|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4828991A
(en)
|
1984-01-31 |
1989-05-09 |
Akzo N.V. |
Tumor specific monoclonal antibodies
|
|
US5369108A
(en)
|
1991-10-04 |
1994-11-29 |
Sloan-Kettering Institute For Cancer Research |
Potent inducers of terminal differentiation and methods of use thereof
|
|
US5502187A
(en)
|
1992-04-03 |
1996-03-26 |
The Upjohn Company |
Pharmaceutically active bicyclic-heterocyclic amines
|
|
US5497763A
(en)
|
1993-05-21 |
1996-03-12 |
Aradigm Corporation |
Disposable package for intrapulmonary delivery of aerosolized formulations
|
|
US5508269A
(en)
|
1994-10-19 |
1996-04-16 |
Pathogenesis Corporation |
Aminoglycoside formulation for aerosolization
|
|
US6777217B1
(en)
|
1996-03-26 |
2004-08-17 |
President And Fellows Of Harvard College |
Histone deacetylases, and uses related thereto
|
|
US6083922A
(en)
|
1996-04-02 |
2000-07-04 |
Pathogenesis, Corp. |
Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
|
|
US5767068A
(en)
|
1997-02-13 |
1998-06-16 |
Pathogenesis Corporation |
Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
|
|
US6608053B2
(en)
|
2000-04-27 |
2003-08-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Fused heteroaryl derivatives
|
|
AU5261001A
(en)
|
2000-04-27 |
2001-11-12 |
Imperial Cancer Research Technology Ltd |
Condensed heteroaryl derivatives
|
|
CA2476583C
(en)
|
2002-03-13 |
2011-07-05 |
Kristof Van Emelen |
Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
|
|
JP4648628B2
(ja)
|
2002-03-13 |
2011-03-09 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ヒストンデアセチラーゼの新規な阻害剤としてのカルボニルアミノ誘導体
|
|
WO2003076401A1
(en)
|
2002-03-13 |
2003-09-18 |
Janssen Pharmaceutica N.V. |
Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
|
|
ES2306859T3
(es)
|
2002-03-13 |
2008-11-16 |
Janssen Pharmaceutica Nv |
Derivados de sulfonil como nuevos inhibidores de histona deacetilasa.
|
|
WO2004017950A2
(en)
|
2002-08-22 |
2004-03-04 |
Piramed Limited |
Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents
|
|
CN101153042A
(zh)
|
2003-01-29 |
2008-04-02 |
武田药品工业株式会社 |
噻吩并嘧啶化合物及其用途
|
|
CA2561617A1
(en)
|
2004-04-05 |
2005-10-20 |
Aton Pharma, Inc. |
Histone deacetylase inhibitor prodrugs
|
|
WO2005117909A2
(en)
|
2004-04-23 |
2005-12-15 |
Exelixis, Inc. |
Kinase modulators and methods of use
|
|
WO2006040966A1
(ja)
|
2004-10-08 |
2006-04-20 |
Astellas Pharma Inc. |
芳香環縮合ピリミジン誘導体
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
NZ589276A
(en)
|
2005-02-03 |
2012-06-29 |
Topotarget Uk Ltd |
Combination therapies using hdac inhibitors and erlotinib (tarceva)
|
|
DK1885710T3
(en)
|
2005-05-18 |
2015-11-23 |
Janssen Pharmaceutica Nv |
SUBSTITUTED AMINOPROPENYLPIPERIDINE OR MORPHOLINE DERIVATIVES AS UNKNOWN INHIBITORS OF HISTONDEACETYLASE
|
|
JP5225103B2
(ja)
|
2006-01-19 |
2013-07-03 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ヒストン・デアセチラーゼの新規なインヒビターとしてのヘテロシクリルアルキル誘導体
|
|
EP1979326B1
(en)
|
2006-01-19 |
2012-10-03 |
Janssen Pharmaceutica N.V. |
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
|
|
US7888360B2
(en)
|
2006-01-19 |
2011-02-15 |
Janssen Pharmaceutica N.V. |
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
|
|
KR101533461B1
(ko)
|
2006-04-26 |
2015-07-02 |
에프. 호프만-라 로슈 아게 |
Ｐｉ３ｋ저해제로 유용한 티에노［3,2-ｄ］피리미딘 유도체
|
|
PL2041139T3
(pl)
|
2006-04-26 |
2012-05-31 |
Hoffmann La Roche |
Związki farmaceutyczne
|
|
AU2007243466B2
(en)
|
2006-04-26 |
2012-01-19 |
F. Hoffmann-La Roche Ag |
Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
|
|
EP2018366A4
(en)
|
2006-05-16 |
2010-08-04 |
Univ Mcgill |
HYBRID MOLECULES WITH MIXED VITAMIN D RECEPTOR AGONISM AND HISTONDEACETYLASE RESISTANT PROPERTIES
|
|
AU2007296740B2
(en)
|
2006-09-11 |
2012-09-27 |
Curis, Inc. |
Substituted 2-indolinone as PTK inhibitors containing a zinc binding moiety
|
|
WO2008033746A2
(en)
|
2006-09-11 |
2008-03-20 |
Curis, Inc. |
Tyrosine kinase inhibitors containing a zinc binding moiety
|
|
US20080161320A1
(en)
|
2006-09-11 |
2008-07-03 |
Xiong Cai |
Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
|
|
SG174772A1
(en)
|
2006-09-11 |
2011-10-28 |
Curis Inc |
Multi-functional small molecules as anti-proliferative agents
|
|
CA2662617C
(en)
|
2006-09-11 |
2014-11-18 |
Changgeng Qian |
Quinazoline based egfr inhibitors containing a zinc binding moiety
|
|
US7547781B2
(en)
|
2006-09-11 |
2009-06-16 |
Curis, Inc. |
Quinazoline based EGFR inhibitors containing a zinc binding moiety
|
|
CA2667826C
(en)
|
2006-10-28 |
2013-10-08 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
PE20081679A1
(es)
|
2006-12-07 |
2008-12-18 |
Hoffmann La Roche |
Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
|
|
CA2671845C
(en)
*
|
2006-12-07 |
2015-03-24 |
Genentech, Inc. |
Phosphoinositide 3-kinase inhibitor compounds and methods of use
|
|
CA2677651A1
(en)
|
2007-02-15 |
2008-08-21 |
Novartis Ag |
Combinations of therapeutic agents for treating cancer
|
|
US20080234332A1
(en)
|
2007-03-20 |
2008-09-25 |
Xiong Cai |
Raf kinase inhibitors containing a zinc binding moiety
|
|
TW200922590A
(en)
|
2007-09-10 |
2009-06-01 |
Curis Inc |
VEGFR inhibitors containing a zinc binding moiety
|
|
WO2009036066A1
(en)
|
2007-09-10 |
2009-03-19 |
Curis, Inc. |
Vegfr inhibitors containing a zinc binding moiety
|
|
WO2009036020A1
(en)
|
2007-09-10 |
2009-03-19 |
Curis, Inc. |
Mek inhibitors containing a zinc binding moiety
|
|
WO2009036057A1
(en)
|
2007-09-10 |
2009-03-19 |
Curis, Inc. |
Antiproliferative agents containing a zinc binding moiety
|
|
TW200922564A
(en)
|
2007-09-10 |
2009-06-01 |
Curis Inc |
CDK inhibitors containing a zinc binding moiety
|
|
BRPI0816769A2
(pt)
|
2007-09-12 |
2016-11-29 |
Hoffmann La Roche |
combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
|
|
WO2009042646A1
(en)
|
2007-09-24 |
2009-04-02 |
Curis, Inc. |
Anti-proliferative agents
|
|
WO2009055730A1
(en)
|
2007-10-25 |
2009-04-30 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
US20090149511A1
(en)
|
2007-10-30 |
2009-06-11 |
Syndax Pharmaceuticals, Inc. |
Administration of an Inhibitor of HDAC and an mTOR Inhibitor
|
|
WO2009086012A1
(en)
|
2007-12-20 |
2009-07-09 |
Curis, Inc. |
Aurora inhibitors containing a zinc binding moiety
|
|
EP2311842A3
(en)
|
2008-06-24 |
2011-07-13 |
Takeda Pharmaceutical Company Limited |
PI3K/M TOR inhibitors
|
|
WO2009155659A1
(en)
|
2008-06-27 |
2009-12-30 |
The University Of Queensland |
Combination therapy
|
|
US8196911B2
(en)
|
2008-10-27 |
2012-06-12 |
Honda Motor Co., Ltd. |
Adjustable rate subframe mount
|
|
PT2385832E
(pt)
*
|
2009-01-08 |
2015-11-02 |
Curis Inc |
Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco
|
|
WO2010089411A2
(en)
|
2009-02-09 |
2010-08-12 |
Universite De La Mediterranee |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
|
JP5709766B2
(ja)
*
|
2009-03-12 |
2015-04-30 |
ジェネンテック， インコーポレイテッド |
造血器腫瘍の治療のためのホスホイノシチド３キナーゼ阻害剤化合物と化学療法剤の併用
|
|
AU2010314287A1
(en)
|
2009-10-12 |
2012-05-03 |
F. Hoffmann-La Roche Ag |
Combinations of a PI3K inhibitor and a MEK inhibitor
|
|
CA2795952A1
(en)
*
|
2010-04-16 |
2011-10-20 |
Curis, Inc. |
Treatment of cancers having k-ras mutations
|
|
PT3111938T
(pt)
*
|
2011-04-01 |
2019-07-10 |
Curis Inc |
Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco
|
|
US20130102595A1
(en)
|
2011-04-15 |
2013-04-25 |
Curis, Inc. |
Treatment of cancers having k-ras mutations
|
|
BR112014002353B1
(pt)
|
2011-08-01 |
2022-09-27 |
Genentech, Inc |
Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
|
|
PT3313443T
(pt)
|
2015-06-25 |
2023-08-30 |
Immunomedics Inc |
Combinação de anticorpos anti-hla-dr ou anti-trop-2 com inibidores de microtúbulos, inibidores de parp, inibidores de bruton quinase ou inibidores de fosfoinositídeo 3-quinase melhora significativamente o resultado terapêutico no cancro
|
|
KR20190077040A
(ko)
*
|
2016-11-02 |
2019-07-02 |
쿠리스 인코퍼레이션 |
아연 결합 모이어티를 갖는 포스포이노시티드 3-키나아제 억제제를 이용하는 조합 요법
|