JP2024522373A5 - - Google Patents
Info
- Publication number
- JP2024522373A5 JP2024522373A5 JP2023576009A JP2023576009A JP2024522373A5 JP 2024522373 A5 JP2024522373 A5 JP 2024522373A5 JP 2023576009 A JP2023576009 A JP 2023576009A JP 2023576009 A JP2023576009 A JP 2023576009A JP 2024522373 A5 JP2024522373 A5 JP 2024522373A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutically acceptable
- independently selected
- acceptable salt
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163209555P | 2021-06-11 | 2021-06-11 | |
| US63/209,555 | 2021-06-11 | ||
| US202263319826P | 2022-03-15 | 2022-03-15 | |
| US63/319,826 | 2022-03-15 | ||
| PCT/IB2022/055384 WO2022259204A1 (en) | 2021-06-11 | 2022-06-09 | O-linked thiadiazolyl compounds as dna polymerase theta inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024522373A JP2024522373A (ja) | 2024-06-18 |
| JP2024522373A5 true JP2024522373A5 (https=) | 2025-06-13 |
Family
ID=82358548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023576009A Pending JP2024522373A (ja) | 2021-06-11 | 2022-06-09 | Ｄｎａポリメラーゼシータ阻害剤としてのｏ結合チアジアゾリル化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20240287080A1 (https=) |
| EP (1) | EP4352055A1 (https=) |
| JP (1) | JP2024522373A (https=) |
| KR (1) | KR20240044412A (https=) |
| AU (1) | AU2022289762B2 (https=) |
| BR (1) | BR112023025245A2 (https=) |
| CA (1) | CA3222078A1 (https=) |
| CL (1) | CL2023003671A1 (https=) |
| CO (1) | CO2023017082A2 (https=) |
| IL (1) | IL308912A (https=) |
| MX (1) | MX2023014665A (https=) |
| TW (1) | TW202315618A (https=) |
| WO (1) | WO2022259204A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023202623A1 (zh) * | 2022-04-20 | 2023-10-26 | 南京再明医药有限公司 | Polq抑制剂化合物及其应用 |
| AU2023352129A1 (en) * | 2022-09-29 | 2025-05-01 | Repare Therapeutics Inc. | N-(5-substituted-[(1,3,4-thiadiazolyl) or (1,3-thiazolyl)](substituted)carboxamide compounds, pharmaceutical compositions, and methods of preparing the amide compounds and of their use |
| CN117946138A (zh) * | 2022-10-28 | 2024-04-30 | 杭州圣域生物医药科技有限公司 | 并环含氮化合物、其中间体、制备方法和应用 |
| WO2024099336A1 (en) * | 2022-11-10 | 2024-05-16 | Danatlas Pharmaceuticals Co., Ltd. | Thiadiazolyl derivatives, compositions and uses thereof |
| JP2025541823A (ja) * | 2022-12-09 | 2025-12-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー４）、リミテッド | Ｄｎａポリメラーゼシータ阻害剤としてのチアジアゾリル誘導体およびその使用 |
| WO2024149349A1 (zh) * | 2023-01-14 | 2024-07-18 | 西藏海思科制药有限公司 | 靶向Polθ的化合物及其用途 |
| TW202502745A (zh) * | 2023-02-28 | 2025-01-16 | 美商賽堤爾醫療公司 | ４，５－稠和雙環吡咯啶及４，５－稠和雙環吡咯啶－酮化合物 |
| US12215102B2 (en) * | 2023-02-28 | 2025-02-04 | Reglagene, Inc. | Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions |
| KR20250153866A (ko) | 2023-03-10 | 2025-10-27 | 브레이크포인트 테라퓨틱스 게엠베하 | Dna 중합효소 세타 억제제 |
| WO2024211836A2 (en) | 2023-04-05 | 2024-10-10 | Moma Therapeutics, Inc. | Semi-saturated bicyclic derivatives and related uses |
| WO2024213082A1 (en) * | 2023-04-13 | 2024-10-17 | Danatlas Pharmaceuticals Co., Ltd. | Thiadiazolone derivatives, compositions and uses thereof |
| CN121712768A (zh) * | 2023-05-30 | 2026-03-20 | 宁波新湾科技发展有限公司 | 噻唑基或噻二唑基酰胺衍生物及其用途 |
| CN121399118A (zh) * | 2023-06-02 | 2026-01-23 | 成都微芯药业有限公司 | Polθ抑制剂及其制备方法和用途 |
| EP4727540A2 (en) * | 2023-06-16 | 2026-04-22 | Quantx Biosciences US, Inc. | Fused bicyclic heterocyclic or hetero aryl amide compounds |
| WO2025011617A1 (zh) * | 2023-07-12 | 2025-01-16 | 杭州圣域生物医药科技有限公司 | 并环杂芳环类化合物、其中间体、制备方法和应用 |
| WO2025016391A1 (zh) * | 2023-07-18 | 2025-01-23 | 南京再明医药有限公司 | 噻唑并吡嗪类化合物及其应用 |
| CN121773109A (zh) * | 2023-07-27 | 2026-03-31 | 北京丹擎医药科技有限公司 | PolQ降解剂及其组合物和应用 |
| WO2025036490A1 (zh) * | 2023-08-17 | 2025-02-20 | 海思科医药集团股份有限公司 | 一种DNA聚合酶θ抑制剂及其用途 |
| KR20260040065A (ko) * | 2023-09-01 | 2026-03-23 | 항저우 신알엑스 테라퓨틱스 바이오메디컬 테크놀로지 컴퍼니 리미티드 | 바이아릴 고리계 화합물, 이의 중간체, 제조 방법 및 용도 |
| CN117229260B (zh) * | 2023-11-13 | 2024-02-27 | 中国药科大学 | DNA聚合酶θ与聚ADP核糖聚合酶1双靶点抑制剂及其制备方法和医药用途 |
| WO2025110780A1 (en) * | 2023-11-24 | 2025-05-30 | Daewoong Pharmaceutical Co., Ltd. | Novel heterocyclic compounds and pharmaceutical composition comprising the same as dna polymerase theta inhibitors for the prevention or treatment of cancer |
| WO2025165092A1 (en) * | 2024-01-30 | 2025-08-07 | Daewoong Pharmaceutical Co., Ltd. | Novel heterocyclic compounds and pharmaceutical composition comprising the same as dna polymerase theta inhibitors for the prevention or treatment of cancer |
| CN120829441A (zh) * | 2024-04-24 | 2025-10-24 | 杭州圣域生物医药科技有限公司 | 一种并环含氮化合物及其中间体的制备方法 |
| CN120829442A (zh) * | 2024-04-24 | 2025-10-24 | 杭州圣域生物医药科技有限公司 | 一种并环含氮化合物及其中间体的制备方法 |
| WO2025223483A1 (zh) * | 2024-04-24 | 2025-10-30 | 杭州圣域生物医药科技有限公司 | 并环含氮化合物、其晶型及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
| EP3034500A1 (en) * | 2014-12-17 | 2016-06-22 | Genkyotex Sa | Amido thiazole derivatives as NADPH oxidase inhibitors |
| USRE50319E1 (en) * | 2017-10-16 | 2025-03-04 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| AU2020282768B2 (en) * | 2019-05-31 | 2023-09-14 | Ideaya Biosciences, Inc. | Thiadiazolyl derivatives as DNA Polymerase Theta inhibitors |
| TW202237595A (zh) * | 2020-12-02 | 2022-10-01 | 美商愛德亞生物科學公司 | 作為DNA聚合酶θ抑制劑之經取代噻二唑基衍生物 |
-
2022
- 2022-06-08 TW TW111121145A patent/TW202315618A/zh unknown
- 2022-06-09 EP EP22735990.8A patent/EP4352055A1/en active Pending
- 2022-06-09 JP JP2023576009A patent/JP2024522373A/ja active Pending
- 2022-06-09 AU AU2022289762A patent/AU2022289762B2/en active Active
- 2022-06-09 KR KR1020247000980A patent/KR20240044412A/ko active Pending
- 2022-06-09 CA CA3222078A patent/CA3222078A1/en active Pending
- 2022-06-09 MX MX2023014665A patent/MX2023014665A/es unknown
- 2022-06-09 WO PCT/IB2022/055384 patent/WO2022259204A1/en not_active Ceased
- 2022-06-09 IL IL308912A patent/IL308912A/en unknown
- 2022-06-09 US US18/567,687 patent/US20240287080A1/en active Pending
- 2022-06-09 BR BR112023025245A patent/BR112023025245A2/pt unknown
-
2023
- 2023-12-07 CO CONC2023/0017082A patent/CO2023017082A2/es unknown
- 2023-12-07 CL CL2023003671A patent/CL2023003671A1/es unknown
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