JP2014520863A - Bruton型チロシンキナーゼの阻害剤 - Google Patents

Bruton型チロシンキナーゼの阻害剤 Download PDF

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JP2014520863A
JP2014520863A JP2014520391A JP2014520391A JP2014520863A JP 2014520863 A JP2014520863 A JP 2014520863A JP 2014520391 A JP2014520391 A JP 2014520391A JP 2014520391 A JP2014520391 A JP 2014520391A JP 2014520863 A JP2014520863 A JP 2014520863A
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JP2014520863A5 (enExample
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チェン,ウェイ
ロウリー,デイビッド,ジェイ.
モディー,タラク,ディー.
ワン,ロンチェン
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ファーマサイクリックス,インク.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2014520391A 2011-07-13 2012-07-13 Bruton型チロシンキナーゼの阻害剤 Pending JP2014520863A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161507482P 2011-07-13 2011-07-13
US61/507,482 2011-07-13
PCT/US2012/046779 WO2013010136A2 (en) 2011-07-13 2012-07-13 Inhibitors of bruton's tyrosine kinase

Publications (2)

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JP2014520863A true JP2014520863A (ja) 2014-08-25
JP2014520863A5 JP2014520863A5 (enExample) 2015-09-03

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US (2) US9138436B2 (enExample)
EP (1) EP2731612A4 (enExample)
JP (1) JP2014520863A (enExample)
KR (1) KR20140048968A (enExample)
CN (1) CN103857396A (enExample)
AU (1) AU2012283775A1 (enExample)
BR (1) BR112014000653A2 (enExample)
CA (1) CA2841080A1 (enExample)
EA (1) EA201490265A1 (enExample)
MX (1) MX2014000518A (enExample)
PH (1) PH12014500122A1 (enExample)
WO (1) WO2013010136A2 (enExample)
ZA (1) ZA201400012B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
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WO2016121953A1 (ja) * 2015-01-30 2016-08-04 大鵬薬品工業株式会社 免疫疾患の予防及び/又は治療剤
JP2018527384A (ja) * 2015-09-16 2018-09-20 ロクソ オンコロジー, インコーポレイテッドLoxo Oncology, Inc. がんの治療のためのbtk阻害剤としてのピラゾロピリミジン誘導体
JP2019507793A (ja) * 2016-03-11 2019-03-22 コーバス・ファーマシューティカルズ・インコーポレイテッド ブルトン型チロシンキナーゼを調節する化合物及び方法
JP2019535820A (ja) * 2016-11-15 2019-12-12 ハンヂョウ ハーツ ファーマシューティカル カンパニー リミテッド 選択性ブルトン型チロシンキナーゼ阻害剤及びその使用
JP2022523480A (ja) * 2019-01-18 2022-04-25 ミンフイ ファーマシューティカル (シャンハイ) リミテッド ブルトン型チロシンキナーゼ阻害剤としての環状分子
JP2023545414A (ja) * 2020-10-05 2023-10-30 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド Her2の強力かつ選択的な阻害剤

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JP2019535820A (ja) * 2016-11-15 2019-12-12 ハンヂョウ ハーツ ファーマシューティカル カンパニー リミテッド 選択性ブルトン型チロシンキナーゼ阻害剤及びその使用
JP2022523480A (ja) * 2019-01-18 2022-04-25 ミンフイ ファーマシューティカル (シャンハイ) リミテッド ブルトン型チロシンキナーゼ阻害剤としての環状分子
JP2023179562A (ja) * 2019-01-18 2023-12-19 ミンフイ ファーマシューティカル (シャンハイ) リミテッド ブルトン型チロシンキナーゼ阻害剤としての環状分子
JP7436994B2 (ja) 2019-01-18 2024-02-22 ミンフイ ファーマシューティカル (シャンハイ) リミテッド ブルトン型チロシンキナーゼ阻害剤としての環状分子
JP2023545414A (ja) * 2020-10-05 2023-10-30 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド Her2の強力かつ選択的な阻害剤
JP7849580B2 (ja) 2020-10-05 2026-04-22 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド Her2の強力かつ選択的な阻害剤

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US20130018032A1 (en) 2013-01-17
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US9862722B2 (en) 2018-01-09
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EA201490265A1 (ru) 2014-12-30
NZ619642A (en) 2016-04-29
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