JP2014515038A5 - - Google Patents
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- Publication number
- JP2014515038A5 JP2014515038A5 JP2014510901A JP2014510901A JP2014515038A5 JP 2014515038 A5 JP2014515038 A5 JP 2014515038A5 JP 2014510901 A JP2014510901 A JP 2014510901A JP 2014510901 A JP2014510901 A JP 2014510901A JP 2014515038 A5 JP2014515038 A5 JP 2014515038A5
- Authority
- JP
- Japan
- Prior art keywords
- testosterone
- intranasal
- gel
- male
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 20
- 229960003604 testosterone Drugs 0.000 claims 10
- 206010002261 Androgen deficiency Diseases 0.000 claims 2
- 230000036765 blood level Effects 0.000 claims 1
- 210000003928 nasal cavity Anatomy 0.000 claims 1
- 230000009469 supplementation Effects 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 239000004034 viscosity adjusting agent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486324P | 2011-05-15 | 2011-05-15 | |
| US61/486,324 | 2011-05-15 | ||
| US201161486634P | 2011-05-16 | 2011-05-16 | |
| US61/486,634 | 2011-05-16 | ||
| PCT/IB2012/001127 WO2012156822A1 (en) | 2011-05-15 | 2012-05-15 | Controlled release nasal testosterone gels, methods and pre-filled multi-dose applicator systems for pernasal administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017056679A Division JP6594924B2 (ja) | 2011-05-15 | 2017-03-22 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515038A JP2014515038A (ja) | 2014-06-26 |
| JP2014515038A5 true JP2014515038A5 (enExample) | 2015-07-09 |
| JP6152092B2 JP6152092B2 (ja) | 2017-06-28 |
Family
ID=46579248
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510901A Expired - Fee Related JP6152092B2 (ja) | 2011-05-15 | 2012-05-15 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2014510900A Pending JP2014513716A (ja) | 2011-05-15 | 2012-05-15 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2017056679A Expired - Fee Related JP6594924B2 (ja) | 2011-05-15 | 2017-03-22 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2018158566A Pending JP2018199701A (ja) | 2011-05-15 | 2018-08-27 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2019173990A Active JP7017254B2 (ja) | 2011-05-15 | 2019-09-25 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2020012807A Pending JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2020157216A Pending JP2021001206A (ja) | 2011-05-15 | 2020-09-18 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022034334A Pending JP2022078222A (ja) | 2011-05-15 | 2022-03-07 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022076671A Pending JP2022105175A (ja) | 2011-05-15 | 2022-05-06 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510900A Pending JP2014513716A (ja) | 2011-05-15 | 2012-05-15 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2017056679A Expired - Fee Related JP6594924B2 (ja) | 2011-05-15 | 2017-03-22 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2018158566A Pending JP2018199701A (ja) | 2011-05-15 | 2018-08-27 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2019173990A Active JP7017254B2 (ja) | 2011-05-15 | 2019-09-25 | 経鼻投与のための徐放テストステロン鼻腔内ゲル、方法および複数回用量プレフィルアプリケーターシステム |
| JP2020012807A Pending JP2020079257A (ja) | 2011-05-15 | 2020-01-29 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2020157216A Pending JP2021001206A (ja) | 2011-05-15 | 2020-09-18 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022034334A Pending JP2022078222A (ja) | 2011-05-15 | 2022-03-07 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
| JP2022076671A Pending JP2022105175A (ja) | 2011-05-15 | 2022-05-06 | 鼻腔内テストステロン生体付着性ゲル製剤および男性の性腺機能低下症の治療のためのその使用 |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP3977982A1 (enExample) |
| JP (9) | JP6152092B2 (enExample) |
| KR (10) | KR20230041081A (enExample) |
| CN (4) | CN103813784A (enExample) |
| AR (2) | AR086409A1 (enExample) |
| AU (11) | AU2012257492A1 (enExample) |
| BR (2) | BR112013029332A2 (enExample) |
| CA (3) | CA3034552C (enExample) |
| DK (1) | DK2714006T3 (enExample) |
| EA (1) | EA201391701A1 (enExample) |
| ES (1) | ES2859784T3 (enExample) |
| IL (2) | IL229401A0 (enExample) |
| MX (4) | MX2013013369A (enExample) |
| PL (1) | PL2714006T3 (enExample) |
| WO (2) | WO2012156822A1 (enExample) |
| ZA (2) | ZA201309265B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| MX2013013369A (es) * | 2011-05-15 | 2014-10-17 | Trimel Biopharma Srl | Formulaciones de gel bioadhesivo de testosterona intranasal y uso del mismo para tratar hipogonadismo masculino. |
| US8971800B2 (en) * | 2011-05-31 | 2015-03-03 | Qualcomm Incorporated | Methods and apparatus for improving NFC activation and data exchange reporting mechanisms |
| EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2014076569A2 (en) * | 2012-11-14 | 2014-05-22 | Trimel Biopharma Srl | Controlled release topical testosterone formulations and methods |
| WO2014093818A2 (en) * | 2012-12-14 | 2014-06-19 | Bioject, Inc. | Use of a novel subcutaneous needle-free technique to deliver testosterone in hypogonadal men |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| US11160751B2 (en) * | 2013-10-07 | 2021-11-02 | Antares Pharma, Inc. | Hematocrit modulation through needle assisted jet injection of testosterone |
| EP4062918A1 (en) | 2014-02-19 | 2022-09-28 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| KR20170040209A (ko) | 2014-07-29 | 2017-04-12 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 경피 크림 |
| TW201636045A (zh) * | 2015-01-28 | 2016-10-16 | 波美西恩製藥有限責任公司 | 組成物、促進或增強受試者之局部毛髮飽滿度及厚度或毛髮生長之方法、包括該組成物之套組及裝置 |
| US20160374800A1 (en) * | 2015-06-29 | 2016-12-29 | Changcheng You | Implantable scaffolds for treatment of sinusitis |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| BR102015020878B1 (pt) * | 2015-08-28 | 2019-08-27 | F B M Ind Farmaceutica Ltda | formulação farmacêutica nasal de testosterona e “kit” em forma de cartela de dispositivos nasais unitários para aplicação de monodose de testosterona. |
| IL300437B1 (en) * | 2016-01-07 | 2026-06-01 | Viramal Ltd | Gel formulations for transdermal drug delivery to maximize drug concentrations in the stratum corneum and serum and methods of using them |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| BR112018071699A2 (pt) | 2016-04-25 | 2019-02-19 | Andrew Koska Marc | sistema de liberação médica |
| WO2017208072A2 (en) * | 2016-06-02 | 2017-12-07 | Acerus Pharmaceutical Corporation | Nasal cannabidiol compositions |
| US11903951B2 (en) * | 2016-06-03 | 2024-02-20 | M et P Pharma AG | Nasal pharmaceutical compositions with a porous excipient |
| HUE063346T2 (hu) * | 2017-01-20 | 2024-01-28 | M et P Pharma AG | Nazális gyógyszerészeti készítmények légszennyezõ anyagoknak való kitettség kockázatainak csökkentésére |
| CN110999431B (zh) * | 2017-06-17 | 2022-04-05 | Lg电子株式会社 | 用于在无线通信系统中注册终端的方法及其设备 |
| WO2019099954A1 (en) | 2017-11-17 | 2019-05-23 | Koska Family Limited | Systems and methods for fluid delivery manifolds |
| MX2020005437A (es) * | 2017-11-27 | 2020-08-27 | Aska Pharm Co Ltd | Preparacion en polvo para administracion nasal. |
| US20190240237A1 (en) * | 2018-02-02 | 2019-08-08 | Aytu Bioscience, Inc. | Methods of testosterone therapy |
| WO2019175290A1 (en) | 2018-03-13 | 2019-09-19 | Beckley Canopy Therapeutics Limited | Cannabis or cannabis derived compositions for promoting cessation of chemical dependence |
| US12544511B2 (en) | 2018-06-20 | 2026-02-10 | Koska Family Limited | Systems and methods for pre-filled dual-chamber medical agent delivery |
| CN108771622B (zh) * | 2018-07-11 | 2022-01-07 | 尹振图 | 一种自闭式针形滴嘴及眼药水瓶 |
| AU2019365255B2 (en) | 2018-10-26 | 2025-06-12 | Viramal Limited | Mucoadhesive gel composition |
| EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
| US20200170962A1 (en) | 2018-11-30 | 2020-06-04 | F. Markus Leweke | Nasal cannabidiol compositions |
| CN113365635A (zh) * | 2018-12-14 | 2021-09-07 | 阿克罗斯生物制药公司 | 睾酮的活性酯衍生物、组合物和其用途 |
| USD1052082S1 (en) | 2020-06-01 | 2024-11-19 | Koska Family Limited | Sealed fluid container |
| CN112121049B (zh) * | 2020-08-28 | 2022-02-01 | 嘉兴市第一医院 | 顺式阿曲库铵在制备治疗男性性腺功能减退症的药物中的应用 |
| MX2023005822A (es) * | 2020-11-19 | 2023-05-31 | Acousia Therapeutics Gmbh | Composicion de gel no acuoso. |
| EP4429737A1 (en) | 2021-11-11 | 2024-09-18 | Koska Family Limited | Bfs injection and connection assemblies |
| GB202307501D0 (en) * | 2023-05-19 | 2023-07-05 | Lawley Pharmaceuticals Pty Ltd | Process for preparing dispensable testosterone cream |
| CN116983253A (zh) * | 2023-07-31 | 2023-11-03 | 湖南省儿童医院(湖南省红十字会医院) | 一种载难溶性药物的温敏凝胶及其制备方法与应用 |
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| EP1896038B1 (en) * | 2005-06-03 | 2016-11-09 | Acrux DDS Pty Ltd | Method and composition for testosterone transdermal delivery |
| EP1790343A1 (en) * | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| CN101099742A (zh) * | 2006-07-06 | 2008-01-09 | 上海富海科申药业有限公司 | 能够减少皮肤刺激的睾酮凝胶制剂 |
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| DK2060300T3 (da) * | 2007-11-13 | 2015-06-22 | Curadis Gmbh | C-19-steroider til terapeutiske anvendelser |
| GB0807605D0 (en) * | 2008-04-28 | 2008-06-04 | Diurnal Ltd | Lipid composition |
| MX2013013369A (es) * | 2011-05-15 | 2014-10-17 | Trimel Biopharma Srl | Formulaciones de gel bioadhesivo de testosterona intranasal y uso del mismo para tratar hipogonadismo masculino. |
-
2012
- 2012-05-15 MX MX2013013369A patent/MX2013013369A/es unknown
- 2012-05-15 MX MX2020008599A patent/MX395212B/es unknown
- 2012-05-15 CA CA3034552A patent/CA3034552C/en active Active
- 2012-05-15 CA CA2836405A patent/CA2836405C/en active Active
- 2012-05-15 AU AU2012257492A patent/AU2012257492A1/en not_active Abandoned
- 2012-05-15 JP JP2014510901A patent/JP6152092B2/ja not_active Expired - Fee Related
- 2012-05-15 KR KR1020237008221A patent/KR20230041081A/ko not_active Ceased
- 2012-05-15 ES ES12748245T patent/ES2859784T3/es active Active
- 2012-05-15 EA EA201391701A patent/EA201391701A1/ru unknown
- 2012-05-15 BR BR112013029332-2A patent/BR112013029332A2/pt not_active Application Discontinuation
- 2012-05-15 JP JP2014510900A patent/JP2014513716A/ja active Pending
- 2012-05-15 MX MX2013013388A patent/MX363561B/es unknown
- 2012-05-15 CN CN201280035162.8A patent/CN103813784A/zh active Pending
- 2012-05-15 KR KR1020137033181A patent/KR20140045400A/ko not_active Ceased
- 2012-05-15 PL PL12748245T patent/PL2714006T3/pl unknown
- 2012-05-15 CN CN201280035150.5A patent/CN103796636B/zh not_active Expired - Fee Related
- 2012-05-15 EP EP21191386.8A patent/EP3977982A1/en not_active Withdrawn
- 2012-05-15 AU AU2012257490A patent/AU2012257490A1/en not_active Abandoned
- 2012-05-15 EP EP12738595.3A patent/EP2709588B1/en active Active
- 2012-05-15 WO PCT/IB2012/001127 patent/WO2012156822A1/en not_active Ceased
- 2012-05-15 KR KR1020197029484A patent/KR20190117803A/ko not_active Ceased
- 2012-05-15 EP EP12748245.3A patent/EP2714006B1/en active Active
- 2012-05-15 KR KR1020187038088A patent/KR102088038B1/ko active Active
- 2012-05-15 KR KR1020207028301A patent/KR20200118228A/ko not_active Ceased
- 2012-05-15 KR KR1020247037387A patent/KR20240162608A/ko active Pending
- 2012-05-15 WO PCT/IB2012/001112 patent/WO2012156820A1/en not_active Ceased
- 2012-05-15 CN CN201910982324.2A patent/CN110613679A/zh active Pending
- 2012-05-15 KR KR1020217007047A patent/KR102568894B1/ko active Active
- 2012-05-15 CA CA2836398A patent/CA2836398C/en active Active
- 2012-05-15 KR KR1020137033180A patent/KR20140033408A/ko not_active Ceased
- 2012-05-15 MX MX2019003340A patent/MX374398B/es active IP Right Grant
- 2012-05-15 DK DK12748245.3T patent/DK2714006T3/da active
- 2012-05-15 BR BR112013029336-5A patent/BR112013029336B1/pt active IP Right Grant
- 2012-05-15 KR KR1020217036024A patent/KR20210135003A/ko not_active Ceased
- 2012-05-15 KR KR1020207006630A patent/KR20200028503A/ko not_active Ceased
- 2012-05-15 CN CN201811198846.5A patent/CN109481394B/zh not_active Expired - Fee Related
- 2012-05-16 AR ARP120101720A patent/AR086409A1/es not_active Application Discontinuation
- 2012-05-16 AR ARP120101721A patent/AR089553A1/es not_active Application Discontinuation
-
2013
- 2013-11-11 IL IL229401A patent/IL229401A0/en unknown
- 2013-11-11 IL IL229400A patent/IL229400A0/en unknown
- 2013-12-09 ZA ZA2013/09265A patent/ZA201309265B/en unknown
- 2013-12-09 ZA ZA2013/09264A patent/ZA201309264B/en unknown
-
2017
- 2017-03-22 JP JP2017056679A patent/JP6594924B2/ja not_active Expired - Fee Related
- 2017-05-24 AU AU2017203470A patent/AU2017203470A1/en not_active Abandoned
- 2017-06-20 AU AU2017204182A patent/AU2017204182A1/en not_active Abandoned
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2018
- 2018-08-27 JP JP2018158566A patent/JP2018199701A/ja active Pending
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2019
- 2019-03-08 AU AU2019201618A patent/AU2019201618A1/en not_active Abandoned
- 2019-04-30 AU AU2019203067A patent/AU2019203067A1/en not_active Abandoned
- 2019-05-15 AU AU2019203400A patent/AU2019203400A1/en not_active Abandoned
- 2019-09-25 JP JP2019173990A patent/JP7017254B2/ja active Active
-
2020
- 2020-01-29 JP JP2020012807A patent/JP2020079257A/ja active Pending
- 2020-07-29 AU AU2020210227A patent/AU2020210227A1/en not_active Abandoned
- 2020-09-18 JP JP2020157216A patent/JP2021001206A/ja active Pending
- 2020-11-09 AU AU2020267162A patent/AU2020267162B2/en not_active Ceased
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2022
- 2022-03-07 JP JP2022034334A patent/JP2022078222A/ja active Pending
- 2022-04-12 AU AU2022202402A patent/AU2022202402A1/en not_active Abandoned
- 2022-05-06 JP JP2022076671A patent/JP2022105175A/ja active Pending
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2024
- 2024-08-23 AU AU2024216312A patent/AU2024216312A1/en active Pending
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