CN103562404A - 预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法 - Google Patents
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Abstract
本发明提供用于获得肝癌预后的标志物、用于获得肝癌预后的组合物或试剂盒以及用于获得肝癌预后的方法,所述组合物或试剂盒优选是能够在各个分期获得肝癌预后的肝癌预后组合物或试剂盒。本发明的标志物、组合物或试剂盒以及方法能够有效地获得肝癌预后、优选在各个分期有效地获得肝癌预后。
Description
技术领域
本发明涉及一种用于预测肝癌预后的生物标志物。更具体而言,本发明涉及一种预测肝癌预后的组合物或试剂盒及预测肝癌预后的方法。
背景技术
肝癌已知是世界上最致命的癌症之一。特别而言,据报道,在亚洲和撒哈拉以南的非洲每年有至少约50万人死于肝癌。肝癌大体上可以分为源于肝细胞本身的肝细胞癌和从其他组织传播到肝脏的转移性肝癌。至少约90%的肝癌是肝细胞癌,通常将术语“肝癌”理解为肝细胞癌。
肝癌预后是指对肝癌患者的多种状况的预估,例如从肝癌完全恢复的可能性、治疗后复发的可能性、诊断患有肝癌后患者存活的可能性等。其视不同条件(例如疾病的严重程度、诊断点、治疗进程等)而有所不同。肝癌仅在根据其预后来正确地使用各种治疗方法时能够得到高效地治疗。例如,对于被评估为预后良好的患者,有必要避免使用可能为患者带来严重副作用的危险治疗方法(例如攻击性的化学治疗或手术、放射治疗)而选择相对温和、保守和安全的治疗方法。另一方面,对于被评估为预后不佳的患者,为了延长生存期或提高生存率,应当积极地进行化学治疗或手术、诸如放射治疗等治疗方法。
根据迄今为止已进行的研究可知,对于已发生进展的肝癌,其预后非常差,并且显示出自诊断起6个月内死亡、平均存活期仅为4个月的高致死率。但是,尺寸小于3cm的肝癌却具有良好的预后,已知其在不进行任何特殊治疗时及在术后的1年内的生存率为90%,5年内的生存率为约40%~50%。然而,用现有技术来精确地预估肝癌预后是非常困难的。为了准确地预估预后,必须有一种将患者分类为各个风险组的分析方法。然而,迄今为止,预后仅仅是根据诊断时的临床病理学肝癌分期以及初步的外科手术治疗来确定,并不存在准确地预估肝癌预后的手段。
常规的分析方法包括BCLC(巴塞罗那临床肝癌)分期系统。该系统是通过在对患者进行外科手术前确定患者的肝癌分期来将肝癌患者分类从而确定治疗方法(肝脏切除、肝脏移植或射频消蚀等,视疾病分期而定)的系统(Llovert JM,Bru C,Bruix J.Prognosis of hepatocellular carcinoma:the BCLC staging classification.Semin Liver Dis.1999;19(3):329-338)。
然而,可惜的是,仅凭肝癌分期不能精确地确定每个肝癌患者的预后。因此,有必要开发一种使用基因标志物来对肝癌患者的预后进行精确预测的技术。即,基于每位个体患者的分期和预后结果来选择被预期为对特定治疗方法(例如,肝脏切除术)响应良好的患者,并向这些患者提供所述治疗,从而能够改进肝癌患者的整体治疗结果,并能够预期产生如节省医疗成本等社会经济效应。
同时,对于UVRAG、NAMPT、STAT3、CIAP2、BHLHE41、MMP2、SESN2、HMGB1、SIRT1、RPS19BP1、LAMP2、AGER、SESN3、ID2、TCF3、HMGB2、TP63、RAGE、KIAA1967、SATB1、RAPTOR、SESN1、CCNG2、CDH1、FASLG、CASP3、BECN1、CDH2、TWIST1、MMP9、VEGF、ATG12、DIABLO、E2F1、LAMP1、LC3、ATG7、TKT、AIFM1、BNIP3、ATG3、DRAM、ATG5、NNMT、PRKAA1、CASP8、ULK1、BCL2L1、FAS、CSE1L、FRAP1、AKT1、BAX、BCL2、PTEN、CBS、XIAP等蛋白,它们在肝癌组织中的表达水平或表达模式如何随肝癌的分期而变化,以及如何能够将它们用于根据分期来预测肝癌预后,都是已知的。虽然在一些情况下已使用上述蛋白或一些编码上述蛋白的基因来作为肝癌预后的标志物,但是尚无使用它们来作为根据分期来进行肝癌预后的标志物的情况。
在进行了有关预测肝癌预后的研究后,本发明人发现了表达水平和表达模式(根据肝癌的分期)发生显著变化的基因,并完成了本发明。
具体实施方式
技术主题
本发明所要解决的一个技术主题是提供一种用于预测肝癌预后的生物标志物,所述生物标志物能够(根据癌症的分期)对预后进行预测。
本发明所要解决的另一技术主题是提供一种用于预测肝癌预后的组合物或试剂盒,所述组合物或试剂盒能够(根据癌症的分期)对预后进行预测。
本发明所要解决的又一个技术主题是提供一种用于预测肝癌预后的方法,所述方法可以用来(根据癌症的分期)对预后进行预测。
实现主题的方法
本发明提供一种用于预测肝癌预后的生物标志物,优选是用于根据分期来预测肝癌预后的生物标志物,所述生物标志物是选自下表1所列的基因和这些基因所编码的蛋白中的至少一种。
[表1]
在上表中,NCBI GI(Geninfo标识符)是指由美国国家生物技术信息中心(NCBI)提供的序列识别号,其由登录号和版本号组成。
在本发明中,“肝癌”包括源于肝细胞本身的肝细胞癌和从其他组织传播到肝脏的转移性肝癌。优选的是,“肝癌”指肝细胞癌。
在本发明中,“用于预测肝癌预后的标志物”是指基因标志物,其作为在肝癌出现后预测肝癌预后的标准。该标志物具有显著低的p值,其中所述p值根据所述标志物在具有不同预后的患者的肝癌细胞和/或组织中的表达差异计算得到。优选的是,所述标志物的p值小于0.05。
此外,本发明提供用于预测肝癌预后的组合物或试剂盒,所述组合物或试剂盒包含:对选自表1所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸,或对所述基因编码的蛋白有特异性的抗体;且所述组合物或试剂盒用于根据选自下述各组的一个或多个组中的分期来预测肝癌预后:A1组{门静脉侵袭阴性患者组,患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期,具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤},A2组{门静脉侵袭阴性患者组,患者具有尺寸大于5cm的肿瘤},B组{门静脉侵袭阴性患者组,患者处于BCLC分期系统的中期,具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤},或C组{门静脉侵袭阳性患者组,不论肿瘤尺寸和数量如何}。
所述至少两种基因可以是至少三种、四种、五种、六种、七种或八种以上基因。
优选的是,由基因组成的所述组可以是下表2所示的基因组成的组。
[表2]
更优选的是,由基因组成的所述组还可以包含下表3所示的基因。
[表3]
在上表2所示的基因中,CDH1、ID2、MMP9、TCF3可以从表2中排除,并且可以进一步包含在表3所示的基因的组中。
BCLC分类(即,图1中所用的分类)是通过在对肝癌患者进行外科手术前确定肝癌的分期来将肝癌患者分类从而确定治疗方法(肝脏切除、肝脏移植或射频消蚀等,视分期而定)的系统(Llovert JM,Bru C,Bruix J.Prognosis of hepatocellular carcinoma:the BCLC staging classification.Semin Liver Dis.1999;19(3):329-338)。在图1中,体力状态测试(PST)分为阶段0~阶段4。阶段0是指体力无问题的情况;阶段1是指患者能够进行轻度工作的情况;阶段2是指患者不能工作但可以照料自己的情况;阶段3是指患者能够有限地照料自己且日常生活的至少50%是在床上或椅上度过的阶段;阶段4是指患者不能进行任何活动、不能照料自己且全天都在床上或椅上度过的情况。在Okuda分期中,各期基于四种标准来确定,并根据癌的尺寸大于还是小于整个肝脏的50%、根据是否存在腹水并根据胆红素数值(小于或大于3mg/dL)和白蛋白数值(小于或大于3g/dL)来将这些期分类为I期、II期、III期。Child-Pugh分级是评估肝硬化患者的肝功的指数。评估了白蛋白值(>3.5g/dL:1分;2.8~3.5g/dL:2分;<2.8g/dL:3分)、胆红素值(<2.0mg/dL:1分;2.0~3.0mg/dL:2分;>3.0mg/dL:3分)、凝血酶原时间值(>50%:1分;40%~50%:2分;<40%:3分)、腹水的存在(无:1分;略有:2分;中等:3分)、脑病分级(无:1分;不确定的脾气变化、抑郁、震颤、嗜睡、讲话缓慢且口齿不清、扑翼样震颤、行走困难:2分;肌肉僵直、失定向、意识错乱、间歇性肌痛性痉挛、眼球震颤、昏迷、瞳孔散大、去大脑动物姿势:3分)等。6分以下为A类,7~9分为B类,10分以上为C类。
以上预后能够预示复发、存活或无病存活,并且可以作为进行了癌症肝脏切除术后的预后。“复发”指的是进行了癌症肝脏切除术后的存活者的肝癌复发。“存活”是指在癌症肝脏切除术后5年内的存活率。无病存活是指进行癌症肝脏切除术后无复发的存活。
优选的是,所述组合物或试剂盒用于预测A1组的复发预后,并且所述基因是选自下表4所示的基因或基因的组中的一种或多种。
[表4]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
BCL2L1 | FRAP1_SESN1 | FRAP1_CASP3_CDH2 | ID2_NAMPT_RPS19BP1_SESN3 |
BECN1 | FRAP1_TWIST1 | ID2_CDH2_SESN3 | FRAP1_LC3_CASP3_CDH2 |
BAX | FRAP1_CASP3 | FRAP1_CDH2_SESN1 | FRAP1_TKT_CASP3_CDH2 |
CDH2 | FRAP1_CCNG2 | FRAP1_LC3_CASP3 | BAX_FRAP1_LC3CDH2 |
NAMPT | BAX_FRAP1 | FRAP1_LC3_TWIST1 | ID2_CDH2_NAMPT_SESN3 |
TWIST1 | FRAP1_NNMT | BAX_FRAP1_LC3 | CBS_ID2_CDH2_SESN3 |
RPS19BP1 | BCL2L1_FRAP1 | FRAP1_CDH2_TWIST1 | FRAP1_LC3_CDH2_KIAA1967 |
MMP2 | AIFM1_FRAP1 | FRAP1_NNMT_CDH2 | FRAP1_CDH2_SESN1_STAT3 |
SESN3 | FRAP1_RAGE | FRAP1_LC3_NNMT | FRAP1_LC3_NNMT_CDH2 |
ID2 | FRAP1_VEGF | BAX_FRAP1_CDH2 | FRAP1_LC3_CDH2_RAPTOR |
AGER | ID2_CDH2 | FRAP1_SESN1_STAT3 | ID2_CDH2_RPS19BP1_SESN3 |
ATG12 | FRAP1_PTEN | AIFM1_FRAP1_CDH2 | FRAP1_LC3_CDH2_TWIST1 |
NAMPT_SESN3 | FRAP1_LC3_VEGF | FRAP1_LC3_CDH2_VEGF | |
BCL2_FRAP1 | FRAP1_NNMT_MMP2 | FRAP1_LC3_SESN1_STAT3 | |
CDH2_SESN3 | FRAP1_LC3_RAGE | FRAP1_LC3_CDH2_RAGE | |
FRAP1_RAPTOR | FRAP1_CCNG2_CDH2 | FRAP1_LC3_NNMT_STAT3 | |
FRAP1_KIAA1967 | BCL2L1_FRAP1_CDH2 | ID2_CDH2_MMP2_SESN3 | |
FRAP1_XIAP | FRAP1_CDH2_VEGF | FRAP1_LC3_CASP3_STAT3 | |
BECN1_SESN3 | FRAP1_LC3_CCNG2 | AIFM1_FRAP1_LC3_CDH2 | |
HMGB1_TWIST1 | FRAP1_CASP3_MMP2 | BCL2L1_FRAP1_LC3_CDH2 | |
ID2_NAMPT | BCL2L1_FRAP1_LC3 | FRAP1_LC3_PTEN_CDH2 | |
FRAP1_PRKAA1 | FRAP1_LC3_SESN1 | BAX_FRAP1_LC3_BECN1 | |
ID2_RPS19BP1 | FRAP1_CDH2_KIAA1967 | BAX_FRAP1_LC3_RPS19BP1 | |
BAX_LC3 | AIFM1_FRAP1_LC3 | FRAP1_CASP3_CDH2_STAT3 | |
FRAP1_TP63 | FRAP1_LC3_RAPTOR | LC3_HMGB1_STAT3_TWIST1 | |
ATG12_SESN3 | FRAP1_CDH2_RAGE | BAX_FRAP1_TKT_CDH2 | |
BAX_TWIST1 | BAX_FRAP1_MMP2 | FRAP1_LC3_CCNG2_CDH2 | |
RPS19BP1_SESN3 | FRAP1_LC3_PTEN | FRAP1_TKT_CDH2_SESN1 | |
BAX_MMP2 | FRAP1_TKT_CASP3 | FRAP1_LC3_HMGB1_TWIST1 | |
SESN1_STAT3 | FRAP1_PTEN_CDH2 | FRAP1_NNMT_TKT_CDH2 | |
LC3_TWIST1 | FRAP1_TKT_TWIST1 | BAX_FRAP1_LC3_MMP2 |
MMP2_NAMPT | FRAP1_LC3_KIAA1967 | FRAP1_LC3_CCNG2_STAT3 | |
ID2_BECN1 | BAX_FRAP1_TKT | FRAP1_LC3_STAT3_TWIST1 | |
BCL2L1_LC3 | BCL2_FRAP1_CDH2 | FRAP1_TKT_CDH2_TWIST1 | |
MMP2_RPS19BP1 | FRAP1_HMGB1_TWIST1 | FRAP1_LC3_NNMT_MMP2 | |
ATG7_BCL2L1 | FRAP1_RPS19BP1_TWIST1 | BAX_FRAP1_TKT_MMP2 | |
ID2_TWIST1 | FRAP1_CDH2_RAPTOR | FRAP1_NNMT_CDH2_MMP2 | |
CDH2_HMGB1 | FRAP1_TKT_SESN1 | FRAP1_LC3_CDH2_SESN1 | |
CDH2_MMP2 | FRAP1_RPS19BP1_SESN1 | BAX_FRAP1_LC3_TKT | |
ATG7_TWIST1 | BAX_FRAP1_BECN1 | FAS_FRAP1_CDH2_SESN1 | |
BAX_SESN3 | ID2_NAMPT_SESN3 | BAX_FAS_FRAP1_LC3 | |
FASLG_NAMPT | FRAP1_CCNG2_STAT3 | FRAP1_CASP3_CDH2_MMP2 | |
ATG7_BAX | BCL2L1_FRAP1_MMP2 | ID2_FASLG_NAMPT_SESN3 | |
TKT_NAMPT | BCL2_FRAP1_LC3 | FRAP1_ID2_CDH2_TWIST1 | |
STAT3_TWIST1 | FASLG_NAMPT_SESN3 | FRAP1_CDH2_HMGB1_TWIST1 | |
BCL2L1_MMP2 | AIFM1_FRAP1_MMP2 | BAX_FRAP1_BECN1_CDH2 | |
LC3_KIAA1967 | FRAP1_CCNG2_RPS19BP1 | DRAM_ID2_CDH2_SESN3 | |
BAX_BECN1 | BAX_FRAP1_RPS19BP1 | FRAP1_LC3_RPS19BP1_TWIST1 | |
ATG12_ID2 | FAS_FRAP1_SESN1 | AIFM1_FRAP1_TKT_CDH2 | |
BECN1_MMP2 | BCL2L1_FRAP1_TKT | FRAP1_TKT_CCNG2_CDH2 | |
AKT1_BAX | FRAP1_NNMT_STAT3 | BCL2L1_FRAP1_TKT_CDH2 | |
LC3_RAPTOR | FRAP1_MMP2_SESN1 | DIABLO_ID2_CDH2_SESN3 | |
BAX_RPS19BP1 | FRAP1_ID2_TWIST1 | BCL2_FRAP1_LC3_CDH2 | |
BAX_TKT | FRAP1_CASP3_STAT3 | FRAP1_LC3_CASP3_FASLG | |
BAX_SATB1 | FRAP1_TKT_CCNG2 | FRAP1_CDH2_RPS19BP1_SESN1 | |
LC3_NAMPT | FRAP1_MMP2_VEGF | FRAP1_LC3_CASP3_MMP2 | |
KIAA1967_MMP2 | FRAP1_MMP2_RAPTOR | ID2_CDH2_HMGB2_SESN3 | |
CDH1_ID2_MMP9_TCF3 |
五种的组合 | 六种的组合 |
FRAP1_LC3_CASP3_CDH2_STAT3 | FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 |
ID2_MMP2_NAMPT_RPS19BP1_SESN3 | FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 |
FRAP1_LC3_CDH2_SESN1_STAT3 | FRAP1_LC3_TKT_CASP3_CDH2_STAT3 |
ID2_CDH2_MMP2_RPS19BP1_SESN3 | ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3 |
FRAP1_LC3_NNMT_CDH2_STAT3 | FAS_FRAP1_LC3_CDH2_SESN1_STAT3 |
BAX_FRAP1_LC3_BECN1_CDH2 | ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3 |
ID2_FASLG_NAMPT_RPS19BP1_SESN3 | FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3 |
BAX_FRAP1_LC3_TKT_CDH2 | FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 |
FRAP1_LC3_BECN1_CDH2_RAPTOR | FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 |
FRAP1_LC3_CDH2_STAT3_TWIST1 | FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1 |
FRAP1_LC3_CCNG2_CDH2_STAT3 | ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 |
ID2_CDH2_FASLG_NAMPT_SESN3 | AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3 |
LC3_CDH2_HMGB1_STAT3_TWIST1 | ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3 |
ID2_CDH2_HMGB1_RPS19BP1_SESN3 | ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3 |
ID2_CDH2_MMP2_NAMPT_SESN3 | AKT1_FAS_BECN1_CDH2_STAT3_TP63 |
FRAP1_LC3_BECN1_CDH2_KIAA1967 | FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 |
BAX_FRAP1_LC3_CDH2_RPS19BP1 | AKT1_ATG12_BECN1_CDH2_STAT3_TP63 |
ID2_HMGB2_NAMPT_RPS19BP1_SESN3 | FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 |
ID2_NAMPT_RPS19BP1_SESN3_STAT3 | CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3 |
FRAP1_LC3_CDH2_HMGB1_TWIST1 | FRAP1_LC3_BECN1_CDH2_RAGE_STAT3 |
FRAP1_TKT_CDH2_SESN1_STAT3 | FAS_FRAP1_LC3_NNMT_CDH2_STAT3 |
CSE1L_ID2_CDH2_RPS19BP1_SESN3 | ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 |
FRAP1_LC3_TKT_CASP3_CDH2 | FRAP1_LC3_TKT_CDH2_SESN1_STAT3 |
BAX_FAS_FRAP1_LC3_CDH2 | FRAP1_LC3_NNMT_CDH2_MMP2_STAT3 |
FAS_FRAP1_LC3_CDH2_RAPTOR | FRAP1_LC3_NNMT_TKT_CDH2_STAT3 |
LC3_CASP3_CDH2_HMGB1_STAT3 | BAX_FRAP1_LC3_BECN1_CDH2_STAT3 |
FAS_FRAP1_LC3_CDH2_KIAA1967 | FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3 |
AIFM1_FRAP1_LC3_CDH2_STAT3 | FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 |
FRAP1_LC3_BECN1_CASP3_STAT3 | CBS_FRAP1_LC3_CASP3_CDH2_STAT3 |
FRAP1_BECN1_CASP3_CDH2_STAT3 | FAS_FRAP1_LC3_CASP3_CDH2_STAT3 |
ID2_CDH2_NAMPT_SESN3_STAT3 | AKT1_ATG12_FAS_CDH2_STAT3_TP63 |
LC3_ID2_NAMPT_RPS19BP1_SESN3 | LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 |
FRAP1_LC3_NNMT_MMP2_STAT3 | FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1 |
BAX_FRAP1_LC3_CASP3_CDH2 | FRAP1_LC3_CASP3_CDH2_MMP2_STAT3 |
FRAP1_TKT_CASP3_CDH2_STAT3 | ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3 |
LC3_HMGB1_RPS19BP1_STAT3_TWIST1 | CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
FRAP1_CDH2_RPS19BP1_SESN1_STAT3 | FRAP1_LC3_BECN1_CDH2_STAT3_VEGF |
CBS_FRAP1_LC3_CASP3_CDH2 | BAX_FRAP1_LC3_TKT_BECN1_CDH2 |
FRAP1_LAMP1_TKT_CASP3_CDH2 | FRAP1_LC3_NNMT_CASP3_CDH2_STAT3 |
ID2_CDH2_HMGB1_NAMPT_SESN3 | FRAP1_TKT_BECN1_CASP3_CDH2_STAT3 |
ID2_HMGB1_NAMPT_RPS19BP1_SESN3 | ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 |
AKT1_ID2_NAMPT_RPS19BP1_SESN3 | FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1 |
FRAP1_LC3_TKT_CDH2_KIAA1967 | FRAP1_LC3_BECN1_CDH2_SESN1_STAT3 |
FRAP1_LC3_CASP3_CDH2_HMGB1 | ID2_CDH2_FASLG_NAMPT_SESN3_STAT3 |
ATG7_FRAP1_LC3_CASP3_CDH2 | FRAP1_LC3_TKT_CDH2_STAT3_TWIST1 |
BAX_FRAP1_LC3_TKT_MMP2 | ATG5_FRAP1_LC3_CASP3_CDH2_STAT3 |
FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 | ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3 |
FRAP1_LC3_RPS19BP1_SESN1_STAT3 | FAS_LC3_CDH2_HMGB1_STAT3_TWIST1 |
BAX_FRAP1_LC3_CDH2_MMP2 | AIFM1_FRAP1_LC3_TKT_CDH2_STAT3 |
ID2_TCF3_CDH2_RPS19BP1_SESN3 | FRAP1_LC3_TKT_CASP3_CDH2_FASLG |
FRAP1_TKT_CASP3_CDH2_FASLG | DRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3 |
FAS_FRAP1_CDH2_SESN1_STAT3 | FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3 |
CBS_ID2_NAMPT_RPS19BP1_SESN3 | FAS_FRAP1_LC3_CCNG2_CDH2_STAT3 |
FRAP1_LC3_CDH2_KIAA1967_MMP2 | BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1 |
FAS_FRAP1_LC3_CASP3_CDH2 | BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3 |
BAX_CBS_FRAP1_LC3_CDH2 | FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1 |
FRAP1_LC3_TKT_CDH2_RAPTOR | FRAP1_LC3_MMP9_CASP3_CDH2_STAT3 |
CDH1_ID2_MMP9_TCF3_RPS19BP1 | CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3 |
七种的组合 | 八种的组合 |
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 | AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 | AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 | AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63 |
AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 |
ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 | AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63 |
FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3 | AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 | AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 | FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 |
FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 | AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3 | FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3 |
ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 | CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 |
FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3 | AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 | FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3 |
FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3 | AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 | FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3 |
FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3 | AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 |
FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1 | AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 | AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 |
CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 | ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3 |
FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3 | AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63 |
AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 |
FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1 | ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 |
AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 | AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 |
FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3 | AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63 |
ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 | AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 | AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3 | AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63 |
CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 | AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1 | FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3 |
CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3 | AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63 |
FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3 | AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63 |
AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 | AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63 |
ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3 | FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3 |
ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3 | FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3 |
FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 | FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3 |
FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1 | FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3 |
FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 | AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3 | AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 |
BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 | AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 |
FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3 | FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3 |
FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 | FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3 |
ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 | AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR | CSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 |
FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3 | FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1 |
FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 | AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3 | FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1 |
FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 | FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3 |
AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3 | ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3 |
AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 | FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1 |
AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 | CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 |
ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 | FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3 |
AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 | FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3 |
AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 | FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR |
ATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 | AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63 |
FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3 | FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3 |
CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 | CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3 |
优选的是,所述组合物或试剂盒用于预测A1组的存活预后,并且所述基因是选自下表5所示的基因或基因的组中的一种或多种。
[表5]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
ID2 | CDH1_ID2 | ATG12_CDH1_ID2 | ATG12_CDH1_ID2_HMGB2 |
CDH1 | ATG12_CDH1 | CDH1_ID2_HMGB2 | CDH1_ID2_AGER_HMGB2 |
LC3 | LAMP1_ID2 | ATG12_CDH1_HMGB2 | ATG12_CDH1_ID2_AGER |
TKT | BNIP3_ID2 | CDH1_ID2_AGER | ATG12_CDH1_TCF3_HMGB2 |
AKT1 | ATG12_ID2 | DRAM_CDH1_ID2 | ATG12_DRAM_CDH1_ID2 |
AIFM1 | CDH1_HMGB2 | E2F1_CDH1_ID2 | AIFM1_CASP8_LC3_CDH1 |
BNIP3 | ID2_HMGB2 | CDH1_ID2_LAMP2 | ATG12_CDH1_AGER_HMGB2 |
LAMP1 | E2F1_ID2 | TKT_CDH1_ID2 | ATG12_CDH1_ID2_BECN1 |
FRAP1 | TKT_ID2 | LAMP1_CDH1_ID2 | ATG12_DRAM_CDH1_HMGB2 |
DRAM_ID2 | CDH1_ID2_MMP2 | DRAM_CDH1_ID2_HMGB2 | |
ATG5_ID2 | ATG12_DRAM_CDH1 | ATG12_CDH1_BHLHE41_HMGB2 | |
ID2_BECN1 | CSE1L_CDH1_ID2 | CDH1_ID2_HMGB2_LAMP2 | |
ID2_AGER | CDH1_ID2_MMP9 | ATG12_CDH1_BECN1_HMGB2 | |
ID2_MMP2 | BNIP3_CDH1_ID2 | E2F1_CDH1_ID2_HMGB2 | |
ATG3_ID2 | CDH1_ID2_BECN1 | ATG12_DIABLO_CDH1_BHLHE41 | |
ID2_LAMP2 | ATG12_CDH1_BHLHE41 | CDH1_ID2_BECN1_HMGB2 | |
ULK1_CDH1 | ULK1_CDH1_ID2 | ATG12_ATG5_CDH1_HMGB2 | |
CSE1L_ID2 | LC3_CDH1_ID2 | DRAM_CDH1_ID2_AGER | |
TKT_CDH1 | ATG12_CDH1_TCF3 | LAMP1_CDH1_ID2_HMGB2 | |
LC3_CDH1 | ATG5_CDH1_ID2 | ATG12_BNIP3_CDH1_ID2 | |
ID2_MMP9 | ATG3_CDH1_ID2 | ATG12_CSE1L_CDH1_ID2 | |
LC3_ID2 | DIABLO_CDH1_ID2 | ATG12_CDH1_ID2_MMP2 | |
FRAP1_ID2 | CASP8_CDH1_ID2 | ATG12_CASP8_CDH1_ID2 | |
CASP8_ID2 | ATG12_ULK1_CDH1 | ATG12_ATG3_CDH1_HMGB2 | |
ID2_CIAP2 | ATG12_CDH1_BECN1 | ATG12_CDH1_ID2_MMP9 |
ID2_UVRAG | ATG12_BNIP3_ID2 | CDH1_ID2_HMGB2_MMP2 | |
DIABLO_ID2 | CDH1_ID2_CIAP2 | ATG12_ATG3_CDH1_ID2 | |
DRAM_CDH1 | CBS_CDH1_ID2 | ATG12_CASP8_CDH1_HMGB2 | |
ID2_SIRT1 | CDH1_ID2_HMGB1 | ATG12_LAMP1_CDH1_ID2 | |
FAS_ID2 | CDH1_ID2_SIRT1 | CDH1_ID2_AGER_BECN1 | |
CDH1_AGER | LAMP1_ID2_HMGB2 | ATG12_FAS_CDH1_HMGB2 | |
ID2_STAT3 | CDH1_ID2_UVRAG | ATG12_TKT_CDH1_ID2 | |
CBS_ID2 | AIFM1_LC3_CDH1 | CDH1_ID2_MMP9_HMGB2 | |
CDH1_MMP2 | ATG12_CDH1_AGER | ATG12_CDH1_HMGB1_HMGB2 | |
AKT1_ID2 | CDH1_ID2_STAT3 | ATG12_CDH1_MMP9_HMGB2 | |
ID2_CDH2 | ATG12_LAMP1_ID2 | ATG12_ATG5_CDH1_ID2 | |
ATG7_ID2 | ATG12_LC3_CDH1 | ATG5_CDH1_ID2_HMGB2 | |
ID2_HMGB1 | CDH1_AGER_HMGB2 | ATG3_CDH1_ID2_HMGB2 | |
ULK1_ID2 | FAS_CDH1_ID2 | ATG12_DIABLO_CDH1_ID2 | |
CDH1_LAMP2 | ATG7_CDH1_ID2 | CSE1L_CDH1_ID2_HMGB2 | |
ATG5_CDH1 | ATG12_CDH1_MMP2 | ATG12_CDH1_CIAP2_HMGB2 | |
ID2_SATB1 | ATG12_CASP8_CDH1 | ATG12_CDH1_ID2_UVRAG | |
CDH1_MMP9 | ATG12_TKT_CDH1 | ATG12_CDH1_HMGB2_SESN3 | |
ID2_RPS19BP1 | BNIP3_ID2_HMGB2 | LC3_CDH1_ID2_AGER | |
ID2_TCF3 | E2F1_ID2_HMGB2 | ATG12_CDH1_HMGB2_SIRT1 | |
CSE1L_CDH1 | ATG12_CDH1_MMP9 | ATG12_E2F1_CDH1_ID2 | |
AIFM1_CDH1 | ATG12_CDH1_SESN2 | ATG12_FAS_CDH1_ID2 | |
ID2_SESN3 | CDH1_ID2_CDH2 | AIFM1_ATG3_LC3_CDH1 | |
ID2_SESN2 | AKT1_CDH1_ID2 | ATG12_CDH1_HMGB2_MMP2 | |
LAMP1_CDH1 | LAMP1_ID2_BECN1 | BNIP3_CDH1_ID2_HMGB2 | |
AIFM1_LC3 | CDH1_ID2_TCF3 | ATG12_ULK1_CDH1_HMGB2 | |
E2F1_CDH1 | ATG12_CDH1_UVRAG | TKT_CDH1_ID2_HMGB2 | |
ID2_NAMPT | ATG12_FAS_CDH1 | ATG12_CDH1_ID2_LAMP2 | |
DIABLO_CDH1 | LAMP1_TKT_ID2 | ATG12_LC3_CDH1_ID2 | |
BNIP3_CDH1 | LAMP1_ID2_AGER | ATG12_CDH1_HMGB2_UVRAG | |
AKT1_CDH1 | DRAM_LAMP1_ID2 | CASP8_CDH1_ID2_HMGB2 | |
CASP8_CDH1 | ATG12_DIABLO_CDH1 | DIABLO_CDH1_ID2_HMGB2 | |
CDH1_ID2_MMP9_TCF3 |
五种的组合 | 六种的组合 |
ATG12_CDH1_ID2_AGER_HMGB2 | ATG12_DRAM_CDH1_ID2_AGER_HMGB2 |
ATG12_DRAM_CDH1_ID2_HMGB2 | ATG12_CDH1_ID2_AGER_BECN1_HMGB2 |
DRAM_CDH1_ID2_AGER_HMGB2 | ATG12_CSE1L_CDH1_ID2_AGER_HMGB2 |
ATG12_CDH1_ID2_BECN1_HMGB2 | ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1 |
ATG12_LAMP1_CDH1_ID2_HMGB2 | ATG12_LAMP1_CDH1_ID2_AGER_HMGB2 |
ATG12_ATG5_CDH1_ID2_HMGB2 | ATG12_CDH1_ID2_MMP9_AGER_HMGB2 |
ATG12_E2F1_CDH1_ID2_HMGB2 | ATG12_ATG3_CDH1_ID2_AGER_HMGB2 |
ATG12_ATG3_CDH1_ID2_HMGB2 | ATG12_LC3_CDH1_ID2_AGER_HMGB2 |
CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_BNIP3_CDH1_ID2_AGER_HMGB2 |
ATG12_CDH1_ID2_HMGB2_MMP2 | ATG12_CDH1_ID2_AGER_HMGB2_SIRT1 |
ATG12_CASP8_CDH1_ID2_HMGB2 | ATG12_CDH1_ID2_AGER_HMGB2_MMP2 |
ATG12_BNIP3_CDH1_ID2_HMGB2 | ATG12_CASP8_CDH1_ID2_AGER_HMGB2 |
ATG12_CDH1_ID2_MMP9_HMGB2 | ATG12_CDH1_ID2_AGER_CIAP2_HMGB2 |
LAMP1_CDH1_ID2_AGER_HMGB2 | ATG12_ATG5_CDH1_ID2_AGER_HMGB2 |
ATG12_CSE1L_CDH1_ID2_HMGB2 | ATG12_CDH1_ID2_TCF3_AGER_HMGB2 |
LC3_CDH1_ID2_AGER_HMGB2 | ATG12_DRAM_CDH1_ID2_BECN1_HMGB2 |
ATG12_DIABLO_CDH1_ID2_HMGB2 | ATG12_FAS_CDH1_ID2_AGER_HMGB2 |
CSE1L_CDH1_ID2_AGER_HMGB2 | ATG12_CDH1_ID2_AGER_HMGB1_HMGB2 |
CDH1_ID2_MMP9_AGER_HMGB2 | ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2 |
CDH1_ID2_AGER_HMGB2_RPS19BP1 | ATG12_ATG3_DRAM_CDH1_ID2_HMGB2 |
ATG12_CDH1_ID2_CIAP2_HMGB2 | ATG12_ATG5_DRAM_CDH1_ID2_HMGB2 |
ATG12_CDH1_ID2_HMGB2_UVRAG | ATG12_DIABLO_CDH1_ID2_AGER_HMGB2 |
ATG12_DRAM_CDH1_ID2_AGER | ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 |
ATG12_DRAM_CDH1_TCF3_HMGB2 | ATG12_CASP8_DRAM_CDH1_ID2_HMGB2 |
ATG12_CDH1_ID2_AGER_BECN1 | ATG12_DRAM_CDH1_ID2_HMGB2_MMP2 |
ATG12_DIABLO_CDH1_BHLHE41_HMGB2 | ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2 |
ATG12_DIABLO_CDH1_HMGB2_SESN3 | ATG12_CBS_CDH1_ID2_AGER_HMGB2 |
ATG12_FAS_CDH1_ID2_HMGB2 | ATG12_DRAM_CDH1_ID2_MMP9_HMGB2 |
ATG3_CDH1_ID2_AGER_HMGB2 | ATG12_CDH1_ID2_AGER_HMGB2_UVRAG |
CDH1_ID2_AGER_HMGB2_MMP2 | ATG12_E2F1_CDH1_ID2_AGER_HMGB2 |
ATG12_CDH1_ID2_TCF3_HMGB2 | ATG12_ATG5_CDH1_ID2_BECN1_HMGB2 |
ATG12_CDH1_TCF3_AGER_HMGB2 | ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3 |
ATG12_CDH1_ID2_HMGB1_HMGB2 | ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2 |
AIFM1_ATG3_CASP8_LC3_CDH1 | ATG12_DRAM_E2F1_CDH1_ID2_HMGB2 |
ATG12_CDH1_ID2_HMGB2_SIRT1 | ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3 |
ATG12_CDH1_TCF3_BECN1_HMGB2 | AIFM1_ATG3_ATG5_CASP8_LC3_CDH1 |
ATG12_DIABLO_CDH1_TCF3_BHLHE41 | ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2 |
BNIP3_CDH1_ID2_AGER_HMGB2 | ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3 |
AIFM1_CASP8_DRAM_LC3_CDH1 | AIFM1_ATG3_CASP8_LC3_CDH1_MMP9 |
ATG12_CDH1_ID2_HMGB2_LAMP2 | ATG12_ATG3_CDH1_ID2_BECN1_HMGB2 |
ATG12_ATG3_CDH1_TCF3_HMGB2 | ATG12_CDH1_ID2_AGER_HMGB2_STAT3 |
ATG12_LC3_CDH1_ID2_HMGB2 | ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2 |
ATG12_TKT_CDH1_ID2_HMGB2 | ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2 |
CASP8_CDH1_ID2_AGER_HMGB2 | DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 |
ATG12_CDH1_TCF3_BHLHE41_HMGB2 | DRAM_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG5_CDH1_ID2_AGER_HMGB2 | ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2 |
ATG12_CSE1L_CDH1_ID2_AGER | ATG12_BNIP3_CDH1_ID2_BECN1_HMGB2 |
CDH1_ID2_AGER_HMGB2_SIRT1 | ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2 |
CDH1_ID2_AGER_CIAP2_HMGB2 | LAMP1_LC3_CDH1_ID2_AGER_HMGB2 |
CDH1_ID2_TCF3_AGER_HMGB2 | ATG12_CDH1_ID2_BECN1_HMGB2_MMP2 |
AIFM1_CASP8_LC3_CDH1_MMP9 | DRAM_LC3_CDH1_ID2_AGER_HMGB2 |
ATG12_DRAM_CDH1_ID2_BECN1 | ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1 |
AIFM1_CASP8_DIABLO_LC3_CDH1 | ATG12_TKT_CDH1_ID2_AGER_HMGB2 |
CDH1_ID2_AGER_HMGB1_HMGB2 | DRAM_CDH1_ID2_MMP9_AGER_HMGB2 |
ATG12_CDH1_ID2_HMGB2_RPS19BP1 | ATG12_CDH1_ID2_MMP9_BECN1_HMGB2 |
ATG12_LC3_CDH1_AGER_HMGB2 | CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 |
FAS_CDH1_ID2_AGER_HMGB2 | ATG12_DRAM_FAS_CDH1_ID2_HMGB2 |
ATG12_CDH1_ID2_MMP9_TCF3 | ATG12_CDH1_ID2_MMP9_TCF3_HMGB2 |
七种的组合 | 八种的组合 |
ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 |
ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 | ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3 |
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 | ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 |
ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 |
ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 | ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 | ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 |
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 | ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3 |
ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2 | ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 |
ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2 | ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1 | ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 |
ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 | ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 |
ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 | ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 |
ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 | ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 |
ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 |
ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2 | ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1 |
ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2 | ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 | ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 | ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 |
ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2 | ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 |
ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 | ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1 |
ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2 | ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 |
ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 | ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 |
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 | ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 |
ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 |
ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 |
ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2 | ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1 |
ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 | ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 |
ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2 | ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 |
ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 | ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 |
ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB2 | ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2 |
ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB2 | ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2 |
ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2 | ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 |
ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 | ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 |
ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2 | ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 | ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 |
ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2 | ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 |
ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2 | ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 |
ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 | ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 | ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 | ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1 |
ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 | ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 |
ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1 | ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 |
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 | AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1 |
ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 | ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 |
AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 | ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1 |
ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2 | ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3 |
ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 | ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3 |
AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1 | ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1 |
ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 | ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 |
ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2 | ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 |
ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 | ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 |
AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9 | ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2 |
ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2 | ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3 |
ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 | ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1 |
ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2 | ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 |
ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 | ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2 |
优选的是,所述组合物或试剂盒用于预测A1组的无病存活预后,并且所述基因是选自下表6所示的基因或基因的组中的一种或多种。
[表6]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
MMP2 | ID2_CDH2 | FRAP1_CASP3_CDH2 | FRAP1_TKT_CASP3_CDH2 |
ID2 | FRAP1_TWIST1 | ID2_CDH2_SESN3 | ID2_CDH2_MMP2_SESN3 |
TWIST1 | FRAP1_CASP3 | ID2_CDH2_MMP2 | CBS_ID2_CDH2_SESN3 |
BECN1 | FRAP1_SESN1 | FRAP1_CDH2_TWIST1 | FRAP1_TKT_CDH2_TWIST1 |
BAX | BAX_FRAP1 | FRAP1_CDH2_SESN1 | FRAP1_LC3_CASP3_CDH2 |
BCL2L1 | FRAP1_NNMT | FRAP1_NNMT_CDH2 | FRAP1_NNMT_TKT_CDH2 |
CDH2 | FRAP1_CCNG2 | AIFM1_FRAP1_CDH2 | ID2_CDH2_RPS19BP1_SESN3 |
FASLG | BCL2L1_FRAP1 | FRAP1_TKT_TWIST1 | BAX_FRAP1_TKT_CDH2 |
AGER | FRAP1_RAGE | BAX_FRAP1_CDH2 | BAX_FRAP1_LC3_CDH2 |
ATG12 | AIFM1_FRAP1 | FRAP1_LC3_TWIST1 | ATG12_ID2_CDH2_SESN3 |
TKT | BCL2_FRAP1 | AKT1_ID2_CDH2 | ATG12_ID2_MMP2_SESN3 |
FRAP1_VEGF | ATG12_ID2_MMP2 | FRAP1_LC3_CDH2_KIAA1967 | |
FRAP1_PTEN | FRAP1_CDH2_KIAA1967 | AIFM1_FRAP1_TKT_CDH2 | |
HMGB1_TWIST1 | FRAP1_CCNG2_CDH2 | FRAP1_TKT_CDH2_SESN1 | |
ATG12_ID2 | FRAP1_NNMT_MMP2 | ID2_MMP2_RPS19BP1_SESN3 | |
FRAP1_RAPTOR | FRAP1_CDH2_RAGE | FRAP1_CDH2_SESN1_STAT3 | |
FRAP1_KIAA1967 | BCL2L1_FRAP1_CDH2 | FRAP1_LC3_CDH2_TWIST1 | |
ID2_BECN1 | FRAP1_TKT_CASP3 | FRAP1_LC3_NNMT_CDH2 | |
BECN1_SESN3 | ATG12_MMP2_SESN3 | FRAP1_LC3_CDH2_RAPTOR | |
ATG12_MMP2 | FRAP1_CDH2_VEGF | FRAP1_TKT_CCNG2_CDH2 | |
CDH2_SESN3 | ID2_CDH2_HMGB1 | DIABLO_ID2_CDH2_SESN3 | |
ID2_MMP2 | FRAP1_PTEN_CDH2 | ID2_CDH2_HMGB2_SESN3 |
FRAP1_XIAP | CDH1_ID2_CDH2 | FRAP1_TKT_CDH2_KIAA1967 | |
AKT1_CDH2 | FRAP1_CASP3_MMP2 | FRAP1_LC3_CDH2_RAGE | |
FRAP1_PRKAA1 | FRAP1_LC3_CASP3 | BAX_FRAP1_TKT_MMP2 | |
ID2_RPS19BP1 | BCL2_FRAP1_CDH2 | BCL2L1_FRAP1_TKT_CDH2 | |
TKT_MMP2 | BAX_FRAP1_TKT | FRAP1_CASP3_CDH2_STAT3 | |
BAX_TWIST1 | FRAP1_CDH2_RAPTOR | FRAP1_PTEN_TKT_CDH2 | |
BECN1_FASLG | BAX_FRAP1_LC3 | FRAP1_ID2_CDH2_TWIST1 | |
ATG12_SESN3 | BAX_FRAP1_MMP2 | ID2_CDH2_NAMPT_SESN3 | |
CDH2_MMP2 | FAS_ID2_CDH2 | FRAP1_TKT_CDH2_VEGF | |
BECN1_MMP2 | FRAP1_RPS19BP1_TWIST1 | FRAP1_LC3_CDH2_VEGF | |
BAX_MMP2 | FRAP1_LC3_NNMT | FRAP1_NNMT_CDH2_MMP2 | |
ID2_NAMPT | FRAP1_LC3_RAGE | AIFM1_FRAP1_LC3_CDH2 | |
CASP8_ID2 | FRAP1_HMGB1_TWIST1 | FRAP1_LC3_PTEN_CDH2 | |
ID2_TWIST1 | FRAP1_SESN1_STAT3 | FRAP1_TKT_CDH2_RAGE | |
MMP2_SESN3 | FRAP1_TKT_SESN1 | FRAP1_CDH2_HMGB1_TWIST1 | |
AKT1_BAX | ATG3_ID2_CDH2 | FAS_FRAP1_CDH2_SESN1 | |
FRAP1_TP63 | FRAP1_ID2_CDH2 | FRAP1_CASP3_CDH2_MMP2 | |
BAX_LC3 | FRAP1_TKT_CCNG2 | DRAM_ID2_CDH2_SESN3 | |
ATG12_FASLG | FAS_FRAP1_TWIST1 | LC3_HMGB1_STAT3_TWIST1 | |
LC3_TWIST1 | FRAP1_NNMT_TKT | CASP8_ID2_CDH2_SESN3 | |
AKT1_TWIST1 | AIFM1_FRAP1_MMP2 | FRAP1_TKT_CDH2_RAPTOR | |
ID2_FASLG | ID2_CDH2_CIAP2 | BCL2L1_FRAP1_LC3_CDH2 | |
STAT3_TWIST1 | FRAP1_LC3_VEGF | FRAP1_CDH2_KIAA1967_MMP2 | |
TKT_FASLG | CDH2_MMP2_SESN3 | FRAP1_TKT_CASP3_FASLG | |
AKT1_ATG12 | ID2_CDH2_FASLG | TKT_ID2_CDH2_MMP2 | |
MMP2_NAMPT | CBS_ID2_CDH2 | FRAP1_NNMT_TKT_MMP2 | |
ID2_SIRT1 | FRAP1_LC3_CCNG2 | FRAP1_TKT_CASP3_MMP2 | |
ID2_AGER | BCL2L1_FRAP1_TKT | ID2_CDH2_CIAP2_SESN3 | |
ATG7_TWIST1 | FRAP1_ID2_TWIST1 | FRAP1_CDH2_STAT3_TWIST1 | |
AKT1_BCL2L1 | AIFM1_FRAP1_LC3 | CBS_FRAP1_CASP3_CDH2 | |
BAX_TKT | AIFM1_FRAP1_TKT | BAX_FRAP1_CDH2_MMP2 | |
KIAA1967_MMP2 | ATG5_ID2_CDH2 | ATG12_TKT_MMP2_SESN3 | |
BCL2L1_MMP2 | FRAP1_TKT_RAGE | FRAP1_CDH1_CASP3_CDH2 | |
ATG7_TP63 | BCL2L1_FRAP1_MMP2 | BAX_FRAP1_BECN1_CDH2 | |
LC3_BECN1 | FRAP1_CDH2_TP63 | ID2_CDH2_HMGB1_MMP2 | |
CDH1_ID2_MMP9_TCF3 |
五种的组合 | 六种的组合 |
ID2_CDH2_MMP2_RPS19BP1_SESN3 | AKT1_ATG12_FAS_CDH2_STAT3_TP63 |
ATG12_ID2_CDH2_MMP2_SESN3 | AKT1_FAS_BECN1_CDH2_STAT3_TP63 |
FRAP1_LC3_CASP3_CDH2_STAT3 | AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63 |
ATG12_ID2_MMP2_RPS19BP1_SESN3 | AKT1_FAS_LC3_CDH2_STAT3_TP63 |
AKT1_FAS_CDH2_STAT3_TP63 | ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3 |
FRAP1_TKT_CASP3_CDH2_STAT3 | AKT1_ATG12_BECN1_CDH2_STAT3_TP63 |
CASP8_ID2_CDH2_MMP2_SESN3 | AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63 |
FRAP1_TKT_CASP3_CDH2_FASLG | ATG12_ID2_CDH2_HMGB1_MMP2_SESN3 |
BAX_FRAP1_LC3_TKT_CDH2 | FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 |
ID2_CDH2_HMGB2_MMP2_SESN3 | FRAP1_LC3_TKT_CASP3_CDH2_STAT3 |
DIABLO_ID2_CDH2_MMP2_SESN3 | FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 |
FRAP1_LAMP1_TKT_CASP3_CDH2 | ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3 |
CBS_ID2_CDH2_MMP2_SESN3 | ATG12_ID2_CDH2_CIAP2_MMP2_SESN3 |
FRAP1_LC3_NNMT_CDH2_STAT3 | FAS_FRAP1_LC3_CDH2_SESN1_STAT3 |
FRAP1_TKT_CDH2_SESN1_STAT3 | FRAP1_TKT_BECN1_CASP3_CDH2_STAT3 |
LC3_CDH2_HMGB1_STAT3_TWIST1 | ATG12_FRAP1_ID2_CDH2_MMP2_SESN3 |
DRAM_ID2_CDH2_MMP2_SESN3 | FAS_LC3_CDH2_HMGB1_STAT3_TWIST1 |
FRAP1_LC3_CDH2_SESN1_STAT3 | ATG12_TKT_ID2_CDH2_MMP2_SESN3 |
CBS_FRAP1_TKT_CASP3_CDH2 | ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3 |
ID2_MMP2_NAMPT_RPS19BP1_SESN3 | AKT1_CASP8_FAS_CDH2_STAT3_TP63 |
AKT1_ID2_CDH2_RPS19BP1_SESN3 | AKT1_FAS_CASP3_CDH2_STAT3_TP63 |
ID2_CDH2_MMP2_NAMPT_SESN3 | FAS_FRAP1_LC3_NNMT_CDH2_STAT3 |
AKT1_BECN1_CDH2_STAT3_TP63 | FAS_FRAP1_TKT_CDH2_SESN1_STAT3 |
FAS_FRAP1_LC3_CDH2_RAPTOR | ATG12_ID2_CDH2_MMP2_SESN3_STAT3 |
FRAP1_LC3_CDH2_STAT3_TWIST1 | FRAP1_NNMT_TKT_BECN1_CDH2_STAT3 |
BAX_FRAP1_TKT_CDH2_MMP2 | ATG12_FAS_FRAP1_CDH2_STAT3_TP63 |
FAS_FRAP1_LC3_CDH2_KIAA1967 | ATG12_ATG3_ID2_CDH2_MMP2_SESN3 |
AKT1_ATG7_CDH2_RPS19BP1_TP63 | DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
FAS_FRAP1_LC3_CDH2_RAGE | ATG12_CBS_ID2_CDH2_MMP2_SESN3 |
FAS_LC3_HMGB1_STAT3_TWIST1 | ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3 |
FRAP1_LC3_TKT_CASP3_CDH2 | FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
FRAP1_TKT_CASP3_CDH2_CIAP2 | AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
TKT_ID2_CDH2_MMP2_SESN3 | FAS_FRAP1_LC3_CASP3_CDH2_STAT3 |
FRAP1_TKT_CDH2_KIAA1967_MMP2 | ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
FRAP1_TKT_CDH2_HMGB1_TWIST1 | AKT1_FAS_CDH2_HMGB1_STAT3_TP63 |
BAX_FRAP1_LC3_BECN1_CDH2 | CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
FRAP1_TKT_CDH2_STAT3_TWIST1 | ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
AKT1_ATG12_ID2_CDH2_SESN3 | FRAP1_LC3_NNMT_TKT_CDH2_STAT3 |
BAX_FAS_FRAP1_LC3_CDH2 | CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
ATG12_CBS_ID2_MMP2_SESN3 | AKT1_ATG12_CDH2_HMGB1_STAT3_TP63 |
FAS_FRAP1_CDH2_SESN1_STAT3 | FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 |
FRAP1_BECN1_CASP3_CDH2_STAT3 | AKT1_ATG12_ID2_CDH2_MMP2_SESN3 |
FAS_FRAP1_TKT_CDH2_SESN1 | ATG12_ATG5_ID2_CDH2_MMP2_SESN3 |
FRAP1_LC3_CCNG2_CDH2_STAT3 | AKT1_ATG12_FAS_BECN1_STAT3_TP63 |
ID2_CDH2_MMP2_SESN3_UVRAG | AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63 |
ATG7_ID2_CDH2_MMP2_SESN3 | FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR |
ID2_CDH2_HMGB1_RPS19BP1_SESN3 | FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
FRAP1_TKT_CDH2_MMP2_RAPTOR | ATG12_CDH1_ID2_CDH2_MMP2_SESN3 |
FRAP1_LC3_BECN1_CDH2_RAPTOR | FRAP1_LC3_TKT_CDH2_STAT3_TWIST1 |
ATG12_ID2_CDH2_FASLG_SESN3 | CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
ATG7_FRAP1_TKT_CASP3_CDH2 | FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1 |
FRAP1_TKT_CASP3_CDH2_MMP2 | FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1 |
FRAP1_LC3_CDH2_HMGB1_TWIST1 | ATG12_ID2_CDH2_HMGB2_MMP2_SESN3 |
FRAP1_LC3_TKT_CDH2_KIAA1967 | ATG12_FAS_ID2_CDH2_MMP2_SESN3 |
ATG7_ID2_CDH2_RPS19BP1_TP63 | TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
BAX_FRAP1_TKT_BECN1_CDH2 | BAX_FAS_FRAP1_LC3_TKT_CDH2 |
ATG3_FRAP1_TKT_CASP3_CDH2 | ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3 |
CDH1_ID2_MMP9_TCF3_CDH2 | CDH1_ID2_MMP9_TCF3_CDH2_SESN3 |
七种的组合 | 八种的组合 |
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 |
AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 |
AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 | AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 | AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 | AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 | AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 |
AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 | AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 | AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 | AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 | AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 | AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63 |
AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63 |
AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 | AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63 |
AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 | AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 |
ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63 |
AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 | AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63 |
AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63 |
AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63 |
AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63 |
AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 | AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 | AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63 |
FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 | AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63 |
AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 | AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 |
FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR | AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 | AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 | AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 | AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63 |
AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 | AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 | AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 |
FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 | AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63 |
FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 | AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STAT3_TP63 |
ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 | AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_NNMT_CDH2_STAT3_TP63 |
FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 | AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63 |
FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 | AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63 |
FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 | AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63 |
AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63 |
AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 | AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 |
AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 | AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 | AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 | AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63 |
AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 | AKT1_ATG12_CASP8_FAS_CDH2_CIAP2_STAT3_TP63 |
CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 | AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 |
优选的是,所述组合物或试剂盒用于预测A2组的复发预后,并且所述基因是选自下表7所示的基因或基因的组中的一种或多种。
[表7]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
TKT | PRKAA1_LAMP2 | LC3_SESN2_SIRT1 | ATG5_LC3_SESN2_SIRT1 |
SESN2 | TKT_SESN2 | BNIP3_PRKAA1_LAMP2 | ATG3_LC3_SESN2_SIRT1 |
LAMP2 | ATG7_LAMP2 | ATG5_LC3_SESN2 | CSE1L_LC3_SESN2_SIRT1 |
LAMP2_SESN2 | BNIP3_LC3_SESN2 | ATG5_CSE1L_LC3_SESN2 | |
AKT1_PRKAA1 | ATG7_LC3_SESN2 | BNIP3_LC3_SESN2_SIRT1 | |
SESN2_SIRT1 | AKT1_PRKAA1_LAMP2 | FRAP1_LC3_SESN2_SIRT1 | |
TKT_VEGF | ATG7_TKT_SESN2 | AKT1_ATG3_PRKAA1_LAMP2 | |
ATG7_TKT | DRAM_LC3_SESN2 | ATG3_ATG5_LC3_SESN2 | |
TKT_LAMP2 | PRKAA1_AGER_LAMP2 | ATG7_LC3_SESN2_SIRT1 | |
BHLHE41_SESN2 | PRKAA1_TKT_LAMP2 | BNIP3_CSE1L_LC3_SESN2 | |
TKT_BHLHE41 | ATG7_TKT_LAMP2 | TKT_LAMP2_SESN2_SIRT1 | |
ATG5_SESN2 | TKT_LAMP2_SESN2 | CIAP2_LAMP2_SESN2_SIRT1 | |
LAMP1_SESN2 | TKT_LAMP2_VEGF | ATG12_TKT_LAMP2_SESN2 | |
CSE1L_LAMP2 | ATG12_LC3_SESN2 | ATG7_TKT_LAMP2_SESN2 | |
ATG12_SESN2 | ATG7_LAMP2_SESN2 | AKT1_ATG7_PRKAA1_LAMP2 | |
AKT1_TKT | TKT_SESN2_SIRT1 | ATG5_BNIP3_LC3_SESN2 | |
E2F1_SESN2 | E2F1_LC3_SESN2 | ATG3_BNIP3_LC3_SESN2 | |
ATG3_LAMP2 | LC3_SESN2_UVRAG | AKT1_PRKAA1_LAMP2_UVRAG | |
BNIP3_SESN2 | PRKAA1_CCNG2_LAMP2 | DRAM_LC3_SESN2_SIRT1 |
LC3_SESN2 | AKT1_ATG7_TKT | ATG7_CSE1L_LC3_SESN2 | |
TWIST1_VEGF | ATG5_PRKAA1_LAMP2 | ATG7_FRAP1_LC3_SESN2 | |
ATG7_LC3 | ATG3_LAMP2_SESN2 | BNIP3_PRKAA1_LAMP2_SESN2 | |
CSE1L_SESN2 | BNIP3_TKT_SESN2 | ATG5_ATG7_LC3_SESN2 | |
ATG5_LC3 | LAMP2_SESN2_SIRT1 | PRKAA1_TKT_LAMP2_SESN2 | |
ATG7_SESN2 | ATG7_PRKAA1_LAMP2 | ATG3_ATG7_LC3_SESN2 | |
LC3_ULK1 | LAMP1_LC3_SESN2 | BNIP3_PRKAA1_AGER_LAMP2 | |
ATG3_TKT | ATG12_PRKAA1_LAMP2 | E2F1_LC3_SESN2_SIRT1 | |
DRAM_SESN2 | CASP8_PRKAA1_LAMP2 | LC3_ID2_SESN2_SIRT1 | |
PRKAA1_TKT | AIFM1_TKT_SESN2 | LC3_NAMPT_SESN2_SIRT1 | |
BHLHE41_LAMP2 | FRAP1_SESN2_SIRT1 | ATG5_FRAP1_LC3_SESN2 | |
LAMP2_VEGF | PRKAA1_HMGB1_LAMP2 | ATG7_BNIP3_LC3_SESN2 | |
AKT1_VEGF | LC3_BHLHE41_SESN2 | LC3_RPS19BP1_SESN2_SIRT1 | |
TKT_CIAP2 | ATG12_TKT_SESN2 | AKT1_ATG7_TKT_SESN2 | |
CSE1L_BHLHE41 | CSE1L_LAMP2_SESN2 | BCL2L1_BNIP3_PRKAA1_LAMP2 | |
LC3_BHLHE41 | PRKAA1_CASP3_LAMP2 | CSE1L_DRAM_LC3_SESN2 | |
LC3_SIRT1 | PRKAA1_LAMP2_RAGE | DIABLO_LC3_SESN2_SIRT1 | |
CSE1L_LAMP1 | PRKAA1_LAMP2_SESN2 | LC3_SESN2_SIRT1_STAT3 | |
TKT_RPS19BP1 | TKT_CIAP2_SESN2 | ATG12_ATG5_LC3_SESN2 | |
CBS_TKT | BCL2L1_PRKAA1_LAMP2 | BNIP3_PRKAA1_TCF3_LAMP2 | |
CSE1L_BECN1 | DIABLO_PRKAA1_LAMP2 | LC3_SESN2_SIRT1_UVRAG | |
TKT_CDH1 | PRKAA1_CDH1_LAMP2 | BNIP3_PRKAA1_MMP9_LAMP2 | |
TKT_HMGB1 | CBS_PRKAA1_LAMP2 | AKT1_LC3_SESN2_SIRT1 | |
TKT_RAGE | CSE1L_SESN2_SIRT1 | AKT1_PRKAA1_CDH1_LAMP2 | |
AIFM1_SESN2 | ATG3_PRKAA1_LAMP2 | CSE1L_LAMP1_LC3_SESN2 | |
ATG7_TWIST1 | PRKAA1_FASLG_LAMP2 | ATG7_PRKAA1_TKT_LAMP2 | |
BHLHE41_NAMPT | PRKAA1_ID2_LAMP2 | KIAA1967_LAMP2_SESN2_SIRT1 | |
BNIP3_LC3 | PRKAA1_LAMP2_SATB1 | LC3_SESN2_SESN3_SIRT1 | |
PRKAA1_SESN2 | PRKAA1_LAMP2_SESN1 | BNIP3_PRKAA1_HMGB1_LAMP2 | |
ATG7_NAMPT | AKT1_ATG7_PTEN | CSE1L_LC3_SESN2_UVRAG | |
BECN1_SESN2 | ATG7_TKT_BHLHE41 | LC3_MMP9_SESN2_SIRT1 | |
TKT_HMGB2 | PRKAA1_LAMP2_MMP2 | ATG3_LAMP2_SESN2_SIRT1 | |
TKT_SIRT1 | CSE1L_LAMP1_SESN2 | BNIP3_PRKAA1_CCNG2_LAMP2 | |
ATG5_CSE1L | PRKAA1_LAMP2_SESN3 | BNIP3_PRKAA1_LAMP2_SATB1 | |
SESN2_UVRAG | ATG3_TKT_SESN2 | BNIP3_PRKAA1_LAMP2_SESN1 | |
TKT_CASP3 | ATG5_CSE1L_SESN2 | ATG5_DRAM_LC3_SESN2 | |
TKT_CDH2 | ATG5_CSE1L_LC3 | BNIP3_PRKAA1_CASP3_LAMP2 | |
TKT_MMP2 | FRAP1_PRKAA1_LAMP2 | BNIP3_FRAP1_LC3_SESN2 | |
五种的组合 | 六种的组合 |
CIAP2_FASLG_LAMP2_SESN2_SIRT1 | LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG5_LC3_SESN2_SIRT1 | CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_FRAP1_LC3_SESN2_SIRT1 | NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG7_FRAP1_LC3_SESN2_SIRT1 | CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
TKT_CIAP2_LAMP2_SESN2_SIRT1 | AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG5_FRAP1_LC3_SESN2_SIRT1 | CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 |
ATG5_BNIP3_LC3_SESN2_SIRT1 | CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 |
TKT_CDH1_LAMP2_SESN2_SIRT1 | CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
CSE1L_FRAP1_LC3_SESN2_SIRT1 | AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_BNIP3_LC3_SESN2_SIRT1 | ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG5_CSE1L_LC3_SESN2_SIRT1 | FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_LC3_LAMP2_SESN2_SIRT1 | CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 |
BNIP3_FRAP1_LC3_SESN2_SIRT1 | TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
BNIP3_PRKAA1_TKT_LAMP2_SESN2 | ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 |
ATG12_TKT_LAMP2_SESN2_SIRT1 | ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG5_ATG7_LC3_SESN2_SIRT1 | BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG7_BNIP3_TKT_LAMP2_SESN2 | CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1 |
AKT1_ATG7_BNIP3_PRKAA1_LAMP2 | ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG7_LC3_SESN2_SIRT1 | CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG5_BNIP3_LC3_SESN2 | FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
BNIP3_CSE1L_LC3_SESN2_SIRT1 | MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG5_DRAM_LC3_SESN2_SIRT1 | CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 |
AIFM1_CIAP2_LAMP2_SESN2_SIRT1 | ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 |
ATG7_TKT_LAMP2_SESN2_SIRT1 | CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_LC3_SESN2 | LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG7_LC3_NAMPT_SESN2_SIRT1 | TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG5_E2F1_LC3_SESN2_SIRT1 | ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 |
BNIP3_CSE1L_FRAP1_LC3_SESN2 | ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1 |
ATG7_LC3_LAMP2_SESN2_SIRT1 | ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1 |
AIFM1_BNIP3_PRKAA1_LAMP2_SESN2 | ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 |
ATG12_BNIP3_TKT_LAMP2_SESN2 | ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1 |
CIAP2_KIAA1967_LAMP2_SESN2_SIRT1 | E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG12_ATG5_BNIP3_LC3_SESN2 | ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1 |
ATG3_ATG7_LC3_LAMP2_SESN2 | ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 |
ATG12_TKT_CIAP2_LAMP2_SESN2 | ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 |
ATG5_BNIP3_CSE1L_LC3_SESN2 | TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1 |
AKT1_ATG7_PRKAA1_TKT_LAMP2 | ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1 |
ATG3_LC3_NAMPT_SESN2_SIRT1 | ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1 |
ATG3_CSE1L_LC3_SESN2_SIRT1 | AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG7_FRAP1_LC3_SESN2 | ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG5_LC3_ID2_SESN2_SIRT1 | CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1 |
BNIP3_E2F1_LC3_SESN2_SIRT1 | ATG3_ATG5_LC3_ID2_SESN2_SIRT1 |
ATG3_LC3_ID2_SESN2_SIRT1 | AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1 |
ATG7_CSE1L_FRAP1_LC3_SESN2 | ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1 |
AIFM1_TKT_LAMP2_SESN2_SIRT1 | ATG3_ATG5_E2F1_LC3_SESN2_SIRT1 |
LC3_CIAP2_LAMP2_SESN2_SIRT1 | ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1 |
ATG12_TKT_CDH1_LAMP2_SESN2 | ATG3_ATG5_LC3_SESN2_SIRT1_STAT3 |
ATG5_LC3_SESN2_SIRT1_STAT3 | AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG |
ATG3_DRAM_LC3_SESN2_SIRT1 | AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1 |
ATG5_DIABLO_LC3_SESN2_SIRT1 | ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1 |
ATG7_BNIP3_LC3_SESN2_SIRT1 | ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1 |
CDH2_CIAP2_LAMP2_SESN2_SIRT1 | TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1 |
ATG3_ATG5_FRAP1_LC3_SESN2 | ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1 |
DRAM_TKT_LAMP2_SESN2_SIRT1 | ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 |
ATG12_ATG3_TKT_LAMP2_SESN2 | BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG3_LC3_SESN2_SIRT1_STAT3 | AKT1_ATG3_ATG5_LC3_SESN2_SIRT1 |
ATG5_LC3_SESN2_SIRT1_UVRAG | AIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2 |
TKT_CDH1_ID2_MMP9_TCF3_SESN2 |
七种的组合 | 八种的组合 |
ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 | ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1 |
MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 | MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 | FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 | ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 | FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 |
LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1 |
LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 | FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 | ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3 |
CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 | NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 | FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 | CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1 |
ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 |
LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 | TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 | CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1 |
AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 | ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 |
NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 | AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 | LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 |
NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 | MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 | FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 | FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1 |
BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3 |
ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 | CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN1_SESN2_SIRT1 |
LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 |
LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1 |
AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1 |
FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1 |
CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 | FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 |
CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 | CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 |
ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1 |
ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 | LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1 |
LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 | AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 |
TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 | ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1 |
FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 | MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 | FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 | LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 |
NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 |
ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 | LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 | ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 |
BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 | TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1 |
优选的是,所述组合物或试剂盒用于预测A2组的存活预后,并且所述基因是选自下表8所示的基因或基因的组中的一种或多种。
[表8]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
BCL2L1 | BCL2L1_NNMT | BCL2L1_NNMT_PRKAA1 | ATG3_BCL2L1_NNMT_PRKAA1 |
FAS | BCL2L1_E2F1 | BCL2L1_E2F1_PRKAA1 | BCL2L1_TKT_CASP3_SESN2 |
LAMP1 | BCL2L1_TKT | ATG3_BCL2L1_PRKAA1 | BCL2L1_ID2_CASP3_SESN2 |
BHLHE41 | FAS_LAMP1 | ATG3_BCL2L1_NNMT | ATG3_BCL2L1_E2F1_PRKAA1 |
TKT | BCL2L1_PRKAA1 | ATG3_BCL2L1_E2F1 | BCL2L1_NNMT_PRKAA1_HMGB1 |
LC3 | FAS_BHLHE41 | FAS_BHLHE41_SESN2 | BCL2L1_NNMT_PRKAA1_MMP2 |
SESN2 | FAS_TKT | BCL2L1_PRKAA1_HMGB2 | BCL2L1_NNMT_PRKAA1_CDH1 |
BCL2L1_CASP3 | BCL2L1_CASP3_SESN2 | FAS_TKT_CASP3_SESN2 | |
ATG3_BCL2L1 | BCL2L1_PRKAA1_TKT | BCL2L1_NNMT_PRKAA1_VEGF | |
ATG7_BCL2L1 | FAS_CASP3_SESN2 | ATG7_BCL2L1_NNMT_PRKAA1 | |
FAS_CASP3 | BCL2L1_TKT_CASP3 | BCL2L1_FRAP1_NNMT_PRKAA1 | |
TKT_BHLHE41 | FAS_TKT_CASP3 | BCL2L1_NNMT_PRKAA1_ID2 | |
BCL2L1_KIAA1967 | BCL2L1_E2F1_TKT | AIFM1_BCL2L1_NNMT_PRKAA1 | |
FAS_PRKAA1 | BCL2L1_NNMT_TKT | BCL2L1_TKT_BHLHE41_CASP3 | |
FAS_KIAA1967 | FAS_TKT_BHLHE41 | BCL2L1_NNMT_PRKAA1_CDH2 | |
FAS_SESN2 | FAS_TKT_SESN2 | BCL2L1_CSE1L_NNMT_PRKAA1 |
BCL2L1_HMGB2 | FAS_LAMP1_BHLHE41 | BCL2L1_NNMT_PRKAA1_HMGB2 | |
BCL2L1_VEGF | FAS_LAMP1_SESN2 | BCL2L1_CBS_NNMT_PRKAA1 | |
BNIP3_FAS | ATG3_BCL2L1_TKT | FAS_TKT_SESN2_TP63 | |
FAS_TWIST1 | ATG7_BCL2L1_PRKAA1 | BCL2L1_DRAM_NNMT_PRKAA1 | |
BNIP3_TKT | DIABLO_FAS_BHLHE41 | BCL2L1_NNMT_PRKAA1_ULK1 | |
BCL2L1_CSE1L | TKT_SESN2_TP63 | BNIP3_TKT_CASP3_SESN2 | |
TKT_SESN2 | FAS_PRKAA1_TKT | ATG5_BCL2L1_NNMT_PRKAA1 | |
BCL2L1_FRAP1 | ATG7_BCL2L1_NNMT | BCL2L1_DIABLO_NNMT_PRKAA1 | |
LAMP1_SESN2 | BCL2L1_BNIP3_TKT | BCL2L1_NNMT_CASP3_SESN2 | |
LC3_BHLHE41 | BNIP3_FAS_TKT | FAS_TKT_BHLHE41_CASP3 | |
BCL2L1_BNIP3 | BCL2L1_NNMT_CASP3 | BCL2L1_NNMT_PRKAA1_TKT | |
BCL2L1_LC3 | TKT_BHLHE41_CASP3 | BNIP3_FAS_TKT_CASP3 | |
ATG5_BCL2L1 | ATG3_BCL2L1_CASP3 | ATG3_ATG7_BCL2L1_PRKAA1 | |
BCL2L1_CBS | BCL2L1_PRKAA1_CASP3 | FAS_ID2_CASP3_SESN2 | |
CSE1L_LAMP1 | BCL2L1_PRKAA1_MMP2 | BCL2L1_NNMT_PRKAA1_CASP3 | |
E2F1_FAS | FAS_BHLHE41_CASP3 | ATG3_BCL2L1_PRKAA1_HMGB2 | |
AIFM1_BCL2L1 | FAS_TKT_KIAA1967 | FAS_LC3_BHLHE41_SESN2 | |
BHLHE41_SESN2 | FAS_TKT_TWIST1 | ATG3_BCL2L1_BNIP3_NNMT | |
CASP8_FAS | BCL2L1_E2F1_NNMT | BCL2L1_CASP8_NNMT_PRKAA1 | |
FAS_NAMPT | BCL2L1_FRAP1_NNMT | FAS_BHLHE41_CASP3_SESN2 | |
FAS_TP63 | BCL2L1_TKT_BHLHE41 | BCL2L1_BNIP3_NNMT_TKT | |
LAMP1_BHLHE41 | BCL2L1_TKT_SESN2 | DIABLO_FAS_BHLHE41_SESN2 | |
ATG12_FAS | FAS_KIAA1967_SESN2 | ATG3_BCL2L1_PRKAA1_TKT | |
BCL2L1_MMP2 | DIABLO_FAS_LAMP1 | BCL2L1_NNMT_PRKAA1_MMP9 | |
BHLHE41_CASP3 | ATG3_BCL2L1_KIAA1967 | BNIP3_FAS_CASP3_SESN2 | |
FAS_HMGB1 | ATG7_BCL2L1_E2F1 | FAS_LAMP1_BHLHE41_SESN2 | |
FAS_VEGF | FAS_BHLHE41_SATB1 | BCL2L1_CASP3_SESN1_SESN2 | |
LAMP1_TCF3 | ATG3_ATG7_BCL2L1 | BCL2L1_NNMT_PRKAA1_SIRT1 | |
BCL2L1_ULK1 | ATG7_BCL2L1_TKT | DIABLO_FAS_LAMP1_BHLHE41 | |
FAS_LC3 | BCL2L1_BNIP3_NNMT | FAS_TKT_CASP3_SIRT1 | |
NNMT_BHLHE41 | BCL2L1_PRKAA1_VEGF | E2F1_FAS_BHLHE41_SESN2 | |
BCL2L1_FAS | BCL2L1_BHLHE41_CASP3 | FAS_TKT_CASP3_FASLG | |
TKT_TP63 | FAS_SESN2_TP63 | FAS_TKT_HMGB1_SESN2 | |
AKT1_BCL2L1 | TKT_BHLHE41_TP63 | FAS_CASP3_HMGB1_SESN2 | |
ATG12_BCL2L1 | AIFM1_BCL2L1_NNMT | BAX_BCL2L1_NNMT_PRKAA1 | |
FAS_HMGB2 | BCL2L1_CSE1L_NNMT | BCL2L1_E2F1_NNMT_PRKAA1 | |
BCL2L1_ID2 | BCL2L1_E2F1_FRAP1 | ATG3_BCL2L1_PRKAA1_MMP2 | |
BCL2L1_RPS19BP1 | BNIP3_FAS_CASP3 | FAS_TKT_KIAA1967_SESN2 | |
TKT_SATB1 | FAS_TKT_SATB1 | BNIP3_FAS_TKT_TWIST1 | |
FAS_XIAP | BCL2L1_CSE1L_PRKAA1 | ATG3_BCL2L1_BNIP3_TKT | |
BCL2_BCL2L1 | BCL2L1_NNMT_VEGF | BCL2L1_NNMT_PRKAA1_PTEN | |
五种的组合 | 六种的组合 |
BCL2L1_NNMT_ID2_CASP3_SESN2 | BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 |
BCL2L1_PTEN_TKT_CASP3_SESN2 | BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_HMGB1 | ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 |
BCL2L1_TKT_XIAP_CASP3_SESN2 | BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2 |
BCL2L1_TKT_CASP3_HMGB1_SESN2 | BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_ID2 | BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 |
BCL2L1_BNIP3_TKT_CASP3_SESN2 | FAS_TKT_CASP3_HMGB1_SESN2_TP63 |
ATG3_BCL2L1_NNMT_PRKAA1_CDH1 | ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1 |
BCL2L1_TKT_CASP3_RAGE_SESN2 | ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_ULK1 | ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF |
FAS_TKT_CASP3_HMGB1_SESN2 | BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2 |
FAS_TKT_CASP3_SESN2_TP63 | BCL2L1_NNMT_ID2_AGER_CASP3_SESN2 |
ATG3_BCL2L1_FRAP1_NNMT_PRKAA1 | BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2 |
FAS_TKT_HMGB1_SESN2_TP63 | BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2 |
AIFM1_ATG3_BCL2L1_NNMT_PRKAA1 | BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2 |
BCL2L1_ID2_CASP3_SESN1_SESN2 | ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_MMP2 | BNIP3_TKT_XIAP_CASP3_RAGE_SESN2 |
BCL2L1_TKT_CASP3_SESN1_SESN2 | BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_VEGF | AIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2 |
BCL2L1_TKT_ID2_CASP3_SESN2 | BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2 |
ATG3_BCL2L1_ID2_CASP3_SESN2 | BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2 |
BNIP3_TKT_XIAP_CASP3_SESN2 | BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2 |
BCL2L1_NNMT_PRKAA1_ID2_SESN2 | ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG |
BCL2L1_NNMT_PRKAA1_HMGB1_VEGF | BCL2L1_NNMT_ID2_CASP3_SESN2_SESN3 |
ATG3_BCL2L1_NNMT_PRKAA1_CDH2 | BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2 |
ATG3_BCL2L1_LAMP1_NNMT_PRKAA1 | BAX_BCL2L1_NNMT_ID2_CASP3_SESN2 |
BCL2L1_NNMT_ID2_SESN2_UVRAG | BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2 |
ATG3_ATG7_BCL2L1_NNMT_PRKAA1 | BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2 |
ATG3_BCL2L1_CBS_NNMT_PRKAA1 | BNIP3_PTEN_TKT_XIAP_CASP3_SESN2 |
BCL2L1_ID2_CASP3_RPS19BP1_SESN2 | BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2 |
BNIP3_FAS_TKT_CASP3_SESN2 | BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2 |
ATG3_BCL2L1_DRAM_NNMT_PRKAA1 | ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 |
ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 | BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2 |
BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2 | ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2 |
BCL2L1_FAS_TKT_CASP3_SESN2 | BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2 |
ATG3_BCL2L1_CSE1L_NNMT_PRKAA1 | ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF |
ATG3_BCL2L1_DIABLO_NNMT_PRKAA1 | BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_SIRT1 | BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2 |
BCL2L1_CASP8_ID2_CASP3_SESN2 | BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2 |
BCL2L1_DIABLO_ID2_CASP3_SESN2 | BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2 |
BCL2L1_TKT_CASP3_SESN2_STAT3 | BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2 |
BCL2L1_NNMT_PRKAA1_ID2_VEGF | BCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2 |
BCL2L1_ID2_CASP3_HMGB2_SESN2 | BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 |
BCL2L1_TKT_CASP3_SESN2_SESN3 | BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2 |
BCL2L1_TKT_CASP3_CCNG2_SESN2 | BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2 |
FAS_TKT_CASP3_FASLG_SESN2 | BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2 |
FAS_TKT_CASP3_SESN2_SIRT1 | BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2 |
BCL2L1_NNMT_ID2_KIAA1967_SESN2 | BNIP3_FAS_TKT_CASP3_HMGB1_SESN2 |
ATG5_BCL2L1_ID2_CASP3_SESN2 | FAS_TKT_XIAP_CASP3_HMGB1_SESN2 |
BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 | BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG |
BCL2L1_TKT_XIAP_BHLHE41_CASP3 | FAS_TKT_HMGB1_KIAA1967_SESN2_TP63 |
FAS_TKT_XIAP_CASP3_SESN2 | BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2 |
BCL2L1_CDH1_ID2_CASP3_SESN2 | BCL2L1_PTEN_TKT_ID2_CASP3_SESN2 |
BCL2L1_TKT_CASP3_SESN2_SIRT1 | BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2 |
ATG7_BCL2L1_NNMT_PRKAA1_ID2 | BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2 |
BCL2_BCL2L1_TKT_CASP3_SESN2 | ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2 |
BCL2L1_ID2_CASP3_CDH2_SESN2 | BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2 |
七种的组合 | 八种的组合 |
BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 | BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2 |
BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 | BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3 |
BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 |
BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 |
ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3 |
BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 | ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 |
BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 | BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 |
BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 |
BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 | BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2 |
BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2 |
BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2 |
BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3 |
BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 | BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2 |
BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 | BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2 |
ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 | BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2 |
BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 | ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 |
BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 | BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 |
ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG | BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2 |
ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 | ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 |
BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 | ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 |
BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2 |
BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 | BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2 |
BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 | BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3 |
ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2 |
BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2 |
BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 | BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 |
BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 | ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 |
BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 | BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 |
BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2 |
BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2 | BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2 |
BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2 |
BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2 | BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2 |
BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 | ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 |
BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2 |
BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 | BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2 |
BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 | AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 |
BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 | ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 |
AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 | BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 |
BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2 |
BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2 |
BCL2L1_NNMT_ID2_AGER_CASP3_RAGE_SESN2 | AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 |
BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 | BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 |
BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 | BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 |
BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2 |
BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 | BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2 |
ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 | BCL2L1_CASP8_NNMT_ID2CASP3_HMGB1_RAGE_SESN2 |
BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 | BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 |
BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 | ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967 |
BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 | BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3 |
BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 | BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 |
BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 | BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3 |
BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 | BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 |
BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 | BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 |
ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 | BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2 |
BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 | BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2 |
BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 | BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 |
优选的是,所述组合物或试剂盒用于预测A2组的无病存活预后,并且所述基因是选自下表9所示的基因或基因的组中的一种或多种。
[表9]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
SESN2 | TKT_SESN2 | ATG7_TKT_SESN2 | ATG5_CSE1L_FRAP1_SESN2 |
TKT | BHLHE41_SESN2 | FRAP1_SESN2_SIRT1 | CSE1L_FRAP1_SESN2_SIRT1 |
LAMP2 | LAMP2_SESN2 | ATG5_LC3_SESN2 | ATG7_TKT_LAMP2_SESN2 |
BHLHE41 | ATG5_SESN2 | ATG5_FRAP1_SESN2 | ATG5_FRAP1_SESN2_SIRT1 |
CSE1L | LAMP1_SESN2 | TKT_LAMP2_SESN2 | AKT1_ATG7_TKT_SESN2 |
SESN2_SIRT1 | AIFM1_TKT_SESN2 | ATG5_CSE1L_LC3_SESN2 | |
E2F1_SESN2 | ATG5_CSE1L_SESN2 | FRAP1_LC3_SESN2_SIRT1 | |
ATG12_SESN2 | LC3_SESN2_SIRT1 | CSE1L_FRAP1_LAMP1_SESN2 | |
TKT_VEGF | ATG12_TKT_SESN2 | ATG7_TKT_SESN2_SESN3 | |
CSE1L_BECN1 | CSE1L_LAMP1_SESN2 | ATG5_FRAP1_LC3_SESN2 | |
CSE1L_SESN2 | TKT_HMGB2_SESN2 | ATG7_CSE1L_FRAP1_SESN2 | |
ATG7_TKT | ATG5_TKT_SESN2 | CSE1L_LC3_SESN2_SIRT1 | |
FASLG_SESN2 | TKT_CDH1_SESN2 | ATG5_LC3_SESN2_SIRT1 | |
PRKAA1_LAMP2 | TKT_SESN2_SESN3 | ATG7_TKT_FASLG_SESN2 |
PRKAA1_SESN2 | TKT_SESN2_VEGF | ATG7_TKT_AGER_SESN2 | |
TKT_BHLHE41 | CSE1L_BHLHE41_SESN2 | ATG7_TKT_HMGB1_SESN2 | |
CSE1L_BHLHE41 | PRKAA1_TKT_SESN2 | ATG7_TKT_MMP2_SESN2 | |
ATG7_SESN2 | ATG3_TKT_SESN2 | BNIP3_CSE1L_FRAP1_SESN2 | |
CSE1L_LAMP2 | TKT_RPS19BP1_SESN2 | ATG5_ATG7_TKT_SESN2 | |
FAS_SESN2 | CBS_TKT_SESN2 | ATG7_BCL2_TKT_SESN2 | |
HMGB2_SESN2 | CSE1L_LAMP2_SESN2 | ATG7_BNIP3_TKT_SESN2 | |
CSE1L_LAMP1 | TKT_SESN2_SIRT1 | FAS_FRAP1_SESN2_SIRT1 | |
BECN1_SESN2 | AKT1_TKT_SESN2 | AIFM1_ATG7_TKT_SESN2 | |
NNMT_SESN2 | CSE1L_SESN2_SIRT1 | ATG12_TKT_LAMP2_SESN2 | |
AIFM1_SESN2 | TKT_CDH2_SESN2 | ATG7_TKT_BHLHE41_SESN2 | |
BAX_SESN2 | BNIP3_TKT_SESN2 | ATG7_TKT_ID2_SESN2 | |
DRAM_SESN2 | NNMT_TKT_SESN2 | CSE1L_DRAM_FRAP1_SESN2 | |
CSE1L_ULK1 | TKT_AGER_SESN2 | CSE1L_FRAP1_SESN2_UVRAG | |
KIAA1967_SESN2 | TKT_BHLHE41_SESN2 | ATG7_LAMP1_TKT_SESN2 | |
SESN2_VEGF | TKT_HMGB1_SESN2 | ATG7_BCL2L1_TKT_SESN2 | |
BNIP3_SESN2 | TKT_MMP2_SESN2 | ATG7_TKT_CCNG2_SESN2 | |
SESN2_UVRAG | E2F1_TKT_SESN2 | CSE1L_E2F1_FRAP1_SESN2 | |
TWIST1_VEGF | NAMPT_SESN2_SIRT1 | CSE1L_LAMP1_LC3_SESN2 | |
PRKAA1_FASLG | TKT_KIAA1967_SESN2 | PRKAA1_TKT_LAMP2_SESN2 | |
TKT_RPS19BP1 | DRAM_TKT_SESN2 | ATG7_CBS_TKT_SESN2 | |
PRKAA1_TKT | TKT_CIAP2_SESN2 | ATG7_LC3_TKT_SESN2 | |
ATG7_LAMP2 | TKT_MMP9_SESN2 | ATG7_NNMT_TKT_SESN2 | |
AGER_SESN2 | ATG5_NAMPT_SESN2 | ATG7_TKT_CIAP2_SESN2 | |
CDH2_SESN2 | ATG7_FRAP1_SESN2 | ATG7_TKT_SESN2_STAT3 | |
AKT1_PRKAA1 | CSE1L_E2F1_SESN2 | ATG7_PTEN_TKT_SESN2 | |
ULK1_SESN2 | LAMP1_TKT_SESN2 | ATG7_TKT_CASP3_SESN2 | |
MMP2_SESN2 | LC3_TKT_SESN2 | ATG7_TKT_CDH2_SESN2 | |
ATG5_CSE1L | TKT_CASP3_SESN2 | ATG7_TKT_HMGB2_SESN2 | |
HMGB1_SESN2 | TKT_CCNG2_SESN2 | ATG7_TKT_NAMPT_SESN2 | |
AKT1_TKT | TKT_ID2_SESN2 | ATG7_TKT_RAPTOR_SESN2 | |
CBS_SESN2 | TKT_RAPTOR_SESN2 | ATG7_TKT_SESN2_SIRT1 | |
FRAP1_SESN2 | TKT_XIAP_SESN2 | ATG7_FRAP1_LC3_SESN2 | |
CIAP2_SESN2 | BAX_TKT_SESN2 | ATG7_TKT_BECN1_SESN2 | |
BCL2_SESN2 | BCL2_TKT_SESN2 | ATG7_DIABLO_TKT_SESN2 | |
CCNG2_SESN2 | ATG12_CSE1L_SESN2 | ATG7_FRAP1_SESN2_SIRT1 | |
BCL2L1_SESN2 | BCL2L1_TKT_SESN2 | ATG12_CSE1L_FRAP1_SESN2 | |
CSE1L_UVRAG | CASP8_TKT_SESN2 | ATG7_TKT_XIAP_SESN2 | |
RAPTOR_SESN2 | DIABLO_TKT_SESN2 | ATG7_E2F1_TKT_SESN2 | |
XIAP_SESN2 | FAS_BHLHE41_SESN2 | ATG7_TKT_MMP9_SESN2 | |
CASP3_SESN2 | FRAP1_TKT_SESN2 | ATG7_TKT_RAGE_SESN2 | |
CASP8_SESN2 | PTEN_TKT_SESN2 | ATG3_ATG7_TKT_SESN2 | |
LC3_SESN2 | TKT_RAGE_SESN2 | ATG7_CSE1L_LC3_SESN2 |
五种的组合 | 六种的组合 |
ATG5_CSE1L_FRAP1_LC3_SESN2 | ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
CSE1L_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 |
ATG5_FRAP1_LC3_SESN2_SIRT1 | ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_SESN2_SIRT1 | ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 |
ATG7_CSE1L_FRAP1_LC3_SESN2 | ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG7_FRAP1_LC3_SESN2_SIRT1 | ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_LAMP1_SESN2 | ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 |
AKT1_ATG7_TKT_LAMP2_SESN2 | ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 |
ATG5_FRAP1_LAMP1_SESN2_SIRT1 | ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 |
CSE1L_FRAP1_LAMP1_SESN2_SIRT1 | CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 |
ATG3_FRAP1_LC3_SESN2_SIRT1 | AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2 |
AKT1_ATG5_CSE1L_FRAP1_SESN2 | ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 |
ATG5_CSE1L_DIABLO_FRAP1_SESN2 | ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 |
ATG5_CSE1L_LC3_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 |
CSE1L_FRAP1_SESN2_SIRT1_UVRAG | CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG |
ATG7_TKT_LAMP2_SESN2_SESN3 | AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
CSE1L_FRAP1_SATB1_SESN2_SIRT1 | ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 |
CSE1L_FRAP1_CDH1_SESN2_SIRT1 | CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG7_TKT_FASLG_LAMP2_SESN2 | ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG5_CSE1L_FRAP1_ID2_SESN2 | CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 |
AKT1_ATG7_TKT_SESN2_SESN3 | CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 |
ATG7_TKT_LAMP2_MMP2_SESN2 | CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 |
AKT1_CSE1L_FRAP1_SESN2_SIRT1 | AKT1_ATG5_FRAP1_LC3_SESN2_SIRT1 |
BNIP3_CSE1L_FRAP1_LC3_SESN2 | ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2 |
ATG5_CSE1L_FRAP1_SESN2_SESN3 | ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 |
CSE1L_FRAP1_LAMP1_LC3_SESN2 | ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1 |
ATG3_ATG5_CSE1L_FRAP1_SESN2 | ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 |
CSE1L_DRAM_FRAP1_LC3_SESN2 | ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 |
ATG3_CSE1L_FRAP1_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2 |
ATG5_ATG7_FRAP1_LC3_SESN2 | ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2 |
ATG5_FAS_FRAP1_SESN2_SIRT1 | CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 |
CSE1L_FRAP1_SESN2_SESN3_SIRT1 | BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
CSE1L_DRAM_FRAP1_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG |
CSE1L_DIABLO_FRAP1_SESN2_SIRT1 | ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2 |
ATG7_CSE1L_FRAP1_SESN2_SIRT1 | ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_CDH1_SESN2 | ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1 |
ATG7_TKT_FASLG_SESN2_SESN3 | ATG5_CSE1L_FRAP1_CDH1_SESN2_SIRT1 |
ATG7_TKT_HMGB1_LAMP2_SESN2 | ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 |
ATG7_TKT_AGER_LAMP2_SESN2 | ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2 |
ATG3_ATG5_FRAP1_LC3_SESN2 | ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG |
ATG3_ATG5_FRAP1_SESN2_SIRT1 | ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_SATB1_SESN2 | ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1 |
CSE1L_FRAP1_ID2_SESN2_SIRT1 | CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 |
ATG7_BNIP3_TKT_LAMP2_SESN2 | ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3 |
ATG5_ATG7_CSE1L_FRAP1_SESN2 | AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2 |
ATG5_LC3_NAMPT_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG |
ATG12_ATG5_CSE1L_FRAP1_SESN2 | CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 |
CSE1L_FRAP1_SESN2_SIRT1_STAT3 | CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 |
CSE1L_FRAP1_LC3_SESN2_UVRAG | ATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2 |
AKT1_ATG7_TKT_MMP2_SESN2 | AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1 |
ATG5_BNIP3_CSE1L_FRAP1_SESN2 | ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2 |
CSE1L_FRAP1_MMP9_SESN2_SIRT1 | CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 |
BNIP3_CSE1L_FRAP1_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2 |
AKT1_ATG7_TKT_HMGB1_SESN2 | ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2 |
AIFM1_AKT1_ATG7_TKT_SESN2 | ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1 |
AKT1_ATG5_ATG7_TKT_SESN2 | ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1 |
ATG12_ATG7_TKT_LAMP2_SESN2 | ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1 |
CDH1_ID2_MMP9_TCF3_SESN2 | TKT_CDH1_ID2_MMP9_TCF3_SESN2 |
七种的组合 | 八种的组合 |
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 |
ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 | AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2 |
ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG | ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 |
AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 | AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 | ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 | ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG |
ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG |
ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 | AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 |
ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 | ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG |
ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 | ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 |
ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 | AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 | ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAG |
AKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 |
ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 | AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2 |
ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 | AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2 |
ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 | AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG |
AIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 | ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAG |
ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 | AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 |
AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 | AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 | AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 | AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2 |
ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 | ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 |
ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1 |
ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 | ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAG |
ATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 | AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2 |
ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG | ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 | ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAG |
ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LC3_ID2SESN2_SIRT1_UVRAG |
ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG | ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 |
ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 | ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 |
AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 | ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1 |
ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 | AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 |
ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 | AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 |
ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 | AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1 |
ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 | AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 |
ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 | ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1 |
ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 | ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1 |
ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG | ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 |
AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 | ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 | ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1 |
AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2 | ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 | ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1 |
ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 | ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 |
ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 | ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 |
ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG | ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 |
ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 | AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 |
AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 | ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 |
ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 | ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1 |
ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 | ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 |
AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 | AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1 |
AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 | ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 |
ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 | ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 |
ATG7_TKT_CDH1_ID2MMP9_TCF3_SESN2 | TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1 |
优选的是,所述组合物或试剂盒用于预测B组的复发预后,并且所述基因是选自下表10所示的基因或基因的组中的一种或多种。
[表10]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
HMGB1 | ATG3_HMGB1 | ATG3_BCL2_HMGB1 | ATG3_BCL2_CDH1_HMGB1 |
TKT | ATG3_BECN1 | ATG3_HMGB1_RAGE | ATG3_CDH1_HMGB1_UVRAG |
TKT_HMGB1 | ATG3_TKT_HMGB1 | ATG3_BCL2_TKT_HMGB1 | |
BCL2L1_TKT | ATG3_CDH1_HMGB1 | ATG3_BCL2_HMGB1_RAGE | |
ATG3_NAMPT | ATG3_HMGB1_HMGB2 | ATG3_BCL2_HMGB1_HMGB2 | |
BCL2_HMGB1 | ATG3_HMGB1_UVRAG | ATG3_CDH1_HMGB1_SIRT1 | |
HMGB1_TWIST1 | ATG3_CASP3_HMGB1 | ATG3_BCL2_HMGB1_MMP2 | |
ATG12_ATG3 | ATG3_HMGB1_SIRT1 | ATG3_HMGB1_HMGB2_RAGE | |
CSE1L_DIABLO | ATG3_BECN1_SATB1 | ATG3_BCL2_BNIP3_HMGB1 | |
ATG3_TKT | ATG3_HMGB1_SATB1 | ATG3_CDH1_CASP3_HMGB1 | |
LAMP1_HMGB1 | ATG3_LC3_BECN1 | ATG3_CDH1_HMGB1_KIAA1967 | |
TKT_BECN1 | ATG3_HMGB1_LAMP2 | ATG3_HMGB1_RAGE_UVRAG |
CDH1_HMGB1 | ATG3_HMGB1_RAPTOR | ATG3_HMGB1_RAGE_SIRT1 | |
HMGB1_TP63 | ATG3_HMGB1_KIAA1967 | ATG3_TKT_HMGB1_HMGB2 | |
TKT_NAMPT | BCL2L1_TKT_CASP3 | ATG3_TKT_HMGB1_UVRAG | |
BCL2_TKT | ATG12_ATG3_HMGB1 | ATG3_BCL2_LAMP1_HMGB1 | |
CSE1L_TKT | BCL2L1_TKT_SIRT1 | ATG3_BCL2_HMGB1_RAPTOR | |
LC3_TKT | ATG3_CIAP2_HMGB1 | AIFM1_ATG3_BCL2_HMGB1 | |
TKT_CASP3 | BCL2L1_TKT_BECN1 | ATG3_CASP3_HMGB1_RAGE | |
FASLG_HMGB1 | BCL2_TKT_HMGB1 | ATG12_ATG3_HMGB1_RAGE | |
CDH2_HMGB1 | ATG3_BECN1_SESN3 | ATG3_TKT_CASP3_HMGB1 | |
ATG5_HMGB1 | ATG3_CASP8_HMGB1 | ATG3_TKT_HMGB1_KIAA1967 | |
HMGB1_SIRT1 | ATG3_CDH2_HMGB1 | ATG3_BCL2L1_TKT_BECN1 | |
ATG12_HMGB1 | ATG3_FRAP1_HMGB1 | ATG12_ATG3_CDH1_HMGB1 | |
HMGB1_RAGE | ATG3_BNIP3_HMGB1 | ATG3_CDH1_HMGB1_RAGE | |
HMGB1_UVRAG | ATG3_BECN1_HMGB1 | ATG3_BCL2_FRAP1_HMGB1 | |
BCL2L1_SIRT1 | ATG3_CBS_HMGB1 | ATG3_BCL2_HMGB1_LAMP2 | |
ATG3_TCF3 | AIFM1_ATG3_HMGB1 | ATG3_BCL2_DIABLO_HMGB1 | |
BCL2L1_HMGB1 | ATG3_HMGB1_STAT3 | ATG3_TKT_HMGB1_SIRT1 | |
TKT_SIRT1 | ATG3_HMGB1_MMP2 | ATG3_BCL2_CBS_HMGB1 | |
HMGB1_LAMP2 | ATG3_LAMP1_HMGB1 | ATG3_BCL2_CASP8_HMGB1 | |
TKT_SESN2 | BCL2L1_TKT_FASLG | ATG3_HMGB1_HMGB2_SATB1 | |
HMGB1_MMP2 | ATG3_DIABLO_HMGB1 | ATG3_BCL2_PTEN_HMGB1 | |
TKT_AGER | BCL2_BCL2L1_TKT | ATG3_HMGB1_RAGE_RAPTOR | |
HMGB1_RAPTOR | TKT_HMGB1_TWIST1 | ATG3_TKT_HMGB1_RAGE | |
E2F1_HMGB1 | ATG3_NNMT_HMGB1 | ATG3_BCL2_CASP3_HMGB1 | |
CASP8_HMGB1 | ATG3_MMP9_HMGB1 | ATG3_BCL2_HMGB1_SATB1 | |
TKT_ID2 | BCL2L1_TKT_HMGB1 | ATG3_HMGB1_LAMP2_RAGE | |
AKT1_TKT | ATG3_LAMP1_BECN1 | ATG3_CDH1_HMGB1_LAMP2 | |
ATG3_SIRT1 | ATG3_BCL2L1_BECN1 | ATG3_HMGB1_HMGB2_UVRAG | |
TKT_RPS19BP1 | ATG5_TKT_HMGB1 | ATG3_BCL2L1_TKT_HMGB1 | |
CSE1L_HMGB1 | ATG3_FASLG_HMGB1 | CDH1_HMGB1_TP63_UVRAG | |
BCL2L1_BECN1 | ATG3_MMP9_BECN1 | ATG3_CDH1_HMGB1_HMGB2 | |
CASP3_HMGB1 | ATG3_ATG7_BECN1 | ATG3_BCL2L1_TKT_CASP3 | |
ATG7_HMGB1 | ATG3_HMGB1_SESN3 | ATG3_HMGB1_KIAA1967_RAGE | |
FRAP1_HMGB1 | ATG3_E2F1_HMGB1 | ATG3_BCL2_DRAM_HMGB1 | |
HMGB1_HMGB2 | HMGB1_RAPTOR_TWIST1 | ATG3_LC3_TKT_HMGB1 | |
HMGB1_SATB1 | AKT1_ATG3_BECN1 | ATG3_BCL2_HMGB1_UVRAG | |
ATG3_ULK1 | ATG3_FAS_HMGB1 | ATG3_CDH1_CDH2_HMGB1 | |
ATG3_SESN1 | ATG3_ULK1_HMGB1 | BCL2_BCL2L1_TKT_CASP3 | |
CBS_HMGB1 | TKT_HMGB1_SIRT1 | ATG3_TKT_BECN1_HMGB1 | |
TKT_KIAA1967 | ATG3_BAX_HMGB1 | ATG3_TKT_HMGB1_LAMP2 | |
ATG12_BCL2L1 | TKT_CDH2_HMGB1 | ATG3_BCL2_PRKAA1_HMGB1 | |
DRAM_HMGB1 | ATG3_PTEN_HMGB1 | BCL2L1_TKT_CASP3_SIRT1 | |
LC3_FASLG | ATG3_TKT_BECN1 | BCL2L1_TKT_CASP3_FASLG | |
HMGB1_KIAA1967 | ATG3_HMGB1_TWIST1 | BCL2L1_TKT_CASP3_CDH2 | |
TKT_SESN1 | BCL2L1_TKT_UVRAG | ATG3_BCL2_NNMT_HMGB1 |
五种的组合 | 六种的组合 |
ATG3_BCL2_CDH1_HMGB1_RAGE | ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_UVRAG | ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE |
ATG3_BCL2_CDH1_HMGB1_SIRT1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE |
ATG3_BCL2_CDH1_HMGB1_RAPTOR | ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE |
ATG3_BCL2_CDH1_HMGB1_HMGB2 | ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_KIAA1967 | ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR |
ATG3_BCL2_BNIP3_CDH1_HMGB1 | ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE |
ATG3_BCL2_CDH1_HMGB1_LAMP2 | ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG |
ATG3_BCL2_CDH1_CDH2_HMGB1 | ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE |
ATG3_CDH1_HMGB1_RAGE_SIRT1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_CASP3_HMGB1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG |
ATG12_ATG3_BCL2_CDH1_HMGB1 | ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE |
AIFM1_ATG3_BCL2_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG |
ATG3_BCL2_CASP8_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE |
ATG3_BCL2_FRAP1_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2 |
ATG3_BCL2_CBS_CDH1_HMGB1 | ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2 |
ATG3_CDH1_HMGB1_RAGE_UVRAG | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 |
ATG3_BCL2_TKT_HMGB1_HMGB2 | AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG |
ATG3_BCL2_CDH1_HMGB1_MMP2 | ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967 |
ATG3_BCL2_NNMT_CDH1_HMGB1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2 |
ATG3_BCL2_HMGB1_HMGB2_RAGE | ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_CDH1_MMP9_HMGB1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR |
ATG12_ATG3_CDH1_HMGB1_RAGE | ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1 |
ATG3_CDH1_HMGB1_LAMP2_SIRT1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2 |
ATG3_BCL2_DIABLO_CDH1_HMGB1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE |
ATG3_BCL2L1_TKT_BECN1_CASP3 | ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967 |
ATG3_BCL2_HMGB1_MMP2_RAGE | ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE |
ATG3_CDH1_HMGB1_HMGB2_UVRAG | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2 |
ATG3_BCL2_DRAM_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1 |
ATG3_BCL2_TKT_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG |
ATG3_BCL2_TKT_CASP3_HMGB1 | ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE |
ATG3_CDH1_HMGB1_KIAA1967_UVRAG | ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1 |
ATG3_CDH1_HMGB1_LAMP2_UVRAG | ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG |
ATG3_BCL2_BCL2L1_TKT_HMGB1 | ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_SATB1 | ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1 |
ATG3_BCL2L1_TKT_HMGB1_SIRT1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_TKT_ID2_HMGB1 | ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE |
ATG3_CDH1_HMGB1_KIAA1967_RAGE | AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967 |
ATG3_BCL2_PTEN_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR |
AIFM1_ATG3_CDH1_HMGB1_SIRT1 | ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG |
ATG3_BCL2_CDH1_HMGB1_STAT3 | ATG3_BCL2_CBS_CDH1_HMGB1_RAGE |
ATG3_CDH1_CASP3_HMGB1_RAGE | ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG |
ATG3_BCL2_LC3_TKT_HMGB1 | ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG |
ATG3_CDH1_CASP3_HMGB1_UVRAG | ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1 |
ATG3_BCL2_CDH1_CIAP2_HMGB1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR |
ATG3_BCL2_BNIP3_HMGB1_RAGE | ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR |
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3 |
ATG3_CDH1_HMGB1_SIRT1_UVRAG | ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG |
ATG3_CDH1_HMGB1_RAPTOR_UVRAG | ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2 |
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 | ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2 |
ATG3_BAX_BCL2_CDH1_HMGB1 | ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_LAMP1_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1 |
ATG3_ATG5_BCL2_CDH1_HMGB1 | AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_TKT_HMGB1_RAGE | ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2 |
ATG3_CDH1_HMGB1_SATB1_UVRAG | ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_SESN3 | ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG |
ATG3_BCL2_FAS_CDH1_HMGB1 | ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG |
CDH1_ID2_MMP9_TCF3_FASLG | ATG12_ATG3_CDH1_ID2_MMP9_TCF3 |
七种的组合 | 八种的组合 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2 |
ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR | ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG |
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1 |
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE | ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE |
ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 | ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG | ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 | ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 | AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 | ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE | ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1 |
ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE | ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE |
ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_BCL2L1_TKT_ID2CASP3_HMGB2_UVRAG |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 | ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1 |
ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 | ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1 |
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 |
ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE |
ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE | ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967 |
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE | ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE |
AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE | ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 | ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE |
AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE | ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 |
ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG |
ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE |
ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 | ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG |
ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1 |
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967 |
AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE | ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE |
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR | ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG |
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1 |
ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE | AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG | ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG |
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 |
ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE | ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG | ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 | ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967 |
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR |
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE |
ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR |
ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE | ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG |
ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 | ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1 |
ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG |
ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE | ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE |
ATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 | ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG |
优选的是,所述组合物或试剂盒用于预测B组的存活预后,并且所述基因是选自下表11所示的基因或基因的组中的一种或多种。
[表11]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
ATG12 | DIABLO_NAMPT | DIABLO_ID2_NAMPT | ATG12_ID2_MMP9_TCF3 |
DIABLO | ATG12_ID2 | DIABLO_FAS_NAMPT | DIABLO_FAS_ID2_NAMPT |
UVRAG | ATG12_RPS19BP1 | ATG12_ID2_TCF3 | ATG12_CSE1L_ID2_MMP9 |
NAMPT | ATG12_DIABLO | DIABLO_FAS_STAT3 | DIABLO_ID2_MMP9_NAMPT |
STAT3 | ID2_NAMPT | ATG12_ID2_MMP9 | DIABLO_FAS_MMP9_NAMPT |
E2F1 | DIABLO_STAT3 | ATG12_ID2_SATB1 | DIABLO_ID2_NAMPT_STAT3 |
BECN1 | DIABLO_FAS | ATG12_ID2_RPS19BP1 | ATG12_FAS_ID2_MMP9 |
FRAP1 | ATG12_CSE1L | ATG12_CSE1L_ID2 | ATG12_ID2_MMP9_SATB1 |
ATG7 | ATG12_MMP9 | ATG12_DIABLO_FAS | DIABLO_ID2_NAMPT_SATB1 |
ID2 | ATG12_ATG3 | ATG12_ID2_SESN2 | ATG12_ID2_MMP9_SESN2 |
SIRT1 | ATG12_SATB1 | ATG12_ID2_NAMPT | ATG12_ID2_MMP9_RPS19BP1 |
BCL2 | ATG12_SESN2 | ATG12_CSE1L_DIABLO | CSE1L_DIABLO_ID2_NAMPT |
BNIP3 | CSE1L_DIABLO | ID2_NAMPT_STAT3 | DIABLO_ID2_TCF3_NAMPT |
LAMP2 | ATG12_TCF3 | ATG12_ID2_BHLHE41 | DIABLO_FAS_NAMPT_SATB1 |
TKT | ATG12_FAS | CSE1L_DIABLO_NAMPT | ATG12_DIABLO_FAS_MMP9 |
ATG12_STAT3 | DIABLO_LC3_NAMPT | DIABLO_FAS_ID2_STAT3 | |
ATG12_BHLHE41 | ATG12_FAS_ID2 | ATG12_ATG3_ID2_TCF3 | |
ATG12_NAMPT | ID2_NAMPT_RPS19BP1 | ATG3_DIABLO_ID2_NAMPT | |
ATG12_ATG7 | ID2_MMP9_TCF3 | ATG12_ID2_TCF3_STAT3 | |
ID2_BECN1 | DIABLO_NAMPT_SATB1 | DIABLO_FAS_NAMPT_STAT3 | |
E2F1_FAS | ATG12_CSE1L_MMP9 | ATG12_CSE1L_DIABLO_MMP9 | |
ATG12_ATG5 | ATG12_MMP9_RPS19BP1 | ATG12_ID2_TCF3_SATB1 | |
ID2_STAT3 | ID2_MMP9_BECN1 | DIABLO_FAS_MMP9_STAT3 | |
ATG12_ULK1 | DIABLO_NAMPT_STAT3 | ATG12_ID2_MMP9_BHLHE41 | |
DIABLO_BECN1 | ATG12_DIABLO_MMP9 | ATG12_BNIP3_ID2_MMP9 | |
ATG12_LAMP1 | ATG12_FAS_RPS19BP1 | DIABLO_FAS_SATB1_STAT3 | |
ATG12_LC3 | DIABLO_FAS_MMP9 | DIABLO_FAS_NAMPT_RPS19BP1 | |
DIABLO_TCF3 | ID2_MMP9_NAMPT | ATG12_ATG3_ID2_MMP9 | |
AKT1_ATG12 | ATG12_ID2_STAT3 | ATG12_ID2_MMP9_NAMPT | |
ATG12_FRAP1 | ATG12_DIABLO_TCF3 | DIABLO_FAS_NAMPT_SESN2 | |
DIABLO_ID2 | ATG12_ATG3_ID2 | DIABLO_ID2_NAMPT_SESN2 | |
ID2_TCF3 | ATG12_DIABLO_ID2 | ATG12_ID2_TCF3_RPS19BP1 | |
DIABLO_SATB1 | CSE1L_DIABLO_STAT3 | ATG12_DIABLO_MMP9_TCF3 | |
ATG12_BECN1 | DIABLO_ID2_STAT3 | ATG12_CSE1L_ID2_SATB1 | |
ATG12_SIRT1 | ATG12_ATG3_RPS19BP1 | ATG12_FAS_MMP9_RPS19BP1 | |
NAMPT_STAT3 | ATG12_DIABLO_SATB1 | ID2_MMP9_TCF3_STAT3 | |
ATG12_BNIP3 | ATG12_MMP9_TCF3 | ATG12_DIABLO_ID2_NAMPT | |
DIABLO_MMP9 | ATG3_DIABLO_NAMPT | DIABLO_ID2_TCF3_STAT3 | |
ATG12_UVRAG | ATG12_DIABLO_NAMPT | ATG12_ULK1_ID2_TCF3 | |
DIABLO_FRAP1 | ATG12_CSE1L_RPS19BP1 | ATG12_ID2_TCF3_SESN2 | |
NAMPT_RPS19BP1 | DIABLO_MMP9_NAMPT | BNIP3_CSE1L_DIABLO_MMP9 | |
AKT1_NAMPT | ATG12_ATG3_DIABLO | ATG12_DIABLO_ID2_TCF3 | |
E2F1_UVRAG | DIABLO_SATB1_STAT3 | ATG12_ATG5_ID2_MMP9 | |
ATG3_DIABLO | ID2_TCF3_STAT3 | ATG12_ID2_SATB1_STAT3 | |
NAMPT_UVRAG | ATG12_RPS19BP1_SATB1 | ATG12_MMP9_TCF3_RPS19BP1 | |
BNIP3_DIABLO | ATG12_DIABLO_STAT3 | ATG12_DIABLO_FAS_ID2 | |
DIABLO_LC3 | ATG12_TCF3_RPS19BP1 | ATG12_CSE1L_ID2_SESN2 | |
DIABLO_SIRT1 | DIABLO_NAMPT_SESN2 | DIABLO_FAS_MMP9_TCF3 | |
LC3_NAMPT | ATG12_DIABLO_SESN2 | ATG12_ID2_TCF3_BHLHE41 | |
DIABLO_SESN2 | ATG12_ULK1_ID2 | ATG12_FAS_ID2_STAT3 | |
FAS_STAT3 | ATG12_ATG5_ID2 | BNIP3_CSE1L_ID2_MMP9 | |
FAS_NAMPT | AKT1_DIABLO_NAMPT | CSE1L_DIABLO_FAS_NAMPT | |
E2F1_NAMPT | ATG12_ID2_BECN1 | ATG12_CSE1L_ID2_TCF3 | |
ATG12_SESN3 | ATG12_FAS_MMP9 | ATG12_ID2_NAMPT_RPS19BP1 | |
BCL2_TKT | ATG12_DIABLO_BHLHE41 | ATG12_ID2_MMP9_BECN1 | |
ATG7_NAMPT | ATG12_RPS19BP1_STAT3 | DIABLO_FAS_LC3_NAMPT | |
ATG7_BECN1 | DIABLO_NAMPT_RPS19BP1 | FAS_ID2_NAMPT_RPS19BP1 | |
CDH1_ID2_MMP9_TCF3 |
五种的组合 | 六种的组合 |
DIABLO_FAS_ID2_MMP9_NAMPT | DIABLO_FAS_ID2_MMP9_TCF3_NAMPT |
ATG12_ATG3_ID2_MMP9_TCF3 | ATG12_ATG3_BNIP3_ID2_MMP9_TCF3 |
ATG12_ID2_MMP9_TCF3_SATB1 | ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1 |
ATG12_CSE1L_ID2_MMP9_TCF3 | ATG12_ATG3_ID2_MMP9_TCF3_SATB1 |
ATG12_BNIP3_ID2_MMP9_TCF3 | DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 |
ATG12_ID2_MMP9_TCF3_SESN2 | ATG12_ATG3_ULK1_ID2_MMP9_TCF3 |
ATG12_ULK1_ID2_MMP9_TCF3 | ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2 |
ATG12_ATG5_ID2_MMP9_TCF3 | DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 |
ATG12_FAS_ID2_MMP9_TCF3 | ATG12_ATG3_FAS_ID2_MMP9_TCF3 |
DIABLO_FAS_ID2_NAMPT_STAT3 | ATG12_ATG3_ID2_MMP9_TCF3_SESN2 |
ATG12_ID2_MMP9_TCF3_RPS19BP1 | ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3 |
ATG12_BNIP3_ID2_MMP9_RPS19BP1 | CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT |
ATG12_CSE1L_ID2_MMP9_SATB1 | ATG12_ATG3_CSE1L_ID2_MMP9_TCF3 |
ATG12_CSE1L_ID2_MMP9_SESN2 | ATG12_BNIP3_ID2_MMP9_TCF3_SATB1 |
ATG12_LAMP1_ID2_MMP9_TCF3 | DIABLO_FAS_ID2_MMP9_NAMPT_SESN2 |
DIABLO_FAS_ID2_NAMPT_SATB1 | ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41 |
ATG12_BNIP3_CSE1L_ID2_MMP9 | ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1 |
DIABLO_ID2_MMP9_TCF3_NAMPT | DIABLO_FAS_ID2_MMP9_TCF3_STAT3 |
ATG12_BNIP3_ID2_MMP9_SATB1 | ATG12_ATG3_BNIP3_FAS_ID2_MMP9 |
ATG12_ID2_MMP9_TCF3_BHLHE41 | ATG12_ATG3_BNIP3_ID2_MMP9_SATB1 |
ATG12_ID2_MMP9_TCF3_STAT3 | ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 |
ATG12_BNIP3_FAS_ID2_MMP9 | ATG12_BNIP3_DIABLO_FAS_ID2_MMP9 |
ATG12_BNIP3_ID2_MMP9_SESN2 | ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1 |
ATG12_ATG3_FAS_ID2_MMP9 | ATG12_CSE1L_ID2_MMP9_TCF3_SATB1 |
CSE1L_DIABLO_ID2_MMP9_NAMPT | ATG12_CSE1L_ULK1_ID2_MMP9_TCF3 |
ATG12_DIABLO_ID2_MMP9_TCF3 | ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1 |
DIABLO_ID2_NAMPT_SATB1_STAT3 | DIABLO_FAS_ID2_NAMPT_SATB1_STAT3 |
ATG12_ATG3_CSE1L_ID2_MMP9 | ATG12_ATG5_BNIP3_ID2_MMP9_TCF3 |
ATG12_FAS_ID2_MMP9_RPS19BP1 | ATG12_BNIP3_ID2_MMP9_TCF3_SESN2 |
ATG12_DIABLO_FAS_ID2_MMP9 | ATG12_CSE1L_ID2_MMP9_TCF3_SESN2 |
DIABLO_FAS_ID2_MMP9_STAT3 | ATG12_ID2_MMP9_TCF3_SATB1_SESN2 |
ATG12_CSE1L_ID2_MMP9_BHLHE41 | ATG12_ULK1_ID2_MMP9_TCF3_SATB1 |
DIABLO_ID2_MMP9_NAMPT_STAT3 | ATG12_ATG3_ATG5_ID2_MMP9_TCF3 |
DIABLO_FAS_ID2_NAMPT_SESN2 | ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9 |
ATG12_CSE1L_FAS_ID2_MMP9 | ATG12_ATG3_LAMP1_ID2_MMP9_TCF3 |
DIABLO_FAS_ID2_TCF3_NAMPT | ATG12_BNIP3_DIABLO_ID2_MMP9_TCF3 |
ATG12_ATG3_ID2_MMP9_SATB1 | ATG12_BNIP3_ULK1_ID2_MMP9_TCF3 |
ATG12_BNIP3_ID2_MMP9_BHLHE41 | ATG12_DIABLO_FAS_ID2_MMP9_TCF3 |
ATG3_DIABLO_FAS_ID2_NAMPT | ATG12_ULK1_ID2_MMP9_TCF3_SESN2 |
CSE1L_DIABLO_FAS_ID2_NAMPT | ATG3_DIABLO_FAS_ID2_MMP9_NAMPT |
ATG12_CSE1L_ID2_MMP9_RPS19BP1 | ATG12_ATG3_BNIP3_ID2_MMP9_SESN2 |
ATG12_CSE1L_ULK1_ID2_MMP9 | ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41 |
DIABLO_FAS_ID2_MMP9_TCF3 | ATG12_BNIP3_CSE1L_FAS_ID2_MMP9 |
CSE1L_DIABLO_ID2_NAMPT_STAT3 | DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1 |
ATG12_ATG3_ID2_MMP9_SESN2 | ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1 |
DIABLO_ID2_MMP9_TCF3_STAT3 | ATG12_ATG5_ID2_MMP9_TCF3_SATB1 |
DIABLO_ID2_TCF3_NAMPT_SATB1 | ATG12_BNIP3_FAS_ID2_MMP9_TCF3 |
CSE1L_DIABLO_FAS_MMP9_NAMPT | ATG12_ATG3_CSE1L_ID2_MMP9_SATB1 |
DIABLO_FAS_ID2_NAMPT_RPS19BP1 | ATG12_ATG3_ID2_MMP9_TCF3_STAT3 |
BNIP3_DIABLO_FAS_ID2_MMP9 | ATG12_ATG5_BNIP3_ID2_MMP9_SATB1 |
DIABLO_ID2_MMP9_NAMPT_SATB1 | ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41 |
ATG12_DIABLO_FAS_MMP9_TCF3 | ATG12_FAS_ID2_MMP9_TCF3_SESN2 |
ATG12_ATG5_FAS_ID2_MMP9 | DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1 |
ATG12_LC3_ID2_MMP9_TCF3 | ATG12_ATG3_CSE1L_ID2_MMP9_SESN2 |
ATG12_FAS_ID2_MMP9_STAT3 | ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1 |
FAS_ID2_MMP9_NAMPT_RPS19BP1 | ATG12_ATG5_BNIP3_FAS_ID2_MMP9 |
ATG12_ID2_MMP9_TCF3_BECN1 | ATG12_ATG5_ULK1_ID2_MMP9_TCF3 |
ATG12_CDH1_ID2_MMP9_TCF3 | E2F1_FAS_CDH1_ID2_MMP9_TCF3 |
七种的组合 | 八种的组合 |
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 | ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 |
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 | ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 |
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 | ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 |
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 | ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 |
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 | DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3 |
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 | DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2 |
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 | ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 |
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 | ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 |
ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 | ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 |
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 | ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 |
ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 | ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 |
DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 | ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 |
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 | ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 |
ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 | ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 |
ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 | ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 |
ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3 | ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1 |
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 | ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 |
ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 | ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 |
ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 | ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 |
ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 | ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_BHLHE41 |
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 | ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1 |
ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 | ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1 |
ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 | ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2 |
DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 | ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1 |
ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 | ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 |
ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 | ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2 |
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 | ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2 |
ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 | ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1 |
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 | ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1 |
CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 | ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1 |
ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 | CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 |
ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 | ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3 |
ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 | ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2 |
ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 | ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3 |
ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 | ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 |
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 | ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1 |
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 | ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2 |
ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 | ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1 |
ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 | ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2 |
ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 | ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1 |
ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 | ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3 |
ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 | ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 |
ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 | ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 |
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 | ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2 |
ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 | ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1 |
ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 | ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2 |
ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 | ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_TCF3 |
ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 | ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2 |
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 | ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 |
ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 | DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3 |
ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 | DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3 |
DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 | ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9 |
CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT | ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41 |
DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 | ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3 |
CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 | ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1 |
ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 | ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1 |
ATG12_ATG3_BNIP3_FAS_ID2MMP9_SATB1 | ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2 |
ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG | ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG |
优选的是,所述组合物或试剂盒用于预测B组的无病存活预后,并且所述基因是选自下表12所示的基因或基因的组中的一种或多种。
[表12]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
DIABLO | ATG3_BECN1 | ATG3_BCL2_HMGB1 | ATG3_BCL2_CDH1_HMGB1 |
BECN1 | ATG3_HMGB1 | ATG3_HMGB1_RAGE | ATG3_CDH1_HMGB1_UVRAG |
HMGB1 | BCL2L1_TKT | ATG3_HMGB1_UVRAG | ATG3_BCL2_TKT_HMGB1 |
CSE1L_DIABLO | ATG3_CASP3_HMGB1 | ATG3_BCL2_HMGB1_RAGE | |
BCL2_HMGB1 | ATG3_HMGB1_SIRT1 | ATG3_BCL2_HMGB1_HMGB2 | |
ATG12_ATG3 | ATG3_BECN1_SATB1 | ATG3_CDH1_HMGB1_SIRT1 | |
ATG3_NAMPT | ATG3_HMGB1_LAMP2 | ATG3_BCL2_HMGB1_MMP2 |
HMGB1_TWIST1 | ATG3_HMGB1_RAPTOR | ATG3_HMGB1_HMGB2_RAGE | |
TKT_HMGB1 | ATG3_LC3_BECN1 | ATG3_BCL2_BNIP3_HMGB1 | |
LAMP1_HMGB1 | ATG3_HMGB1_KIAA1967 | ATG3_CDH1_CASP3_HMGB1 | |
TKT_BECN1 | BCL2L1_TKT_CASP3 | ATG3_CDH1_HMGB1_KIAA1967 | |
HMGB1_TP63 | ATG12_ATG3_HMGB1 | ATG3_HMGB1_RAGE_UVRAG | |
BCL2_TKT | BCL2L1_TKT_SIRT1 | ATG3_HMGB1_RAGE_SIRT1 | |
TKT_CASP3 | BCL2L1_TKT_BECN1 | ATG3_TKT_HMGB1_UVRAG | |
FASLG_HMGB1 | BCL2_TKT_HMGB1 | ATG3_BCL2_LAMP1_HMGB1 | |
TKT_NAMPT | ATG3_BECN1_SESN3 | ATG3_BCL2_HMGB1_RAPTOR | |
ATG5_HMGB1 | ATG3_BNIP3_HMGB1 | AIFM1_ATG3_BCL2_HMGB1 | |
HMGB1_SIRT1 | ATG3_BECN1_HMGB1 | ATG3_CASP3_HMGB1_RAGE | |
ATG12_HMGB1 | AIFM1_ATG3_HMGB1 | ATG12_ATG3_HMGB1_RAGE | |
HMGB1_RAGE | ATG3_LAMP1_HMGB1 | ATG3_TKT_CASP3_HMGB1 | |
DIABLO_NAMPT | BCL2L1_TKT_FASLG | ATG3_TKT_HMGB1_KIAA1967 | |
HMGB1_UVRAG | BCL2_BCL2L1_TKT | ATG3_BCL2L1_TKT_BECN1 | |
DIABLO_BECN1 | TKT_HMGB1_TWIST1 | ATG12_ATG3_CDH1_HMGB1 | |
BECN1_SATB1 | ATG3_NNMT_HMGB1 | ATG3_CDH1_HMGB1_RAGE | |
BCL2L1_SIRT1 | BCL2L1_TKT_HMGB1 | ATG3_BCL2_FRAP1_HMGB1 | |
BCL2L1_HMGB1 | ATG3_BCL2L1_BECN1 | ATG3_BCL2_HMGB1_LAMP2 | |
TKT_SIRT1 | ATG5_TKT_HMGB1 | ATG3_BCL2_DIABLO_HMGB1 | |
DIABLO_TCF3 | ATG3_FASLG_HMGB1 | ATG3_TKT_HMGB1_SIRT1 | |
HMGB1_LAMP2 | ATG3_MMP9_BECN1 | ATG3_BCL2_CBS_HMGB1 | |
DIABLO_SATB1 | ATG3_LAMP1_BECN1 | ATG3_BCL2_CASP8_HMGB1 | |
HMGB1_RAPTOR | ATG3_E2F1_HMGB1 | ATG3_BCL2_PTEN_HMGB1 | |
E2F1_HMGB1 | HMGB1_RAPTOR_TWIST1 | ATG3_HMGB1_RAGE_RAPTOR | |
ATG5_BECN1 | AKT1_ATG3_BECN1 | ATG3_TKT_HMGB1_RAGE | |
ATG12_SATB1 | ATG3_ULK1_HMGB1 | ATG3_BCL2_CASP3_HMGB1 | |
BCL2L1_BECN1 | TKT_HMGB1_SIRT1 | ATG3_BCL2_HMGB1_SATB1 | |
CASP3_HMGB1 | ATG3_BAX_HMGB1 | ATG3_HMGB1_LAMP2_RAGE | |
ATG12_CSE1L | ATG3_PTEN_HMGB1 | ATG3_CDH1_HMGB1_LAMP2 | |
ATG7_HMGB1 | ATG3_TKT_HMGB1 | ATG3_HMGB1_HMGB2_UVRAG | |
ATG3_SIRT1 | ATG3_TKT_BECN1 | ATG3_BCL2L1_TKT_HMGB1 | |
CASP8_HMGB1 | ATG3_HMGB1_TWIST1 | CDH1_HMGB1_TP63_UVRAG | |
ATG3_SESN1 | BCL2L1_TKT_UVRAG | ATG3_BCL2L1_TKT_CASP3 | |
TKT_KIAA1967 | TKT_HMGB1_UVRAG | ATG3_HMGB1_KIAA1967_RAGE | |
ATG12_BCL2L1 | BCL2L1_TKT_CDH2 | ATG3_BCL2_DRAM_HMGB1 | |
DRAM_HMGB1 | BCL2L1_TKT_KIAA1967 | ATG3_BCL2_HMGB1_UVRAG | |
LC3_FASLG | ATG3_BCL2L1_HMGB1 | BCL2_BCL2L1_TKT_CASP3 | |
HMGB1_KIAA1967 | ATG3_ATG5_HMGB1 | ATG3_TKT_BECN1_HMGB1 | |
TKT_SESN1 | ATG3_DRAM_HMGB1 | ATG3_TKT_HMGB1_LAMP2 | |
ATG3_DIABLO | ATG3_HMGB1_SATB1 | ATG3_BCL2_PRKAA1_HMGB1 | |
DIABLO_SIRT1 | ATG3_BCL2L1_TKT | BCL2L1_TKT_CASP3_SIRT1 | |
BECN1_HMGB1 | ATG3_PRKAA1_HMGB1 | BCL2L1_TKT_CASP3_FASLG | |
AIFM1_HMGB1 | TKT_CASP3_HMGB1 | BCL2L1_TKT_CASP3_CDH2 | |
ID2_BECN1 | ATG3_XIAP_HMGB1 | ATG3_BCL2_NNMT_HMGB1 | |
CSE1L_BECN1 | TKT_HMGB1_KIAA1967 | ATG3_CDH1_HMGB1_RAPTOR | |
TKT_ULK1 | TKT_HMGB1_LAMP2 | ATG3_BNIP3_HMGB1_RAGE | |
BNIP3_HMGB1 | HMGB1_RAGE_TWIST1 | ATG3_BAX_BCL2_HMGB1 | |
TKT_UVRAG | ATG12_BCL2L1_TKT | ATG3_BCL2_ID2_HMGB1 | |
ATG5_TKT | ATG3_PTEN_BECN1 | ATG3_BCL2_HMGB1_STAT3 |
五种的组合 | 六种的组合 |
ATG3_BCL2_CDH1_HMGB1_RAGE | ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_UVRAG | ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE |
ATG3_BCL2_CDH1_HMGB1_SIRT1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE |
ATG3_BCL2_CDH1_HMGB1_RAPTOR | ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE |
ATG3_BCL2_CDH1_HMGB1_HMGB2 | ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_KIAA1967 | ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR |
ATG3_BCL2_BNIP3_CDH1_HMGB1 | ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE |
ATG3_BCL2_CDH1_HMGB1_LAMP2 | ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG |
ATG3_BCL2_CDH1_CDH2_HMGB1 | ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE |
ATG3_CDH1_HMGB1_RAGE_SIRT1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_CASP3_HMGB1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG |
ATG12_ATG3_BCL2_CDH1_HMGB1 | ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE |
AIFM1_ATG3_BCL2_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG |
ATG3_BCL2_CASP8_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE |
ATG3_BCL2_FRAP1_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2 |
ATG3_BCL2_CBS_CDH1_HMGB1 | ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2 |
ATG3_CDH1_HMGB1_RAGE_UVRAG | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 |
ATG3_BCL2_TKT_HMGB1_HMGB2 | AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG |
ATG3_BCL2_CDH1_HMGB1_MMP2 | ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967 |
ATG3_BCL2_NNMT_CDH1_HMGB1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2 |
ATG3_BCL2_HMGB1_HMGB2_RAGE | ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_CDH1_MMP9_HMGB1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR |
ATG12_ATG3_CDH1_HMGB1_RAGE | ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1 |
ATG3_CDH1_HMGB1_LAMP2_SIRT1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2 |
ATG3_BCL2_DIABLO_CDH1_HMGB1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE |
ATG3_BCL2L1_TKT_BECN1_CASP3 | ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967 |
ATG3_BCL2_HMGB1_MMP2_RAGE | ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE |
ATG3_CDH1_HMGB1_HMGB2_UVRAG | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2 |
ATG3_BCL2_DRAM_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1 |
ATG3_BCL2_TKT_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG |
ATG3_BCL2_TKT_CASP3_HMGB1 | ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE |
ATG3_CDH1_HMGB1_KIAA1967_UVRAG | ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1 |
ATG3_CDH1_HMGB1_LAMP2_UVRAG | ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG |
ATG3_BCL2_BCL2L1_TKT_HMGB1 | ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_SATB1 | ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1 |
ATG3_BCL2L1_TKT_HMGB1_SIRT1 | ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_TKT_ID2_HMGB1 | ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE |
ATG3_CDH1_HMGB1_KIAA1967_RAGE | AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967 |
ATG3_BCL2_PTEN_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR |
AIFM1_ATG3_CDH1_HMGB1_SIRT1 | ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG |
ATG3_BCL2_CDH1_HMGB1_STAT3 | ATG3_BCL2_CBS_CDH1_HMGB1_RAGE |
ATG3_CDH1_CASP3_HMGB1_RAGE | ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG |
ATG3_BCL2_LC3_TKT_HMGB1 | ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG |
ATG3_CDH1_CASP3_HMGB1_UVRAG | ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1 |
ATG3_BCL2_CDH1_CIAP2_HMGB1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR |
ATG3_BCL2_BNIP3_HMGB1_RAGE | ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR |
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3 |
ATG3_CDH1_HMGB1_SIRT1_UVRAG | ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG |
ATG3_CDH1_HMGB1_RAPTOR_UVRAG | ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2 |
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 | ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2 |
ATG3_BAX_BCL2_CDH1_HMGB1 | ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_LAMP1_CDH1_HMGB1 | ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1 |
ATG3_ATG5_BCL2_CDH1_HMGB1 | AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_TKT_HMGB1_RAGE | ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2 |
ATG3_CDH1_HMGB1_SATB1_UVRAG | ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_SESN3 | ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG |
ATG3_BCL2_FAS_CDH1_HMGB1 | ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG |
CDH1_ID2_MMP9_TCF3_FASLG | ATG12_ATG3_CDH1_ID2_MMP9_TCF3 |
七种的组合 | 八种的组合 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2 |
ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR | ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG |
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1 |
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE | ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE |
ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 | ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG | ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 | ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 | AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 | ATG3_BCL2L1_TKT_ID2CDH2_HMGB2_KIAA1967_TWIST1 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE | ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1 |
ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2 |
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE | ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE |
ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_BCL2L1_TKT_ID2CASP3_HMGB2_UVRAG |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 | ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1 |
ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 | ATG3_BCL2_BCL2L1_BNIP3TKT_ID2_HMGB2_SIRT1 |
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 |
ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE |
ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE | ATG3_BCL2_BCL2L1_BNIP3TKT_ID2CASP3_KIAA1967 |
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE | ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE |
AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE | ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 | ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 | ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE |
AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE | ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 |
ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG |
ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE | ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE |
ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 | ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG |
ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1 |
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG | ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967 |
AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE | ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE |
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR | ATG3_LC3TKT_HMGB1_RAGE_RAPTOR_TTWIST1_UVRAG |
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_BNIP3TKT_ID2_CASP3_SIRT1 |
ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE | AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 |
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG | ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG |
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 |
ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE | ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG | ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 |
ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 | ATG3_LC3TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG |
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967 |
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG | AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR |
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 | AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE |
ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR |
ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE | ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG |
ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 | ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1 |
ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG |
ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE | ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR |
ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE | ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE |
NNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG | ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG |
优选的是,所述组合物或试剂盒用于预测C组的复发预后,并且所述基因是选自下表13所示的基因或基因的组中的一种或多种。
[表13]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
FASLG | CIAP2_FASLG | FAS_LC3_FASLG | DIABLO_FAS_LC3_FASLG |
CIAP2 | E2F1_FASLG | DIABLO_FAS_FASLG | FAS_LC3_FASLG_UVRAG |
CSE1L | LC3_FASLG | E2F1_LC3_FASLG | BNIP3_FAS_LC3_FASLG |
FAS | DIABLO_FASLG | FAS_FASLG_RPS19BP1 | DRAM_FAS_LC3_FASLG |
TCF3 | FAS_FASLG | E2F1_FAS_FASLG | E2F1_FAS_LC3_FASLG |
FASLG_RPS19BP1 | FAS_FASLG_UVRAG | ATG3_FAS_LC3_FASLG | |
PTEN_FASLG | DIABLO_LC3_FASLG | ATG7_FAS_LC3_FASLG | |
CASP3_FASLG | ATG7_FAS_FASLG | FAS_LC3_FASLG_STAT3 | |
FASLG_SESN2 | CIAP2_FASLG_SESN3 | FAS_FRAP1_LC3_FASLG | |
FASLG_HMGB1 | CIAP2_FASLG_UVRAG | FAS_LC3_FASLG_SESN3 | |
CDH2_FASLG | BNIP3_LC3_FASLG | FAS_LC3_FASLG_SIRT1 | |
FRAP1_FASLG | LC3_CIAP2_FASLG | FAS_LC3_BECN1_FASLG | |
ATG7_FASLG | LC3_FASLG_SESN2 | ATG5_FAS_LC3_FASLG | |
ATG3_FAS | FRAP1_LC3_FASLG | FAS_LC3_FASLG_RPS19BP1 | |
FASLG_HMGB2 | LC3_FASLG_SESN3 | FAS_LAMP1_LC3_FASLG | |
FASLG_UVRAG | ATG3_FAS_FASLG | FAS_LC3_FASLG_NAMPT | |
DIABLO_FAS | ATG7_LC3_FASLG | AKT1_FAS_LC3_FASLG | |
FASLG_MMP2 | FAS_FRAP1_FASLG | FAS_LC3_FASLG_SESN2 | |
TKT_FASLG | DIABLO_FASLG_SESN2 | FAS_LC3_MMP9_FASLG | |
PTEN_CIAP2 | DRAM_LC3_FASLG | FAS_FASLG_RPS19BP1_SESN3 | |
FAS_LC3 | CIAP2_FASLG_HMGB1 | FAS_FASLG_RPS19BP1_UVRAG | |
CBS_FASLG | FAS_FASLG_SESN3 | FAS_LC3_CDH1_FASLG | |
AIFM1_FASLG | LC3_FASLG_UVRAG | ATG12_FAS_LC3_FASLG | |
CASP3_CIAP2 | CASP3_CIAP2_FASLG | DIABLO_FAS_FASLG_SESN3 | |
FASLG_SESN3 | FAS_FASLG_SESN2 | DIABLO_FAS_FASLG_UVRAG | |
ATG3_FASLG | PTEN_CIAP2_FASLG | FAS_LC3_FASLG_LAMP2 | |
CASP8_FASLG | DIABLO_FASLG_SESN3 | FAS_LC3_ID2_FASLG | |
XIAP_FASLG | ATG7_CIAP2_FASLG | DIABLO_FAS_FASLG_SESN2 | |
AGER_FASLG | LC3_FASLG_SIRT1 | FAS_LC3_BHLHE41_FASLG | |
ATG3_ULK1 | LC3_FASLG_RPS19BP1 | DIABLO_DRAM_FAS_FASLG | |
BNIP3_FASLG | FASLG_SESN2_SESN3 | DIABLO_FAS_FASLG_STAT3 | |
FAS_UVRAG | DRAM_FAS_FASLG | DRAM_FAS_FASLG_RPS19BP1 | |
CIAP2_RAGE | ID2_CIAP2_FASLG | DIABLO_FAS_FRAP1_FASLG | |
ATG3_TCF3 | FAS_FASLG_STAT3 | FAS_FASLG_SESN2_UVRAG | |
FASLG_RAGE | AKT1_CIAP2_FASLG | ATG3_FAS_FASLG_SESN2 | |
E2F1_CIAP2 | DIABLO_FRAP1_FASLG | ATG7_DIABLO_FAS_FASLG | |
FASLG_VEGF | BNIP3_FAS_FASLG | FAS_LC3_TCF3_FASLG | |
E2F1_FAS | FAS_LAMP1_FASLG | ATG7_FAS_FASLG_UVRAG | |
XIAP_CIAP2 | TKT_CIAP2_FASLG | DIABLO_FAS_FASLG_NAMPT | |
BCL2L1_FASLG | ATG7_DIABLO_FASLG | DIABLO_FAS_FASLG_SIRT1 | |
BNIP3_FAS | FRAP1_FASLG_SESN2 | DIABLO_FAS_LAMP1_FASLG | |
FASLG_SESN1 | E2F1_ULK1_FASLG | FAS_FRAP1_FASLG_RPS19BP1 | |
FASLG_KIAA1967 | DRAM_CIAP2_FASLG | CSE1L_FAS_LC3_FASLG | |
AIFM1_CIAP2 | PTEN_CASP3_FASLG | DIABLO_FAS_BECN1_FASLG | |
DRAM_FASLG | LC3_FASLG_NAMPT | E2F1_LC3_ID2_FASLG | |
ATG3_CIAP2 | PTEN_CDH1_CIAP2 | AKT1_DIABLO_FAS_FASLG | |
CSE1L_FASLG | ATG12_CIAP2_FASLG | ATG3_DIABLO_FAS_FASLG | |
FASLG_RAPTOR | FASLG_RPS19BP1_SESN3 | E2F1_FAS_FASLG_SESN3 | |
TCF3_FASLG | MMP9_CIAP2_FASLG | ATG7_FAS_FASLG_SESN2 | |
FASLG_STAT3 | LAMP1_CIAP2_FASLG | DIABLO_FAS_FASLG_RPS19BP1 | |
ULK1_FASLG | LC3_BECN1_FASLG | DRAM_FAS_FASLG_UVRAG | |
PRKAA1_CIAP2 | CDH1_CIAP2_FASLG | LC3_MMP9_FASLG_SESN2 | |
FASLG_SIRT1 | BECN1_CIAP2_FASLG | FAS_FASLG_SESN3_UVRAG | |
ATG12_FASLG | CIAP2_FASLG_HMGB2 | DIABLO_FAS_FASLG_LAMP2 | |
LAM P1_FASLG | E2F1_FASLG_LAMP2 | DIABLO_FAS_ID2_FASLG | |
NNMT_FASLG | CIAP2_FASLG_SIRT1 | E2F1_LC3_FASLG_LAMP2 | |
BCL2L1_CIAP2 | PTEN_XIAP_FASLG | E2F1_LC3_MMP9_FASLG | |
CDH1_ID2_MMP9_TCF3 |
五种的组合 | 六种的组合 |
BNIP3_DRAM_FAS_LC3_FASLG | BNIP3_DRAM_FAS_LC3_FASLG_SESN2 |
DRAM_FAS_LC3_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_FASLG_SESN3 |
DIABLO_DRAM_FAS_LC3_FASLG | ATG3_FAS_LC3_MMP9_FASLG_SESN2 |
ATG3_FAS_LC3_FASLG_SESN3 | ATG3_FAS_LC3_MMP9_FASLG_SESN3 |
BNIP3_FAS_LC3_FASLG_SESN3 | ATG3_FAS_LC3_FASLG_SESN2_SESN3 |
BNIP3_FAS_LC3_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_FASLG |
ATG3_FAS_LC3_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_FASLG_STAT3 |
BNIP3_FAS_LC3_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_FASLG_UVRAG |
DRAM_FAS_LC3_FASLG_STAT3 | BNIP3_DRAM_FAS_LC3_FASLG_SIRT1 |
DIABLO_FAS_LC3_BECN1_FASLG | ATG3_DRAM_FAS_LC3_FASLG_SESN2 |
BNIP3_DIABLO_FAS_LC3_FASLG | BNIP3_DRAM_FAS_LC3_BECN1_FASLG |
ATG7_DRAM_FAS_LC3_FASLG | DRAM_FAS_LC3_ID2_FASLG_UVRAG |
DIABLO_FAS_LC3_FASLG_STAT3 | BNIP3_FAS_LC3_MMP9_FASLG_UVRAG |
DRAM_FAS_LC3_FASLG_SIRT1 | DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 |
DRAM_E2F1_FAS_LC3_FASLG | ATG5_DRAM_FAS_LC3_FASLG_UVRAG |
DRAM_FAS_LC3_FASLG_SESN3 | DRAM_FAS_LC3_FASLG_SIRT1_UVRAG |
DRAM_FAS_LC3_BECN1_FASLG | DRAM_FAS_LC3_MMP9_FASLG_UVRAG |
BNIP3_FAS_LC3_FASLG_STAT3 | BNIP3_DRAM_FAS_LC3_ID2_FASLG |
BNIP3_FAS_LC3_MMP9_FASLG | ATG3_DRAM_FAS_LC3_FASLG_SESN3 |
DIABLO_FAS_LC3_ID2_FASLG | BNIP3_FAS_LC3_MMP9_FASLG_SESN3 |
DIABLO_FAS_LC3_MMP9_FASLG | BNIP3_FAS_LC3_MMP9_FASLG_SESN2 |
ATG5_FAS_LC3_FASLG_UVRAG | DRAM_FAS_LC3_BECN1_FASLG_UVRAG |
ATG5_DRAM_FAS_LC3_FASLG | BNIP3_DRAM_FAS_FRAP1_LC3_FASLG |
DIABLO_FAS_LC3_FASLG_SIRT1 | BNIP3_FAS_LC3_FASLG_SESN3_SIRT1 |
FAS_LC3_FASLG_SIRT1_UVRAG | DRAM_FAS_LC3_BHLHE41_FASLG_UVRAG |
DRAM_FAS_FRAP1_LC3_FASLG | BNIP3_DRAM_FAS_LC3_FASLG_LAMP2 |
DIABLO_FAS_LC3_FASLG_SESN3 | AKT1_BNIP3_DRAM_FAS_LC3_FASLG |
FAS_LC3_BECN1_FASLG_UVRAG | DIABLO_DRAM_FAS_LC3_ID2_FASLG |
ATG3_FAS_LC3_MMP9_FASLG | DRAM_FAS_LC3_FASLG_SESN3_SIRT1 |
BNIP3_FAS_LC3_FASLG_SIRT1 | ATG3_DIABLO_FAS_LC3_MMP9_FASLG |
BNIP3_FAS_FRAP1_LC3_FASLG | BNIP3_FAS_LC3_FASLG_SESN3_STAT3 |
DIABLO_FAS_LC3_FASLG_UVRAG | BNIP3_FAS_LC3_BECN1_FASLG_SESN2 |
DIABLO_FAS_LC3_FASLG_NAMPT | BNIP3_FAS_LC3_FASLG_SESN2_SIRT1 |
FAS_LC3_MMP9_FASLG_RPS19BP1 | DIABLO_DRAM_FAS_LC3_MMP9_FASLG |
BNIP3_FAS_LC3_BECN1_FASLG | BNIP3_FAS_LC3_BECN1_FASLG_SESN3 |
E2F1_FAS_LC3_MMP9_FASLG | BNIP3_FAS_LC3_FASLG_SESN2_UVRAG |
FAS_LC3_MMP9_FASLG_UVRAG | DRAM_FAS_LC3_FASLG_LAMP2_UVRAG |
ATG3_DIABLO_FAS_LC3_FASLG | ATG3_FAS_FRAP1_LC3_MMP9_FASLG |
DIABLO_FAS_LC3_BHLHE41_FASLG | DRAM_FAS_LC3_BECN1_FASLG_SESN3 |
FAS_LC3_ID2_FASLG_UVRAG | DIABLO_DRAM_FAS_LC3_BECN1_FASLG |
DIABLO_FAS_LC3_FASLG_LAMP2 | ATG3_DRAM_FAS_LC3_MMP9_FASLG |
DRAM_FAS_LC3_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_CDH1_FASLG |
DRAM_FAS_LAMP1_LC3_FASLG | DRAM_FAS_LC3_FASLG_SESN2_UVRAG |
ATG3_FAS_FRAP1_LC3_FASLG | BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG |
FAS_LC3_FASLG_STAT3_UVRAG | ATG5_DRAM_FAS_LC3_FASLG_SESN3 |
AKT1_BNIP3_FAS_LC3_FASLG | DRAM_FAS_LC3_FASLG_SESN3_STAT3 |
FAS_LC3_FASLG_SESN3_UVRAG | BNIP3_FAS_LC3_FASLG_SESN2_STAT3 |
ATG3_DRAM_FAS_LC3_FASLG | BNIP3_DIABLO_FAS_LC3_MMP9_FASLG |
AKT1_DRAM_FAS_LC3_FASLG | ATG5_DRAM_FAS_LC3_FASLG_SESN2 |
FAS_LC3_FASLG_SESN2_UVRAG | ATG5_FAS_LC3_MMP9_FASLG_UVRAG |
FAS_LC3_BHLHE41_FASLG_UVRAG | DIABLO_DRAM_FAS_LC3_BHLHE41_FASLG |
DRAM_FAS_LC3_FASLG_NAMPT | DIABLO_DRAM_FAS_LC3_FASLG_STAT3 |
FAS_LC3_FASLG_LAMP2_UVRAG | ATG3_DIABLO_FAS_LC3_FASLG_SESN3 |
ATG7_BNIP3_FAS_LC3_FASLG | DRAM_FAS_LC3_TCF3_FASLG_UVRAG |
AKT1_FAS_LC3_FASLG_UVRAG | BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1 |
E2F1_FAS_LC3_ID2_FASLG | ATG5_DRAM_FAS_LC3_FASLG_STAT3 |
DRAM_FAS_LC3_CDH1_FASLG | ATG7_DRAM_FAS_LC3_MMP9_FASLG |
PTEN_CDH1_ID2_MMP9_TCF3 | LC3_CDH1_ID2_MMP9_TCF3_FASLG |
七种的组合 | 八种的组合 |
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 | ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 | ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 |
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 | ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 | ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 |
ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 | ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3 |
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 | ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 | ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 | ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 |
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 | BNIP3_DRAM_FAS_LC3_ID2MMP9_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 | ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG | ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 | ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 | ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG | ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 | BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG |
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 |
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 | ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 |
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 | ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 |
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG |
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 | ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 |
ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3 |
ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 | BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3 |
ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG | ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2 |
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 | ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3 |
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 | BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3 |
BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 | ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG |
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 | ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 |
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 | ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 |
ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 | AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG | BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 |
ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 | BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 |
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 | BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 |
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 | ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG | ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3 |
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1 |
BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 | ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 | ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2 |
ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG | ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 | ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG |
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 | BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3 |
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 | BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN3 |
BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 | BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 |
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 | ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG |
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 | ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 |
ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_FASLG |
BNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG | BNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3 |
ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 | ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3 |
BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 |
BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 | ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 |
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 | ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 | BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG |
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 | ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1 |
FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG | ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG |
优选的是,所述组合物或试剂盒用于预测C组的存活预后,并且所述基因是选自下表14所示的基因或基因的组中的一种或多种。
[表14]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
CSE1L | ID2_CIAP2 | ID2_CIAP2_SESN2 | AIFM1_ID2_CIAP2_SESN2 |
CIAP2 | CASP3_CIAP2 | ID2_CASP3_CIAP2 | PTEN_ID2_CIAP2_SESN2 |
TCF3 | ID2_TCF3 | ULK1_ID2_HMGB2 | DIABLO_ID2_CASP3_CIAP2 |
CDH2 | DIABLO_CDH2 | ULK1_ID2_HMGB1 | DRAM_FRAP1_CIAP2_TP63 |
FASLG | CSE1L_CDH2 | DIABLO_ID2_CASP3 | BAX_ID2_CIAP2_SESN2 |
BECN1 | CSE1L_TCF3 | ULK1_ID2_AGER | ID2_CIAP2_SESN2_VEGF |
CASP3 | CSE1L_CASP3 | ID2_CIAP2_RPS19BP1 | DRAM_ID2_CIAP2_SESN2 |
CDH1 | CSE1L_RPS19BP1 | CASP8_ULK1_ID2 | ID2_CIAP2_RPS19BP1_SESN2 |
CDH2_CIAP2 | ID2_TCF3_CIAP2 | CBS_ID2_CIAP2_SESN2 | |
ULK1_ID2 | FRAP1_ID2_CIAP2 | ATG3_ID2_CIAP2_SESN2 | |
CSE1L_ID2 | AIFM1_CDH1_CIAP2 | NNMT_ID2_CIAP2_SESN2 | |
CDH1_CIAP2 | PTEN_CDH1_CIAP2 | DIABLO_ID2_CIAP2_SESN2 | |
CSE1L_FASLG | ULK1_ID2_CIAP2 | PRKAA1_ID2_CIAP2_SESN2 | |
NNMT_CIAP2 | DIABLO_ID2_CDH2 | FRAP1_ID2_CIAP2_SESN2 | |
CSE1L_MMP9 | CDH1_CIAP2_VEGF | DIABLO_DRAM_ID2_CASP3 | |
CSE1L_CDH1 | CDH1_CCNG2_CIAP2 | XIAP_ID2_CIAP2_SESN2 | |
CIAP2_RPS19BP1 | BAX_CDH1_CIAP2 | ID2_CIAP2_RAGE_SESN2 | |
ID2_CDH2 | ATG3_ID2_TCF3 | DRAM_CIAP2_SESN2_TP63 | |
CDH2_RPS19BP1 | ULK1_ID2_MMP2 | BNIP3_ID2_CIAP2_SESN2 | |
CSE1L_STAT3 | CBS_ULK1_ID2 | BCL2L1_ID2_CIAP2_SESN2 | |
DIABLO_CASP3 | DIABLO_ID2_CIAP2 | AIFM1_DIABLO_CDH1_CIAP2 | |
CDH1_TCF3 | LC3_ID2_CIAP2 | ID2_CCNG2_CIAP2_SESN2 | |
CSE1L_SIRT1 | PTEN_ULK1_ID2 | LC3_ID2_CIAP2_SESN2 | |
CIAP2_SESN2 | BAX_ULK1_ID2 | ID2_CASP3_CIAP2_RPS19BP1 | |
AIFM1_CIAP2 | DIABLO_PTEN_CDH1 | AIFM1_CDH1_CIAP2_SESN2 | |
DIABLO_KIAA1967 | CDH1_CASP3_CIAP2 | ATG3_ID2_TCF3_RPS19BP1 | |
CSE1L_KIAA1967 | ULK1_ID2_CDH2 | DIABLO_FRAP1_ID2_CDH2 | |
AKT1_CSE1L | CDH1_CIAP2_RAGE | E2F1_ID2_CIAP2_SESN2 | |
CSE1L_SESN2 | ID2_CDH2_CIAP2 | ID2_CASP3_CIAP2_SESN2 | |
FRAP1_CDH2 | NNMT_ID2_CIAP2 | DRAM_ID2_CIAP2_RPS19BP1 | |
FRAP1_CIAP2 | XIAP_CIAP2_SESN2 | ID2_CIAP2_HMGB1_SESN2 | |
TCF3_FASLG | CSE1L_ID2_CASP3 | PTEN_ID2_CASP3_CIAP2 | |
FASLG_SESN2 | CSE1L_FRAP1_CDH2 | ATG3_ID2_MMP9_TCF3 | |
CSE1L_DIABLO | BCL2_ID2_SESN2 | LAMP1_ID2_CIAP2_SESN2 | |
CSE1L_SATB1 | AIFM1_ULK1_ID2 | AIFM1_ID2_CASP3_CIAP2 | |
MMP9_TCF3 | ULK1_ID2_RAGE | ATG5_ID2_CIAP2_SESN2 | |
ATG12_CSE1L | DIABLO_CDH1_CCNG2 | DIABLO_PTEN_CDH1_CIAP2 | |
ATG7_CSE1L | BAX_DIABLO_CDH1 | LAMP1_ID2_CASP3_CIAP2 | |
CSE1L_BECN1 | CSE1L_ID2_CDH2 | ID2_CIAP2_HMGB2_SESN2 | |
XIAP_CIAP2 | AIFM1_CIAP2_SESN2 | BCL2L1_CSE1L_ID2_SESN2 | |
CSE1L_FAS | NNMT_CDH1_CIAP2 | TKT_ID2_CIAP2_SESN2 | |
TCF3_RPS19BP1 | CBS_ID2_CIAP2 | DIABLO_XIAP_ID2_SESN2 | |
XIAP_SESN2 | DIABLO_CDH1_VEGF | FRAP1_LC3_ID2_CIAP2 | |
CIAP2_KIAA1967 | ID2_MMP9_TCF3 | ATG7_ID2_CIAP2_SESN2 | |
TKT_CIAP2 | AIFM1_DIABLO_CDH1 | ID2_AGER_CIAP2_SESN2 | |
PRKAA1_CIAP2 | PRKAA1_CIAP2_SESN2 | CSE1L_ID2_CASP3_CIAP2 | |
CDH2_FASLG | CDH1_ID2_CIAP2 | DRAM_CASP3_CIAP2_TP63 | |
CSE1L_FRAP1 | CSE1L_CASP3_CIAP2 | PTEN_CDH1_ID2_CIAP2 | |
CSE1L_CIAP2 | ULK1_ID2_VEGF | CDH1_ID2_CIAP2_RPS19BP1 | |
CSE1L_ULK1 | ID2_CIAP2_HMGB1 | ATG3_ULK1_ID2_HMGB1 | |
PTEN_CIAP2 | BCL2L1_CDH1_CIAP2 | FRAP1_ID2_CIAP2_RPS19BP1 | |
BCL2L1_CIAP2 | ID2_CIAP2_MMP2 | DIABLO_PTEN_ID2_CASP3 | |
CIAP2_VEGF | CSE1L_ID2_CIAP2 | ID2_CIAP2_SESN2_TP63 | |
ATG3_TCF3 | BCL2L1_CSE1L_CDH1 | ID2_TCF3_CIAP2_SESN2 | |
AKT1_TCF3 | CSE1L_CDH1_CASP3 | DIABLO_CDH1_CIAP2_VEGF | |
CSE1L_LC3 | CSE1L_XIAP_SESN2 | ATG3_ULK1_ID2_AGER | |
TKT_CDH2 | PRKAA1_CDH1_CIAP2 | ID2_CIAP2_MMP2_SESN2 | |
CDH1_ID2_MMP9_TCF3 |
五种的组合 | 六种的组合 |
DRAM_ID2_CIAP2_SESN2_TP63 | ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 |
AIFM1_DRAM_CIAP2_SESN2_TP63 | AIFM1_DRAM_TKT_CIAP2_SESN2_TP63 |
DRAM_FRAP1_CDH1_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63 |
ATG12_DRAM_FRAP1_CIAP2_TP63 | AIFM1_DRAM_ID2_CIAP2_SESN2_TP63 |
DRAM_FRAP1_XIAP_CIAP2_TP63 | DRAM_TKT_ID2_CIAP2_SESN2_TP63 |
DRAM_TKT_CIAP2_SESN2_TP63 | AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63 |
AIFM1_CDH1_ID2_CIAP2_SESN2 | DRAM_FRAP1_TKT_CDH1_CIAP2_TP63 |
AIFM1_DRAM_FRAP1_CIAP2_TP63 | ATG3_DRAM_ID2_CIAP2_SESN2_TP63 |
DRAM_FRAP1_TKT_CIAP2_TP63 | DRAM_PTEN_ID2_CIAP2_SESN2_TP63 |
PTEN_CDH1_ID2_CIAP2_SESN2 | DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 |
BAX_CDH1_ID2_CIAP2_SESN2 | DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63 |
DRAM_FRAP1_ID2_CIAP2_TP63 | ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63 |
DRAM_TKT_CASP3_CIAP2_TP63 | ATG7_DRAM_ID2_CIAP2_SESN2_TP63 |
CDH1_ID2_CCNG2_CIAP2_SESN2 | AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63 |
AIFM1_PTEN_ID2_CIAP2_SESN2 | ATG5_DRAM_ID2_CIAP2_SESN2_TP63 |
DIABLO_FRAP1_CDH1_ID2_CIAP2 | AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2 |
AIFM1_CBS_ID2_CIAP2_SESN2 | AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63 |
AIFM1_LAMP1_ID2_CIAP2_SESN2 | BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 |
DRAM_ID2_CASP3_CIAP2_TP63 | DRAM_NNMT_ID2_CIAP2_SESN2_TP63 |
DIABLO_PTEN_CDH1_ID2_CIAP2 | CASP8_DRAM_ID2_CIAP2_SESN2_TP63 |
CDH1_ID2_CIAP2_SESN2_VEGF | DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63 |
DIABLO_CDH1_ID2_CASP3_CIAP2 | DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63 |
AIFM1_ATG3_ID2_CIAP2_SESN2 | DRAM_LAMP1_ID2_CIAP2_SESN2_TP63 |
AIFM1_BNIP3_ID2_CIAP2_SESN2 | DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 |
AIFM1_DIABLO_CDH1_ID2_CIAP2 | BNIP3_DRAM_ID2_CIAP2_SESN2_TP63 |
ATG3_DRAM_ID2_CIAP2_SESN2 | DRAM_ID2_MMP9_CIAP2_SESN2_TP63 |
AIFM1_BAX_ID2_CIAP2_SESN2 | AKT1_DRAM_ID2_CIAP2_SESN2_TP63 |
DRAM_E2F1_CASP3_CIAP2_TP63 | DRAM_ID2_CIAP2_RAGE_SESN2_TP63 |
AIFM1_ID2_CIAP2_HMGB2_SESN2 | ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63 |
AIFM1_ID2_MMP9_CIAP2_SESN2 | DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63 |
DIABLO_CDH1_ID2_CIAP2_VEGF | DRAM_XIAP_ID2_CIAP2_SESN2_TP63 |
DIABLO_DRAM_XIAP_ID2_SESN2 | AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63 |
AIFM1_ATG5_ID2_CIAP2_SESN2 | ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63 |
AIFM1_ID2_CIAP2_HMGB1_SESN2 | CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63 |
BAX_DIABLO_CDH1_ID2_CIAP2 | AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63 |
DRAM_FRAP1_NNMT_CIAP2_TP63 | AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63 |
FRAP1_CDH1_ID2_CIAP2_RPS19BP1 | BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 |
DRAM_XIAP_CIAP2_SESN2_TP63 | CBS_DRAM_ID2_CIAP2_SESN2_TP63 |
AIFM1_DIABLO_ID2_CIAP2_SESN2 | DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 |
AIFM1_DRAM_ID2_CIAP2_SESN2 | AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63 |
AIFM1_ID2_CIAP2_SESN2_VEGF | DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63 |
AIFM1_TKT_ID2_CIAP2_SESN2 | DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2 |
ATG3_ID2_MMP9_TCF3_RPS19BP1 | DRAM_ID2_CIAP2_SESN2_TP63_VEGF |
ATG5_DRAM_CIAP2_SESN2_TP63 | AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63 |
CBS_FRAP1_ID2_CIAP2_SESN2 | BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63 |
AIFM1_DIABLO_ID2_CASP3_CIAP2 | AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63 |
AIFM1_NNMT_ID2_CIAP2_SESN2 | AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63 |
ATG3_DRAM_CIAP2_SESN2_TP63 | AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63 |
ATG3_FRAP1_ID2_CIAP2_SESN2 | AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63 |
BAX_DIABLO_DRAM_ID2_CASP3 | AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63 |
LAMP1_PTEN_ID2_CIAP2_SESN2 | AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63 |
CDH1_ID2_CIAP2_RAGE_SESN2 | AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63 |
CBS_DIABLO_ID2_CIAP2_SESN2 | DRAM_FRAP1_CDH1_CIAP2_TP63_VEGF |
DIABLO_CDH1_ID2_CCNG2_CIAP2 | AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63 |
DIABLO_LAMP1_ID2_CASP3_CIAP2 | DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2 |
AIFM1_DRAM_CASP3_CIAP2_TP63 | DRAM_TKT_XIAP_CIAP2_SESN2_TP63 |
BCL2L1_DRAM_FRAP1_CIAP2_TP63 | AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63 |
CDH1_ID2_MMP9_TCF3_CIAP2 | BAX_CDH1_ID2_MMP9_TCF3_CIAP2 |
七种的组合 | 八种的组合 |
AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 |
ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF |
ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 | ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63 |
ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF | AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 |
ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 |
ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 | AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 | ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 | AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 |
ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63 |
AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 | ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63 |
AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 | ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 |
AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 | ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF |
AIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 | ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63 |
AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 | AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 |
ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 | ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 |
AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 | ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63 |
ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 | ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 | ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63 |
AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 | AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 |
AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 | AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63 |
AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 | ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 | ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGF |
AIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 | AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 |
AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 | AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 |
AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 | ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 |
AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 | ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGF |
DRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 | ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63 |
AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 | ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 |
AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 | AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 |
AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 | AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 |
AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 | ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 |
ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 | ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 |
AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 | ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63 |
AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF | ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63 |
AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 | ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 |
AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 | ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 |
AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 | ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF |
DRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 | AIFM1_ATG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 |
BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 | AIFM1_DRAM_NNMT_PTEN_ID2_CIAP2_SESN2_TP63 |
AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 | ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 |
AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 | ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63 |
AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF | AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63 |
ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 | AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63 |
AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 | ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 |
AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 | ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 |
AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 | AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 |
AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 | AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 |
AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 | ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63 |
AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 | ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF |
AIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 | ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 |
AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 | ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 |
ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 | ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 |
BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 | ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63 |
BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 | ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63 |
CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 | ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER |
优选的是,所述组合物或试剂盒用于预测C组的无病存活预后,并且所述基因是选自下表15所示的基因或基因的组中的一种或多种。
[表15]
一种 | 两种的组合 | 三种的组合 | 四种的组合 |
FASLG | FAS_FASLG | FAS_LC3_FASLG | DIABLO_FAS_LC3_FASLG |
CIAP2 | LC3_FASLG | DIABLO_FAS_FASLG | FAS_LC3_FASLG_UVRAG |
FAS | E2F1_FASLG | E2F1_LC3_FASLG | E2F1_FAS_LC3_FASLG |
CSE1L | CIAP2_FASLG | FAS_FASLG_RPS19BP1 | BNIP3_FAS_LC3_FASLG |
TCF3 | DIABLO_FASLG | E2F1_FAS_FASLG | DRAM_FAS_LC3_FASLG |
FASLG_RPS19BP1 | FAS_FASLG_UVRAG | ATG7_FAS_LC3_FASLG | |
FASLG_SESN2 | DIABLO_LC3_FASLG | FAS_LAMP1_LC3_FASLG | |
CASP3_FASLG | ATG7_FAS_FASLG | FAS_FRAP1_LC3_FASLG | |
FASLG_UVRAG | FAS_FASLG_SESN2 | ATG3_FAS_LC3_FASLG | |
FRAP1_FASLG | LC3_FASLG_SESN2 | FAS_LC3_FASLG_RPS19BP1 | |
PTEN_FASLG | FAS_LAMP1_FASLG | FAS_LC3_FASLG_SESN3 | |
FASLG_HMGB1 | ATG3_FAS_FASLG | FAS_LC3_FASLG_SESN2 | |
ATG3_FAS | CIAP2_FASLG_SESN3 | ATG5_FAS_LC3_FASLG | |
CASP3_CIAP2 | FAS_FRAP1_FASLG | FAS_LC3_FASLG_STAT3 | |
TCF3_FASLG | FRAP1_LC3_FASLG | FAS_LC3_FASLG_SIRT1 | |
ATG7_FASLG | BNIP3_LC3_FASLG | AKT1_FAS_LC3_FASLG | |
PTEN_CIAP2 | FAS_FASLG_SESN3 | FAS_LC3_ID2_FASLG | |
CDH2_FASLG | BNIP3_FAS_FASLG | FAS_LC3_FASLG_NAMPT | |
FASLG_SESN3 | DIABLO_FASLG_SESN2 | FAS_LC3_BECN1_FASLG | |
DIABLO_FAS | CIAP2_FASLG_UVRAG | FAS_LC3_MMP9_FASLG | |
FAS_LC3 | LC3_FASLG_UVRAG | DIABLO_FAS_FASLG_UVRAG | |
ULK1_FASLG | LC3_CIAP2_FASLG | ATG12_FAS_LC3_FASLG | |
CSE1L_FASLG | DRAM_FAS_FASLG | FAS_FASLG_RPS19BP1_UVRAG | |
CBS_FASLG | LC3_FASLG_SESN3 | DIABLO_FAS_FASLG_SESN2 | |
FASLG_HMGB2 | FAS_FASLG_STAT3 | FAS_LC3_FASLG_LAMP2 | |
FAS_UVRAG | ATG7_LC3_FASLG | FAS_LC3_CDH1_FASLG | |
LAMP1_FASLG | ATG5_FAS_FASLG | DIABLO_FAS_FASLG_SESN3 | |
BNIP3_FASLG | E2F1_FASLG_SESN2 | FAS_LC3_TCF3_FASLG | |
MMP9_FASLG | LC3_ID2_FASLG | E2F1_LC3_ID2_FASLG | |
TKT_FASLG | DRAM_LC3_FASLG | FAS_LC3_BHLHE41_FASLG | |
FASLG_STAT3 | FAS_TCF3_FASLG | DIABLO_FAS_LAMP1_FASLG | |
AKT1_FASLG | AKT1_FAS_FASLG | DIABLO_DRAM_FAS_FASLG | |
FASLG_MMP2 | E2F1_ULK1_FASLG | FAS_FASLG_SESN2_UVRAG | |
DRAM_FASLG | E2F1_TCF3_FASLG | FAS_FASLG_RPS19BP1_SESN3 | |
FASLG_SIRT1 | LC3_FASLG_RPS19BP1 | DIABLO_FAS_FRAP1_FASLG | |
ATG12_FASLG | LC3_MMP9_FASLG | DIABLO_FAS_FASLG_STAT3 | |
CIAP2_RAGE | FAS_FASLG_SIRT1 | ATG7_DIABLO_FAS_FASLG | |
FAS_LAMP1 | FAS_ULK1_FASLG | CSE1L_FAS_LC3_FASLG | |
ATG5_FASLG | FAS_FASLG_NAMPT | E2F1_LC3_MMP9_FASLG | |
ATG3_FASLG | LC3_FASLG_SIRT1 | DRAM_FAS_FASLG_RPS19BP1 | |
E2F1_FAS | CASP3_CIAP2_FASLG | DIABLO_FAS_FASLG_RPS19BP1 | |
BECN1_FASLG | ATG12_FAS_FASLG | FAS_LC3_ULK1_FASLG | |
E2F1_CIAP2 | FAS_BECN1_FASLG | DIABLO_FAS_FASLG_SIRT1 | |
CASP8_FASLG | ATG5_LC3_FASLG | DIABLO_FAS_ID2_FASLG | |
XIAP_CIAP2 | LC3_BECN1_FASLG | AKT1_DIABLO_FAS_FASLG | |
CDH1_FASLG | LC3_FASLG_STAT3 | DIABLO_FAS_FASLG_NAMPT | |
FASLG_NAMPT | E2F1_FASLG_SESN3 | ATG3_FAS_FASLG_SESN2 | |
BNIP3_FAS | AKT1_LC3_FASLG | FAS_FASLG_RPS19BP1_SESN2 | |
FASLG_LAMP2 | FAS_FASLG_LAMP2 | DIABLO_FAS_BECN1_FASLG | |
AGER_FASLG | LC3_TCF3_FASLG | DIABLO_FAS_CDH1_FASLG | |
ID2_FASLG | LC3_FASLG_NAMPT | ATG7_FAS_FASLG_UVRAG | |
AIFM1_FASLG | LC3_CDH1_FASLG | DIABLO_FAS_FASLG_LAMP2 | |
FASLG_SESN1 | ATG12_LC3_FASLG | FAS_FRAP1_FASLG_RPS19BP1 | |
AIFM1_CIAP2 | PTEN_CDH1_CIAP2 | FAS_LAMP1_FASLG_UVRAG | |
PRKAA1_CIAP2 | LC3_FASLG_LAMP2 | E2F1_FAS_LAMP1_FASLG | |
BCL2L1_CIAP2 | DIABLO_FASLG_SESN3 | ATG7_FAS_FASLG_RPS19BP1 | |
XIAP_FASLG | FAS_CDH1_FASLG | E2F1_FAS_FASLG_UVRAG | |
CDH1_ID2_MMP9_TCF3 |
五种的组合 | 六种的组合 |
DIABLO_FAS_LC3_ID2_FASLG | BNIP3_DRAM_FAS_LC3_FASLG_SESN2 |
DRAM_FAS_LC3_FASLG_UVRAG | DIABLO_DRAM_FAS_LC3_ID2_FASLG |
DIABLO_DRAM_FAS_LC3_FASLG | ATG3_FAS_LC3_MMP9_FASLG_SESN2 |
BNIP3_FAS_LC3_FASLG_UVRAG | DRAM_FAS_LC3_ID2_FASLG_UVRAG |
BNIP3_FAS_LC3_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_FASLG_UVRAG |
BNIP3_DRAM_FAS_LC3_FASLG | BNIP3_FAS_LC3_FASLG_SESN2_UVRAG |
BNIP3_DIABLO_FAS_LC3_FASLG | DIABLO_FAS_LC3_ID2_FASLG_UVRAG |
FAS_LC3_ID2_FASLG_UVRAG | DIABLO_FAS_LC3_ID2_FASLG_STAT3 |
DIABLO_FAS_LC3_FASLG_UVRAG | DIABLO_FAS_LC3_ID2_FASLG_SESN3 |
DIABLO_FAS_LC3_FASLG_STAT3 | BNIP3_FAS_LC3_MMP9_FASLG_UVRAG |
DIABLO_FAS_LC3_FASLG_SESN3 | BNIP3_DRAM_FAS_LC3_FASLG_SESN3 |
DIABLO_FAS_LC3_FASLG_SIRT1 | BNIP3_FAS_LC3_ID2_FASLG_UVRAG |
FAS_LC3_MMP9_FASLG_RPS19BP1 | DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 |
ATG5_FAS_LC3_FASLG_UVRAG | BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1 |
BNIP3_FAS_LC3_FASLG_SESN3 | BNIP3_FAS_LC3_ID2_FASLG_SESN2 |
DIABLO_FAS_LC3_BECN1_FASLG | BNIP3_DIABLO_FAS_LC3_ID2_FASLG |
DIABLO_FAS_LC3_CDH1_FASLG | BNIP3_FAS_LC3_MMP9_FASLG_SESN2 |
ATG3_FAS_LC3_FASLG_SESN2 | DIABLO_FAS_LC3_ID2_FASLG_SIRT1 |
DRAM_E2F1_FAS_LC3_FASLG | ATG5_DRAM_FAS_LC3_FASLG_UVRAG |
FAS_LC3_FASLG_SESN2_UVRAG | FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG |
DIABLO_FAS_LC3_FASLG_LAMP2 | ATG3_FAS_LC3_FASLG_SESN2_SESN3 |
E2F1_FAS_LC3_ID2_FASLG | DRAM_FAS_LC3_FASLG_SESN2_UVRAG |
DIABLO_FAS_LC3_FASLG_NAMPT | DIABLO_FAS_LC3_ID2_BECN1_FASLG |
DIABLO_FAS_LC3_MMP9_FASLG | DRAM_FAS_LC3_FASLG_SIRT1_UVRAG |
FAS_LC3_FASLG_SIRT1_UVRAG | FAS_LC3_ID2_FASLG_SESN2_UVRAG |
FAS_LC3_FASLG_SESN3_UVRAG | DIABLO_FAS_LC3_CDH1_ID2_FASLG |
FAS_LAMP1_LC3_FASLG_UVRAG | FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 |
AKT1_DIABLO_FAS_LC3_FASLG | BNIP3_FAS_LC3_FASLG_SESN2_SESN3 |
DIABLO_FAS_FRAP1_LC3_FASLG | DIABLO_FAS_LC3_ID2_FASLG_NAMPT |
DIABLO_FAS_LC3_BHLHE41_FASLG | DIABLO_FAS_LC3_ID2_FASLG_SESN2 |
FAS_LC3_FASLG_STAT3_UVRAG | DIABLO_FAS_LC3_ID2_FASLG_LAMP2 |
DIABLO_FAS_LC3_FASLG_SESN2 | BNIP3_FAS_LC3_FASLG_SESN2_SIRT1 |
E2F1_FAS_LC3_MMP9_FASLG | BNIP3_FAS_LC3_FASLG_SESN2_STAT3 |
BNIP3_FAS_FRAP1_LC3_FASLG | DRAM_FAS_LC3_FASLG_SESN3_UVRAG |
DIABLO_FAS_LAMP1_LC3_FASLG | DIABLO_DRAM_FAS_LC3_FASLG_STAT3 |
FAS_LC3_BECN1_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_FASLG |
AKT1_FAS_LC3_FASLG_UVRAG | ATG5_FAS_LC3_ID2_FASLG_UVRAG |
BNIP3_FAS_LC3_MMP9_FASLG | BNIP3_FAS_LC3_FASLG_SESN3_UVRAG |
FAS_FRAP1_LC3_FASLG_UVRAG | DRAM_FAS_LC3_BECN1_FASLG_UVRAG |
BNIP3_FAS_LC3_FASLG_STAT3 | DIABLO_DRAM_FAS_LC3_CDH1_FASLG |
FAS_LC3_CDH1_FASLG_UVRAG | AKT1_DIABLO_FAS_LC3_ID2_FASLG |
FAS_LC3_FASLG_LAMP2_UVRAG | BNIP3_DIABLO_FAS_LC3_MMP9_FASLG |
FAS_LC3_MMP9_FASLG_UVRAG | DRAM_FAS_LC3_CDH1_FASLG_UVRAG |
ATG7_FAS_LC3_FASLG_UVRAG | DIABLO_FAS_FRAP1_LC3_ID2_FASLG |
ATG7_DRAM_FAS_LC3_FASLG | BNIP3_DRAM_FAS_LC3_FASLG_STAT3 |
BNIP3_FAS_LC3_FASLG_SIRT1 | DIABLO_DRAM_FAS_LC3_FASLG_SESN3 |
DRAM_FAS_LAMP1_LC3_FASLG | BNIP3_DIABLO_DRAM_FAS_LC3_FASLG |
ATG7_BNIP3_FAS_LC3_FASLG | DIABLO_DRAM_FAS_LC3_FASLG_SIRT1 |
BNIP3_FAS_LAMP1_LC3_FASLG | BNIP3_DRAM_FAS_FRAP1_LC3_FASLG |
ATG3_FAS_LC3_MMP9_FASLG | DIABLO_DRAM_FAS_LC3_BECN1_FASLG |
ATG5_DIABLO_FAS_LC3_FASLG | ATG3_FAS_LC3_MMP9_FASLG_SESN3 |
BNIP3_FAS_LC3_ID2_FASLG | DIABLO_FAS_LAMP1_LC3_ID2_FASLG |
ATG12_DIABLO_FAS_LC3_FASLG | DRAM_FAS_LC3_FASLG_LAMP2_UVRAG |
E2F1_FAS_LC3_FASLG_SESN3 | ATG5_FAS_LC3_FASLG_SESN2_UVRAG |
AKT1_BNIP3_FAS_LC3_FASLG | FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 |
FAS_LC3_FASLG_NAMPT_UVRAG | FAS_LAMP1_LC3_ID2_FASLG_UVRAG |
ATG12_FAS_LC3_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_ID2_FASLG |
PTEN_CDH1_ID2_MMP9_TCF3 | LC3_CDH1_ID2_MMP9_TCF3_FASLG |
七种的组合 | 八种的组合 |
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 | ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG |
BNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG | ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 | BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 | ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 |
ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG | BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 |
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG |
FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG | BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG | ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG |
DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG | DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG |
DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 | ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG |
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 | BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 | ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 | BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG | ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG |
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 | ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 |
BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG | ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1 |
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 | BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAG |
DIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 | DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 |
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 | ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3 |
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 | BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 |
BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 | ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG |
ATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG | ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 | ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3 |
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 | ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2 |
ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG | BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG |
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 | ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG |
DIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 |
DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 |
DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 | ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 | BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 |
FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 | ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG | BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAG |
DIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG | ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG |
DRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG | BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAG |
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 | ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 | BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAG |
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 | ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3 |
BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 | BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2 |
DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 | BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAG |
BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 | AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 |
ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG | BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2 |
DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG | ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAG |
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 | BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAG |
ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 | BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAG |
AKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 | BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG |
DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 | BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAG |
ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 | AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 |
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 | ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 |
BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 | ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG |
DRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG | ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 |
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG | BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2 |
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 | ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2 |
DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG | BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 |
E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG | FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG |
本发明的组合物或试剂盒中包含的核酸可以是引物或探针。
这些核酸可以具有诸如DNA和/或RNA等基因的互补序列,或者可以是杂交的。“引物”是指具有游离3′羟基的核酸序列,其能够与模板互补结合,并且使逆转录酶或DNA聚合酶能够引发模板的复制。引物是序列与特定基因的核酸序列互补的核苷酸,可以使用长度为约7bp~50bp、优选为约10bp~30bp的引物。引物可以包含不改变该引物的在DNA合成酶起始点发挥作用的基本特征的其他碱基序列。引物可以使用公知方法以化学手段合成,核酸序列可以使用相关领域中的多种公知手段来转化。
“探针”是指与靶核酸部分互补或完全互补的核酸链,和指能够用碱基特异性方法与靶核酸结合的寡核苷酸。优选的是,探针为与靶核酸完全互补的寡核苷酸。探针不仅包括核酸,而且还包括能够进行互补结合的任何已知的核酸衍生物(包括肽核酸)。探针与靶核酸的结合(通常称之为“杂交”)是序列依赖性的,并且可以在多种条件下进行。通常,杂交反应在特定的离子水平和pH水平下在比特定序列的Tm低约5℃的温度进行。“Tm”是指下述条件:与靶标序列互补的探针已有50%结合到了该序列上。杂交反应条件的实例可以是pH为7.0~8.3且Na+离子浓度为0.01M~1.0M。此外,为了提高靶核酸和探针之间的特异性,该反应可以在不会使靶核酸与探针之间的结合变得不稳定的条件下进行,例如,在温度不高且不存在高浓度的去稳定剂(例如,甲酰胺等)的条件下进行。探针的长度可以是使得探针能够特异性地结合靶核酸的长度,其包括任何长度的多核苷酸。例如,探针的长度可以是10~200个核苷酸、10~150个核苷酸、10~100个核苷酸、10~50个核苷酸或整个基因的长度,但并不限于此。可以用可检测标记来标记探针。可检测标记可以在SYBR Green I或各种探针(TaqMan探针)的5′末端标记有荧光物质FAM,并且在其3′末端标记有淬灭剂TAMRA,但并不限于此。可检测标记包括荧光标记(例如Cy3或Cy5)、放射性物质标记、将底物转化为显色物的酶等,但并不限于此。在本发明的试剂盒中,探针或探针组可以固定在微阵列上。
使样品中的靶核酸与微阵列中的探针杂交,并且可以通过测量杂交结果来测定靶核酸的存在和浓度。可以用可检测标记来标记杂交过程中的靶核酸。
“抗体”是指能够特异性地结合抗原表位的蛋白,该概念包括多克隆抗体、单克隆抗体和重组抗体。抗体可以使用本领域中熟知的技术来容易地制造。具体而言,多克隆抗体可以使用本领域中熟知的下述方法来制造:将由本发明的肝癌预后标志物编码的蛋白抗原注射到动物体内并收集该动物的血液,从而获得包含抗体的血清。这些多克隆抗体可以从多种动物物种宿主制备,例如山羊、兔、绵羊、马、猪、牛和犬等。
单克隆抗体可以使用本领域中熟知的杂交瘤法[Kohler和Milstein(1976)European Journal of Immunology6:511-519]或噬菌体抗体文库技术[Clackson等,Nature,352:624-628,1991;Marks等,J.Mol.Biol.,222:58,1-597,1991]等来制备。
通常,杂交瘤法使用从已经注射了本发明第一方面的肝癌预后标志物所编码的蛋白抗原的免疫学适用宿主动物(例如小鼠)获得的细胞,并使用癌细胞系或骨髓瘤细胞系作为另一群体。使用本领域熟知的方法(例如聚乙二醇)使从这两个群体获得的组织融合,随后使用标准组织培养法使产生抗体的细胞进行增殖。按照有限稀释技术通过亚克隆来获得同源细胞群,随后按照已知的技术在体内或体外大量培养能够产生所需抗体的杂交瘤。噬菌体抗体文库方法是通过下述方式产生单克隆抗体的方法:获得所需抗体的基因,在噬菌体表面将该基因表达为融合蛋白形式,由此在体外产生抗体文库,并将所需的单克隆抗体从该文库中分离出。用上述方法制得的单克隆抗体可以使用已知的方法来分离,例如凝胶电泳、透析、盐析、离子交换色谱和亲和色谱等。
除了由两条全长轻链和两条全长重链组成的完整形状外,抗体还包括抗体分子的功能片段。抗体分子的功能片段是指具有抗原结合功能的片段,包括Fab、F(ab′)、F(ab′)2和Fv等。
对肝癌预后的预测可以是在进行癌症肝脏切除术之前或之后的预后预测。
除了核酸或抗体外,所述试剂盒还可以包含适用于分析基因的表达水平或表达模式的方法或适用于分析蛋白的存在水平或存在模式的方法的一种或多种其他成分、溶液或器件。例如,对于用于检测基因的表达水平或表达模式的诊断试剂盒,该诊断试剂盒可以包含进行RT-PCR所要求的必需成分,而且,根据具体实施方式,除了对标志基因有特异性的各引物之外,该RT-PCR试剂盒可以包含例如试管或其他适当的容器、反应缓冲溶液、脱氧核苷酸(dNTP)、酶(例如Taq聚合酶与逆转录酶)、DNA酶、RNA酶抑制剂、DEPC-水(DEPC水)、无菌水、作为定量对照组使用的基因特异性引物对。同时,对于用于检测蛋白的存在水平或存在模式的试剂盒,该诊断试剂盒可以包含例如进行ELISA所要求的必需成分。该ELISA试剂盒可以包含能够检测到所结合的抗体(例如,带标记的二抗)、生色团、酶(例如,连接在抗体上的酶)及其底物以及对定量对照组的蛋白有特异性的抗体的成分。此外,根据具体实施方式,该试剂盒还可以包含DNA微阵列或蛋白微阵列。
另外,本发明提供一种用于预测肝癌预后的组合物或试剂盒,所述组合物或试剂盒包含:对选自表2所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述),或对所述基因编码的蛋白有特异性的抗体。
在该组合物或试剂盒中,基因的组还可包含表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。
除非存在矛盾,针对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒而提及的内容也等同地适用于上述组合物和试剂盒。
此外,本发明提供一种根据分期来预测肝癌预后的方法,所述方法包括:(A)检测获自肝癌患者的样品中的选自由表1所示的基因组成的组的一种或至少两种基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)的表达水平或表达模式中的一项或多项;和(B)将步骤(A)的结果与对照组的测量结果进行比较,从而预测肝癌预后,其中,所述肝癌患者属于选自下述各组中的一个或多个组:A1组{门静脉侵袭阴性患者组,患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期,具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤},A2组{门静脉侵袭阴性患者组,患者具有尺寸大于5cm的肿瘤},B组{门静脉侵袭阴性患者组,患者处于BCLC分期系统中期,具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤},或C组{门静脉侵袭阳性患者组,不论肿瘤尺寸和数量如何}。
优选的是,上述由基因组成的组可以是由表2所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)组成的组,而且,上述由基因组成的组还可以包含表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。
采集自肝癌患者的样品是指从能够检测到肝癌预后标志物的表达水平或表达模式的人体中或从能够检测到肝癌预后标志物所编码的蛋白的存在水平或存在模式的人体中分离出的细胞和组织等。其实例可以是尿、血液、血浆和血清等,但并不特别限于此。所述组织可以包埋于石蜡块中。
所述基因的表达水平或表达模式可以用一般的生物化学分析方法来检测,这些方法用来确定由对应基因转录产生的mRNA的水平或模式。此类用于确定mRNA的水平或模式的分析方法有RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹和DNA微阵列等。此外,可以使用相关领域中通常使用的任何方法。
通过上述分析方法,肝癌患者的生物样品中的mRNA的水平或模式可以与标准水平进行比较,并可以从中检测出在肝癌预后标志物的表达水平和/或表达模式方面的差异。这使得能够对肝癌患者的预后进行预估。
用于通过RT-PCR来测量mRNA的水平或模式的试剂盒包含对本发明的肝癌预后标志物的mRNA有特异性的引物。根据具体实施方式,RT-PCR试剂盒可以包含试管或其他适当的容器、反应缓冲溶液、脱氧核苷酸(dNTP)、酶(例如Taq聚合酶和逆转录酶)、DNA酶、RNA酶抑制剂、DEPC-水和无菌水等。在适合的缓冲溶液和温度下,引物能够在聚合用试剂(即,DNA聚合酶或逆转录酶)和四种不同的三磷酸核苷的存在下引发DNA的合成。
使用抗体来测量蛋白的表达水平或表达模式的方法有蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS和蛋白芯片等。此外,可以使用相关领域中通常使用的任何方法。
通过上述分析方法,可以将受试肝癌患者的样品中的抗原-抗体复合物的形成水平和形成模式与标准水平进行比较,并可以从中确定出本发明的肝癌预后标志物所编码的蛋白的存在水平或存在模式,并最终能够预估出肝癌患者的预后。此处,“抗原-抗体复合物”是指肝癌预后标志物所编码的蛋白与其特异性抗体的复合物。抗原-抗体复合物的形成水平或形成模式通常可以通过检测与二抗联结的检测标记的信号的大小和模式来测量。此类检测标记的实例可以是酶、荧光物质、配体、发光物质、纳米颗粒、氧化还原分子和放射性同位素等,但并不限于此。当使用酶作为检测标记时,可以使用的酶有β-葡糖醛酸糖苷酶、β-D-葡萄糖苷酶、β-D-半乳糖苷酶、尿素酶、过氧化物酶或碱性磷酸酶、乙酰胆碱酯酶、葡萄糖氧化酶、己糖激酶和GDP酶、RNA酶、葡萄糖氧化酶、荧光素酶、磷酸果糖激酶、磷酸烯醇丙酮酸羧化酶、天冬氨酸氨基转移酶、磷酸烯醇丙酮酸脱羧酶和β-内酰胺酶等,但所述酶并不限于此。当使用荧光物质作为检测标记时,可以使用的荧光物质有荧光素、异硫氰酸酯、罗丹明、藻红蛋白、藻蓝蛋白、别藻蓝蛋白、邻苯二醛和荧光胺等,但所述荧光物质并不限于此。当使用配体作为检测标记时,可以使用的配体有生物素衍生物等,但所述配体并不限于此。当使用发光物质作为检测标记时,可以使用的发光物质有吖啶酯、荧光素和荧光素酶等,但所述发光物质并不限于此。当使用纳米颗粒作为检测标记时,可以使用的纳米颗粒有胶体金和彩色乳胶等,但所述纳米颗粒并不限于此。当使用氧化还原分子作为检测标记时,可以使用的氧化还原分子有二茂铁、钌络合物、紫罗碱、醌、Ti离子、Cs离子、二酰亚胺、1,4-苯醌、氢醌、K4W(CN)8、[Os(bpy)3] 2+、[Ru(bpy)3]2+和[Mo(CN)8]4-等,但所述氧化还原分子并不限于此。当使用放射性同位素作为检测标记时,可以使用的放射性同位素有3H、14C、32P、35S、36Cl、51Cr、57Co、58Co、59Fe、90Y、125I、131I或186Re等,但所述放射性同位素并不限于此。
“测量结果”是指步骤(A)中的从肝癌组织等收集的基因的表达水平或表达模式中的至少一项,“对照组的结果”可以指在通过对从肝癌预后已知的肝癌患者组(A1组、A2组、B组、C组)获得的测量值进行连续变量回归分析而获得的结果中具有最低p值的基因表达水平,或从表达水平获得的风险评分(参见N Engl J.Med2007;356:11-20)。测量结果或对照组的结果是用相同方法获得的表达水平或表达模式(高表达或低表达),并且可以根据不论患者是否患有肝癌都以恒定表达水平表达的对照基因(或基因的组)(B2M、GAPDH、HMBS、HPRT1和SDHA等)的平均表达水平来确定。
通过与从上述患者组获得的对照组的结果进行比较,来表征肝癌患者的测量结果,从而可以检测出其间的差异,并且可以使用任何可以检测出这种差异的物质来作为用于特异性地检测肝癌预后标志物的表达水平和/或表达模式的物质。对照组结果与测量结果之间的差异的检测结果能够为确定肝癌的治疗方法提供信息。
另外,本发明提供一种用于预测肝癌预后的方法,所述方法包括:(A)检测获自肝癌患者的样品中的选自由上表2所示的基因组成的组的一种或至少两种基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)的表达水平或表达模式中的一项或多项;和(B)将步骤(A)的结果与对照组的测量结果进行比较,从而预测肝癌预后。
上述由基因组成的组还可以包含上表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。
除非存在矛盾,针对本发明的用于根据肝癌分期来预测预后的肝癌预后预测方法而提及的内容也等同地适用于上述方法。
此外,除非存在矛盾,针对本发明的组合物或试剂盒而提及的内容也等同地适用于本发明的方法。
本发明的预测肝癌预后的方法可以是为预测肝癌预后提供信息的方法。
此外,本发明提供包含在本发明的组合物中的核酸或抗体在预测肝癌预后中的应用。
此外,本发明提供用于预测肝癌预后的核酸或抗体,且所述核酸或抗体是包含在本发明的组合物中的核酸或抗体。
除非存在矛盾,针对本发明的标志物、组合物或试剂盒、方法和用途而提及的内容都等同地适用。
发明效果
本发明的标志物、组合物或试剂盒以及方法使得可以有效地预测肝癌预后、优选根据分期来有效地预测肝癌预后。
附图说明
图1图示了BCLC分类表。
图2~图106是Kaplan-Meier曲线,其图示了通过在复发、存活和无病存活方面测量本发明的肝癌预后标志物而得到的数据。
具体实施方式
下文中,将借助于实施例来详细说明本发明;但描述这些实施例仅是为了帮助理解本发明,而不是以任何方式限制本发明的范围。
实施例1:预测肝癌预后
用下述方法发现了可用于预测肝癌预后的标志物,经确认,使用这些标志物可以预测肝癌预后。
1-1.RNA抽提和cDNA合成
从547位肝癌患者(已诊断出其出现肝癌,并确认了其肝癌的发展)中采集肝癌组织和附近的正常组织。这些肝癌患者是在诊断后经历了癌症肝脏切除术但没有接受其他治疗的患者,所述组织是在所述癌症肝脏切除术前采集并冷冻的组织。
抽提每份组织的RNA,并按照下述方法合成cDNA。
按照制造商的使用说明,使用RNeasy Minikit(Qiagen,德国)从肝癌组织和附近的正常组织中抽提出总RNA。使用Bioanalyzer2100(Agilent Technologies,美国)对所获得的RNA抽提物的总RNA进行称重。在抽提步骤中进行DNA酶I处理,以将污染了的基因组DNA从RNA抽提物中除去。将包含4μg总RNA的样品与2μl的10μM寡聚d(T)18引物(Genotech,韩国)在70℃温育7分钟,随后在冰上冷却5分钟。单独制备酶混合物[总体积11μl,制备方法为:添加2μl0.1M的DTT(Duchefa,荷兰)、2μl10×逆转录缓冲液、5μl2mM的dNTP、1μl200U/μl的MMLV逆转录酶和1μl40U/μl的RNA酶抑制剂(Enzynomics,韩国)]。将该酶混合物添加到包含RNA的样品中,之后将其在42℃温育90分钟,而后在80℃温育10分钟,从而使逆转录酶失活。添加用焦碳酸二乙酯(DEPC)处理过的水使上述样品的最终体积为400μl。
1-2:定量实时PCR
按照制造商的使用说明,在下表所示的基因标志物的存在下,使用PRISM7900HT(Applied Biosystems,美国)对从实施例1-1获得的每个cDNA样品进行实时PCR扩增。
该实时PCR分析在10μl的总体积中进行,其中包含5μl的2×Taqman基因表达主混合物(Applied Biosystems,美国)、5μM的正向引物和反向引物各1μl、1μl的1μM探针(Genotech,韩国)和2μl的cDNA(在对照组中为等量的水)。上述扩增以以下步骤组成的循环来进行:在95℃进行10分钟的解链步骤,之后是在95℃进行15秒的解链步骤,以及在60℃进行1分钟的合成步骤。使用Primer Express3.0(AppliedBiosystems,美国)来设计引物和探针的序列,并用FAM标记所有探针序列的5′末端,用TAMRA标记所有探针序列的3′末端。将下表16中的以下引物和探针序列用于每种标志物。
[表16]
基因 | 正向引物(SEQ ID NO.) | 反向引物(SEQ ID NO.) | 探针(SEQ ID No.) |
UVRAG | AATGTGCACCCTAGCCAAGAA(58) | TGCTCGCTGGGTAGGAGAGT(59) | AGAAGCCCTCTCCGGGCACCG(60) |
NAMPT | CGGCAGAAGCCGAGTTCA(61) | GCTTGTGTTGGGTGGATATTGTT(62) | CATCCTCCTGGCCACCGACTCCTAC(63) |
STAT3 | GCCAGAGAGCCAGGAGCAT(64) | GGTGTCACACAGATAAACTTGGTCTT(65) | AGCTGACCCAGGCGCTGCCC(66) |
CIAP2 | TGGTTTCCAAGGTGTGAGTACTTG(67) | GGGCTGTCTGATGTGGATAGC(68) | TCATCCGTCAAGTTCAAGCCAGTTACCCTC(69) |
BHLHE41 | CAAGCCTACCGTCCCACAGA(70) | CCAGTAACTGTCTCTCTTGCAAATG(71) | CCCAAAAATCGAAACAGAGGAAACGAACAG(72) |
MMP2 | GGTTGTCTGAAGTCACTGCACAGT(73) | CTCGGTAGGGACATGCTAAGTAGAG(74) | CATCTCAGCCCACATAGTGATGGTTCCC(75) |
SESN2 | TGCCTCCGGGACTGACA(76) | TGACCCTGACTTTCACATTGATG(77) | TGCCTTCTCTCCCCTGTCATTTCCAG(78) |
HMGB1 | CGGACAAGGCCCGTTATG(79) | AGAGGAAGAAGGCCGAAGGA(80) | AAAAGAAGTTCAAGGATCCCAATGCACCC(81) |
SIRT1 | AAAAACCTCCACGAACACAAAAA(82) | TGCTTGGTCTAAAAGTGTGACAATC(83) | TCAGAGTTGCCACCCACACCTCTTCA(84) |
RPS19BP1 | CGGAAGACGAAGGCAATTCA(85) | GCCGACTTGGGCACCTTT(86) | CCAGAAACTGCGGAACTCGGCCA(87) |
LAMP2 | GCCCCGCCCCTAGTCTTA(88) | ACCGACCACAGCCTTGCA(89) | CTCGCACTGAAGCGCCGATTCC(90) |
AGER | CCGAGTCCGTGTCTACCAGATT(91) | CACATGTCCCCACCTTATTGG(92) | TCTGCCTCTGAACTCACGGCTGGTGT(93) |
SESN3 | TCTGCCTGAACTGGTACATGCT(94) | TGGATTGATACCACTACCAAAAACA(95) | TGGTCCTCCTGGCACATTATCATGCTTT(96) |
ID2 | AACGACTGCTACTCCAAGCTCAA(97) | GGATTTCCATCTTGCTCACCTT(98) | TGCCCAGCATCCCCCAGAACAA(99) |
TCF3 | GCTGCCTTTGGTCTCTGGTTT(100) | AGAAATGCAATGCTCAGTCTAGGA(101) | AGTCCCGTGTCTCTCGCTATTTCTGCTG(102) |
HMGB2 | TGCCGGGAAGAGCACAA(103) | TCCATCTCTCCGAACACTTCTTG(104) | ACACCCGGACTCTTCCGTCAATTTCG(105) |
TP63 | GCTCCACCTTCGATGCTCTCT(106) | TGCTCGACTGCTGGAAGGA(107) | ATCACCCGCCATCCCCTCCAAC(108) |
RAGE | CCAATTTGTCCCCACAATGC(109) | GGGCGGCGATTCTCTCA(110) | CCTCCTGCACGCAATGGTGGC(111) |
KIAA1967 | CGTTGTTGCATGCTCTTTGTG(112) | CCAGCAAAAACTTAATCTGCTTCA(113) | CCAAGGGAGACGCCAGAGCATCC(114) |
SATB1 | GACCCGGCCACGAACA(115) | GTCGAGCTGGGCAGACAGA(116) | TTTCATACAAGACGTGGGCCTGTACCCTG(117) |
RAPTOR | GATGGCACTCAGCGAATGC(118) | ATGCGCACATCTCCATTGAC(119) | CTCCCTGCAGAAGCGTCCCGAC(120) |
SESN1 | TCCTGGGTGCATTCAGTCTCT(121) | GGAGCTGCACAGCCTTTAAAGT(122) | TGCCTCTGCCTGCCTCCTGGTC(123) |
CCNG2 | TCCCAGTATGATGGCCAGTCA(124) | ATAAGGCCAGCCAAAACTCAAG(125) | ATGCTGCTCTTCCCGTCCACAAGTG(126) |
CDH1 | AAATCTGAAAGCGGCTGATACTG(127) | CGGAACCGCTTCCTTCATAG(128) | CCCCACAGCCCCGCCTTATGA(129) |
FASLG | GAGATCCAGCTTGCCTCCTCTT(130) | CGGTTTTACTTCTTCTCAGTCCTGTA(131) | AGCAACAGGGTCCCGTCCTTGACA(132) |
CASP3 | CAGTGGAGGCCGACTTCTTG(133) | ATGAACCAGGAGCCATCCTTT(134) | TCCACAGCACCTGGTTATTATTCTTGGCG(135) |
BECN1 | GATGGTGTCTCTCGCAGATTCA(136) | TCAGATGCCTCCCCAATCAG(137) | ATGTCCACAGAAAGTGCCAACAGCTTCAC(138) |
CDH2 | GCACCCGCCTCAGTCAACT(139) | CAACATGGTACCGGCATGAA(140) | AATGAAAACCCTTATTTTGCCCCCAATCC(141) |
TWIST1 | TCCGCGTCCCACTAGCA(142) | AGTTATCCAGCTCCAGAGTCTCTAGAC(143) | CACCCCCTCAGCAGGGCCG(144) |
MMP9 | GGGCTCCCGTCCTGCTT(145) | ACTCCTCCCTTTCCTCCAGAAC(146) | TGCCATGTAAATCCCCACTGGGACC(147) |
VEGF | GCTTACTCTCACCTGCTTCTGAGTT(148) | TGGGCTGCTTCTTCCAACA(149) | AGACCACTGGCAGATGTCCCGGC(150) |
ATG12 | CGACAGCTTCGATTTGAATGAC(151) | GGGAGCGTCGCAAAGGA(152) | TGTAATTGCGTCCCCCTACTCCGGC(153) |
DIABLO | AATCACATTCAGCTGGTGAAACTG(154) | TGCCAGCTTGGTTTCTGCTT(155) | AAGAGGTGCACCAGCTCTCCCGG(156) |
E2F1 | CTGGACCACCTGATGAATATCTGT(157) | CAATGCTACGAAGGTCCTGACA(158) | CAGCTGCGCCTGCTCTCCGA(159) |
LAMP1 | TGCACTCAGATTTAAGCCTTACAAA(160) | TCACCACGAGTGACCTTCATG(161) | AAGCCTCTGGCCGTCACACGTAGG(162) |
LC3 | AACCAGCACAGCATGGTGAGT(163) | CCTCGTCTTTCTCCTGCTCGTA(164) | TCCACGCCCATCGCGGACA(165) |
ATG7 | CGGATGAATGAGCCTCCAA(166) | GGACATTATCAAACCGTGAAAGAA(167) | TCTTGGGCTTGTGCCTCACCAGATC(168) |
TKT | GAGGCTGTGTCCAGTGCAGTAG(169) | CCACTTCTTGGTACCCGGTTA(170) | CCTGGCATCACTGTCACCCACCTG(171) |
AIFM1 | TGAAGATCTCAATGAAGTAGCCAAACTAT(172) | CTGCAGTGGGTTTGCCAAT(173) | CAACATTCATGAAGACTGAAGCCCCACA(174) |
BNIP3 | TTCCCCCCAAGGAGTTCCT(175) | CGCTCGTGTTCCTCATGCT(176) | ACCCGAAGCGCACGGCCAC(177) |
ATG3 | CCATTGAAAATCACCCTCATCTG(178) | CACCTCAGCATGCCTGCAT(179) | CACCACCTCCCATGTGTTCAGTTCACC(180) |
DRAM | CAGCCGCCTTCATTATCTCCTA(181) | TGGAGGTGTTGTTCCCGTATC(182) | TGCTCTCCGGGCACGTCAACC(183) |
ATG5 | TTTCCTCCACTGCCATCATTAA(184) | GGCCAAAGGTTTCAGCTTCA(185) | CCTCAGCTGTGACATGAAAGACTTACCGG(186) |
NNMT | TTGAGGTGATCTCGCAAAGTTATT(187) | CTCGCCACCAGGGAGAAA(188) | CCACCATGGCCAACAACGAAGGAC(189) |
PRKAA1 | GGCAGTTGCCTACCATCTCATAA(190) | GCCGAGTCAGGTGATGATCA(191) | TCTATTTGGCGACAAGCCCACCTGATT(192) |
CASP8 | CCTTCTGATTGATGGTGCTATTTTG(193) | GCGGTGAGCCGAGATCAC(194) | CAGAATCTCGCTCTGTCGCCCAGG(195) |
ULK1 | TCGCGGCCGCATGT(196) | AAGGGTCCAGCACTATCAAGAGA(197) | AGCAGGTCCTGGGCGCCTCAAC(198) |
BCL2L1 | GATTGCCTTTGTTTTGATGTTTGT(199) | GGAAAGGGAACCCAGGTTAGTG(200) | CAGAATTGATCATTTTCCCCCCACTCTCC(201) |
FAS | AATGGTGTCAATGAAGCCAAAAT(202) | GTCATACGCTTCTTTCTTTCCATGA(203) | TGACAATGTCCAAGACACAGCAGAACAGAA(204) |
CSE1L | GCATGATCCTGTAGGTCAAATGG(205) | CAGGCGGTAGACAACTTGTGAA(206) | AATAACCCCAAAATTCACCTGGCACAGTCA(207) |
FRAP1 | AGGCCGCATTGTCTCTATCAA(208) | GCAGTAAATGCAGGTAGTCATCCA(209) | TGCAATCCAGCTGTTTGGCGCC(210) |
AKT1 | TCTCGGGTGCATTTGAGAGAA(211) | ACAGCACAAAAACGTCTTTCCA(212) | CCACGCTGTCCTCTCGAGCCCA(213) |
BAX | GGTTGTCGCCCTTTTCTACTTTG(214) | CAGTTCCGGCACCTTGGT(215) | CAGCAAACTGGTGCTCAAGGCCCT(216) |
BCL2 | CATGTGTGTGGAGAGCGTCAA(217) | GCCGGTTCAGGTACTCAGTCA(218) | CCTGGTGGACAACATCGCCCTGT(219) |
PTEN | TGGCGGAACTTGCAATCC(220) | GCTGAGGGAACTCAAAGTACATGA(221) | ATATTCCTCCAATTCAGGACCCACACGAC(222) |
CBS | GTTGGCAAAGTCATCTACAAGCA(223) | GGGCGAAGTGGTCCATCTC(224) | ACGCTGGGCAGGCTCTCGCAC(225) |
XIAP | GACAGGCCATCTGAGACACATG(226) | AGCATAGTCTGGCCAGTTCTGAA(227) | AGACACCATATACCCGAGGAACCCTGCC(228) |
每种标志基因的表达都平行测量3次,随后通过减去5种参照基因(B2M、GAPDH、HMBS、HPRT1和SDHA)的平均表达来进行标准化。将下表17中的引物和探针序列用于参照基因。
[表17]
测量每种标志物的CT(达到阈值所需的循环数),并计算ΔCT值(每种标志物的CT减去参照基因的平均CT)。mRNA的拷贝数以2-ΔCT计算。使用对cDNA样品的梯度稀释液进行同时扩增的结果构建了标准曲线。
从以上结果可以看出,利用包含在本发明的组合物中的核酸,可以测量标志物的表达水平和表达模式。此外,由于mRNA作为转录本被翻译成蛋白,还可以推知,利用包含在本发明的组合物中的抗体,还可以测量标志物的表达水平和表达模式。
1-3.统计学分析
考虑到从实施例1和2获得的每种标志物的标准化表达以及提供肝癌组织的患者的进展,完成了Kaplan-Meier曲线,并随后进行了显著性分析。
基于提供了肝癌组织的患者的进展,对于复发、存活和无病存活的各种情况,按时期升序排列了患者。通过用存活者(或复发的患者)的数量除以面临风险的患者数量,计算出了区间存活率(或区间复发率)。累积存活率(或累积复发率)为条件概率,其通过以下方法来计算:用之前的累积存活率(或累积复发率)乘以当前的区间存活率(或区间复发率)。Kaplan-Meier曲线被构建为阶跃函数,其中横轴为存活时间(或观察期),纵轴为累积存活率(或累积复发率)。
对于每种标志物,完成了对应于复发、存活和无病存活的Kaplan-Meier曲线。根据经实验确定的在统计学上具有显著性的参照值,将在实施例1和2中测得的每种标志物的表达分类为高表达和低表达,并使每种标志物的高表达情形和低表达情形彼此分开,从而完成Kaplan-Meier曲线。作为所述参照值,选择了在连续变量的回归分析结果中具有最低p值的基因表达值(见N Engl J Med2007;356:11-20)。将这些值用于Kaplan-Meier曲线以绘制成图(J.Amer.Statist.Assn.53:457481,1958)。用于确定Kaplan-Meier曲线中的显著性的标准是单基因或基因组合的p值是否低于0.05。
绘制Kaplan-Meier曲线是为了在547位分期尚未得到归类的肝癌患者中针对57种单基因、31种单基因和其中的至少两种的组合组成的基因的组来预测复发、存活和无病存活。将57种单基因的结果示于图2~22中。57种单基因的关于复发的Kaplan-Meier曲线示于图2~8中,57种单基因的关于存活的Kaplan-Meier曲线示于图9~15中,57种单基因的关于无病存活的Kaplan-Meier曲线示于图16~22中。
从这些图中可以确认,在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中,每种标志物都形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着,在每种标志物显示出高表达和低表达的情形之间,在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异,因此,每种标志物的表达模式都可以作为显示出患者的复发可能性或存活可能性的指数。
此外,显著性检验以下述方式进行:通过计算每个复发点或死亡点处的观察值和预期值,对每种标记物及其组合进行时序检验,从而获得χ2检验统计数字。其结果示于下表18~21中。57种标志物的结果示于表18中,单独使用或组合使用的31种标志物的结果示于表19~21中。其中,表19示出了31种标志物的复发预测结果,表20示出了31种标志物的存活预测结果,表21示出了31种标志物的无病存活预测结果。
[表18]
[表19]
[表20]
[表21]
在复发、存活和无病存活方面,每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言,在两种以上标志物组合的情况中,针对复发、存活和无病存活的所有p值都小于0.05,这是想要的结果。p值越低,统计学显著性就越高。因此,低p值意味着,利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
从以上结果可以发现,所组合的本发明的标记物越多,p值就越低。这意味着,所组合的本发明的标记物越多,所显示出的p值就越低,即显著性就越高,也就意味着,在基于这些标志物的组合对预后进行预估时所获得的准确性会提高更多。
此外可以发现,使用本发明的针对这些标志物的预测肝癌预后的方法,可以有效地预测A2组的肝癌预后。
另外,对31种基因进行了交叉验证。在该交叉验证中,将未根据分期分类的患者随机分为两组(阳性组:274位患者;测试组:273位患者)。在阳性组的认为具有统计学显著性的参照值固定的情况下,对于测试组,经计算,对复发、存活和无病存活的预估准确性在p<0.05或p<0.001的水平。
在所有未根据分期进行分类的患者中针对31种基因中的两种以上的组合对复发、存活和无病存活进行了预测,在对该预测的交叉验证结果中,在各方面都显示出优异的预后准确性的代表性实例如下:
复发:ATG3_FASLG_ID2_RPS19BP1_SESN3_TCF3(94%在p<0.05的水平)
存活:CSE1L_FAS_FRAP1_CDH1_BHLHE41_SESN2(95%在p<0.0001的水平)
无病存活:ATG12_FASLG_ID2_STAT3_RPS19BP1_TCF3(95.0%在p<0.05的水平)
实施例2:在A1组中预测肝癌预后
以与实施例1中相同的方式进行实验,不同之处在于:对经确定属于A1组(门静脉侵袭阴性患者组,BCLC(巴塞罗那临床肝癌)分期系统的0期或A期,具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤)的患者(277位患者)进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活,其结果示于图23~43中。针对复发的Kaplan-Meier曲线示于图23~29中,针对存活的Kaplan-Meier曲线示于图30~36中,针对无病存活的Kaplan-Meier曲线示于图37~43中。
从这些图中可以看出,在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中,上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着,在所述标志物为高表达和低表达的情形之间,在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异,因此,所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外,显著性检验以下述方式进行:通过计算每个复发点或死亡点处的观察值和预期值,对每种标记物及其组合进行时序检验,从而获得p值。其结果示于下表22~29中。仅使用一种标记物的结果示于表22中,两种标记物组合的结果示于表23中,三种标记物组合的结果示于表24中,四种标记物组合的结果示于表25中,五种标记物组合的结果示于表26中,六种标记物组合的结果示于表27中,七种标记物组合的结果示于表28中,八种标记物组合的结果示于表29中。
[表22]
[表23]
[表24]
[表25]
[表26]
[表27]
[表28]
[表29]
从以上表中可以确定,在复发、存活和无病存活方面,每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言,在两种以上标志物组合的情况中,针对复发、存活和无病存活的所有p值都较低。特别而言,发现了这种情况:单基因的p值相对高,但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低,统计学显著性就越高。因此,低p值意味着,利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着,所组合的本发明的标记物越多,所显示出的p值就越低,即显著性就越高,换言之,在基于这些标志物的组合对预后进行预估时,所获得的准确性会提高更多。
因此发现,表22~29中的标志物和/或标志物组合在预测A1组的肝癌预后(复发、存活和无病存活)时有效,利用针对这些标志物的核酸和抗体可以有效地预测A1组的肝癌预后。
还可以发现,使用本发明的针对这些标志物的预测肝癌预后的方法,可以有效地预测A1组的肝癌预后。
此外,对认为具有统计学显著性的标志物组合进行交叉验证。将每个患者组的患者随机分为两组(阳性组:139位患者;测试组:138位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下,对于测试组,经计算,对复发、存活和无病存活的预估准确性在p<0.05或p<0.001的水平。
在对A1组的复发、存活和无病存活的预测进行的交叉验证结果中,在各方面都显示出优异的预后准确性的代表性实例如下:
复发:ATG7_FRAP1_LC3_NNMT_STAT3(95%在p<0.05的水平)
存活:AKT1_CDH1_ID2(98.7%在p<0.05的水平)
无病存活:FRAP1_LC3_TKT_HMGB1_STAT3_TWIST1(84.0%在p<0.05的水平)
实施例3:在A2组中预测肝癌预后
以与实施例1中相同的方式进行实验,不同之处在于:对经确定属于A2组{门静脉侵袭阴性患者组,具有尺寸大于5cm的肿瘤}的患者(123位患者)进行实验,以与实施例1中相同的方式进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活,其结果示于图44~46中。针对复发的Kaplan-Meier曲线示于图44~50中,针对存活的Kaplan-Meier曲线示于图51~57中,针对无病存活的Kaplan-Meier曲线示于图58~64中。
从这些图中可以看出,在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中,上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着,在所述标志物为高表达和低表达的情形之间,在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异,因此,所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外,显著性检验以下述方式进行:通过计算每个复发点或死亡点处的观察值和预期值,对每种标记物及其组合进行时序检验,从而获得p值。其结果示于下表30~37中。仅使用一种标记物的结果示于表30中,两种标记物组合的结果示于表31中,三种标记物组合的结果示于表32中,四种标记物组合的结果示于表33中,五种标记物组合的结果示于表34中,六种标记物组合的结果示于表35中,七种标记物组合的结果示于表36中,八种标记物组合的结果示于表37中。
[表30]
[表31]
[表32]
[表33]
[表34]
[表35]
[表36]
[表37]
从以上表中可以确定,在复发、存活和无病存活方面,每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言,在两种以上标志物组合的情况中,针对复发、存活和无病存活的所有p值都较低。特别而言,发现了这种情况:单基因的p值相对高,但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低,统计学显著性就越高。因此,低p值意味着,利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着,所组合的本发明的标记物越多,所显示出的p值就越低,即显著性就越高,也就是说,在基于这些标志物的组合对预后进行估计时,所获得的准确性会提高更多。
因此发现,表30~37中的标志物和/或标志物组合在预测A2组的肝癌预后(复发、存活和无病存活)时有效,利用针对这些标志物的核酸和抗体可以有效地预测A2组的肝癌预后。
此外可以发现,使用本发明的针对这些标志物的预测肝癌预后的方法,可以有效地预测A2组的肝癌预后。
此外,对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组:62位患者;测试组:61位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下,对于测试组,经计算,对复发、存活和无病存活的预估准确性在p<0.05或p<0.001的水平。
在对A2组的复发、存活和无病存活的预测进行的交叉验证结果中,在各方面都显示出优异的预后准确性的代表性实例如下:
复发:TKT_SESN2_VEGF(65.0%在p<0.05的水平)
存活:DIABLO_FAS_LAMP1_BHLHE41_SESN2(83.3%在p<0.05的水平)
无病存活:TKT_SESN2_VEGF(82.0%在p<0.05的水平)
实施例4:在B组中预测肝癌预后
以与实施例1中相同的方式进行实验,不同之处在于:对经确定属于B组{门静脉侵袭阴性患者组,BCLC分期系统的中期,具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤}的患者(78位患者)进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活,其结果示于图65~85中。针对复发的Kaplan-Meier曲线示于图65~71中,针对存活的Kaplan-Meier曲线示于图72~78中,针对无病存活的Kaplan-Meier曲线示于图79~85中。
从这些图中可以看出,在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中,上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着,在所述标志物为高表达和低表达的情形之间,在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异,因此,所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外,显著性检验以下述方式进行:通过计算每个复发点或死亡点处的观察值和预期值,对每种标记物及其组合进行时序检验,从而获得p值。其结果示于下表38~45中。仅使用一种标记物的结果示于表38中,两种标记物组合的结果示于表39中,三种标记物组合的结果示于表40中,四种标记物组合的结果示于表41中,五种标记物组合的结果示于表42中,六种标记物组合的结果示于表43中,七种标记物组合的结果示于表44中,八种标记物组合的结果示于表45中。
[表38]
[表39]
[表40]
[表41]
[表42]
[表43]
[表44]
[表45]
从以上表中可以确定,在复发、存活和无病存活方面,每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言,在两种以上标志物组合的情况中,针对复发、存活和无病存活的所有p值都较低。特别而言,发现了这种情况:单基因的p值相对高,但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低,统计学显著性就越高。因此,低p值意味着,利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着,所组合的本发明的标记物越多,所显示出的p值就越低,即显著性就越高,换言之,在基于这些标志物的组合对预后进行预估时,所获得的准确性会提高更多。
因此发现,表38~45中的标志物和/或标志物组合在预测B组的肝癌预后(复发、存活和无病存活)时有效,利用针对这些标志物的核酸和抗体可以有效地预测B组的肝癌预后。此外可以发现,使用本发明的针对这些标志物的预测肝癌预后的方法,可以有效地预测B组的肝癌预后。
此外,对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组:39位患者;测试组:39位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下,对于测试组,经计算,对复发、存活和无病存活的预估准确性在p<0.05或p<0.001的水平。
在对B组的存活预测进行的交叉验证结果中,在各方面都显示出优异的预后准确性的代表性实例如下:
存活:DIABLO_BECN1_SIRT1(79.7%在p<0.05的水平)
实施例5:在C组中预测肝癌预后
以与实施例1中相同的方式进行实验,不同之处在于:对经确定属于C组{门静脉侵袭阳性患者组,不论肿瘤尺寸和数量如何}的患者(69位患者)进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活,其结果示于图86~106中。针对复发的Kaplan-Meier曲线示于图86~92中,针对存活的Kaplan-Meier曲线示于图93~99中,针对无病存活的Kaplan-Meier曲线示于图100~106中。
从这些图中可以看出,在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中,上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着,在所述标志物为高表达和低表达的情形之间,在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异,因此,所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外,显著性检验以下述方式进行:通过计算每个复发点或死亡点处的观察值和预期值,对每种标记物及其组合进行时序检验,从而获得p值。其结果示于下表46~53中。仅使用一种标记物的结果示于表46中,两种标记物组合的结果示于表47中,三种标记物组合的结果示于表48中,四种标记物组合的结果示于表49中,五种标记物组合的结果示于表50中,六种标记物组合的结果示于表51中,七种标记物组合的结果示于表52中,八种标记物组合的结果示于表53中。
[表46]
[表47]
[表48]
[表49]
[表50]
[表51]
[表52]
[表53]
以上各表呈现了每种基因及其组合的p值。
从以上表中可以确定,在复发、存活和无病存活方面,每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言,在两种以上标志物组合的情况中,针对复发、存活和无病存活的所有p值都较低。特别而言,发现了这种情况:单基因的p值相对高,但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低,统计学显著性就越高。因此,低p值意味着,利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着,所组合的本发明的标记物越多,所显示出的p值就越低,即显著性就越高,也就是说,在基于这些标志物的组合对预后进行估计时,所获得的准确性会提高更多。
因此发现,表41~48中的标志物和/或标志物组合在预测C组的肝癌预后(复发、存活和无病存活)时有效,利用针对这些标志物的核酸和抗体可以有效地预测C组的肝癌预后。此外可以发现,使用本发明的针对这些标志物的预测肝癌预后的方法,可以有效地预测C组的肝癌预后。
此外,对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组:35位患者;测试组:34位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下,对于测试组,经计算,对复发、存活和无病存活的预估准确性在p<0.05或p<0.001的水平。
在对C组的复发、存活和无病存活预测进行的交叉验证结果中,在各方面都显示出优异的预后准确性的代表性实例如下:
复发:FAS_TCF3_FASLG_RPS19BP1(69.0%在p<0.05的水平)
存活:CASP3_CDH2_CIAP2(77.0%在p<0.05的水平)
无病存活:FAS_TCF3_FASLG(75.0%在p<0.05的水平)
【工业应用性】
本发明提供用于预测肝癌预后的标志物、用于预测肝癌预后的组合物或试剂盒(优选为用于根据分期来预测肝癌的肝癌预后预测用组合物或试剂盒)以及用于预测肝癌预后的方法。本发明的标志物、组合物或试剂盒以及方法使得可以有效地预测肝癌预后、优选根据分期来有效地预测肝癌预后。
Claims (41)
1.一种用于预测肝癌预后的组合物或试剂盒,所述组合物或试剂盒包含:
对选自下表所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸,或对所述基因编码的蛋白有特异性的抗体;并且
所述组合物或试剂盒用于根据选自A1组、A2组、B组或C组的一个或多个组中的分期来预测肝癌预后;其中A1组为门静脉侵袭阴性患者组,患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期,具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤;A2组为门静脉侵袭阴性患者组,患者具有尺寸大于5cm的肿瘤;B组为门静脉侵袭阴性患者组,患者处于BCLC分期系统的中期,具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤;C组为门静脉侵袭阳性患者组,不论肿瘤尺寸和数量如何:
[表1]
4.如权利要求1所述的组合物或试剂盒,其中,所述预后是对复发、存活或无病存活的预测。
5.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测A1组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表4]
。
6.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测A1组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表5]
。
7.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测A1组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表6]
。
8.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测A2组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表7]
。
9.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测A2组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表8]
。
10.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测A2组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表9]
。
11.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测B组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表10]
。
12.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测B组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表11]
。
13.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测B组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表12]
。
14.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测C组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表13]
。
15.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测C组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表14]
16.如权利要求1所述的组合物或试剂盒,所述组合物或试剂盒用于预测C组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表15]
。
17.如权利要求1所述的组合物或试剂盒,其中,所述核酸是引物或探针。
18.如权利要求1所述的组合物或试剂盒,其中,所述肝癌预后是对癌症肝脏切除术后的预后的预测。
20.如权利要求19所述的组合物或试剂盒,其中,由基因组成的所述组还包含下表所示的基因:
[表3]
21.如权利要求19所述的组合物或试剂盒,其中,所述核酸是引物或探针。
22.如权利要求19所述的组合物或试剂盒,其中,所述预测肝癌预后是预测癌症肝脏切除术后的预后。
23.一种根据分期来预测肝癌预后的方法,所述方法包括:
(A)检测获自肝癌患者的样品中的选自由下表所示的基因组成的组的一种或至少两种基因的表达水平或表达模式中的一项或多项;和
(B)将步骤(A)的结果与对照组的测量结果进行比较,从而预测肝癌预后,
其中,所述肝癌患者属于选自A1组、A2组、B组或C组的一个或多个组;其中A1组为门静脉侵袭阴性患者组,患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期,具有1个尺寸为5cm以下的肿瘤或3个以下尺寸为3cm以下的肿瘤;A2组为门静脉侵袭阴性患者组,患者具有尺寸大于5cm的肿瘤;B组为门静脉侵袭阴性患者组,患者处于BCLC分期系统中期,具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤;C组为门静脉侵袭阳性患者组,不论肿瘤尺寸和数量如何;
[表1]
26.如权利要求23所述的方法,所述方法用于预测A1组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表4]
。
27.如权利要求23所述的方法,所述方法用于预测A1组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表5]
。
28.如权利要求23所述的方法,所述方法用于预测A1组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表6]
。
29.如权利要求23所述的方法,所述方法用于预测A2组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表7]
。
30.如权利要求23所述的方法,所述方法用于预测A2组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表8]
。
31.如权利要求23所述的方法,所述方法用于预测A2组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表9]
。
32.如权利要求23所述的方法,所述方法用于预测B组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表10]
。
33.如权利要求23所述的方法,所述方法用于预测B组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表11]
。
34.如权利要求23所述的方法,所述方法用于预测B组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表12]
。
35.如权利要求23所述的方法,所述方法用于预测C组的复发预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表13]
。
36.如权利要求23所述的方法,所述方法用于预测C组的存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表14]
。
37.如权利要求23所述的方法,所述方法用于预测C组的无病存活预后,其中,所述基因是选自下表所示的基因或基因的组中的一种或多种:
[表15]
。
38.如权利要求23~37中任一项所述的方法,其中,蛋白的表达水平或表达模式用选自以下方法中的一种或多种来检测:RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹、DNA微阵列、蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS或蛋白芯片。
39.一种预测肝癌预后的方法,所述方法包括:
(A)检测获自肝癌患者的样品中的选自由下表所示的基因组成的组的一种或至少两种基因的表达水平或表达模式中的一项或多项;和
(B)将步骤(A)的结果与对照组的测量结果进行比较,从而预测肝癌预后:
[表2]
41.如权利要求39或40所述的方法,其中,蛋白的表达水平或表达模式用选自以下方法中的一种或多种来检测:RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹、DNA微阵列、蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS或蛋白芯片。
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Application publication date: 20140205 |