JP2014512409A - 標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその使用方法 - Google Patents

標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその使用方法 Download PDF

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JP2014512409A
JP2014512409A JP2014508125A JP2014508125A JP2014512409A JP 2014512409 A JP2014512409 A JP 2014512409A JP 2014508125 A JP2014508125 A JP 2014508125A JP 2014508125 A JP2014508125 A JP 2014508125A JP 2014512409 A JP2014512409 A JP 2014512409A
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protocell
cancer
inhibitor
protocells
seq
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JP2014512409A5 (enExample
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ジェフリー, シー. ブリンカー,
エリック, シー. カーンズ,
カーリー, エリン アシュレイ,
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UNM Rainforest Innovations
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JP2014508125A 2011-04-28 2012-04-27 標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその使用方法 Pending JP2014512409A (ja)

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US201161479847P 2011-04-28 2011-04-28
US61/479,847 2011-04-28
PCT/US2012/035529 WO2012149376A2 (en) 2011-04-28 2012-04-27 Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same

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JP2014512409A true JP2014512409A (ja) 2014-05-22
JP2014512409A5 JP2014512409A5 (enExample) 2015-06-18

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US (3) US9579283B2 (enExample)
EP (1) EP2701686A4 (enExample)
JP (1) JP2014512409A (enExample)
CN (1) CN103687590A (enExample)
AU (1) AU2012249474A1 (enExample)
CA (1) CA2834365A1 (enExample)
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Cited By (5)

* Cited by examiner, † Cited by third party
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JP2017038539A (ja) * 2015-08-18 2017-02-23 日本電信電話株式会社 脂質二分子膜基板
JP2018519347A (ja) * 2015-07-09 2018-07-19 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 融合性リポソーム被覆多孔質ケイ素ナノ粒子
JP2018527278A (ja) * 2015-07-22 2018-09-20 ルクセンブルク インスティトゥート オブ サイエンス アンド テクノロジー(リスト) 高度にアミノ化された自己集合官能化メソポーラスシリカナノ粒子及び合成方法
JP2020519648A (ja) * 2017-05-08 2020-07-02 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド 膜融合を促進するための組成物およびその使用
JP2021106889A (ja) * 2017-07-25 2021-07-29 レモネックス インコーポレイテッドLemonex Inc. 血管内生理活性物質送達用組成物

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541308B (zh) * 2006-09-28 2012-02-01 哈达斯特医疗研究服务和开发有限公司 甘油磷脂用于关节润滑的用途
US8992984B1 (en) 2009-10-21 2015-03-31 Stc.Unm Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES3005233T3 (en) 2010-10-01 2025-03-14 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
EP2701686A4 (en) 2011-04-28 2014-11-05 Stc Unm LIPID BINCHES SUPPORTED ON POROUS NANOPARTICLES (PROTOCELLS) FOR TARGETED ADMINISTRATION, AND METHODS OF USE THEREOF
CN107115314B (zh) * 2011-06-02 2022-04-29 加利福尼亚大学董事会 膜包封的纳米颗粒及使用方法
EP2734191A4 (en) 2011-07-19 2015-04-29 Stc Unm NANOVÉHICULES ADMINISTERED BY INTERPRETERONAL MOVEMENT RELEASING THEIR THERAPEUTIC LOAD ACCORDING TO THE INFLAMMATORY ENVIRONMENT OF CANCER
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
BR112014008932A2 (pt) * 2011-10-14 2019-09-24 Sandia Corp bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associados
AU2012352180A1 (en) 2011-12-16 2014-07-31 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013103614A1 (en) * 2011-12-30 2013-07-11 Stc.Unm Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all)
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9273305B1 (en) 2012-04-25 2016-03-01 Sandia Corporation Cell-based composite materials with programmed structures and functions
US10835495B2 (en) 2012-11-14 2020-11-17 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide material and methods of making and using the same
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
US20160008399A1 (en) 2013-01-14 2016-01-14 Fred Hutchinson Cancer Research Center Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse
WO2014138278A1 (en) 2013-03-05 2014-09-12 The Regents Of The University Of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
CN105246468A (zh) 2013-03-14 2016-01-13 阿布拉科斯生物科学有限公司 治疗膀胱癌的方法
US20140271815A1 (en) * 2013-03-15 2014-09-18 Aryo Sorayya Heat-and freeze-stable vaccines and methods of making and using same
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US9603799B2 (en) 2013-03-15 2017-03-28 Htd Biosystems Inc. Liposomal vaccine adjuvants and methods of making and using same
US20160151482A1 (en) * 2013-04-02 2016-06-02 Stc. Unm Mesoporous alum nanoparticles as a universal platform for antigen adsorption, presentation, and delivery
CN103989631A (zh) * 2013-04-15 2014-08-20 中国人民解放军第二军医大学 萝卜硫素制剂及其制备方法和应用
CN103990130A (zh) * 2013-06-24 2014-08-20 中国人民解放军第二军医大学 介孔二氧化硅纳米制剂及其制备方法和应用
WO2014210448A1 (en) 2013-06-27 2014-12-31 The Board Of Regents Of The University Of Texas System Compositions and methods relating to myomaker-induced muscle cell fusion
WO2015042268A1 (en) * 2013-09-18 2015-03-26 Stc.Unm Core and surface modification of mesoporous silica nanoparticles to achieve cell specific targeting in vivo
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
ES3009962T3 (en) 2014-04-23 2025-03-31 Modernatx Inc Nucleic acid vaccines
WO2016013751A1 (ko) 2014-07-22 2016-01-28 주식회사 레모넥스 생리활성 물질 또는 단백질 전달용 조성물 및 이의 용도
US20160090603A1 (en) * 2014-09-30 2016-03-31 Sandia Corporation Delivery platforms for the domestication of algae and plants
CN104667290A (zh) * 2014-10-25 2015-06-03 中国科学技术大学 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用
WO2016205515A1 (en) * 2015-06-17 2016-12-22 The Curators Of The University Of Missouri GOLD NANOROD BASED DIAGNOSTIC AGENT FOR DETECTION AND QUANTIFICATION OF c-MET (HGF) RECEPTORS
LU92784B1 (en) * 2015-07-22 2017-01-31 Luxembourg Inst Of Science And Tech (List) Negatively charged self-assembling supported lipid bilayer on mesoporous silica nanoparticles, method of synthesis and use as a nanovector
MA42543A (fr) 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
WO2017041032A1 (en) * 2015-09-04 2017-03-09 Brinker C Jeffrey Protocells to treat microbial infection and for synergistic delivery
US20180344641A1 (en) * 2015-09-04 2018-12-06 C. Jeffrey Brinker Mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles for biomedical applications
ES2910425T3 (es) 2015-09-17 2022-05-12 Modernatx Inc Compuestos y composiciones para la administración intracelular de agentes terapéuticos
US10016422B2 (en) * 2015-09-30 2018-07-10 Oregon State University Nanocarrier drug delivery platform
LT3365020T (lt) * 2015-10-22 2019-10-25 Delsitech Oy Hidrogelio kompozicijos depo vaisto forma
SMT202200252T1 (it) 2015-12-22 2022-07-21 Modernatx Inc Composti e composizioni per il rilascio intracellulare di agenti
CN105456198B (zh) * 2015-12-25 2017-04-26 正大天晴药业集团股份有限公司 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法
US11696959B2 (en) 2015-12-31 2023-07-11 City Of Hope Nanoparticle-cell construct with platinum anti-cancer agent
US11672866B2 (en) 2016-01-08 2023-06-13 Paul N. DURFEE Osteotropic nanoparticles for prevention or treatment of bone metastases
KR20240064009A (ko) 2016-01-08 2024-05-10 더 리전트 오브 더 유니버시티 오브 캘리포니아 화물 전달용 지질 2중층 코팅물을 가진 메조다공성 실리카 나노입자
CN108883199A (zh) * 2016-03-16 2018-11-23 梅里麦克制药股份有限公司 肝配蛋白受体a2(epha2)的纳米脂质体靶向和相关诊断
AU2017250300B2 (en) * 2016-04-14 2023-04-06 Massachusetts Institute Of Technology Porous silicon materials comprising a metal silicate for delivery of therapeutic agents
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
US10663450B2 (en) * 2016-06-15 2020-05-26 The University Of Chicago Amorphous, porous silicon materials and related methods
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
EP4371584A3 (en) * 2016-12-21 2024-08-28 Fred Hutchinson Cancer Center Scaffolds to treat solid tumor cells and escape variants
US10874768B2 (en) * 2017-01-20 2020-12-29 Covidien Lp Drug eluting medical device
CN110475546A (zh) 2017-02-06 2019-11-19 雷莫内克斯生物制药有限公司 生理活性物质载体
US11344629B2 (en) 2017-03-01 2022-05-31 Charles Jeffrey Brinker Active targeting of cells by monosized protocells
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
CA3056133A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Crystal forms of amino lipids
SI3596041T1 (sl) 2017-03-15 2023-02-28 Modernatx, Inc. Spojina in sestavki za intracelično dostavljanje terapevtskih sredstev
WO2018187287A1 (en) * 2017-04-03 2018-10-11 Charles Jeffrey Brinker Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators
MA48047A (fr) 2017-04-05 2020-02-12 Modernatx Inc Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée
EP3638678B1 (en) 2017-06-14 2025-12-03 ModernaTX, Inc. Compounds and compositions for intracellular delivery of agents
EP3638215A4 (en) 2017-06-15 2021-03-24 Modernatx, Inc. RNA FORMULATIONS
US11007516B1 (en) 2017-06-19 2021-05-18 National Technology & Engineering Solutions Of Sandia, Llc Tunable metal-organic framework compositions and methods thereof
WO2019005830A1 (en) * 2017-06-26 2019-01-03 Fordoz Pharma Corp. NANOSOME FORMULATIONS OF APREPITANT AND METHODS AND APPLICATIONS THEREOF
WO2019046809A1 (en) 2017-08-31 2019-03-07 Modernatx, Inc. METHODS OF MANUFACTURING LIPID NANOPARTICLES
KR102152348B1 (ko) 2017-09-05 2020-09-08 주식회사 레모넥스 세포 운명 조절용 조성물
CN113616618B (zh) * 2017-09-22 2022-11-08 杭州景杰生物科技股份有限公司 利用微混合和卡培他滨两亲性特性的卡培他滨的聚合物-脂质混杂纳米颗粒
US10933027B1 (en) 2017-09-25 2021-03-02 National Technology & Engineering Solutions Of Sandia, Llc Expanded pore particles and delivery methods thereof
EP3735250A4 (en) 2018-01-01 2022-04-13 The Regents Of The University Of California INDUSTRIAL-SCALE SYNTHESIS OF SILICASOMES-TYPE NANOSUPPORTS
US20200405650A1 (en) * 2018-02-28 2020-12-31 Achraf Noureddine Starry mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles
WO2019217396A1 (en) * 2018-05-08 2019-11-14 Yale University Protein capture membrane and method of use thereof
US11045554B1 (en) 2018-06-22 2021-06-29 National Technology & Engineering Solutions Of Sandia, Llc Lipid-coated particles for treating viral infections
CN112955174A (zh) 2018-07-09 2021-06-11 旗舰先锋创新V股份有限公司 融合剂脂质体组合物和其用途
CN108938595B (zh) * 2018-07-15 2021-09-14 河南工业大学 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法
US12263248B2 (en) 2018-09-19 2025-04-01 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020068798A1 (en) 2018-09-24 2020-04-02 Guo Jimin Living mammalian cells modified with functional modular nanoparticles
US20230048166A1 (en) * 2018-11-14 2023-02-16 Flagship Pioneering Innovations V, Inc. Fusosome compositions for hematopoietic stem cell delivery
CA3120093A1 (en) 2018-11-14 2020-05-22 Flagship Pioneering Innovations V, Inc. Compositions and methods for compartment-specific cargo delivery
US12208164B2 (en) 2019-02-28 2025-01-28 Unm Rainforest Innovations Modular metal-organic polyhedra superassembly compositions
EP3938379A4 (en) 2019-03-15 2023-02-22 ModernaTX, Inc. Hiv rna vaccines
CN110120249B (zh) * 2019-05-23 2023-01-06 复旦大学 通过靶向调控动力学路径构造靶向构造目标结构的方法
CN120423969A (zh) 2019-09-19 2025-08-05 摩登纳特斯有限公司 用于治疗剂的细胞内递送的支链尾端脂质化合物和组合物
CN111529505B (zh) * 2020-03-25 2023-04-11 西安组织工程与再生医学研究所 功能性嵌合凋亡小体及其制备方法和应用
CN111529504B (zh) * 2020-03-25 2023-01-10 西安组织工程与再生医学研究所 功能性嵌合凋亡小体及其制备方法和应用
US11433121B1 (en) 2020-04-03 2022-09-06 National Technology & Engineering Solutions Of Sandia, Llc Lipid composition for the delivery of therapeutic cargos
CN111588704B (zh) * 2020-07-01 2023-04-11 西安组织工程与再生医学研究所 靶向响应性释放系统及其制备方法和应用
CN111991558B (zh) * 2020-08-28 2022-08-09 安徽贝克生物制药有限公司 一种抗逆转录病毒药物组合物及其制备方法
CN112168977A (zh) * 2020-10-27 2021-01-05 西南大学 转铁蛋白修饰的二氧化硅荷载白藜芦醇及制备方法和应用
CN112480212A (zh) * 2020-12-17 2021-03-12 中国药科大学 靶向肝细胞生长因子的高亲和肽及其应用
JP2024532963A (ja) 2021-04-08 2024-09-11 サナ バイオテクノロジー,インコーポレイテッド Cd8特異的抗体コンストラクト及びその組成物
US20230321032A1 (en) * 2022-04-06 2023-10-12 University Of Kentucky Research Foundation Functionalized mesoporous silica nanoparticles for treatment of periodontal disease
US12194458B2 (en) * 2022-08-16 2025-01-14 Nicole Shamayev Device and method of portable drug testing
US12098200B1 (en) 2022-10-12 2024-09-24 National Technology & Engineering Solutions Of Sandia, Llc Brain-targeting single domain antibodies and purification methods
WO2024182425A1 (en) * 2023-02-27 2024-09-06 Noureddine Achraf Compositions and methods for treating metabolic diseases/disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009515520A (ja) * 2005-11-10 2009-04-16 レセプター バイオロジックス, インコーポレイテッド 肝細胞成長因子イントロン融合蛋白
WO2010078569A2 (en) * 2009-01-05 2010-07-08 Stc.Unm Porous nanoparticle supported lipid bilayer nanostructures

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5277913A (en) 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
WO1994022468A1 (en) 1993-04-02 1994-10-13 Anticancer, Inc. Method for delivering beneficial compositions to hair follicles
US5820879A (en) 1993-02-12 1998-10-13 Access Pharmaceuticals, Inc. Method of delivering a lipid-coated condensed-phase microparticle composition
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
CZ20011671A3 (cs) * 1998-11-13 2001-10-17 Cyclacel Limited Peptidová nosná skupina pro transport
JP2003501488A (ja) 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
GB0104259D0 (en) * 2001-02-21 2001-04-11 Smithkline Beecham Biolog Novel compounds
WO2003016040A1 (en) 2001-04-16 2003-02-27 The Regents Of The University Of California Membrane mimetic architectures on nanoporous materials
JP2005513145A (ja) 2001-12-21 2005-05-12 セラター テクノロジーズ インコーポレイテッド 改変されたポリマー脂質送達ビヒクル
US20040005352A1 (en) 2002-04-16 2004-01-08 Lopez Gabriel P. Biologically functionalized porous microspheres
US20040101822A1 (en) 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7563451B2 (en) 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
JP5557127B2 (ja) 2005-02-14 2014-07-23 オーストラリアン ニュークリア サイエンス アンド テクノロジー オーガニゼーション 層状ナノ粒子
US7514267B1 (en) 2005-08-19 2009-04-07 Stcunm Detection systems utilizing supported lipid bilayers
US20080160313A1 (en) * 2006-04-26 2008-07-03 Gabriel Lopez Lipid bilayers on nanotextured solid surfaces
WO2007140618A1 (en) 2006-06-09 2007-12-13 Protox Therapeutics Incorporated Modified protein toxins targeting cytokine -receptor bearing cells and use thereof for treating disease
US9803189B2 (en) 2006-08-23 2017-10-31 Stc.Unm Virus-like platform for rapid vaccine discovery
US20090093551A1 (en) 2006-12-08 2009-04-09 Bhatia Sangeeta N Remotely triggered release from heatable surfaces
WO2008112565A2 (en) 2007-03-09 2008-09-18 Anthony Manganaro Method and composition for treating cancer
US9993437B2 (en) 2007-12-06 2018-06-12 The Regents Of The University Of California Mesoporous silica nanoparticles for biomedical applications
WO2009091531A2 (en) 2008-01-16 2009-07-23 The General Hospital Corporation Uniform-sized, multi-drug carrying and photosensitive liposomes for advance drug delivery
WO2009131704A2 (en) 2008-04-25 2009-10-29 Northwestern University Nanostructures suitable for sequestering cholesterol and other molecules
CN101658533A (zh) * 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送
US9732324B2 (en) 2008-10-23 2017-08-15 Cornell University Anti-viral method
WO2010056351A2 (en) 2008-11-14 2010-05-20 Stc.Unm Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and out come prediction in pedeatric b-precursor acute lymphoblastic leukemia
US8992984B1 (en) 2009-10-21 2015-03-31 Stc.Unm Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
WO2011116226A2 (en) 2010-03-17 2011-09-22 Stc.Unm Display of antibody fragments on virus-like particles of rna bacteriophages
US20110300186A1 (en) 2010-04-14 2011-12-08 Battelle Memorial Institute Functionalized Nano- and Micro-materials for Medical Therapies
EP2701686A4 (en) 2011-04-28 2014-11-05 Stc Unm LIPID BINCHES SUPPORTED ON POROUS NANOPARTICLES (PROTOCELLS) FOR TARGETED ADMINISTRATION, AND METHODS OF USE THEREOF
EP2734191A4 (en) 2011-07-19 2015-04-29 Stc Unm NANOVÉHICULES ADMINISTERED BY INTERPRETERONAL MOVEMENT RELEASING THEIR THERAPEUTIC LOAD ACCORDING TO THE INFLAMMATORY ENVIRONMENT OF CANCER
BR112014008932A2 (pt) 2011-10-14 2019-09-24 Sandia Corp bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associados
WO2013103614A1 (en) 2011-12-30 2013-07-11 Stc.Unm Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all)
US20160151482A1 (en) 2013-04-02 2016-06-02 Stc. Unm Mesoporous alum nanoparticles as a universal platform for antigen adsorption, presentation, and delivery
US20170165375A1 (en) 2013-04-02 2017-06-15 Stc. Unm Antibiotic protocells and related pharmaceutical formulations and methods of treatment
WO2015042279A1 (en) 2013-09-18 2015-03-26 Stc. Unm Torroidal mesoporous silica nanoparticles (tmsnps) and related protocells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009515520A (ja) * 2005-11-10 2009-04-16 レセプター バイオロジックス, インコーポレイテッド 肝細胞成長因子イントロン融合蛋白
WO2010078569A2 (en) * 2009-01-05 2010-07-08 Stc.Unm Porous nanoparticle supported lipid bilayer nanostructures

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAT MATER. MAY; : ., vol. 10(5), JPN6016005481, 17 April 2011 (2011-04-17), pages 389 - 397, ISSN: 0003255631 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018519347A (ja) * 2015-07-09 2018-07-19 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 融合性リポソーム被覆多孔質ケイ素ナノ粒子
JP2018527278A (ja) * 2015-07-22 2018-09-20 ルクセンブルク インスティトゥート オブ サイエンス アンド テクノロジー(リスト) 高度にアミノ化された自己集合官能化メソポーラスシリカナノ粒子及び合成方法
JP2017038539A (ja) * 2015-08-18 2017-02-23 日本電信電話株式会社 脂質二分子膜基板
JP2020519648A (ja) * 2017-05-08 2020-07-02 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド 膜融合を促進するための組成物およびその使用
JP2023153260A (ja) * 2017-05-08 2023-10-17 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド 膜融合を促進するための組成物およびその使用
JP7395355B2 (ja) 2017-05-08 2023-12-11 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド 膜融合を促進するための組成物およびその使用
JP7783858B2 (ja) 2017-05-08 2025-12-10 フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド 膜融合を促進するための組成物およびその使用
JP2021106889A (ja) * 2017-07-25 2021-07-29 レモネックス インコーポレイテッドLemonex Inc. 血管内生理活性物質送達用組成物
JP7115784B2 (ja) 2017-07-25 2022-08-09 レモネックス インコーポレイテッド 血管内生理活性物質送達用組成物

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