JP2014513916A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014513916A5 JP2014513916A5 JP2013551435A JP2013551435A JP2014513916A5 JP 2014513916 A5 JP2014513916 A5 JP 2014513916A5 JP 2013551435 A JP2013551435 A JP 2013551435A JP 2013551435 A JP2013551435 A JP 2013551435A JP 2014513916 A5 JP2014513916 A5 JP 2014513916A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- aps
- esb
- items
- uba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437854P | 2011-01-31 | 2011-01-31 | |
| US61/437,854 | 2011-01-31 | ||
| US201161444067P | 2011-02-17 | 2011-02-17 | |
| US61/444,067 | 2011-02-17 | ||
| PCT/US2012/023411 WO2012106385A2 (en) | 2011-01-31 | 2012-01-31 | Methods of identifying multiple epitopes in cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513916A JP2014513916A (ja) | 2014-06-19 |
| JP2014513916A5 true JP2014513916A5 (https=) | 2015-03-19 |
| JP6069224B2 JP6069224B2 (ja) | 2017-02-01 |
Family
ID=46603278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551435A Active JP6069224B2 (ja) | 2011-01-31 | 2012-01-31 | 細胞において複数のエピトープを同定する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (23) | US10144950B2 (https=) |
| EP (1) | EP2670863B1 (https=) |
| JP (1) | JP6069224B2 (https=) |
| CN (1) | CN103703143B (https=) |
| ES (1) | ES2687761T3 (https=) |
| WO (1) | WO2012106385A2 (https=) |
Families Citing this family (152)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009536313A (ja) | 2006-01-11 | 2009-10-08 | レインダンス テクノロジーズ， インコーポレイテッド | ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法 |
| ATE540750T1 (de) | 2006-05-11 | 2012-01-15 | Raindance Technologies Inc | Mikrofluidische vorrichtung und verfahren |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP2315629B1 (en) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| EP3415235B1 (en) | 2009-03-23 | 2025-11-12 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| CA2789425C (en) | 2010-02-12 | 2020-04-28 | Raindance Technologies, Inc. | Digital analyte analysis with polymerase error correction |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| JP6069224B2 (ja) | 2011-01-31 | 2017-02-01 | アプライズ バイオ， インコーポレイテッド | 細胞において複数のエピトープを同定する方法 |
| US10995362B2 (en) | 2011-01-31 | 2021-05-04 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US10982271B2 (en) | 2011-01-31 | 2021-04-20 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US11560585B2 (en) | 2011-01-31 | 2023-01-24 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US9347059B2 (en) * | 2011-04-25 | 2016-05-24 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
| EP3709018A1 (en) | 2011-06-02 | 2020-09-16 | Bio-Rad Laboratories, Inc. | Microfluidic apparatus for identifying components of a chemical reaction |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US10941396B2 (en) | 2012-02-27 | 2021-03-09 | Becton, Dickinson And Company | Compositions and kits for molecular counting |
| EP2882868B1 (en) * | 2012-08-08 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Increasing dynamic range for identifying multiple epitopes in cells |
| AU2013302867A1 (en) | 2012-08-13 | 2015-02-26 | The Regents Of The University Of California | Methods and systems for detecting biological components |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CA3216609C (en) | 2012-08-14 | 2024-05-14 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2014093676A1 (en) | 2012-12-14 | 2014-06-19 | 10X Technologies, Inc. | Methods and systems for processing polynucleotides |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| AU2014214682B2 (en) | 2013-02-08 | 2018-07-26 | 10X Genomics, Inc. | Polynucleotide barcode generation |
| CN105189749B (zh) * | 2013-03-15 | 2020-08-11 | 血统生物科学公司 | 用于标记和分析样品的方法和组合物 |
| BR112015032512A8 (pt) * | 2013-06-27 | 2020-01-07 | 10X Genomics Inc | método de implementação de código de barras de materiais de amostra |
| ES2711168T3 (es) | 2013-08-28 | 2019-04-30 | Becton Dickinson Co | Análisis masivo en paralelo de células individuales |
| CN105745334B (zh) * | 2013-09-30 | 2019-12-10 | 吴迪 | 通过使用邻近条形编码分析分子复合物的概况的方法 |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015157567A1 (en) | 2014-04-10 | 2015-10-15 | 10X Genomics, Inc. | Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same |
| US20150298091A1 (en) | 2014-04-21 | 2015-10-22 | President And Fellows Of Harvard College | Systems and methods for barcoding nucleic acids |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| CN113249435B (zh) | 2014-06-26 | 2024-09-03 | 10X基因组学有限公司 | 分析来自单个细胞或细胞群体的核酸的方法 |
| MX2016016904A (es) | 2014-06-26 | 2017-03-27 | 10X Genomics Inc | Analisis de secuencias de acidos nucleicos. |
| US10697007B2 (en) | 2014-06-27 | 2020-06-30 | The Regents Of The University Of California | PCR-activated sorting (PAS) |
| CN112029826B (zh) | 2014-07-30 | 2025-03-14 | 哈佛学院院长及董事 | 用于测定核酸的系统和方法 |
| US10900065B2 (en) * | 2014-11-14 | 2021-01-26 | University Of Washington | Methods and kits for labeling cellular molecules |
| JP2017537645A (ja) * | 2014-12-19 | 2017-12-21 | アプライズ バイオ， インコーポレイテッド | 細胞の選択された部分集団中の複数エピトープを識別するための方法 |
| SG11201705615UA (en) | 2015-01-12 | 2017-08-30 | 10X Genomics Inc | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
| CN115011670A (zh) * | 2015-02-04 | 2022-09-06 | 加利福尼亚大学董事会 | 通过在离散实体中条形码化对核酸进行测序 |
| SG10202104816QA (en) * | 2015-02-10 | 2021-06-29 | Illumina Inc | Methods and compositions for analyzing cellular components |
| EP4286516A3 (en) | 2015-02-24 | 2024-03-06 | 10X Genomics, Inc. | Partition processing methods and systems |
| WO2016145416A2 (en) * | 2015-03-11 | 2016-09-15 | The Broad Institute, Inc. | Proteomic analysis with nucleic acid identifiers |
| US20160289769A1 (en) * | 2015-03-30 | 2016-10-06 | Verily Life Sciences Llc | Methods for Combining Single Cell Profiling with Combinatorial Nanoparticle Conjugate Library Screening and In Vivo Diagnostic System |
| WO2016160844A2 (en) * | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| US20160298187A1 (en) * | 2015-04-08 | 2016-10-13 | Verily Life Sciences Llc | Methods of tagging particles for multiplexed functional screening |
| AU2016253964B2 (en) * | 2015-04-27 | 2022-07-07 | Abvitro Llc | Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens |
| WO2017015099A1 (en) | 2015-07-17 | 2017-01-26 | Nanostring Technologies, Inc. | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
| EP3325649B1 (en) | 2015-07-17 | 2024-01-03 | Nanostring Technologies, Inc. | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
| US11092607B2 (en) | 2015-10-28 | 2021-08-17 | The Board Institute, Inc. | Multiplex analysis of single cell constituents |
| US11371094B2 (en) | 2015-11-19 | 2022-06-28 | 10X Genomics, Inc. | Systems and methods for nucleic acid processing using degenerate nucleotides |
| WO2017117358A1 (en) * | 2015-12-30 | 2017-07-06 | Bio-Rad Laboratories, Inc. | Digital protein quantification |
| US10900974B2 (en) * | 2016-03-22 | 2021-01-26 | California Institute Of Technology | Methods for identifying macromolecule interactions |
| WO2017190020A1 (en) * | 2016-04-28 | 2017-11-02 | The Scripps Research Institute | Oligonucleotide conjugates and uses thereof |
| AU2017266299A1 (en) * | 2016-05-17 | 2018-12-20 | Dname-It Nv | Methods for identification of samples |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| CA3034924C (en) | 2016-09-26 | 2025-11-18 | Becton, Dickinson And Company | MEASUREMENT OF PROTEIN EXPRESSION USING REAGENTS WITH BARCODED OLIGONUCLEOTIDE SEQUENCES |
| US20190276881A1 (en) * | 2016-11-08 | 2019-09-12 | President And Fellows Of Harvard College | Multiplexed imaging using merfish, expansion microscopy, and related technologies |
| DE202017007364U1 (de) * | 2016-12-16 | 2021-02-11 | The Brigham And Women's Hospital Inc. | Anordnung markierter Sensorelemente zum Erfassen unterschiedlicher Proteine, die unterschiedliche Sensorelemente binden |
| US20210072255A1 (en) | 2016-12-16 | 2021-03-11 | The Brigham And Women's Hospital, Inc. | System and method for protein corona sensor array for early detection of diseases |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| JP7033602B2 (ja) * | 2017-01-27 | 2022-03-10 | エフ．ホフマン－ラ ロシュ アーゲー | ロングレンジ配列決定のためのバーコードを付けられたｄｎａ |
| CN110214186B (zh) | 2017-01-30 | 2023-11-24 | 10X基因组学有限公司 | 用于基于微滴的单细胞条形编码的方法和系统 |
| US12264411B2 (en) | 2017-01-30 | 2025-04-01 | 10X Genomics, Inc. | Methods and systems for analysis |
| EP3583214B1 (en) | 2017-02-02 | 2023-11-22 | New York Genome Center, Inc. | Methods and compositions for identifying or quantifying targets in a biological sample |
| US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
| CN109526228B (zh) | 2017-05-26 | 2022-11-25 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
| US10844372B2 (en) | 2017-05-26 | 2020-11-24 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| WO2018218150A1 (en) | 2017-05-26 | 2018-11-29 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| JP7536450B2 (ja) | 2017-06-05 | 2024-08-20 | ベクトン・ディキンソン・アンド・カンパニー | 単一細胞用のサンプルインデックス付加 |
| CN111386351A (zh) | 2017-09-22 | 2020-07-07 | 华盛顿大学 | 细胞分子的原位组合标记 |
| EP3954782A1 (en) | 2017-11-15 | 2022-02-16 | 10X Genomics, Inc. | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| WO2019113506A1 (en) | 2017-12-07 | 2019-06-13 | The Broad Institute, Inc. | Methods and compositions for multiplexing single cell and single nuclei sequencing |
| CN118547046A (zh) | 2017-12-22 | 2024-08-27 | 10X基因组学有限公司 | 用于处理来自一个或多个细胞的核酸分子的系统和方法 |
| KR20250161650A (ko) | 2018-02-12 | 2025-11-17 | 브루커 스페이셜 바이올로지, 인크. | 유전자 및 단백질 발현을 검출하는 생체 분자 프로브 및 방법 |
| WO2019157529A1 (en) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
| CN112262218B (zh) | 2018-04-06 | 2024-11-08 | 10X基因组学有限公司 | 用于单细胞处理中的质量控制的系统和方法 |
| CA3097976A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| AU2019274469A1 (en) * | 2018-05-21 | 2020-11-26 | The Regents Of The University Of California | Single cell mapping and transcriptome analysis |
| US20200032335A1 (en) | 2018-07-27 | 2020-01-30 | 10X Genomics, Inc. | Systems and methods for metabolome analysis |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| US11828684B2 (en) | 2018-09-17 | 2023-11-28 | California Institute Of Technology | Detection of molecular associations |
| US11078480B2 (en) * | 2018-09-19 | 2021-08-03 | California Institute Of Technology | High-throughput identification of intermolecular interactions |
| ES2992135T3 (es) | 2018-10-01 | 2024-12-09 | Becton Dickinson Co | Determinar secuencias de transcripción 5 |
| KR20230155589A (ko) | 2018-11-07 | 2023-11-10 | 시어 인코퍼레이티드 | 단백질 코로나 분석을 위한 조성물, 방법 및 시스템 및 그것들의 용도 |
| WO2020117914A1 (en) * | 2018-12-04 | 2020-06-11 | Roche Sequencing Solutions, Inc. | Spatially oriented quantum barcoding of cellular targets |
| US11459607B1 (en) | 2018-12-10 | 2022-10-04 | 10X Genomics, Inc. | Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes |
| SG11202105441WA (en) | 2018-12-13 | 2021-06-29 | Dna Script | Direct oligonucleotide synthesis on cells and biomolecules |
| CA3122569A1 (en) | 2018-12-13 | 2020-06-18 | President And Fellows Of Harvard College | Amplification methods and systems for merfish and other applications |
| US20200209229A1 (en) * | 2018-12-27 | 2020-07-02 | Bio-Rad Laboratories, Inc. | Sequential multiplex western blotting |
| US11845983B1 (en) | 2019-01-09 | 2023-12-19 | 10X Genomics, Inc. | Methods and systems for multiplexing of droplet based assays |
| EP4242322B1 (en) | 2019-01-23 | 2024-08-21 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
| WO2020185312A2 (en) | 2019-01-25 | 2020-09-17 | President And Fellows Of Harvard College | Compositions and method for synthesizing nucleic acids |
| US11634766B2 (en) * | 2019-02-04 | 2023-04-25 | The Broad Institute, Inc. | Methods and compositions for analyzing nucleic acids |
| US11851683B1 (en) | 2019-02-12 | 2023-12-26 | 10X Genomics, Inc. | Methods and systems for selective analysis of cellular samples |
| CN113454234B (zh) | 2019-02-14 | 2025-03-18 | 贝克顿迪金森公司 | 杂合体靶向和全转录物组扩增 |
| JP7518852B2 (ja) | 2019-03-26 | 2024-07-18 | シアー， インコーポレイテッド | 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用 |
| WO2020214642A1 (en) * | 2019-04-19 | 2020-10-22 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
| CN114126476B (zh) | 2019-04-23 | 2025-09-09 | Encodia公司 | 用于蛋白质的空间分析的方法及相关试剂盒 |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| CN117169534A (zh) | 2019-08-05 | 2023-12-05 | 禧尔公司 | 用于样品制备、数据生成和蛋白质冠分析的系统和方法 |
| US12235262B1 (en) | 2019-09-09 | 2025-02-25 | 10X Genomics, Inc. | Methods and systems for single cell protein analysis |
| US12252741B2 (en) | 2019-10-28 | 2025-03-18 | Pixelgen Technologies Ab | Method for mapping rolling circle amplification products |
| JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長ｖ（ｄ）ｊ情報を得るためのランダムプライミングの使用 |
| CN110819656B (zh) * | 2019-11-11 | 2021-06-04 | 中国科学院上海高等研究院 | 一种基于同步光源的x-射线多色遗传标记探针及其制备方法以及应用 |
| US12163189B2 (en) | 2019-11-27 | 2024-12-10 | University Of Washington | Method for preparation and high-throughput microbial single-cell RNA sequencing of bacteria |
| US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
| EP4090764A1 (en) | 2020-01-13 | 2022-11-23 | Becton, Dickinson and Company | Cell capture using du-containing oligonucleotides |
| EP4090464A1 (en) | 2020-01-17 | 2022-11-23 | F. Hoffmann-La Roche AG | Microfluidic device and method for automated split-pool synthesis |
| US12165747B2 (en) | 2020-01-23 | 2024-12-10 | The Broad Institute, Inc. | Molecular spatial mapping of metastatic tumor microenvironment |
| WO2021155057A1 (en) | 2020-01-29 | 2021-08-05 | Becton, Dickinson And Company | Barcoded wells for spatial mapping of single cells through sequencing |
| EP4111168A1 (en) | 2020-02-25 | 2023-01-04 | Becton Dickinson and Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| EP4121528A1 (en) | 2020-03-17 | 2023-01-25 | F. Hoffmann-La Roche AG | Method of improving cell recovery in single-cell analysis |
| EP4142939A1 (en) | 2020-05-01 | 2023-03-08 | F. Hoffmann-La Roche AG | Sample collection tray for multi-well plates |
| US20230242971A1 (en) | 2020-05-08 | 2023-08-03 | Roche Sequencing Solutions, Inc. | Removal of excess oligonucleotides from a reation mixture |
| EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
| US12157913B2 (en) | 2020-06-02 | 2024-12-03 | Becton, Dickinson And Company | Oligonucleotides and beads for 5 prime gene expression assay |
| WO2021249816A1 (en) | 2020-06-08 | 2021-12-16 | F. Hoffmann-La Roche Ag | Method of single-cell analysis of multiple samples |
| US20230340578A1 (en) | 2020-07-08 | 2023-10-26 | Roche Sequencing Solutions, Inc. | Spatial analysis of multiple targets in tissue samples |
| WO2022008641A1 (en) | 2020-07-08 | 2022-01-13 | Roche Sequencing Solutions, Inc. | Split-pool synthesis apparatus and methods of performing split-pool synthesis |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| JP2023540904A (ja) | 2020-08-25 | 2023-09-27 | シアー， インコーポレイテッド | タンパク質および核酸をアッセイするための組成物および方法 |
| US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| US12378596B2 (en) | 2020-12-03 | 2025-08-05 | Roche Sequencing Solutions, Inc. | Whole transcriptome analysis in single cells |
| EP4263859A1 (en) | 2020-12-15 | 2023-10-25 | Becton, Dickinson and Company | Single cell secretome analysis |
| US20240125797A1 (en) * | 2021-01-26 | 2024-04-18 | CZ Biohub SF, LL | Quantification of cellular proteins using barcoded binding moieties |
| CN120158497A (zh) | 2021-02-23 | 2025-06-17 | 10X基因组学有限公司 | 基于探针的核酸和蛋白质分析 |
| CN113189078B (zh) * | 2021-03-04 | 2024-04-16 | 吉林大学 | 一种靶向药物的高通量筛选方法 |
| EP4303315B1 (en) | 2021-03-30 | 2024-11-06 | Pixelgen Technologies Ab | Spatial mapping by serial primer extension |
| WO2022235764A1 (en) | 2021-05-05 | 2022-11-10 | Singular Genomics Systems, Inc. | Multiomic analysis device and methods of use thereof |
| EP4430206A1 (en) | 2021-11-10 | 2024-09-18 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
| US12043862B2 (en) | 2021-12-28 | 2024-07-23 | Encodia, Inc. | High-throughput serotyping and antibody profiling assays |
| WO2023183881A2 (en) | 2022-03-24 | 2023-09-28 | Digital Biology Inc. | Tissue spatial omics |
| EP4558647A2 (en) * | 2022-07-19 | 2025-05-28 | Digital Biology Inc. | Barcode diffusion-based spatial omics |
| US20240384325A1 (en) * | 2023-05-16 | 2024-11-21 | California Institute Of Technology | Split and pool identification of rbp targets (spidr) |
Family Cites Families (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| JP2955759B2 (ja) | 1988-07-20 | 1999-10-04 | セゲブ・ダイアグノスティックス・インコーポレイテッド | 核酸配列を増幅及び検出する方法 |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| DE69118930T2 (de) | 1990-01-26 | 1997-01-09 | Abbott Lab | Verbessertes Verfahren zur Amplifikation von Nuklein säurezielsequenz, einsetzbar für die Polymerase und Ligasekettenreaktion |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| WO1996036736A2 (en) | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Wide dynamic range nucleic acid detection using an aggregate primer series |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| US6180340B1 (en) | 1997-10-31 | 2001-01-30 | Gen-Probe Incorporated | Extended dynamic range assays |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
| US20040106110A1 (en) | 1998-07-30 | 2004-06-03 | Solexa, Ltd. | Preparation of polynucleotide arrays |
| US6221613B1 (en) | 1998-12-31 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| DE60026641T2 (de) | 1999-07-15 | 2007-01-25 | Qiagen Gmbh | Verfahren zur Trennung von teilchenförmigen Substraten aus einer Lösung indem man den Teilchenverlust minimiert |
| US6262490B1 (en) | 1999-11-05 | 2001-07-17 | Advanced Semiconductor Engineering, Inc. | Substrate strip for use in packaging semiconductor chips |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| US6625546B2 (en) | 2000-02-03 | 2003-09-23 | Nanoscale Combinatorial Synthesis, Inc. | Structure identification methods using mass measurements |
| AU3806701A (en) | 2000-02-07 | 2001-08-14 | Illumina Inc | Nucleic acid detection methods using universal priming |
| SE516272C2 (sv) | 2000-02-18 | 2001-12-10 | Ulf Landegren | Metoder och kit för analytdetektion mha proximitets-probning |
| WO2002023163A1 (en) | 2000-09-15 | 2002-03-21 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| AU2001293163A1 (en) | 2000-09-27 | 2002-04-08 | Lynx Therapeutics, Inc. | Method for determining relative abundance of nucleic acid sequences |
| US7378280B2 (en) | 2000-11-16 | 2008-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
| DE10120797B4 (de) | 2001-04-27 | 2005-12-22 | Genovoxx Gmbh | Verfahren zur Analyse von Nukleinsäureketten |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| AU2002337030A1 (en) | 2001-08-29 | 2003-03-18 | Genovoxx Gmbh | Method for analyzing nucleic acid sequences and gene expression |
| JP2003101204A (ja) | 2001-09-25 | 2003-04-04 | Nec Kansai Ltd | 配線基板及び配線基板の製造方法並びに電子部品 |
| US20030082551A1 (en) | 2001-09-28 | 2003-05-01 | Zarling David A. | High-throughput gene cloning and phenotypic screening |
| DE10246005A1 (de) | 2001-10-04 | 2003-04-30 | Genovoxx Gmbh | Gerät zur Sequenzierung von Nukleinsäuremolekülen |
| DE10149786B4 (de) | 2001-10-09 | 2013-04-25 | Dmitry Cherkasov | Oberfläche für Untersuchungen aus Populationen von Einzelmolekülen |
| US20050124022A1 (en) | 2001-10-30 | 2005-06-09 | Maithreyan Srinivasan | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US20030219801A1 (en) * | 2002-03-06 | 2003-11-27 | Affymetrix, Inc. | Aptamer base technique for ligand identification |
| DE10214395A1 (de) | 2002-03-30 | 2003-10-23 | Dmitri Tcherkassov | Verfahren zur Analyse von Einzelnukleotidpolymorphismen |
| US7108976B2 (en) | 2002-06-17 | 2006-09-19 | Affymetrix, Inc. | Complexity management of genomic DNA by locus specific amplification |
| US7294298B2 (en) | 2002-07-24 | 2007-11-13 | Tdk Corporation | Functional film for transfer having functional layer, object furnished with functional layer and process for producing the same |
| GB0222846D0 (en) | 2002-10-03 | 2002-11-06 | Choo Yen | Cell culture |
| DE10356937A1 (de) | 2002-12-09 | 2004-07-15 | Mold-Masters Ltd., Georgetown | Düsenspitze und -dichtung |
| US20040110153A1 (en) | 2002-12-10 | 2004-06-10 | Affymetrix, Inc. | Compleixity management of genomic DNA by semi-specific amplification |
| AU2003291249A1 (en) * | 2002-12-18 | 2004-07-29 | Aclara Biosciences, Inc. | Multiplexed immunohistochemical assays using molecular tags |
| WO2005003375A2 (en) | 2003-01-29 | 2005-01-13 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| EP1620568B1 (en) | 2003-04-24 | 2008-12-24 | Afshin Ahmadian | Allele-specific mutation detection assay |
| WO2005010159A2 (en) | 2003-07-17 | 2005-02-03 | Children's Hospital Medical Center | Rolling circle amplification of micro-rna samples |
| EP1725572B1 (de) | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| DE10356837A1 (de) | 2003-12-05 | 2005-06-30 | Dmitry Cherkasov | Modifizierte Nukleotide und Nukleoside |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US20050255491A1 (en) | 2003-11-13 | 2005-11-17 | Lee Frank D | Small molecule and peptide arrays and uses thereof |
| JP2007524410A (ja) | 2004-01-23 | 2007-08-30 | リングヴィテ エーエス | ポリヌクレオチドライゲーション反応の改良 |
| DE102004009704A1 (de) | 2004-02-27 | 2005-09-15 | Dmitry Cherkasov | Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung |
| US20060275923A1 (en) | 2004-03-23 | 2006-12-07 | Hammond David J | Methods for reducing the range in concentrations of analyte species in a sample |
| DE102004025744A1 (de) | 2004-05-26 | 2005-12-29 | Dmitry Cherkasov | Oberfläche für die Analysen an einzelnen Nukleinsäuremolekülen |
| DE102004025745A1 (de) | 2004-05-26 | 2005-12-15 | Cherkasov, Dmitry | Oberfläche für die Analysen an einzelnen Molekülen |
| DE102004025694A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zu hochparallelen Analysen von Nukleinsäureketten |
| DE102004025695A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zur parallelen Sequenzierung von Nukleinsäureketten |
| DE102004025746A1 (de) | 2004-05-26 | 2005-12-15 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zur hochparallelen Sequenzierung von Nukleinsäureketten |
| DE102004025696A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zu hochparallelen Analysen von Nukleinsäureketten |
| US7914987B2 (en) | 2004-06-14 | 2011-03-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in analyte detection using proximity probes |
| US20060002471A1 (en) | 2004-06-30 | 2006-01-05 | Lippincott Louis A | Motion estimation unit |
| US20060024711A1 (en) | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
| US7276720B2 (en) | 2004-07-19 | 2007-10-02 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US20060012793A1 (en) | 2004-07-19 | 2006-01-19 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US20060024678A1 (en) | 2004-07-28 | 2006-02-02 | Helicos Biosciences Corporation | Use of single-stranded nucleic acid binding proteins in sequencing |
| EP1838880A2 (en) | 2005-01-21 | 2007-10-03 | Third Wave Technologies, Inc. | Methods and compositions for increased dynamic range detection of nucleic acid molecules |
| DE102006012317A1 (de) | 2005-03-17 | 2007-01-18 | Cherkasov, Dmitry, Dr. | Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung |
| EP1885876A2 (de) | 2005-03-17 | 2008-02-13 | Genovoxx GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| JP5331476B2 (ja) | 2005-06-15 | 2013-10-30 | カリダ・ジェノミックス・インコーポレイテッド | 遺伝子解析および化学解析用の単分子アレイ |
| US20070020640A1 (en) * | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| US8986926B2 (en) | 2005-12-23 | 2015-03-24 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
| EP1963531B1 (en) | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| CA2643700A1 (en) | 2006-02-24 | 2007-11-22 | Callida Genomics, Inc. | High throughput genome sequencing on dna arrays |
| US8394590B2 (en) * | 2006-08-02 | 2013-03-12 | California Institute Of Technology | Capture agents and related methods and systems for detecting and/or sorting targets |
| US8603749B2 (en) | 2006-11-15 | 2013-12-10 | Biospherex, LLC | Multitag sequencing ecogenomics analysis-US |
| US20080269068A1 (en) | 2007-02-06 | 2008-10-30 | President And Fellows Of Harvard College | Multiplex decoding of sequence tags in barcodes |
| US8003312B2 (en) | 2007-02-16 | 2011-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplex cellular assays using detectable cell barcodes |
| US8090603B2 (en) | 2007-05-11 | 2012-01-03 | Fansnap, Inc. | System and method for selecting event tickets |
| EP2171099A1 (en) | 2007-06-20 | 2010-04-07 | Taag-Genetics SA | Nested multiplex amplification method for identification of multiple biological entities |
| WO2009011808A1 (en) * | 2007-07-13 | 2009-01-22 | President And Fellows Of Harvard College | Droplet-based selection |
| EP2185720A4 (en) | 2007-08-10 | 2010-09-01 | Bio Inc Primity | BIOLOGICAL CODING OF A LARGE NUMBER OF CELLS |
| US8268564B2 (en) * | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| EP2203749B1 (en) | 2007-10-05 | 2012-08-29 | Affymetrix, Inc. | Highly multiplexed particle-based assays |
| US9286439B2 (en) | 2007-12-17 | 2016-03-15 | Yeda Research And Development Co Ltd | System and method for editing and manipulating DNA |
| US8853185B2 (en) | 2008-04-09 | 2014-10-07 | Cornell University | Coferons and methods of making and using them |
| DE102008025992B4 (de) | 2008-05-30 | 2011-01-27 | Siemens Healthcare Diagnostics Gmbh | Titerplatte und Verfahren zur Detektion eines Analyten |
| US8519115B2 (en) | 2008-08-14 | 2013-08-27 | Nanostring Technologies, Inc. | Stable nanoreporters |
| CA2734868C (en) | 2008-08-26 | 2019-09-10 | Fluidigm Corporation | Assay methods for increased throughput of samples and/or targets |
| DE102008044946B4 (de) | 2008-08-29 | 2022-06-15 | Evonik Superabsorber Gmbh | Einsatz von Schaumkörpern in Oxidations-Reaktoren zur Herstellung ungesättigter Carbonsäuren |
| GB0816976D0 (en) | 2008-09-16 | 2008-10-22 | Natural Environment Res Council | Protein |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US8481698B2 (en) | 2009-03-19 | 2013-07-09 | The President And Fellows Of Harvard College | Parallel proximity ligation event analysis |
| DK3002337T3 (en) * | 2009-03-30 | 2019-02-18 | Illumina Inc | ANALYSIS OF EXPRESSION OF GENES IN SINGLE CELLS |
| EP2467479B1 (en) * | 2009-08-20 | 2016-01-06 | Population Genetics Technologies Ltd | Compositions and methods for intramolecular nucleic acid rearrangement |
| WO2011020247A1 (en) | 2009-08-21 | 2011-02-24 | Cyagen Biosciences (Guangzhou) Inc. | Replica barcode selection assay |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US8648016B2 (en) | 2010-02-08 | 2014-02-11 | Robert Bosch Gmbh | Array with extended dynamic range and associated method |
| US10787701B2 (en) * | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20140186827A1 (en) | 2010-05-14 | 2014-07-03 | Fluidigm, Inc. | Assays for the detection of genotype, mutations, and/or aneuploidy |
| WO2011146942A1 (en) | 2010-05-21 | 2011-11-24 | The Translational Genomics Research Institute | Methods and kits to analyze microrna by nucleic acid sequencing |
| US9696332B2 (en) | 2010-07-23 | 2017-07-04 | Matrix Technologies Llc | Automated liquid handling device |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP2625320B1 (en) * | 2010-10-08 | 2019-03-27 | President and Fellows of Harvard College | High-throughput single cell barcoding |
| CN103502448B (zh) | 2010-11-12 | 2017-03-29 | Gen9股份有限公司 | 核酸合成的方法和设备 |
| WO2012083225A2 (en) | 2010-12-16 | 2012-06-21 | Gigagen, Inc. | System and methods for massively parallel analysis of nycleic acids in single cells |
| US10982271B2 (en) | 2011-01-31 | 2021-04-20 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US20200157603A1 (en) | 2011-01-31 | 2020-05-21 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US11560585B2 (en) | 2011-01-31 | 2023-01-24 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| JP6069224B2 (ja) | 2011-01-31 | 2017-02-01 | アプライズ バイオ， インコーポレイテッド | 細胞において複数のエピトープを同定する方法 |
| US10995362B2 (en) | 2011-01-31 | 2021-05-04 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| WO2012142242A2 (en) | 2011-04-12 | 2012-10-18 | Siloam Biosciences, Inc. | Assay method for extended dynamic range |
| WO2013137737A1 (en) | 2012-03-16 | 2013-09-19 | Flexgen B.V. | Methods of creating and screening of dna encoded combinatorial libraries of chemical antibodies |
| EP2882868B1 (en) | 2012-08-08 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Increasing dynamic range for identifying multiple epitopes in cells |
| CN103730314A (zh) | 2012-10-12 | 2014-04-16 | 无锡慧明电子科技有限公司 | 一种气体离子源进气实时控制系统 |
| CA2895155C (en) | 2012-12-17 | 2021-07-06 | President And Fellows Of Harvard College | Rna-guided human genome engineering |
| WO2015035087A1 (en) | 2013-09-04 | 2015-03-12 | Fluidigm Corporation | Proximity assays for detecting nucleic acids and proteins in a single cell |
| GB201401885D0 (en) | 2014-02-04 | 2014-03-19 | Olink Ab | Proximity assay with detection based on hybridisation chain reaction (HCR) |
| US10900065B2 (en) | 2014-11-14 | 2021-01-26 | University Of Washington | Methods and kits for labeling cellular molecules |
| JP2017537645A (ja) | 2014-12-19 | 2017-12-21 | アプライズ バイオ， インコーポレイテッド | 細胞の選択された部分集団中の複数エピトープを識別するための方法 |
| CN206096158U (zh) | 2016-09-19 | 2017-04-12 | 清华大学 | 自动液体处理系统 |
| US20180089373A1 (en) | 2016-09-23 | 2018-03-29 | Driver, Inc. | Integrated systems and methods for automated processing and analysis of biological samples, clinical information processing and clinical trial matching |
| WO2018213591A1 (en) | 2017-05-19 | 2018-11-22 | Counsyl, Inc. | Modular robotic system for laboratory diagnostics |
-
2012
- 2012-01-31 JP JP2013551435A patent/JP6069224B2/ja active Active
- 2012-01-31 ES ES12741485.2T patent/ES2687761T3/es active Active
- 2012-01-31 CN CN201280016828.5A patent/CN103703143B/zh active Active
- 2012-01-31 US US13/981,711 patent/US10144950B2/en active Active
- 2012-01-31 EP EP12741485.2A patent/EP2670863B1/en active Active
- 2012-01-31 WO PCT/US2012/023411 patent/WO2012106385A2/en not_active Ceased
-
2017
- 2017-05-17 US US15/597,917 patent/US10626442B2/en active Active
-
2018
- 2018-09-28 US US16/147,250 patent/US10982256B2/en active Active
-
2020
- 2020-02-19 US US16/795,203 patent/US20200208197A1/en not_active Abandoned
- 2020-10-15 US US17/071,917 patent/US12065690B2/en active Active
-
2022
- 2022-07-21 US US17/870,697 patent/US11566278B2/en active Active
- 2022-07-21 US US17/870,641 patent/US11512341B1/en active Active
- 2022-09-22 US US17/951,008 patent/US11732290B2/en active Active
- 2022-09-22 US US17/951,013 patent/US11667956B2/en active Active
- 2022-09-22 US US17/951,003 patent/US11634752B2/en active Active
- 2022-12-21 US US18/086,369 patent/US11708599B2/en active Active
- 2022-12-21 US US18/086,383 patent/US11692214B2/en active Active
-
2023
- 2023-01-26 US US18/102,056 patent/US11859240B2/en active Active
- 2023-04-12 US US18/134,003 patent/US11781171B1/en active Active
- 2023-08-11 US US18/233,221 patent/US11932903B2/en active Active
- 2023-08-11 US US18/233,214 patent/US11932902B2/en active Active
- 2023-10-12 US US18/379,589 patent/US11939624B2/en active Active
- 2023-10-12 US US18/379,586 patent/US11926864B1/en active Active
-
2024
- 2024-02-15 US US18/443,208 patent/US20240182949A1/en active Pending
- 2024-04-09 US US18/630,941 patent/US12110536B2/en active Active
- 2024-05-29 US US18/677,555 patent/US12129512B2/en active Active
- 2024-05-30 US US18/679,053 patent/US12129513B1/en active Active
- 2024-08-13 US US18/803,324 patent/US12173353B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014513916A5 (https=) | ||
| AU2023203512B2 (en) | Measurement of protein expression using reagents with barcoded oligonucleotide sequences | |
| JP6069224B2 (ja) | 細胞において複数のエピトープを同定する方法 | |
| US11161087B2 (en) | Methods and compositions for tagging and analyzing samples | |
| US20230081326A1 (en) | Increasing dynamic range for identifying multiple epitopes in cells | |
| JP2021501577A5 (https=) | ||
| CN110475864A (zh) | 用于识别或量化在生物样品中的靶标的方法和组合物 | |
| JP2015525575A5 (https=) | ||
| DK2857527T3 (en) | Enrichment and identification of fetal cells in maternal blood and ligands for such use | |
| JP2015506699A5 (https=) | ||
| JP2011137830A5 (https=) | ||
| IL296435A (en) | Single-cell combinatorial indexed cytometry sequencing | |
| Konthur et al. | High-throughput applications of phage display in proteomic analyses | |
| WO2022188054A1 (en) | Methods and reagents for sample multiplexing for high throughput single-cell rna sequencing | |
| US20250034636A1 (en) | Single-cell culture and sequencing with lipid-modified oligos | |
| Van Phan | Simultaneous Quantification of Gene Expression, Protein and Protein Complex in Single Cells | |
| Yang et al. | Detection of> 400 CD Biomarkers and Pathway Proteins in Single Immune Cells by Cyclic MIST for Single-Cell Proteomic Studies | |
| CN120775952A (zh) | 基于双微球的单细胞转录组与蛋白质组共分析方法 | |
| US20230193245A1 (en) | Methods and compositions for making and using peptide arrays | |
| WO2025097072A2 (en) | Methods and compositions for analyzing cells and their constituents | |
| JP2023554399A (ja) | マイクロ流体方法及びシステム | |
| CN103983793A (zh) | 一种含丽春红的蛋白质芯片点样缓冲液及其制备方法 | |
| Diamante et al. | Bead surface display for affinity screening of protein and peptide binders | |
| Schmidt | Development of a versatile single-molecule sensitive antibody array platform for detection of Tuberculosis Antigen | |
| Nilsson | Antigen and antibody based plasma and CSF profiling within the Human Protein Atlas |