JP2023552764A5 - - Google Patents
Info
- Publication number
- JP2023552764A5 JP2023552764A5 JP2023533774A JP2023533774A JP2023552764A5 JP 2023552764 A5 JP2023552764 A5 JP 2023552764A5 JP 2023533774 A JP2023533774 A JP 2023533774A JP 2023533774 A JP2023533774 A JP 2023533774A JP 2023552764 A5 JP2023552764 A5 JP 2023552764A5
- Authority
- JP
- Japan
- Prior art keywords
- independently selected
- ring
- alkyl
- pharmaceutically acceptable
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063120410P | 2020-12-02 | 2020-12-02 | |
| US63/120,410 | 2020-12-02 | ||
| US202163232749P | 2021-08-13 | 2021-08-13 | |
| US63/232,749 | 2021-08-13 | ||
| PCT/IB2021/061173 WO2022118210A1 (en) | 2020-12-02 | 2021-12-01 | Substituted thiadiazolyl derivatives as dna polymerase theta inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023552764A JP2023552764A (ja) | 2023-12-19 |
| JP2023552764A5 true JP2023552764A5 (https=) | 2024-11-20 |
Family
ID=78824758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023533774A Pending JP2023552764A (ja) | 2020-12-02 | 2021-12-01 | Ｄｎａポリメラーゼシータ阻害剤としての置換チアジアゾリル誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250325552A1 (https=) |
| EP (1) | EP4255573A1 (https=) |
| JP (1) | JP2023552764A (https=) |
| AU (1) | AU2021390194B2 (https=) |
| CA (1) | CA3200006A1 (https=) |
| TW (1) | TW202237595A (https=) |
| WO (1) | WO2022118210A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202315618A (zh) * | 2021-06-11 | 2023-04-16 | 美商愛德亞生物科學公司 | 作為DNA聚合酶θ抑制劑之O-聯結噻二唑基化合物 |
| WO2023202623A1 (zh) * | 2022-04-20 | 2023-10-26 | 南京再明医药有限公司 | Polq抑制剂化合物及其应用 |
| CA3257870A1 (en) * | 2022-06-01 | 2023-12-07 | Ideaya Biosciences, Inc. | THIADIAZOLYL DERIVATIVES USED AS DNA POLYMERASE THETA INHIBITORS AND THEIR USES |
| AU2023352129A1 (en) * | 2022-09-29 | 2025-05-01 | Repare Therapeutics Inc. | N-(5-substituted-[(1,3,4-thiadiazolyl) or (1,3-thiazolyl)](substituted)carboxamide compounds, pharmaceutical compositions, and methods of preparing the amide compounds and of their use |
| CN117946138A (zh) * | 2022-10-28 | 2024-04-30 | 杭州圣域生物医药科技有限公司 | 并环含氮化合物、其中间体、制备方法和应用 |
| WO2024099336A1 (en) * | 2022-11-10 | 2024-05-16 | Danatlas Pharmaceuticals Co., Ltd. | Thiadiazolyl derivatives, compositions and uses thereof |
| CN120077028A (zh) * | 2022-11-10 | 2025-05-30 | 北京丹擎医药科技有限公司 | 噻二唑衍生物及其组合物和应用 |
| JP2025541823A (ja) * | 2022-12-09 | 2025-12-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー４）、リミテッド | Ｄｎａポリメラーゼシータ阻害剤としてのチアジアゾリル誘導体およびその使用 |
| WO2024149349A1 (zh) * | 2023-01-14 | 2024-07-18 | 西藏海思科制药有限公司 | 靶向Polθ的化合物及其用途 |
| KR20250153866A (ko) | 2023-03-10 | 2025-10-27 | 브레이크포인트 테라퓨틱스 게엠베하 | Dna 중합효소 세타 억제제 |
| WO2024211836A2 (en) * | 2023-04-05 | 2024-10-10 | Moma Therapeutics, Inc. | Semi-saturated bicyclic derivatives and related uses |
| AU2024254066A1 (en) * | 2023-04-05 | 2025-10-16 | Moma Therapeutics, Inc. | Biaryl derivatives and related uses |
| WO2024213082A1 (en) * | 2023-04-13 | 2024-10-17 | Danatlas Pharmaceuticals Co., Ltd. | Thiadiazolone derivatives, compositions and uses thereof |
| CN121712768A (zh) * | 2023-05-30 | 2026-03-20 | 宁波新湾科技发展有限公司 | 噻唑基或噻二唑基酰胺衍生物及其用途 |
| CN121399118A (zh) * | 2023-06-02 | 2026-01-23 | 成都微芯药业有限公司 | Polθ抑制剂及其制备方法和用途 |
| WO2025011617A1 (zh) * | 2023-07-12 | 2025-01-16 | 杭州圣域生物医药科技有限公司 | 并环杂芳环类化合物、其中间体、制备方法和应用 |
| WO2025016391A1 (zh) * | 2023-07-18 | 2025-01-23 | 南京再明医药有限公司 | 噻唑并吡嗪类化合物及其应用 |
| CN121773109A (zh) * | 2023-07-27 | 2026-03-31 | 北京丹擎医药科技有限公司 | PolQ降解剂及其组合物和应用 |
| WO2025036490A1 (zh) * | 2023-08-17 | 2025-02-20 | 海思科医药集团股份有限公司 | 一种DNA聚合酶θ抑制剂及其用途 |
| WO2025165092A1 (en) * | 2024-01-30 | 2025-08-07 | Daewoong Pharmaceutical Co., Ltd. | Novel heterocyclic compounds and pharmaceutical composition comprising the same as dna polymerase theta inhibitors for the prevention or treatment of cancer |
| CN120829441A (zh) * | 2024-04-24 | 2025-10-24 | 杭州圣域生物医药科技有限公司 | 一种并环含氮化合物及其中间体的制备方法 |
| CN120829442A (zh) * | 2024-04-24 | 2025-10-24 | 杭州圣域生物医药科技有限公司 | 一种并环含氮化合物及其中间体的制备方法 |
| WO2025223483A1 (zh) * | 2024-04-24 | 2025-10-30 | 杭州圣域生物医药科技有限公司 | 并环含氮化合物、其晶型及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| EP3034500A1 (en) * | 2014-12-17 | 2016-06-22 | Genkyotex Sa | Amido thiazole derivatives as NADPH oxidase inhibitors |
| WO2019028104A1 (en) * | 2017-08-02 | 2019-02-07 | Alphala Co., Ltd. | NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
| BR112021014977A2 (pt) * | 2019-01-30 | 2021-10-05 | Ideaya Biosciences, Inc. | Derivados de acetamido como inibidores de dna polimerase teta |
| JP2022519535A (ja) * | 2019-01-31 | 2022-03-24 | イデアヤ、バイオサイエンシズ、インコーポレイテッド | Ｄｎａポリメラーゼシータ阻害剤としてのヘテロアリールメチレン誘導体 |
| AU2020282768B2 (en) * | 2019-05-31 | 2023-09-14 | Ideaya Biosciences, Inc. | Thiadiazolyl derivatives as DNA Polymerase Theta inhibitors |
-
2021
- 2021-11-29 TW TW110144406A patent/TW202237595A/zh unknown
- 2021-12-01 EP EP21820704.1A patent/EP4255573A1/en active Pending
- 2021-12-01 US US18/255,306 patent/US20250325552A1/en active Pending
- 2021-12-01 WO PCT/IB2021/061173 patent/WO2022118210A1/en not_active Ceased
- 2021-12-01 JP JP2023533774A patent/JP2023552764A/ja active Pending
- 2021-12-01 CA CA3200006A patent/CA3200006A1/en active Pending
- 2021-12-01 AU AU2021390194A patent/AU2021390194B2/en active Active
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