CN112105633A - 新型白介素2及其用途 - Google Patents

新型白介素2及其用途 Download PDF

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CN112105633A
CN112105633A CN201980029369.6A CN201980029369A CN112105633A CN 112105633 A CN112105633 A CN 112105633A CN 201980029369 A CN201980029369 A CN 201980029369A CN 112105633 A CN112105633 A CN 112105633A
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mutein
mutation
mutations
cells
receptor
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CN112105633B (zh
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康立山
顾春银
付凤根
周帅祥
史新震
刘军建
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Innovent Biologics Suzhou Co Ltd
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Innovent Biologics Suzhou Co Ltd
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Abstract

本发明涉及新型白介素2(IL‑2)突变蛋白及其用途。具体地，本发明涉及，与野生型IL‑2相比，具有降低的IL‑2Rα受体结合能力和/或提高的IL‑2Rβ受体结合能力的IL‑2突变蛋白。本发明还提供包含该IL‑2突变蛋白的融合蛋白、免疫缀合物，以及编码该IL‑2突变蛋白的核酸、包含该核酸的载体和宿主细胞。本发明进一步提供制备该IL‑2突变蛋白的方法、包含该IL‑2突变蛋白的药物组合物和该突变蛋白的治疗用途。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201980029369.6A 2018-09-21 2019-09-20 新型白介素2及其用途 Active CN112105633B (zh)

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CN201811108649X 2018-09-21
PCT/CN2019/107055 WO2020057646A1 (zh) 2018-09-21 2019-09-20 新型白介素2及其用途

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WO2023005680A1 (zh) * 2021-07-30 2023-02-02 西安龙腾景云生物科技有限公司 一种人白细胞介素2变体及其用途

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US11692020B2 (en) 2019-11-20 2023-07-04 Anwita Biosciences, Inc. Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications
CA3162406A1 (en) 2020-01-10 2021-07-15 Vijaya Raghavan PATTABIRAMAN Modified il-2 polypeptides and uses thereof
EP4122951A4 (en) * 2020-03-19 2024-05-29 Innovent Biologics (Singapore) Pte. Ltd. INTERLEUKIN-2 MUTANT AND ITS USE
KR102545250B1 (ko) * 2020-03-31 2023-06-21 한미약품 주식회사 신규한 면역 활성 인터루킨 2 아날로그
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
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KR20230019889A (ko) * 2020-06-03 2023-02-09 아센디스 파마 온콜로지 디비전 에이/에스 Il-2 서열 및 이의 용도
WO2022050401A2 (en) * 2020-09-01 2022-03-10 Takeda Pharmaceutical Company Limited Interleukin-2 muteins and uses thereof
TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
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