JP2014074012A5 - - Google Patents
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- Publication number
- JP2014074012A5 JP2014074012A5 JP2013176862A JP2013176862A JP2014074012A5 JP 2014074012 A5 JP2014074012 A5 JP 2014074012A5 JP 2013176862 A JP2013176862 A JP 2013176862A JP 2013176862 A JP2013176862 A JP 2013176862A JP 2014074012 A5 JP2014074012 A5 JP 2014074012A5
- Authority
- JP
- Japan
- Prior art keywords
- derivatives
- salts
- alcohol
- pyrrolidone
- poe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 10
- -1 aromatic carboxylic acids Chemical class 0.000 claims 8
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 8
- YTAOBBFIOAEMLL-REQDGWNSSA-N Luliconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@H](CS\1)SC/1=C(\C#N)N1C=NC=C1 YTAOBBFIOAEMLL-REQDGWNSSA-N 0.000 claims 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 229960000570 luliconazole Drugs 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 150000005846 sugar alcohols Polymers 0.000 claims 6
- 238000003860 storage Methods 0.000 claims 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical group CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 4
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 239000000739 antihistaminic agent Substances 0.000 claims 4
- 150000002576 ketones Chemical class 0.000 claims 4
- 239000003589 local anesthetic agent Substances 0.000 claims 4
- 239000002736 nonionic surfactant Substances 0.000 claims 4
- 235000011007 phosphoric acid Nutrition 0.000 claims 4
- BAERPNBPLZWCES-UHFFFAOYSA-N (2-hydroxy-1-phosphonoethyl)phosphonic acid Chemical class OCC(P(O)(O)=O)P(O)(O)=O BAERPNBPLZWCES-UHFFFAOYSA-N 0.000 claims 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 3
- 229940125715 antihistaminic agent Drugs 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Chemical group 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229960005015 local anesthetics Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940055577 oleyl alcohol Drugs 0.000 claims 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Chemical group 0.000 claims 2
- 229920001451 polypropylene glycol Chemical group 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 claims 1
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 claims 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 229960000520 diphenhydramine Drugs 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 229960002389 glycol salicylate Drugs 0.000 claims 1
- 150000001261 hydroxy acids Chemical class 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 150000003007 phosphonic acid derivatives Chemical class 0.000 claims 1
- 150000003016 phosphoric acids Chemical class 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 0 *C([n]1cncc1)=C(SC1)SC1C(CCC(Cl)=C1)=C1Cl Chemical compound *C([n]1cncc1)=C(SC1)SC1C(CCC(Cl)=C1)=C1Cl 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013176862A JP5686874B2 (ja) | 2012-09-14 | 2013-08-28 | 医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012203293 | 2012-09-14 | ||
| JP2012203293 | 2012-09-14 | ||
| JP2013176862A JP5686874B2 (ja) | 2012-09-14 | 2013-08-28 | 医薬組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014056829A Division JP6215102B2 (ja) | 2012-09-14 | 2014-03-19 | 医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014074012A JP2014074012A (ja) | 2014-04-24 |
| JP2014074012A5 true JP2014074012A5 (enExample) | 2014-06-05 |
| JP5686874B2 JP5686874B2 (ja) | 2015-03-18 |
Family
ID=49226452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013176862A Expired - Fee Related JP5686874B2 (ja) | 2012-09-14 | 2013-08-28 | 医薬組成物 |
| JP2014056829A Expired - Fee Related JP6215102B2 (ja) | 2012-09-14 | 2014-03-19 | 医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014056829A Expired - Fee Related JP6215102B2 (ja) | 2012-09-14 | 2014-03-19 | 医薬組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150238606A1 (enExample) |
| EP (1) | EP2895164A1 (enExample) |
| JP (2) | JP5686874B2 (enExample) |
| CN (1) | CN104619320A (enExample) |
| IN (1) | IN2015DN02377A (enExample) |
| RU (1) | RU2621615C2 (enExample) |
| WO (1) | WO2014042043A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2416758B8 (en) | 2009-04-09 | 2017-10-18 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| US10130610B2 (en) | 2009-04-09 | 2018-11-20 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| US8952044B2 (en) | 2009-08-25 | 2015-02-10 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| EP2579847A1 (en) | 2010-06-11 | 2013-04-17 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| JP6265624B2 (ja) * | 2012-05-11 | 2018-01-24 | ロート製薬株式会社 | ルリコナゾール含有外用医薬組成物 |
| CN104619703A (zh) | 2012-09-14 | 2015-05-13 | 宝丽制药股份有限公司 | 具有结晶习性的晶体以及通过对所述晶体进行加工获得的药物组合物 |
| JP5460797B1 (ja) * | 2012-09-14 | 2014-04-02 | 株式会社ポーラファルマ | アミド誘導体及び安定性指標としてのその使用 |
| IN2015DN02929A (enExample) | 2012-09-14 | 2015-09-18 | Pola Pharma Inc | |
| WO2014041846A1 (en) | 2012-09-14 | 2014-03-20 | Pola Pharma Inc. | Use of surface free energy for differential evaluation of crystal, crystal evaluated on basis of surface free energy as index, and phrmaceutical composition prepared by containing the crystal |
| JP5589110B1 (ja) | 2013-03-08 | 2014-09-10 | 株式会社ポーラファルマ | 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物 |
| JP6503627B2 (ja) * | 2013-03-28 | 2019-04-24 | 大正製薬株式会社 | 医薬液体組成物 |
| JP5680161B1 (ja) | 2013-09-06 | 2015-03-04 | 株式会社ポーラファルマ | 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物 |
| JP6242655B2 (ja) * | 2013-10-29 | 2017-12-06 | リンテック株式会社 | 機能性物質の放出方法、機能性物質の放出用キット及び放出性組成物 |
| JP5587488B1 (ja) | 2013-12-12 | 2014-09-10 | 株式会社ポーラファルマ | ルリコナゾールを含有する製剤の評価方法及び指標物質 |
| WO2017203456A1 (en) * | 2016-05-25 | 2017-11-30 | Glenmark Pharmaceuticals Limited | Luliconazole stable topicalcompositions |
| CN107865825B (zh) * | 2016-09-28 | 2022-05-20 | 四川海思科制药有限公司 | 一种卢立康唑外用喷雾剂药物组合物及其制备方法 |
| WO2018179170A1 (ja) * | 2017-03-29 | 2018-10-04 | 日本農薬株式会社 | 感染症を治療するための医薬組成物 |
| SG11202003820VA (en) * | 2017-10-30 | 2020-05-28 | Kaken Pharmaceutical Co Ltd | External preparation for treating trichophytosis unguium |
| CN108143711A (zh) * | 2018-01-13 | 2018-06-12 | 天津双硕医药科技有限公司 | 一种含有卢立康唑的外用乳膏组合物 |
| US10898470B1 (en) * | 2019-08-13 | 2021-01-26 | Sato Pharmaceutical Co., Ltd. | Pharmaceutical composition containing antifungal agent as active ingredient |
| CN113774390B (zh) * | 2021-08-12 | 2023-08-04 | 上海新阳半导体材料股份有限公司 | 一种用于化学机械抛光后的清洗液及其制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006339842B2 (en) * | 2006-03-08 | 2012-06-07 | Nihon Nohyaku Co., Ltd. | Pharmaceutical composition for external use |
| WO2007102243A1 (ja) | 2006-03-08 | 2007-09-13 | Nihon Nohyaku Co., Ltd. | 外用の医薬組成物 |
| JP5184341B2 (ja) | 2006-03-08 | 2013-04-17 | 日本農薬株式会社 | 外用の医薬組成物 |
| US8492421B2 (en) * | 2007-08-27 | 2013-07-23 | Nihon Nohyaku Co., Ltd. | Agent for fungal dermatitis |
| WO2009031642A1 (ja) * | 2007-09-05 | 2009-03-12 | Pola Pharma Inc. | 医薬組成物 |
| EP2191828B1 (en) | 2007-09-05 | 2016-08-10 | Pola Pharma Inc. | Antifungal pharmaceutical composition |
| JP5345937B2 (ja) * | 2007-09-05 | 2013-11-20 | 株式会社ポーラファルマ | 抗真菌組成物 |
| US20090130232A1 (en) * | 2007-11-20 | 2009-05-21 | Mohammed Zahra | Composition and method for treatment of oral inflammation an ulceration |
| US8445717B2 (en) * | 2008-11-20 | 2013-05-21 | Chd Bioscience, Inc. | α-Keto alkylperacids and methods for producing and using the same |
| EP2395839B1 (en) * | 2009-02-13 | 2014-05-07 | Topica Pharmaceuticals, Inc | Anti-fungal formulation |
| EP2416758B8 (en) * | 2009-04-09 | 2017-10-18 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| US10130610B2 (en) * | 2009-04-09 | 2018-11-20 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| US8952044B2 (en) * | 2009-08-25 | 2015-02-10 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| EP2579847A1 (en) * | 2010-06-11 | 2013-04-17 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
| EP2675441A4 (en) * | 2011-02-17 | 2014-12-31 | Chd Bioscience Inc | COMPOSITIONS WITH PEROXY-ALPHA-KETOCARBOXYLIC ACID AND METHOD FOR THE PRODUCTION AND THEIR USE |
-
2013
- 2013-08-28 RU RU2015108930A patent/RU2621615C2/ru not_active IP Right Cessation
- 2013-08-28 WO PCT/JP2013/073731 patent/WO2014042043A1/en not_active Ceased
- 2013-08-28 CN CN201380047768.8A patent/CN104619320A/zh active Pending
- 2013-08-28 EP EP13765810.0A patent/EP2895164A1/en not_active Ceased
- 2013-08-28 JP JP2013176862A patent/JP5686874B2/ja not_active Expired - Fee Related
- 2013-08-28 US US14/427,890 patent/US20150238606A1/en not_active Abandoned
- 2013-08-28 IN IN2377DEN2015 patent/IN2015DN02377A/en unknown
-
2014
- 2014-03-19 JP JP2014056829A patent/JP6215102B2/ja not_active Expired - Fee Related