JP2014077003A5 - - Google Patents
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- Publication number
- JP2014077003A5 JP2014077003A5 JP2013257143A JP2013257143A JP2014077003A5 JP 2014077003 A5 JP2014077003 A5 JP 2014077003A5 JP 2013257143 A JP2013257143 A JP 2013257143A JP 2013257143 A JP2013257143 A JP 2013257143A JP 2014077003 A5 JP2014077003 A5 JP 2014077003A5
- Authority
- JP
- Japan
- Prior art keywords
- ischemia
- pharmaceutical composition
- final dose
- reperfusion injury
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 41
- 206010063837 Reperfusion injury Diseases 0.000 claims 25
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 13
- 208000028867 ischemia Diseases 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 238000000034 method Methods 0.000 claims 8
- 208000037906 ischaemic injury Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 206010022680 Intestinal ischaemia Diseases 0.000 claims 5
- 201000006474 Brain Ischemia Diseases 0.000 claims 4
- 238000001356 surgical procedure Methods 0.000 claims 4
- 208000031229 Cardiomyopathies Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 208000004535 Mesenteric Ischemia Diseases 0.000 claims 2
- 206010063897 Renal ischaemia Diseases 0.000 claims 2
- 210000003489 abdominal muscle Anatomy 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 206010009887 colitis Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 201000002818 limb ischemia Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 210000002027 skeletal muscle Anatomy 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000013875 Heart injury Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 238000007887 coronary angioplasty Methods 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/466,170 US7928067B2 (en) | 2009-05-14 | 2009-05-14 | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| US12/466,170 | 2009-05-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511009A Division JP5570590B2 (ja) | 2009-05-14 | 2010-05-13 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014077003A JP2014077003A (ja) | 2014-05-01 |
| JP2014077003A5 true JP2014077003A5 (cg-RX-API-DMAC7.html) | 2014-07-10 |
| JP5767307B2 JP5767307B2 (ja) | 2015-08-19 |
Family
ID=42244916
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511009A Active JP5570590B2 (ja) | 2009-05-14 | 2010-05-13 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
| JP2013257143A Active JP5767307B2 (ja) | 2009-05-14 | 2013-12-12 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511009A Active JP5570590B2 (ja) | 2009-05-14 | 2010-05-13 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7928067B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2429519B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5570590B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101636395B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102802622B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010249001B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1012182A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2761798C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2429519T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2470673T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL216349A (cg-RX-API-DMAC7.html) |
| MX (2) | MX2011012095A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ596364A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2429519T3 (cg-RX-API-DMAC7.html) |
| SG (1) | SG176062A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010132657A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8541396B2 (en) | 2009-04-24 | 2013-09-24 | National University Of Singapore | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent |
| US7928067B2 (en) * | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| WO2012067947A1 (en) * | 2010-11-18 | 2012-05-24 | Ischemix Llc | Lipoyl compounds and their use for treating ischemic injury |
| EP2540292A1 (en) * | 2011-06-28 | 2013-01-02 | Nestec S.A. | DHA and EPA in the reduction of oxidative stress |
| WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| EP2875826B1 (en) | 2012-05-11 | 2017-08-23 | KAEL-GemVax Co.,Ltd | Composition for preventing or treating sepsis |
| KR20150014483A (ko) | 2012-05-11 | 2015-02-06 | 주식회사 카엘젬백스 | 항염증 활성을 갖는 펩티드 및 이를 포함하는 조성물 |
| EP2873678B8 (en) | 2012-07-11 | 2024-07-17 | Gemvax & Kael Co., Ltd. | Conjugate comprising a cell-penetrating peptide and compositions comprising same |
| ES2716870T3 (es) | 2013-04-19 | 2019-06-17 | Gemvax & Kael Co Ltd | Composición para el tratamiento y prevención de lesión isquémica |
| CN105535931A (zh) | 2013-06-07 | 2016-05-04 | 凯尔杰姆维克斯有限公司 | 在癌症免疫疗法中有用的生物标记 |
| ES2808076T3 (es) | 2013-06-21 | 2021-02-25 | Gemvax & Kael Co Ltd | Regulador de la secreción hormonal, composición que lo contiene y procedimiento para controlar la secreción hormonal mediante su uso |
| BR112016008331B1 (pt) | 2013-10-23 | 2023-01-31 | Sang Jae Kim | Composição para tratar e prevenir hiperplasia prostática benigna (bhp) e uso da dita composição para tratar e prevenir bhp |
| WO2015076621A1 (ko) | 2013-11-22 | 2015-05-28 | 주식회사 카엘젬백스 | 혈관 신생 억제 활성을 가지는 펩티드 및 이를 포함하는 조성물 |
| US11058744B2 (en) | 2013-12-17 | 2021-07-13 | Gemvax & Kael Co., Ltd. | Composition for treating prostate cancer |
| JP6420459B2 (ja) | 2014-04-11 | 2018-11-07 | ジェムバックス アンド カエル カンパニー，リミティド | 線維症抑制活性を有するペプチド及びこれを含む組成物 |
| CN106659149B (zh) | 2014-04-30 | 2020-05-19 | 珍白斯凯尔有限公司 | 用于器官、组织或细胞移植的组合物、试剂盒和移植方法 |
| WO2015174948A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations comprising lipoyl compounds |
| CN104095835A (zh) * | 2014-06-20 | 2014-10-15 | 广州军区广州总医院 | 对羟基苄叉丙酮在制备预防和/或治疗肝缺血/再灌注损伤药物中的应用 |
| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
| EP3263122B1 (en) | 2015-02-27 | 2020-05-06 | Gemvax & Kael Co., Ltd. | Peptide for preventing hearing loss, and composition comprising same |
| WO2017003267A1 (ko) | 2015-07-02 | 2017-01-05 | 주식회사 젬백스앤카엘 | 항바이러스 활성 효능을 가지는 펩티드 및 이를 포함하는 조성물 |
| US10898540B2 (en) | 2016-04-07 | 2021-01-26 | Gem Vax & KAEL Co., Ltd. | Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same |
| CN106083800A (zh) * | 2016-06-13 | 2016-11-09 | 崔坤峰 | 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 |
| KR20190062502A (ko) * | 2016-10-05 | 2019-06-05 | 미토브리지, 인크. | 급성 신장 손상을 치료하는 방법 |
| CN110913851B (zh) | 2017-04-25 | 2023-08-25 | 伊斯切米克斯公司 | 治疗外伤性脑损伤的组合物和方法 |
| KR102139678B1 (ko) | 2017-11-24 | 2020-07-31 | 전북대학교 산학협력단 | N-아세틸 또는 n-아실 아미노산을 포함하는 아토피 또는 가려움증 치료용 조성물 |
| KR102112949B1 (ko) | 2019-02-12 | 2020-05-19 | 남현규 | 복합 효모 발효로 불용 단백질을 가용화하여 화장품원료를 추출하는 화장품원료 제조방법 |
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| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| US8080674B2 (en) | 2009-06-12 | 2011-12-20 | Ampac Fine Chemicals Llc. | Preparation of polymer-free R-(+)-α-lipoic acid magnesium salt |
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| US20150329519A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations Comprising Lipoyl Compounds |
| WO2015174948A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations comprising lipoyl compounds |
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2009
- 2009-05-14 US US12/466,170 patent/US7928067B2/en active Active
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2010
- 2010-05-13 EP EP10720092.5A patent/EP2429519B1/en active Active
- 2010-05-13 PL PL10720092T patent/PL2429519T3/pl unknown
- 2010-05-13 CA CA2761798A patent/CA2761798C/en active Active
- 2010-05-13 BR BRPI1012182A patent/BRPI1012182A2/pt not_active Application Discontinuation
- 2010-05-13 JP JP2012511009A patent/JP5570590B2/ja active Active
- 2010-05-13 DK DK10720092.5T patent/DK2429519T3/da active
- 2010-05-13 US US13/319,839 patent/US8772250B2/en active Active
- 2010-05-13 SG SG2011083862A patent/SG176062A1/en unknown
- 2010-05-13 CN CN201080031479.5A patent/CN102802622B/zh active Active
- 2010-05-13 MX MX2011012095A patent/MX2011012095A/es active IP Right Grant
- 2010-05-13 KR KR1020117029417A patent/KR101636395B1/ko active Active
- 2010-05-13 WO PCT/US2010/034701 patent/WO2010132657A1/en not_active Ceased
- 2010-05-13 NZ NZ596364A patent/NZ596364A/xx not_active IP Right Cessation
- 2010-05-13 MX MX2013004034A patent/MX347460B/es unknown
- 2010-05-13 ES ES10720092.5T patent/ES2470673T3/es active Active
- 2010-05-13 AU AU2010249001A patent/AU2010249001B2/en not_active Ceased
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2011
- 2011-03-04 US US13/041,001 patent/US8772249B2/en active Active
- 2011-11-14 IL IL216349A patent/IL216349A/en active IP Right Grant
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2013
- 2013-12-12 JP JP2013257143A patent/JP5767307B2/ja active Active
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2014
- 2014-05-21 US US14/283,844 patent/US20140274917A1/en not_active Abandoned
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2015
- 2015-03-19 IL IL237820A patent/IL237820A/en active IP Right Grant
- 2015-10-20 US US14/918,175 patent/US9540417B2/en active Active