JP2016502091A5 - - Google Patents
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- Publication number
- JP2016502091A5 JP2016502091A5 JP2015544592A JP2015544592A JP2016502091A5 JP 2016502091 A5 JP2016502091 A5 JP 2016502091A5 JP 2015544592 A JP2015544592 A JP 2015544592A JP 2015544592 A JP2015544592 A JP 2015544592A JP 2016502091 A5 JP2016502091 A5 JP 2016502091A5
- Authority
- JP
- Japan
- Prior art keywords
- tnfα
- labeled
- sample
- agents
- autoantibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 28
- 239000000523 sample Substances 0.000 claims 21
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 20
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 20
- 229940079593 drug Drugs 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 20
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 18
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 18
- 239000013068 control sample Substances 0.000 claims 8
- 238000006386 neutralization reaction Methods 0.000 claims 7
- 230000003472 neutralizing effect Effects 0.000 claims 6
- 238000001542 size-exclusion chromatography Methods 0.000 claims 6
- 239000013074 reference sample Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 229960001743 golimumab Drugs 0.000 claims 2
- 230000002123 temporal effect Effects 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732251P | 2012-11-30 | 2012-11-30 | |
| US61/732,251 | 2012-11-30 | ||
| US13/802,117 US20130266963A1 (en) | 2011-07-06 | 2013-03-13 | Assay for detecting neutralizing autoantibodies to biologic therapy |
| US13/802,117 | 2013-03-13 | ||
| PCT/IB2013/060458 WO2014083520A2 (en) | 2012-11-30 | 2013-11-27 | Assays for detecting neutralizing autoantibodies to biologic therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016502091A JP2016502091A (ja) | 2016-01-21 |
| JP2016502091A5 true JP2016502091A5 (cg-RX-API-DMAC7.html) | 2017-01-05 |
Family
ID=50828561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544592A Pending JP2016502091A (ja) | 2012-11-30 | 2013-11-27 | 生物学的治療に対する中和自己抗体の検出のためのアッセイ |
Country Status (13)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012004877A (es) | 2009-10-26 | 2012-05-23 | Prometheus Lab Inc | Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos. |
| EP2630495B1 (en) | 2010-10-18 | 2017-02-08 | Nestec S.A. | Methods for determining anti-drug antibody isotypes |
| EP3130921B1 (en) | 2011-07-06 | 2018-09-12 | Nestec S.A. | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
| CN107250798A (zh) | 2014-12-05 | 2017-10-13 | 雀巢产品技术援助有限公司 | 用于检测患者样品中的生物制品的间接均相迁移率变动试验 |
| EP3243078A1 (en) | 2015-01-09 | 2017-11-15 | Atonomics A/S | A universal assay for determining the quantity of tnf inhibitory drugs and their corresponding anti-drug-antibodies |
| US11119096B2 (en) | 2016-07-08 | 2021-09-14 | W. Health L.P. | Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| WO2018178307A1 (en) | 2017-03-31 | 2018-10-04 | Ablynx N.V. | Improved immunogenicity assays |
| EP4085254B1 (en) * | 2020-01-02 | 2024-06-05 | F. Hoffmann-La Roche AG | Ada-response specification assay |
| CN111024958B (zh) * | 2020-03-11 | 2020-06-23 | 同昕生物技术（北京）有限公司 | 用于检测单抗药物和抗单抗药物抗体的试剂及其应用 |
| CN112730846B (zh) * | 2020-12-18 | 2023-12-15 | 安渡生物医药(杭州)有限公司 | 一种用于小鼠血样检测免疫复合物的方法 |
| CN114047343B (zh) * | 2022-01-13 | 2022-05-31 | 美迪西普亚医药科技(上海)有限公司 | 双耐受型抗IgE单抗药物的免疫原性分析试剂盒及其使用方法和应用 |
| CN117871856A (zh) * | 2023-12-15 | 2024-04-12 | 首都医科大学附属北京地坛医院 | 可溶性因子在无症状神经梅毒检测中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012004877A (es) * | 2009-10-26 | 2012-05-23 | Prometheus Lab Inc | Analisis para la deteccion de farmacos anti-tnf y autoanticuerpos. |
| RS54249B1 (sr) * | 2010-04-29 | 2016-02-29 | Theradiag Sa | Postupak za detekciju anti-lek antitela |
| EP2630495B1 (en) * | 2010-10-18 | 2017-02-08 | Nestec S.A. | Methods for determining anti-drug antibody isotypes |
| DK2676137T3 (en) * | 2011-02-17 | 2015-01-19 | Nestec Sa | TESTS TO DETECT AUTO ANTIBODIES FOR ANTI-TNF PHARMACEUTICALS |
| EP3130921B1 (en) * | 2011-07-06 | 2018-09-12 | Nestec S.A. | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
-
2013
- 2013-11-21 BR BR112015012482A patent/BR112015012482A2/pt not_active IP Right Cessation
- 2013-11-27 WO PCT/IB2013/060458 patent/WO2014083520A2/en not_active Ceased
- 2013-11-27 HK HK16103834.6A patent/HK1215969A1/zh unknown
- 2013-11-27 SG SG10201703210XA patent/SG10201703210XA/en unknown
- 2013-11-27 EP EP13820955.6A patent/EP2926136A2/en not_active Withdrawn
- 2013-11-27 CA CA2892766A patent/CA2892766A1/en not_active Abandoned
- 2013-11-27 MX MX2015006852A patent/MX2015006852A/es unknown
- 2013-11-27 CN CN201380071748.4A patent/CN105074461A/zh active Pending
- 2013-11-27 JP JP2015544592A patent/JP2016502091A/ja active Pending
- 2013-11-27 RU RU2015125739A patent/RU2015125739A/ru not_active Application Discontinuation
- 2013-11-27 AU AU2013350817A patent/AU2013350817A1/en not_active Abandoned
- 2013-11-27 SG SG11201504097PA patent/SG11201504097PA/en unknown
- 2013-11-27 KR KR1020157017311A patent/KR20150088890A/ko not_active Withdrawn
-
2015
- 2015-05-25 IL IL238995A patent/IL238995A0/en unknown
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