07-19 | 北京大学 | 铥、镱、镥的溶剂萃取分离方法 |
| FI991197A0 (fi) * | 1999-05-27 | 1999-05-27 | Mart Saarma | Neurotrooppiset tekijät lantionalueen ääreishermoston toimintahäiriön hoitamisessa |
| US6751280B2 (en) * | 2002-08-12 | 2004-06-15 | Ut-Battelle, Llc | Method of preparing high specific activity platinum-195m |
| US6716353B1 (en) * | 2002-10-30 | 2004-04-06 | Ut-Battelle, Llc | Method for preparing high specific activity 177Lu |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| EP1807844B1 (en) * | 2004-09-28 | 2010-05-19 | Soreq Nuclear Research Center Israel Atomic Energy Commission | Method and system for production of radioisotopes |
| CN1796608A (zh) | 2004-12-21 | 2006-07-05 | 北京大学 | 一种纯化镱和富集铥镥的方法及设备 |
| US9202600B2 (en) * | 2005-01-14 | 2015-12-01 | Paul Scherrer Institut | Method for production of radioisotope preparations and their use in life science, research, medical application and industry |
| WO2009140599A1 (en) * | 2008-05-15 | 2009-11-19 | Transmolecular, Inc. | Treatment of metastatic tumors |
| RU2404922C2 (ru) * | 2008-08-07 | 2010-11-27 | Открытое акционерное общество "Государственный научный центр Научно-иследовательский институт атомных реакторов" | Способ ионообменного выделения радионуклидов иттрия, редкоземельных и трансплутониевых элементов из растворов альфа-гидроксиизомасляной кислоты и ее солей |
| US20110277592A1 (en) * | 2008-11-06 | 2011-11-17 | The Curators Of The University Of Missouri | Separation method for carrier-free radiolanthanides |
| JP5376130B2 (ja) * | 2009-03-24 | 2013-12-25 | 独立行政法人日本原子力研究開発機構 | 抗体標識が可能な無担体１７７Ｌｕの分離精製法 |
-
2011
- 2011-07-15 DE DE102011051868A patent/DE102011051868B4/de active Active
-
2012
- 2012-04-04 HU HUE12163203A patent/HUE026163T2/en unknown
- 2012-04-04 PL PL12163203T patent/PL2546839T3/pl unknown
- 2012-04-04 EP EP12163203.8A patent/EP2546839B1/de active Active
- 2012-04-04 DK DK12163203.8T patent/DK2546839T3/en active
- 2012-04-04 SI SI201230436T patent/SI2546839T1/sl unknown
- 2012-04-04 ES ES12163203.8T patent/ES2558116T3/es active Active
- 2012-04-04 RS RS20150886A patent/RS54508B1/sr unknown
- 2012-04-04 PT PT121632038T patent/PT2546839E/pt unknown
- 2012-04-12 WO PCT/EP2012/056644 patent/WO2013010686A1/de not_active Ceased
- 2012-04-12 JP JP2014519460A patent/JP6219276B2/ja active Active
- 2012-04-12 CN CN201280035257.XA patent/CN103718250B/zh active Active
- 2012-04-12 RU RU2013155710/05A patent/RU2573475C2/ru active
- 2012-04-12 CA CA2839968A patent/CA2839968C/en active Active
- 2012-04-12 BR BR112014000857-4A patent/BR112014000857B1/pt active IP Right Grant
- 2012-04-12 US US14/232,205 patent/US9816156B2/en active Active
- 2012-04-12 KR KR1020147002410A patent/KR101931521B1/ko active Active
- 2012-04-24 AU AU2012202379A patent/AU2012202379B2/en active Active
- 2012-04-25 ZA ZA2012/03027A patent/ZA201203027B/en unknown
-
2016
- 2016-03-04 SM SM201600065T patent/SMT201600065B/xx unknown
-
2017
- 2017-04-28 JP JP2017090065A patent/JP6530007B2/ja active Active
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