JP2014508759A - シアリル化抗体の生産の方法 - Google Patents

シアリル化抗体の生産の方法 Download PDF

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JP2014508759A
JP2014508759A JP2013554892A JP2013554892A JP2014508759A JP 2014508759 A JP2014508759 A JP 2014508759A JP 2013554892 A JP2013554892 A JP 2013554892A JP 2013554892 A JP2013554892 A JP 2013554892A JP 2014508759 A JP2014508759 A JP 2014508759A
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antibody
seq
domain
sequence
antiabeta
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JP2014508759A5 (enExample
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ブランシユ，フランシス
カムロン，ベアトリス
ジユネ，ブリユノ
スブリエ，フアブリエンヌ
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2013554892A 2011-02-24 2012-02-23 シアリル化抗体の生産の方法 Pending JP2014508759A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11305200.5 2011-02-24
EP11305200 2011-02-24
EP11306090.9 2011-09-01
EP11306090 2011-09-01
PCT/EP2012/053065 WO2012113863A1 (en) 2011-02-24 2012-02-23 Method of production of sialylated antibodies

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JP2014508759A true JP2014508759A (ja) 2014-04-10
JP2014508759A5 JP2014508759A5 (enExample) 2015-02-19

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JP2013554892A Pending JP2014508759A (ja) 2011-02-24 2012-02-23 シアリル化抗体の生産の方法

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US (1) US20140046032A1 (enExample)
EP (1) EP2678357A1 (enExample)
JP (1) JP2014508759A (enExample)
AR (1) AR085302A1 (enExample)
TW (1) TW201241182A (enExample)
WO (1) WO2012113863A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP2020515524A (ja) * 2017-01-31 2020-05-28 サノフイＳａｎｏｆｉ ベータアミロイドペプチドのプロトフィブリル形態に特異的な抗体の神経細胞保護作用
JP2021522216A (ja) * 2018-04-20 2021-08-30 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 高度にシアル化された自己抗体およびその使用

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US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US10450361B2 (en) 2013-03-15 2019-10-22 Momenta Pharmaceuticals, Inc. Methods related to CTLA4-Fc fusion proteins
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HK1221741A1 (zh) 2013-07-05 2017-06-09 F. Hoffmann-La Roche Ag 用於使用N-末端截短的β-半乳糖苷-α-2，6-唾液酸转移酶变体的糖蛋白的单-和二唾液酸化的方法
EP2824176A1 (en) 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
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US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP4640239A2 (en) 2014-03-19 2025-10-29 Genzyme Corporation Site-specific glycoengineering of targeting moieties
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3037527A1 (en) * 2014-12-22 2016-06-29 F. Hoffmann-La Roche AG Sialyltransferase without CMP-dependent sialidase activity
EP3237608B1 (en) * 2014-12-22 2019-10-09 F. Hoffmann-La Roche AG Cmp-dependent sialidase activity
US11337975B2 (en) 2016-11-23 2022-05-24 Acetylon Pharmaceuticals, Inc. Pharmaceutical combinations comprising a histone deacetylase inhibitor and a CD38 inhibitor and methods of use thereof
MA55529A (fr) 2019-04-03 2022-02-09 Genzyme Corp Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
WO2023086793A1 (en) * 2021-11-09 2023-05-19 Amgen Inc. Production of therapeutic proteins
WO2025101901A1 (en) * 2023-11-10 2025-05-15 The Board Of Trustees Of The Leland Stanford Junior University Use of sialylated ivig or igg fc region-containing protein for preventing or treating respiratory virus diseases

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JP2010510801A (ja) * 2006-11-28 2010-04-08 サントリオン 生物学的活性が向上した修飾可溶性ＦＧＦ受容体Ｆｃ融合物
JP2010512306A (ja) * 2006-10-27 2010-04-22 ザ ロックフェラー ユニバーシティー 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020515524A (ja) * 2017-01-31 2020-05-28 サノフイＳａｎｏｆｉ ベータアミロイドペプチドのプロトフィブリル形態に特異的な抗体の神経細胞保護作用
JP2021522216A (ja) * 2018-04-20 2021-08-30 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 高度にシアル化された自己抗体およびその使用

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WO2012113863A1 (en) 2012-08-30
AR085302A1 (es) 2013-09-18
EP2678357A1 (en) 2014-01-01
US20140046032A1 (en) 2014-02-13
TW201241182A (en) 2012-10-16

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