JP2014516968A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014516968A5 JP2014516968A5 JP2014511589A JP2014511589A JP2014516968A5 JP 2014516968 A5 JP2014516968 A5 JP 2014516968A5 JP 2014511589 A JP2014511589 A JP 2014511589A JP 2014511589 A JP2014511589 A JP 2014511589A JP 2014516968 A5 JP2014516968 A5 JP 2014516968A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- salt
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(*)NP(COCc1ccccc1)(Oc1ccccc1)=O Chemical compound CC(*)NP(COCc1ccccc1)(Oc1ccccc1)=O 0.000 description 4
- RRUSGPITJKSLPR-UHFFFAOYSA-N CC(NC(COC)(C[O]=C)O)[Mn] Chemical compound CC(NC(COC)(C[O]=C)O)[Mn] RRUSGPITJKSLPR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488133P | 2011-05-19 | 2011-05-19 | |
| US61/488,133 | 2011-05-19 | ||
| PCT/US2012/038615 WO2012159047A1 (en) | 2011-05-19 | 2012-05-18 | Processes and intermediates for preparing anti-hiv agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016005955A Division JP6282295B2 (ja) | 2011-05-19 | 2016-01-15 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516968A JP2014516968A (ja) | 2014-07-17 |
| JP2014516968A5 true JP2014516968A5 (enExample) | 2015-07-02 |
| JP5951757B2 JP5951757B2 (ja) | 2016-07-13 |
Family
ID=46208163
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511589A Active JP5951757B2 (ja) | 2011-05-19 | 2012-05-18 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2016005955A Active JP6282295B2 (ja) | 2011-05-19 | 2016-01-15 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2017019959A Active JP6621772B2 (ja) | 2011-05-19 | 2017-02-06 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2019017324A Pending JP2019089808A (ja) | 2011-05-19 | 2019-02-01 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016005955A Active JP6282295B2 (ja) | 2011-05-19 | 2016-01-15 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2017019959A Active JP6621772B2 (ja) | 2011-05-19 | 2017-02-06 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2019017324A Pending JP2019089808A (ja) | 2011-05-19 | 2019-02-01 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8987437B2 (enExample) |
| EP (3) | EP2710019B1 (enExample) |
| JP (4) | JP5951757B2 (enExample) |
| AR (1) | AR086492A1 (enExample) |
| AU (4) | AU2012255029B2 (enExample) |
| CA (1) | CA2835932C (enExample) |
| ES (2) | ES2700470T3 (enExample) |
| PT (2) | PT2710019T (enExample) |
| TW (1) | TWI635093B (enExample) |
| WO (1) | WO2012159047A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987437B2 (en) | 2011-05-19 | 2015-03-24 | Gilead Sciences, Inc. | Processes and intermediates for preparing anti-HIV Agents |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| US20180085387A1 (en) | 2016-09-27 | 2018-03-29 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
| EP3661937B1 (en) | 2017-08-01 | 2021-07-28 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) for treating viral infections |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| CN114409706B (zh) * | 2019-07-01 | 2023-11-28 | 上海医药工业研究院 | 一种苯基氢膦酸酯及其中间体的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US599431A (en) | 1898-02-22 | Clothes-wringer | ||
| GB835785A (en) * | 1956-04-30 | 1960-05-25 | Victor Chemical Works | Method of making diaryl phosphites |
| MX3898E (es) * | 1975-12-29 | 1981-09-10 | Monsanto Co | Procedimiento mejorado para la preparacion de triesteres de n-fosfonometilglicina |
| US4198355A (en) * | 1977-03-28 | 1980-04-15 | Mobil Oil Corporation | Preparation of tertiary alkylphosphorodichloridite derivatives |
| US5459256A (en) * | 1987-04-17 | 1995-10-17 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Lipophilic, aminohydrolase-activated prodrugs |
| HU906976D0 (en) | 1989-11-13 | 1991-05-28 | Bristol Myers Squibb Co | Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| OA12393A (en) | 2000-07-21 | 2006-04-18 | Gilead Sciences Inc | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same. |
| WO2003090691A2 (en) * | 2002-04-26 | 2003-11-06 | Gilead Sciences, Inc. | Method and compositions for identifying anti-hiv therapeutic compounds |
| JP2010535701A (ja) * | 2003-04-25 | 2010-11-25 | ギリアード サイエンシーズ， インコーポレイテッド | 抗癌ホスホネートアナログ |
| CA2523083C (en) * | 2003-04-25 | 2014-07-08 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| PT1778702E (pt) | 2004-07-16 | 2011-10-18 | Gilead Sciences Inc | Compostos antivirais |
| PL216369B1 (pl) | 2004-07-27 | 2014-03-31 | Gilead Sciences | Pochodne fosfonianowe, kompozycje farmaceutyczne zawierające te pochodne oraz zastosowanie tych pochodnych do wytwarzania leku do hamowania wirusa HIV |
| JP2009502964A (ja) * | 2005-07-27 | 2009-01-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを阻害するための抗ウイルス性ホスホン酸結合体 |
| PL387008A1 (pl) * | 2006-03-17 | 2009-05-11 | Invista Technologies S.A.R.L. | Sposób oczyszczania triorganofosforynów przez obróbkę dodatkiem zasadowym |
| WO2008100447A2 (en) | 2007-02-09 | 2008-08-21 | Gilead Sciences, Inc. | Nucleoside analogs for antiviral treatment |
| JP5620376B2 (ja) | 2008-07-08 | 2014-11-05 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ阻害剤化合物の塩 |
| US9790252B2 (en) * | 2009-07-01 | 2017-10-17 | Cornell University | 2-fluorinated riboses and arabinoses and methods of use and synthesis |
| US8987437B2 (en) | 2011-05-19 | 2015-03-24 | Gilead Sciences, Inc. | Processes and intermediates for preparing anti-HIV Agents |
-
2012
- 2012-05-18 US US13/475,569 patent/US8987437B2/en active Active
- 2012-05-18 PT PT127255701T patent/PT2710019T/pt unknown
- 2012-05-18 PT PT16204289T patent/PT3199537T/pt unknown
- 2012-05-18 EP EP12725570.1A patent/EP2710019B1/en active Active
- 2012-05-18 CA CA2835932A patent/CA2835932C/en active Active
- 2012-05-18 ES ES16204289T patent/ES2700470T3/es active Active
- 2012-05-18 ES ES12725570.1T patent/ES2629913T3/es active Active
- 2012-05-18 AU AU2012255029A patent/AU2012255029B2/en active Active
- 2012-05-18 TW TW101117811A patent/TWI635093B/zh active
- 2012-05-18 EP EP18200819.3A patent/EP3450438A1/en not_active Withdrawn
- 2012-05-18 JP JP2014511589A patent/JP5951757B2/ja active Active
- 2012-05-18 WO PCT/US2012/038615 patent/WO2012159047A1/en not_active Ceased
- 2012-05-18 EP EP16204289.9A patent/EP3199537B1/en active Active
- 2012-05-18 AR ARP120101777A patent/AR086492A1/es unknown
-
2015
- 2015-02-05 US US14/615,357 patent/US9296779B2/en active Active
-
2016
- 2016-01-15 JP JP2016005955A patent/JP6282295B2/ja active Active
- 2016-02-17 US US15/046,399 patent/US9783567B2/en active Active
- 2016-07-26 AU AU2016208292A patent/AU2016208292B2/en active Active
-
2017
- 2017-02-06 JP JP2017019959A patent/JP6621772B2/ja active Active
- 2017-09-06 US US15/697,136 patent/US10196419B2/en active Active
-
2018
- 2018-02-01 AU AU2018200776A patent/AU2018200776B2/en active Active
- 2018-12-20 US US16/226,811 patent/US20190359644A1/en not_active Abandoned
-
2019
- 2019-02-01 JP JP2019017324A patent/JP2019089808A/ja active Pending
- 2019-09-09 AU AU2019226278A patent/AU2019226278A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014516968A5 (enExample) | ||
| JP2018529687A5 (enExample) | ||
| KR102479201B1 (ko) | (1r,3r)- 및 (1s,3s)-2,2-디할로-3-(치환된 페닐)시클로프로판카르복실산의 제조 방법 | |
| KR101532570B1 (ko) | 벤즈아미드 화합물의 합성에 유용한 화합물 | |
| JP2021506774A (ja) | 抗蠕虫性４−アミノ−キノリン−３−カルボキサミド誘導体を調製する方法 | |
| KR20130142477A (ko) | 키랄 나이트로사이클로프로판 유도체의 제조방법 | |
| PE20231843A1 (es) | Reactivos quirales para la preparacion de oligomeros homogeneos | |
| CN107074739A (zh) | 2‑甲氧基甲基‑对苯二胺的叠缩合成 | |
| TWI455933B (zh) | 貝他斯汀或其苯磺酸鹽之製法及其使用之中間體 | |
| CN104086509A (zh) | 甲基丙烯酸缩水甘油酯的合成方法 | |
| RU2018100967A (ru) | Способ получения азотсодержащего гетероциклического соединения и его промежуточного соединения | |
| JP2015500875A (ja) | マグノロール類似体を製造するための方法 | |
| TW201127804A (en) | Novel alkoxy enones and enamino ketones and a process for preparation thereof | |
| JP2018505179A5 (enExample) | ||
| JP2016537447A5 (enExample) | ||
| AR054849A1 (es) | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas | |
| EP2522648B1 (en) | Process for producing difluorocyclopropane compound | |
| JP2017095455A (ja) | Ｎ，ｎ’−ビス（２−シアノエチル）−１，２−エチレンジアミンの調製方法 | |
| JP2015526507A (ja) | フルボキサミン遊離塩基の精製方法およびそれを用いた高純度フルボキサミンマレイン酸塩の製造方法 | |
| EP2888250B1 (en) | Process for the synthesis of substituted gamma lactams | |
| KR101462468B1 (ko) | 염산 에페리손의 제조방법 | |
| RU2016113336A (ru) | Производные оксимов 4-бензоилпиридина, обладающие противосудорожной активностью, как средства лечения эпилепсии и пароксизмальных состояний | |
| JP4827531B2 (ja) | エナンチオ選択的なエナミドのイミンへの求核付加反応方法とα−アミノ−γ−ケト酸エステルの合成方法 | |
| JP6809485B2 (ja) | 酸ハライド溶液の製造方法、及びモノエステル化合物の製造方法 | |
| KR101468209B1 (ko) | 4차 탄소를 갖는 아민 유도체 및 이의 제조방법 |