CN103180732B - 检测抗he4抗体的方法以及诊断和/或预后与he4表达细胞相关的病症的方法 - Google Patents

检测抗he4抗体的方法以及诊断和/或预后与he4表达细胞相关的病症的方法 Download PDF

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Publication number
CN103180732B
CN103180732B CN201180051336.5A CN201180051336A CN103180732B CN 103180732 B CN103180732 B CN 103180732B CN 201180051336 A CN201180051336 A CN 201180051336A CN 103180732 B CN103180732 B CN 103180732B
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antibody
biological sample
antibodies
cancer
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CN103180732A (zh
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卡尔·埃里克·赫尔斯特罗姆
因格戈尔德·赫尔斯特罗姆
刘璞
嘉德·贾法尔
伊丽莎白·思惟舍尔
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University of Washington Center for Commercialization
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180051336.5A 2010-08-26 2011-08-26 检测抗he4抗体的方法以及诊断和/或预后与he4表达细胞相关的病症的方法 Active CN103180732B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37738710P 2010-08-26 2010-08-26
US61/377,387 2010-08-26
PCT/US2011/049274 WO2012027631A2 (en) 2010-08-26 2011-08-26 Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells

Publications (2)

Publication Number Publication Date
CN103180732A CN103180732A (zh) 2013-06-26
CN103180732B true CN103180732B (zh) 2017-09-08

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Country Link
US (2) US20130224772A1 (enExample)
EP (1) EP2609429B1 (enExample)
JP (1) JP6097688B2 (enExample)
CN (1) CN103180732B (enExample)
AU (1) AU2011293217A1 (enExample)
BR (1) BR112013004458A2 (enExample)
CA (1) CA2809368C (enExample)
MX (1) MX2013002268A (enExample)
RU (1) RU2600891C2 (enExample)
WO (1) WO2012027631A2 (enExample)

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US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
CA2827618C (en) * 2011-02-17 2019-08-06 Fujirebio Diagnostics, Inc. Compositions and methods of use for the determination of he4a
CN103424551B (zh) * 2013-08-06 2015-08-26 江苏福隆生物技术有限公司 人附睾上皮分泌蛋白4定量测定试剂盒及其检测方法
US10267802B2 (en) * 2015-09-23 2019-04-23 The Board Of Trustees Of The Leland Stanford Junior University Methods of prognosis and diagnosis of ovarian cancer
KR102599695B1 (ko) * 2015-12-17 2023-11-07 에프. 호프만-라 로슈 아게 마커 사람 부고환 단백질 4 (he4) 기반의 폐 선암 재발의 발견 방법 및 관련 용도
CN109280084B (zh) * 2018-03-09 2022-04-29 河南大学 一种胶体硒标记的抗he4抗体、试剂盒及其制备方法
CN109480771B (zh) * 2018-10-17 2021-09-07 江西惠肽生物科技有限公司 一种卵巢肿块良恶的确定方法及确定装置
CN110895279B (zh) * 2019-11-27 2023-02-28 普健生物（武汉）科技有限公司 一种检测人附睾分泌蛋白4的化学发光试剂盒
WO2022204017A1 (en) * 2021-03-22 2022-09-29 Curative Inc. Immunization assessments using saliva or nasal specimen
CN113045663B (zh) * 2021-04-18 2022-04-01 深圳市国创纳米抗体技术有限公司 一种抗he4的纳米抗体1a8及其应用
CN117487018B (zh) * 2023-09-27 2024-05-17 武汉爱博泰克生物科技有限公司 抗人附睾分泌蛋白4的兔单克隆抗体及其应用

Citations (4)

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US20020182619A1 (en) * 2000-11-08 2002-12-05 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
CN1813188A (zh) * 2001-08-29 2006-08-02 太平洋西北研究院 癌的诊断
CN101473041A (zh) * 2006-01-04 2009-07-01 富士瑞必欧美国公司 He4与其它生化标记物在评估子宫内膜癌和子宫癌中的应用
CN101525614A (zh) * 2009-04-13 2009-09-09 大连美亿德生物科技有限公司 人卵巢癌肿瘤标志物he4酶联免疫诊断试剂盒

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US5017342A (en) * 1988-06-01 1991-05-21 Ortho Diagnostic Systems Inc. Device for immunoassay determinations
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
EP1924710B1 (en) * 2005-09-15 2011-03-30 Val-Chum, S.E.C. Methods of diagnosing ovarian cancer
AU2007297310B2 (en) * 2006-09-13 2013-11-07 Oncimmune Limited Improved immunoassay methods
KR20100015438A (ko) * 2007-03-09 2010-02-12 트리패스 이미징, 인코포레이티드 Ｈｅ4 모노클로날 항체 및 이의 사용 방법
EP2126577B1 (en) * 2007-03-29 2013-03-13 Fujirebio Diagnostics, Inc. Use of he4 for assessment of breast cancers
WO2010061393A1 (en) * 2008-11-30 2010-06-03 Compugen Ltd. He4 variant nucleotide and amino acid sequences, and methods of use thereof

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US20020182619A1 (en) * 2000-11-08 2002-12-05 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
CN1813188A (zh) * 2001-08-29 2006-08-02 太平洋西北研究院 癌的诊断
CN101473041A (zh) * 2006-01-04 2009-07-01 富士瑞必欧美国公司 He4与其它生化标记物在评估子宫内膜癌和子宫癌中的应用
CN101525614A (zh) * 2009-04-13 2009-09-09 大连美亿德生物科技有限公司 人卵巢癌肿瘤标志物he4酶联免疫诊断试剂盒

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The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma;Ingegerd Hellstrom et al;《CANCER RESEARCH》;20030701;第63卷;3695-3700 *
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AU2011293217A1 (en) 2013-04-11
JP6097688B2 (ja) 2017-03-15
JP2013536442A (ja) 2013-09-19
EP2609429A2 (en) 2013-07-03
CN103180732A (zh) 2013-06-26
CA2809368C (en) 2021-08-24
US20180217158A1 (en) 2018-08-02
EP2609429B1 (en) 2017-09-20
CA2809368A1 (en) 2012-03-01
WO2012027631A3 (en) 2012-07-19
RU2600891C2 (ru) 2016-10-27
MX2013002268A (es) 2014-02-03
BR112013004458A2 (pt) 2016-06-07
WO2012027631A2 (en) 2012-03-01
RU2013113314A (ru) 2014-10-10
EP2609429A4 (en) 2014-03-19
US20130224772A1 (en) 2013-08-29

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