JP2013536807A5 - - Google Patents

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Publication number
JP2013536807A5
JP2013536807A5 JP2013526337A JP2013526337A JP2013536807A5 JP 2013536807 A5 JP2013536807 A5 JP 2013536807A5 JP 2013526337 A JP2013526337 A JP 2013526337A JP 2013526337 A JP2013526337 A JP 2013526337A JP 2013536807 A5 JP2013536807 A5 JP 2013536807A5
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JP
Japan
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cancer
alkyl
tumor
compound according
disease
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JP2013526337A
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English (en)
Japanese (ja)
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JP2013536807A (ja
JP6039559B2 (ja
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Priority claimed from PCT/EP2011/003949 external-priority patent/WO2012028243A1/en
Publication of JP2013536807A publication Critical patent/JP2013536807A/ja
Publication of JP2013536807A5 publication Critical patent/JP2013536807A5/ja
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Publication of JP6039559B2 publication Critical patent/JP6039559B2/ja
Expired - Fee Related legal-status Critical Current
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JP2013526337A 2010-09-02 2011-08-05 Lpa受容体アンタゴニストとしてのピラゾロピリジノン誘導体 Expired - Fee Related JP6039559B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10009117 2010-09-02
EP10009117.2 2010-09-02
PCT/EP2011/003949 WO2012028243A1 (en) 2010-09-02 2011-08-05 Pyrazolopyridinone derivatives as lpa receptor antagonists

Publications (3)

Publication Number Publication Date
JP2013536807A JP2013536807A (ja) 2013-09-26
JP2013536807A5 true JP2013536807A5 (https=) 2014-09-18
JP6039559B2 JP6039559B2 (ja) 2016-12-07

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ID=44532738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013526337A Expired - Fee Related JP6039559B2 (ja) 2010-09-02 2011-08-05 Lpa受容体アンタゴニストとしてのピラゾロピリジノン誘導体

Country Status (10)

Country Link
US (2) US8859775B2 (https=)
EP (1) EP2611808B1 (https=)
JP (1) JP6039559B2 (https=)
CN (1) CN103189378B (https=)
AR (1) AR082880A1 (https=)
AU (1) AU2011297961B2 (https=)
CA (1) CA2809892C (https=)
ES (1) ES2530345T3 (https=)
IL (1) IL225015A (https=)
WO (1) WO2012028243A1 (https=)

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CA2992889A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
CA2998753A1 (en) 2015-09-18 2017-03-23 St. Jude Children's Research Hospital Methods and compositions of inhibiting dcn1-ubc12 interaction
JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Atx阻害剤としての二環式化合物
WO2017050732A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
AU2016328436B2 (en) 2015-09-24 2020-05-14 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
BR112017026682A2 (pt) 2015-09-24 2018-08-14 Hoffmann La Roche novos compostos bicíclicos como inibidores de dupla ação de atx/ca
AU2017250779B2 (en) * 2016-04-14 2022-03-10 Mars, Incorporated Methods for identifying modulators of GPR92
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ.ホフマン-ラ ロシュ アーゲー Atxインヒビターとしての新規二環式化合物
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JP7050165B2 (ja) 2018-02-26 2022-04-07 ギリアード サイエンシーズ, インコーポレイテッド Hbv複製阻害剤としての置換ピロリジン化合物
CN111902144A (zh) 2018-03-30 2020-11-06 第一三共株式会社 Lcat缺乏的治疗剂
CN108558876B (zh) * 2018-05-28 2020-08-04 中南大学 吡唑[3,4-b]并吡啶类衍生物及其制备方法和应用
CN108379275B (zh) * 2018-05-29 2020-05-22 中国医学科学院阜外医院 溶血磷脂酸、溶血磷脂酸受体3以及溶血磷脂酸受体3激动剂的应用
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KR20220044479A (ko) * 2019-06-20 2022-04-08 유니버시티 오브 켄터키 리서치 파운데이션 Dcn1/2-매개된 큐린 네딜화의 약학적 활성 피라졸로-피리돈 조절제
US20230043672A1 (en) 2019-12-12 2023-02-09 Chiesi Farmaceutici S.P.A. Aromatic amido derivatives as lpa receptor 2 inhibitors
WO2021116257A1 (en) 2019-12-12 2021-06-17 Chiesi Farmaceutici S.P.A. Thienopyrimidine derivatives as lpa receptor 2 inhibitors
CN114786771A (zh) 2019-12-12 2022-07-22 奇斯药制品公司 作为lpa受体2抑制剂的喹唑啉衍生物
CA3185111A1 (en) 2020-07-16 2022-01-20 Elisabetta Armani Amido cyclohexane acid derivatives as lpa receptor inhibitors
WO2022174882A1 (en) 2021-02-16 2022-08-25 Chiesi Farmaceutici S.P.A. 5-membered heterocyclyl carbamate derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors
WO2022174883A1 (en) 2021-02-16 2022-08-25 Chiesi Farmaceutici S.P.A. 5-membered heterocyclyl derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors
CN117043144A (zh) 2021-03-24 2023-11-10 奇斯药制品公司 作为lpa受体2抑制剂的8-环-取代的喹唑啉衍生物
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