JP2014512409A5 - - Google Patents

Download PDF

Info

Publication number
JP2014512409A5
JP2014512409A5 JP2014508125A JP2014508125A JP2014512409A5 JP 2014512409 A5 JP2014512409 A5 JP 2014512409A5 JP 2014508125 A JP2014508125 A JP 2014508125A JP 2014508125 A JP2014508125 A JP 2014508125A JP 2014512409 A5 JP2014512409 A5 JP 2014512409A5
Authority
JP
Japan
Prior art keywords
protocell
composition according
composition
seq
protocells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014508125A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014512409A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/035529 external-priority patent/WO2012149376A2/en
Publication of JP2014512409A publication Critical patent/JP2014512409A/ja
Publication of JP2014512409A5 publication Critical patent/JP2014512409A5/ja
Pending legal-status Critical Current

Links

JP2014508125A 2011-04-28 2012-04-27 標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその使用方法 Pending JP2014512409A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161479847P 2011-04-28 2011-04-28
US61/479,847 2011-04-28
PCT/US2012/035529 WO2012149376A2 (en) 2011-04-28 2012-04-27 Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same

Publications (2)

Publication Number Publication Date
JP2014512409A JP2014512409A (ja) 2014-05-22
JP2014512409A5 true JP2014512409A5 (enExample) 2015-06-18

Family

ID=47073093

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014508125A Pending JP2014512409A (ja) 2011-04-28 2012-04-27 標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその使用方法

Country Status (7)

Country Link
US (3) US9579283B2 (enExample)
EP (1) EP2701686A4 (enExample)
JP (1) JP2014512409A (enExample)
CN (1) CN103687590A (enExample)
AU (1) AU2012249474A1 (enExample)
CA (1) CA2834365A1 (enExample)
WO (1) WO2012149376A2 (enExample)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2664944C (en) * 2006-09-28 2016-06-14 Hadasit Medical Research Services & Development Limited Use of glycerophospholipids for joint lubrication
US8992984B1 (en) 2009-10-21 2015-03-31 Stc.Unm Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2857499A1 (en) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
CN103687590A (zh) 2011-04-28 2014-03-26 Stc·Unm公司 用于靶向给药的多孔纳米颗粒支撑脂双层(原始细胞)及其使用方法
CN107115314B (zh) * 2011-06-02 2022-04-29 加利福尼亚大学董事会 膜包封的纳米颗粒及使用方法
WO2013012891A1 (en) 2011-07-19 2013-01-24 Stc. Unm Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT3682905T (pt) 2011-10-03 2022-04-07 Modernatx Inc Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
US20150272885A1 (en) * 2011-10-14 2015-10-01 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
WO2013103614A1 (en) * 2011-12-30 2013-07-11 Stc.Unm Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all)
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9273305B1 (en) 2012-04-25 2016-03-01 Sandia Corporation Cell-based composite materials with programmed structures and functions
US10835495B2 (en) 2012-11-14 2020-11-17 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide material and methods of making and using the same
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
WO2014110591A1 (en) 2013-01-14 2014-07-17 Fred Hutchinson Cancer Research Center Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse
WO2014138278A1 (en) 2013-03-05 2014-09-12 The Regents Of The University Of California Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents
JP6309610B2 (ja) 2013-03-14 2018-04-11 アブラクシス バイオサイエンス, エルエルシー 膀胱がんを処置する方法
US20140271815A1 (en) * 2013-03-15 2014-09-18 Aryo Sorayya Heat-and freeze-stable vaccines and methods of making and using same
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US9603799B2 (en) 2013-03-15 2017-03-28 Htd Biosystems Inc. Liposomal vaccine adjuvants and methods of making and using same
WO2014165617A1 (en) * 2013-04-02 2014-10-09 Stc.Unm Mesoporous alum nanoparticles as universal platform for antigen adsorption, presentation, and delivery
CN103989631A (zh) * 2013-04-15 2014-08-20 中国人民解放军第二军医大学 萝卜硫素制剂及其制备方法和应用
CN103990130A (zh) * 2013-06-24 2014-08-20 中国人民解放军第二军医大学 介孔二氧化硅纳米制剂及其制备方法和应用
WO2014210448A1 (en) 2013-06-27 2014-12-31 The Board Of Regents Of The University Of Texas System Compositions and methods relating to myomaker-induced muscle cell fusion
EP3046547A4 (en) * 2013-09-18 2017-05-24 Stc.Unm Core and surface modification of mesoporous silica nanoparticles to achieve cell specific targeting in vivo
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
HRP20220070T1 (hr) 2014-04-23 2022-04-01 Modernatx, Inc. Cjepiva nukleinske kiseline
WO2016013751A1 (ko) 2014-07-22 2016-01-28 주식회사 레모넥스 생리활성 물질 또는 단백질 전달용 조성물 및 이의 용도
US20160090603A1 (en) * 2014-09-30 2016-03-31 Sandia Corporation Delivery platforms for the domestication of algae and plants
CN104667290A (zh) * 2014-10-25 2015-06-03 中国科学技术大学 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用
WO2016205515A1 (en) * 2015-06-17 2016-12-22 The Curators Of The University Of Missouri GOLD NANOROD BASED DIAGNOSTIC AGENT FOR DETECTION AND QUANTIFICATION OF c-MET (HGF) RECEPTORS
WO2017008059A1 (en) * 2015-07-09 2017-01-12 The Regents Of The University Of California Fusogenic liposome-coated porous silicon nanoparticles
LU92784B1 (en) 2015-07-22 2017-01-31 Luxembourg Inst Of Science And Tech (List) Negatively charged self-assembling supported lipid bilayer on mesoporous silica nanoparticles, method of synthesis and use as a nanovector
LU92783B1 (en) * 2015-07-22 2017-01-31 Luxembourg Inst Of Science And Tech (List) Highly aminated self-assembling fuctionalized Mesoporous Silicia Nanoparticles and methods of synthesis
EP3328394A4 (en) 2015-07-30 2019-03-13 ModernaTX, Inc. CONCATEMEE peptide epitope RNAs
JP2017038539A (ja) * 2015-08-18 2017-02-23 日本電信電話株式会社 脂質二分子膜基板
US20190262469A1 (en) * 2015-09-04 2019-08-29 C. Jeffrey Brinker Protocells to treat microbial infection and for synergistic delivery
WO2017041033A1 (en) * 2015-09-04 2017-03-09 Brinker C Jeffrey Mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles for biomedical applications
HRP20220156T1 (hr) 2015-09-17 2022-04-15 Modernatx, Inc. Spojevi i pripravci za unutarstaničnu isporuku terapeutskih sredstava
US10016422B2 (en) * 2015-09-30 2018-07-10 Oregon State University Nanocarrier drug delivery platform
PL3365020T3 (pl) * 2015-10-22 2020-03-31 Delsitech Oy Preparat depot kompozytu hydrożelowego
EP3364949A4 (en) 2015-10-22 2019-07-31 ModernaTX, Inc. CANCER VACCINES
RS63051B1 (sr) 2015-12-22 2022-04-29 Modernatx Inc Jedinjenja i kompozicije za intracelularnu isporuku agenasa
CN105456198B (zh) * 2015-12-25 2017-04-26 正大天晴药业集团股份有限公司 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法
WO2017117275A1 (en) * 2015-12-31 2017-07-06 City Of Hope Silica nanoparticle with platinum anti-cancer agent
WO2017120504A1 (en) 2016-01-08 2017-07-13 Durfee Paul N Osteotropic nanoparticles for prevention or treatment of bone metastases
WO2017120537A1 (en) 2016-01-08 2017-07-13 The Regents Of The University Of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
JP2019512477A (ja) * 2016-03-16 2019-05-16 メリマック ファーマシューティカルズ インコーポレーティッド エフリン受容体a2(epha2)のナノリポソーム標的化及び関連する診断
CN109843301B (zh) * 2016-04-14 2022-05-27 斯宾纳克生物科学公司 用于递送治疗剂的含金属硅酸盐的多孔硅材料
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
US10663450B2 (en) * 2016-06-15 2020-05-26 The University Of Chicago Amorphous, porous silicon materials and related methods
EP3538067A1 (en) 2016-11-08 2019-09-18 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
US20190336532A1 (en) * 2016-12-21 2019-11-07 Fred Hutchinson Cancer Research Center Scaffolds to treat solid tumor cells and escape variants
US10874768B2 (en) * 2017-01-20 2020-12-29 Covidien Lp Drug eluting medical device
JP6883354B2 (ja) 2017-02-06 2021-06-09 レモネックス インコーポレイテッドLemonex Inc. 生理活性物質送達体
US11344629B2 (en) 2017-03-01 2022-05-31 Charles Jeffrey Brinker Active targeting of cells by monosized protocells
RS63953B1 (sr) 2017-03-15 2023-02-28 Modernatx Inc Jedinjenje i kompozicije za intracelularnu isporuku terapeutskih sredstava
WO2018170322A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Crystal forms of amino lipids
JP7332478B2 (ja) 2017-03-15 2023-08-23 モデルナティエックス インコーポレイテッド 脂質ナノ粒子製剤
WO2018187287A1 (en) * 2017-04-03 2018-10-11 Charles Jeffrey Brinker Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators
MA48047A (fr) 2017-04-05 2020-02-12 Modernatx Inc Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée
US11576872B2 (en) * 2017-05-08 2023-02-14 Flagship Pioneering Innovations V, Inc. Compositions for facilitating membrane fusion and uses thereof
EP3638678B1 (en) 2017-06-14 2025-12-03 ModernaTX, Inc. Compounds and compositions for intracellular delivery of agents
MA49421A (fr) 2017-06-15 2020-04-22 Modernatx Inc Formulations d'arn
US11007516B1 (en) 2017-06-19 2021-05-18 National Technology & Engineering Solutions Of Sandia, Llc Tunable metal-organic framework compositions and methods thereof
CN110996911B (zh) * 2017-06-26 2023-01-17 福多兹制药公司 阿瑞匹坦的纳米微脂囊配制品及其方法和应用
JP6865491B2 (ja) * 2017-07-25 2021-04-28 レモネックス インコーポレイテッドLemonex Inc. 血管内生理活性物質送達用組成物
MX2020002348A (es) 2017-08-31 2020-10-08 Modernatx Inc Métodos de elaboración de nanopartículas lipídicas.
KR102152348B1 (ko) 2017-09-05 2020-09-08 주식회사 레모넥스 세포 운명 조절용 조성물
WO2019057113A1 (en) * 2017-09-22 2019-03-28 Jingjie Ptm Biolab (Hangzhou) Co., Ltd. CAPECITABINE POLYMER-LIPID HYBRID NANOPARTICLES USING MICROMELIN AND AMPHIPHILIC CAPECITABINE PROPERTIES
US10933027B1 (en) 2017-09-25 2021-03-02 National Technology & Engineering Solutions Of Sandia, Llc Expanded pore particles and delivery methods thereof
EP3735250A4 (en) 2018-01-01 2022-04-13 The Regents Of The University Of California UPSCALE SYNTHESIS OF SILICASOME NANOCARRIAGES
US20200405650A1 (en) * 2018-02-28 2020-12-31 Achraf Noureddine Starry mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles
CN112292594B (zh) * 2018-05-08 2024-06-25 耶鲁大学 蛋白质捕获膜及其使用方法
US11045554B1 (en) * 2018-06-22 2021-06-29 National Technology & Engineering Solutions Of Sandia, Llc Lipid-coated particles for treating viral infections
CA3105953A1 (en) 2018-07-09 2020-01-16 Flagship Pioneering Innovations V, Inc. Fusosome compositions and uses thereof
CN108938595B (zh) * 2018-07-15 2021-09-14 河南工业大学 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法
EP3853202A1 (en) 2018-09-19 2021-07-28 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US12090235B2 (en) 2018-09-20 2024-09-17 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
US12252708B2 (en) 2018-09-24 2025-03-18 Unm Rainforest Innovations Living mammalian cells modified with functional modular nanoparticles
US20230048166A1 (en) * 2018-11-14 2023-02-16 Flagship Pioneering Innovations V, Inc. Fusosome compositions for hematopoietic stem cell delivery
KR20210131991A (ko) 2018-11-14 2021-11-03 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 구획-특이적 카고 전달을 위한 조성물 및 방법
CN113939282A (zh) 2019-01-31 2022-01-14 摩登纳特斯有限公司 制备脂质纳米颗粒的方法
WO2020176716A1 (en) 2019-02-28 2020-09-03 Brinker C Jeffrey Modular metal–organic polyhedra superassembly compositions
MA55321A (fr) 2019-03-15 2022-01-19 Modernatx Inc Vaccins à base d'arn contre le vih
CN110120249B (zh) * 2019-05-23 2023-01-06 复旦大学 通过靶向调控动力学路径构造靶向构造目标结构的方法
AU2020351220A1 (en) 2019-09-19 2022-04-07 Modernatx, Inc. Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents
EP4031524A1 (en) 2019-09-19 2022-07-27 ModernaTX, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
CN111529504B (zh) * 2020-03-25 2023-01-10 西安组织工程与再生医学研究所 功能性嵌合凋亡小体及其制备方法和应用
CN111529505B (zh) * 2020-03-25 2023-04-11 西安组织工程与再生医学研究所 功能性嵌合凋亡小体及其制备方法和应用
US11433121B1 (en) 2020-04-03 2022-09-06 National Technology & Engineering Solutions Of Sandia, Llc Lipid composition for the delivery of therapeutic cargos
CN111588704B (zh) * 2020-07-01 2023-04-11 西安组织工程与再生医学研究所 靶向响应性释放系统及其制备方法和应用
CN111991558B (zh) * 2020-08-28 2022-08-09 安徽贝克生物制药有限公司 一种抗逆转录病毒药物组合物及其制备方法
CN112168977A (zh) * 2020-10-27 2021-01-05 西南大学 转铁蛋白修饰的二氧化硅荷载白藜芦醇及制备方法和应用
CN112480212A (zh) * 2020-12-17 2021-03-12 中国药科大学 靶向肝细胞生长因子的高亲和肽及其应用
JP2024532963A (ja) 2021-04-08 2024-09-11 サナ バイオテクノロジー,インコーポレイテッド Cd8特異的抗体コンストラクト及びその組成物
CN117460542A (zh) * 2021-06-11 2024-01-26 纳米智能生物医学工程有限公司 包含用于将寡核苷酸递送至靶细胞内的肽-脂质缀合物的纳米颗粒以及包含其的药物组合物
US20230321032A1 (en) * 2022-04-06 2023-10-12 University Of Kentucky Research Foundation Functionalized mesoporous silica nanoparticles for treatment of periodontal disease
US12194458B2 (en) * 2022-08-16 2025-01-14 Nicole Shamayev Device and method of portable drug testing
US12098200B1 (en) 2022-10-12 2024-09-24 National Technology & Engineering Solutions Of Sandia, Llc Brain-targeting single domain antibodies and purification methods
WO2024182425A1 (en) * 2023-02-27 2024-09-06 Noureddine Achraf Compositions and methods for treating metabolic diseases/disorders
US12629392B2 (en) 2023-04-19 2026-05-19 Imam Abdulrahman Bin Faisal University Method of treating covid-19 infection using superparamagnetic iron oxide nanoparticle
CN120504733A (zh) * 2025-03-28 2025-08-19 江南大学 一种用于骨折修复的生物合成类i型胶原蛋白水凝胶及其制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5277913A (en) 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
US5820879A (en) 1993-02-12 1998-10-13 Access Pharmaceuticals, Inc. Method of delivering a lipid-coated condensed-phase microparticle composition
JP2950520B2 (ja) 1993-04-02 1999-09-20 アンティキャンサー インコーポレーテド 毛胞に有益な配合物を送達する方法
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
ES2318906T3 (es) * 1998-11-13 2009-05-01 Cyclacel Limited Vectores de transposicion derivados de helice 3 de homeodominio de antennapedia.
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
GB0104259D0 (en) * 2001-02-21 2001-04-11 Smithkline Beecham Biolog Novel compounds
WO2003016040A1 (en) 2001-04-16 2003-02-27 The Regents Of The University Of California Membrane mimetic architectures on nanoporous materials
WO2003055469A1 (en) 2001-12-21 2003-07-10 Celator Technologies Inc. Improved polymer-lipid delivery vehicles
US20040005352A1 (en) 2002-04-16 2004-01-08 Lopez Gabriel P. Biologically functionalized porous microspheres
US20040101822A1 (en) 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7563451B2 (en) 2003-07-22 2009-07-21 Iowa State University Research Foundation, Inc. Capped mesoporous silicates
US8871272B2 (en) 2005-02-14 2014-10-28 Australian Nuclear Science & Technology Organisation Layered nanoparticles
US7514267B1 (en) 2005-08-19 2009-04-07 Stcunm Detection systems utilizing supported lipid bilayers
AU2006315825A1 (en) 2005-11-10 2007-05-24 Receptor Biologix, Inc. Hepatocyte growth factor intron fusion proteins
US20080160313A1 (en) * 2006-04-26 2008-07-03 Gabriel Lopez Lipid bilayers on nanotextured solid surfaces
CA2657946A1 (en) 2006-06-09 2007-12-13 Protox Therapeutics Incorporated Modified protein toxins targeting cytokine -receptor bearing cells and use thereof for treating disease
US9803189B2 (en) 2006-08-23 2017-10-31 Stc.Unm Virus-like platform for rapid vaccine discovery
WO2008073856A2 (en) 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US20080279764A1 (en) 2007-03-09 2008-11-13 Anthony Manganaro Method and composition for treating cancer
US9993437B2 (en) 2007-12-06 2018-06-12 The Regents Of The University Of California Mesoporous silica nanoparticles for biomedical applications
WO2009091531A2 (en) 2008-01-16 2009-07-23 The General Hospital Corporation Uniform-sized, multi-drug carrying and photosensitive liposomes for advance drug delivery
JP5539962B2 (ja) 2008-04-25 2014-07-02 ノースウェスタン、ユニバーシティ コレステロールを隔離するのに適したナノ構造体
CN101658533A (zh) 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送
WO2010048572A1 (en) 2008-10-23 2010-04-29 Cornell University A novel anti-viral method
US20110230372A1 (en) 2008-11-14 2011-09-22 Stc Unm Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and outcome prediction in pediatric b-precursor acute lymphoblastic leukemia
WO2010078569A2 (en) 2009-01-05 2010-07-08 Stc.Unm Porous nanoparticle supported lipid bilayer nanostructures
US8992984B1 (en) 2009-10-21 2015-03-31 Stc.Unm Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
US20130017210A1 (en) 2010-03-17 2013-01-17 Stc.Unm Display of antibody fragments on virus-like particles of rna bacteriophages
US20110300186A1 (en) 2010-04-14 2011-12-08 Battelle Memorial Institute Functionalized Nano- and Micro-materials for Medical Therapies
CN103687590A (zh) 2011-04-28 2014-03-26 Stc·Unm公司 用于靶向给药的多孔纳米颗粒支撑脂双层(原始细胞)及其使用方法
WO2013012891A1 (en) 2011-07-19 2013-01-24 Stc. Unm Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers
US20150272885A1 (en) 2011-10-14 2015-10-01 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
WO2013103614A1 (en) 2011-12-30 2013-07-11 Stc.Unm Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all)
EP2981611A4 (en) 2013-04-02 2016-11-16 Stc Unm ANTIBIOTICUM PROTOCOLS AND PHARMACEUTICAL FORMULATIONS AND TREATMENT METHODS THEREWITH
WO2014165617A1 (en) 2013-04-02 2014-10-09 Stc.Unm Mesoporous alum nanoparticles as universal platform for antigen adsorption, presentation, and delivery
WO2015042279A1 (en) 2013-09-18 2015-03-26 Stc. Unm Torroidal mesoporous silica nanoparticles (tmsnps) and related protocells

Similar Documents

Publication Publication Date Title
He et al. Exosomal targeting and its potential clinical application
US8992984B1 (en) Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
Dou et al. Aptamer–drug conjugate: Targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity
Auguste et al. Triggered release of siRNA from poly (ethylene glycol)-protected, pH-dependent liposomes
Roerig et al. Standardization approaches for extracellular vesicle loading with oligonucleotides and biologics
US10022327B2 (en) Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
Wang et al. Endosomal escape kinetics of mesoporous silica-based system for efficient siRNA delivery
Boado Blood–brain barrier transport of non-viral gene and RNAi therapeutics
US20170232115A1 (en) Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
Meissner et al. Novel antisense therapeutics delivery systems: In vitro and in vivo studies of liposomes targeted with anti-CD20 antibody
JP2014532071A5 (enExample)
US20200197536A1 (en) Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators
Li et al. Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system
WO2014058179A2 (ko) 저밀도 지단백질 유사 나노입자 및 이를 포함하는 간 표적 진단 및 치료용 조성물
R. Beech et al. Mechanisms for targeted delivery of nanoparticles in cancer
US9211346B2 (en) Carrier-linked magnetic nanoparticle drug delivery composition and method of use
Khera et al. Highlighting the potential role of exosomes as the targeted nanotherapeutic carrier in metastatic breast cancer
Herringson et al. Increasing the antitumor efficacy of doxorubicin-loaded liposomes with peptides anchored via a chelator lipid
WO2021234699A1 (en) MAdCAM-1 POLYPEPTIDES AND USES THEREOF
US20230357353A1 (en) MAdCAM-1 POLYPEPTIDES AND USES THEREOF
Yue et al. Methods for Analysis of Extracellular Vesicle Functions
Alfagih Liposomes for Targeting RNA Interference-Based Therapy in Inflammatory Bowel Diseases
Niculescu et al. New applications of lipid and polymer-based nanoparticles for nucleic acids delivery. Pharmaceutics. 2021; 13: 2053
Yang et al. Nanotechnology in gene delivery: pharmacokinetic and pharmacodynamic perspectives
Nargis Development of an innovative drug delivery system targeted to adipose vessel utilizing novel nucleic acid aptamer for control of obesity