JP2014110810A5 - - Google Patents
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- JP2014110810A5 JP2014110810A5 JP2014049395A JP2014049395A JP2014110810A5 JP 2014110810 A5 JP2014110810 A5 JP 2014110810A5 JP 2014049395 A JP2014049395 A JP 2014049395A JP 2014049395 A JP2014049395 A JP 2014049395A JP 2014110810 A5 JP2014110810 A5 JP 2014110810A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- antibody
- binding fragment
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims 33
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 150000001413 amino acids Chemical class 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 208000028867 ischemia Diseases 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 230000024203 complement activation Effects 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 208000030533 eye disease Diseases 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010002199 Anaphylactic shock Diseases 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 2
- 208000028185 Angioedema Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 206010013700 Drug hypersensitivity Diseases 0.000 claims 2
- 208000037487 Endotoxemia Diseases 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 2
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010021137 Hypovolaemia Diseases 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 208000034486 Multi-organ failure Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 206010040070 Septic Shock Diseases 0.000 claims 2
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 2
- 206010061372 Streptococcal infection Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 206010000891 acute myocardial infarction Diseases 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 208000003455 anaphylaxis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000002612 cardiopulmonary effect Effects 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 201000005311 drug allergy Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 238000001631 haemodialysis Methods 0.000 claims 2
- 230000000322 hemodialysis Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 230000010410 reperfusion Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000036303 septic shock Effects 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 208000007056 sickle cell anemia Diseases 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 102000003706 Complement factor D Human genes 0.000 claims 1
- 108090000059 Complement factor D Proteins 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85650506P | 2006-11-02 | 2006-11-02 | |
| US60/856,505 | 2006-11-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012235325A Division JP2013027404A (ja) | 2006-11-02 | 2012-10-25 | ヒト化抗ｄ因子抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015171685A Division JP2015214591A (ja) | 2006-11-02 | 2015-09-01 | ヒト化抗ｄ因子抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014110810A JP2014110810A (ja) | 2014-06-19 |
| JP2014110810A5 true JP2014110810A5 (OSRAM) | 2014-07-31 |
| JP5918794B2 JP5918794B2 (ja) | 2016-05-18 |
Family
ID=39345075
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535444A Withdrawn JP2010508819A (ja) | 2006-11-02 | 2007-10-31 | ヒト化抗ｄ因子抗体 |
| JP2012235325A Pending JP2013027404A (ja) | 2006-11-02 | 2012-10-25 | ヒト化抗ｄ因子抗体 |
| JP2012235324A Expired - Fee Related JP5474158B2 (ja) | 2006-11-02 | 2012-10-25 | ヒト化抗ｄ因子抗体 |
| JP2014049395A Active JP5918794B2 (ja) | 2006-11-02 | 2014-03-12 | ヒト化抗ｄ因子抗体 |
| JP2015171685A Withdrawn JP2015214591A (ja) | 2006-11-02 | 2015-09-01 | ヒト化抗ｄ因子抗体 |
| JP2017157499A Pending JP2017200492A (ja) | 2006-11-02 | 2017-08-17 | ヒト化抗ｄ因子抗体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535444A Withdrawn JP2010508819A (ja) | 2006-11-02 | 2007-10-31 | ヒト化抗ｄ因子抗体 |
| JP2012235325A Pending JP2013027404A (ja) | 2006-11-02 | 2012-10-25 | ヒト化抗ｄ因子抗体 |
| JP2012235324A Expired - Fee Related JP5474158B2 (ja) | 2006-11-02 | 2012-10-25 | ヒト化抗ｄ因子抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015171685A Withdrawn JP2015214591A (ja) | 2006-11-02 | 2015-09-01 | ヒト化抗ｄ因子抗体 |
| JP2017157499A Pending JP2017200492A (ja) | 2006-11-02 | 2017-08-17 | ヒト化抗ｄ因子抗体 |
Country Status (35)
| Country | Link |
|---|---|
| US (10) | US8067002B2 (OSRAM) |
| EP (4) | EP2907827B1 (OSRAM) |
| JP (6) | JP2010508819A (OSRAM) |
| KR (6) | KR20170110727A (OSRAM) |
| CN (7) | CN106188303A (OSRAM) |
| AR (2) | AR063760A1 (OSRAM) |
| AU (1) | AU2007313685C1 (OSRAM) |
| BR (1) | BRPI0716299A2 (OSRAM) |
| CA (2) | CA2667997C (OSRAM) |
| CL (1) | CL2007003161A1 (OSRAM) |
| CO (1) | CO6190543A2 (OSRAM) |
| CR (1) | CR10827A (OSRAM) |
| DK (2) | DK2907827T3 (OSRAM) |
| EC (1) | ECSP099379A (OSRAM) |
| ES (2) | ES2525477T3 (OSRAM) |
| HK (2) | HK1215712A1 (OSRAM) |
| HR (1) | HRP20181969T1 (OSRAM) |
| IL (3) | IL198512A (OSRAM) |
| LT (1) | LT2907827T (OSRAM) |
| MA (1) | MA30962B1 (OSRAM) |
| MX (1) | MX2009004665A (OSRAM) |
| MY (2) | MY183804A (OSRAM) |
| NO (1) | NO20092121L (OSRAM) |
| NZ (3) | NZ609813A (OSRAM) |
| PE (2) | PE20121034A1 (OSRAM) |
| PH (1) | PH12015501763A1 (OSRAM) |
| PL (2) | PL2907827T3 (OSRAM) |
| PT (2) | PT2907827T (OSRAM) |
| RS (1) | RS58233B1 (OSRAM) |
| RU (3) | RU2474589C9 (OSRAM) |
| SI (2) | SI2097455T1 (OSRAM) |
| TW (5) | TWI472535B (OSRAM) |
| UA (2) | UA101603C2 (OSRAM) |
| WO (1) | WO2008055206A2 (OSRAM) |
| ZA (2) | ZA200903088B (OSRAM) |
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| EP2026073B1 (en) * | 2000-04-29 | 2016-03-30 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| KR20180002911A (ko) | 2005-11-04 | 2018-01-08 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
| EP2826788B1 (en) | 2006-06-21 | 2017-12-13 | MUSC Foundation for Research Development | Targeting complement factor h for treatment of diseases by the use of cr2-fh molecules |
| AU2007313685C1 (en) | 2006-11-02 | 2015-09-17 | Genentech, Inc. | Humanized anti-Factor D antibodies |
| AR066660A1 (es) * | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| EP2899209A1 (en) * | 2008-04-29 | 2015-07-29 | Abbvie Inc. | Dual Variable Domain Immunoglobulins and uses thereof |
| EP2297208A4 (en) * | 2008-06-03 | 2012-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
| BRPI0913406A2 (pt) * | 2008-06-03 | 2018-01-09 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
| US8822645B2 (en) * | 2008-07-08 | 2014-09-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
| WO2010028028A1 (en) | 2008-09-08 | 2010-03-11 | Virginia Tech Intellectual Properties | Systems, devices, and methods for managing energy usage |
| BRPI1007371A2 (pt) * | 2009-01-29 | 2018-03-27 | Abbott Lab | proteínas de ligação a il-1 |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| KR20110020642A (ko) | 2009-08-24 | 2011-03-03 | 삼성전자주식회사 | 사용자 접근을 인식하여 반응하는 ｇｕｉ제공 장치 및 방법 |
| RU2012112550A (ru) * | 2009-09-01 | 2013-10-10 | Эбботт Лэборетриз | Иммуноглобулины с двумя вариабельными доменами и их применение |
| US8716450B2 (en) * | 2009-10-15 | 2014-05-06 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| UY32949A (es) * | 2009-10-15 | 2011-02-28 | Abbott Lab | Proteínas de unión a il-1 |
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| US20110165648A1 (en) | 2009-11-04 | 2011-07-07 | Menno Van Lookeren Campagne | Co-crystal structure of factor D and anti-factor D antibody |
| US10239937B2 (en) | 2009-11-05 | 2019-03-26 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
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