JP2014508930A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014508930A5 JP2014508930A5 JP2013554602A JP2013554602A JP2014508930A5 JP 2014508930 A5 JP2014508930 A5 JP 2014508930A5 JP 2013554602 A JP2013554602 A JP 2013554602A JP 2013554602 A JP2013554602 A JP 2013554602A JP 2014508930 A5 JP2014508930 A5 JP 2014508930A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- tnfα drug
- labeled
- therapy
- tnfα
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161444097P | 2011-02-17 | 2011-02-17 | |
| US61/444,097 | 2011-02-17 | ||
| US201161484594P | 2011-05-10 | 2011-05-10 | |
| US61/484,594 | 2011-05-10 | ||
| US201161496501P | 2011-06-13 | 2011-06-13 | |
| US61/496,501 | 2011-06-13 | ||
| PCT/US2012/025437 WO2012154253A1 (en) | 2011-02-17 | 2012-02-16 | ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508930A JP2014508930A (ja) | 2014-04-10 |
| JP2014508930A5 true JP2014508930A5 (cg-RX-API-DMAC7.html) | 2015-03-19 |
| JP6063398B2 JP6063398B2 (ja) | 2017-01-18 |
Family
ID=45809635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554602A Expired - Fee Related JP6063398B2 (ja) | 2011-02-17 | 2012-02-16 | 抗ＴＮＦα薬に対する自己抗体を検出するためのアッセイ |
Country Status (16)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| MX2012004877A (es) | 2009-10-26 | 2012-05-23 | Prometheus Lab Inc | Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos. |
| EP2630495B1 (en) | 2010-10-18 | 2017-02-08 | Nestec S.A. | Methods for determining anti-drug antibody isotypes |
| EP3130921B1 (en) | 2011-07-06 | 2018-09-12 | Nestec S.A. | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
| EP2904393B1 (en) | 2012-10-03 | 2018-11-28 | Gyros Patent Ab | Method and kit for analyte determination at acidic conditions |
| CN104838270A (zh) | 2012-10-05 | 2015-08-12 | 雀巢产品技术援助有限公司 | 用于预测和监测粘膜愈合的方法 |
| BR112015012482A2 (pt) * | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
| WO2014122600A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
| WO2014160883A1 (en) | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Treating fibrosis and inflammation by inhibiting tl1a |
| EP3498867B1 (en) | 2013-05-17 | 2021-09-29 | Cedars-Sinai Medical Center | Variants of tnfsf15 and dcr3 associated with crohn's disease |
| US10316083B2 (en) | 2013-07-19 | 2019-06-11 | Cedars-Sinai Medical Center | Signature of TL1A (TNFSF15) signaling pathway |
| WO2015083087A1 (en) | 2013-12-03 | 2015-06-11 | Nestec S.A. | Methods for predicting post-operative recurrence of crohn's disease |
| WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
| LT3105592T (lt) | 2014-02-11 | 2019-01-25 | Genzyme Corporation | Antikūnų prieš vaistus buvimo arba jų kiekio aptikimo analizė |
| BR112016023046A8 (pt) | 2014-04-04 | 2021-05-11 | Mayo Found Medical Education & Res | kit compreendendo anticorpos e agentes redutores |
| CN104034896A (zh) * | 2014-06-19 | 2014-09-10 | 华北制药集团新药研究开发有限责任公司 | 一种双抗体夹心elisa检测方法 |
| WO2016018978A1 (en) * | 2014-07-29 | 2016-02-04 | Mayo Foundation For Medical Education And Research | Quantifying monoclonal antibody therapeutics by lc-ms/ms |
| WO2016063204A1 (en) * | 2014-10-20 | 2016-04-28 | Nestec S.A. | Methods for prediction of anti-tnf alpha drug levels and autoantibody formation |
| EP3215853B1 (en) * | 2014-11-05 | 2022-11-16 | F. Hoffmann-La Roche AG | Method for the determination of anti-drug antibodies against an effector function suppressed human or humanized drug antibody |
| CN107250798A (zh) | 2014-12-05 | 2017-10-13 | 雀巢产品技术援助有限公司 | 用于检测患者样品中的生物制品的间接均相迁移率变动试验 |
| EP3243078A1 (en) | 2015-01-09 | 2017-11-15 | Atonomics A/S | A universal assay for determining the quantity of tnf inhibitory drugs and their corresponding anti-drug-antibodies |
| WO2016135707A1 (en) | 2015-02-27 | 2016-09-01 | Nestec S.A. | Diagnosis of major depressive disorder, mild cognitive impairment, and alzheimer's disease and other neurologic and psychiatric disorders |
| WO2017053932A1 (en) | 2015-09-24 | 2017-03-30 | Mayo Foundation For Medical Education And Research | Identification of immunoglobulin free light chains by mass spectrometry |
| ES2815224T3 (es) * | 2015-11-06 | 2021-03-29 | Promise Proteomics | Un método para cuantificar anticuerpos terapéuticos |
| KR20240095481A (ko) | 2016-03-17 | 2024-06-25 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| US11119096B2 (en) | 2016-07-08 | 2021-09-14 | W. Health L.P. | Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| EP3511713B1 (en) * | 2016-09-06 | 2021-10-27 | Fujirebio Inc. | Tumor marker measurement method and measurement reagent |
| EP3523647B1 (en) | 2016-09-07 | 2024-06-26 | Mayo Foundation for Medical Education and Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
| EP3681907A4 (en) | 2017-09-13 | 2021-07-07 | Mayo Foundation for Medical Education and Research | IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN J-CHAINS |
| WO2019055634A1 (en) | 2017-09-13 | 2019-03-21 | Mayo Foundation For Medical Education And Research | IDENTIFICATION AND MONITORING OF A MACROPHAGE APOPTOSIS INHIBITOR |
| EP3717916B1 (en) * | 2017-11-29 | 2025-01-01 | F. Hoffmann-La Roche AG | Target interference suppressed anti-drug antibody assay |
| US12385913B2 (en) * | 2018-08-03 | 2025-08-12 | Bristol-Myers Squibb Company | Methods for detecting anti-drug antibodies |
| AU2020222056A1 (en) | 2019-02-11 | 2021-10-07 | Phoenix Molecular Designs | Crystalline forms of an RSK inhibitor |
| JP2020115139A (ja) * | 2020-03-11 | 2020-07-30 | 国立大学法人千葉大学 | 血管炎の検査方法 |
| KR102562006B1 (ko) | 2020-11-09 | 2023-08-02 | 바디텍메드(주) | 항tnf-알파 약물 모니터링을 위한 신속 검출 키트 |
| CN112362649B (zh) * | 2020-11-09 | 2024-07-12 | 长春金赛药业有限责任公司 | 一种rhGH中和抗体的检测方法 |
| KR102568430B1 (ko) * | 2020-11-16 | 2023-08-24 | 바디텍메드(주) | 항 약물 항체의 신속 검출 방법 |
| CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459359A (en) * | 1981-11-19 | 1984-07-10 | New York Blood Center, Inc. | Sensitive immunoassays of antigens or antibodies sequestered within immune complexes |
| FR2590674B1 (fr) * | 1985-11-25 | 1989-03-03 | Inst Nat Sante Rech Med | Nouveaux reactifs de diagnostic |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| US5094740A (en) * | 1990-02-16 | 1992-03-10 | Glycomed, Inc. | Two-dimensional electrophoretic separation of carbohydrates |
| GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
| US6074835A (en) | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
| US6406862B1 (en) | 1998-10-06 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Army | Dip-stick assay for C-reactive protein |
| PT1159003E (pt) * | 1999-03-02 | 2011-02-22 | Centocor Inc | Anti-tnf alfa na terapêutica da asma resistente a esteróides |
| US6309643B1 (en) | 1999-04-30 | 2001-10-30 | The Regents Of The University Of California | IBD-associated microbial antigens and methods of using same |
| FR2802536B1 (fr) | 1999-11-23 | 2003-06-13 | Chru Lille | Oligomannosides de synthese, leur preparation et leur utilisation a la detection d'anticorps et a la prevention d'infections |
| FR2806739B1 (fr) | 2000-03-27 | 2005-02-18 | Fond Jean Dausset Ceph | Genes impliques dans les maladies inflammatoires de l'intestin et leur utilisation |
| US6838250B2 (en) | 2000-03-31 | 2005-01-04 | Ortho-Clinical Diagnostics, Inc. | Immunoassay for C-reactive protein |
| US7138237B1 (en) | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| DK1330525T3 (da) | 2000-10-30 | 2013-03-04 | Univ Michigan | NOD2-nukleinsyrer og proteiner |
| ES2486340T3 (es) | 2000-10-30 | 2014-08-18 | The Regents Of The University Of Michigan | Ácidos nucleicos y proteínas Nod2 |
| EP1340078B1 (en) | 2000-11-14 | 2009-05-27 | Techlab, Inc. | Method for differentiating irritable bowel syndrome from inflammatory bowel disease (ibd) and for monitoring persons with ibd using total endogenous lactoferrin as a marker |
| ES2405790T3 (es) | 2001-12-17 | 2013-06-03 | Corixa Corporation | Composiciones y métodos para la terapia y el diagnóstico de enfermedad inflamatoria del intestino |
| US20040053263A1 (en) | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| ATE395596T1 (de) | 2002-10-25 | 2008-05-15 | Techlab Inc | Diagnostisches panel ibd-first chek fur entzundliche darmerkrankung (ibd) und reizkolon |
| US7662569B2 (en) | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
| CA2549971A1 (en) | 2003-11-03 | 2005-05-12 | Duke University | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke |
| US20060003384A1 (en) * | 2004-06-30 | 2006-01-05 | Wagner Carrie L | Detection of measurement of antibodies to antigenic proteins in biological tissues or samples |
| US20060019410A1 (en) | 2004-07-21 | 2006-01-26 | Qualyst, Inc. | Apparatus, kits and methods for evaluating binding interactions, for detecting and quantifying binding molecules, and for sample preparation |
| JP2007147367A (ja) * | 2005-11-25 | 2007-06-14 | Sekisui Chem Co Ltd | サイトカイン産生能の測定方法 |
| US20110066624A1 (en) | 2006-08-01 | 2011-03-17 | Divyank Turakhia | system and method of generating related words and word concepts |
| MX2009003048A (es) | 2006-09-21 | 2009-09-07 | Prometheus Lab Inc | Disposiciones a base de anticuerpo para detectar transductores de multiple señal en celulas circulantes raras. |
| BRPI0813583A2 (pt) | 2007-07-13 | 2014-12-30 | Prometheus Lab Inc | Métodos para selecionar um medicamento anticâncer, para identificar a resposta de um tumor pulmonar, e para prognosticar a resposta de um paciente, e, arranjo |
| US20090035216A1 (en) * | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
| WO2009022001A1 (en) * | 2007-08-16 | 2009-02-19 | Novartis Ag | Improvement of drug tolerance in immunogenicity testing |
| US20110020840A1 (en) * | 2008-01-15 | 2011-01-27 | Gerrit Jan Wolbink | Method and kits for detecting antibodies against therapeutic antibodies |
| EP2602623B1 (en) | 2008-02-25 | 2015-09-16 | Nestec S.A. | Mehtod for the detection of intracellular truncated receptors |
| WO2010042031A1 (en) * | 2008-10-07 | 2010-04-15 | Gyros Patent Ab | Semi-sequential assay for detection of an analyte in a sample |
| JP5718319B2 (ja) | 2009-05-14 | 2015-05-13 | ネステク ソシエテ アノニム | Ｈｅｒ２標的化療法に対する乳癌細胞の感受性を決定するためのバイオマーカー |
| AU2010273319B2 (en) | 2009-07-15 | 2015-01-22 | Nestec S.A. | Drug selection for gastric cancer therapy using antibody-based arrays |
| US8408369B2 (en) | 2009-09-08 | 2013-04-02 | GM Global Technology Operations LLC | Bimetallic brake rotor |
| CN102667478B (zh) | 2009-10-20 | 2018-06-01 | 雀巢产品技术援助有限公司 | 用于检测致癌融合蛋白的邻近介导试验 |
| MX2012004877A (es) * | 2009-10-26 | 2012-05-23 | Prometheus Lab Inc | Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos. |
-
2012
- 2012-02-16 DK DK12707193.4T patent/DK2676137T3/en active
- 2012-02-16 AU AU2012254150A patent/AU2012254150B2/en not_active Ceased
- 2012-02-16 BR BR112013020981A patent/BR112013020981A2/pt not_active Application Discontinuation
- 2012-02-16 WO PCT/US2012/025437 patent/WO2012154253A1/en not_active Ceased
- 2012-02-16 SG SG2013061692A patent/SG192770A1/en unknown
- 2012-02-16 CA CA2827609A patent/CA2827609A1/en not_active Abandoned
- 2012-02-16 MX MX2013009570A patent/MX343327B/es active IP Right Grant
- 2012-02-16 EP EP12707193.4A patent/EP2676137B1/en active Active
- 2012-02-16 KR KR1020137024583A patent/KR20140008397A/ko not_active Ceased
- 2012-02-16 JP JP2013554602A patent/JP6063398B2/ja not_active Expired - Fee Related
- 2012-02-16 CN CN201280018741.1A patent/CN103502815B/zh not_active Expired - Fee Related
- 2012-02-16 ES ES12707193.4T patent/ES2530175T3/es active Active
- 2012-02-16 RU RU2013142278/15A patent/RU2013142278A/ru not_active Application Discontinuation
-
2013
- 2013-08-07 US US13/961,841 patent/US20140045276A1/en not_active Abandoned
- 2013-09-03 IL IL227853A patent/IL227853A/en active IP Right Grant
- 2013-09-16 ZA ZA2013/06950A patent/ZA201306950B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014508930A5 (cg-RX-API-DMAC7.html) | ||
| RU2013142278A (ru) | ТЕСТЫ ДЛЯ ДЕТЕКЦИИ АУТОАНТИТЕЛ К АНТИ-TNFα ЛЕКАРСТВЕННЫМ СРЕДСТВАМ | |
| Vande Casteele et al. | Antibody response to infliximab and its impact on pharmacokinetics can be transient | |
| Luo et al. | Synthesis of novel haptens and development of an enzyme-linked immunosorbent assay for quantification of histamine in foods | |
| JP2013508739A5 (cg-RX-API-DMAC7.html) | ||
| WO2022048052A1 (zh) | 新冠病毒中和毒性的纳米抗体及其制备方法与应用 | |
| JP2014525036A5 (cg-RX-API-DMAC7.html) | ||
| Adrait et al. | Development of a Protein Standard Absolute Quantification (PSAQ™) assay for the quantification of Staphylococcus aureus enterotoxin A in serum | |
| JP2002521391A5 (cg-RX-API-DMAC7.html) | ||
| Zhu et al. | A rapid cIEF–ESI–MS/MS method for host cell protein analysis of a recombinant human monoclonal antibody | |
| RU2014146707A (ru) | Антитела против тофацитиниба и их применение для лекарственного мониторинга | |
| Hicks et al. | Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development | |
| JP2016531546A5 (cg-RX-API-DMAC7.html) | ||
| JP2013535963A5 (cg-RX-API-DMAC7.html) | ||
| Umemura et al. | Serum sodium concentration is associated with increased risk of mortality in patients with compensated liver cirrhosis | |
| JP2016502091A5 (cg-RX-API-DMAC7.html) | ||
| CN106432491A (zh) | 一种TNF‑α蛋白纳米抗体及其编码序列及应用 | |
| CN102936283B (zh) | 抗人cd146的单克隆抗体，包含其的组合物，检测可溶性cd146的方法 | |
| Cui et al. | An indirect competitive enzyme-linked immunosorbent assay for determination of norfloxacin in waters using a specific polyclonal antibody | |
| Xu et al. | Monoclonal antibody-based enzyme-linked immunosorbent assay for detection of total malachite green and crystal violet residues in fishery products | |
| CN102719405A (zh) | 杂交瘤细胞株1c8及其产生的抗黄曲霉毒素g1单克隆抗体 | |
| Hu et al. | Monoclonal antibody based enzyme-linked immunosorbent assay for the specific detection of ciprofloxacin and enrofloxacin residues in fishery products | |
| JP2017526618A5 (cg-RX-API-DMAC7.html) | ||
| CN101781365A (zh) | 一种河豚毒素的人工抗原、相应的特异性抗体及其制备方法与应用 | |
| Chen et al. | Quantification of testosterone and epitestosterone in biological samples by capillary electrophoresis with immunoaffinity extraction |