JP2013536442A5 - - Google Patents
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- JP2013536442A5 JP2013536442A5 JP2013526167A JP2013526167A JP2013536442A5 JP 2013536442 A5 JP2013536442 A5 JP 2013536442A5 JP 2013526167 A JP2013526167 A JP 2013526167A JP 2013526167 A JP2013526167 A JP 2013526167A JP 2013536442 A5 JP2013536442 A5 JP 2013536442A5
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- JP
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- biological sample
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- 238000000034 method Methods 0.000 description 23
- 239000012472 biological sample Substances 0.000 description 14
- 108090000765 processed proteins & peptides Proteins 0.000 description 12
- 229920001184 polypeptide Polymers 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- 239000012634 fragment Substances 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 239000002157 polynucleotide Substances 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 208000002151 Pleural effusion Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000001138 tear Anatomy 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000009175 antibody therapy Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37738710P | 2010-08-26 | 2010-08-26 | |
| US61/377,387 | 2010-08-26 | ||
| PCT/US2011/049274 WO2012027631A2 (en) | 2010-08-26 | 2011-08-26 | Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536442A JP2013536442A (ja) | 2013-09-19 |
| JP2013536442A5 true JP2013536442A5 (enExample) | 2013-11-28 |
| JP6097688B2 JP6097688B2 (ja) | 2017-03-15 |
Family
ID=45724080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526167A Active JP6097688B2 (ja) | 2010-08-26 | 2011-08-26 | 抗ｈｅ４抗体を検出するための方法、ならびにｈｅ４発現細胞と関連する状態の診断および／または予後判定のための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20130224772A1 (enExample) |
| EP (1) | EP2609429B1 (enExample) |
| JP (1) | JP6097688B2 (enExample) |
| CN (1) | CN103180732B (enExample) |
| AU (1) | AU2011293217A1 (enExample) |
| BR (1) | BR112013004458A2 (enExample) |
| CA (1) | CA2809368C (enExample) |
| MX (1) | MX2013002268A (enExample) |
| RU (1) | RU2600891C2 (enExample) |
| WO (1) | WO2012027631A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| AU2011359350B2 (en) * | 2011-02-17 | 2016-07-14 | Fujirebio Diagnostics, Inc | Compositions and methods of use for determination of HE4a |
| CN103424551B (zh) * | 2013-08-06 | 2015-08-26 | 江苏福隆生物技术有限公司 | 人附睾上皮分泌蛋白4定量测定试剂盒及其检测方法 |
| US10267802B2 (en) * | 2015-09-23 | 2019-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of prognosis and diagnosis of ovarian cancer |
| CN108369233B (zh) * | 2015-12-17 | 2022-11-15 | 豪夫迈·罗氏有限公司 | 基于标志物人附睾蛋白4 (he4)检测肺腺癌的复发的方法及相关用途 |
| CN109280084B (zh) * | 2018-03-09 | 2022-04-29 | 河南大学 | 一种胶体硒标记的抗he4抗体、试剂盒及其制备方法 |
| CN109480771B (zh) * | 2018-10-17 | 2021-09-07 | 江西惠肽生物科技有限公司 | 一种卵巢肿块良恶的确定方法及确定装置 |
| CN110895279B (zh) * | 2019-11-27 | 2023-02-28 | 普健生物（武汉）科技有限公司 | 一种检测人附睾分泌蛋白4的化学发光试剂盒 |
| TW202300916A (zh) * | 2021-03-22 | 2023-01-01 | 美商治療股份有限公司 | 使用唾液或鼻腔檢體之免疫評估 |
| CN113045663B (zh) * | 2021-04-18 | 2022-04-01 | 深圳市国创纳米抗体技术有限公司 | 一种抗he4的纳米抗体1a8及其应用 |
| CN117487018B (zh) * | 2023-09-27 | 2024-05-17 | 武汉爱博泰克生物科技有限公司 | 抗人附睾分泌蛋白4的兔单克隆抗体及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017342A (en) * | 1988-06-01 | 1991-05-21 | Ortho Diagnostic Systems Inc. | Device for immunoassay determinations |
| WO2002046765A2 (en) * | 2000-11-08 | 2002-06-13 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
| US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| ATE503846T1 (de) * | 2005-09-15 | 2011-04-15 | Val Chum S E C | Verfahren zur diagnose eines ovarialkarzinoms |
| CN106124765A (zh) * | 2006-01-04 | 2016-11-16 | 富士瑞必欧美国公司 | He4与其它生化标记物在卵巢癌评估中的应用 |
| EP2062053B1 (en) * | 2006-09-13 | 2012-12-05 | Oncimmune LTD | Improved immunoassay methods |
| KR20100015438A (ko) * | 2007-03-09 | 2010-02-12 | 트리패스 이미징, 인코포레이티드 | Ｈｅ4 모노클로날 항체 및 이의 사용 방법 |
| CA2682132C (en) * | 2007-03-29 | 2022-03-22 | Fujirebio Diagnostics, Inc. | Use of he4 for assessment of breast cancers |
| WO2010061393A1 (en) * | 2008-11-30 | 2010-06-03 | Compugen Ltd. | He4 variant nucleotide and amino acid sequences, and methods of use thereof |
| CN101525614A (zh) * | 2009-04-13 | 2009-09-09 | 大连美亿德生物科技有限公司 | 人卵巢癌肿瘤标志物he4酶联免疫诊断试剂盒 |
-
2011
- 2011-08-26 US US13/818,466 patent/US20130224772A1/en not_active Abandoned
- 2011-08-26 BR BR112013004458A patent/BR112013004458A2/pt not_active IP Right Cessation
- 2011-08-26 RU RU2013113314/15A patent/RU2600891C2/ru active
- 2011-08-26 CA CA2809368A patent/CA2809368C/en active Active
- 2011-08-26 WO PCT/US2011/049274 patent/WO2012027631A2/en not_active Ceased
- 2011-08-26 CN CN201180051336.5A patent/CN103180732B/zh active Active
- 2011-08-26 AU AU2011293217A patent/AU2011293217A1/en not_active Abandoned
- 2011-08-26 JP JP2013526167A patent/JP6097688B2/ja active Active
- 2011-08-26 EP EP11820697.8A patent/EP2609429B1/en active Active
- 2011-08-26 MX MX2013002268A patent/MX2013002268A/es unknown
-
2018
- 2018-01-25 US US15/879,963 patent/US20180217158A1/en not_active Abandoned
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