JP2014043462A5 - - Google Patents
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- Publication number
- JP2014043462A5 JP2014043462A5 JP2013244692A JP2013244692A JP2014043462A5 JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5 JP 2013244692 A JP2013244692 A JP 2013244692A JP 2013244692 A JP2013244692 A JP 2013244692A JP 2014043462 A5 JP2014043462 A5 JP 2014043462A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- amino
- nucleic acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- -1 2-oxo-1,2-dihydropyrimidin-1-yl group Chemical group 0.000 claims 22
- 238000001668 nucleic acid synthesis Methods 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000003277 amino group Chemical group 0.000 claims 8
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009248979 | 2009-10-29 | ||
| JP2009248979 | 2009-10-29 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2010023209 | 2010-02-04 | ||
| JP2013244692A JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Division JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014043462A JP2014043462A (ja) | 2014-03-13 |
| JP2014043462A5 true JP2014043462A5 (cg-RX-API-DMAC7.html) | 2014-05-29 |
| JP5669073B2 JP5669073B2 (ja) | 2015-02-12 |
Family
ID=43921860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
| JP2013244692A Active JP5669073B2 (ja) | 2009-10-29 | 2013-11-27 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538366A Ceased JPWO2011052436A1 (ja) | 2009-10-29 | 2010-10-19 | 架橋型人工ヌクレオシドおよびヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8541562B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2495248B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JPWO2011052436A1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102596983B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010312751B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2778171C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011052436A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012029870A1 (ja) * | 2010-08-31 | 2012-03-08 | 国立大学法人大阪大学 | オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤 |
| US20140323709A1 (en) | 2011-12-12 | 2014-10-30 | National Cerebral And Cardiovascular Center | Oligonucleotide and therapeutic agent for hyperlipidemia containing same as active ingredient |
| TW201402594A (zh) | 2012-06-18 | 2014-01-16 | Daiichi Sankyo Co Ltd | 核苷類似物的製造中間體及其製造方法 |
| CA2885719C (en) * | 2012-09-21 | 2017-07-11 | Osaka University | Oligonucleotide and artificial nucleoside having guanidine bridge |
| WO2014109384A1 (ja) * | 2013-01-10 | 2014-07-17 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
| JPWO2014112463A1 (ja) * | 2013-01-15 | 2017-01-19 | 国立大学法人大阪大学 | スルホンアミド構造を有するヌクレオシドおよびヌクレオチド |
| WO2014126229A1 (ja) | 2013-02-18 | 2014-08-21 | 塩野義製薬株式会社 | 含窒素複素環構造を有するヌクレオシド及びヌクレオチド |
| WO2015020194A1 (ja) * | 2013-08-09 | 2015-02-12 | 国立大学法人大阪大学 | Ａｃｓｌ１に対するアンチセンスオリゴヌクレオチド |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| US20170211073A1 (en) * | 2014-07-10 | 2017-07-27 | Kenji Nakano | Antisense antineoplastic agent |
| KR102620328B1 (ko) | 2014-10-03 | 2024-01-02 | 콜드스프링하버러보러토리 | 핵 유전자 산출량의 표적화 증강 |
| JP2018140938A (ja) * | 2015-07-24 | 2018-09-13 | 日産化学株式会社 | 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| KR20220105174A (ko) | 2015-10-09 | 2022-07-26 | 유니버시티 오브 사우스앰톤 | 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 |
| CN109312343B (zh) | 2015-12-14 | 2022-09-27 | 冷泉港实验室 | 用于治疗常染色体显性精神发育迟滞5型和Dravet综合征的反义寡聚体 |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| EP3415524A4 (en) * | 2016-01-07 | 2019-09-04 | Osaka University | INHIBITOR OF α-SYNNUCLEINE EXPRESSION |
| AU2017211461B2 (en) | 2016-01-26 | 2023-01-12 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| EP3418289A4 (en) | 2016-02-17 | 2019-10-30 | Tokyo Institute of Technology | ARTIFICIAL NUCLEOSIDE AND ARTIFICIAL NUCLEOTIDE AND ARTIFICIAL OLIGONUCLEOTIDE |
| WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| JP2020055750A (ja) * | 2017-01-30 | 2020-04-09 | 賢二 中野 | 癌浸潤または転移阻害核酸薬 |
| CA3052801A1 (en) | 2017-02-06 | 2018-08-09 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| WO2018155450A1 (ja) | 2017-02-21 | 2018-08-30 | 国立大学法人大阪大学 | アンチセンスオリゴ核酸 |
| JP7138349B2 (ja) * | 2017-02-21 | 2022-09-16 | 国立大学法人大阪大学 | 核酸化合物およびオリゴヌクレオチド |
| US11638717B2 (en) | 2017-03-29 | 2023-05-02 | Shionogi & Co., Ltd. | Complex of nucleic acid medicine and multibranched lipid |
| JP7141621B2 (ja) | 2017-03-31 | 2022-09-26 | 学校法人 愛知医科大学 | コンドロイチン硫酸生合成を阻害するアンチセンス核酸 |
| EP3633036A4 (en) | 2017-05-26 | 2021-03-17 | National Cerebral and Cardiovascular Center | NUCLEIC ACID TARGETING ANTI-SENSES PCSK9 |
| EP3628737A4 (en) | 2017-07-05 | 2021-01-20 | Osaka University | ENA-ANTISENSE-OLIGONUCLEOTIDE TO INHIBIT ALPHA-SYNUCLEIN EXPRESSION |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| AU2018307294B2 (en) | 2017-07-26 | 2025-04-17 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| SMT202400071T1 (it) | 2017-08-25 | 2024-03-13 | Stoke Therapeutics Inc | Oligomeri antisenso per il trattamento di condizioni e malattie |
| JP7177446B2 (ja) | 2017-08-31 | 2022-11-24 | 田辺三菱製薬株式会社 | Ｉｌ－３３アンタゴニストを含む子宮内膜症治療剤 |
| AU2019237599A1 (en) | 2018-03-20 | 2020-11-12 | Nissan Chemical Corporation | Antisense oligonucleotide having reduced toxicity |
| US12060558B2 (en) | 2018-05-04 | 2024-08-13 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| CN112513062B (zh) * | 2018-07-31 | 2024-05-10 | 国立大学法人大阪大学 | 含有寡聚核苷酸的小细胞肺癌治疗药 |
| EP3967328A4 (en) | 2019-03-29 | 2022-12-28 | Sysmex Corporation | NEW ARTIFICIAL NUCLEIC ACID, METHOD FOR MAKING IT, AND USE THEREOF |
| SG11202112741XA (en) | 2019-05-31 | 2021-12-30 | Aligos Therapeutics Inc | Modified gapmer oligonucleotides and methods of use |
| EP4005602A4 (en) | 2019-07-30 | 2024-06-12 | Shionogi & Co., Ltd | NUCLEIC ACID AGENT TARGETED AGAINST MURF1 |
| WO2021039879A1 (ja) | 2019-08-27 | 2021-03-04 | 国立大学法人東海国立大学機構 | 胃癌分子標的核酸医薬 |
| WO2021127406A1 (en) * | 2019-12-19 | 2021-06-24 | The Regents Of The University Of California | Methods of producing target capture nucleic acids |
| WO2021132648A1 (ja) * | 2019-12-27 | 2021-07-01 | ルクサナバイオテク株式会社 | Ｒｅｃｑｌの発現を阻害するアンチセンスオリゴヌクレオチド及びその用途 |
| WO2021177267A1 (ja) | 2020-03-02 | 2021-09-10 | 田辺三菱製薬株式会社 | ｍｉＲ－３３ｂ阻害物質による動脈瘤の予防または治療 |
| CN115485381A (zh) | 2020-03-26 | 2022-12-16 | 国立研究开发法人国立循环器病研究中心 | 以apoc3为靶点的反义核酸 |
| WO2021216785A1 (en) | 2020-04-21 | 2021-10-28 | Flagship Pioneering, Inc. | Bifunctional molecules and methods of using thereof |
| CA3173647A1 (en) | 2020-05-11 | 2021-11-18 | Isabel AZNAREZ | Opa1 antisense oligomers for treatment of conditions and diseases |
| EP4219517A4 (en) | 2020-09-25 | 2024-09-25 | Riken Genesis Co., Ltd. | NOVEL ARTIFICIAL NUCLEIC ACID, METHOD FOR PRODUCING THE SAME AND USE THEREOF |
| WO2022097727A1 (ja) | 2020-11-06 | 2022-05-12 | 住友ファーマ株式会社 | Ｒｐｓ２５遺伝子の発現及び／又は機能調節剤 |
| WO2022181807A1 (ja) | 2021-02-25 | 2022-09-01 | 国立大学法人大阪大学 | ＲＥＳＴ ｍＲＮＡ前駆体のプロセシングにおけるＮエキソンのスキッピングを誘導するオリゴヌクレオチド |
| EP4331606A4 (en) | 2021-04-30 | 2025-05-07 | Kyoto University | PREVENTION OR TREATMENT OF MYOPATHY USING A MIR-33B INHIBITOR |
| US20240247263A1 (en) | 2021-05-06 | 2024-07-25 | Luxna Biotech Co., Ltd. | Method for designing oligonucleotide having reduced central toxicity |
| KR20240013202A (ko) | 2021-05-28 | 2024-01-30 | 스미토모 파마 가부시키가이샤 | 안티센스 핵산 |
| EP4389893A4 (en) | 2021-08-21 | 2025-09-10 | Takeda Pharmaceuticals Co | PEPTIDE-DRUG CONJUGATE BINDING HUMAN TRANSFERRIN RECEPTOR |
| JPWO2023127857A1 (cg-RX-API-DMAC7.html) | 2021-12-27 | 2023-07-06 | ||
| EP4495242A1 (en) | 2022-03-17 | 2025-01-22 | Aichi Medical University | Antisense nucleic acid capable of inhibiting biosynthesis of chondroitin sulfate |
| CN120187739A (zh) | 2022-11-10 | 2025-06-20 | 璐库萨那生物技术株式会社 | 桥联部具有胍基结构的修饰核苷和使用其的寡核苷酸的制造方法 |
| JPWO2024181416A1 (cg-RX-API-DMAC7.html) | 2023-02-28 | 2024-09-06 | ||
| WO2024257847A1 (ja) | 2023-06-16 | 2024-12-19 | 住友ファーマ株式会社 | Ｒｐｓ２５遺伝子の発現及び／又はその機能を調節するアンチセンスオリゴヌクレオチド |
| WO2025005265A1 (ja) * | 2023-06-30 | 2025-01-02 | 日産化学株式会社 | 毒性が低減されたアンチセンスオリゴヌクレオチド |
| US20250368996A1 (en) | 2024-05-14 | 2025-12-04 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| HRP20000751A2 (en) | 1998-05-26 | 2001-12-31 | Icn Pharmaceuticals | Novel nucleosides having bicyclic sugar moiety |
| US7615619B2 (en) | 2002-02-13 | 2009-11-10 | Takeshi Imanishi | Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof |
| US7427672B2 (en) | 2003-08-28 | 2008-09-23 | Takeshi Imanishi | Artificial nucleic acids of n-o bond crosslinkage type |
| WO2012029870A1 (ja) * | 2010-08-31 | 2012-03-08 | 国立大学法人大阪大学 | オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤 |
-
2010
- 2010-10-19 JP JP2011538366A patent/JPWO2011052436A1/ja not_active Ceased
- 2010-10-19 CA CA2778171A patent/CA2778171C/en active Active
- 2010-10-19 EP EP10826568.7A patent/EP2495248B1/en active Active
- 2010-10-19 WO PCT/JP2010/068409 patent/WO2011052436A1/ja not_active Ceased
- 2010-10-19 CN CN201080049279.2A patent/CN102596983B/zh active Active
- 2010-10-19 AU AU2010312751A patent/AU2010312751B2/en active Active
- 2010-10-19 US US13/502,611 patent/US8541562B2/en active Active
-
2013
- 2013-11-27 JP JP2013244692A patent/JP5669073B2/ja active Active
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