JP2013539967A5 - - Google Patents

Download PDF

Info

Publication number
JP2013539967A5
JP2013539967A5 JP2013528272A JP2013528272A JP2013539967A5 JP 2013539967 A5 JP2013539967 A5 JP 2013539967A5 JP 2013528272 A JP2013528272 A JP 2013528272A JP 2013528272 A JP2013528272 A JP 2013528272A JP 2013539967 A5 JP2013539967 A5 JP 2013539967A5
Authority
JP
Japan
Prior art keywords
antisense oligonucleotide
alkyl
modification
aryl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013528272A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013539967A (ja
JP6053684B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/050710 external-priority patent/WO2012033848A1/en
Publication of JP2013539967A publication Critical patent/JP2013539967A/ja
Publication of JP2013539967A5 publication Critical patent/JP2013539967A5/ja
Application granted granted Critical
Publication of JP6053684B2 publication Critical patent/JP6053684B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013528272A 2010-09-07 2011-09-07 アンチセンス化合物の修飾 Expired - Fee Related JP6053684B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38058610P 2010-09-07 2010-09-07
US61/380,586 2010-09-07
PCT/US2011/050710 WO2012033848A1 (en) 2010-09-07 2011-09-07 Modifications for antisense compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016233800A Division JP2017070299A (ja) 2010-09-07 2016-12-01 アンチセンス化合物の修飾

Publications (3)

Publication Number Publication Date
JP2013539967A JP2013539967A (ja) 2013-10-31
JP2013539967A5 true JP2013539967A5 (enExample) 2014-10-23
JP6053684B2 JP6053684B2 (ja) 2016-12-27

Family

ID=44674883

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013528272A Expired - Fee Related JP6053684B2 (ja) 2010-09-07 2011-09-07 アンチセンス化合物の修飾
JP2016233800A Pending JP2017070299A (ja) 2010-09-07 2016-12-01 アンチセンス化合物の修飾

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016233800A Pending JP2017070299A (ja) 2010-09-07 2016-12-01 アンチセンス化合物の修飾

Country Status (6)

Country Link
US (3) US20120108799A1 (enExample)
EP (2) EP2896696B1 (enExample)
JP (2) JP6053684B2 (enExample)
AU (1) AU2011299233B2 (enExample)
CA (1) CA2809457C (enExample)
WO (1) WO2012033848A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2809457C (en) 2010-09-07 2019-07-30 Integrated Dna Technologies, Inc. Modifications for antisense compounds
WO2014130945A1 (en) * 2013-02-25 2014-08-28 Integrated Dna Technologies, Inc. Modifications for antisense compounds
CN105008533A (zh) * 2013-03-01 2015-10-28 国立大学法人东京医科齿科大学 嵌合单链反义多核苷酸和双链反义试剂
TW201620526A (zh) * 2014-06-17 2016-06-16 愛羅海德研究公司 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法
MX2019008252A (es) 2017-01-10 2019-09-06 Arrowhead Pharmaceuticals Inc Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso.
CN117756946A (zh) 2017-11-03 2024-03-26 莱蒂恩技术公司 用于用抗ror1免疫治疗来治疗癌症的组合物和方法
AU2021244687A1 (en) * 2020-03-24 2022-11-10 Flagship Pioneering Innovations Vi, Llc Bifunctional molecules and methods of using thereof
AU2021261343A1 (en) 2020-04-22 2022-11-03 President And Fellows Of Harvard College Isothermal methods, compositions, kits, and systems for detecting nucleic acids
WO2023028085A2 (en) * 2021-08-23 2023-03-02 Cold Spring Harbor Laboratory Antisense oligonucleotide therapy for h3.3 k27m diffuse midline gliomas
JP2025541744A (ja) 2022-12-01 2025-12-23 ベクトン・ディキンソン・アンド・カンパニー 核酸検出のための非対称性ヘアピンプローブ

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2264303A (en) 1940-03-27 1941-12-02 Eastman Kodak Co Azo compounds and material colored therewith
US3407189A (en) 1956-07-25 1968-10-22 Sandoz Ltd Water-insoluble monoazo dyestuffs
US3218309A (en) 1961-08-14 1965-11-16 Parke Davis & Co Azo compounds
GB1394368A (en) 1972-12-14 1975-05-14 Ici Ltd Disperse azo dyestuffs
US3970617A (en) 1974-03-07 1976-07-20 E. I. Du Pont De Nemours And Company Navy-blue nitrophenylazonaphthylamino dyes
GB1533121A (en) 1975-08-04 1978-11-22 Ici Ltd Disperse nitro disazo dyestuffs
DE2546535A1 (de) 1975-10-17 1977-04-28 Bayer Ag Azofarbstoffe
JPS5288681A (en) 1976-01-12 1977-07-25 Mitsubishi Chem Ind Dyeing method of synthetic fibers
JPS5291031A (en) 1976-01-27 1977-08-01 Mitsubishi Chem Ind Ltd Production of monoazo dye
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4439356A (en) 1981-03-03 1984-03-27 Syva Company Unsymmetrical fluorescein derivatives
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1190838A (en) 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1180647A (en) 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1185177A (en) 1981-07-17 1985-04-09 Larry E. Morrison Non-radiative energy transfer immunochemical technique
FR2540122B1 (fr) 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
CA1223222A (en) 1984-02-22 1987-06-23 Nanibhushan Dattagupta Immobilized nucleic acid-containing probes
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4820630A (en) 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4883750A (en) 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3526565A1 (de) 1985-07-25 1987-02-05 Boehringer Mannheim Gmbh Resorufin-derivate, verfahren zu deren herstellung sowie deren verwendung in fluoreszenzimmunoassays
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4996143A (en) 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
GB8612087D0 (en) 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
JP2527340B2 (ja) 1986-12-15 1996-08-21 アプライド バイオシステムズ インコーポレイテッド ロ―ダミン染料の５−及び６−スクシニミジルカルボキシレ―ト異性体
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US4914210A (en) 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
ATE151467T1 (de) 1987-11-30 1997-04-15 Univ Iowa Res Found Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene
CA1323293C (en) 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
JP2856804B2 (ja) 1988-03-24 1999-02-10 ユニバーシティ オブ アイオワ リサーチ ファウンデイション 標識された相補的核酸プローブを開裂する触媒反応の補因子としての活性に基づく核酸配列検出のための触媒ハイブリッド形成系
EP0436547B1 (en) 1988-05-10 1994-11-30 E.I. Du Pont De Nemours And Company Process for rapid nucleic acid detection
AU629845B2 (en) 1988-08-30 1992-10-15 Abbott Laboratories Detection and amplification of target nucleic acid sequences
US5824796A (en) 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
US5849482A (en) 1988-09-28 1998-12-15 Epoch Pharmaceuticals, Inc. Crosslinking oligonucleotides
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5272259A (en) 1988-12-23 1993-12-21 Bayer Aktiengesellschaft Stilbene dyestuffs and light-polarizing films or sheets containing stilbene
EP0472648A4 (en) 1989-05-18 1992-09-16 Microprobe Corporation Crosslinking oligonucleotides
DE3916595A1 (de) 1989-05-22 1990-11-29 Boehringer Mannheim Gmbh Verfahren zur nichtradioaktiven messung der nucleinsaeuresynthese in eukaryontischen zellen
US5108892A (en) 1989-08-03 1992-04-28 Promega Corporation Method of using a taq dna polymerase without 5'-3'-exonuclease activity
US5451463A (en) 1989-08-28 1995-09-19 Clontech Laboratories, Inc. Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
ATE137269T1 (de) 1990-01-26 1996-05-15 Abbott Lab Verbessertes verfahren zur amplifikation von nuklein säurezielsequenz, einsetzbar für die polymerase und ligasekettenreaktion
US5214136A (en) 1990-02-20 1993-05-25 Gilead Sciences, Inc. Anthraquinone-derivatives oligonucleotides
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
DE69032425T2 (de) 1990-05-11 1998-11-26 Microprobe Corp., Bothell, Wash. Teststreifen zum Eintauchen für Nukleinsäure-Hybridisierungsassays und Verfahren zur kovalenten Immobilisierung von Oligonucleotiden
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5512667A (en) 1990-08-28 1996-04-30 Reed; Michael W. Trifunctional intermediates for preparing 3'-tailed oligonucleotides
EP0834576B1 (en) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
EP0528512A1 (en) 1991-08-20 1993-02-24 Pioneer Electronic Corporation Recording medium
WO1993009128A1 (en) 1991-11-07 1993-05-13 Nanotronics, Inc. Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
US5484908A (en) 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
TW393513B (en) 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
EP1044987B1 (en) 1991-12-24 2006-02-15 Isis Pharmaceuticals, Inc. Gapped 2'-modified oligonucleotides
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5801154A (en) 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
DE19509038A1 (de) 1995-03-14 1996-09-19 Boehringer Mannheim Gmbh C-Nukleosid-Derivate und deren Verwendung in der Detektion von Nukleinsäuren
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5801155A (en) 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
ATE196322T1 (de) 1995-05-05 2000-09-15 Perkin Elmer Corp Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
US6531589B1 (en) 1995-06-01 2003-03-11 Hybridon, Inc. Base protecting groups and synthons for oligonucleotide synthesis
WO1996040662A2 (en) 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
US6147205A (en) 1995-12-15 2000-11-14 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
GB9602265D0 (en) 1996-02-05 1996-04-03 Amersham Int Plc Benzophenoxazine dyes
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6576752B1 (en) 1997-02-14 2003-06-10 Isis Pharmaceuticals, Inc. Aminooxy functionalized oligomers
US6117973A (en) 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US5846726A (en) 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
JP2001514859A (ja) 1997-09-04 2001-09-18 バイエル コーポレイション クエンチ可能な蛍光標識を有するオリゴヌクレオチドプローブおよびその使用方法
DE69829760T3 (de) 1997-09-12 2016-04-14 Exiqon A/S Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
US6007992A (en) 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
DE69942444D1 (de) 1998-02-04 2010-07-15 Life Technologies Corp Bestimmung des genotyps eines amplifikationsproduktes an mehreren allelen stellen
DE19811618C1 (de) 1998-03-17 2000-08-31 Andreas Jenne Ribozym codierende DNA und ein Oligonucleotidsubstrat enthaltende Zusammensetzung und Verfahren zur Messung von Transkriptionsraten
US5952202A (en) 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
US6127121A (en) 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6117986A (en) 1998-06-10 2000-09-12 Intergen Company, L.P. Pyrimidines linked to a quencher
ATE277065T1 (de) 1999-01-05 2004-10-15 Bio Merieux Funktionalisierte verbindung, gegebenenfalls markierte polynukleotide und verfahren zur detektion einer ziel-nukleinsäure
US6255476B1 (en) 1999-02-22 2001-07-03 Pe Corporation (Ny) Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
JP2002541825A (ja) * 1999-04-08 2002-12-10 オアシス バイオサイエンシーズ インコーポレイティッド ユニバーサル及び／又は同義性塩基を含むアンチセンスオリゴヌクレオチド
AU751168B2 (en) 1999-04-23 2002-08-08 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
US6151241A (en) 1999-05-19 2000-11-21 Symetrix Corporation Ferroelectric memory with disturb protection
US6531591B1 (en) 1999-07-07 2003-03-11 Exiqon A/S Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
WO2001004129A1 (en) 1999-07-07 2001-01-18 Exiqon A/S Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
US6339147B1 (en) 1999-07-29 2002-01-15 Epoch Biosciences, Inc. Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
US6114518A (en) 1999-09-30 2000-09-05 Becton, Dickinson And Company Synthesis and use of labelled phosphoramidite compositions
US20040081959A9 (en) 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
WO2001070685A2 (en) 2000-03-22 2001-09-27 Solulink, Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US6465644B1 (en) 2000-05-02 2002-10-15 Applera Corporation Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6323337B1 (en) 2000-05-12 2001-11-27 Molecular Probes, Inc. Quenching oligonucleotides
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
DE60216468T2 (de) 2001-03-09 2007-09-27 Boston Probes, Inc., Bedford Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
US7122383B2 (en) 2001-03-16 2006-10-17 Qtl Biosystems, Llc Fluorescent polymer superquenching-based bioassays
US20030082547A1 (en) 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
CA2459347C (en) 2001-09-04 2012-10-09 Exiqon A/S Locked nucleic acid (lna) compositions and uses thereof
AU2003275018B2 (en) 2002-09-20 2009-10-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US20040180343A1 (en) 2003-03-12 2004-09-16 Weber Georg F. Compositions and methods for detecting nucleic acids
ATE408023T1 (de) 2003-06-17 2008-09-15 Medical Res Council Verfahren zum testen der lkb1- phosphorylierungsaktivität
US8012944B2 (en) * 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
US7439341B2 (en) 2003-11-14 2008-10-21 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
CA2494571C (en) 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
US20050288246A1 (en) * 2004-05-24 2005-12-29 Iversen Patrick L Peptide conjugated, inosine-substituted antisense oligomer compound and method
US20060178507A1 (en) 2004-12-30 2006-08-10 Berry & Associates, Inc. Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
JP5288681B2 (ja) 2005-04-05 2013-09-11 シキボウ株式会社 超微粒子シリカ分散液、超微粒子シリカ分散体及びこれらの製造方法
WO2006127507A2 (en) 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
WO2007106907A2 (en) 2006-03-15 2007-09-20 Integrated Dna Technologies, Inc. Nucleic acid monomers with 2'-chemical moieties
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
CN102037144B (zh) 2008-04-01 2013-09-25 生物检索技术股份有限公司 稳定化的核酸暗猝灭剂-荧光团探针
JP5291031B2 (ja) 2009-03-27 2013-09-18 株式会社エクシング カラオケシステム、カラオケシステムの制御方法、及びカラオケシステムの制御プログラム
EP2430187A2 (en) * 2009-05-12 2012-03-21 Abacus Diagnostica OY Method for detecting nucleic acids
WO2010147673A2 (en) 2009-06-19 2010-12-23 University Of Florida Research Foundation, Inc. Single-dna molecule nanomotor regulated by photons
US20110117559A1 (en) 2009-11-13 2011-05-19 Integrated Dna Technologies, Inc. Small rna detection assays
AU2011230496B2 (en) * 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
US8618253B2 (en) 2010-05-25 2013-12-31 Samsung Techwin Co., Ltd. Modified RNAse H and detection of nucleic acid amplification
CA2809457C (en) 2010-09-07 2019-07-30 Integrated Dna Technologies, Inc. Modifications for antisense compounds

Similar Documents

Publication Publication Date Title
JP2013539967A5 (enExample)
NZ584509A (en) Lipid-modified double-stranded rna having potent rna interference effect
JP2013040159A5 (ja) 有機金属錯体
JP2013063963A5 (ja) 複素環化合物
JP2014028916A5 (enExample)
JP2017093448A5 (enExample)
IN2015DN02238A (enExample)
JP2014054250A5 (enExample)
JP2013010096A5 (enExample)
HK1200171A1 (en) Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases
JP2014028784A5 (ja) 複素環化合物および有機化合物
JP2009094486A5 (enExample)
JP2012006912A5 (ja) トリアゾール誘導体
JP2007284431A5 (ja) 芳香族アミン化合物
JP2015042636A5 (ja) 有機化合物
EP2177556A3 (en) Silicone for preparing ophthalmic devices
JP2012121883A5 (ja) オキサジアゾール誘導体
MX369016B (es) Método de extracción de ácido desoxirribonucleico/ácido ribonucleico usando compuestos de amonio cuaternario sililados.
JP2009035530A5 (enExample)
JP2010079247A5 (enExample)
JP2013147490A5 (ja) イリジウム錯体
JP2010504286A5 (enExample)
JP2012054542A5 (ja) トリアゾール誘導体および複素環化合物
JP2013040118A5 (enExample)
AU2011230496A8 (en) Methods for enhancing nucleic acid hybridization