JP2017521074A5 - - Google Patents
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- Publication number
- JP2017521074A5 JP2017521074A5 JP2017500932A JP2017500932A JP2017521074A5 JP 2017521074 A5 JP2017521074 A5 JP 2017521074A5 JP 2017500932 A JP2017500932 A JP 2017500932A JP 2017500932 A JP2017500932 A JP 2017500932A JP 2017521074 A5 JP2017521074 A5 JP 2017521074A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- bmp9
- pharmaceutical composition
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1412290.7 | 2014-07-10 | ||
| GBGB1412290.7A GB201412290D0 (en) | 2014-07-10 | 2014-07-10 | Novel use |
| PCT/GB2015/051989 WO2016005756A1 (en) | 2014-07-10 | 2015-07-09 | Therapeutic use of bone morphogenetic proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521074A JP2017521074A (ja) | 2017-08-03 |
| JP2017521074A5 true JP2017521074A5 (cg-RX-API-DMAC7.html) | 2018-08-23 |
| JP6737770B2 JP6737770B2 (ja) | 2020-08-12 |
Family
ID=51453948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500932A Active JP6737770B2 (ja) | 2014-07-10 | 2015-07-09 | 骨形成タンパク質の治療上の使用 |
Country Status (22)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| GB201603653D0 (en) * | 2016-03-02 | 2016-04-13 | Cambridge Entpr Ltd | Combination Therapy |
| AU2018214629A1 (en) * | 2017-02-06 | 2019-08-22 | Acceleron Pharma Inc. | Compositions and methods for treating heart failure |
| KR20200074201A (ko) | 2017-11-02 | 2020-06-24 | 바이엘 악티엔게젤샤프트 | Alk-1 및 bmpr-2에 결합하는 이중특이적 항체 |
| CN107760779B (zh) * | 2017-11-03 | 2020-10-16 | 中国医学科学院阜外医院 | 肺动脉高压相关的突变型bmp9基因及其应用 |
| EP3725804A4 (en) * | 2017-12-12 | 2021-10-06 | Kyowa Kirin Co., Ltd. | ANTIBODY ANTI- &XFF22; &XFF2D; &XFF30; &XFF11; &XFF10;, AND TH &XC9; RAPEUTIC AGENT AGAINST HYPERTENSION AND HYPERTENSION DISEASES WITH THIS ANTIBODY AS ACTIVE PRINCIPLE |
| CN111939245B (zh) * | 2019-05-16 | 2024-03-01 | 龚笑海 | 一种心脏治疗和保护的药物组合物 |
| EP4081240A4 (en) * | 2019-12-03 | 2023-12-06 | Acceleron Pharma Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF PULMONARY HYPERTENSION |
| KR20220021207A (ko) * | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
| WO2023012318A1 (en) * | 2021-08-05 | 2023-02-09 | Actelion Pharmaceuticals Ltd | Bmp9 variant polypeptides and uses thereof |
| CN114317604B (zh) * | 2022-03-04 | 2022-06-17 | 中国医学科学院阜外医院 | 一种自发性肺动脉高压模型及构建方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US171355A (en) * | 1875-12-21 | Improvement in driers | ||
| AU652472B2 (en) | 1991-06-25 | 1994-08-25 | Genetics Institute, Llc | BMP-9 compositions |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| AU677849B2 (en) | 1993-05-12 | 1997-05-08 | Genetics Institute, Llc | BMP-10 compositions |
| AU6787594A (en) | 1994-03-10 | 1995-09-25 | Human Genome Sciences, Inc. | Bone morphogenic protein-10 |
| AU2947395A (en) | 1995-06-06 | 1996-12-24 | Human Genome Sciences, Inc. | Bone morphogenic protein-10 |
| GB9912350D0 (en) * | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| FI117667B (fi) * | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| EP1571159A1 (en) † | 2004-03-04 | 2005-09-07 | Bayerische Julius-Maximilians-Universität Würzburg | Mutein of a bone morphogenetic protein and use thereof |
| WO2005113590A2 (en) | 2004-05-12 | 2005-12-01 | Acceleron Pharma Inc. | Bmp10 propeptides and related methods |
| WO2006130022A1 (en) | 2005-05-30 | 2006-12-07 | Agresearch Limited | Modulation of ovulation by agonists and antagonists of bmprii |
| JP2009544325A (ja) | 2006-07-27 | 2009-12-17 | セントカー・インコーポレーテツド | Ｂｍｐ−７変異体組成物、方法および使用 |
| EP3181580A1 (en) * | 2006-11-02 | 2017-06-21 | Acceleron Pharma Inc. | Alk1 receptor and ligand antagonists and uses thereof |
| WO2008151078A1 (en) * | 2007-06-01 | 2008-12-11 | Wyeth | Methods and compositions for modulating bmp-10 activity |
| US8507501B2 (en) | 2008-03-13 | 2013-08-13 | The Brigham And Women's Hospital, Inc. | Inhibitors of the BMP signaling pathway |
| WO2010114833A1 (en) | 2009-04-01 | 2010-10-07 | Indiana University Research And Technology Corporation | Methods for treating diseases using a bone morphogenetic protein |
| WO2010115874A1 (en) | 2009-04-07 | 2010-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment and the diagnosis ofpulmonary arterial hypertension |
| DK2670847T3 (en) * | 2011-02-03 | 2017-01-16 | Xoma Technology Ltd | Methods and Materials for Improving Functional Protein Expression in Bacteria |
| AU2012245439B2 (en) | 2011-04-20 | 2017-04-06 | Acceleron Pharma, Inc. | Endoglin polypeptides and uses thereof |
| US9809636B2 (en) * | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| EP2970311A4 (en) | 2013-03-14 | 2016-11-23 | Brigham & Womens Hospital | BMP HEMMER AND METHOD OF USE THEREOF |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| RS62011B1 (sr) * | 2016-07-15 | 2021-07-30 | Acceleron Pharma Inc | Kompozicije koje sadrže polipeptide actriia za upotrebu u lečenju plućne hipertenzije |
| CN107760779B (zh) | 2017-11-03 | 2020-10-16 | 中国医学科学院阜外医院 | 肺动脉高压相关的突变型bmp9基因及其应用 |
| KR20220021207A (ko) | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
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2014
- 2014-07-10 GB GBGB1412290.7A patent/GB201412290D0/en not_active Ceased
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2015
- 2015-07-09 PT PT192200665T patent/PT3669886T/pt unknown
- 2015-07-09 PL PL15739658.1T patent/PL3166628T5/pl unknown
- 2015-07-09 EP EP19220066.5A patent/EP3669886B1/en active Active
- 2015-07-09 HU HUE15739658A patent/HUE048924T2/hu unknown
- 2015-07-09 SI SI201531119T patent/SI3166628T1/sl unknown
- 2015-07-09 MX MX2017000448A patent/MX378431B/es unknown
- 2015-07-09 KR KR1020237010855A patent/KR20230049757A/ko not_active Ceased
- 2015-07-09 EP EP21158441.2A patent/EP3906936A1/en not_active Withdrawn
- 2015-07-09 RU RU2017102381A patent/RU2733318C2/ru active
- 2015-07-09 US US15/324,864 patent/US10336800B2/en active Active
- 2015-07-09 HU HUE19220066A patent/HUE054512T2/hu unknown
- 2015-07-09 JP JP2017500932A patent/JP6737770B2/ja active Active
- 2015-07-09 EP EP15739658.1A patent/EP3166628B2/en active Active
- 2015-07-09 ES ES15739658T patent/ES2770073T5/es active Active
- 2015-07-09 CN CN201580036984.1A patent/CN106661094B/zh active Active
- 2015-07-09 ES ES19220066T patent/ES2876124T3/es active Active
- 2015-07-09 SI SI201531606T patent/SI3669886T1/sl unknown
- 2015-07-09 RS RS20210631A patent/RS61961B1/sr unknown
- 2015-07-09 HR HRP20200418TT patent/HRP20200418T1/hr unknown
- 2015-07-09 LT LTEP19220066.5T patent/LT3669886T/lt unknown
- 2015-07-09 RS RS20200199A patent/RS60181B1/sr unknown
- 2015-07-09 SM SM20210323T patent/SMT202100323T1/it unknown
- 2015-07-09 CA CA2954221A patent/CA2954221C/en active Active
- 2015-07-09 PL PL19220066T patent/PL3669886T3/pl unknown
- 2015-07-09 WO PCT/GB2015/051989 patent/WO2016005756A1/en not_active Ceased
- 2015-07-09 AU AU2015287397A patent/AU2015287397B2/en active Active
- 2015-07-09 SM SM20200171T patent/SMT202000171T1/it unknown
- 2015-07-09 DK DK15739658.1T patent/DK3166628T3/da active
- 2015-07-09 KR KR1020177003531A patent/KR102519869B1/ko active Active
- 2015-07-09 LT LTEP15739658.1T patent/LT3166628T/lt unknown
- 2015-07-09 DK DK19220066.5T patent/DK3669886T3/da active
- 2015-07-09 PT PT157396581T patent/PT3166628T/pt unknown
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2017
- 2017-01-10 MX MX2020011333A patent/MX2020011333A/es unknown
- 2017-01-12 US US15/404,265 patent/US20170121383A1/en not_active Abandoned
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2019
- 2019-05-17 US US16/415,006 patent/US11572396B2/en active Active
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2020
- 2020-03-19 CY CY20201100261T patent/CY1123011T1/el unknown
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2021
- 2021-05-11 HR HRP20210734TT patent/HRP20210734T1/hr unknown
- 2021-05-14 CY CY20211100420T patent/CY1124143T1/el unknown
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2023
- 2023-01-03 US US18/149,403 patent/US20240043485A1/en not_active Abandoned