ZA201306950B - ASSAYS FOR DETECTING AUTOANTIBODIES TO ANFI-TNFa DRUGS - Google Patents

ASSAYS FOR DETECTING AUTOANTIBODIES TO ANFI-TNFa DRUGS

Info

Publication number
ZA201306950B
ZA201306950B ZA2013/06950A ZA201306950A ZA201306950B ZA 201306950 B ZA201306950 B ZA 201306950B ZA 2013/06950 A ZA2013/06950 A ZA 2013/06950A ZA 201306950 A ZA201306950 A ZA 201306950A ZA 201306950 B ZA201306950 B ZA 201306950B
Authority
ZA
South Africa
Prior art keywords
anfi
assays
detecting autoantibodies
tnfa drugs
tnfa
Prior art date
Application number
ZA2013/06950A
Other languages
English (en)
Inventor
Sharat Singh
Linda Chrmund
Shui Long Wang
Scott Hauenstein
Original Assignee
Nestec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nestec Sa filed Critical Nestec Sa
Publication of ZA201306950B publication Critical patent/ZA201306950B/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA2013/06950A 2011-02-17 2013-09-16 ASSAYS FOR DETECTING AUTOANTIBODIES TO ANFI-TNFa DRUGS ZA201306950B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161444097P 2011-02-17 2011-02-17
US201161484594P 2011-05-10 2011-05-10
US201161496501P 2011-06-13 2011-06-13
PCT/US2012/025437 WO2012154253A1 (en) 2011-02-17 2012-02-16 ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS

Publications (1)

Publication Number Publication Date
ZA201306950B true ZA201306950B (en) 2015-04-29

Family

ID=45809635

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2013/06950A ZA201306950B (en) 2011-02-17 2013-09-16 ASSAYS FOR DETECTING AUTOANTIBODIES TO ANFI-TNFa DRUGS

Country Status (16)

Country Link
US (1) US20140045276A1 (cg-RX-API-DMAC7.html)
EP (1) EP2676137B1 (cg-RX-API-DMAC7.html)
JP (1) JP6063398B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140008397A (cg-RX-API-DMAC7.html)
CN (1) CN103502815B (cg-RX-API-DMAC7.html)
AU (1) AU2012254150B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013020981A2 (cg-RX-API-DMAC7.html)
CA (1) CA2827609A1 (cg-RX-API-DMAC7.html)
DK (1) DK2676137T3 (cg-RX-API-DMAC7.html)
ES (1) ES2530175T3 (cg-RX-API-DMAC7.html)
IL (1) IL227853A (cg-RX-API-DMAC7.html)
MX (1) MX343327B (cg-RX-API-DMAC7.html)
RU (1) RU2013142278A (cg-RX-API-DMAC7.html)
SG (1) SG192770A1 (cg-RX-API-DMAC7.html)
WO (1) WO2012154253A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201306950B (cg-RX-API-DMAC7.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
NZ599456A (en) 2009-10-26 2014-06-27 Nestec Sa Assays for the detection of anti-tnf drugs and autoantibodies
AU2011317149B2 (en) 2010-10-18 2015-05-07 Société des Produits Nestlé S.A. Methods for determining anti-drug antibody isotypes
SG10201605516YA (en) 2011-07-06 2016-08-30 Nestec Sa Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha
JP6279590B2 (ja) 2012-10-03 2018-02-14 ユィロス・パテント・アクチボラグＧｙｒｏｓ Ｐａｔｅｎｔ ＡＢ 酸性条件でアナライトを測定するための方法およびキット
ES2638971T3 (es) 2012-10-05 2017-10-24 Nestec S.A. Métodos para predecir y monitorizar la cicatrización de la mucosa
BR112015012482A2 (pt) * 2012-11-30 2017-07-11 Nestec Sa ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos
WO2014122600A1 (en) 2013-02-05 2014-08-14 Nestec S.A. Methods of selecting combination therapy for colorectal cancer patients
CA2908553A1 (en) 2013-03-27 2014-10-02 Cedars-Sinai Medical Center Mitigation and reversal of fibrosis and inflammation by inhibition of tl1a function and related signaling pathways
KR20210107176A (ko) 2013-05-17 2021-08-31 세다르스-신나이 메디칼 센터 크론병과 연관된 tnfsf15와 dcr3의 변이체
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
EP3654037A1 (en) 2013-12-03 2020-05-20 Prometheus Biosciences, Inc. Methods for predicting post-operative recurrence of crohn's disease
WO2015110989A1 (en) 2014-01-23 2015-07-30 Nestec S.A. Biomarker panel for assessment of mucosal healing
EP3667321B1 (en) 2014-02-11 2022-07-27 Genzyme Corporation Assays for detecting the presence or amount of an anti-drug antibody
AU2015240454B2 (en) 2014-04-04 2019-08-22 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
CN104034896A (zh) * 2014-06-19 2014-09-10 华北制药集团新药研究开发有限责任公司 一种双抗体夹心elisa检测方法
WO2016018978A1 (en) * 2014-07-29 2016-02-04 Mayo Foundation For Medical Education And Research Quantifying monoclonal antibody therapeutics by lc-ms/ms
MX2017004742A (es) * 2014-10-20 2017-07-20 Nestec Sa Métodos para la predicción de niveles de farmacos anti-tnf alfa y formación de autoanticuerpos.
EP3736575B1 (en) * 2014-11-05 2024-08-28 F. Hoffmann-La Roche AG Method for the determination of anti-drug antibodies against an effector function suppressed human or humanized drug antibody
EP3227683B1 (en) 2014-12-05 2019-04-24 Nestec S.A. Indirect homogeneous mobility shift assays for the detection of biologics in patient samples
US11085931B2 (en) 2015-01-09 2021-08-10 W. Health L.P. Universal assay for determining the quantity of TNFα inhibitory drugs and their corresponding anti-drug-antibodies
WO2016135707A1 (en) 2015-02-27 2016-09-01 Nestec S.A. Diagnosis of major depressive disorder, mild cognitive impairment, and alzheimer's disease and other neurologic and psychiatric disorders
JP6968058B2 (ja) 2015-09-24 2021-11-17 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 質量分析法による免疫グロブリン遊離軽鎖の同定
ES2815224T3 (es) * 2015-11-06 2021-03-29 Promise Proteomics Un método para cuantificar anticuerpos terapéuticos
JP7082945B2 (ja) 2016-03-17 2022-06-09 シーダーズ―シナイ メディカル センター Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法
US11119096B2 (en) 2016-07-08 2021-09-14 W. Health L.P. Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples
WO2018047793A1 (ja) * 2016-09-06 2018-03-15 富士レビオ株式会社 腫瘍マーカーの測定方法及び測定試薬
WO2018049001A1 (en) 2016-09-07 2018-03-15 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
US12153052B2 (en) 2017-09-13 2024-11-26 Mayo Foundation For Medical Education And Research Identification and monitoring of immunoglobulin J chains
WO2019055634A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research IDENTIFICATION AND MONITORING OF A MACROPHAGE APOPTOSIS INHIBITOR
WO2019105916A1 (en) * 2017-11-29 2019-06-06 F. Hoffmann-La Roche Ag Target interference suppressed anti-drug antibody assay
CN112534263A (zh) * 2018-08-03 2021-03-19 百时美施贵宝公司 用于检测抗药抗体的方法
JP2022520382A (ja) 2019-02-11 2022-03-30 フェニックス モレキュラー デザインズ Ｒｓｋ阻害剤の結晶形態
JP2020115139A (ja) * 2020-03-11 2020-07-30 国立大学法人千葉大学 血管炎の検査方法
KR102562006B1 (ko) 2020-11-09 2023-08-02 바디텍메드(주) 항tnf-알파 약물 모니터링을 위한 신속 검출 키트
CN112362649B (zh) * 2020-11-09 2024-07-12 长春金赛药业有限责任公司 一种rhGH中和抗体的检测方法
KR102568430B1 (ko) * 2020-11-16 2023-08-24 바디텍메드(주) 항 약물 항체의 신속 검출 방법
CN114236139A (zh) * 2021-12-30 2022-03-25 苏州和锐生物科技有限公司 一种TNF-α生物制剂的抗体检测试剂盒、制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4459359A (en) * 1981-11-19 1984-07-10 New York Blood Center, Inc. Sensitive immunoassays of antigens or antibodies sequestered within immune complexes
FR2590674B1 (fr) * 1985-11-25 1989-03-03 Inst Nat Sante Rech Med Nouveaux reactifs de diagnostic
DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
US5094740A (en) * 1990-02-16 1992-03-10 Glycomed, Inc. Two-dimensional electrophoretic separation of carbohydrates
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
US6074835A (en) 1996-04-12 2000-06-13 Regents Of The Univ. Of California Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
US6033864A (en) 1996-04-12 2000-03-07 The Regents Of The University Of California Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
US6406862B1 (en) 1998-10-06 2002-06-18 The United States Of America As Represented By The Secretary Of The Army Dip-stick assay for C-reactive protein
CA2364026C (en) * 1999-03-02 2012-08-21 Centocor, Inc. Anti-tnf.alpha. antibodies in therapy of asthma
US6309643B1 (en) 1999-04-30 2001-10-30 The Regents Of The University Of California IBD-associated microbial antigens and methods of using same
FR2802536B1 (fr) 1999-11-23 2003-06-13 Chru Lille Oligomannosides de synthese, leur preparation et leur utilisation a la detection d'anticorps et a la prevention d'infections
FR2806739B1 (fr) 2000-03-27 2005-02-18 Fond Jean Dausset Ceph Genes impliques dans les maladies inflammatoires de l'intestin et leur utilisation
US6838250B2 (en) 2000-03-31 2005-01-04 Ortho-Clinical Diagnostics, Inc. Immunoassay for C-reactive protein
US7138237B1 (en) 2000-05-19 2006-11-21 Cedars-Sinai Medical Center Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen
WO2002036773A2 (en) 2000-10-30 2002-05-10 Regents Of The University Of Michigan Nod2 nucleic acids and proteins
AU4341502A (en) 2000-10-30 2002-06-11 Univ Michigan Nod2 nucleic acids and proteins
EP1340078B1 (en) 2000-11-14 2009-05-27 Techlab, Inc. Method for differentiating irritable bowel syndrome from inflammatory bowel disease (ibd) and for monitoring persons with ibd using total endogenous lactoferrin as a marker
AU2002365279B2 (en) 2001-12-17 2009-08-13 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
US20040053263A1 (en) 2002-08-30 2004-03-18 Abreu Maria T. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
CA2502976C (en) 2002-10-25 2012-05-22 Techlab, Inc. Inflammatory bowel disease and irritable bowel syndrome ibd-first chek diagnostic panel
US7662569B2 (en) 2003-04-11 2010-02-16 Cedars-Sinai Medical Center Methods of assessing Crohn's disease patient phenotype by I2 serologic response
EP1687447A4 (en) 2003-11-03 2008-04-02 Univ Duke METHOD FOR IDENTIFYING INDIVIDUALS IN THE HAZARD OF PERIOPERATIVE BLOODING, A KIDNEY PROBLEM OR A STROKE
EP1769244A4 (en) * 2004-06-30 2008-05-14 Dow Kenneth Centocor Inc DETECTION OR MEASUREMENT OF ANTIGEN PROTEIN ANTIBODIES IN BIOLOGICAL TISSUE OR SAMPLES
US20060019410A1 (en) 2004-07-21 2006-01-26 Qualyst, Inc. Apparatus, kits and methods for evaluating binding interactions, for detecting and quantifying binding molecules, and for sample preparation
JP2007147367A (ja) * 2005-11-25 2007-06-14 Sekisui Chem Co Ltd サイトカイン産生能の測定方法
WO2008059515A2 (en) 2006-08-01 2008-05-22 Divyank Turakhia A system and method of generating related words and word concepts
RU2442171C2 (ru) 2006-09-21 2012-02-10 Промитьюс Лабораториз Инк. Чипы на основе антител для определения множественных трансдукторов сигналов в редких циркулирующих клетках
AU2008276251B2 (en) 2007-07-13 2014-04-24 Nestec S.A. Drug selection for lung cancer therapy using antibody-based arrays
US20090035216A1 (en) * 2007-08-03 2009-02-05 Biomonitor Aps Method for determining in vivo biopharmaceutical concentration or bioavailability
WO2009022001A1 (en) * 2007-08-16 2009-02-19 Novartis Ag Improvement of drug tolerance in immunogenicity testing
US20110020840A1 (en) * 2008-01-15 2011-01-27 Gerrit Jan Wolbink Method and kits for detecting antibodies against therapeutic antibodies
EP2602623B1 (en) 2008-02-25 2015-09-16 Nestec S.A. Mehtod for the detection of intracellular truncated receptors
JP5634405B2 (ja) * 2008-10-07 2014-12-03 ユィロス・パテント・アクチボラグＧｙｒｏｓ Ｐａｔｅｎｔ ＡＢ 試料中のアナライトの検出のための半逐次アッセイ
EP2430443B1 (en) 2009-05-14 2018-06-27 Pierian Holdings, Inc. Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy
EP2454598B1 (en) 2009-07-15 2017-03-22 DiaTech Holdings, Inc. Drug selection for gastric cancer therapy using antibody-based arrays
US8408369B2 (en) 2009-09-08 2013-04-02 GM Global Technology Operations LLC Bimetallic brake rotor
CA2777934A1 (en) 2009-10-20 2011-04-28 Prometheus Laboratories Inc. Proximity-mediated assays for detecting oncogenic fusion proteins
NZ599456A (en) * 2009-10-26 2014-06-27 Nestec Sa Assays for the detection of anti-tnf drugs and autoantibodies

Also Published As

Publication number Publication date
IL227853A (en) 2017-07-31
HK1191688A1 (en) 2014-08-01
BR112013020981A2 (pt) 2016-10-11
EP2676137B1 (en) 2014-12-31
CN103502815B (zh) 2015-09-23
MX343327B (es) 2016-11-01
KR20140008397A (ko) 2014-01-21
EP2676137A1 (en) 2013-12-25
IL227853A0 (en) 2013-09-30
AU2012254150B2 (en) 2015-08-13
US20140045276A1 (en) 2014-02-13
AU2012254150A1 (en) 2013-05-02
ES2530175T3 (es) 2015-02-26
NZ614170A (en) 2015-04-24
CA2827609A1 (en) 2012-11-15
RU2013142278A (ru) 2015-03-27
DK2676137T3 (en) 2015-01-19
MX2013009570A (es) 2013-09-06
CN103502815A (zh) 2014-01-08
JP6063398B2 (ja) 2017-01-18
SG192770A1 (en) 2013-09-30
JP2014508930A (ja) 2014-04-10
WO2012154253A1 (en) 2012-11-15

Similar Documents

Publication Publication Date Title
ZA201306950B (en) ASSAYS FOR DETECTING AUTOANTIBODIES TO ANFI-TNFa DRUGS
IL228001A0 (en) Antibodies to 70cd
EP2550351A4 (en) DETECTION SYSTEM FOR DROPLET-BASED ANALYZES
IL222533A0 (en) Methods for detecting antibodies
EP2775373A4 (en) DEVICE FOR DETECTING THE AMPLITUDE OF THE MANUFACTURE OF A PEDAL
ZA201404463B (en) Detecting analytes
EP2756118A4 (en) METHOD FOR DETECTING SEPSIS
EP2797319A4 (en) CONTENT DELIVERY SYSTEM
EP2708903A4 (en) ANGULAR ACCELERATION DETECTOR ELEMENT
PL2756306T3 (pl) Sposób wykrywania antybiotyków
EP2598652A4 (en) TESTS FOR THE DETECTION OF GLYCOSAMINOGLYCANES
SI2639312T1 (sl) Imunski test za detekcijo miRNA
PL2753928T3 (pl) Kompozycje i sposoby wykrywania autoprzeciwciał
GB201106615D0 (en) Assay
EP2809796A4 (en) TESTS FOR THE DETECTION OF GLYCOSAMINOGLYCANES
SG11201405910SA (en) System for measuring a zone of separation in a substrate
GB2496294B (en) Improved indication system
IL228564A0 (en) Steroid receptor testers to detect mast cells
DE102011014839A8 (de) Wägesystem
GB201102659D0 (en) Assay
GB201117142D0 (en) Detection system
GB201121265D0 (en) Assay
GB201113101D0 (en) Assay
GB201121430D0 (en) Trunklid sensing system
GB201103968D0 (en) Detecting polypeptides