JP2013538218A5 - - Google Patents
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- Publication number
- JP2013538218A5 JP2013538218A5 JP2013528482A JP2013528482A JP2013538218A5 JP 2013538218 A5 JP2013538218 A5 JP 2013538218A5 JP 2013528482 A JP2013528482 A JP 2013528482A JP 2013528482 A JP2013528482 A JP 2013528482A JP 2013538218 A5 JP2013538218 A5 JP 2013538218A5
- Authority
- JP
- Japan
- Prior art keywords
- diene
- substituted
- dien
- aryl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 150000003505 terpenes Chemical class 0.000 claims 7
- 235000007586 terpenes Nutrition 0.000 claims 7
- ZHYZQXUYZJNEHD-UHFFFAOYSA-N trans-geranic acid Natural products CC(C)=CCCC(C)=CC(O)=O ZHYZQXUYZJNEHD-UHFFFAOYSA-N 0.000 claims 6
- 208000012902 Nervous system disease Diseases 0.000 claims 4
- 208000025966 Neurological disease Diseases 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- ZHYZQXUYZJNEHD-VQHVLOKHSA-N geranic acid Chemical compound CC(C)=CCC\C(C)=C\C(O)=O ZHYZQXUYZJNEHD-VQHVLOKHSA-N 0.000 claims 4
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- GRSIOXXNILKPOZ-CSKARUKUSA-N (1e)-2,6-dimethyl-1-methylsulfinylhepta-1,5-diene Chemical compound CC(C)=CCC\C(C)=C\S(C)=O GRSIOXXNILKPOZ-CSKARUKUSA-N 0.000 claims 2
- XYMVSHOREWBSIN-CSKARUKUSA-N (1e)-2,6-dimethyl-1-methylsulfonylhepta-1,5-diene Chemical compound CC(C)=CCC\C(C)=C\S(C)(=O)=O XYMVSHOREWBSIN-CSKARUKUSA-N 0.000 claims 2
- GSDGXBQWLNUBQA-WYMLVPIESA-N (1e)-2,6-dimethyl-n-phenylhepta-1,5-diene-1-sulfonamide Chemical compound CC(C)=CCC\C(C)=C\S(=O)(=O)NC1=CC=CC=C1 GSDGXBQWLNUBQA-WYMLVPIESA-N 0.000 claims 2
- IMAPKCUDRYUNRE-VQHVLOKHSA-N (1e)-2,6-dimethylhepta-1,5-diene-1-sulfonamide Chemical compound CC(C)=CCC\C(C)=C\S(N)(=O)=O IMAPKCUDRYUNRE-VQHVLOKHSA-N 0.000 claims 2
- LSSRHEDYTNQXIZ-CSKARUKUSA-N (1e)-n,2,6-trimethylhepta-1,5-diene-1-sulfonamide Chemical compound CNS(=O)(=O)\C=C(/C)CCC=C(C)C LSSRHEDYTNQXIZ-CSKARUKUSA-N 0.000 claims 2
- POQXRFKHXZIQFD-PKNBQFBNSA-N (1e)-n,n,2,6-tetramethylhepta-1,5-diene-1-sulfonamide Chemical compound CN(C)S(=O)(=O)\C=C(/C)CCC=C(C)C POQXRFKHXZIQFD-PKNBQFBNSA-N 0.000 claims 2
- OWSNAFRSUZEREE-FYWRMAATSA-N (1e)-n-benzyl-2,6-dimethylhepta-1,5-diene-1-sulfonamide Chemical compound CC(C)=CCC\C(C)=C\S(=O)(=O)NCC1=CC=CC=C1 OWSNAFRSUZEREE-FYWRMAATSA-N 0.000 claims 2
- GRSIOXXNILKPOZ-NTMALXAHSA-N (1z)-2,6-dimethyl-1-methylsulfinylhepta-1,5-diene Chemical compound CC(C)=CCC\C(C)=C/S(C)=O GRSIOXXNILKPOZ-NTMALXAHSA-N 0.000 claims 2
- LSSRHEDYTNQXIZ-NTMALXAHSA-N (1z)-n,2,6-trimethylhepta-1,5-diene-1-sulfonamide Chemical compound CNS(=O)(=O)\C=C(\C)CCC=C(C)C LSSRHEDYTNQXIZ-NTMALXAHSA-N 0.000 claims 2
- POQXRFKHXZIQFD-LUAWRHEFSA-N (1z)-n,n,2,6-tetramethylhepta-1,5-diene-1-sulfonamide Chemical compound CN(C)S(=O)(=O)\C=C(\C)CCC=C(C)C POQXRFKHXZIQFD-LUAWRHEFSA-N 0.000 claims 2
- AVJMJMPVWWWELJ-DHZHZOJOSA-N (2e)-1-methoxy-3,7-dimethylocta-2,6-diene Chemical compound COC\C=C(/C)CCC=C(C)C AVJMJMPVWWWELJ-DHZHZOJOSA-N 0.000 claims 2
- KOGQERXKVCKTES-DHZHZOJOSA-N (2e)-3,7-dimethyl-1-methylsulfinylocta-2,6-diene Chemical compound CC(C)=CCC\C(C)=C\CS(C)=O KOGQERXKVCKTES-DHZHZOJOSA-N 0.000 claims 2
- HRKYBDYVDGKSOW-DHZHZOJOSA-N (2e)-3,7-dimethyl-1-methylsulfonylocta-2,6-diene Chemical compound CC(C)=CCC\C(C)=C\CS(C)(=O)=O HRKYBDYVDGKSOW-DHZHZOJOSA-N 0.000 claims 2
- QDFMAKSWZWKJBD-WYMLVPIESA-N (2e)-3,7-dimethyl-1-phenylocta-2,6-dien-1-amine Chemical compound CC(C)=CCC\C(C)=C\C(N)C1=CC=CC=C1 QDFMAKSWZWKJBD-WYMLVPIESA-N 0.000 claims 2
- IZPMUPIMJWEMSO-WYMLVPIESA-N (2e)-3,7-dimethyl-n-phenylocta-2,6-dienamide Chemical compound CC(C)=CCC\C(C)=C\C(=O)NC1=CC=CC=C1 IZPMUPIMJWEMSO-WYMLVPIESA-N 0.000 claims 2
- AFMZGMJNKXOLEM-JXMROGBWSA-N (2e)-3,7-dimethylocta-2,6-dien-1-amine Chemical compound CC(C)=CCC\C(C)=C\CN AFMZGMJNKXOLEM-JXMROGBWSA-N 0.000 claims 2
- JJYIOZSRKCDLFJ-VQHVLOKHSA-N (2e)-3,7-dimethylocta-2,6-dienamide Chemical compound CC(C)=CCC\C(C)=C\C(N)=O JJYIOZSRKCDLFJ-VQHVLOKHSA-N 0.000 claims 2
- COPCIXHHBOFQSW-DHZHZOJOSA-N (2e)-n,3,7-trimethylocta-2,6-dien-1-amine Chemical compound CNC\C=C(/C)CCC=C(C)C COPCIXHHBOFQSW-DHZHZOJOSA-N 0.000 claims 2
- ZKQQGBOHAGHVLW-CSKARUKUSA-N (2e)-n,3,7-trimethylocta-2,6-dienamide Chemical compound CNC(=O)\C=C(/C)CCC=C(C)C ZKQQGBOHAGHVLW-CSKARUKUSA-N 0.000 claims 2
- ODZVUHGEGIBWOY-FMIVXFBMSA-N (2e)-n,n,3,7-tetramethylocta-2,6-dien-1-amine Chemical compound CN(C)C\C=C(/C)CCC=C(C)C ODZVUHGEGIBWOY-FMIVXFBMSA-N 0.000 claims 2
- UUKQMSUVUXFYFA-PKNBQFBNSA-N (2e)-n,n,3,7-tetramethylocta-2,6-dienamide Chemical compound CN(C)C(=O)\C=C(/C)CCC=C(C)C UUKQMSUVUXFYFA-PKNBQFBNSA-N 0.000 claims 2
- ZBDNKWRDCQVRLI-CSKARUKUSA-N (2e)-n-hydroxy-n,3,7-trimethylocta-2,6-dienamide Chemical compound CN(O)C(=O)\C=C(/C)CCC=C(C)C ZBDNKWRDCQVRLI-CSKARUKUSA-N 0.000 claims 2
- KLWKQJGISOJCFA-PKNBQFBNSA-N (2e)-n-methoxy-n,3,7-trimethylocta-2,6-dienamide Chemical compound CON(C)C(=O)\C=C(/C)CCC=C(C)C KLWKQJGISOJCFA-PKNBQFBNSA-N 0.000 claims 2
- ZHYZQXUYZJNEHD-CLFYSBASSA-N (2z)-3,7-dimethylocta-2,6-dienoic acid Chemical compound CC(C)=CCC\C(C)=C/C(O)=O ZHYZQXUYZJNEHD-CLFYSBASSA-N 0.000 claims 2
- DCPQHJVJESEDIF-VQHVLOKHSA-N (3e)-1,1,1-trifluoro-4,8-dimethyl-2-(trifluoromethyl)nona-3,7-dien-2-ol Chemical compound CC(C)=CCC\C(C)=C\C(O)(C(F)(F)F)C(F)(F)F DCPQHJVJESEDIF-VQHVLOKHSA-N 0.000 claims 2
- IAGHHLMECLYWED-VQHVLOKHSA-N (3e)-1,1,1-trifluoro-4,8-dimethylnona-3,7-dien-2-ol Chemical compound CC(C)=CCC\C(C)=C\C(O)C(F)(F)F IAGHHLMECLYWED-VQHVLOKHSA-N 0.000 claims 2
- NRPWZGOUEKWCHQ-VQHVLOKHSA-N (3e)-1,1,1-trifluoro-4,8-dimethylnona-3,7-dien-2-one Chemical compound CC(C)=CCC\C(C)=C\C(=O)C(F)(F)F NRPWZGOUEKWCHQ-VQHVLOKHSA-N 0.000 claims 2
- YXFLPSWTQNEFRJ-NTCAYCPXSA-N (3e)-4,8-dimethyl-1-phenylnona-3,7-dien-2-amine Chemical compound CC(C)=CCC\C(C)=C\C(N)CC1=CC=CC=C1 YXFLPSWTQNEFRJ-NTCAYCPXSA-N 0.000 claims 2
- APJDOKGRFWFIBN-CSKARUKUSA-N (3e)-4,8-dimethylnona-3,7-dien-2-amine Chemical compound CC(N)\C=C(/C)CCC=C(C)C APJDOKGRFWFIBN-CSKARUKUSA-N 0.000 claims 2
- LOFRGPAZTTVTDH-FMIVXFBMSA-N (4e)-2,5,9-trimethyldeca-4,8-dien-3-amine Chemical compound CC(C)C(N)\C=C(/C)CCC=C(C)C LOFRGPAZTTVTDH-FMIVXFBMSA-N 0.000 claims 2
- QRQGYNSDKLWMBN-FMIVXFBMSA-N (4e)-2,5,9-trimethyldeca-4,8-dien-3-ol Chemical compound CC(C)C(O)\C=C(/C)CCC=C(C)C QRQGYNSDKLWMBN-FMIVXFBMSA-N 0.000 claims 2
- WGYKAVWWNQSKEH-PKNBQFBNSA-N (4e)-5,9-dimethyldeca-4,8-dien-3-amine Chemical compound CCC(N)\C=C(/C)CCC=C(C)C WGYKAVWWNQSKEH-PKNBQFBNSA-N 0.000 claims 2
- IONXCPZMDZYBPG-ZRDIBKRKSA-N (5e)-4-amino-6,10-dimethylundeca-5,9-dien-1-ol Chemical compound CC(C)=CCC\C(C)=C\C(N)CCCO IONXCPZMDZYBPG-ZRDIBKRKSA-N 0.000 claims 2
- QHMQSWHACKGHTO-ZRDIBKRKSA-N (5e)-6,10-dimethylundeca-5,9-dien-4-amine Chemical compound CCCC(N)\C=C(/C)CCC=C(C)C QHMQSWHACKGHTO-ZRDIBKRKSA-N 0.000 claims 2
- QCWDCCWFZDXZEA-UHFFFAOYSA-N 5-(2,6-dimethylhepta-1,5-dienyl)-2h-tetrazole Chemical compound CC(C)=CCCC(C)=CC=1N=NNN=1 QCWDCCWFZDXZEA-UHFFFAOYSA-N 0.000 claims 2
- CZIKCULQMFMLMT-FOWTUZBSSA-N [(2e)-3,7-dimethylocta-2,6-dienoxy]methylbenzene Chemical compound CC(C)=CCC\C(C)=C\COCC1=CC=CC=C1 CZIKCULQMFMLMT-FOWTUZBSSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims 2
- 229930008392 geranic acid Natural products 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- ZKQQGBOHAGHVLW-UHFFFAOYSA-N n,3,7-trimethylocta-2,6-dienamide Chemical compound CNC(=O)C=C(C)CCC=C(C)C ZKQQGBOHAGHVLW-UHFFFAOYSA-N 0.000 claims 2
- SHLDGVXJLXKDJX-SDNWHVSQSA-N n-[(2e)-3,7-dimethylocta-2,6-dienyl]-2-hydroxybenzamide Chemical compound CC(C)=CCC\C(C)=C\CNC(=O)C1=CC=CC=C1O SHLDGVXJLXKDJX-SDNWHVSQSA-N 0.000 claims 2
- CJEIWYRAGBZMAB-DHZHZOJOSA-N n-[(2e)-3,7-dimethylocta-2,6-dienyl]acetamide Chemical compound CC(C)=CCC\C(C)=C\CNC(C)=O CJEIWYRAGBZMAB-DHZHZOJOSA-N 0.000 claims 2
- IRGQIMBPARYACF-NTCAYCPXSA-N n-[(2e)-3,7-dimethylocta-2,6-dienyl]benzamide Chemical compound CC(C)=CCC\C(C)=C\CNC(=O)C1=CC=CC=C1 IRGQIMBPARYACF-NTCAYCPXSA-N 0.000 claims 2
- WTEVQBCEXWBHNA-YFHOEESVSA-N neral Chemical compound CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38263510P | 2010-09-14 | 2010-09-14 | |
| US61/382,635 | 2010-09-14 | ||
| PCT/CA2011/050562 WO2012034232A1 (en) | 2010-09-14 | 2011-09-14 | Terpenoid analogues and uses thereof for treating neurological conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154978A Division JP2017008076A (ja) | 2010-09-14 | 2016-08-05 | 中枢神経系および末梢神経系における電気的障害を治療するためのテルペノイド類似体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013538218A JP2013538218A (ja) | 2013-10-10 |
| JP2013538218A5 true JP2013538218A5 (enExample) | 2014-10-30 |
Family
ID=45830903
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013528482A Pending JP2013538218A (ja) | 2010-09-14 | 2011-09-14 | 神経疾患を治療するためのテルペノイド類似体およびその使用 |
| JP2016154978A Pending JP2017008076A (ja) | 2010-09-14 | 2016-08-05 | 中枢神経系および末梢神経系における電気的障害を治療するためのテルペノイド類似体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154978A Pending JP2017008076A (ja) | 2010-09-14 | 2016-08-05 | 中枢神経系および末梢神経系における電気的障害を治療するためのテルペノイド類似体およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130267571A1 (enExample) |
| EP (1) | EP2616056A4 (enExample) |
| JP (2) | JP2013538218A (enExample) |
| CN (1) | CN103153297A (enExample) |
| CA (1) | CA2811241A1 (enExample) |
| WO (1) | WO2012034232A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101580857B1 (ko) | 2007-02-06 | 2015-12-30 | 네우로퀘스트 아이엔씨. | 신경 전달을 억제하기 위한 테르펜 화합물을 포함하는 조성물 및 방법 |
| EP2326323A4 (en) | 2008-08-13 | 2012-02-22 | Neuroquest Inc | COMPOSITION COMPRISING TERPENE COMPOUNDS FOR THE TREATMENT OF NEGATIVE SENSORY PHENOMENA |
| US20130085283A1 (en) * | 2011-10-04 | 2013-04-04 | Coyote Pharmaceuticals, Inc. | Geranylgeranylacetone derivatives |
| CN107935815A (zh) * | 2016-10-13 | 2018-04-20 | 浙江蓝天环保高科技股份有限公司 | 一种制备,1,1,3,3,3‑六氟‑2‑甲基‑2‑丙醇的方法 |
| CN109867659A (zh) * | 2017-12-04 | 2019-06-11 | 江苏恒瑞医药股份有限公司 | 苯并哌啶类衍生物的制备方法 |
| CN115583875B (zh) * | 2022-09-28 | 2023-12-01 | 联化科技（台州）有限公司 | 在连续流反应器中将烯丙型醇氧化为α,β-不饱和醛酮的方法 |
| CN119264026A (zh) * | 2024-10-03 | 2025-01-07 | 西北大学 | 机械光激发合成环状磺酰胺和磺酰烯烃的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260313A (en) * | 1992-03-12 | 1993-11-09 | National Pain Institute, Inc. | Diagnosis and treatment of various neuralgias |
| WO2007095631A2 (en) * | 2006-02-15 | 2007-08-23 | The Regents Of The University Of California | New drug delivery system for crossing the blood brain barrier |
| WO2008108825A2 (en) * | 2006-10-10 | 2008-09-12 | Burnham Institute For Medical Research | Neuroprotective compositions and methods |
| KR101580857B1 (ko) * | 2007-02-06 | 2015-12-30 | 네우로퀘스트 아이엔씨. | 신경 전달을 억제하기 위한 테르펜 화합물을 포함하는 조성물 및 방법 |
| EP2326323A4 (en) * | 2008-08-13 | 2012-02-22 | Neuroquest Inc | COMPOSITION COMPRISING TERPENE COMPOUNDS FOR THE TREATMENT OF NEGATIVE SENSORY PHENOMENA |
| US20120128787A1 (en) * | 2008-11-18 | 2012-05-24 | Origin Biomed Inc. | Homeopathic Composition Comprising Hypericum Perforatum Extract And Essential Oils For The Treatment Of Neuropathic Pain |
-
2011
- 2011-09-14 EP EP11824405.2A patent/EP2616056A4/en not_active Withdrawn
- 2011-09-14 US US13/822,826 patent/US20130267571A1/en not_active Abandoned
- 2011-09-14 JP JP2013528482A patent/JP2013538218A/ja active Pending
- 2011-09-14 CN CN2011800498172A patent/CN103153297A/zh active Pending
- 2011-09-14 CA CA2811241A patent/CA2811241A1/en not_active Abandoned
- 2011-09-14 WO PCT/CA2011/050562 patent/WO2012034232A1/en not_active Ceased
-
2016
- 2016-08-05 JP JP2016154978A patent/JP2017008076A/ja active Pending