JP2014520551A5 - - Google Patents

Download PDF

Info

Publication number
JP2014520551A5
JP2014520551A5 JP2014520269A JP2014520269A JP2014520551A5 JP 2014520551 A5 JP2014520551 A5 JP 2014520551A5 JP 2014520269 A JP2014520269 A JP 2014520269A JP 2014520269 A JP2014520269 A JP 2014520269A JP 2014520551 A5 JP2014520551 A5 JP 2014520551A5
Authority
JP
Japan
Prior art keywords
cells
nucleic acid
cell
culturing
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014520269A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014520551A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/046194 external-priority patent/WO2013009825A1/en
Publication of JP2014520551A publication Critical patent/JP2014520551A/ja
Publication of JP2014520551A5 publication Critical patent/JP2014520551A5/ja
Pending legal-status Critical Current

Links

JP2014520269A 2011-07-11 2012-07-11 細胞のリプログラミング方法およびゲノムの改変方法 Pending JP2014520551A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161506314P 2011-07-11 2011-07-11
US61/506,314 2011-07-11
PCT/US2012/046194 WO2013009825A1 (en) 2011-07-11 2012-07-11 Methods for cell reprogramming and genome engineering

Publications (2)

Publication Number Publication Date
JP2014520551A JP2014520551A (ja) 2014-08-25
JP2014520551A5 true JP2014520551A5 (https=) 2015-08-13

Family

ID=46516887

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014520269A Pending JP2014520551A (ja) 2011-07-11 2012-07-11 細胞のリプログラミング方法およびゲノムの改変方法

Country Status (5)

Country Link
US (2) US20130040302A1 (https=)
EP (1) EP2732029B1 (https=)
JP (1) JP2014520551A (https=)
CA (1) CA2841165A1 (https=)
WO (1) WO2013009825A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
KR102320571B1 (ko) 2011-12-05 2021-11-02 팩터 바이오사이언스 인크. 세포를 형질감염시키는 방법들 및 생성물들
WO2014071219A1 (en) 2012-11-01 2014-05-08 Factor Bioscience Inc. Methods and products for expressing proteins in cells
LT2966984T (lt) 2013-03-15 2022-05-25 Cibus Us Llc Tikslinė genų modifikacija, naudojant oligonukleotidų sukeltą genų taisymą
EP2792742A1 (en) 2013-04-17 2014-10-22 Universitätsklinikum Hamburg-Eppendorf (UKE) Gene-therapy vectors for treating cardiomyopathy
WO2015006725A2 (en) * 2013-07-12 2015-01-15 Cedars-Sinai Medical Center Generation of induced pluripotent stem cells from normal human mammary epithelial cells
KR101655383B1 (ko) 2013-07-27 2016-09-08 고려대학교 산학협력단 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물
ES2939542T3 (es) * 2014-01-31 2023-04-24 Factor Bioscience Inc Métodos y productos para la producción y la administración de ácido nucleico
CN105039399A (zh) * 2014-04-23 2015-11-11 复旦大学 多能干细胞-遗传性心肌病心肌细胞及其制备方法
AU2016211671B2 (en) 2015-01-26 2022-05-26 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
JP7199809B2 (ja) 2015-02-13 2023-01-06 ファクター バイオサイエンス インコーポレイテッド 核酸製品及びその投与方法
CA3003152A1 (en) 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
JP6928604B2 (ja) 2015-11-04 2021-09-01 フェイト セラピューティクス,インコーポレイテッド 万能性細胞のゲノム改変
EP3402496A4 (en) * 2016-01-12 2019-06-19 Lonza Walkersville, Inc. METHOD AND VECTORS FOR PRODUCING VECTOR-FREE INDUCED PLURIPOTENTER STEM CELLS
WO2017196175A1 (en) 2016-05-12 2017-11-16 Erasmus University Medical Center Rotterdam A method for culturing myogenic cells, cultures obtained therefrom, screening methods, and cell culture medium.
US10221395B2 (en) 2016-06-16 2019-03-05 Cedars-Sinai Medical Center Efficient method for reprogramming blood to induced pluripotent stem cells
US11572545B2 (en) 2016-06-16 2023-02-07 Cedars-Sinai Medical Center Efficient method for reprogramming blood to induced pluripotent stem cells
US10576167B2 (en) 2016-08-17 2020-03-03 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
CN110637090A (zh) * 2016-11-02 2019-12-31 D·基维利希 用于表达大型核酸转基因的质粒载体
WO2018195175A1 (en) * 2017-04-18 2018-10-25 FUJIFILM Cellular Dynamics, Inc. Antigen-specific immune effector cells
NL2019517B1 (en) 2017-09-08 2019-03-19 Univ Erasmus Med Ct Rotterdam New therapy for Pompe disease
KR20250051148A (ko) 2017-12-28 2025-04-16 더 제이. 데이비드 글래드스톤 인스티튜트, 어 테스터멘터리 트러스트 이스타빌리쉬드 언더 더 윌 오브 제이. 데이비드 글래드스톤 Crispr 활성화에 의한 유도 만능 세포의 생성
CN113881624A (zh) * 2018-01-29 2022-01-04 中国科学院动物研究所 一种细胞诱导的方法
CN110016483A (zh) * 2019-04-18 2019-07-16 安徽农业大学 一种研究卵母细胞体外成熟中卵丘细胞基因功能的方法
JP7699552B2 (ja) 2019-07-03 2025-06-27 ファクター バイオサイエンス インコーポレイテッド カチオン性脂質及びその使用
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
MY209860A (en) 2020-02-13 2025-08-07 Tenaya Therapeutics Inc Gene therapy vectors for treating heart disease
EP3922431A1 (en) 2020-06-08 2021-12-15 Erasmus University Medical Center Rotterdam Method of manufacturing microdevices for lab-on-chip applications
CN113201481B (zh) * 2021-04-19 2023-10-13 清华大学深圳国际研究生院 皮肤微球及其制备方法和应用
GB202115676D0 (en) * 2021-11-01 2021-12-15 Icahn School Med Mount Sinai Methods and compositions for bat ipsc preparation and use
WO2024091801A2 (en) * 2022-10-13 2024-05-02 President And Fellows Of Harvard College Methods and compositions for inducing cell differentiation

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1088100A (en) 1913-04-08 1914-02-24 Benjamin P Saunders Apparatus for unloading freight-cars.
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0273085A1 (en) 1986-12-29 1988-07-06 IntraCel Corporation A method for internalizing nucleic acids into eukaryotic cells
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5302523A (en) 1989-06-21 1994-04-12 Zeneca Limited Transformation of plant cells
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5550318A (en) 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5322783A (en) 1989-10-17 1994-06-21 Pioneer Hi-Bred International, Inc. Soybean transformation by microparticle bombardment
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
DK0641781T3 (da) 1991-09-06 2000-09-18 Yoshitomi Pharmaceutical 4-Amino(alkyl)cyclohexan-1-carboxamidforbindelser og anvendelse af disse
US5610042A (en) 1991-10-07 1997-03-11 Ciba-Geigy Corporation Methods for stable transformation of wheat
CA2122036C (en) 1991-10-23 2002-09-17 Gillian Anlezark Bacterial nitroreductase for the reduction of cb 1954 and analogues thereof to a cytotoxic form
US5702932A (en) 1992-07-20 1997-12-30 University Of Florida Microinjection methods to transform arthropods with exogenous DNA
WO1994002620A2 (en) 1992-07-27 1994-02-03 Pioneer Hi-Bred International, Inc. An improved method of agrobacterium-mediated transformation of cultured soybean cells
DE4228457A1 (de) 1992-08-27 1994-04-28 Beiersdorf Ag Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen
GB9222888D0 (en) 1992-10-30 1992-12-16 British Tech Group Tomography
US7083979B1 (en) 1994-03-25 2006-08-01 Indiana University Foundation Methods for enhanced retroviral-mediated gene transfer
US5686278A (en) 1994-03-25 1997-11-11 Indiana University Foundation Methods for enhanced retrovirus-mediated gene transfer
US6033907A (en) 1995-09-29 2000-03-07 Indiana University Foundation Enhanced virus-mediated DNA transfer
US5656610A (en) 1994-06-21 1997-08-12 University Of Southern California Producing a protein in a mammal by injection of a DNA-sequence into the tongue
FR2722208B1 (fr) 1994-07-05 1996-10-04 Inst Nat Sante Rech Med Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
JP4365456B2 (ja) 1995-09-29 2009-11-18 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション ウイルス及び細胞結合部位を持つ分子を用いたウイルス媒介性dna導入を増強する方法
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
US20030059913A1 (en) 1995-11-20 2003-03-27 Walter Weyler Novel Microorganisms with ability to degrade indole and novel enzymes therefrom
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US5981274A (en) 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
CA2277278A1 (en) 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
US5994624A (en) 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
GB0002261D0 (en) 2000-02-02 2000-03-22 Amersham Pharm Biotech Uk Ltd Fluorescent detection method & reagent
WO2001088100A1 (en) 2000-05-16 2001-11-22 Kyowa Hakko Kogyo Co., Ltd. Novel method of inducing the differentiation of embryonic stem cells into ectodermal cells and use thereof
JP5943533B2 (ja) 2000-05-17 2016-07-06 アステリアス バイオセラピューティクス インコーポレイテッド 神経前駆細胞の集団
JP2002184539A (ja) 2000-12-14 2002-06-28 Auto Network Gijutsu Kenkyusho:Kk コネクタ
US20030125344A1 (en) 2001-03-23 2003-07-03 Bayer Corporation Rho-kinase inhibitors
MXPA03008659A (es) 2001-03-23 2005-04-08 Bayer Ag Inhibidores de rho-cinasa.
US20030211603A1 (en) 2001-08-14 2003-11-13 Earp David J. Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
JP2003097552A (ja) 2001-09-21 2003-04-03 Nsk Ltd 摩擦付加装置および直動案内装置
US20030062225A1 (en) 2001-10-03 2003-04-03 Stucky Paul A. Elevator load bearing assembly having a detectable element that is indicative of local strain
DE60320933D1 (de) 2002-01-10 2008-06-26 Bayer Healthcare Ag Rho-kinase inhibitoren
MXPA04007196A (es) 2002-01-23 2005-06-08 Bayer Pharmaceuticals Corp Inhibidores de rho-quinasa.
JP4469179B2 (ja) 2002-01-23 2010-05-26 バイエル ファーマセチカル コーポレーション Rhoキナーゼ阻害剤としてのピリミジン誘導体
DE10224242A1 (de) 2002-05-29 2003-12-11 Max Delbrueck Centrum Frog Prince, ein Transposonvektor für den Gentransfer bei Wirbeltieren
US20040039796A1 (en) 2002-08-08 2004-02-26 Virtual Radio, Inc. Personalized cyber disk jockey and Internet radio advertising
JP2004295625A (ja) 2003-03-27 2004-10-21 Fujitsu Ltd エリア情報提供システム、エリア情報提供プログラム
US20050123902A1 (en) 2003-05-21 2005-06-09 President And Fellows Of Harvard College Human papillomavirus inhibitors
WO2005080554A1 (ja) 2004-02-23 2005-09-01 Kyoto University 胚性幹細胞の分化調節方法
AU2005282414C1 (en) 2004-09-08 2011-04-07 Wisconsin Alumni Research Foundation Culturing human embryonic stem cells
US20070116680A1 (en) 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
EP2457995A1 (en) 2006-03-30 2012-05-30 The University Court of The University of Edinburgh Culture medium containing kinase inhibitors, and uses thereof
CN101595107A (zh) 2006-06-30 2009-12-02 先灵公司 能提高p53活性的有取代哌啶及其用途
BRPI0714409A2 (pt) 2006-07-14 2013-03-12 Novartis Ag derivados de pirimidina como inibidores de alk-5
WO2008089351A1 (en) 2007-01-17 2008-07-24 Wisconsin Alumni Research Foundation Improved culture of stem cells
CN103627671A (zh) 2007-01-30 2014-03-12 佐治亚大学研究基金会 产生中内胚层细胞及多能游走细胞的方法与细胞群及用途
US20110061118A1 (en) * 2008-03-17 2011-03-10 Helmholtz Zentrum Munchen Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination
EP3279314A1 (en) * 2008-06-04 2018-02-07 Cellular Dynamics International, Inc. Methods for the production of ips cells using non-viral approach
JP2011525794A (ja) * 2008-06-26 2011-09-29 国立大学法人大阪大学 iPS細胞の製造方法および製造キット
WO2010042490A1 (en) * 2008-10-06 2010-04-15 Boston Medical Center Corporation A single lentiviral vector system for induced pluripotent (ips) stem cells derivation
CA2741090C (en) * 2008-10-24 2018-10-16 Wisconsin Alumni Research Foundation Pluripotent stem cells obtained by non-viral reprogramming
ES2539487T3 (es) 2009-11-04 2015-07-01 Cellular Dynamics International, Inc. Reprogramación episómica con compuestos químicos
WO2012018933A2 (en) * 2010-08-04 2012-02-09 Cellular Dynamics International, Inc. Reprogramming immortalized b cells

Similar Documents

Publication Publication Date Title
JP2014520551A5 (https=)
Von Niessen et al. Improving mRNA-based therapeutic gene delivery by expression-augmenting 3′ UTRs identified by cellular library screening
Li et al. Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells
Wakao et al. Morphologic and gene expression criteria for identifying human induced pluripotent stem cells
Manzini et al. A comparative view on easy to deploy non-integrating methods for patient-specific iPSC production
AU2019247100B2 (en) Reprogramming vectors
CN103003416A (zh) 从小体积的外周血产生诱导性多潜能干细胞
CN103562376A (zh) 复壮细胞的方法
AU2008201280A1 (en) Genes with ES cell-specific expression
CN105051188A (zh) 新颖方法
JP2016520288A (ja) 効率的な人工多能性幹細胞の樹立方法
JP6854461B2 (ja) ウイルスベクター、iPS細胞の作製方法およびコンストラクト
CN104884612A (zh) Mait样细胞及其制作方法
Hiramoto et al. Non-transmissible MV vector with segmented RNA genome establishes different types of iPSCs from hematopoietic cells
Di Stefano et al. A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells
US12571042B2 (en) Markers specific for pluripotent stem cells, and methods of using the same
Ishiguro et al. A multi-kingdom genetic barcoding system for precise target clone isolation
Busley et al. Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p. G23V
CN110267981B (zh) 用于从单t细胞克隆功能性t细胞受体的方法和材料
JP2023516484A (ja) 肝細胞作製方法
Sato et al. The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation
US20250027155A1 (en) Markers specific for pluripotent stem cells, and methods of using the same
Chudzik Generation of induced pluripotent stem cells from fibroblast cell lines and gene editing in pluripotent stem cell
Daheron et al. iPSC culture: best practices from sample procurement to reprogramming and differentiation
Diana et al. Tracking HIV-1 DNA fate from Cell Culture to Humanized mice Tissues