CN103687590A - 用于靶向给药的多孔纳米颗粒支撑脂双层(原始细胞)及其使用方法 - Google Patents
用于靶向给药的多孔纳米颗粒支撑脂双层(原始细胞)及其使用方法 Download PDFInfo
- Publication number
- CN103687590A CN103687590A CN201280031496.8A CN201280031496A CN103687590A CN 103687590 A CN103687590 A CN 103687590A CN 201280031496 A CN201280031496 A CN 201280031496A CN 103687590 A CN103687590 A CN 103687590A
- Authority
- CN
- China
- Prior art keywords
- cell
- protocell
- inhibitors
- cancer
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161479847P | 2011-04-28 | 2011-04-28 | |
| US61/479,847 | 2011-04-28 | ||
| PCT/US2012/035529 WO2012149376A2 (en) | 2011-04-28 | 2012-04-27 | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103687590A true CN103687590A (zh) | 2014-03-26 |
Family
ID=47073093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280031496.8A Pending CN103687590A (zh) | 2011-04-28 | 2012-04-27 | 用于靶向给药的多孔纳米颗粒支撑脂双层(原始细胞)及其使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9579283B2 (enExample) |
| EP (1) | EP2701686A4 (enExample) |
| JP (1) | JP2014512409A (enExample) |
| CN (1) | CN103687590A (enExample) |
| AU (1) | AU2012249474A1 (enExample) |
| CA (1) | CA2834365A1 (enExample) |
| WO (1) | WO2012149376A2 (enExample) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104023711A (zh) * | 2011-10-14 | 2014-09-03 | Stc.Unm公司 | 用于靶向递送(包括负载物的透皮递送)的多孔纳米颗粒支撑的脂质双层(原始细胞)及其方法 |
| CN104667290A (zh) * | 2014-10-25 | 2015-06-03 | 中国科学技术大学 | 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用 |
| CN105456198A (zh) * | 2015-12-25 | 2016-04-06 | 正大天晴药业集团股份有限公司 | 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法 |
| CN107920964A (zh) * | 2015-07-09 | 2018-04-17 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| CN108367076A (zh) * | 2015-10-22 | 2018-08-03 | 德尔科技有限公司 | 水凝胶复合材料药性持久制剂 |
| CN108938595A (zh) * | 2018-07-15 | 2018-12-07 | 河南工业大学 | 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法 |
| CN110120249A (zh) * | 2019-05-23 | 2019-08-13 | 复旦大学 | 通过靶向调控动力学路径构造靶向构造目标结构的方法 |
| CN111991558A (zh) * | 2020-08-28 | 2020-11-27 | 安徽贝克生物制药有限公司 | 一种抗逆转录病毒药物组合物及其制备方法 |
| CN112480212A (zh) * | 2020-12-17 | 2021-03-12 | 中国药科大学 | 靶向肝细胞生长因子的高亲和肽及其应用 |
| CN113616618A (zh) * | 2017-09-22 | 2021-11-09 | 杭州景杰生物科技有限公司 | 利用微混合和卡培他滨两亲性特性的卡培他滨的聚合物-脂质混杂纳米颗粒 |
| CN114949250A (zh) * | 2016-04-14 | 2022-08-30 | 斯宾纳克生物科学公司 | 用于递送治疗剂的组合物、药物组合物、制备方法以及用途 |
| US20230321032A1 (en) * | 2022-04-06 | 2023-10-12 | University Of Kentucky Research Foundation | Functionalized mesoporous silica nanoparticles for treatment of periodontal disease |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5660561B2 (ja) * | 2006-09-28 | 2015-01-28 | ハダシット メディカルリサーチサービセス アンド ディベロップメント リミテッド | ジョイント部の潤滑に関するグリセロリン脂質の使用 |
| US8992984B1 (en) | 2009-10-21 | 2015-03-31 | Stc.Unm | Protocells and their use for targeted delivery of multicomponent cargos to cancer cells |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| CN103429606A (zh) | 2010-10-01 | 2013-12-04 | 现代治疗公司 | 设计核酸及其使用方法 |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| JP2014512409A (ja) * | 2011-04-28 | 2014-05-22 | エスティーシー. ユーエヌエム | 標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその使用方法 |
| EP3412282B1 (en) * | 2011-06-02 | 2024-10-09 | The Regents of the University of California | Membrane encapsulated nanoparticles and method of use |
| AU2012284147A1 (en) | 2011-07-19 | 2014-02-27 | Stc. Unm | Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2013103614A1 (en) * | 2011-12-30 | 2013-07-11 | Stc.Unm | Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all) |
| AU2013243954A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9273305B1 (en) | 2012-04-25 | 2016-03-01 | Sandia Corporation | Cell-based composite materials with programmed structures and functions |
| CN113842362A (zh) | 2012-11-14 | 2021-12-28 | 格雷斯公司 | 含有生物活性材料与无序无机氧化物的组合物 |
| DK2922554T3 (en) | 2012-11-26 | 2022-05-23 | Modernatx Inc | Terminalt modificeret rna |
| EP2943565B1 (en) | 2013-01-14 | 2018-03-28 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
| EP2964201B1 (en) * | 2013-03-05 | 2024-02-14 | The Regents of the University of California | Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents |
| EP2968191B1 (en) | 2013-03-14 | 2021-06-16 | Abraxis BioScience, LLC | Methods of treating bladder cancer |
| US20140271815A1 (en) * | 2013-03-15 | 2014-09-18 | Aryo Sorayya | Heat-and freeze-stable vaccines and methods of making and using same |
| US9603799B2 (en) | 2013-03-15 | 2017-03-28 | Htd Biosystems Inc. | Liposomal vaccine adjuvants and methods of making and using same |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EP2981249A4 (en) * | 2013-04-02 | 2016-11-23 | Stc Unm | MESOPOROUS ALAN NANOPARTICLES AS A UNIVERSAL PLATFORM FOR ADSORPTION, PRESENTATION, AND ADMINISTRATION OF ANTIGENS |
| CN103989631A (zh) * | 2013-04-15 | 2014-08-20 | 中国人民解放军第二军医大学 | 萝卜硫素制剂及其制备方法和应用 |
| CN103990130A (zh) * | 2013-06-24 | 2014-08-20 | 中国人民解放军第二军医大学 | 介孔二氧化硅纳米制剂及其制备方法和应用 |
| US10272137B2 (en) | 2013-06-27 | 2019-04-30 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomaker-induced muscle cell fusion |
| WO2015042268A1 (en) * | 2013-09-18 | 2015-03-26 | Stc.Unm | Core and surface modification of mesoporous silica nanoparticles to achieve cell specific targeting in vivo |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| BR112016007255A2 (pt) | 2013-10-03 | 2017-09-12 | Moderna Therapeutics Inc | polinucleotídeos que codificam receptor de lipoproteína de baixa densidade |
| PT3981437T (pt) | 2014-04-23 | 2025-01-15 | Modernatx Inc | Vacinas de ácidos nucleicos |
| CN115607688A (zh) | 2014-07-22 | 2023-01-17 | 雷莫内克斯生物制药有限公司 | 用于递送生物活性物质或蛋白质的组合物及其用途 |
| WO2016054225A1 (en) * | 2014-09-30 | 2016-04-07 | Stc.Unm | Plasmid delivery in the treatment of cancer and other disease states |
| WO2016205515A1 (en) * | 2015-06-17 | 2016-12-22 | The Curators Of The University Of Missouri | GOLD NANOROD BASED DIAGNOSTIC AGENT FOR DETECTION AND QUANTIFICATION OF c-MET (HGF) RECEPTORS |
| LU92783B1 (en) * | 2015-07-22 | 2017-01-31 | Luxembourg Inst Of Science And Tech (List) | Highly aminated self-assembling fuctionalized Mesoporous Silicia Nanoparticles and methods of synthesis |
| LU92784B1 (en) * | 2015-07-22 | 2017-01-31 | Luxembourg Inst Of Science And Tech (List) | Negatively charged self-assembling supported lipid bilayer on mesoporous silica nanoparticles, method of synthesis and use as a nanovector |
| EP3328394A4 (en) | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | CONCATEMEE peptide epitope RNAs |
| JP2017038539A (ja) * | 2015-08-18 | 2017-02-23 | 日本電信電話株式会社 | 脂質二分子膜基板 |
| US20190262469A1 (en) * | 2015-09-04 | 2019-08-29 | C. Jeffrey Brinker | Protocells to treat microbial infection and for synergistic delivery |
| US20180344641A1 (en) * | 2015-09-04 | 2018-12-06 | C. Jeffrey Brinker | Mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles for biomedical applications |
| SMT202200178T1 (it) | 2015-09-17 | 2022-05-12 | Modernatx Inc | Composti e composizioni per il rilascio intracellulare di agenti terapeutici |
| US10016422B2 (en) * | 2015-09-30 | 2018-07-10 | Oregon State University | Nanocarrier drug delivery platform |
| PL3394030T3 (pl) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Związki i kompozycje do wewnątrzkomórkowego dostarczania środków |
| WO2017117275A1 (en) * | 2015-12-31 | 2017-07-06 | City Of Hope | Silica nanoparticle with platinum anti-cancer agent |
| WO2017120504A1 (en) * | 2016-01-08 | 2017-07-13 | Durfee Paul N | Osteotropic nanoparticles for prevention or treatment of bone metastases |
| EP3399966B1 (en) | 2016-01-08 | 2023-03-29 | The Regents of the University of California | Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery |
| EP3429630A1 (en) * | 2016-03-16 | 2019-01-23 | Merrimack Pharmaceuticals, Inc. | Nanoliposomal targeting of ephrin receptor a2 (epha2) and related diagnosticss |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| US10663450B2 (en) * | 2016-06-15 | 2020-05-26 | The University Of Chicago | Amorphous, porous silicon materials and related methods |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| EP3558327A4 (en) * | 2016-12-21 | 2020-12-09 | Fred Hutchinson Cancer Research Center | SCAFFOLDING TO TREAT SOLID TUMOR CELLS AND EXHAUST VARIANTS |
| US10874768B2 (en) * | 2017-01-20 | 2020-12-29 | Covidien Lp | Drug eluting medical device |
| MX388358B (es) | 2017-02-06 | 2025-03-19 | Lemonex Inc | Portador de sustancia fisiologicamente activa. |
| US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
| AU2018234814B2 (en) | 2017-03-15 | 2022-06-30 | Modernatx, Inc. | Crystal forms of amino lipids |
| AU2018234828A1 (en) | 2017-03-15 | 2019-09-19 | Modernatx, Inc. | Lipid nanoparticle formulation |
| LT3596041T (lt) | 2017-03-15 | 2023-01-25 | Modernatx, Inc. | Terapinių medžiagų, skirtų intraląsteliniam tiekimui, junginys ir sudėtys |
| WO2018187287A1 (en) * | 2017-04-03 | 2018-10-11 | Charles Jeffrey Brinker | Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators |
| MA48047A (fr) | 2017-04-05 | 2020-02-12 | Modernatx Inc | Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée |
| BR112019023323A2 (pt) * | 2017-05-08 | 2020-07-21 | Flagship Pioneering Innovations V, Inc. | composições para facilitar a fusão de membrana e usos das mesmas |
| EP3638678B1 (en) | 2017-06-14 | 2025-12-03 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of agents |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| US11007516B1 (en) | 2017-06-19 | 2021-05-18 | National Technology & Engineering Solutions Of Sandia, Llc | Tunable metal-organic framework compositions and methods thereof |
| CN110996911B (zh) * | 2017-06-26 | 2023-01-17 | 福多兹制药公司 | 阿瑞匹坦的纳米微脂囊配制品及其方法和应用 |
| AU2018308332B2 (en) * | 2017-07-25 | 2021-11-18 | Lemonex Inc. | Composition for delivering physiologically active ingredients into blood vessel |
| CN111315359A (zh) | 2017-08-31 | 2020-06-19 | 摩登纳特斯有限公司 | 制备脂质纳米颗粒的方法 |
| KR102152348B1 (ko) | 2017-09-05 | 2020-09-08 | 주식회사 레모넥스 | 세포 운명 조절용 조성물 |
| US10933027B1 (en) | 2017-09-25 | 2021-03-02 | National Technology & Engineering Solutions Of Sandia, Llc | Expanded pore particles and delivery methods thereof |
| EP3735250A4 (en) | 2018-01-01 | 2022-04-13 | The Regents Of The University Of California | INDUSTRIAL-SCALE SYNTHESIS OF SILICASOMES-TYPE NANOSUPPORTS |
| US20200405650A1 (en) * | 2018-02-28 | 2020-12-31 | Achraf Noureddine | Starry mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles |
| CA3099267A1 (en) | 2018-05-08 | 2019-11-14 | Yale University | Protein capture membrane and method of use thereof |
| US11045554B1 (en) * | 2018-06-22 | 2021-06-29 | National Technology & Engineering Solutions Of Sandia, Llc | Lipid-coated particles for treating viral infections |
| KR20210043574A (ko) | 2018-07-09 | 2021-04-21 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 푸소좀 조성물 및 이의 용도 |
| CA3113436A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| WO2020068798A1 (en) | 2018-09-24 | 2020-04-02 | Guo Jimin | Living mammalian cells modified with functional modular nanoparticles |
| CN113631718A (zh) | 2018-11-14 | 2021-11-09 | 旗舰先锋创新V股份有限公司 | 用于特定隔室货物递送的组合物和方法 |
| WO2020102485A1 (en) * | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for hematopoietic stem cell delivery |
| US12208164B2 (en) | 2019-02-28 | 2025-01-28 | Unm Rainforest Innovations | Modular metal-organic polyhedra superassembly compositions |
| WO2020190750A1 (en) | 2019-03-15 | 2020-09-24 | Modernatx, Inc. | Hiv rna vaccines |
| BR112022004759A2 (pt) | 2019-09-19 | 2022-06-21 | Modernatx Inc | Composições e compostos lipídicos com cauda ramificada para entrega intracelular de agentes terapêuticos |
| CN111529505B (zh) * | 2020-03-25 | 2023-04-11 | 西安组织工程与再生医学研究所 | 功能性嵌合凋亡小体及其制备方法和应用 |
| CN111529504B (zh) * | 2020-03-25 | 2023-01-10 | 西安组织工程与再生医学研究所 | 功能性嵌合凋亡小体及其制备方法和应用 |
| US11433121B1 (en) | 2020-04-03 | 2022-09-06 | National Technology & Engineering Solutions Of Sandia, Llc | Lipid composition for the delivery of therapeutic cargos |
| CN111588704B (zh) * | 2020-07-01 | 2023-04-11 | 西安组织工程与再生医学研究所 | 靶向响应性释放系统及其制备方法和应用 |
| CN112168977A (zh) * | 2020-10-27 | 2021-01-05 | 西南大学 | 转铁蛋白修饰的二氧化硅荷载白藜芦醇及制备方法和应用 |
| CA3216353A1 (en) | 2021-04-08 | 2022-10-13 | Sana Biotechnology, Inc. | Cd8-specific antibody constructs and compositions thereof |
| US12194458B2 (en) * | 2022-08-16 | 2025-01-14 | Nicole Shamayev | Device and method of portable drug testing |
| US12098200B1 (en) | 2022-10-12 | 2024-09-24 | National Technology & Engineering Solutions Of Sandia, Llc | Brain-targeting single domain antibodies and purification methods |
| WO2024182425A1 (en) * | 2023-02-27 | 2024-09-06 | Noureddine Achraf | Compositions and methods for treating metabolic diseases/disorders |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658533A (zh) * | 2008-08-29 | 2010-03-03 | 首都医科大学宣武医院 | 抗肿瘤药物的干细胞递送 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5277913A (en) | 1991-09-09 | 1994-01-11 | Thompson David H | Liposomal delivery system with photoactivatable triggered release |
| US5820879A (en) | 1993-02-12 | 1998-10-13 | Access Pharmaceuticals, Inc. | Method of delivering a lipid-coated condensed-phase microparticle composition |
| EP0692972B2 (en) | 1993-04-02 | 2012-03-21 | AntiCancer, Inc. | Method for delivering beneficial compositions to hair follicles |
| US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| ATE419273T1 (de) * | 1998-11-13 | 2009-01-15 | Cyclacel Ltd | Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3 |
| CA2371728C (en) | 1999-06-11 | 2009-06-02 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
| GB0104259D0 (en) * | 2001-02-21 | 2001-04-11 | Smithkline Beecham Biolog | Novel compounds |
| WO2003016040A1 (en) | 2001-04-16 | 2003-02-27 | The Regents Of The University Of California | Membrane mimetic architectures on nanoporous materials |
| IL162183A0 (en) | 2001-12-21 | 2005-11-20 | Celator Technologies Inc | Polymer-lipid delivery vehicles and methods for the preparation thereof |
| US20040005352A1 (en) | 2002-04-16 | 2004-01-08 | Lopez Gabriel P. | Biologically functionalized porous microspheres |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| US7563451B2 (en) | 2003-07-22 | 2009-07-21 | Iowa State University Research Foundation, Inc. | Capped mesoporous silicates |
| BRPI0607321A2 (pt) | 2005-02-14 | 2009-09-01 | Australian Nuclear Science Tech Org | nanopartìculas em camadas |
| US8465983B1 (en) | 2005-08-19 | 2013-06-18 | Gabriel P. Lopez | Detection and delivery systems utilizing supported lipid bilayers |
| BRPI0618488A2 (pt) | 2005-11-10 | 2011-08-30 | Receptor Biologix Inc | proteìnas de fusão de ìntron de fator de crescimento de hepatócito |
| US20080160313A1 (en) * | 2006-04-26 | 2008-07-03 | Gabriel Lopez | Lipid bilayers on nanotextured solid surfaces |
| WO2007140618A1 (en) | 2006-06-09 | 2007-12-13 | Protox Therapeutics Incorporated | Modified protein toxins targeting cytokine -receptor bearing cells and use thereof for treating disease |
| US9803189B2 (en) | 2006-08-23 | 2017-10-31 | Stc.Unm | Virus-like platform for rapid vaccine discovery |
| EP2099496A2 (en) | 2006-12-08 | 2009-09-16 | Massachusetts Institute of Technology | Delivery of nanoparticles and/or agents to cells |
| US20080279764A1 (en) | 2007-03-09 | 2008-11-13 | Anthony Manganaro | Method and composition for treating cancer |
| US9993437B2 (en) | 2007-12-06 | 2018-06-12 | The Regents Of The University Of California | Mesoporous silica nanoparticles for biomedical applications |
| WO2009091531A2 (en) | 2008-01-16 | 2009-07-23 | The General Hospital Corporation | Uniform-sized, multi-drug carrying and photosensitive liposomes for advance drug delivery |
| CN102036652B (zh) | 2008-04-25 | 2016-04-13 | 西北大学 | 适于螯合胆甾醇的纳米结构 |
| WO2010048572A1 (en) | 2008-10-23 | 2010-04-29 | Cornell University | A novel anti-viral method |
| US20110230372A1 (en) | 2008-11-14 | 2011-09-22 | Stc Unm | Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and outcome prediction in pediatric b-precursor acute lymphoblastic leukemia |
| WO2010078569A2 (en) | 2009-01-05 | 2010-07-08 | Stc.Unm | Porous nanoparticle supported lipid bilayer nanostructures |
| US8992984B1 (en) | 2009-10-21 | 2015-03-31 | Stc.Unm | Protocells and their use for targeted delivery of multicomponent cargos to cancer cells |
| US20130017210A1 (en) | 2010-03-17 | 2013-01-17 | Stc.Unm | Display of antibody fragments on virus-like particles of rna bacteriophages |
| US20110300186A1 (en) | 2010-04-14 | 2011-12-08 | Battelle Memorial Institute | Functionalized Nano- and Micro-materials for Medical Therapies |
| JP2014512409A (ja) | 2011-04-28 | 2014-05-22 | エスティーシー. ユーエヌエム | 標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその使用方法 |
| AU2012284147A1 (en) | 2011-07-19 | 2014-02-27 | Stc. Unm | Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers |
| WO2013056132A2 (en) | 2011-10-14 | 2013-04-18 | Stc.Unm | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof |
| WO2013103614A1 (en) | 2011-12-30 | 2013-07-11 | Stc.Unm | Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all) |
| EP2981249A4 (en) | 2013-04-02 | 2016-11-23 | Stc Unm | MESOPOROUS ALAN NANOPARTICLES AS A UNIVERSAL PLATFORM FOR ADSORPTION, PRESENTATION, AND ADMINISTRATION OF ANTIGENS |
| WO2014165608A1 (en) | 2013-04-02 | 2014-10-09 | Stc. Unm | Antibiotic protocells and related pharmaceutical formulations and methods of treatment |
| US9855217B2 (en) | 2013-09-18 | 2018-01-02 | Stc. Unm | Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells |
-
2012
- 2012-04-27 JP JP2014508125A patent/JP2014512409A/ja active Pending
- 2012-04-27 AU AU2012249474A patent/AU2012249474A1/en not_active Abandoned
- 2012-04-27 EP EP12776480.1A patent/EP2701686A4/en not_active Withdrawn
- 2012-04-27 WO PCT/US2012/035529 patent/WO2012149376A2/en not_active Ceased
- 2012-04-27 CA CA2834365A patent/CA2834365A1/en not_active Abandoned
- 2012-04-27 CN CN201280031496.8A patent/CN103687590A/zh active Pending
- 2012-04-27 US US14/113,371 patent/US9579283B2/en active Active
-
2015
- 2015-12-16 US US14/970,998 patent/US10022327B2/en not_active Expired - Fee Related
-
2018
- 2018-07-02 US US16/025,557 patent/US20190091150A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658533A (zh) * | 2008-08-29 | 2010-03-03 | 首都医科大学宣武医院 | 抗肿瘤药物的干细胞递送 |
Non-Patent Citations (2)
| Title |
|---|
| CARLEE E. ASHLEY ET.AL: "The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers", 《NATURE MATERIALS》, vol. 10, 17 April 2011 (2011-04-17), pages 389 - 397, XP055132474, DOI: 10.1038/nmat2992 * |
| JUEWEN LIU ET.AL: "Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles", 《J AM CHEM SOC》, vol. 131, no. 4, 4 February 2009 (2009-02-04), pages 1354 - 1355, XP055029872, DOI: 10.1021/ja808018y * |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104023711A (zh) * | 2011-10-14 | 2014-09-03 | Stc.Unm公司 | 用于靶向递送(包括负载物的透皮递送)的多孔纳米颗粒支撑的脂质双层(原始细胞)及其方法 |
| CN104667290A (zh) * | 2014-10-25 | 2015-06-03 | 中国科学技术大学 | 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用 |
| CN107920964A (zh) * | 2015-07-09 | 2018-04-17 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| CN114533898B (zh) * | 2015-07-09 | 2025-07-01 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| US11406597B2 (en) | 2015-07-09 | 2022-08-09 | The Regents Of The University Of California | Fusogenic liposome-coated porous silicon nanoparticles |
| CN114533898A (zh) * | 2015-07-09 | 2022-05-27 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| CN107920964B (zh) * | 2015-07-09 | 2022-02-25 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| CN108367076A (zh) * | 2015-10-22 | 2018-08-03 | 德尔科技有限公司 | 水凝胶复合材料药性持久制剂 |
| CN108367076B (zh) * | 2015-10-22 | 2021-08-31 | 德尔科技有限公司 | 水凝胶复合材料药性持久制剂 |
| CN105456198A (zh) * | 2015-12-25 | 2016-04-06 | 正大天晴药业集团股份有限公司 | 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法 |
| CN105456198B (zh) * | 2015-12-25 | 2017-04-26 | 正大天晴药业集团股份有限公司 | 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法 |
| CN114949250A (zh) * | 2016-04-14 | 2022-08-30 | 斯宾纳克生物科学公司 | 用于递送治疗剂的组合物、药物组合物、制备方法以及用途 |
| CN113616618A (zh) * | 2017-09-22 | 2021-11-09 | 杭州景杰生物科技有限公司 | 利用微混合和卡培他滨两亲性特性的卡培他滨的聚合物-脂质混杂纳米颗粒 |
| CN108938595B (zh) * | 2018-07-15 | 2021-09-14 | 河南工业大学 | 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法 |
| CN108938595A (zh) * | 2018-07-15 | 2018-12-07 | 河南工业大学 | 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法 |
| CN110120249A (zh) * | 2019-05-23 | 2019-08-13 | 复旦大学 | 通过靶向调控动力学路径构造靶向构造目标结构的方法 |
| CN111991558A (zh) * | 2020-08-28 | 2020-11-27 | 安徽贝克生物制药有限公司 | 一种抗逆转录病毒药物组合物及其制备方法 |
| CN112480212A (zh) * | 2020-12-17 | 2021-03-12 | 中国药科大学 | 靶向肝细胞生长因子的高亲和肽及其应用 |
| US20230321032A1 (en) * | 2022-04-06 | 2023-10-12 | University Of Kentucky Research Foundation | Functionalized mesoporous silica nanoparticles for treatment of periodontal disease |
Also Published As
| Publication number | Publication date |
|---|---|
| US10022327B2 (en) | 2018-07-17 |
| EP2701686A2 (en) | 2014-03-05 |
| US20140079774A1 (en) | 2014-03-20 |
| US20190091150A1 (en) | 2019-03-28 |
| US20160106671A1 (en) | 2016-04-21 |
| EP2701686A4 (en) | 2014-11-05 |
| CA2834365A1 (en) | 2012-11-01 |
| WO2012149376A3 (en) | 2013-01-17 |
| US9579283B2 (en) | 2017-02-28 |
| AU2012249474A1 (en) | 2013-11-07 |
| WO2012149376A2 (en) | 2012-11-01 |
| JP2014512409A (ja) | 2014-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103687590A (zh) | 用于靶向给药的多孔纳米颗粒支撑脂双层(原始细胞)及其使用方法 | |
| US20150272885A1 (en) | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof | |
| Pearce et al. | Peptide targeted lipid nanoparticles for anticancer drug delivery | |
| US20200197536A1 (en) | Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators | |
| US20180110831A1 (en) | Cd 47 containing porous nanoparticle supported lipid bilayers (protocells) field of the invention | |
| US20200375912A1 (en) | Liposomal coated nanoparticles for immunotherapy applications | |
| Houdaihed et al. | Dual-targeted delivery of nanoparticles encapsulating paclitaxel and everolimus: a novel strategy to overcome breast cancer receptor heterogeneity. | |
| CN108601746A (zh) | 用于运载物递送的具有脂质双层包衣的中孔二氧化硅纳米颗粒 | |
| JP2014532071A5 (enExample) | ||
| Salzano et al. | Transferrin-targeted nanoparticles containing zoledronic acid as a potential tool to inhibit glioblastoma growth | |
| Bian et al. | Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery | |
| JP5436650B1 (ja) | スーパーアパタイト超微細ナノ粒子 | |
| Li et al. | Nanoparticle binding to urokinase receptor on cancer cell surface triggers nanoparticle disintegration and cargo release | |
| Pan et al. | Nuclear-targeting TAT-PEG-Asp8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer | |
| Kim et al. | Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA | |
| EP3936121A1 (en) | Self assembling molecules for targeted drug delivery | |
| Yao et al. | Nucleic acid nanomaterials-based therapy for osteoarthritis: Progress and prospects | |
| US20230270882A1 (en) | Peptide-nanoparticle conjugates | |
| JP2003524624A (ja) | 治療薬の組織への送達を高める方法及び組成物 | |
| CN111557926A (zh) | 靶向性相变纳米药物系统及其制备方法与应用 | |
| Wang et al. | Optimization of landscape phage fusion protein-modified polymeric PEG-PE micelles for improved breast cancer cell targeting | |
| HK1190632A (en) | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same | |
| Wei et al. | Therapeutic effect of hepatocellular carcinoma-targeting liposome delivery system loaded with c [RGDyk] modified combretastatin A-4 and adriamycin: a pharmacodynamics study | |
| Duskey | The development and biological evaluation of octreotide containing peptides for receptor mediated non-viral gene delivery | |
| HK40065002A (en) | Self assembling molecules for targeted drug delivery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1190632 Country of ref document: HK |
|
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Brinch Jon Christian Inventor after: CARNES ERIC C Inventor after: ASHLEY CARLEE ERIN Inventor after: C - L - Weierman Inventor before: Brinch Jon Christian Inventor before: CARNES ERIC C Inventor before: ASHLEY CARLEE ERIN |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: JEFFREY C. BRINKER ERIC C. CARNES ASHLEY CARLEE ERIN TO: JEFFREY C. BRINKER ERIC C. CARNES ASHLEY CARLEE ERIN CHERYL L. WILLMAN |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140326 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1190632 Country of ref document: HK |