JP2013536696A5 - - Google Patents
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- Publication number
- JP2013536696A5 JP2013536696A5 JP2013527735A JP2013527735A JP2013536696A5 JP 2013536696 A5 JP2013536696 A5 JP 2013536696A5 JP 2013527735 A JP2013527735 A JP 2013527735A JP 2013527735 A JP2013527735 A JP 2013527735A JP 2013536696 A5 JP2013536696 A5 JP 2013536696A5
- Authority
- JP
- Japan
- Prior art keywords
- pluripotent stem
- stem cells
- culture
- cells
- aggregates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 35
- 238000000034 method Methods 0.000 claims 22
- 210000001671 embryonic stem cell Anatomy 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 239000001963 growth medium Substances 0.000 claims 10
- 238000004114 suspension culture Methods 0.000 claims 10
- 238000012258 culturing Methods 0.000 claims 7
- 102000003815 Interleukin-11 Human genes 0.000 claims 5
- 108090000177 Interleukin-11 Proteins 0.000 claims 5
- 238000010494 dissociation reaction Methods 0.000 claims 5
- 230000005593 dissociations Effects 0.000 claims 5
- 210000002242 embryoid body Anatomy 0.000 claims 5
- 229940074383 interleukin-11 Drugs 0.000 claims 5
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 claims 2
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 claims 2
- 210000002459 blastocyst Anatomy 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 210000003981 ectoderm Anatomy 0.000 claims 2
- 210000001654 germ layer Anatomy 0.000 claims 2
- 210000003716 mesoderm Anatomy 0.000 claims 2
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 2
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000000356 contaminant Substances 0.000 claims 1
- 210000001900 endoderm Anatomy 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38038810P | 2010-09-07 | 2010-09-07 | |
| US61/380,388 | 2010-09-07 | ||
| PCT/IL2011/000722 WO2012032521A2 (en) | 2010-09-07 | 2011-09-07 | Novel methods and culture media for culturing pluripotent stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017113227A Division JP6574458B2 (ja) | 2010-09-07 | 2017-06-08 | 多能性幹細胞を培養するための新規な方法および培養培地 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536696A JP2013536696A (ja) | 2013-09-26 |
| JP2013536696A5 true JP2013536696A5 (OSRAM) | 2014-10-23 |
| JP6283223B2 JP6283223B2 (ja) | 2018-02-21 |
Family
ID=44936324
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527735A Active JP6283223B2 (ja) | 2010-09-07 | 2011-09-07 | 多能性幹細胞を培養するための新規な方法および培養培地 |
| JP2017113227A Active JP6574458B2 (ja) | 2010-09-07 | 2017-06-08 | 多能性幹細胞を培養するための新規な方法および培養培地 |
| JP2019149488A Pending JP2020000241A (ja) | 2010-09-07 | 2019-08-16 | 多能性幹細胞を培養するための新規な方法および培養培地 |
| JP2022007129A Active JP7357086B2 (ja) | 2010-09-07 | 2022-01-20 | 多能性幹細胞を培養するための新規な方法および培養培地 |
| JP2023161645A Active JP7663644B2 (ja) | 2010-09-07 | 2023-09-25 | 多能性幹細胞を培養するための新規な方法および培養培地 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017113227A Active JP6574458B2 (ja) | 2010-09-07 | 2017-06-08 | 多能性幹細胞を培養するための新規な方法および培養培地 |
| JP2019149488A Pending JP2020000241A (ja) | 2010-09-07 | 2019-08-16 | 多能性幹細胞を培養するための新規な方法および培養培地 |
| JP2022007129A Active JP7357086B2 (ja) | 2010-09-07 | 2022-01-20 | 多能性幹細胞を培養するための新規な方法および培養培地 |
| JP2023161645A Active JP7663644B2 (ja) | 2010-09-07 | 2023-09-25 | 多能性幹細胞を培養するための新規な方法および培養培地 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US10214722B2 (OSRAM) |
| EP (2) | EP3572501B1 (OSRAM) |
| JP (5) | JP6283223B2 (OSRAM) |
| CA (2) | CA2810488C (OSRAM) |
| DK (1) | DK2614141T3 (OSRAM) |
| ES (1) | ES2746482T3 (OSRAM) |
| IL (4) | IL225070B (OSRAM) |
| SG (4) | SG188411A1 (OSRAM) |
| WO (1) | WO2012032521A2 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102660495A (zh) | 2006-04-14 | 2012-09-12 | 先进细胞技术公司 | 血管瘤集落形成细胞 |
| WO2011058558A2 (en) | 2009-11-12 | 2011-05-19 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| EP3572501B1 (en) | 2010-09-07 | 2025-07-16 | Technion Research & Development Foundation Limited | Novel methods and culture media for culturing pluripotent stem cells |
| JP5745919B2 (ja) * | 2011-04-28 | 2015-07-08 | 浜松ホトニクス株式会社 | 細胞解析方法、細胞解析装置、および細胞解析プログラム |
| US9175263B2 (en) * | 2012-08-22 | 2015-11-03 | Biotime, Inc. | Methods and compositions for targeting progenitor cell lines |
| EP3888640B1 (en) | 2013-06-05 | 2025-09-17 | Reverse Bioengineering, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
| US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
| WO2015181253A1 (en) * | 2014-05-27 | 2015-12-03 | Fundación Pública Andaluza Progreso Y Salud | Neural progenitor cell population |
| US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
| US9944894B2 (en) | 2015-01-16 | 2018-04-17 | General Electric Company | Pluripotent stem cell expansion and passage using a rocking platform bioreactor |
| EP3279318A4 (en) * | 2015-03-30 | 2018-08-29 | Ajinomoto Co., Inc. | Human serum albumin-containing culture medium for growth of neural stem cells |
| WO2016183593A2 (en) * | 2015-05-14 | 2016-11-17 | The Regents Of The University Of California | Prenatal therapy |
| CN105002134B (zh) * | 2015-07-24 | 2018-08-17 | 北京大学 | 制备多潜能干细胞的组合物、方法、试剂盒及其用途 |
| US11286454B2 (en) * | 2015-08-31 | 2022-03-29 | I Peace, Inc. | Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells |
| CA3202332A1 (en) | 2015-12-07 | 2017-06-15 | Agex Therapeutics, Inc. | Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells |
| US12402609B2 (en) * | 2016-01-13 | 2025-09-02 | Felix Pets, Llc | Methods for producing hypo-allergenic cats using gene editing technology |
| KR101855967B1 (ko) | 2016-03-11 | 2018-05-10 | 가톨릭관동대학교산학협력단 | 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법 |
| JP7002530B2 (ja) * | 2016-03-29 | 2022-02-04 | エスエムエスバイオテック インコーポレイテッド | 小型運動性幹細胞を使用した組成物および方法 |
| EP3487987A4 (en) * | 2016-07-19 | 2020-02-19 | Accellta Ltd. | CULTURAL MEDIA FOR THE CULTURE OF PLURIPOTENTAL STEM CELLS IN A SUSPENSION |
| WO2018194161A1 (ja) * | 2017-04-20 | 2018-10-25 | 国立大学法人東北大学 | 振盪浮遊培養を用いた間葉系幹細胞の未分化性維持方法 |
| JPWO2019181999A1 (ja) * | 2018-03-20 | 2021-02-04 | 富士フイルム株式会社 | 多能性幹細胞を三次元培養する方法 |
| KR102175792B1 (ko) * | 2018-11-20 | 2020-11-06 | 사회복지법인 삼성생명공익재단 | 줄기세포의 증식능을 탐지하기 위한 마커 및 이를 이용한 줄기세포의 고효율 증식방법 |
| WO2020206187A1 (en) * | 2019-04-02 | 2020-10-08 | Centagen, Inc | Engineered system of stem cell rejuvenation to treat aging and disease |
| WO2020206409A1 (en) | 2019-04-04 | 2020-10-08 | Synaptec Network, Inc. | Systems and methods for using low intensity ultrasonic transducer on the brain |
| CN114401740A (zh) * | 2019-05-30 | 2022-04-26 | 伊美诺路克斯国际公司 | 痘病毒与自体诱导性多能干细胞用于疫苗接种和疾病治疗的用途 |
| US20230014770A1 (en) * | 2019-12-09 | 2023-01-19 | Daewoong Pharmaceutical Co., Ltd. | Method for preparation of mesenchymal stem cell from human pluripotent stem cell and mesenchymal stem cells prepared thereby |
| CN114981411A (zh) * | 2020-01-14 | 2022-08-30 | 味之素株式会社 | 细胞的培养方法 |
| JP7753883B2 (ja) * | 2020-01-14 | 2025-10-15 | 味の素株式会社 | 細胞培養用培地組成物 |
| CN115135755A (zh) * | 2020-02-12 | 2022-09-30 | 株式会社钟化 | 多能干细胞分化的抑制方法 |
| CN116096860A (zh) * | 2020-07-02 | 2023-05-09 | 阿塞尔塔有限公司 | 来自延迟胚胎的哺乳动物牲畜多能干细胞系 |
| EP4189069A4 (en) * | 2020-08-03 | 2024-08-28 | So Young Life Sciences Corporation | COMBINATION TREATMENT OF INDUCED PLURIPOTENT STEM CELLS WITH INTERLEUKINS |
| IL309185A (en) * | 2021-06-09 | 2024-02-01 | Accellta Ltd | Serum-free media for suspension cultivation of pluripotent stem cells from mammalian farm animals |
| CN114350599B (zh) * | 2022-01-14 | 2024-01-19 | 内蒙古大学 | 一种增强牛胚胎干细胞的多能性和代谢活力的培养体系和培养方法 |
| CN119278260A (zh) * | 2022-05-24 | 2025-01-07 | 蓝岩治疗有限公司 | 制备少突胶质细胞祖细胞的方法 |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| WO2024247915A1 (ja) * | 2023-05-26 | 2024-12-05 | 学校法人関西医科大学 | 骨髄ニッチ細胞およびその製造方法 |
| WO2025006477A2 (en) * | 2023-06-27 | 2025-01-02 | The Board Of Regents Of The University Of Texas System | System and methods for generation of human fetal progenitors, tissues, and organs from cultured stem cells |
| WO2025106665A1 (en) * | 2023-11-15 | 2025-05-22 | Immorta Bio, Inc. | Generation of personalized mesenchymal stem cells |
| WO2025235862A1 (en) | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
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-
2011
- 2011-09-07 EP EP19181517.4A patent/EP3572501B1/en active Active
- 2011-09-07 JP JP2013527735A patent/JP6283223B2/ja active Active
- 2011-09-07 WO PCT/IL2011/000722 patent/WO2012032521A2/en not_active Ceased
- 2011-09-07 SG SG2013016365A patent/SG188411A1/en unknown
- 2011-09-07 DK DK11770876.8T patent/DK2614141T3/da active
- 2011-09-07 CA CA2810488A patent/CA2810488C/en active Active
- 2011-09-07 ES ES11770876T patent/ES2746482T3/es active Active
- 2011-09-07 CA CA3150342A patent/CA3150342A1/en active Pending
- 2011-09-07 SG SG10201509953VA patent/SG10201509953VA/en unknown
- 2011-09-07 SG SG10202109393R patent/SG10202109393RA/en unknown
- 2011-09-07 EP EP11770876.8A patent/EP2614141B1/en active Active
- 2011-09-07 SG SG10201800628QA patent/SG10201800628QA/en unknown
- 2011-09-07 US US13/821,244 patent/US10214722B2/en active Active
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2013
- 2013-03-06 IL IL225070A patent/IL225070B/en active IP Right Grant
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2017
- 2017-01-11 US US15/403,303 patent/US10597635B2/en active Active
- 2017-06-08 JP JP2017113227A patent/JP6574458B2/ja active Active
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2018
- 2018-08-05 US US16/055,110 patent/US11193108B2/en active Active
-
2019
- 2019-02-28 IL IL265107A patent/IL265107B/en active IP Right Grant
- 2019-08-16 JP JP2019149488A patent/JP2020000241A/ja active Pending
-
2020
- 2020-03-05 US US16/809,771 patent/US11959098B2/en active Active
- 2020-04-27 IL IL274282A patent/IL274282B/en unknown
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2021
- 2021-11-10 US US17/522,988 patent/US20220056406A1/en active Pending
- 2021-11-17 IL IL288185A patent/IL288185B2/en unknown
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2022
- 2022-01-20 JP JP2022007129A patent/JP7357086B2/ja active Active
-
2023
- 2023-09-25 JP JP2023161645A patent/JP7663644B2/ja active Active
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