JP2014166995A - 点鼻用組成物 - Google Patents
点鼻用組成物 Download PDFInfo
- Publication number
- JP2014166995A JP2014166995A JP2014019412A JP2014019412A JP2014166995A JP 2014166995 A JP2014166995 A JP 2014166995A JP 2014019412 A JP2014019412 A JP 2014019412A JP 2014019412 A JP2014019412 A JP 2014019412A JP 2014166995 A JP2014166995 A JP 2014166995A
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- JP
- Japan
- Prior art keywords
- composition
- nasal
- salts
- acid
- dispersibility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 85
- 150000003839 salts Chemical class 0.000 claims abstract description 37
- 229920000642 polymer Polymers 0.000 claims abstract description 32
- 229930003658 monoterpene Natural products 0.000 claims abstract description 29
- 150000002773 monoterpene derivatives Chemical class 0.000 claims abstract description 29
- 235000002577 monoterpenes Nutrition 0.000 claims abstract description 29
- 229940092705 beclomethasone Drugs 0.000 claims abstract description 28
- ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960004958 ketotifen Drugs 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims description 39
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims description 26
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 25
- 229920002678 cellulose Polymers 0.000 claims description 22
- 239000001913 cellulose Substances 0.000 claims description 22
- 229960000265 cromoglicic acid Drugs 0.000 claims description 18
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims description 18
- 239000007923 nasal drop Substances 0.000 claims description 17
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- 239000000725 suspension Substances 0.000 claims description 11
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
- 229940041616 menthol Drugs 0.000 claims description 8
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- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 7
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- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 7
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 7
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 5
- 241000723346 Cinnamomum camphora Species 0.000 claims description 5
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 23
- -1 beclomethasone propionate ester Chemical class 0.000 abstract description 17
- 230000007774 longterm Effects 0.000 abstract description 4
- 229940109248 cromoglycate Drugs 0.000 abstract description 2
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 abstract description 2
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- 238000012360 testing method Methods 0.000 description 17
- 238000002156 mixing Methods 0.000 description 15
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 12
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- 230000000052 comparative effect Effects 0.000 description 12
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- 238000000034 method Methods 0.000 description 8
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 6
- 239000004327 boric acid Substances 0.000 description 6
- 235000010338 boric acid Nutrition 0.000 description 6
- 235000015165 citric acid Nutrition 0.000 description 6
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000008363 phosphate buffer Substances 0.000 description 5
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 239000006172 buffering agent Substances 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
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- 239000002826 coolant Substances 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 235000021317 phosphate Nutrition 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 3
- 239000006173 Good's buffer Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000007979 citrate buffer Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229940068968 polysorbate 80 Drugs 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 235000011083 sodium citrates Nutrition 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 2
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- ZFMSMUAANRJZFM-UHFFFAOYSA-N Estragole Chemical compound COC1=CC=C(CC=C)C=C1 ZFMSMUAANRJZFM-UHFFFAOYSA-N 0.000 description 2
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Abstract
【解決手段】(A)ベクロメタゾンプロピオン酸エステルと、(B)クロモグリク酸およびその塩類、ケトチフェン並びにその塩類からなる群より選ばれる少なくとも一種と、(C)0.001〜0.1w/v%のセルロース系高分子とを含有し、(D)モノテルペンを含有してもよいことを特徴とする点鼻用組成物(ただし、前記モノテルペン(D)を含有しない場合には、前記(B)成分1重量部に対して、前記セルロース系高分子(C)が0.0001〜0.05重量部含有される)。
【選択図】なし
Description
<1> (A)ベクロメタゾンプロピオン酸エステルと、
(B)クロモグリク酸およびその塩類、ケトチフェン並びにその塩類からなる群より選ばれる少なくとも一種と、
(C)0.001〜0.1w/v%のセルロース系高分子とを含有し、
(D)モノテルペンを含有してもよい
ことを特徴とする点鼻用組成物(ただし、前記モノテルペン(D)を含有しない場合には、前記(B)成分1重量部に対して、前記セルロース系高分子(C)が0.0001〜0.05重量部含有される)。
<(A)ベクロメタゾンプロピオン酸エステル>
ベクロメタゾンプロピオン酸エステル(A)は従来使用されているステロイド系抗炎症剤である。抗炎症作用について即効性はないものの持続性に優れているので、本発明の点鼻用組成物は一度の適用で効果が持続する。
本発明の点鼻用組成物はクロモグリク酸およびその塩類、ケトチフェン並びにその塩類からなる群より選ばれる少なくとも一種(B)を含有する。これらは従来広く使用されている抗アレルギー剤であるが、即効性に優れ、本発明の点鼻用組成物に良好な効果感を付与する。
本発明の点鼻用組成物は、0.001〜0.1w/v%のセルロース系高分子(C)を含有している。従来は難溶性成分であるベクロメタゾンプロピオン酸エステルを配合した点鼻薬について、多価アルコール、0.3〜3.5w/v%の結晶セルロース・カルメロースナトリウム、および清涼化剤を配合することで、ベクロメタゾンプロピオン酸エステルの良好な分散性を維持していた。
本発明の点鼻用組成物はモノテルペン(D)を含有していてもよい。
ベクロメタゾンプロピオン酸エステル(A)と(B)成分とを併用すると、特許文献1で採用されているような、所定量の結晶セルロースおよび清涼化剤を含有する組成においては、良好な分散性が達成されなくなる。
本発明の点鼻用組成物は、鼻腔粘膜に適用した場合に不快な刺激を生じにくくするためにpHを調整することができ、pHは通常4.0〜9.0、好ましくは4.0〜7.5、より好ましくは4.5〜7.0、特に好ましくは4.5〜6.5である。pH調整剤としては、ホウ酸、ホウ砂、リン酸、酢酸、プロピオン酸、シュウ酸、グルコン酸、フマル酸、乳酸、クエン酸、コハク酸、酒石酸、リンゴ酸、グルコノラクトン、酢酸アンモニウム、塩酸、硫酸、ポリリン酸、炭酸カリウム、炭酸水素ナトリウム、炭酸ナトリウム、炭酸水素アンモニウム、リン酸水素カリウム、乳酸ナトリウム、クエン酸ナトリウム、水酸化カリウム、水酸化ナトリウム、モノエタノールアミン、トリエタノールアミン、ジイソプロパノールアミン、トリイソプロパノールアミンなどが例示できる。
さらに、本発明の点鼻用組成物には、本発明の効果を妨げない範囲で、必要に応じて点鼻剤に用いられる有効成分、防腐剤、非イオン性界面活性剤、香料等を1種又は2種以上組み合わせて用いることができる。
本発明の点鼻用組成物は難溶性成分であるベクロメタゾンプロピオン酸エステルを含有しているため、通常界面活性剤(例えば上記非イオン性界面活性剤)を配合して懸濁製剤として用いられる。
本発明の点鼻用組成物は、スプレー式製剤、滴下式製剤、塗布式製剤等の種々の製剤形態をとることができる。また、前記スプレー式の製剤形態には、容器に付属されたポンプを手動で動かして液剤を噴出する機構のある手動ポンプ式点鼻剤、圧縮ガス(空気や酸素、窒素、炭酸や、混合ガス)等の噴射剤を容器内に充填しておいて容器に付属して設けた弁を動かして液剤を自動噴出する機構のあるエアゾール式点鼻剤なども含まれる。
本発明の点鼻用組成物は、その製剤形態に従い適切な方法で投与され、また例えば1回当たりの各鼻腔への投与量が、
ベクロメタゾンプロピオン酸エステル(A)が好ましくは1〜100μg、より好ましくは5〜50μg、さらに好ましくは10〜25μgとなるような量で、
また1日当たりの各鼻腔への投与量が、
ベクロメタゾンプロピオン酸エステル(A)が好ましくは10〜1000μg、より好ましくは50〜800μg、さらに好ましくは100〜400μgとなり、
(B)成分としてケトチフェン及び/又はその塩類を使用する場合にはその総量として好ましくは0.01〜15mg程度となり、
(B)成分としてクロモグリク酸及び/又はその塩類を使用する場合にはその総量として好ましくは0.01〜15mgとなるような量で、投与される。
本発明の点鼻用組成物の製造方法は特に制限されるものではなく、公知の方法によって前記組成物を製造することができる。例えば、以上説明した本発明における必須成分(A)〜(C)及び必要に応じて(D)成分やその他の成分等を、常法により水または温水中、必要に応じて油性基剤中に、溶解・懸濁させた後、pHや浸透圧などを適宜調整して液剤を製し、さらに必要に応じて無菌ろ過を行い、点鼻用容器に充填して製造することができる。
下記表1の組成に従って試験製剤1〜3を公知の方法により調製し、それぞれの分散性について評価した。具体的には以下の通り、各試験製剤の光照射前後における、分散性を確認することで評価を行った。なお、以下の表において数値の単位は、他に記載しない限り「w/v%」である。
試験開始時の分散性(%)=(分散後の濁度)/(製剤調製後の濁度)×100
光照射後の分散性(%)=(光照射後 分散後の濁度)/(光照射後の濁度)×100
下記表2の組成に従って実施例1〜4及び比較例1〜4の試験製剤を公知の方法により調製し、それぞれの試験開始時の分散性及び光照射後の分散性について、上記参考例と同様にして評価した。結果を下記表2に示す。
下記表3の組成に従って実施例5及び比較例5〜8の試験製剤を公知の方法により調製し、それぞれの試験開始時の分散性及び光照射後の分散性について、上記参考例と同様にして評価した。結果を下記表3に示す。
下記表4の組成に従って実施例6及び7並びに比較例9の試験製剤を公知の方法により調製し、それぞれの試験開始時の分散性について、上記参考例と同様にして評価した。結果を下記表4に示す。
下記の各成分を秤量したものに、精製水を全量で100mlとなるように加え、混合して懸濁液を調製(pH5.5)し、本発明の点鼻用組成物を得た。
プロピオン酸ベクロメタゾン 25mg(0.025w/v%)
クロモグリク酸ナトリウム 1000mg(1.0w/v%)
ヒドロキシプロピルメチルセルロース 1mg(0.001w/v%)
l-メントール 20mg(0.02w/v%)
ポリソルベート80 100mg(0.1w/v%)
プロピレングリコール 20000mg(20.0w/v%)
クエン酸 適量
クエン酸ナトリウム 適量
下記の各成分を秤量したものに、精製水を全量で100mlとなるように加え、混合し
て懸濁液を調製(pH5.8)し、本発明の点鼻用組成物を得た。
プロピオン酸ベクロメタゾン 50mg(0.05w/v%)
ケトチフェンフマル酸塩 75.6mg(0.0756w/v%)
ナファゾリン塩酸塩 25mg(0.025w/v%)
ヒドロキシプロピルメチルセルロース 1mg(0.001w/v%)
l-メントール 10mg(0.01w/v%)
ポリソルベート80 100mg(0.1w/v%)
プロピレングリコール 5000mg(5.0w/v%)
クエン酸 適量
クエン酸ナトリウム 適量
Claims (4)
- (A)ベクロメタゾンプロピオン酸エステルと、
(B)クロモグリク酸およびその塩類、ケトチフェン並びにその塩類からなる群より選ばれる少なくとも一種と、
(C)0.001〜0.1w/v%のセルロース系高分子とを含有し、
(D)モノテルペンを含有してもよい
ことを特徴とする点鼻用組成物(ただし、前記モノテルペン(D)を含有しない場合には、前記(B)成分1重量部に対して、前記セルロース系高分子(C)が0.0001〜0.05重量部含有される)。 - 前記セルロース系高分子(C)が、ヒドロキシプロピルメチルセルロース(HPMC)、ヒドロキシエチルセルロース(HEC)、ヒドロキシプロピルセルロース(HPC)、カルボキシメチルセルロース(CMC)及びその塩類、並びに結晶セルロースからなる群より選ばれる少なくとも一種であることを特徴とする請求項1に記載の点鼻用組成物。
- 前記点鼻用組成物が前記モノテルペン(D)を含有し、該モノテルペン(D)がメントール及び/又はカンフルであることを特徴とする請求項1又は2に記載の点鼻用組成物。
- 懸濁製剤であることを特徴とする、請求項1〜3のいずれかに記載の点鼻用組成物。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09328437A (ja) * | 1996-06-11 | 1997-12-22 | Taisho Pharmaceut Co Ltd | 鼻炎用点鼻薬 |
JPH101442A (ja) * | 1996-06-12 | 1998-01-06 | Taisho Pharmaceut Co Ltd | 鼻炎用点鼻薬 |
JP2004339213A (ja) * | 2003-04-25 | 2004-12-02 | Rohto Pharmaceut Co Ltd | 点鼻剤 |
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JP6279337B2 (ja) * | 2013-02-04 | 2018-02-14 | ロート製薬株式会社 | 点鼻用組成物 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH09328437A (ja) * | 1996-06-11 | 1997-12-22 | Taisho Pharmaceut Co Ltd | 鼻炎用点鼻薬 |
JPH101442A (ja) * | 1996-06-12 | 1998-01-06 | Taisho Pharmaceut Co Ltd | 鼻炎用点鼻薬 |
JP2004339213A (ja) * | 2003-04-25 | 2004-12-02 | Rohto Pharmaceut Co Ltd | 点鼻剤 |
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JP2018030889A (ja) * | 2013-02-04 | 2018-03-01 | ロート製薬株式会社 | 点鼻用組成物 |
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