JP2021501577A5 - - Google Patents
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- JP2021501577A5 JP2021501577A5 JP2020524114A JP2020524114A JP2021501577A5 JP 2021501577 A5 JP2021501577 A5 JP 2021501577A5 JP 2020524114 A JP2020524114 A JP 2020524114A JP 2020524114 A JP2020524114 A JP 2020524114A JP 2021501577 A5 JP2021501577 A5 JP 2021501577A5
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- nucleic acid
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 175
- 239000000126 substance Substances 0.000 claims description 115
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 101
- 229920001184 polypeptide Polymers 0.000 claims description 83
- 229920002521 macromolecule Polymers 0.000 claims description 60
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 52
- 239000007787 solid Substances 0.000 claims description 51
- 239000011230 binding agent Substances 0.000 claims description 47
- 150000007523 nucleic acids Chemical class 0.000 claims description 45
- 108020004707 nucleic acids Proteins 0.000 claims description 43
- 102000039446 nucleic acids Human genes 0.000 claims description 43
- 102000004169 proteins and genes Human genes 0.000 claims description 37
- 108090000623 proteins and genes Proteins 0.000 claims description 37
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 33
- 239000012634 fragment Substances 0.000 claims description 28
- 238000004458 analytical method Methods 0.000 claims description 23
- 239000012491 analyte Substances 0.000 claims description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims description 19
- 125000000539 amino acid group Chemical group 0.000 claims description 7
- 238000009396 hybridization Methods 0.000 claims description 5
- 230000004481 post-translational protein modification Effects 0.000 claims description 5
- 230000002000 scavenging effect Effects 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
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- 230000000295 complement effect Effects 0.000 claims 2
- 229920000642 polymer Polymers 0.000 description 286
- 238000000034 method Methods 0.000 description 181
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- 238000012163 sequencing technique Methods 0.000 description 24
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- 125000006850 spacer group Chemical group 0.000 description 10
- 108020004414 DNA Proteins 0.000 description 9
- 108010085220 Multiprotein Complexes Proteins 0.000 description 8
- 102000007474 Multiprotein Complexes Human genes 0.000 description 8
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- 102000004400 Aminopeptidases Human genes 0.000 description 5
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- 101800001415 Bri23 peptide Proteins 0.000 description 2
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- 108010016626 Dipeptides Proteins 0.000 description 2
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- 108090000364 Ligases Proteins 0.000 description 2
- 108010006035 Metalloproteases Proteins 0.000 description 2
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- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
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- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 1
- OVOJUAKDTOOXRF-UHFFFAOYSA-N 2,4-dinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O OVOJUAKDTOOXRF-UHFFFAOYSA-N 0.000 description 1
- GWGBNENHEGYJSN-UHFFFAOYSA-N 2,4-dinitrobenzenesulfonic acid;hydrate Chemical compound O.OS(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O GWGBNENHEGYJSN-UHFFFAOYSA-N 0.000 description 1
- DLZKEQQWXODGGZ-KCJUWKMLSA-N 2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 DLZKEQQWXODGGZ-KCJUWKMLSA-N 0.000 description 1
- BAILAVMHWMOTOK-UHFFFAOYSA-N 2-fluoro-1-nitro-5-sulfonylcyclohexa-1,3-diene Chemical compound S(=O)(=O)=C1CC(=C(C=C1)F)[N+](=O)[O-] BAILAVMHWMOTOK-UHFFFAOYSA-N 0.000 description 1
- 102100032488 Acylamino-acid-releasing enzyme Human genes 0.000 description 1
- 108010061216 Acylaminoacyl-peptidase Proteins 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 108091008102 DNA aptamers Proteins 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010079855 Peptide Aptamers Proteins 0.000 description 1
- INOFNEWQYCGESC-UHFFFAOYSA-N acetic acid;chromen-2-one Chemical compound CC(O)=O.C1=CC=C2OC(=O)C=CC2=C1 INOFNEWQYCGESC-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
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- 238000003776 cleavage reaction Methods 0.000 description 1
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- 108091008104 nucleic acid aptamers Proteins 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579844P | 2017-10-31 | 2017-10-31 | |
| US62/579,844 | 2017-10-31 | ||
| US201762582312P | 2017-11-06 | 2017-11-06 | |
| US62/582,312 | 2017-11-06 | ||
| US201762583448P | 2017-11-08 | 2017-11-08 | |
| US62/583,448 | 2017-11-08 | ||
| PCT/US2018/058565 WO2019089836A1 (en) | 2017-10-31 | 2018-10-31 | Kits for analysis using nucleic acid encoding and/or label |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501577A JP2021501577A (ja) | 2021-01-21 |
| JP2021501577A5 true JP2021501577A5 (https=) | 2021-12-09 |
| JP7390027B2 JP7390027B2 (ja) | 2023-12-01 |
Family
ID=66333623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524114A Active JP7390027B2 (ja) | 2017-10-31 | 2018-10-31 | 核酸エンコーディングおよび／または標識を使用する解析のためのキット |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US11513126B2 (https=) |
| EP (1) | EP3704249B1 (https=) |
| JP (1) | JP7390027B2 (https=) |
| KR (1) | KR102556494B1 (https=) |
| CN (2) | CN112272703B (https=) |
| AU (1) | AU2018358057B2 (https=) |
| CA (1) | CA3081441C (https=) |
| MX (1) | MX2020004559A (https=) |
| SG (1) | SG11202003924YA (https=) |
| WO (1) | WO2019089836A1 (https=) |
Families Citing this family (84)
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