JP2014510132A - 抗菌剤として有用なイソオキサゾール誘導体 - Google Patents

抗菌剤として有用なイソオキサゾール誘導体 Download PDF

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Publication number
JP2014510132A
JP2014510132A JP2014503238A JP2014503238A JP2014510132A JP 2014510132 A JP2014510132 A JP 2014510132A JP 2014503238 A JP2014503238 A JP 2014503238A JP 2014503238 A JP2014503238 A JP 2014503238A JP 2014510132 A JP2014510132 A JP 2014510132A
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JP
Japan
Prior art keywords
methyl
hydroxy
methylsulfonyl
alkyl
butanamide
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JP2014503238A
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Japanese (ja)
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JP2014510132A5 (enExample
Inventor
エー． アブラミテ ジョセフ
エフ． ブラウン マシュー
マイケル チェン ジンシャン
メルニック マイケル
アイ． モンゴメリ− ジャスティン
レイリー ウサ
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ファイザー・インク
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Publication of JP2014510132A publication Critical patent/JP2014510132A/ja
Publication of JP2014510132A5 publication Critical patent/JP2014510132A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014503238A 2011-04-08 2012-03-23 抗菌剤として有用なイソオキサゾール誘導体 Pending JP2014510132A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161473540P 2011-04-08 2011-04-08
US61/473,540 2011-04-08
PCT/IB2012/051406 WO2012137094A1 (en) 2011-04-08 2012-03-23 Isoxazole derivatives useful as antibacterial agents

Publications (2)

Publication Number Publication Date
JP2014510132A true JP2014510132A (ja) 2014-04-24
JP2014510132A5 JP2014510132A5 (enExample) 2015-05-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014503238A Pending JP2014510132A (ja) 2011-04-08 2012-03-23 抗菌剤として有用なイソオキサゾール誘導体

Country Status (14)

Country Link
US (1) US8748466B2 (enExample)
EP (1) EP2694488B1 (enExample)
JP (1) JP2014510132A (enExample)
KR (1) KR20130140868A (enExample)
CN (1) CN103717582B (enExample)
AU (1) AU2012238374B2 (enExample)
CA (1) CA2830920C (enExample)
DK (1) DK2694488T3 (enExample)
ES (1) ES2526687T3 (enExample)
IL (2) IL228799A (enExample)
MX (1) MX2013011526A (enExample)
SG (1) SG193367A1 (enExample)
WO (1) WO2012137094A1 (enExample)
ZA (1) ZA201306736B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019522645A (ja) * 2016-06-14 2019-08-15 ノバルティス アーゲー 抗菌剤としての（ｒ）−４（５−（シクロプロピルエチニル）イソオキサゾール−３−イル）−ｎ−ヒドロキシ−２−メチル−２−（メチルスルホニル）ブタンアミドの結晶形
JP2019534252A (ja) * 2016-09-28 2019-11-28 ドン−ア エスティ カンパニー リミテッド テトラヒドロピリジン誘導体および抗菌剤としてのその使用

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US8722686B2 (en) 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
JP5793766B2 (ja) 2009-12-16 2015-10-14 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
JP5620020B2 (ja) 2011-03-07 2014-11-05 ファイザー・インク 抗菌剤として有用なフルオロ−ピリジノン誘導体
CN103492368A (zh) * 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物
SG193367A1 (en) 2011-04-08 2013-10-30 Pfizer Isoxazole derivatives useful as antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
US9937156B2 (en) * 2013-10-16 2018-04-10 The Board Of Regents Of The University Of Texas System Modulation of MRTF-A activity in pathologic fibrosis and wound healing
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
US9637482B2 (en) 2014-04-22 2017-05-02 Novartis Ag Isoxazoline hydroxamic acid derivatives as LpxC inhibitors
ES2687040T3 (es) 2014-05-16 2018-10-23 Idorsia Pharmaceuticals Ltd Derivados antibacterianos de quinazolin–4(3H)–ona
CA2963875A1 (en) 2014-11-19 2016-05-26 Actelion Pharmaceuticals Ltd Antibacterial benzothiazole derivatives
CU24443B1 (es) * 2014-12-16 2019-10-04 Novartis Ag COMPUESTOS DE ISOXAZOL DE ÁCIDO HIDROXÁMICO COMO INHIBIDORES DE LpxC
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
US10590498B2 (en) * 2016-05-17 2020-03-17 Lawrence Livermore National Security, Llc Compounds for reactivation of acetylcholinesterase and related compositions methods and systems
DE102016113269A1 (de) 2016-07-19 2018-01-25 Osram Opto Semiconductors Gmbh Leuchtvorrichtung für ein mobiles endgerät
TWI604678B (zh) * 2016-09-07 2017-11-01 國立暨南國際大學 Radio transmission system
US11186548B2 (en) 2017-11-23 2021-11-30 Lawrence Livermore National Security, Llc Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them
US20220002279A1 (en) * 2018-11-21 2022-01-06 Taisho Pharmaceutical Co., Ltd. Novel imidazole derivative
CN111944719B (zh) * 2020-08-14 2022-04-29 暨南大学 一株二恶烷降解菌is20及其制备方法和应用

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EP1437349A1 (en) * 2001-07-20 2004-07-14 Laboratorios S.A.L.V.A.T., S.A. Substituted isoxazoles and the use thereof as antibiotics
WO2010032147A2 (en) * 2008-09-19 2010-03-25 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents

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JP5227304B2 (ja) 2007-02-28 2013-07-03 大正製薬株式会社 新規なヒドロキサム酸誘導体
WO2008115262A2 (en) 2007-03-20 2008-09-25 Curis, Inc. Hsp90 inhibitors containing a zinc binding moiety
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JP5620020B2 (ja) 2011-03-07 2014-11-05 ファイザー・インク 抗菌剤として有用なフルオロ−ピリジノン誘導体
CN103492368A (zh) 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物
SG193367A1 (en) 2011-04-08 2013-10-30 Pfizer Isoxazole derivatives useful as antibacterial agents

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EP1437349A1 (en) * 2001-07-20 2004-07-14 Laboratorios S.A.L.V.A.T., S.A. Substituted isoxazoles and the use thereof as antibiotics
WO2010032147A2 (en) * 2008-09-19 2010-03-25 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019522645A (ja) * 2016-06-14 2019-08-15 ノバルティス アーゲー 抗菌剤としての（ｒ）−４（５−（シクロプロピルエチニル）イソオキサゾール−３−イル）−ｎ−ヒドロキシ−２−メチル−２−（メチルスルホニル）ブタンアミドの結晶形
JP2019534252A (ja) * 2016-09-28 2019-11-28 ドン−ア エスティ カンパニー リミテッド テトラヒドロピリジン誘導体および抗菌剤としてのその使用

Also Published As

Publication number Publication date
KR20130140868A (ko) 2013-12-24
WO2012137094A1 (en) 2012-10-11
IL240078A0 (en) 2015-08-31
CA2830920A1 (en) 2012-10-11
IL228799A0 (en) 2013-12-31
ES2526687T3 (es) 2015-01-14
IL228799A (en) 2015-08-31
EP2694488B1 (en) 2014-11-12
EP2694488A1 (en) 2014-02-12
US20140024690A1 (en) 2014-01-23
CA2830920C (en) 2015-07-14
AU2012238374B2 (en) 2015-04-02
CN103717582A (zh) 2014-04-09
US8748466B2 (en) 2014-06-10
AU2012238374A1 (en) 2013-09-26
DK2694488T3 (en) 2014-12-15
ZA201306736B (en) 2014-11-26
CN103717582B (zh) 2015-09-30
SG193367A1 (en) 2013-10-30
MX2013011526A (es) 2013-12-06

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