ZA201306736B - Isoxazole derivatives useful as antibacterial agents - Google Patents
Isoxazole derivatives useful as antibacterial agentsInfo
- Publication number
- ZA201306736B ZA201306736B ZA2013/06736A ZA201306736A ZA201306736B ZA 201306736 B ZA201306736 B ZA 201306736B ZA 2013/06736 A ZA2013/06736 A ZA 2013/06736A ZA 201306736 A ZA201306736 A ZA 201306736A ZA 201306736 B ZA201306736 B ZA 201306736B
- Authority
- ZA
- South Africa
- Prior art keywords
- antibacterial agents
- derivatives useful
- isoxazole derivatives
- isoxazole
- useful
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000002545 isoxazoles Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161473540P | 2011-04-08 | 2011-04-08 | |
| PCT/IB2012/051406 WO2012137094A1 (en) | 2011-04-08 | 2012-03-23 | Isoxazole derivatives useful as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201306736B true ZA201306736B (en) | 2014-11-26 |
Family
ID=45999906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2013/06736A ZA201306736B (en) | 2011-04-08 | 2013-09-09 | Isoxazole derivatives useful as antibacterial agents |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8748466B2 (enExample) |
| EP (1) | EP2694488B1 (enExample) |
| JP (1) | JP2014510132A (enExample) |
| KR (1) | KR20130140868A (enExample) |
| CN (1) | CN103717582B (enExample) |
| AU (1) | AU2012238374B2 (enExample) |
| CA (1) | CA2830920C (enExample) |
| DK (1) | DK2694488T3 (enExample) |
| ES (1) | ES2526687T3 (enExample) |
| IL (2) | IL228799A (enExample) |
| MX (1) | MX2013011526A (enExample) |
| SG (1) | SG193367A1 (enExample) |
| WO (1) | WO2012137094A1 (enExample) |
| ZA (1) | ZA201306736B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2334636A2 (en) | 2008-09-19 | 2011-06-22 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| PL2512474T3 (pl) | 2009-12-16 | 2015-03-31 | Pfizer | N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne |
| AP3336A (en) | 2011-03-07 | 2015-07-31 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| SG193458A1 (en) | 2011-04-08 | 2013-10-30 | Pfizer | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| CN103717582B (zh) | 2011-04-08 | 2015-09-30 | 辉瑞大药厂 | 用作抗菌剂的异*唑衍生物 |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| US9937156B2 (en) * | 2013-10-16 | 2018-04-10 | The Board Of Regents Of The University Of Texas System | Modulation of MRTF-A activity in pathologic fibrosis and wound healing |
| TR201807881T4 (tr) | 2013-12-19 | 2018-06-21 | Idorsia Pharmaceuticals Ltd | Antibakteriyel 1h-ındazol ve 1h-ındol türevleri. |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| CN106573924B (zh) | 2014-04-22 | 2019-06-25 | 诺华股份有限公司 | 作为LpxC抑制剂的异噁唑啉异羟肟酸衍生物 |
| JP2017515906A (ja) | 2014-05-16 | 2017-06-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性キナゾロン−４（３ｈ）−オン誘導体 |
| KR20170086079A (ko) | 2014-11-19 | 2017-07-25 | 액테리온 파마슈티칼 리미티드 | 항균성 벤조티아졸 유도체 |
| EA032138B1 (ru) * | 2014-12-16 | 2019-04-30 | Новартис Аг | СОЕДИНЕНИЯ ИЗОКСАЗОЛГИДРОКСАМИНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LpxC |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105848A1 (es) * | 2015-08-31 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados heterocíclicos antibacterianos |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| US10590498B2 (en) * | 2016-05-17 | 2020-03-17 | Lawrence Livermore National Security, Llc | Compounds for reactivation of acetylcholinesterase and related compositions methods and systems |
| CA3026356A1 (en) * | 2016-06-14 | 2017-12-21 | Novartis Ag | Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent |
| DE102016113269A1 (de) | 2016-07-19 | 2018-01-25 | Osram Opto Semiconductors Gmbh | Leuchtvorrichtung für ein mobiles endgerät |
| TWI604678B (zh) * | 2016-09-07 | 2017-11-01 | 國立暨南國際大學 | Radio transmission system |
| AU2017337946B2 (en) * | 2016-09-28 | 2020-05-07 | Dong-A St Co., Ltd. | Tetrahydropyridine derivatives and their use as antibacterial agents |
| US11186548B2 (en) | 2017-11-23 | 2021-11-30 | Lawrence Livermore National Security, Llc | Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them |
| MX2021005966A (es) * | 2018-11-21 | 2021-07-06 | Taisho Pharmaceutical Co Ltd | Nuevo derivado de imidazol. |
| CN111944719B (zh) * | 2020-08-14 | 2022-04-29 | 暨南大学 | 一株二恶烷降解菌is20及其制备方法和应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769461A (en) | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
| US5110831A (en) | 1990-11-30 | 1992-05-05 | Du Pont Merck Pharmaceutical Company | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors |
| EP1052984B1 (en) | 1998-02-07 | 2004-05-12 | Vernalis (Oxford) Ltd | Antibacterial agents |
| GB9925470D0 (en) | 1999-10-27 | 1999-12-29 | Smithkline Beecham Plc | Novel compounds |
| US20050119305A1 (en) | 2001-03-21 | 2005-06-02 | Masao Naka | Il-6 production inhibitors |
| ES2180456B1 (es) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| SG2012000667A (en) | 2003-01-08 | 2015-03-30 | Univ Washington | Antibacterial agents |
| GB0302431D0 (en) | 2003-01-30 | 2003-03-05 | Glaxo Group Ltd | Novel compounds |
| CN101115725A (zh) | 2004-12-10 | 2008-01-30 | 埃莫里大学 | 治疗病毒感染和异常细胞增殖的2’和3’-取代的环丁基核苷类似物 |
| WO2006118155A1 (ja) | 2005-04-27 | 2006-11-09 | Ishihara Sangyo Kaisha, Ltd. | ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤 |
| WO2006124897A2 (en) | 2005-05-13 | 2006-11-23 | Lexicon Genetics Incorporated | Methods and compositions for improving cognition |
| US8088804B2 (en) | 2005-12-15 | 2012-01-03 | Pfizer Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| ES2331930T3 (es) * | 2006-02-14 | 2010-01-20 | Pfizer Products Inc. | Oxazolidinonas con benzoxazinonas y benzoxazepinonas como agentes antibacterianos. |
| WO2008045671A1 (en) | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica, N.V. | Matrix metalloprotease inhibitors |
| CN101016270B (zh) * | 2006-12-30 | 2012-05-09 | 天津药物研究院 | 取代的哌嗪基苯基异噁唑啉衍生物及其用途 |
| WO2009008905A1 (en) | 2007-02-01 | 2009-01-15 | Panthera Biopharma, Llc. | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| WO2008105515A1 (ja) | 2007-02-28 | 2008-09-04 | Taisho Pharmaceutical Co., Ltd. | 新規なヒドロキサム酸誘導体 |
| US20080234297A1 (en) | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
| CA2732045A1 (en) | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
| JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| EP2334636A2 (en) | 2008-09-19 | 2011-06-22 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| PL2512474T3 (pl) | 2009-12-16 | 2015-03-31 | Pfizer | N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne |
| AP3336A (en) | 2011-03-07 | 2015-07-31 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| SG193458A1 (en) | 2011-04-08 | 2013-10-30 | Pfizer | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| CN103717582B (zh) | 2011-04-08 | 2015-09-30 | 辉瑞大药厂 | 用作抗菌剂的异*唑衍生物 |
-
2012
- 2012-03-23 CN CN201280016114.4A patent/CN103717582B/zh not_active Expired - Fee Related
- 2012-03-23 SG SG2013067616A patent/SG193367A1/en unknown
- 2012-03-23 KR KR1020137029552A patent/KR20130140868A/ko not_active Abandoned
- 2012-03-23 JP JP2014503238A patent/JP2014510132A/ja active Pending
- 2012-03-23 WO PCT/IB2012/051406 patent/WO2012137094A1/en not_active Ceased
- 2012-03-23 AU AU2012238374A patent/AU2012238374B2/en not_active Ceased
- 2012-03-23 CA CA2830920A patent/CA2830920C/en not_active Expired - Fee Related
- 2012-03-23 US US14/110,157 patent/US8748466B2/en not_active Expired - Fee Related
- 2012-03-23 MX MX2013011526A patent/MX2013011526A/es not_active Application Discontinuation
- 2012-03-23 ES ES12716624.7T patent/ES2526687T3/es active Active
- 2012-03-23 EP EP12716624.7A patent/EP2694488B1/en not_active Not-in-force
- 2012-03-23 DK DK12716624.7T patent/DK2694488T3/en active
-
2013
- 2013-09-09 ZA ZA2013/06736A patent/ZA201306736B/en unknown
- 2013-10-08 IL IL228799A patent/IL228799A/en not_active IP Right Cessation
-
2015
- 2015-07-21 IL IL240078A patent/IL240078A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL228799A0 (en) | 2013-12-31 |
| CN103717582A (zh) | 2014-04-09 |
| AU2012238374B2 (en) | 2015-04-02 |
| AU2012238374A1 (en) | 2013-09-26 |
| US20140024690A1 (en) | 2014-01-23 |
| WO2012137094A1 (en) | 2012-10-11 |
| CA2830920A1 (en) | 2012-10-11 |
| ES2526687T3 (es) | 2015-01-14 |
| IL240078A0 (en) | 2015-08-31 |
| JP2014510132A (ja) | 2014-04-24 |
| EP2694488A1 (en) | 2014-02-12 |
| KR20130140868A (ko) | 2013-12-24 |
| MX2013011526A (es) | 2013-12-06 |
| CA2830920C (en) | 2015-07-14 |
| SG193367A1 (en) | 2013-10-30 |
| DK2694488T3 (en) | 2014-12-15 |
| CN103717582B (zh) | 2015-09-30 |
| IL228799A (en) | 2015-08-31 |
| EP2694488B1 (en) | 2014-11-12 |
| US8748466B2 (en) | 2014-06-10 |
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