JP2014502967A5 - - Google Patents
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- JP2014502967A5 JP2014502967A5 JP2013546430A JP2013546430A JP2014502967A5 JP 2014502967 A5 JP2014502967 A5 JP 2014502967A5 JP 2013546430 A JP2013546430 A JP 2013546430A JP 2013546430 A JP2013546430 A JP 2013546430A JP 2014502967 A5 JP2014502967 A5 JP 2014502967A5
- Authority
- JP
- Japan
- Prior art keywords
- mutein
- binding protein
- amino acid
- acid substitution
- generation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000014914 Carrier Proteins Human genes 0.000 claims 17
- 108091008324 binding proteins Proteins 0.000 claims 17
- 108010002350 Interleukin-2 Proteins 0.000 claims 14
- 102000000588 Interleukin-2 Human genes 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 11
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 10
- 102220427331 c.274A>T Human genes 0.000 claims 9
- 102200142011 rs121909050 Human genes 0.000 claims 9
- 102200131576 rs121912452 Human genes 0.000 claims 9
- 102200158049 rs387906619 Human genes 0.000 claims 9
- 102200005671 rs1013940 Human genes 0.000 claims 5
- 102200004150 rs147750704 Human genes 0.000 claims 4
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 3
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 3
- 102220606633 Zinc finger protein GLIS1_Q74N_mutation Human genes 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 3
- 230000005593 dissociations Effects 0.000 claims 3
- 102220058213 rs730881465 Human genes 0.000 claims 2
- 108700004922 F42A Proteins 0.000 claims 1
- 102000007351 Interleukin-2 Receptor alpha Subunit Human genes 0.000 claims 1
- 108010032774 Interleukin-2 Receptor alpha Subunit Proteins 0.000 claims 1
- 102000008193 Interleukin-2 Receptor beta Subunit Human genes 0.000 claims 1
- 108010060632 Interleukin-2 Receptor beta Subunit Proteins 0.000 claims 1
- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102220234588 rs1114167484 Human genes 0.000 claims 1
- 102200032604 rs5030773 Human genes 0.000 claims 1
- 102220281620 rs551111938 Human genes 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426307P | 2010-12-22 | 2010-12-22 | |
| US61/426,307 | 2010-12-22 | ||
| PCT/US2011/066911 WO2012088446A1 (en) | 2010-12-22 | 2011-12-22 | Superagonists and antagonists of interleukin-2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199322A Division JP6441867B2 (ja) | 2010-12-22 | 2016-10-07 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502967A JP2014502967A (ja) | 2014-02-06 |
| JP2014502967A5 true JP2014502967A5 (enExample) | 2017-01-05 |
| JP6093712B2 JP6093712B2 (ja) | 2017-03-08 |
Family
ID=46314487
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546430A Active JP6093712B2 (ja) | 2010-12-22 | 2011-12-22 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
| JP2016199322A Active JP6441867B2 (ja) | 2010-12-22 | 2016-10-07 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199322A Active JP6441867B2 (ja) | 2010-12-22 | 2016-10-07 | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US9428567B2 (enExample) |
| EP (2) | EP2655409A4 (enExample) |
| JP (2) | JP6093712B2 (enExample) |
| CA (1) | CA2860170C (enExample) |
| WO (1) | WO2012088446A1 (enExample) |
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2011
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- 2011-12-22 EP EP11851134.4A patent/EP2655409A4/en not_active Withdrawn
- 2011-12-22 WO PCT/US2011/066911 patent/WO2012088446A1/en not_active Ceased
- 2011-12-22 EP EP16205861.4A patent/EP3211001B1/en active Active
- 2011-12-22 US US13/997,503 patent/US9428567B2/en active Active
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2016
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2018
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