JP2014502276A5 - - Google Patents
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- Publication number
- JP2014502276A5 JP2014502276A5 JP2013542218A JP2013542218A JP2014502276A5 JP 2014502276 A5 JP2014502276 A5 JP 2014502276A5 JP 2013542218 A JP2013542218 A JP 2013542218A JP 2013542218 A JP2013542218 A JP 2013542218A JP 2014502276 A5 JP2014502276 A5 JP 2014502276A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- apoe
- amino acid
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 7
- 102000013918 Apolipoproteins E Human genes 0.000 claims 5
- 108010025628 Apolipoproteins E Proteins 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 3
- 208000037259 Amyloid Plaque Diseases 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 230000010483 emotional dysregulation Effects 0.000 claims 1
- 210000001320 hippocampus Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41906010P | 2010-12-02 | 2010-12-02 | |
| US61/419,060 | 2010-12-02 | ||
| US201161548542P | 2011-10-18 | 2011-10-18 | |
| US61/548,542 | 2011-10-18 | ||
| PCT/US2011/063121 WO2012075422A2 (en) | 2010-12-02 | 2011-12-02 | Compositions and methods for treating amyloid plaque associated symptoms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014502276A JP2014502276A (ja) | 2014-01-30 |
| JP2014502276A5 true JP2014502276A5 (enExample) | 2015-01-22 |
Family
ID=46172597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013542218A Pending JP2014502276A (ja) | 2010-12-02 | 2011-12-02 | アミロイドプラーク関連症状の治療のための組成物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20140037638A1 (enExample) |
| EP (1) | EP2646053A4 (enExample) |
| JP (1) | JP2014502276A (enExample) |
| KR (1) | KR20140017513A (enExample) |
| CN (1) | CN103338786A (enExample) |
| AU (1) | AU2011336360A1 (enExample) |
| BR (1) | BR112013013723A2 (enExample) |
| CA (1) | CA2819679A1 (enExample) |
| MX (1) | MX2013006116A (enExample) |
| NZ (1) | NZ611614A (enExample) |
| RU (1) | RU2013130002A (enExample) |
| SG (1) | SG190952A1 (enExample) |
| WO (1) | WO2012075422A2 (enExample) |
| ZA (1) | ZA201303996B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013168174A1 (en) * | 2012-05-08 | 2013-11-14 | Ramot At Tel-Aviv University Ltd. | Apoe4 antibodies for treatment of neurodegenerative conditions |
| EP3760235A1 (en) | 2014-09-30 | 2021-01-06 | Washington University | Tau kinetic measurements |
| WO2017192711A1 (en) * | 2016-05-03 | 2017-11-09 | University Of South Florida | Compositions and methods of modulating abeta protein |
| US11124562B2 (en) | 2016-10-28 | 2021-09-21 | Washington University | Anti-ApoE antibodies |
| MA49652A (fr) | 2017-07-17 | 2020-05-27 | Janssen Biotech Inc | Régions de liaison à un antigène dirigées contre les domaines de la fibronectine de type iii et leurs procédés d'utilisation |
| AU2020282792B2 (en) * | 2019-05-28 | 2025-12-04 | Banner Health | ApoE antibodies, fusion proteins and uses thereof |
| WO2023069892A1 (en) * | 2021-10-19 | 2023-04-27 | Short Jay M | Conditionally active proteins for neurodegenerative diseases |
| EP4626925A1 (en) * | 2022-11-30 | 2025-10-08 | Regents of the University of Minnesota | Natural killer cell engagers |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994009155A1 (en) * | 1992-10-13 | 1994-04-28 | Duke University | Methods of detecting alzheimer's disease |
| EP2343318A3 (en) * | 2003-11-28 | 2013-02-27 | MedImmune Limited | Antibodies binding to a C-terminal fragment of apolipoprotein E |
| JPWO2005094846A1 (ja) * | 2004-03-30 | 2008-02-14 | 株式会社レノメディクス研究所 | プリオン病治療剤およびその製造方法 |
| JP2009531299A (ja) * | 2006-02-21 | 2009-09-03 | オクラホマ メディカル リサーチ ファウンデーション | ＡｐｏＥ受容体へのＡｐｏＥの結合のインヒビターによるアルツハイマー病の処置 |
| WO2008072723A1 (ja) * | 2006-12-14 | 2008-06-19 | Forerunner Pharma Research Co., Ltd. | 抗Claudin3モノクローナル抗体およびそれを用いる癌の治療および診断 |
| CL2008002775A1 (es) * | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
| WO2011109246A1 (en) * | 2010-03-01 | 2011-09-09 | The J. David Gladstone Institutes | Antibody specific for apolipoprotein and methods of use thereof |
-
2011
- 2011-12-02 WO PCT/US2011/063121 patent/WO2012075422A2/en not_active Ceased
- 2011-12-02 CN CN2011800667946A patent/CN103338786A/zh active Pending
- 2011-12-02 JP JP2013542218A patent/JP2014502276A/ja active Pending
- 2011-12-02 NZ NZ611614A patent/NZ611614A/en not_active IP Right Cessation
- 2011-12-02 US US13/990,777 patent/US20140037638A1/en not_active Abandoned
- 2011-12-02 EP EP11844128.6A patent/EP2646053A4/en not_active Withdrawn
- 2011-12-02 MX MX2013006116A patent/MX2013006116A/es not_active Application Discontinuation
- 2011-12-02 BR BR112013013723A patent/BR112013013723A2/pt not_active IP Right Cessation
- 2011-12-02 RU RU2013130002/10A patent/RU2013130002A/ru not_active Application Discontinuation
- 2011-12-02 SG SG2013042288A patent/SG190952A1/en unknown
- 2011-12-02 KR KR1020137016719A patent/KR20140017513A/ko not_active Withdrawn
- 2011-12-02 CA CA2819679A patent/CA2819679A1/en not_active Abandoned
- 2011-12-02 AU AU2011336360A patent/AU2011336360A1/en not_active Abandoned
-
2013
- 2013-05-31 ZA ZA2013/03996A patent/ZA201303996B/en unknown
-
2016
- 2016-08-22 US US15/243,495 patent/US20160355581A1/en not_active Abandoned