JP2014512808A5 - - Google Patents
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- JP2014512808A5 JP2014512808A5 JP2013556905A JP2013556905A JP2014512808A5 JP 2014512808 A5 JP2014512808 A5 JP 2014512808A5 JP 2013556905 A JP2013556905 A JP 2013556905A JP 2013556905 A JP2013556905 A JP 2013556905A JP 2014512808 A5 JP2014512808 A5 JP 2014512808A5
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- Japan
- Prior art keywords
- proteins
- disease
- transcription factor
- mammal
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 28
- 102000004169 proteins and genes Human genes 0.000 claims 23
- 102000040945 Transcription factor Human genes 0.000 claims 14
- 108091023040 Transcription factor Proteins 0.000 claims 14
- 239000003446 ligand Substances 0.000 claims 14
- 102000040430 polynucleotide Human genes 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 13
- 239000002157 polynucleotide Substances 0.000 claims 13
- 241000124008 Mammalia Species 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 11
- 102000003951 Erythropoietin Human genes 0.000 claims 9
- 108090000394 Erythropoietin Proteins 0.000 claims 9
- 229940105423 erythropoietin Drugs 0.000 claims 9
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 9
- 230000001419 dependent effect Effects 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 7
- 208000002815 pulmonary hypertension Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 241000702421 Dependoparvovirus Species 0.000 claims 4
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims 4
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 claims 4
- 102000003996 Interferon-beta Human genes 0.000 claims 4
- 108090000467 Interferon-beta Proteins 0.000 claims 4
- 239000012190 activator Substances 0.000 claims 4
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims 4
- 229960001388 interferon-beta Drugs 0.000 claims 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims 3
- 206010019860 Hereditary angioedema Diseases 0.000 claims 3
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 102100027637 Plasma protease C1 inhibitor Human genes 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000002685 pulmonary effect Effects 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 102000011690 Adiponectin Human genes 0.000 claims 2
- 108010076365 Adiponectin Proteins 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 101710085045 B2 bradykinin receptor Proteins 0.000 claims 2
- 102400000967 Bradykinin Human genes 0.000 claims 2
- 101800004538 Bradykinin Proteins 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 102000003814 Interleukin-10 Human genes 0.000 claims 2
- 108090000174 Interleukin-10 Proteins 0.000 claims 2
- 102000016267 Leptin Human genes 0.000 claims 2
- 108010092277 Leptin Proteins 0.000 claims 2
- 208000031964 Other metabolic disease Diseases 0.000 claims 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 claims 2
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 229940076144 interleukin-10 Drugs 0.000 claims 2
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 2
- 229940039781 leptin Drugs 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 206010003178 Arterial thrombosis Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108010028774 Complement C1 Proteins 0.000 claims 1
- 102100025406 Complement C1s subcomponent Human genes 0.000 claims 1
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 claims 1
- 101000975003 Homo sapiens Kallistatin Proteins 0.000 claims 1
- 101001077723 Homo sapiens Serine protease inhibitor Kazal-type 6 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 229940127379 Kallikrein Inhibitors Drugs 0.000 claims 1
- 229940122920 Kallikrein inhibitor Drugs 0.000 claims 1
- 102100023012 Kallistatin Human genes 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 208000031467 Pulmonary capillary hemangiomatosis Diseases 0.000 claims 1
- 206010068690 Pulmonary vein occlusion Diseases 0.000 claims 1
- 208000014777 Pulmonary venoocclusive disease Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000007214 atherothrombosis Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 229940009550 c1 esterase inhibitor Drugs 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 239000002329 esterase inhibitor Substances 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 238000005534 hematocrit Methods 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 208000018875 hypoxemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000005980 lung dysfunction Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 201000008312 primary pulmonary hypertension Diseases 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 210000001147 pulmonary artery Anatomy 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449536P | 2011-03-04 | 2011-03-04 | |
| US61/449,536 | 2011-03-04 | ||
| US201161478881P | 2011-04-25 | 2011-04-25 | |
| US61/478,881 | 2011-04-25 | ||
| US201161490535P | 2011-05-26 | 2011-05-26 | |
| US61/490,535 | 2011-05-26 | ||
| US201161562342P | 2011-11-21 | 2011-11-21 | |
| US61/562,342 | 2011-11-21 | ||
| PCT/US2012/027515 WO2012122025A2 (en) | 2011-03-04 | 2012-03-02 | Vectors conditionally expressing protein |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044305A Division JP2017141245A (ja) | 2011-03-04 | 2017-03-08 | タンパク質を条件的に発現するベクター |
| JP2017125428A Division JP2017212995A (ja) | 2011-03-04 | 2017-06-27 | タンパク質を条件的に発現するベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512808A JP2014512808A (ja) | 2014-05-29 |
| JP2014512808A5 true JP2014512808A5 (cg-RX-API-DMAC7.html) | 2015-04-16 |
| JP6189754B2 JP6189754B2 (ja) | 2017-08-30 |
Family
ID=46798719
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013556905A Expired - Fee Related JP6189754B2 (ja) | 2011-03-04 | 2012-03-02 | タンパク質を条件的に発現するベクター |
| JP2017044305A Withdrawn JP2017141245A (ja) | 2011-03-04 | 2017-03-08 | タンパク質を条件的に発現するベクター |
| JP2017125428A Withdrawn JP2017212995A (ja) | 2011-03-04 | 2017-06-27 | タンパク質を条件的に発現するベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017044305A Withdrawn JP2017141245A (ja) | 2011-03-04 | 2017-03-08 | タンパク質を条件的に発現するベクター |
| JP2017125428A Withdrawn JP2017212995A (ja) | 2011-03-04 | 2017-06-27 | タンパク質を条件的に発現するベクター |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9402919B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3450568A3 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6189754B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103534355A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012225749B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2828411A1 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201600912SA (cg-RX-API-DMAC7.html) |
| TW (1) | TWI582108B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012122025A2 (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013158871A1 (en) * | 2012-04-20 | 2013-10-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of erythropoietin and derivatives for treating hypertension |
| LT3133923T (lt) * | 2014-04-24 | 2020-08-25 | University Of Florida Research Foundation, Inc. | Aav pagrindo genų terapija, skirta išsėtinei sklerozei |
| WO2015164723A1 (en) * | 2014-04-25 | 2015-10-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treating metastatic breast cancer and other cancers in the brain |
| CN106794243A (zh) * | 2014-08-26 | 2017-05-31 | 哈斯福制药公司 | 新型免疫剂及其使用方法 |
| JP6383621B2 (ja) * | 2014-09-24 | 2018-08-29 | 太陽インキ製造株式会社 | 硬化性組成物、ドライフィルム、硬化物、プリント配線板およびプリント配線板の製造方法 |
| CN108025047B (zh) * | 2015-05-28 | 2021-11-19 | 康奈尔大学 | 腺相关病毒介导的c1ei递送作为用于血管性水肿的疗法 |
| CA2987103A1 (en) * | 2015-05-28 | 2016-12-01 | Cornell University | Adeno-associated virus mediated delivery of c1ei as a therapy for angioedema |
| EP3347373A1 (en) | 2015-10-10 | 2018-07-18 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| JP6976244B2 (ja) | 2015-11-11 | 2021-12-08 | プレシゲン，インコーポレイテッド | 心臓状態および他の病態の処置のための複数の生物学的に活性なポリペプチドを単一のベクターから発現させるための組成物および方法 |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| EP3235516B1 (en) * | 2016-04-22 | 2019-06-26 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin | Regulatable adeno-associated virus (aav) vector |
| CN109715797A (zh) * | 2016-05-25 | 2019-05-03 | 斯坦福大学托管董事会 | 活性依赖性表达构建体以及其使用方法 |
| JP7591342B2 (ja) | 2016-06-08 | 2024-11-28 | プレシゲン，インコーポレイテッド | Ｃｄ３３特異的キメラ抗原受容体 |
| UY37343A (es) | 2016-07-25 | 2018-02-28 | Intrexon Corp | Control del fenotipo en plantas |
| BR112019009446A2 (pt) * | 2016-11-09 | 2019-07-30 | Intrexon Corp | construtos de expressão da frataxina |
| CN110462040A (zh) | 2017-01-10 | 2019-11-15 | 英特拉克森公司 | 通过新基因开关表达系统调节多肽的表达 |
| KR102557834B1 (ko) | 2017-06-07 | 2023-07-21 | 프레시전 인코포레이티드 | 신규의 세포 태그의 발현 |
| US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
| PE20212076A1 (es) | 2018-02-01 | 2021-10-26 | Homology Medicines Inc | Composiciones de virus adeno-asociado para restaurar la funcion del gen pah y metodos de uso de las mismas |
| JP7244547B2 (ja) | 2018-02-19 | 2023-03-22 | ホモロジー・メディシンズ・インコーポレイテッド | Ｆ８遺伝子機能を回復させるためのアデノ随伴ウイルス組成物及びその使用の方法 |
| KR20200128703A (ko) | 2018-03-06 | 2020-11-16 | 프레시전 인코포레이티드 | B형 간염 백신 및 이의 용도 |
| SG11202008539YA (en) | 2018-03-06 | 2020-10-29 | Precigen Inc | Human papillomavirus vaccines and uses of the same |
| US20210395773A1 (en) * | 2018-06-27 | 2021-12-23 | Precigen, Inc. | In vivo controlled combination therapy for treatment of cancer |
| WO2020014366A1 (en) * | 2018-07-10 | 2020-01-16 | Intrexon Corporation | Ror-1 specific chimeric antigen receptors and uses thereof |
| AU2020223826A1 (en) * | 2019-02-18 | 2021-08-05 | The University Of Liverpool | Method of diagnosis |
| MX2021010831A (es) | 2019-03-08 | 2021-12-15 | Obsidian Therapeutics Inc | Composiciones de ligando del cumulo de diferenciación 40 (cd40l) y métodos para regulación ajustable. |
| WO2020206056A1 (en) | 2019-04-04 | 2020-10-08 | Greenvenus Llc | Peptides and methods of plant protection |
| MX2022008415A (es) | 2020-01-08 | 2022-08-08 | Obsidian Therapeutics Inc | Composiciones y metodos para la regulacion ajustable de la transcripcion. |
| TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
| AR121837A1 (es) | 2020-04-14 | 2022-07-13 | Univ Florida | Terapias génicas basadas en aav para el tratamiento de enfermedades autoinmunes |
| EP4135852A4 (en) * | 2020-04-14 | 2024-11-20 | University Of Florida Research Foundation, Incorporated | ENHANCED EFFECTS OF GENE IMMUNOTHERAPY AND IMMUNOSUPPRESSANTS IN MULTIPLE SCLEROSIS |
| TW202208632A (zh) | 2020-05-27 | 2022-03-01 | 美商同源醫藥公司 | 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法 |
| CN112741895A (zh) * | 2021-01-19 | 2021-05-04 | 中国人民解放军陆军军医大学 | Epo类似物在制备治疗脓毒症药物中的应用 |
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-
2012
- 2012-03-02 AU AU2012225749A patent/AU2012225749B2/en not_active Ceased
- 2012-03-02 SG SG10201600912SA patent/SG10201600912SA/en unknown
- 2012-03-02 EP EP18188076.6A patent/EP3450568A3/en not_active Withdrawn
- 2012-03-02 CA CA2828411A patent/CA2828411A1/en not_active Abandoned
- 2012-03-02 US US14/001,943 patent/US9402919B2/en not_active Expired - Fee Related
- 2012-03-02 SG SG2013063045A patent/SG192856A1/en unknown
- 2012-03-02 CN CN201280021577.XA patent/CN103534355A/zh active Pending
- 2012-03-02 WO PCT/US2012/027515 patent/WO2012122025A2/en not_active Ceased
- 2012-03-02 JP JP2013556905A patent/JP6189754B2/ja not_active Expired - Fee Related
- 2012-03-02 EP EP12755403.8A patent/EP2681327B1/en not_active Not-in-force
- 2012-03-03 TW TW101107160A patent/TWI582108B/zh not_active IP Right Cessation
-
2016
- 2016-05-11 US US15/151,947 patent/US20160317678A1/en not_active Abandoned
-
2017
- 2017-03-08 JP JP2017044305A patent/JP2017141245A/ja not_active Withdrawn
- 2017-06-27 JP JP2017125428A patent/JP2017212995A/ja not_active Withdrawn
-
2018
- 2018-05-31 US US15/993,773 patent/US20180344876A1/en not_active Abandoned
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