CN105203763B - 一种口腔癌特异性检测的试剂盒 - Google Patents
一种口腔癌特异性检测的试剂盒 Download PDFInfo
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- CN105203763B CN105203763B CN201510775735.6A CN201510775735A CN105203763B CN 105203763 B CN105203763 B CN 105203763B CN 201510775735 A CN201510775735 A CN 201510775735A CN 105203763 B CN105203763 B CN 105203763B
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- Prior art keywords
- bpifb2
- aptamer
- oral cancer
- test kit
- dna
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4743—Bactericidal/Permeability-increasing protein BPI
Abstract
Description
名称 | 解离常数Kd(单位nM) |
BPIFB2-1 | 11.3 |
BPIFB2 -2 | 10.3 |
BPIFB2 -3 | 10.9 |
BPIFB2 -4 | 11.0 |
BPIFB2 -5 | 11.2 |
BPIFB2 -6 | 11.7 |
BPIFB2 -7 | 10.9 |
BPIFB2 -8 | 10.8 |
BPIFB2 -9 | 10.7 |
BPIFB2 -10 | 11.7 |
BPIFB2 -11 | 11.5 |
BPIFB2 -12 | 10.7 |
BPIFB2 -13 | 11.4 |
BPIFB2 -14 | 11.3 |
BPIFB2 -15 | 10.9 |
BPIFB2 -16 | 10.0 |
PBS空白对照 | 无结合能力 |
Claims (1)
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610505490.XA CN105929163A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504453.7A CN105891517A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505458.1A CN106053814A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504440.XA CN105891514A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504452.2A CN105891516A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504451.8A CN105891515A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503478.5A CN105891486A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503507.8A CN105911282A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505457.7A CN105954519A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504455.6A CN105891488A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503506.3A CN105911295A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505473.6A CN105954520A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505437.XA CN105891518A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503479.XA CN105891487A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201510775735.6A CN105203763B (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503476.6A CN105891513A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
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CN201510775735.6A CN105203763B (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
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CN201610504452.2A Division CN105891516A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505473.6A Division CN105954520A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503507.8A Division CN105911282A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504455.6A Division CN105891488A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505457.7A Division CN105954519A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505458.1A Division CN106053814A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504451.8A Division CN105891515A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505490.XA Division CN105929163A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504440.XA Division CN105891514A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503506.3A Division CN105911295A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503478.5A Division CN105891486A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504453.7A Division CN105891517A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505437.XA Division CN105891518A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503479.XA Division CN105891487A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503476.6A Division CN105891513A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
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CN201610503478.5A Pending CN105891486A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
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CN201610503476.6A Pending CN105891513A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
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CN201610505457.7A Pending CN105954519A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503506.3A Pending CN105911295A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
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CN201610504451.8A Pending CN105891515A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610503476.6A Pending CN105891513A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610504453.7A Pending CN105891517A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
CN201610505457.7A Pending CN105954519A (zh) | 2015-11-15 | 2015-11-15 | 一种口腔癌特异性检测的试剂盒 |
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CN106093434A (zh) * | 2016-06-19 | 2016-11-09 | 曹帅 | 一种用于肝癌检测的试剂盒 |
CN106018828A (zh) * | 2016-06-19 | 2016-10-12 | 曹帅 | 一种用于肠道疾病检测的试剂盒 |
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CN101014609A (zh) * | 2004-04-26 | 2007-08-08 | 阿切埃米克斯有限公司 | 免疫球蛋白e的特异性核酸配体及其作为过敏性疾病治疗的应用 |
EP1957672A2 (fr) * | 2005-10-28 | 2008-08-20 | Biomerieux Sa | Procede de detection du cancer |
US20100279419A1 (en) * | 2007-09-18 | 2010-11-04 | Board Of Regents Of The University Of Texas System | Detection of saliva proteins modulated secondary to ductal carcinoma in situ of the breast |
EP2535410A4 (en) * | 2010-02-12 | 2014-08-13 | Ribomic Inc | APTAMER FOR FGF2 AND USE THEREOF |
US20130116343A1 (en) * | 2010-04-21 | 2013-05-09 | Board Of Regents Of The University Of Texas System | Salivary Protein Markers for Detection of Breast Cancer |
WO2014159669A2 (en) * | 2013-03-14 | 2014-10-02 | Somalogic, Inc. | Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions |
CN104059982A (zh) * | 2014-07-04 | 2014-09-24 | 杨承刚 | 口腔癌致病基因bpifb2及其应用 |
CN104267185B (zh) * | 2014-09-12 | 2016-05-18 | 范飞舟 | 检测肿瘤的试剂盒及其专用识别n-乙酰氨基葡萄糖的物质 |
CN104818278A (zh) * | 2015-04-17 | 2015-08-05 | 刘红卫 | 能够特异性结合胃癌细胞中的ts/mdep蛋白的适配子 |
CN104830867A (zh) * | 2015-06-07 | 2015-08-12 | 杨洋 | 一种能够特异性结合癌细胞中的dkk1蛋白的适配子 |
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CN105891518A (zh) | 2016-08-24 |
CN105911295A (zh) | 2016-08-31 |
CN105891515A (zh) | 2016-08-24 |
CN105891488A (zh) | 2016-08-24 |
CN105891517A (zh) | 2016-08-24 |
CN105891514A (zh) | 2016-08-24 |
CN105954520A (zh) | 2016-09-21 |
CN105891513A (zh) | 2016-08-24 |
CN105203763A (zh) | 2015-12-30 |
CN105891487A (zh) | 2016-08-24 |
CN105911282A (zh) | 2016-08-31 |
CN105954519A (zh) | 2016-09-21 |
CN105891486A (zh) | 2016-08-24 |
CN106053814A (zh) | 2016-10-26 |
CN105891516A (zh) | 2016-08-24 |
CN105929163A (zh) | 2016-09-07 |
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