JP2012512389A5 - - Google Patents
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- JP2012512389A5 JP2012512389A5 JP2011540202A JP2011540202A JP2012512389A5 JP 2012512389 A5 JP2012512389 A5 JP 2012512389A5 JP 2011540202 A JP2011540202 A JP 2011540202A JP 2011540202 A JP2011540202 A JP 2011540202A JP 2012512389 A5 JP2012512389 A5 JP 2012512389A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- subject
- nucleic acid
- detection
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 55
- 206010028980 Neoplasm Diseases 0.000 claims description 26
- 201000011510 cancer Diseases 0.000 claims description 26
- 238000001514 detection method Methods 0.000 claims description 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 21
- 150000007523 nucleic acids Chemical class 0.000 claims description 19
- 210000001808 exosome Anatomy 0.000 claims description 13
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 229920001184 polypeptide Polymers 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 108091008874 T cell receptors Proteins 0.000 claims description 5
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 5
- 230000003321 amplification Effects 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 239000000090 biomarker Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 230000001747 exhibiting effect Effects 0.000 claims description 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 2
- 230000006866 deterioration Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0822836.3 | 2008-12-15 | ||
| GBGB0822836.3A GB0822836D0 (en) | 2008-12-15 | 2008-12-15 | Method |
| PCT/GB2009/002885 WO2010070276A1 (en) | 2008-12-15 | 2009-12-15 | Method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512389A JP2012512389A (ja) | 2012-05-31 |
| JP2012512389A5 true JP2012512389A5 (enExample) | 2012-11-22 |
| JP5671475B2 JP5671475B2 (ja) | 2015-02-18 |
Family
ID=40326133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540202A Expired - Fee Related JP5671475B2 (ja) | 2008-12-15 | 2009-12-15 | 方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120027749A1 (enExample) |
| EP (1) | EP2370818A1 (enExample) |
| JP (1) | JP5671475B2 (enExample) |
| CN (1) | CN102301236B (enExample) |
| GB (1) | GB0822836D0 (enExample) |
| WO (1) | WO2010070276A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| EP3181705A1 (en) | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| US20130052647A1 (en) * | 2010-02-10 | 2013-02-28 | Marianna Goldrick | Methods for fractionating and processing microparticles from biological samples and using them for biomarker discovery |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| KR20140067001A (ko) * | 2011-08-08 | 2014-06-03 | 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. | 생물지표 조성물 및 방법 |
| EP2758774A4 (en) * | 2011-09-22 | 2015-04-29 | Univ Los Andes | METHOD FOR MONITORING, DIAGNOSIS AND / OR FORECASTING ACUTE CHILDIER INJURY IN AN EARLY STAGE |
| JP6254951B2 (ja) * | 2012-01-24 | 2017-12-27 | ファイザー・インク | 哺乳類の対象における５ｔ４陽性循環腫瘍細胞を検出するための方法および５ｔ４陽性がんの診断の方法 |
| JP5969777B2 (ja) * | 2012-03-07 | 2016-08-17 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 肺腺扁平上皮癌の腫瘍マーカー及び診断キット |
| SG10201404895XA (en) * | 2014-08-13 | 2016-03-30 | Agency Science Tech & Res | Diagnosis |
| CN105388055B (zh) * | 2015-12-11 | 2018-03-27 | 浙江省肿瘤医院 | 从尿液中分离肿瘤细胞来源的外泌体的方法 |
| CN105505877B (zh) * | 2015-12-11 | 2018-09-28 | 浙江省肿瘤医院 | 恶性胸腔积液中分离肿瘤细胞来源的外泌体的方法 |
| WO2018075825A1 (en) * | 2016-10-19 | 2018-04-26 | Northwestern University | Extracellular vesicle-based diagnostics and engineered exosomes for targeted therapeutics against cancer |
| JP7007761B2 (ja) * | 2017-09-18 | 2022-03-04 | 国立台湾大学 | 甲状腺癌の予後のためのバイオマーカー |
| WO2021231720A1 (en) * | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Method of using extracellular vesicles to detect complement activation, and uses thereof to assess and/or monitor treatment of a complement-mediated disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0403559A1 (en) * | 1988-03-04 | 1990-12-27 | Cancer Research Campaign Technology Limited | Improvements relating to antigens |
| AU2001285157A1 (en) * | 2000-08-28 | 2002-03-13 | Oncomedx, Inc. | 5t4 rna in plasma and serum as a marker for neoplastic disease |
| SE0102327D0 (sv) * | 2001-06-28 | 2001-06-28 | Active Biotech Ab | A novel engineered superantigen for human therapy |
| DE102004038076A1 (de) * | 2004-02-16 | 2005-09-01 | Proteosys Ag | Diagnostische Marker für Krebs |
| WO2005078124A2 (de) * | 2004-02-16 | 2005-08-25 | Proteosys Ag | Diagnostische marker für krebs |
| DK1782070T3 (da) * | 2004-06-17 | 2011-01-03 | Mannkind Corp | Tumorassocieret antigenprofiler i cancerdiagnostik og immunterapi |
| TW200616662A (en) * | 2004-09-10 | 2006-06-01 | Wyeth Corp | Humanized anti-5t4 antibodies and anti-5t4 antibody/calicheamicin conjugates |
| EP1724585A1 (en) | 2005-05-21 | 2006-11-22 | ProteoSys AG | Annexin for cancer risk assessment |
| EP1724586A3 (en) * | 2005-05-21 | 2007-07-04 | ProteoSys AG | Annexin for cancer risk assessment |
| EP2604704B1 (en) * | 2008-02-01 | 2018-10-03 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of brain tumor |
| EP3181705A1 (en) * | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| GB201018480D0 (en) * | 2010-11-02 | 2010-12-15 | Oxford Biomedica Ltd | Factors |
-
2008
- 2008-12-15 GB GBGB0822836.3A patent/GB0822836D0/en active Pending
-
2009
- 2009-12-15 EP EP09795519A patent/EP2370818A1/en not_active Withdrawn
- 2009-12-15 CN CN200980155784.2A patent/CN102301236B/zh not_active Expired - Fee Related
- 2009-12-15 US US13/139,682 patent/US20120027749A1/en not_active Abandoned
- 2009-12-15 WO PCT/GB2009/002885 patent/WO2010070276A1/en not_active Ceased
- 2009-12-15 JP JP2011540202A patent/JP5671475B2/ja not_active Expired - Fee Related
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