CN103562404A - 预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法 - Google Patents

预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法 Download PDF

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CN103562404A
CN103562404A CN201080069658.8A CN201080069658A CN103562404A CN 103562404 A CN103562404 A CN 103562404A CN 201080069658 A CN201080069658 A CN 201080069658A CN 103562404 A CN103562404 A CN 103562404A
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朴真永
洪锡珠
金种旻
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Abstract

本发明提供用于获得肝癌预后的标志物、用于获得肝癌预后的组合物或试剂盒以及用于获得肝癌预后的方法，所述组合物或试剂盒优选是能够在各个分期获得肝癌预后的肝癌预后组合物或试剂盒。本发明的标志物、组合物或试剂盒以及方法能够有效地获得肝癌预后、优选在各个分期有效地获得肝癌预后。

Description

预测肝癌预后的组合物或试剂盒以及预测肝癌预后的方法
技术领域
本发明涉及一种用于预测肝癌预后的生物标志物。更具体而言，本发明涉及一种预测肝癌预后的组合物或试剂盒及预测肝癌预后的方法。
背景技术
肝癌已知是世界上最致命的癌症之一。特别而言，据报道，在亚洲和撒哈拉以南的非洲每年有至少约50万人死于肝癌。肝癌大体上可以分为源于肝细胞本身的肝细胞癌和从其他组织传播到肝脏的转移性肝癌。至少约90％的肝癌是肝细胞癌，通常将术语“肝癌”理解为肝细胞癌。
肝癌预后是指对肝癌患者的多种状况的预估，例如从肝癌完全恢复的可能性、治疗后复发的可能性、诊断患有肝癌后患者存活的可能性等。其视不同条件(例如疾病的严重程度、诊断点、治疗进程等)而有所不同。肝癌仅在根据其预后来正确地使用各种治疗方法时能够得到高效地治疗。例如，对于被评估为预后良好的患者，有必要避免使用可能为患者带来严重副作用的危险治疗方法(例如攻击性的化学治疗或手术、放射治疗)而选择相对温和、保守和安全的治疗方法。另一方面，对于被评估为预后不佳的患者，为了延长生存期或提高生存率，应当积极地进行化学治疗或手术、诸如放射治疗等治疗方法。
根据迄今为止已进行的研究可知，对于已发生进展的肝癌，其预后非常差，并且显示出自诊断起6个月内死亡、平均存活期仅为4个月的高致死率。但是，尺寸小于3cm的肝癌却具有良好的预后，已知其在不进行任何特殊治疗时及在术后的1年内的生存率为90％，5年内的生存率为约40％～50％。然而，用现有技术来精确地预估肝癌预后是非常困难的。为了准确地预估预后，必须有一种将患者分类为各个风险组的分析方法。然而，迄今为止，预后仅仅是根据诊断时的临床病理学肝癌分期以及初步的外科手术治疗来确定，并不存在准确地预估肝癌预后的手段。
常规的分析方法包括BCLC(巴塞罗那临床肝癌)分期系统。该系统是通过在对患者进行外科手术前确定患者的肝癌分期来将肝癌患者分类从而确定治疗方法(肝脏切除、肝脏移植或射频消蚀等，视疾病分期而定)的系统(Llovert JM，Bru C，Bruix J.Prognosis of hepatocellular carcinoma：the BCLC staging classification.Semin Liver Dis.1999；19(3)：329-338)。
然而，可惜的是，仅凭肝癌分期不能精确地确定每个肝癌患者的预后。因此，有必要开发一种使用基因标志物来对肝癌患者的预后进行精确预测的技术。即，基于每位个体患者的分期和预后结果来选择被预期为对特定治疗方法(例如，肝脏切除术)响应良好的患者，并向这些患者提供所述治疗，从而能够改进肝癌患者的整体治疗结果，并能够预期产生如节省医疗成本等社会经济效应。
同时，对于UVRAG、NAMPT、STAT3、CIAP2、BHLHE41、MMP2、SESN2、HMGB1、SIRT1、RPS19BP1、LAMP2、AGER、SESN3、ID2、TCF3、HMGB2、TP63、RAGE、KIAA1967、SATB1、RAPTOR、SESN1、CCNG2、CDH1、FASLG、CASP3、BECN1、CDH2、TWIST1、MMP9、VEGF、ATG12、DIABLO、E2F1、LAMP1、LC3、ATG7、TKT、AIFM1、BNIP3、ATG3、DRAM、ATG5、NNMT、PRKAA1、CASP8、ULK1、BCL2L1、FAS、CSE1L、FRAP1、AKT1、BAX、BCL2、PTEN、CBS、XIAP等蛋白，它们在肝癌组织中的表达水平或表达模式如何随肝癌的分期而变化，以及如何能够将它们用于根据分期来预测肝癌预后，都是已知的。虽然在一些情况下已使用上述蛋白或一些编码上述蛋白的基因来作为肝癌预后的标志物，但是尚无使用它们来作为根据分期来进行肝癌预后的标志物的情况。
在进行了有关预测肝癌预后的研究后，本发明人发现了表达水平和表达模式(根据肝癌的分期)发生显著变化的基因，并完成了本发明。
具体实施方式
技术主题
本发明所要解决的一个技术主题是提供一种用于预测肝癌预后的生物标志物，所述生物标志物能够(根据癌症的分期)对预后进行预测。
本发明所要解决的另一技术主题是提供一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒能够(根据癌症的分期)对预后进行预测。
本发明所要解决的又一个技术主题是提供一种用于预测肝癌预后的方法，所述方法可以用来(根据癌症的分期)对预后进行预测。
实现主题的方法
本发明提供一种用于预测肝癌预后的生物标志物，优选是用于根据分期来预测肝癌预后的生物标志物，所述生物标志物是选自下表1所列的基因和这些基因所编码的蛋白中的至少一种。
[表1]
Figure BDA00003059959300031
Figure BDA00003059959300041
在上表中，NCBI GI(Geninfo标识符)是指由美国国家生物技术信息中心(NCBI)提供的序列识别号，其由登录号和版本号组成。
在本发明中，“肝癌”包括源于肝细胞本身的肝细胞癌和从其他组织传播到肝脏的转移性肝癌。优选的是，“肝癌”指肝细胞癌。
在本发明中，“用于预测肝癌预后的标志物”是指基因标志物，其作为在肝癌出现后预测肝癌预后的标准。该标志物具有显著低的p值，其中所述p值根据所述标志物在具有不同预后的患者的肝癌细胞和/或组织中的表达差异计算得到。优选的是，所述标志物的p值小于0.05。
此外，本发明提供用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：对选自表1所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸，或对所述基因编码的蛋白有特异性的抗体；且所述组合物或试剂盒用于根据选自下述各组的一个或多个组中的分期来预测肝癌预后：A1组{门静脉侵袭阴性患者组，患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤}，A2组{门静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤}，B组{门静脉侵袭阴性患者组，患者处于BCLC分期系统的中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤}，或C组{门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何}。
所述至少两种基因可以是至少三种、四种、五种、六种、七种或八种以上基因。
优选的是，由基因组成的所述组可以是下表2所示的基因组成的组。
[表2]
Figure BDA00003059959300051
更优选的是，由基因组成的所述组还可以包含下表3所示的基因。
[表3]
Figure BDA00003059959300052
Figure BDA00003059959300061
在上表2所示的基因中，CDH1、ID2、MMP9、TCF3可以从表2中排除，并且可以进一步包含在表3所示的基因的组中。
BCLC分类(即，图1中所用的分类)是通过在对肝癌患者进行外科手术前确定肝癌的分期来将肝癌患者分类从而确定治疗方法(肝脏切除、肝脏移植或射频消蚀等，视分期而定)的系统(Llovert JM，Bru C，Bruix J.Prognosis of hepatocellular carcinoma：the BCLC staging classification.Semin Liver Dis.1999；19(3)：329-338)。在图1中，体力状态测试(PST)分为阶段0～阶段4。阶段0是指体力无问题的情况；阶段1是指患者能够进行轻度工作的情况；阶段2是指患者不能工作但可以照料自己的情况；阶段3是指患者能够有限地照料自己且日常生活的至少50％是在床上或椅上度过的阶段；阶段4是指患者不能进行任何活动、不能照料自己且全天都在床上或椅上度过的情况。在Okuda分期中，各期基于四种标准来确定，并根据癌的尺寸大于还是小于整个肝脏的50％、根据是否存在腹水并根据胆红素数值(小于或大于3mg/dL)和白蛋白数值(小于或大于3g/dL)来将这些期分类为I期、II期、III期。Child-Pugh分级是评估肝硬化患者的肝功的指数。评估了白蛋白值(＞3.5g/dL：1分；2.8～3.5g/dL：2分；＜2.8g/dL：3分)、胆红素值(＜2.0mg/dL：1分；2.0～3.0mg/dL：2分；＞3.0mg/dL：3分)、凝血酶原时间值(＞50％：1分；40％～50％：2分；＜40％：3分)、腹水的存在(无：1分；略有：2分；中等：3分)、脑病分级(无：1分；不确定的脾气变化、抑郁、震颤、嗜睡、讲话缓慢且口齿不清、扑翼样震颤、行走困难：2分；肌肉僵直、失定向、意识错乱、间歇性肌痛性痉挛、眼球震颤、昏迷、瞳孔散大、去大脑动物姿势：3分)等。6分以下为A类，7～9分为B类，10分以上为C类。
以上预后能够预示复发、存活或无病存活，并且可以作为进行了癌症肝脏切除术后的预后。“复发”指的是进行了癌症肝脏切除术后的存活者的肝癌复发。“存活”是指在癌症肝脏切除术后5年内的存活率。无病存活是指进行癌症肝脏切除术后无复发的存活。
优选的是，所述组合物或试剂盒用于预测A1组的复发预后，并且所述基因是选自下表4所示的基因或基因的组中的一种或多种。
[表4]
一种 两种的组合 三种的组合 四种的组合
BCL2L1 FRAP1_SESN1 FRAP1_CASP3_CDH2 ID2_NAMPT_RPS19BP1_SESN3
BECN1 FRAP1_TWIST1 ID2_CDH2_SESN3 FRAP1_LC3_CASP3_CDH2
BAX FRAP1_CASP3 FRAP1_CDH2_SESN1 FRAP1_TKT_CASP3_CDH2
CDH2 FRAP1_CCNG2 FRAP1_LC3_CASP3 BAX_FRAP1_LC3CDH2
NAMPT BAX_FRAP1 FRAP1_LC3_TWIST1 ID2_CDH2_NAMPT_SESN3
TWIST1 FRAP1_NNMT BAX_FRAP1_LC3 CBS_ID2_CDH2_SESN3
RPS19BP1 BCL2L1_FRAP1 FRAP1_CDH2_TWIST1 FRAP1_LC3_CDH2_KIAA1967
MMP2 AIFM1_FRAP1 FRAP1_NNMT_CDH2 FRAP1_CDH2_SESN1_STAT3
SESN3 FRAP1_RAGE FRAP1_LC3_NNMT FRAP1_LC3_NNMT_CDH2
ID2 FRAP1_VEGF BAX_FRAP1_CDH2 FRAP1_LC3_CDH2_RAPTOR
AGER ID2_CDH2 FRAP1_SESN1_STAT3 ID2_CDH2_RPS19BP1_SESN3
ATG12 FRAP1_PTEN AIFM1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
NAMPT_SESN3 FRAP1_LC3_VEGF FRAP1_LC3_CDH2_VEGF
BCL2_FRAP1 FRAP1_NNMT_MMP2 FRAP1_LC3_SESN1_STAT3
CDH2_SESN3 FRAP1_LC3_RAGE FRAP1_LC3_CDH2_RAGE
FRAP1_RAPTOR FRAP1_CCNG2_CDH2 FRAP1_LC3_NNMT_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 ID2_CDH2_MMP2_SESN3
FRAP1_XIAP FRAP1_CDH2_VEGF FRAP1_LC3_CASP3_STAT3
BECN1_SESN3 FRAP1_LC3_CCNG2 AIFM1_FRAP1_LC3_CDH2
HMGB1_TWIST1 FRAP1_CASP3_MMP2 BCL2L1_FRAP1_LC3_CDH2
ID2_NAMPT BCL2L1_FRAP1_LC3 FRAP1_LC3_PTEN_CDH2
FRAP1_PRKAA1 FRAP1_LC3_SESN1 BAX_FRAP1_LC3_BECN1
ID2_RPS19BP1 FRAP1_CDH2_KIAA1967 BAX_FRAP1_LC3_RPS19BP1
BAX_LC3 AIFM1_FRAP1_LC3 FRAP1_CASP3_CDH2_STAT3
FRAP1_TP63 FRAP1_LC3_RAPTOR LC3_HMGB1_STAT3_TWIST1
ATG12_SESN3 FRAP1_CDH2_RAGE BAX_FRAP1_TKT_CDH2
BAX_TWIST1 BAX_FRAP1_MMP2 FRAP1_LC3_CCNG2_CDH2
RPS19BP1_SESN3 FRAP1_LC3_PTEN FRAP1_TKT_CDH2_SESN1
BAX_MMP2 FRAP1_TKT_CASP3 FRAP1_LC3_HMGB1_TWIST1
SESN1_STAT3 FRAP1_PTEN_CDH2 FRAP1_NNMT_TKT_CDH2
LC3_TWIST1 FRAP1_TKT_TWIST1 BAX_FRAP1_LC3_MMP2
MMP2_NAMPT FRAP1_LC3_KIAA1967 FRAP1_LC3_CCNG2_STAT3
ID2_BECN1 BAX_FRAP1_TKT FRAP1_LC3_STAT3_TWIST1
BCL2L1_LC3 BCL2_FRAP1_CDH2 FRAP1_TKT_CDH2_TWIST1
MMP2_RPS19BP1 FRAP1_HMGB1_TWIST1 FRAP1_LC3_NNMT_MMP2
ATG7_BCL2L1 FRAP1_RPS19BP1_TWIST1 BAX_FRAP1_TKT_MMP2
ID2_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_NNMT_CDH2_MMP2
CDH2_HMGB1 FRAP1_TKT_SESN1 FRAP1_LC3_CDH2_SESN1
CDH2_MMP2 FRAP1_RPS19BP1_SESN1 BAX_FRAP1_LC3_TKT
ATG7_TWIST1 BAX_FRAP1_BECN1 FAS_FRAP1_CDH2_SESN1
BAX_SESN3 ID2_NAMPT_SESN3 BAX_FAS_FRAP1_LC3
FASLG_NAMPT FRAP1_CCNG2_STAT3 FRAP1_CASP3_CDH2_MMP2
ATG7_BAX BCL2L1_FRAP1_MMP2 ID2_FASLG_NAMPT_SESN3
TKT_NAMPT BCL2_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
STAT3_TWIST1 FASLG_NAMPT_SESN3 FRAP1_CDH2_HMGB1_TWIST1
BCL2L1_MMP2 AIFM1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_KIAA1967 FRAP1_CCNG2_RPS19BP1 DRAM_ID2_CDH2_SESN3
BAX_BECN1 BAX_FRAP1_RPS19BP1 FRAP1_LC3_RPS19BP1_TWIST1
ATG12_ID2 FAS_FRAP1_SESN1 AIFM1_FRAP1_TKT_CDH2
BECN1_MMP2 BCL2L1_FRAP1_TKT FRAP1_TKT_CCNG2_CDH2
AKT1_BAX FRAP1_NNMT_STAT3 BCL2L1_FRAP1_TKT_CDH2
LC3_RAPTOR FRAP1_MMP2_SESN1 DIABLO_ID2_CDH2_SESN3
BAX_RPS19BP1 FRAP1_ID2_TWIST1 BCL2_FRAP1_LC3_CDH2
BAX_TKT FRAP1_CASP3_STAT3 FRAP1_LC3_CASP3_FASLG
BAX_SATB1 FRAP1_TKT_CCNG2 FRAP1_CDH2_RPS19BP1_SESN1
LC3_NAMPT FRAP1_MMP2_VEGF FRAP1_LC3_CASP3_MMP2
KIAA1967_MMP2 FRAP1_MMP2_RAPTOR ID2_CDH2_HMGB2_SESN3
CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
ID2_CDH2_MMP2_RPS19BP1_SESN3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
BAX_FRAP1_LC3_BECN1_CDH2 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3
ID2_FASLG_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CCNG2_CDH2_STAT3 ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_FASLG_NAMPT_SESN3 AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3
ID2_CDH2_HMGB1_RPS19BP1_SESN3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3
ID2_CDH2_MMP2_NAMPT_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_BECN1_CDH2_KIAA1967 FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3
BAX_FRAP1_LC3_CDH2_RPS19BP1 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
ID2_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3
ID2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_HMGB1_TWIST1 FRAP1_LC3_BECN1_CDH2_RAGE_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
CSE1L_ID2_CDH2_RPS19BP1_SESN3 ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_SESN1_STAT3
BAX_FAS_FRAP1_LC3_CDH2 FRAP1_LC3_NNMT_CDH2_MMP2_STAT3
FAS_FRAP1_LC3_CDH2_RAPTOR FRAP1_LC3_NNMT_TKT_CDH2_STAT3
LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2_STAT3
FAS_FRAP1_LC3_CDH2_KIAA1967 FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3
AIFM1_FRAP1_LC3_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_LC3_BECN1_CASP3_STAT3 CBS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
ID2_CDH2_NAMPT_SESN3_STAT3 AKT1_ATG12_FAS_CDH2_STAT3_TP63
LC3_ID2_NAMPT_RPS19BP1_SESN3 LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_NNMT_MMP2_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_CASP3_CDH2_MMP2_STAT3
FRAP1_TKT_CASP3_CDH2_STAT3 ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3
LC3_HMGB1_RPS19BP1_STAT3_TWIST1 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_VEGF
CBS_FRAP1_LC3_CASP3_CDH2 BAX_FRAP1_LC3_TKT_BECN1_CDH2
FRAP1_LAMP1_TKT_CASP3_CDH2 FRAP1_LC3_NNMT_CASP3_CDH2_STAT3
ID2_CDH2_HMGB1_NAMPT_SESN3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
ID2_HMGB1_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_LC3_TKT_CDH2_KIAA1967 FRAP1_LC3_BECN1_CDH2_SESN1_STAT3
FRAP1_LC3_CASP3_CDH2_HMGB1 ID2_CDH2_FASLG_NAMPT_SESN3_STAT3
ATG7_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_TKT_MMP2 ATG5_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_RPS19BP1_SESN1_STAT3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
BAX_FRAP1_LC3_CDH2_MMP2 AIFM1_FRAP1_LC3_TKT_CDH2_STAT3
ID2_TCF3_CDH2_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG
FRAP1_TKT_CASP3_CDH2_FASLG DRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3
FAS_FRAP1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3
CBS_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CCNG2_CDH2_STAT3
FRAP1_LC3_CDH2_KIAA1967_MMP2 BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1
FAS_FRAP1_LC3_CASP3_CDH2 BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3
BAX_CBS_FRAP1_LC3_CDH2 FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1
FRAP1_LC3_TKT_CDH2_RAPTOR FRAP1_LC3_MMP9_CASP3_CDH2_STAT3
CDH1_ID2_MMP9_TCF3_RPS19BP1 CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3
七种的组合 八种的组合
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63
FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63
AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3
FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3
ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3
FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63
CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3
FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3 AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3
FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63
FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63
ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63
CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3
FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63
AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1 ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63
FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63
ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63
FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63
CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63
AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63
FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1 FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3
CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63
FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63
AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63
ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3
ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3
FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3
FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1 FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3
FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63
BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3
FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3
ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63
FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR CSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3
FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1
FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63
FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1
FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3
AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3
AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1
AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3
ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3
AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3
AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR
ATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3
CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3
优选的是，所述组合物或试剂盒用于预测A1组的存活预后，并且所述基因是选自下表5所示的基因或基因的组中的一种或多种。
[表5]
一种 两种的组合 三种的组合 四种的组合
ID2 CDH1_ID2 ATG12_CDH1_ID2 ATG12_CDH1_ID2_HMGB2
CDH1 ATG12_CDH1 CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2
LC3 LAMP1_ID2 ATG12_CDH1_HMGB2 ATG12_CDH1_ID2_AGER
TKT BNIP3_ID2 CDH1_ID2_AGER ATG12_CDH1_TCF3_HMGB2
AKT1 ATG12_ID2 DRAM_CDH1_ID2 ATG12_DRAM_CDH1_ID2
AIFM1 CDH1_HMGB2 E2F1_CDH1_ID2 AIFM1_CASP8_LC3_CDH1
BNIP3 ID2_HMGB2 CDH1_ID2_LAMP2 ATG12_CDH1_AGER_HMGB2
LAMP1 E2F1_ID2 TKT_CDH1_ID2 ATG12_CDH1_ID2_BECN1
FRAP1 TKT_ID2 LAMP1_CDH1_ID2 ATG12_DRAM_CDH1_HMGB2
DRAM_ID2 CDH1_ID2_MMP2 DRAM_CDH1_ID2_HMGB2
ATG5_ID2 ATG12_DRAM_CDH1 ATG12_CDH1_BHLHE41_HMGB2
ID2_BECN1 CSE1L_CDH1_ID2 CDH1_ID2_HMGB2_LAMP2
ID2_AGER CDH1_ID2_MMP9 ATG12_CDH1_BECN1_HMGB2
ID2_MMP2 BNIP3_CDH1_ID2 E2F1_CDH1_ID2_HMGB2
ATG3_ID2 CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41
ID2_LAMP2 ATG12_CDH1_BHLHE41 CDH1_ID2_BECN1_HMGB2
ULK1_CDH1 ULK1_CDH1_ID2 ATG12_ATG5_CDH1_HMGB2
CSE1L_ID2 LC3_CDH1_ID2 DRAM_CDH1_ID2_AGER
TKT_CDH1 ATG12_CDH1_TCF3 LAMP1_CDH1_ID2_HMGB2
LC3_CDH1 ATG5_CDH1_ID2 ATG12_BNIP3_CDH1_ID2
ID2_MMP9 ATG3_CDH1_ID2 ATG12_CSE1L_CDH1_ID2
LC3_ID2 DIABLO_CDH1_ID2 ATG12_CDH1_ID2_MMP2
FRAP1_ID2 CASP8_CDH1_ID2 ATG12_CASP8_CDH1_ID2
CASP8_ID2 ATG12_ULK1_CDH1 ATG12_ATG3_CDH1_HMGB2
ID2_CIAP2 ATG12_CDH1_BECN1 ATG12_CDH1_ID2_MMP9
ID2_UVRAG ATG12_BNIP3_ID2 CDH1_ID2_HMGB2_MMP2
DIABLO_ID2 CDH1_ID2_CIAP2 ATG12_ATG3_CDH1_ID2
DRAM_CDH1 CBS_CDH1_ID2 ATG12_CASP8_CDH1_HMGB2
ID2_SIRT1 CDH1_ID2_HMGB1 ATG12_LAMP1_CDH1_ID2
FAS_ID2 CDH1_ID2_SIRT1 CDH1_ID2_AGER_BECN1
CDH1_AGER LAMP1_ID2_HMGB2 ATG12_FAS_CDH1_HMGB2
ID2_STAT3 CDH1_ID2_UVRAG ATG12_TKT_CDH1_ID2
CBS_ID2 AIFM1_LC3_CDH1 CDH1_ID2_MMP9_HMGB2
CDH1_MMP2 ATG12_CDH1_AGER ATG12_CDH1_HMGB1_HMGB2
AKT1_ID2 CDH1_ID2_STAT3 ATG12_CDH1_MMP9_HMGB2
ID2_CDH2 ATG12_LAMP1_ID2 ATG12_ATG5_CDH1_ID2
ATG7_ID2 ATG12_LC3_CDH1 ATG5_CDH1_ID2_HMGB2
ID2_HMGB1 CDH1_AGER_HMGB2 ATG3_CDH1_ID2_HMGB2
ULK1_ID2 FAS_CDH1_ID2 ATG12_DIABLO_CDH1_ID2
CDH1_LAMP2 ATG7_CDH1_ID2 CSE1L_CDH1_ID2_HMGB2
ATG5_CDH1 ATG12_CDH1_MMP2 ATG12_CDH1_CIAP2_HMGB2
ID2_SATB1 ATG12_CASP8_CDH1 ATG12_CDH1_ID2_UVRAG
CDH1_MMP9 ATG12_TKT_CDH1 ATG12_CDH1_HMGB2_SESN3
ID2_RPS19BP1 BNIP3_ID2_HMGB2 LC3_CDH1_ID2_AGER
ID2_TCF3 E2F1_ID2_HMGB2 ATG12_CDH1_HMGB2_SIRT1
CSE1L_CDH1 ATG12_CDH1_MMP9 ATG12_E2F1_CDH1_ID2
AIFM1_CDH1 ATG12_CDH1_SESN2 ATG12_FAS_CDH1_ID2
ID2_SESN3 CDH1_ID2_CDH2 AIFM1_ATG3_LC3_CDH1
ID2_SESN2 AKT1_CDH1_ID2 ATG12_CDH1_HMGB2_MMP2
LAMP1_CDH1 LAMP1_ID2_BECN1 BNIP3_CDH1_ID2_HMGB2
AIFM1_LC3 CDH1_ID2_TCF3 ATG12_ULK1_CDH1_HMGB2
E2F1_CDH1 ATG12_CDH1_UVRAG TKT_CDH1_ID2_HMGB2
ID2_NAMPT ATG12_FAS_CDH1 ATG12_CDH1_ID2_LAMP2
DIABLO_CDH1 LAMP1_TKT_ID2 ATG12_LC3_CDH1_ID2
BNIP3_CDH1 LAMP1_ID2_AGER ATG12_CDH1_HMGB2_UVRAG
AKT1_CDH1 DRAM_LAMP1_ID2 CASP8_CDH1_ID2_HMGB2
CASP8_CDH1 ATG12_DIABLO_CDH1 DIABLO_CDH1_ID2_HMGB2
CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
ATG12_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2
DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_LAMP1_CDH1_ID2_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_ATG5_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_E2F1_CDH1_ID2_HMGB2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2
ATG12_ATG3_CDH1_ID2_HMGB2 ATG12_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_MMP2 ATG12_CDH1_ID2_AGER_HMGB2_SIRT1
ATG12_CASP8_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_MMP2
ATG12_BNIP3_CDH1_ID2_HMGB2 ATG12_CASP8_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_MMP9_HMGB2 ATG12_CDH1_ID2_AGER_CIAP2_HMGB2
LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_AGER_HMGB2
ATG12_CSE1L_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_TCF3_AGER_HMGB2
LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1_HMGB2
ATG12_DIABLO_CDH1_ID2_HMGB2 ATG12_FAS_CDH1_ID2_AGER_HMGB2
CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB1_HMGB2
CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2
CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_ATG3_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_CIAP2_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_UVRAG ATG12_DIABLO_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_AGER ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2
ATG12_DRAM_CDH1_TCF3_HMGB2 ATG12_CASP8_DRAM_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_AGER_BECN1 ATG12_DRAM_CDH1_ID2_HMGB2_MMP2
ATG12_DIABLO_CDH1_BHLHE41_HMGB2 ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2
ATG12_DIABLO_CDH1_HMGB2_SESN3 ATG12_CBS_CDH1_ID2_AGER_HMGB2
ATG12_FAS_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_HMGB2
ATG3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_UVRAG
CDH1_ID2_AGER_HMGB2_MMP2 ATG12_E2F1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_TCF3_HMGB2 ATG12_ATG5_CDH1_ID2_BECN1_HMGB2
ATG12_CDH1_TCF3_AGER_HMGB2 ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_HMGB1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2
AIFM1_ATG3_CASP8_LC3_CDH1 ATG12_DRAM_E2F1_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_HMGB2_SIRT1 ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3
ATG12_CDH1_TCF3_BECN1_HMGB2 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1
ATG12_DIABLO_CDH1_TCF3_BHLHE41 ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2
BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3
AIFM1_CASP8_DRAM_LC3_CDH1 AIFM1_ATG3_CASP8_LC3_CDH1_MMP9
ATG12_CDH1_ID2_HMGB2_LAMP2 ATG12_ATG3_CDH1_ID2_BECN1_HMGB2
ATG12_ATG3_CDH1_TCF3_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_STAT3
ATG12_LC3_CDH1_ID2_HMGB2 ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2
ATG12_TKT_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2
CASP8_CDH1_ID2_AGER_HMGB2 DRAM_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_TCF3_BHLHE41_HMGB2 DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG5_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2
ATG12_CSE1L_CDH1_ID2_AGER ATG12_BNIP3_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2
CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_LC3_CDH1_ID2_AGER_HMGB2
CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2_MMP2
AIFM1_CASP8_LC3_CDH1_MMP9 DRAM_LC3_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1
AIFM1_CASP8_DIABLO_LC3_CDH1 ATG12_TKT_CDH1_ID2_AGER_HMGB2
CDH1_ID2_AGER_HMGB1_HMGB2 DRAM_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_CDH1_ID2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_MMP9_BECN1_HMGB2
ATG12_LC3_CDH1_AGER_HMGB2 CSE1L_DRAM_CDH1_ID2_AGER_HMGB2
FAS_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_HMGB2
ATG12_CDH1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3_HMGB2
七种的组合 八种的组合
ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3
ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3
ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2
ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3
ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1
ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2
ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1
ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2 ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2
ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1
ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1
ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2
ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2
ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1
ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1
ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2
ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1
ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2
ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2
ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2
ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2
ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1
ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1
ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2
ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1
ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1
ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3
ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3
AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1
ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2
ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1
AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9 ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2
ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3
ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1
ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2
ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2
优选的是，所述组合物或试剂盒用于预测A1组的无病存活预后，并且所述基因是选自下表6所示的基因或基因的组中的一种或多种。
[表6]
一种 两种的组合 三种的组合 四种的组合
MMP2 ID2_CDH2 FRAP1_CASP3_CDH2 FRAP1_TKT_CASP3_CDH2
ID2 FRAP1_TWIST1 ID2_CDH2_SESN3 ID2_CDH2_MMP2_SESN3
TWIST1 FRAP1_CASP3 ID2_CDH2_MMP2 CBS_ID2_CDH2_SESN3
BECN1 FRAP1_SESN1 FRAP1_CDH2_TWIST1 FRAP1_TKT_CDH2_TWIST1
BAX BAX_FRAP1 FRAP1_CDH2_SESN1 FRAP1_LC3_CASP3_CDH2
BCL2L1 FRAP1_NNMT FRAP1_NNMT_CDH2 FRAP1_NNMT_TKT_CDH2
CDH2 FRAP1_CCNG2 AIFM1_FRAP1_CDH2 ID2_CDH2_RPS19BP1_SESN3
FASLG BCL2L1_FRAP1 FRAP1_TKT_TWIST1 BAX_FRAP1_TKT_CDH2
AGER FRAP1_RAGE BAX_FRAP1_CDH2 BAX_FRAP1_LC3_CDH2
ATG12 AIFM1_FRAP1 FRAP1_LC3_TWIST1 ATG12_ID2_CDH2_SESN3
TKT BCL2_FRAP1 AKT1_ID2_CDH2 ATG12_ID2_MMP2_SESN3
FRAP1_VEGF ATG12_ID2_MMP2 FRAP1_LC3_CDH2_KIAA1967
FRAP1_PTEN FRAP1_CDH2_KIAA1967 AIFM1_FRAP1_TKT_CDH2
HMGB1_TWIST1 FRAP1_CCNG2_CDH2 FRAP1_TKT_CDH2_SESN1
ATG12_ID2 FRAP1_NNMT_MMP2 ID2_MMP2_RPS19BP1_SESN3
FRAP1_RAPTOR FRAP1_CDH2_RAGE FRAP1_CDH2_SESN1_STAT3
FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1
ID2_BECN1 FRAP1_TKT_CASP3 FRAP1_LC3_NNMT_CDH2
BECN1_SESN3 ATG12_MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR
ATG12_MMP2 FRAP1_CDH2_VEGF FRAP1_TKT_CCNG2_CDH2
CDH2_SESN3 ID2_CDH2_HMGB1 DIABLO_ID2_CDH2_SESN3
ID2_MMP2 FRAP1_PTEN_CDH2 ID2_CDH2_HMGB2_SESN3
FRAP1_XIAP CDH1_ID2_CDH2 FRAP1_TKT_CDH2_KIAA1967
AKT1_CDH2 FRAP1_CASP3_MMP2 FRAP1_LC3_CDH2_RAGE
FRAP1_PRKAA1 FRAP1_LC3_CASP3 BAX_FRAP1_TKT_MMP2
ID2_RPS19BP1 BCL2_FRAP1_CDH2 BCL2L1_FRAP1_TKT_CDH2
TKT_MMP2 BAX_FRAP1_TKT FRAP1_CASP3_CDH2_STAT3
BAX_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_PTEN_TKT_CDH2
BECN1_FASLG BAX_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1
ATG12_SESN3 BAX_FRAP1_MMP2 ID2_CDH2_NAMPT_SESN3
CDH2_MMP2 FAS_ID2_CDH2 FRAP1_TKT_CDH2_VEGF
BECN1_MMP2 FRAP1_RPS19BP1_TWIST1 FRAP1_LC3_CDH2_VEGF
BAX_MMP2 FRAP1_LC3_NNMT FRAP1_NNMT_CDH2_MMP2
ID2_NAMPT FRAP1_LC3_RAGE AIFM1_FRAP1_LC3_CDH2
CASP8_ID2 FRAP1_HMGB1_TWIST1 FRAP1_LC3_PTEN_CDH2
ID2_TWIST1 FRAP1_SESN1_STAT3 FRAP1_TKT_CDH2_RAGE
MMP2_SESN3 FRAP1_TKT_SESN1 FRAP1_CDH2_HMGB1_TWIST1
AKT1_BAX ATG3_ID2_CDH2 FAS_FRAP1_CDH2_SESN1
FRAP1_TP63 FRAP1_ID2_CDH2 FRAP1_CASP3_CDH2_MMP2
BAX_LC3 FRAP1_TKT_CCNG2 DRAM_ID2_CDH2_SESN3
ATG12_FASLG FAS_FRAP1_TWIST1 LC3_HMGB1_STAT3_TWIST1
LC3_TWIST1 FRAP1_NNMT_TKT CASP8_ID2_CDH2_SESN3
AKT1_TWIST1 AIFM1_FRAP1_MMP2 FRAP1_TKT_CDH2_RAPTOR
ID2_FASLG ID2_CDH2_CIAP2 BCL2L1_FRAP1_LC3_CDH2
STAT3_TWIST1 FRAP1_LC3_VEGF FRAP1_CDH2_KIAA1967_MMP2
TKT_FASLG CDH2_MMP2_SESN3 FRAP1_TKT_CASP3_FASLG
AKT1_ATG12 ID2_CDH2_FASLG TKT_ID2_CDH2_MMP2
MMP2_NAMPT CBS_ID2_CDH2 FRAP1_NNMT_TKT_MMP2
ID2_SIRT1 FRAP1_LC3_CCNG2 FRAP1_TKT_CASP3_MMP2
ID2_AGER BCL2L1_FRAP1_TKT ID2_CDH2_CIAP2_SESN3
ATG7_TWIST1 FRAP1_ID2_TWIST1 FRAP1_CDH2_STAT3_TWIST1
AKT1_BCL2L1 AIFM1_FRAP1_LC3 CBS_FRAP1_CASP3_CDH2
BAX_TKT AIFM1_FRAP1_TKT BAX_FRAP1_CDH2_MMP2
KIAA1967_MMP2 ATG5_ID2_CDH2 ATG12_TKT_MMP2_SESN3
BCL2L1_MMP2 FRAP1_TKT_RAGE FRAP1_CDH1_CASP3_CDH2
ATG7_TP63 BCL2L1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2
LC3_BECN1 FRAP1_CDH2_TP63 ID2_CDH2_HMGB1_MMP2
CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_CDH2_STAT3_TP63
ATG12_ID2_CDH2_MMP2_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63
FRAP1_LC3_CASP3_CDH2_STAT3 AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63
ATG12_ID2_MMP2_RPS19BP1_SESN3 AKT1_FAS_LC3_CDH2_STAT3_TP63
AKT1_FAS_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_BECN1_CDH2_STAT3_TP63
CASP8_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63
FRAP1_TKT_CASP3_CDH2_FASLG ATG12_ID2_CDH2_HMGB1_MMP2_SESN3
BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3
ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3
DIABLO_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3
FRAP1_LAMP1_TKT_CASP3_CDH2 ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3
CBS_ID2_CDH2_MMP2_SESN3 ATG12_ID2_CDH2_CIAP2_MMP2_SESN3
FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3
FRAP1_TKT_CDH2_SESN1_STAT3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3
LC3_CDH2_HMGB1_STAT3_TWIST1 ATG12_FRAP1_ID2_CDH2_MMP2_SESN3
DRAM_ID2_CDH2_MMP2_SESN3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_SESN1_STAT3 ATG12_TKT_ID2_CDH2_MMP2_SESN3
CBS_FRAP1_TKT_CASP3_CDH2 ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3
ID2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_CASP8_FAS_CDH2_STAT3_TP63
AKT1_ID2_CDH2_RPS19BP1_SESN3 AKT1_FAS_CASP3_CDH2_STAT3_TP63
ID2_CDH2_MMP2_NAMPT_SESN3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3
AKT1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_TKT_CDH2_SESN1_STAT3
FAS_FRAP1_LC3_CDH2_RAPTOR ATG12_ID2_CDH2_MMP2_SESN3_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_NNMT_TKT_BECN1_CDH2_STAT3
BAX_FRAP1_TKT_CDH2_MMP2 ATG12_FAS_FRAP1_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_KIAA1967 ATG12_ATG3_ID2_CDH2_MMP2_SESN3
AKT1_ATG7_CDH2_RPS19BP1_TP63 DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3
FAS_FRAP1_LC3_CDH2_RAGE ATG12_CBS_ID2_CDH2_MMP2_SESN3
FAS_LC3_HMGB1_STAT3_TWIST1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3
FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CASP3_CDH2_CIAP2 AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3
TKT_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3
FRAP1_TKT_CDH2_KIAA1967_MMP2 ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_HMGB1_TWIST1 AKT1_FAS_CDH2_HMGB1_STAT3_TP63
BAX_FRAP1_LC3_BECN1_CDH2 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_STAT3_TWIST1 ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3
AKT1_ATG12_ID2_CDH2_SESN3 FRAP1_LC3_NNMT_TKT_CDH2_STAT3
BAX_FAS_FRAP1_LC3_CDH2 CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG12_CBS_ID2_MMP2_SESN3 AKT1_ATG12_CDH2_HMGB1_STAT3_TP63
FAS_FRAP1_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1
FRAP1_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_ID2_CDH2_MMP2_SESN3
FAS_FRAP1_TKT_CDH2_SESN1 ATG12_ATG5_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_CCNG2_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_STAT3_TP63
ID2_CDH2_MMP2_SESN3_UVRAG AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63
ATG7_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR
ID2_CDH2_HMGB1_RPS19BP1_SESN3 FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3
FRAP1_TKT_CDH2_MMP2_RAPTOR ATG12_CDH1_ID2_CDH2_MMP2_SESN3
FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_TKT_CDH2_STAT3_TWIST1
ATG12_ID2_CDH2_FASLG_SESN3 CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG7_FRAP1_TKT_CASP3_CDH2 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1
FRAP1_TKT_CASP3_CDH2_MMP2 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1
FRAP1_LC3_CDH2_HMGB1_TWIST1 ATG12_ID2_CDH2_HMGB2_MMP2_SESN3
FRAP1_LC3_TKT_CDH2_KIAA1967 ATG12_FAS_ID2_CDH2_MMP2_SESN3
ATG7_ID2_CDH2_RPS19BP1_TP63 TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3
BAX_FRAP1_TKT_BECN1_CDH2 BAX_FAS_FRAP1_LC3_TKT_CDH2
ATG3_FRAP1_TKT_CASP3_CDH2 ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3
CDH1_ID2_MMP9_TCF3_CDH2 CDH1_ID2_MMP9_TCF3_CDH2_SESN3
七种的组合 八种的组合
AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63
AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63
AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63
AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63
AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63
AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63
AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63
AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63
AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63
AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63
AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63
ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63
AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63
AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63
AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63
AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63
AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63
AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63
AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63
FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63
AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63
FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STAT3_TP63
ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_CASP8_FAS_NNMT_CDH2_STAT3_TP63
FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63
FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63
FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63
AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63
AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63
AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63
AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63
AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_CIAP2_STAT3_TP63
CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3
优选的是，所述组合物或试剂盒用于预测A2组的复发预后，并且所述基因是选自下表7所示的基因或基因的组中的一种或多种。
[表7]
一种 两种的组合 三种的组合 四种的组合
TKT PRKAA1_LAMP2 LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1
SESN2 TKT_SESN2 BNIP3_PRKAA1_LAMP2 ATG3_LC3_SESN2_SIRT1
LAMP2 ATG7_LAMP2 ATG5_LC3_SESN2 CSE1L_LC3_SESN2_SIRT1
LAMP2_SESN2 BNIP3_LC3_SESN2 ATG5_CSE1L_LC3_SESN2
AKT1_PRKAA1 ATG7_LC3_SESN2 BNIP3_LC3_SESN2_SIRT1
SESN2_SIRT1 AKT1_PRKAA1_LAMP2 FRAP1_LC3_SESN2_SIRT1
TKT_VEGF ATG7_TKT_SESN2 AKT1_ATG3_PRKAA1_LAMP2
ATG7_TKT DRAM_LC3_SESN2 ATG3_ATG5_LC3_SESN2
TKT_LAMP2 PRKAA1_AGER_LAMP2 ATG7_LC3_SESN2_SIRT1
BHLHE41_SESN2 PRKAA1_TKT_LAMP2 BNIP3_CSE1L_LC3_SESN2
TKT_BHLHE41 ATG7_TKT_LAMP2 TKT_LAMP2_SESN2_SIRT1
ATG5_SESN2 TKT_LAMP2_SESN2 CIAP2_LAMP2_SESN2_SIRT1
LAMP1_SESN2 TKT_LAMP2_VEGF ATG12_TKT_LAMP2_SESN2
CSE1L_LAMP2 ATG12_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
ATG12_SESN2 ATG7_LAMP2_SESN2 AKT1_ATG7_PRKAA1_LAMP2
AKT1_TKT TKT_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2
E2F1_SESN2 E2F1_LC3_SESN2 ATG3_BNIP3_LC3_SESN2
ATG3_LAMP2 LC3_SESN2_UVRAG AKT1_PRKAA1_LAMP2_UVRAG
BNIP3_SESN2 PRKAA1_CCNG2_LAMP2 DRAM_LC3_SESN2_SIRT1
LC3_SESN2 AKT1_ATG7_TKT ATG7_CSE1L_LC3_SESN2
TWIST1_VEGF ATG5_PRKAA1_LAMP2 ATG7_FRAP1_LC3_SESN2
ATG7_LC3 ATG3_LAMP2_SESN2 BNIP3_PRKAA1_LAMP2_SESN2
CSE1L_SESN2 BNIP3_TKT_SESN2 ATG5_ATG7_LC3_SESN2
ATG5_LC3 LAMP2_SESN2_SIRT1 PRKAA1_TKT_LAMP2_SESN2
ATG7_SESN2 ATG7_PRKAA1_LAMP2 ATG3_ATG7_LC3_SESN2
LC3_ULK1 LAMP1_LC3_SESN2 BNIP3_PRKAA1_AGER_LAMP2
ATG3_TKT ATG12_PRKAA1_LAMP2 E2F1_LC3_SESN2_SIRT1
DRAM_SESN2 CASP8_PRKAA1_LAMP2 LC3_ID2_SESN2_SIRT1
PRKAA1_TKT AIFM1_TKT_SESN2 LC3_NAMPT_SESN2_SIRT1
BHLHE41_LAMP2 FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2
LAMP2_VEGF PRKAA1_HMGB1_LAMP2 ATG7_BNIP3_LC3_SESN2
AKT1_VEGF LC3_BHLHE41_SESN2 LC3_RPS19BP1_SESN2_SIRT1
TKT_CIAP2 ATG12_TKT_SESN2 AKT1_ATG7_TKT_SESN2
CSE1L_BHLHE41 CSE1L_LAMP2_SESN2 BCL2L1_BNIP3_PRKAA1_LAMP2
LC3_BHLHE41 PRKAA1_CASP3_LAMP2 CSE1L_DRAM_LC3_SESN2
LC3_SIRT1 PRKAA1_LAMP2_RAGE DIABLO_LC3_SESN2_SIRT1
CSE1L_LAMP1 PRKAA1_LAMP2_SESN2 LC3_SESN2_SIRT1_STAT3
TKT_RPS19BP1 TKT_CIAP2_SESN2 ATG12_ATG5_LC3_SESN2
CBS_TKT BCL2L1_PRKAA1_LAMP2 BNIP3_PRKAA1_TCF3_LAMP2
CSE1L_BECN1 DIABLO_PRKAA1_LAMP2 LC3_SESN2_SIRT1_UVRAG
TKT_CDH1 PRKAA1_CDH1_LAMP2 BNIP3_PRKAA1_MMP9_LAMP2
TKT_HMGB1 CBS_PRKAA1_LAMP2 AKT1_LC3_SESN2_SIRT1
TKT_RAGE CSE1L_SESN2_SIRT1 AKT1_PRKAA1_CDH1_LAMP2
AIFM1_SESN2 ATG3_PRKAA1_LAMP2 CSE1L_LAMP1_LC3_SESN2
ATG7_TWIST1 PRKAA1_FASLG_LAMP2 ATG7_PRKAA1_TKT_LAMP2
BHLHE41_NAMPT PRKAA1_ID2_LAMP2 KIAA1967_LAMP2_SESN2_SIRT1
BNIP3_LC3 PRKAA1_LAMP2_SATB1 LC3_SESN2_SESN3_SIRT1
PRKAA1_SESN2 PRKAA1_LAMP2_SESN1 BNIP3_PRKAA1_HMGB1_LAMP2
ATG7_NAMPT AKT1_ATG7_PTEN CSE1L_LC3_SESN2_UVRAG
BECN1_SESN2 ATG7_TKT_BHLHE41 LC3_MMP9_SESN2_SIRT1
TKT_HMGB2 PRKAA1_LAMP2_MMP2 ATG3_LAMP2_SESN2_SIRT1
TKT_SIRT1 CSE1L_LAMP1_SESN2 BNIP3_PRKAA1_CCNG2_LAMP2
ATG5_CSE1L PRKAA1_LAMP2_SESN3 BNIP3_PRKAA1_LAMP2_SATB1
SESN2_UVRAG ATG3_TKT_SESN2 BNIP3_PRKAA1_LAMP2_SESN1
TKT_CASP3 ATG5_CSE1L_SESN2 ATG5_DRAM_LC3_SESN2
TKT_CDH2 ATG5_CSE1L_LC3 BNIP3_PRKAA1_CASP3_LAMP2
TKT_MMP2 FRAP1_PRKAA1_LAMP2 BNIP3_FRAP1_LC3_SESN2
五种的组合 六种的组合
CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_LC3_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TKT_CIAP2_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1
ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
TKT_CDH1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_BNIP3_LC3_SESN2_SIRT1 ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_LC3_SESN2_SIRT1 FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_LC3_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1
BNIP3_FRAP1_LC3_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_PRKAA1_TKT_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_LAMP2_SESN2_SIRT1 ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_ATG7_LC3_SESN2_SIRT1 BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1
AKT1_ATG7_BNIP3_PRKAA1_LAMP2 ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_SESN2_SIRT1 CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_BNIP3_LC3_SESN2 FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_LC3_SESN2_SIRT1 MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_DRAM_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
AIFM1_CIAP2_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_SESN2_SIRT1 CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_SESN2 LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG7_LC3_NAMPT_SESN2_SIRT1 TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG5_E2F1_LC3_SESN2_SIRT1 ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1
ATG7_LC3_LAMP2_SESN2_SIRT1 ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1
AIFM1_BNIP3_PRKAA1_LAMP2_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG12_BNIP3_TKT_LAMP2_SESN2 ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1
CIAP2_KIAA1967_LAMP2_SESN2_SIRT1 E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG12_ATG5_BNIP3_LC3_SESN2 ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG3_ATG7_LC3_LAMP2_SESN2 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG12_TKT_CIAP2_LAMP2_SESN2 ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_BNIP3_CSE1L_LC3_SESN2 TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1
AKT1_ATG7_PRKAA1_TKT_LAMP2 ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1
ATG3_LC3_NAMPT_SESN2_SIRT1 ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1
ATG3_CSE1L_LC3_SESN2_SIRT1 AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_LC3_ID2_SESN2_SIRT1 CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1
BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_ID2_SESN2_SIRT1
ATG3_LC3_ID2_SESN2_SIRT1 AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1
AIFM1_TKT_LAMP2_SESN2_SIRT1 ATG3_ATG5_E2F1_LC3_SESN2_SIRT1
LC3_CIAP2_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1
ATG12_TKT_CDH1_LAMP2_SESN2 ATG3_ATG5_LC3_SESN2_SIRT1_STAT3
ATG5_LC3_SESN2_SIRT1_STAT3 AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG
ATG3_DRAM_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1
ATG5_DIABLO_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1
ATG7_BNIP3_LC3_SESN2_SIRT1 ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1
CDH2_CIAP2_LAMP2_SESN2_SIRT1 TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_SESN2 ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1
DRAM_TKT_LAMP2_SESN2_SIRT1 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG12_ATG3_TKT_LAMP2_SESN2 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG3_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_LC3_SESN2_SIRT1
ATG5_LC3_SESN2_SIRT1_UVRAG AIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2
TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合 八种的组合
ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1
MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1
LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1
FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3
CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1
ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1
LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1
AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1
NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1
BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3
ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN1_SESN2_SIRT1
LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1
LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1
AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1
FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1
CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1
CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1
ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1
ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1
LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1
CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1
TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1
FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1
NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1
ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1
MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1
BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1
优选的是，所述组合物或试剂盒用于预测A2组的存活预后，并且所述基因是选自下表8所示的基因或基因的组中的一种或多种。
[表8]
一种 两种的组合 三种的组合 四种的组合
BCL2L1 BCL2L1_NNMT BCL2L1_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1
FAS BCL2L1_E2F1 BCL2L1_E2F1_PRKAA1 BCL2L1_TKT_CASP3_SESN2
LAMP1 BCL2L1_TKT ATG3_BCL2L1_PRKAA1 BCL2L1_ID2_CASP3_SESN2
BHLHE41 FAS_LAMP1 ATG3_BCL2L1_NNMT ATG3_BCL2L1_E2F1_PRKAA1
TKT BCL2L1_PRKAA1 ATG3_BCL2L1_E2F1 BCL2L1_NNMT_PRKAA1_HMGB1
LC3 FAS_BHLHE41 FAS_BHLHE41_SESN2 BCL2L1_NNMT_PRKAA1_MMP2
SESN2 FAS_TKT BCL2L1_PRKAA1_HMGB2 BCL2L1_NNMT_PRKAA1_CDH1
BCL2L1_CASP3 BCL2L1_CASP3_SESN2 FAS_TKT_CASP3_SESN2
ATG3_BCL2L1 BCL2L1_PRKAA1_TKT BCL2L1_NNMT_PRKAA1_VEGF
ATG7_BCL2L1 FAS_CASP3_SESN2 ATG7_BCL2L1_NNMT_PRKAA1
FAS_CASP3 BCL2L1_TKT_CASP3 BCL2L1_FRAP1_NNMT_PRKAA1
TKT_BHLHE41 FAS_TKT_CASP3 BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_KIAA1967 BCL2L1_E2F1_TKT AIFM1_BCL2L1_NNMT_PRKAA1
FAS_PRKAA1 BCL2L1_NNMT_TKT BCL2L1_TKT_BHLHE41_CASP3
FAS_KIAA1967 FAS_TKT_BHLHE41 BCL2L1_NNMT_PRKAA1_CDH2
FAS_SESN2 FAS_TKT_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1
BCL2L1_HMGB2 FAS_LAMP1_BHLHE41 BCL2L1_NNMT_PRKAA1_HMGB2
BCL2L1_VEGF FAS_LAMP1_SESN2 BCL2L1_CBS_NNMT_PRKAA1
BNIP3_FAS ATG3_BCL2L1_TKT FAS_TKT_SESN2_TP63
FAS_TWIST1 ATG7_BCL2L1_PRKAA1 BCL2L1_DRAM_NNMT_PRKAA1
BNIP3_TKT DIABLO_FAS_BHLHE41 BCL2L1_NNMT_PRKAA1_ULK1
BCL2L1_CSE1L TKT_SESN2_TP63 BNIP3_TKT_CASP3_SESN2
TKT_SESN2 FAS_PRKAA1_TKT ATG5_BCL2L1_NNMT_PRKAA1
BCL2L1_FRAP1 ATG7_BCL2L1_NNMT BCL2L1_DIABLO_NNMT_PRKAA1
LAMP1_SESN2 BCL2L1_BNIP3_TKT BCL2L1_NNMT_CASP3_SESN2
LC3_BHLHE41 BNIP3_FAS_TKT FAS_TKT_BHLHE41_CASP3
BCL2L1_BNIP3 BCL2L1_NNMT_CASP3 BCL2L1_NNMT_PRKAA1_TKT
BCL2L1_LC3 TKT_BHLHE41_CASP3 BNIP3_FAS_TKT_CASP3
ATG5_BCL2L1 ATG3_BCL2L1_CASP3 ATG3_ATG7_BCL2L1_PRKAA1
BCL2L1_CBS BCL2L1_PRKAA1_CASP3 FAS_ID2_CASP3_SESN2
CSE1L_LAMP1 BCL2L1_PRKAA1_MMP2 BCL2L1_NNMT_PRKAA1_CASP3
E2F1_FAS FAS_BHLHE41_CASP3 ATG3_BCL2L1_PRKAA1_HMGB2
AIFM1_BCL2L1 FAS_TKT_KIAA1967 FAS_LC3_BHLHE41_SESN2
BHLHE41_SESN2 FAS_TKT_TWIST1 ATG3_BCL2L1_BNIP3_NNMT
CASP8_FAS BCL2L1_E2F1_NNMT BCL2L1_CASP8_NNMT_PRKAA1
FAS_NAMPT BCL2L1_FRAP1_NNMT FAS_BHLHE41_CASP3_SESN2
FAS_TP63 BCL2L1_TKT_BHLHE41 BCL2L1_BNIP3_NNMT_TKT
LAMP1_BHLHE41 BCL2L1_TKT_SESN2 DIABLO_FAS_BHLHE41_SESN2
ATG12_FAS FAS_KIAA1967_SESN2 ATG3_BCL2L1_PRKAA1_TKT
BCL2L1_MMP2 DIABLO_FAS_LAMP1 BCL2L1_NNMT_PRKAA1_MMP9
BHLHE41_CASP3 ATG3_BCL2L1_KIAA1967 BNIP3_FAS_CASP3_SESN2
FAS_HMGB1 ATG7_BCL2L1_E2F1 FAS_LAMP1_BHLHE41_SESN2
FAS_VEGF FAS_BHLHE41_SATB1 BCL2L1_CASP3_SESN1_SESN2
LAMP1_TCF3 ATG3_ATG7_BCL2L1 BCL2L1_NNMT_PRKAA1_SIRT1
BCL2L1_ULK1 ATG7_BCL2L1_TKT DIABLO_FAS_LAMP1_BHLHE41
FAS_LC3 BCL2L1_BNIP3_NNMT FAS_TKT_CASP3_SIRT1
NNMT_BHLHE41 BCL2L1_PRKAA1_VEGF E2F1_FAS_BHLHE41_SESN2
BCL2L1_FAS BCL2L1_BHLHE41_CASP3 FAS_TKT_CASP3_FASLG
TKT_TP63 FAS_SESN2_TP63 FAS_TKT_HMGB1_SESN2
AKT1_BCL2L1 TKT_BHLHE41_TP63 FAS_CASP3_HMGB1_SESN2
ATG12_BCL2L1 AIFM1_BCL2L1_NNMT BAX_BCL2L1_NNMT_PRKAA1
FAS_HMGB2 BCL2L1_CSE1L_NNMT BCL2L1_E2F1_NNMT_PRKAA1
BCL2L1_ID2 BCL2L1_E2F1_FRAP1 ATG3_BCL2L1_PRKAA1_MMP2
BCL2L1_RPS19BP1 BNIP3_FAS_CASP3 FAS_TKT_KIAA1967_SESN2
TKT_SATB1 FAS_TKT_SATB1 BNIP3_FAS_TKT_TWIST1
FAS_XIAP BCL2L1_CSE1L_PRKAA1 ATG3_BCL2L1_BNIP3_TKT
BCL2_BCL2L1 BCL2L1_NNMT_VEGF BCL2L1_NNMT_PRKAA1_PTEN
五种的组合 六种的组合
BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2
BCL2L1_PTEN_TKT_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_HMGB1 ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1
BCL2L1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2
BCL2L1_BNIP3_TKT_CASP3_SESN2 FAS_TKT_CASP3_HMGB1_SESN2_TP63
ATG3_BCL2L1_NNMT_PRKAA1_CDH1 ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1
BCL2L1_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ULK1 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF
FAS_TKT_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2
FAS_TKT_CASP3_SESN2_TP63 BCL2L1_NNMT_ID2_AGER_CASP3_SESN2
ATG3_BCL2L1_FRAP1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2
FAS_TKT_HMGB1_SESN2_TP63 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2
AIFM1_ATG3_BCL2L1_NNMT_PRKAA1 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_SESN1_SESN2 ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_MMP2 BNIP3_TKT_XIAP_CASP3_RAGE_SESN2
BCL2L1_TKT_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_VEGF AIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2
ATG3_BCL2L1_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2
BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2
BCL2L1_NNMT_PRKAA1_ID2_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG
BCL2L1_NNMT_PRKAA1_HMGB1_VEGF BCL2L1_NNMT_ID2_CASP3_SESN2_SESN3
ATG3_BCL2L1_NNMT_PRKAA1_CDH2 BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_LAMP1_NNMT_PRKAA1 BAX_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_SESN2_UVRAG BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2
ATG3_ATG7_BCL2L1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2
ATG3_BCL2L1_CBS_NNMT_PRKAA1 BNIP3_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2
BNIP3_FAS_TKT_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2
ATG3_BCL2L1_DRAM_NNMT_PRKAA1 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1
ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2
BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2 ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2
BCL2L1_FAS_TKT_CASP3_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2
ATG3_BCL2L1_CSE1L_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF
ATG3_BCL2L1_DIABLO_NNMT_PRKAA1 BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2
BCL2L1_CASP8_ID2_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2
BCL2L1_DIABLO_ID2_CASP3_SESN2 BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_STAT3 BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_ID2_VEGF BCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2
BCL2L1_ID2_CASP3_HMGB2_SESN2 BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2
BCL2L1_TKT_CASP3_SESN2_SESN3 BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2
BCL2L1_TKT_CASP3_CCNG2_SESN2 BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2
FAS_TKT_CASP3_FASLG_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2
FAS_TKT_CASP3_SESN2_SIRT1 BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2
BCL2L1_NNMT_ID2_KIAA1967_SESN2 BNIP3_FAS_TKT_CASP3_HMGB1_SESN2
ATG5_BCL2L1_ID2_CASP3_SESN2 FAS_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG
BCL2L1_TKT_XIAP_BHLHE41_CASP3 FAS_TKT_HMGB1_KIAA1967_SESN2_TP63
FAS_TKT_XIAP_CASP3_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2
BCL2L1_CDH1_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_ID2_CASP3_SESN2
BCL2L1_TKT_CASP3_SESN2_SIRT1 BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2
ATG7_BCL2L1_NNMT_PRKAA1_ID2 BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2_BCL2L1_TKT_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2
BCL2L1_ID2_CASP3_CDH2_SESN2 BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2
七种的组合 八种的组合
BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2
BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3
BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2
BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2
ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3
BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2
BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2
BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2
BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2
BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2
BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3
BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2
BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2
BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2
BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3
ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2
ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2
BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2
BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2
BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3
ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2
BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2
BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2
BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2
BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2
BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2
BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2
BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2
BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2
BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2
BCL2L1_NNMT_ID2_AGER_CASP3_RAGE_SESN2 AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2
BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2
BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2
BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2
ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2CASP3_HMGB1_RAGE_SESN2
BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2
BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967
BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3
BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2
BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3
BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2
BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3
ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2
BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2
BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2
优选的是，所述组合物或试剂盒用于预测A2组的无病存活预后，并且所述基因是选自下表9所示的基因或基因的组中的一种或多种。
[表9]
一种 两种的组合 三种的组合 四种的组合
SESN2 TKT_SESN2 ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2
TKT BHLHE41_SESN2 FRAP1_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1
LAMP2 LAMP2_SESN2 ATG5_LC3_SESN2 ATG7_TKT_LAMP2_SESN2
BHLHE41 ATG5_SESN2 ATG5_FRAP1_SESN2 ATG5_FRAP1_SESN2_SIRT1
CSE1L LAMP1_SESN2 TKT_LAMP2_SESN2 AKT1_ATG7_TKT_SESN2
SESN2_SIRT1 AIFM1_TKT_SESN2 ATG5_CSE1L_LC3_SESN2
E2F1_SESN2 ATG5_CSE1L_SESN2 FRAP1_LC3_SESN2_SIRT1
ATG12_SESN2 LC3_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_SESN2
TKT_VEGF ATG12_TKT_SESN2 ATG7_TKT_SESN2_SESN3
CSE1L_BECN1 CSE1L_LAMP1_SESN2 ATG5_FRAP1_LC3_SESN2
CSE1L_SESN2 TKT_HMGB2_SESN2 ATG7_CSE1L_FRAP1_SESN2
ATG7_TKT ATG5_TKT_SESN2 CSE1L_LC3_SESN2_SIRT1
FASLG_SESN2 TKT_CDH1_SESN2 ATG5_LC3_SESN2_SIRT1
PRKAA1_LAMP2 TKT_SESN2_SESN3 ATG7_TKT_FASLG_SESN2
PRKAA1_SESN2 TKT_SESN2_VEGF ATG7_TKT_AGER_SESN2
TKT_BHLHE41 CSE1L_BHLHE41_SESN2 ATG7_TKT_HMGB1_SESN2
CSE1L_BHLHE41 PRKAA1_TKT_SESN2 ATG7_TKT_MMP2_SESN2
ATG7_SESN2 ATG3_TKT_SESN2 BNIP3_CSE1L_FRAP1_SESN2
CSE1L_LAMP2 TKT_RPS19BP1_SESN2 ATG5_ATG7_TKT_SESN2
FAS_SESN2 CBS_TKT_SESN2 ATG7_BCL2_TKT_SESN2
HMGB2_SESN2 CSE1L_LAMP2_SESN2 ATG7_BNIP3_TKT_SESN2
CSE1L_LAMP1 TKT_SESN2_SIRT1 FAS_FRAP1_SESN2_SIRT1
BECN1_SESN2 AKT1_TKT_SESN2 AIFM1_ATG7_TKT_SESN2
NNMT_SESN2 CSE1L_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2
AIFM1_SESN2 TKT_CDH2_SESN2 ATG7_TKT_BHLHE41_SESN2
BAX_SESN2 BNIP3_TKT_SESN2 ATG7_TKT_ID2_SESN2
DRAM_SESN2 NNMT_TKT_SESN2 CSE1L_DRAM_FRAP1_SESN2
CSE1L_ULK1 TKT_AGER_SESN2 CSE1L_FRAP1_SESN2_UVRAG
KIAA1967_SESN2 TKT_BHLHE41_SESN2 ATG7_LAMP1_TKT_SESN2
SESN2_VEGF TKT_HMGB1_SESN2 ATG7_BCL2L1_TKT_SESN2
BNIP3_SESN2 TKT_MMP2_SESN2 ATG7_TKT_CCNG2_SESN2
SESN2_UVRAG E2F1_TKT_SESN2 CSE1L_E2F1_FRAP1_SESN2
TWIST1_VEGF NAMPT_SESN2_SIRT1 CSE1L_LAMP1_LC3_SESN2
PRKAA1_FASLG TKT_KIAA1967_SESN2 PRKAA1_TKT_LAMP2_SESN2
TKT_RPS19BP1 DRAM_TKT_SESN2 ATG7_CBS_TKT_SESN2
PRKAA1_TKT TKT_CIAP2_SESN2 ATG7_LC3_TKT_SESN2
ATG7_LAMP2 TKT_MMP9_SESN2 ATG7_NNMT_TKT_SESN2
AGER_SESN2 ATG5_NAMPT_SESN2 ATG7_TKT_CIAP2_SESN2
CDH2_SESN2 ATG7_FRAP1_SESN2 ATG7_TKT_SESN2_STAT3
AKT1_PRKAA1 CSE1L_E2F1_SESN2 ATG7_PTEN_TKT_SESN2
ULK1_SESN2 LAMP1_TKT_SESN2 ATG7_TKT_CASP3_SESN2
MMP2_SESN2 LC3_TKT_SESN2 ATG7_TKT_CDH2_SESN2
ATG5_CSE1L TKT_CASP3_SESN2 ATG7_TKT_HMGB2_SESN2
HMGB1_SESN2 TKT_CCNG2_SESN2 ATG7_TKT_NAMPT_SESN2
AKT1_TKT TKT_ID2_SESN2 ATG7_TKT_RAPTOR_SESN2
CBS_SESN2 TKT_RAPTOR_SESN2 ATG7_TKT_SESN2_SIRT1
FRAP1_SESN2 TKT_XIAP_SESN2 ATG7_FRAP1_LC3_SESN2
CIAP2_SESN2 BAX_TKT_SESN2 ATG7_TKT_BECN1_SESN2
BCL2_SESN2 BCL2_TKT_SESN2 ATG7_DIABLO_TKT_SESN2
CCNG2_SESN2 ATG12_CSE1L_SESN2 ATG7_FRAP1_SESN2_SIRT1
BCL2L1_SESN2 BCL2L1_TKT_SESN2 ATG12_CSE1L_FRAP1_SESN2
CSE1L_UVRAG CASP8_TKT_SESN2 ATG7_TKT_XIAP_SESN2
RAPTOR_SESN2 DIABLO_TKT_SESN2 ATG7_E2F1_TKT_SESN2
XIAP_SESN2 FAS_BHLHE41_SESN2 ATG7_TKT_MMP9_SESN2
CASP3_SESN2 FRAP1_TKT_SESN2 ATG7_TKT_RAGE_SESN2
CASP8_SESN2 PTEN_TKT_SESN2 ATG3_ATG7_TKT_SESN2
LC3_SESN2 TKT_RAGE_SESN2 ATG7_CSE1L_LC3_SESN2
五种的组合 六种的组合
ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LAMP1_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG7_TKT_LAMP2_SESN2 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG5_FRAP1_LAMP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2
CSE1L_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2
AKT1_ATG5_CSE1L_FRAP1_SESN2 ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1
ATG5_CSE1L_DIABLO_FRAP1_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2
ATG5_CSE1L_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3
CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG7_TKT_LAMP2_SESN2_SESN3 AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_SATB1_SESN2_SIRT1 ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_CDH1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG7_TKT_FASLG_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_CSE1L_FRAP1_ID2_SESN2 CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1
AKT1_ATG7_TKT_SESN2_SESN3 CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG7_TKT_LAMP2_MMP2_SESN2 CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
AKT1_CSE1L_FRAP1_SESN2_SIRT1 AKT1_ATG5_FRAP1_LC3_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2
ATG5_CSE1L_FRAP1_SESN2_SESN3 ATG5_FRAP1_LC3_ID2_SESN2_SIRT1
CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_SESN2 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_LC3_SESN2 ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1
ATG3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2
ATG5_ATG7_FRAP1_LC3_SESN2 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2
ATG5_FAS_FRAP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
CSE1L_FRAP1_SESN2_SESN3_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
CSE1L_DRAM_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG
CSE1L_DIABLO_FRAP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2
ATG7_CSE1L_FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1
ATG5_CSE1L_FRAP1_CDH1_SESN2 ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1
ATG7_TKT_FASLG_SESN2_SESN3 ATG5_CSE1L_FRAP1_CDH1_SESN2_SIRT1
ATG7_TKT_HMGB1_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG7_TKT_AGER_LAMP2_SESN2 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_FRAP1_SESN2_SIRT1 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_SATB1_SESN2 ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1
CSE1L_FRAP1_ID2_SESN2_SIRT1 CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1
ATG7_BNIP3_TKT_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3
ATG5_ATG7_CSE1L_FRAP1_SESN2 AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2
ATG5_LC3_NAMPT_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG
ATG12_ATG5_CSE1L_FRAP1_SESN2 CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1
CSE1L_FRAP1_SESN2_SIRT1_STAT3 CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1
CSE1L_FRAP1_LC3_SESN2_UVRAG ATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2
AKT1_ATG7_TKT_MMP2_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1
ATG5_BNIP3_CSE1L_FRAP1_SESN2 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2
CSE1L_FRAP1_MMP9_SESN2_SIRT1 CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1
BNIP3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2
AKT1_ATG7_TKT_HMGB1_SESN2 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2
AIFM1_AKT1_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1
AKT1_ATG5_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1
ATG12_ATG7_TKT_LAMP2_SESN2 ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1
CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合 八种的组合
ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2
ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1
AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1
ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAG
AKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2
ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2
ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG
AIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAG
ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1
ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAG
ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2SESN2_SIRT1_UVRAG
ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1
AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1
ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1
ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1
ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1
AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1
ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3
ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1
AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1
ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1
AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1
AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1
ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1
ATG7_TKT_CDH1_ID2MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1
优选的是，所述组合物或试剂盒用于预测B组的复发预后，并且所述基因是选自下表10所示的基因或基因的组中的一种或多种。
[表10]
一种 两种的组合 三种的组合 四种的组合
HMGB1 ATG3_HMGB1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
TKT ATG3_BECN1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
TKT_HMGB1 ATG3_TKT_HMGB1 ATG3_BCL2_TKT_HMGB1
BCL2L1_TKT ATG3_CDH1_HMGB1 ATG3_BCL2_HMGB1_RAGE
ATG3_NAMPT ATG3_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2
BCL2_HMGB1 ATG3_HMGB1_UVRAG ATG3_CDH1_HMGB1_SIRT1
HMGB1_TWIST1 ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_MMP2
ATG12_ATG3 ATG3_HMGB1_SIRT1 ATG3_HMGB1_HMGB2_RAGE
CSE1L_DIABLO ATG3_BECN1_SATB1 ATG3_BCL2_BNIP3_HMGB1
ATG3_TKT ATG3_HMGB1_SATB1 ATG3_CDH1_CASP3_HMGB1
LAMP1_HMGB1 ATG3_LC3_BECN1 ATG3_CDH1_HMGB1_KIAA1967
TKT_BECN1 ATG3_HMGB1_LAMP2 ATG3_HMGB1_RAGE_UVRAG
CDH1_HMGB1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_RAGE_SIRT1
HMGB1_TP63 ATG3_HMGB1_KIAA1967 ATG3_TKT_HMGB1_HMGB2
TKT_NAMPT BCL2L1_TKT_CASP3 ATG3_TKT_HMGB1_UVRAG
BCL2_TKT ATG12_ATG3_HMGB1 ATG3_BCL2_LAMP1_HMGB1
CSE1L_TKT BCL2L1_TKT_SIRT1 ATG3_BCL2_HMGB1_RAPTOR
LC3_TKT ATG3_CIAP2_HMGB1 AIFM1_ATG3_BCL2_HMGB1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_CASP3_HMGB1_RAGE
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG12_ATG3_HMGB1_RAGE
CDH2_HMGB1 ATG3_BECN1_SESN3 ATG3_TKT_CASP3_HMGB1
ATG5_HMGB1 ATG3_CASP8_HMGB1 ATG3_TKT_HMGB1_KIAA1967
HMGB1_SIRT1 ATG3_CDH2_HMGB1 ATG3_BCL2L1_TKT_BECN1
ATG12_HMGB1 ATG3_FRAP1_HMGB1 ATG12_ATG3_CDH1_HMGB1
HMGB1_RAGE ATG3_BNIP3_HMGB1 ATG3_CDH1_HMGB1_RAGE
HMGB1_UVRAG ATG3_BECN1_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_SIRT1 ATG3_CBS_HMGB1 ATG3_BCL2_HMGB1_LAMP2
ATG3_TCF3 AIFM1_ATG3_HMGB1 ATG3_BCL2_DIABLO_HMGB1
BCL2L1_HMGB1 ATG3_HMGB1_STAT3 ATG3_TKT_HMGB1_SIRT1
TKT_SIRT1 ATG3_HMGB1_MMP2 ATG3_BCL2_CBS_HMGB1
HMGB1_LAMP2 ATG3_LAMP1_HMGB1 ATG3_BCL2_CASP8_HMGB1
TKT_SESN2 BCL2L1_TKT_FASLG ATG3_HMGB1_HMGB2_SATB1
HMGB1_MMP2 ATG3_DIABLO_HMGB1 ATG3_BCL2_PTEN_HMGB1
TKT_AGER BCL2_BCL2L1_TKT ATG3_HMGB1_RAGE_RAPTOR
HMGB1_RAPTOR TKT_HMGB1_TWIST1 ATG3_TKT_HMGB1_RAGE
E2F1_HMGB1 ATG3_NNMT_HMGB1 ATG3_BCL2_CASP3_HMGB1
CASP8_HMGB1 ATG3_MMP9_HMGB1 ATG3_BCL2_HMGB1_SATB1
TKT_ID2 BCL2L1_TKT_HMGB1 ATG3_HMGB1_LAMP2_RAGE
AKT1_TKT ATG3_LAMP1_BECN1 ATG3_CDH1_HMGB1_LAMP2
ATG3_SIRT1 ATG3_BCL2L1_BECN1 ATG3_HMGB1_HMGB2_UVRAG
TKT_RPS19BP1 ATG5_TKT_HMGB1 ATG3_BCL2L1_TKT_HMGB1
CSE1L_HMGB1 ATG3_FASLG_HMGB1 CDH1_HMGB1_TP63_UVRAG
BCL2L1_BECN1 ATG3_MMP9_BECN1 ATG3_CDH1_HMGB1_HMGB2
CASP3_HMGB1 ATG3_ATG7_BECN1 ATG3_BCL2L1_TKT_CASP3
ATG7_HMGB1 ATG3_HMGB1_SESN3 ATG3_HMGB1_KIAA1967_RAGE
FRAP1_HMGB1 ATG3_E2F1_HMGB1 ATG3_BCL2_DRAM_HMGB1
HMGB1_HMGB2 HMGB1_RAPTOR_TWIST1 ATG3_LC3_TKT_HMGB1
HMGB1_SATB1 AKT1_ATG3_BECN1 ATG3_BCL2_HMGB1_UVRAG
ATG3_ULK1 ATG3_FAS_HMGB1 ATG3_CDH1_CDH2_HMGB1
ATG3_SESN1 ATG3_ULK1_HMGB1 BCL2_BCL2L1_TKT_CASP3
CBS_HMGB1 TKT_HMGB1_SIRT1 ATG3_TKT_BECN1_HMGB1
TKT_KIAA1967 ATG3_BAX_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG12_BCL2L1 TKT_CDH2_HMGB1 ATG3_BCL2_PRKAA1_HMGB1
DRAM_HMGB1 ATG3_PTEN_HMGB1 BCL2L1_TKT_CASP3_SIRT1
LC3_FASLG ATG3_TKT_BECN1 BCL2L1_TKT_CASP3_FASLG
HMGB1_KIAA1967 ATG3_HMGB1_TWIST1 BCL2L1_TKT_CASP3_CDH2
TKT_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2_NNMT_HMGB1
五种的组合 六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE
ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE
ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2
ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967
ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE
ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1
ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2CASP3_HMGB2_UVRAG
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1
ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1
ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1
ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG
ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG
ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967
AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1
ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR
ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG
ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG
ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE
ATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG
优选的是，所述组合物或试剂盒用于预测B组的存活预后，并且所述基因是选自下表11所示的基因或基因的组中的一种或多种。
[表11]
一种 两种的组合 三种的组合 四种的组合
ATG12 DIABLO_NAMPT DIABLO_ID2_NAMPT ATG12_ID2_MMP9_TCF3
DIABLO ATG12_ID2 DIABLO_FAS_NAMPT DIABLO_FAS_ID2_NAMPT
UVRAG ATG12_RPS19BP1 ATG12_ID2_TCF3 ATG12_CSE1L_ID2_MMP9
NAMPT ATG12_DIABLO DIABLO_FAS_STAT3 DIABLO_ID2_MMP9_NAMPT
STAT3 ID2_NAMPT ATG12_ID2_MMP9 DIABLO_FAS_MMP9_NAMPT
E2F1 DIABLO_STAT3 ATG12_ID2_SATB1 DIABLO_ID2_NAMPT_STAT3
BECN1 DIABLO_FAS ATG12_ID2_RPS19BP1 ATG12_FAS_ID2_MMP9
FRAP1 ATG12_CSE1L ATG12_CSE1L_ID2 ATG12_ID2_MMP9_SATB1
ATG7 ATG12_MMP9 ATG12_DIABLO_FAS DIABLO_ID2_NAMPT_SATB1
ID2 ATG12_ATG3 ATG12_ID2_SESN2 ATG12_ID2_MMP9_SESN2
SIRT1 ATG12_SATB1 ATG12_ID2_NAMPT ATG12_ID2_MMP9_RPS19BP1
BCL2 ATG12_SESN2 ATG12_CSE1L_DIABLO CSE1L_DIABLO_ID2_NAMPT
BNIP3 CSE1L_DIABLO ID2_NAMPT_STAT3 DIABLO_ID2_TCF3_NAMPT
LAMP2 ATG12_TCF3 ATG12_ID2_BHLHE41 DIABLO_FAS_NAMPT_SATB1
TKT ATG12_FAS CSE1L_DIABLO_NAMPT ATG12_DIABLO_FAS_MMP9
ATG12_STAT3 DIABLO_LC3_NAMPT DIABLO_FAS_ID2_STAT3
ATG12_BHLHE41 ATG12_FAS_ID2 ATG12_ATG3_ID2_TCF3
ATG12_NAMPT ID2_NAMPT_RPS19BP1 ATG3_DIABLO_ID2_NAMPT
ATG12_ATG7 ID2_MMP9_TCF3 ATG12_ID2_TCF3_STAT3
ID2_BECN1 DIABLO_NAMPT_SATB1 DIABLO_FAS_NAMPT_STAT3
E2F1_FAS ATG12_CSE1L_MMP9 ATG12_CSE1L_DIABLO_MMP9
ATG12_ATG5 ATG12_MMP9_RPS19BP1 ATG12_ID2_TCF3_SATB1
ID2_STAT3 ID2_MMP9_BECN1 DIABLO_FAS_MMP9_STAT3
ATG12_ULK1 DIABLO_NAMPT_STAT3 ATG12_ID2_MMP9_BHLHE41
DIABLO_BECN1 ATG12_DIABLO_MMP9 ATG12_BNIP3_ID2_MMP9
ATG12_LAMP1 ATG12_FAS_RPS19BP1 DIABLO_FAS_SATB1_STAT3
ATG12_LC3 DIABLO_FAS_MMP9 DIABLO_FAS_NAMPT_RPS19BP1
DIABLO_TCF3 ID2_MMP9_NAMPT ATG12_ATG3_ID2_MMP9
AKT1_ATG12 ATG12_ID2_STAT3 ATG12_ID2_MMP9_NAMPT
ATG12_FRAP1 ATG12_DIABLO_TCF3 DIABLO_FAS_NAMPT_SESN2
DIABLO_ID2 ATG12_ATG3_ID2 DIABLO_ID2_NAMPT_SESN2
ID2_TCF3 ATG12_DIABLO_ID2 ATG12_ID2_TCF3_RPS19BP1
DIABLO_SATB1 CSE1L_DIABLO_STAT3 ATG12_DIABLO_MMP9_TCF3
ATG12_BECN1 DIABLO_ID2_STAT3 ATG12_CSE1L_ID2_SATB1
ATG12_SIRT1 ATG12_ATG3_RPS19BP1 ATG12_FAS_MMP9_RPS19BP1
NAMPT_STAT3 ATG12_DIABLO_SATB1 ID2_MMP9_TCF3_STAT3
ATG12_BNIP3 ATG12_MMP9_TCF3 ATG12_DIABLO_ID2_NAMPT
DIABLO_MMP9 ATG3_DIABLO_NAMPT DIABLO_ID2_TCF3_STAT3
ATG12_UVRAG ATG12_DIABLO_NAMPT ATG12_ULK1_ID2_TCF3
DIABLO_FRAP1 ATG12_CSE1L_RPS19BP1 ATG12_ID2_TCF3_SESN2
NAMPT_RPS19BP1 DIABLO_MMP9_NAMPT BNIP3_CSE1L_DIABLO_MMP9
AKT1_NAMPT ATG12_ATG3_DIABLO ATG12_DIABLO_ID2_TCF3
E2F1_UVRAG DIABLO_SATB1_STAT3 ATG12_ATG5_ID2_MMP9
ATG3_DIABLO ID2_TCF3_STAT3 ATG12_ID2_SATB1_STAT3
NAMPT_UVRAG ATG12_RPS19BP1_SATB1 ATG12_MMP9_TCF3_RPS19BP1
BNIP3_DIABLO ATG12_DIABLO_STAT3 ATG12_DIABLO_FAS_ID2
DIABLO_LC3 ATG12_TCF3_RPS19BP1 ATG12_CSE1L_ID2_SESN2
DIABLO_SIRT1 DIABLO_NAMPT_SESN2 DIABLO_FAS_MMP9_TCF3
LC3_NAMPT ATG12_DIABLO_SESN2 ATG12_ID2_TCF3_BHLHE41
DIABLO_SESN2 ATG12_ULK1_ID2 ATG12_FAS_ID2_STAT3
FAS_STAT3 ATG12_ATG5_ID2 BNIP3_CSE1L_ID2_MMP9
FAS_NAMPT AKT1_DIABLO_NAMPT CSE1L_DIABLO_FAS_NAMPT
E2F1_NAMPT ATG12_ID2_BECN1 ATG12_CSE1L_ID2_TCF3
ATG12_SESN3 ATG12_FAS_MMP9 ATG12_ID2_NAMPT_RPS19BP1
BCL2_TKT ATG12_DIABLO_BHLHE41 ATG12_ID2_MMP9_BECN1
ATG7_NAMPT ATG12_RPS19BP1_STAT3 DIABLO_FAS_LC3_NAMPT
ATG7_BECN1 DIABLO_NAMPT_RPS19BP1 FAS_ID2_NAMPT_RPS19BP1
CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
DIABLO_FAS_ID2_MMP9_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_NAMPT
ATG12_ATG3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3
ATG12_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1
ATG12_CSE1L_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_TCF3_SATB1
ATG12_BNIP3_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1
ATG12_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3
ATG12_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2
ATG12_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_STAT3
ATG12_FAS_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_SESN2
ATG12_ID2_MMP9_TCF3_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3
ATG12_BNIP3_ID2_MMP9_RPS19BP1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3
ATG12_CSE1L_ID2_MMP9_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1
ATG12_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2
DIABLO_FAS_ID2_NAMPT_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_MMP9_TCF3_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_STAT3
ATG12_BNIP3_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BHLHE41 ATG12_ATG3_BNIP3_ID2_MMP9_SATB1
ATG12_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1
ATG12_BNIP3_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9
ATG12_BNIP3_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1
ATG12_ATG3_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SATB1
CSE1L_DIABLO_ID2_MMP9_NAMPT ATG12_CSE1L_ULK1_ID2_MMP9_TCF3
ATG12_DIABLO_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1
DIABLO_ID2_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_NAMPT_SATB1_STAT3
ATG12_ATG3_CSE1L_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3
ATG12_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_ID2_MMP9_TCF3_SESN2
ATG12_DIABLO_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SESN2
DIABLO_FAS_ID2_MMP9_STAT3 ATG12_ID2_MMP9_TCF3_SATB1_SESN2
ATG12_CSE1L_ID2_MMP9_BHLHE41 ATG12_ULK1_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_MMP9_NAMPT_STAT3 ATG12_ATG3_ATG5_ID2_MMP9_TCF3
DIABLO_FAS_ID2_NAMPT_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9
ATG12_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_LAMP1_ID2_MMP9_TCF3
DIABLO_FAS_ID2_TCF3_NAMPT ATG12_BNIP3_DIABLO_ID2_MMP9_TCF3
ATG12_ATG3_ID2_MMP9_SATB1 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_ID2_MMP9_BHLHE41 ATG12_DIABLO_FAS_ID2_MMP9_TCF3
ATG3_DIABLO_FAS_ID2_NAMPT ATG12_ULK1_ID2_MMP9_TCF3_SESN2
CSE1L_DIABLO_FAS_ID2_NAMPT ATG3_DIABLO_FAS_ID2_MMP9_NAMPT
ATG12_CSE1L_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_ID2_MMP9_SESN2
ATG12_CSE1L_ULK1_ID2_MMP9 ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41
DIABLO_FAS_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9
CSE1L_DIABLO_ID2_NAMPT_STAT3 DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1
ATG12_ATG3_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1
DIABLO_ID2_MMP9_TCF3_STAT3 ATG12_ATG5_ID2_MMP9_TCF3_SATB1
DIABLO_ID2_TCF3_NAMPT_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3
CSE1L_DIABLO_FAS_MMP9_NAMPT ATG12_ATG3_CSE1L_ID2_MMP9_SATB1
DIABLO_FAS_ID2_NAMPT_RPS19BP1 ATG12_ATG3_ID2_MMP9_TCF3_STAT3
BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_SATB1
DIABLO_ID2_MMP9_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41
ATG12_DIABLO_FAS_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_SESN2
ATG12_ATG5_FAS_ID2_MMP9 DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1
ATG12_LC3_ID2_MMP9_TCF3 ATG12_ATG3_CSE1L_ID2_MMP9_SESN2
ATG12_FAS_ID2_MMP9_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1
FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_ATG5_BNIP3_FAS_ID2_MMP9
ATG12_ID2_MMP9_TCF3_BECN1 ATG12_ATG5_ULK1_ID2_MMP9_TCF3
ATG12_CDH1_ID2_MMP9_TCF3 E2F1_FAS_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3
DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2
DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1
ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2
ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3 ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2
ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9
ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_BHLHE41
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1
ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2
DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1
ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1
ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2
ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2
ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1
CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1
ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3
ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3
ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2
ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3
ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1
ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2
ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1
ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2
ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1
ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3
ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2
ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2
ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2
ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_TCF3
ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2
ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1
ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3
ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3
DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9
CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41
DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3
CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1
ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1
ATG12_ATG3_BNIP3_FAS_ID2MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2
ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG
优选的是，所述组合物或试剂盒用于预测B组的无病存活预后，并且所述基因是选自下表12所示的基因或基因的组中的一种或多种。
[表12]
一种 两种的组合 三种的组合 四种的组合
DIABLO ATG3_BECN1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1
BECN1 ATG3_HMGB1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
HMGB1 BCL2L1_TKT ATG3_HMGB1_UVRAG ATG3_BCL2_TKT_HMGB1
CSE1L_DIABLO ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_RAGE
BCL2_HMGB1 ATG3_HMGB1_SIRT1 ATG3_BCL2_HMGB1_HMGB2
ATG12_ATG3 ATG3_BECN1_SATB1 ATG3_CDH1_HMGB1_SIRT1
ATG3_NAMPT ATG3_HMGB1_LAMP2 ATG3_BCL2_HMGB1_MMP2
HMGB1_TWIST1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_HMGB2_RAGE
TKT_HMGB1 ATG3_LC3_BECN1 ATG3_BCL2_BNIP3_HMGB1
LAMP1_HMGB1 ATG3_HMGB1_KIAA1967 ATG3_CDH1_CASP3_HMGB1
TKT_BECN1 BCL2L1_TKT_CASP3 ATG3_CDH1_HMGB1_KIAA1967
HMGB1_TP63 ATG12_ATG3_HMGB1 ATG3_HMGB1_RAGE_UVRAG
BCL2_TKT BCL2L1_TKT_SIRT1 ATG3_HMGB1_RAGE_SIRT1
TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_TKT_HMGB1_UVRAG
FASLG_HMGB1 BCL2_TKT_HMGB1 ATG3_BCL2_LAMP1_HMGB1
TKT_NAMPT ATG3_BECN1_SESN3 ATG3_BCL2_HMGB1_RAPTOR
ATG5_HMGB1 ATG3_BNIP3_HMGB1 AIFM1_ATG3_BCL2_HMGB1
HMGB1_SIRT1 ATG3_BECN1_HMGB1 ATG3_CASP3_HMGB1_RAGE
ATG12_HMGB1 AIFM1_ATG3_HMGB1 ATG12_ATG3_HMGB1_RAGE
HMGB1_RAGE ATG3_LAMP1_HMGB1 ATG3_TKT_CASP3_HMGB1
DIABLO_NAMPT BCL2L1_TKT_FASLG ATG3_TKT_HMGB1_KIAA1967
HMGB1_UVRAG BCL2_BCL2L1_TKT ATG3_BCL2L1_TKT_BECN1
DIABLO_BECN1 TKT_HMGB1_TWIST1 ATG12_ATG3_CDH1_HMGB1
BECN1_SATB1 ATG3_NNMT_HMGB1 ATG3_CDH1_HMGB1_RAGE
BCL2L1_SIRT1 BCL2L1_TKT_HMGB1 ATG3_BCL2_FRAP1_HMGB1
BCL2L1_HMGB1 ATG3_BCL2L1_BECN1 ATG3_BCL2_HMGB1_LAMP2
TKT_SIRT1 ATG5_TKT_HMGB1 ATG3_BCL2_DIABLO_HMGB1
DIABLO_TCF3 ATG3_FASLG_HMGB1 ATG3_TKT_HMGB1_SIRT1
HMGB1_LAMP2 ATG3_MMP9_BECN1 ATG3_BCL2_CBS_HMGB1
DIABLO_SATB1 ATG3_LAMP1_BECN1 ATG3_BCL2_CASP8_HMGB1
HMGB1_RAPTOR ATG3_E2F1_HMGB1 ATG3_BCL2_PTEN_HMGB1
E2F1_HMGB1 HMGB1_RAPTOR_TWIST1 ATG3_HMGB1_RAGE_RAPTOR
ATG5_BECN1 AKT1_ATG3_BECN1 ATG3_TKT_HMGB1_RAGE
ATG12_SATB1 ATG3_ULK1_HMGB1 ATG3_BCL2_CASP3_HMGB1
BCL2L1_BECN1 TKT_HMGB1_SIRT1 ATG3_BCL2_HMGB1_SATB1
CASP3_HMGB1 ATG3_BAX_HMGB1 ATG3_HMGB1_LAMP2_RAGE
ATG12_CSE1L ATG3_PTEN_HMGB1 ATG3_CDH1_HMGB1_LAMP2
ATG7_HMGB1 ATG3_TKT_HMGB1 ATG3_HMGB1_HMGB2_UVRAG
ATG3_SIRT1 ATG3_TKT_BECN1 ATG3_BCL2L1_TKT_HMGB1
CASP8_HMGB1 ATG3_HMGB1_TWIST1 CDH1_HMGB1_TP63_UVRAG
ATG3_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2L1_TKT_CASP3
TKT_KIAA1967 TKT_HMGB1_UVRAG ATG3_HMGB1_KIAA1967_RAGE
ATG12_BCL2L1 BCL2L1_TKT_CDH2 ATG3_BCL2_DRAM_HMGB1
DRAM_HMGB1 BCL2L1_TKT_KIAA1967 ATG3_BCL2_HMGB1_UVRAG
LC3_FASLG ATG3_BCL2L1_HMGB1 BCL2_BCL2L1_TKT_CASP3
HMGB1_KIAA1967 ATG3_ATG5_HMGB1 ATG3_TKT_BECN1_HMGB1
TKT_SESN1 ATG3_DRAM_HMGB1 ATG3_TKT_HMGB1_LAMP2
ATG3_DIABLO ATG3_HMGB1_SATB1 ATG3_BCL2_PRKAA1_HMGB1
DIABLO_SIRT1 ATG3_BCL2L1_TKT BCL2L1_TKT_CASP3_SIRT1
BECN1_HMGB1 ATG3_PRKAA1_HMGB1 BCL2L1_TKT_CASP3_FASLG
AIFM1_HMGB1 TKT_CASP3_HMGB1 BCL2L1_TKT_CASP3_CDH2
ID2_BECN1 ATG3_XIAP_HMGB1 ATG3_BCL2_NNMT_HMGB1
CSE1L_BECN1 TKT_HMGB1_KIAA1967 ATG3_CDH1_HMGB1_RAPTOR
TKT_ULK1 TKT_HMGB1_LAMP2 ATG3_BNIP3_HMGB1_RAGE
BNIP3_HMGB1 HMGB1_RAGE_TWIST1 ATG3_BAX_BCL2_HMGB1
TKT_UVRAG ATG12_BCL2L1_TKT ATG3_BCL2_ID2_HMGB1
ATG5_TKT ATG3_PTEN_BECN1 ATG3_BCL2_HMGB1_STAT3
五种的组合 六种的组合
ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE
ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG
ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE
ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG
ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE
ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2
ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1
ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG
ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2
ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR
ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1
ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2
ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE
ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE
ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1
ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG
ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1
ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG
ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1
ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1
ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE
ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967
ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR
AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG
ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE
ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG
ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG
ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR
ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR
ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3
ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG
ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2
ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1
ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1
ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2
ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG
ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG
CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2
ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967
ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE
ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2CDH2_HMGB2_KIAA1967_TWIST1
ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2
ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2CASP3_HMGB2_UVRAG
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1
ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3TKT_ID2_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1
ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE
ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3TKT_ID2CASP3_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE
AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1
ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG
ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG
ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967
AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3TKT_HMGB1_RAGE_RAPTOR_TTWIST1_UVRAG
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3TKT_ID2_CASP3_SIRT1
ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG
ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1
ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1
ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967
AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR
ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE
ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR
ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG
ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1
ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG
ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR
ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE
NNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG
优选的是，所述组合物或试剂盒用于预测C组的复发预后，并且所述基因是选自下表13所示的基因或基因的组中的一种或多种。
[表13]
一种 两种的组合 三种的组合 四种的组合
FASLG CIAP2_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 E2F1_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
CSE1L LC3_FASLG E2F1_LC3_FASLG BNIP3_FAS_LC3_FASLG
FAS DIABLO_FASLG FAS_FASLG_RPS19BP1 DRAM_FAS_LC3_FASLG
TCF3 FAS_FASLG E2F1_FAS_FASLG E2F1_FAS_LC3_FASLG
FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG3_FAS_LC3_FASLG
PTEN_FASLG DIABLO_LC3_FASLG ATG7_FAS_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_LC3_FASLG_STAT3
FASLG_SESN2 CIAP2_FASLG_SESN3 FAS_FRAP1_LC3_FASLG
FASLG_HMGB1 CIAP2_FASLG_UVRAG FAS_LC3_FASLG_SESN3
CDH2_FASLG BNIP3_LC3_FASLG FAS_LC3_FASLG_SIRT1
FRAP1_FASLG LC3_CIAP2_FASLG FAS_LC3_BECN1_FASLG
ATG7_FASLG LC3_FASLG_SESN2 ATG5_FAS_LC3_FASLG
ATG3_FAS FRAP1_LC3_FASLG FAS_LC3_FASLG_RPS19BP1
FASLG_HMGB2 LC3_FASLG_SESN3 FAS_LAMP1_LC3_FASLG
FASLG_UVRAG ATG3_FAS_FASLG FAS_LC3_FASLG_NAMPT
DIABLO_FAS ATG7_LC3_FASLG AKT1_FAS_LC3_FASLG
FASLG_MMP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_SESN2
TKT_FASLG DIABLO_FASLG_SESN2 FAS_LC3_MMP9_FASLG
PTEN_CIAP2 DRAM_LC3_FASLG FAS_FASLG_RPS19BP1_SESN3
FAS_LC3 CIAP2_FASLG_HMGB1 FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG FAS_FASLG_SESN3 FAS_LC3_CDH1_FASLG
AIFM1_FASLG LC3_FASLG_UVRAG ATG12_FAS_LC3_FASLG
CASP3_CIAP2 CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_SESN3
FASLG_SESN3 FAS_FASLG_SESN2 DIABLO_FAS_FASLG_UVRAG
ATG3_FASLG PTEN_CIAP2_FASLG FAS_LC3_FASLG_LAMP2
CASP8_FASLG DIABLO_FASLG_SESN3 FAS_LC3_ID2_FASLG
XIAP_FASLG ATG7_CIAP2_FASLG DIABLO_FAS_FASLG_SESN2
AGER_FASLG LC3_FASLG_SIRT1 FAS_LC3_BHLHE41_FASLG
ATG3_ULK1 LC3_FASLG_RPS19BP1 DIABLO_DRAM_FAS_FASLG
BNIP3_FASLG FASLG_SESN2_SESN3 DIABLO_FAS_FASLG_STAT3
FAS_UVRAG DRAM_FAS_FASLG DRAM_FAS_FASLG_RPS19BP1
CIAP2_RAGE ID2_CIAP2_FASLG DIABLO_FAS_FRAP1_FASLG
ATG3_TCF3 FAS_FASLG_STAT3 FAS_FASLG_SESN2_UVRAG
FASLG_RAGE AKT1_CIAP2_FASLG ATG3_FAS_FASLG_SESN2
E2F1_CIAP2 DIABLO_FRAP1_FASLG ATG7_DIABLO_FAS_FASLG
FASLG_VEGF BNIP3_FAS_FASLG FAS_LC3_TCF3_FASLG
E2F1_FAS FAS_LAMP1_FASLG ATG7_FAS_FASLG_UVRAG
XIAP_CIAP2 TKT_CIAP2_FASLG DIABLO_FAS_FASLG_NAMPT
BCL2L1_FASLG ATG7_DIABLO_FASLG DIABLO_FAS_FASLG_SIRT1
BNIP3_FAS FRAP1_FASLG_SESN2 DIABLO_FAS_LAMP1_FASLG
FASLG_SESN1 E2F1_ULK1_FASLG FAS_FRAP1_FASLG_RPS19BP1
FASLG_KIAA1967 DRAM_CIAP2_FASLG CSE1L_FAS_LC3_FASLG
AIFM1_CIAP2 PTEN_CASP3_FASLG DIABLO_FAS_BECN1_FASLG
DRAM_FASLG LC3_FASLG_NAMPT E2F1_LC3_ID2_FASLG
ATG3_CIAP2 PTEN_CDH1_CIAP2 AKT1_DIABLO_FAS_FASLG
CSE1L_FASLG ATG12_CIAP2_FASLG ATG3_DIABLO_FAS_FASLG
FASLG_RAPTOR FASLG_RPS19BP1_SESN3 E2F1_FAS_FASLG_SESN3
TCF3_FASLG MMP9_CIAP2_FASLG ATG7_FAS_FASLG_SESN2
FASLG_STAT3 LAMP1_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
ULK1_FASLG LC3_BECN1_FASLG DRAM_FAS_FASLG_UVRAG
PRKAA1_CIAP2 CDH1_CIAP2_FASLG LC3_MMP9_FASLG_SESN2
FASLG_SIRT1 BECN1_CIAP2_FASLG FAS_FASLG_SESN3_UVRAG
ATG12_FASLG CIAP2_FASLG_HMGB2 DIABLO_FAS_FASLG_LAMP2
LAM P1_FASLG E2F1_FASLG_LAMP2 DIABLO_FAS_ID2_FASLG
NNMT_FASLG CIAP2_FASLG_SIRT1 E2F1_LC3_FASLG_LAMP2
BCL2L1_CIAP2 PTEN_XIAP_FASLG E2F1_LC3_MMP9_FASLG
CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG
ATG3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SIRT1
DIABLO_FAS_LC3_BECN1_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN2
BNIP3_DIABLO_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_BECN1_FASLG
ATG7_DRAM_FAS_LC3_FASLG DRAM_FAS_LC3_ID2_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SIRT1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
DRAM_FAS_LC3_BECN1_FASLG DRAM_FAS_LC3_MMP9_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_ID2_FASLG
BNIP3_FAS_LC3_MMP9_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN3
DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG5_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
ATG5_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_FASLG_SESN3_SIRT1
FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BHLHE41_FASLG_UVRAG
DRAM_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_DRAM_FAS_LC3_FASLG
FAS_LC3_BECN1_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
ATG3_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN3_SIRT1
BNIP3_FAS_LC3_FASLG_SIRT1 ATG3_DIABLO_FAS_LC3_MMP9_FASLG
BNIP3_FAS_FRAP1_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN3_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_BECN1_FASLG_SESN2
DIABLO_FAS_LC3_FASLG_NAMPT BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
FAS_LC3_MMP9_FASLG_RPS19BP1 DIABLO_DRAM_FAS_LC3_MMP9_FASLG
BNIP3_FAS_LC3_BECN1_FASLG BNIP3_FAS_LC3_BECN1_FASLG_SESN3
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
ATG3_DIABLO_FAS_LC3_FASLG ATG3_FAS_FRAP1_LC3_MMP9_FASLG
DIABLO_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_BECN1_FASLG_SESN3
FAS_LC3_ID2_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_DRAM_FAS_LC3_MMP9_FASLG
DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG
DRAM_FAS_LAMP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
ATG3_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG
FAS_LC3_FASLG_STAT3_UVRAG ATG5_DRAM_FAS_LC3_FASLG_SESN3
AKT1_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_STAT3
FAS_LC3_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
ATG3_DRAM_FAS_LC3_FASLG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
AKT1_DRAM_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_SESN2
FAS_LC3_FASLG_SESN2_UVRAG ATG5_FAS_LC3_MMP9_FASLG_UVRAG
FAS_LC3_BHLHE41_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BHLHE41_FASLG
DRAM_FAS_LC3_FASLG_NAMPT DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG_SESN3
ATG7_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_TCF3_FASLG_UVRAG
AKT1_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
E2F1_FAS_LC3_ID2_FASLG ATG5_DRAM_FAS_LC3_FASLG_STAT3
DRAM_FAS_LC3_CDH1_FASLG ATG7_DRAM_FAS_LC3_MMP9_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合 八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2
ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3
ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3
ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3
BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3
ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2
ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1
BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2
ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN3
BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2
ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_FASLG
BNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG BNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3
ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3
BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1
FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG
优选的是，所述组合物或试剂盒用于预测C组的存活预后，并且所述基因是选自下表14所示的基因或基因的组中的一种或多种。
[表14]
一种 两种的组合 三种的组合 四种的组合
CSE1L ID2_CIAP2 ID2_CIAP2_SESN2 AIFM1_ID2_CIAP2_SESN2
CIAP2 CASP3_CIAP2 ID2_CASP3_CIAP2 PTEN_ID2_CIAP2_SESN2
TCF3 ID2_TCF3 ULK1_ID2_HMGB2 DIABLO_ID2_CASP3_CIAP2
CDH2 DIABLO_CDH2 ULK1_ID2_HMGB1 DRAM_FRAP1_CIAP2_TP63
FASLG CSE1L_CDH2 DIABLO_ID2_CASP3 BAX_ID2_CIAP2_SESN2
BECN1 CSE1L_TCF3 ULK1_ID2_AGER ID2_CIAP2_SESN2_VEGF
CASP3 CSE1L_CASP3 ID2_CIAP2_RPS19BP1 DRAM_ID2_CIAP2_SESN2
CDH1 CSE1L_RPS19BP1 CASP8_ULK1_ID2 ID2_CIAP2_RPS19BP1_SESN2
CDH2_CIAP2 ID2_TCF3_CIAP2 CBS_ID2_CIAP2_SESN2
ULK1_ID2 FRAP1_ID2_CIAP2 ATG3_ID2_CIAP2_SESN2
CSE1L_ID2 AIFM1_CDH1_CIAP2 NNMT_ID2_CIAP2_SESN2
CDH1_CIAP2 PTEN_CDH1_CIAP2 DIABLO_ID2_CIAP2_SESN2
CSE1L_FASLG ULK1_ID2_CIAP2 PRKAA1_ID2_CIAP2_SESN2
NNMT_CIAP2 DIABLO_ID2_CDH2 FRAP1_ID2_CIAP2_SESN2
CSE1L_MMP9 CDH1_CIAP2_VEGF DIABLO_DRAM_ID2_CASP3
CSE1L_CDH1 CDH1_CCNG2_CIAP2 XIAP_ID2_CIAP2_SESN2
CIAP2_RPS19BP1 BAX_CDH1_CIAP2 ID2_CIAP2_RAGE_SESN2
ID2_CDH2 ATG3_ID2_TCF3 DRAM_CIAP2_SESN2_TP63
CDH2_RPS19BP1 ULK1_ID2_MMP2 BNIP3_ID2_CIAP2_SESN2
CSE1L_STAT3 CBS_ULK1_ID2 BCL2L1_ID2_CIAP2_SESN2
DIABLO_CASP3 DIABLO_ID2_CIAP2 AIFM1_DIABLO_CDH1_CIAP2
CDH1_TCF3 LC3_ID2_CIAP2 ID2_CCNG2_CIAP2_SESN2
CSE1L_SIRT1 PTEN_ULK1_ID2 LC3_ID2_CIAP2_SESN2
CIAP2_SESN2 BAX_ULK1_ID2 ID2_CASP3_CIAP2_RPS19BP1
AIFM1_CIAP2 DIABLO_PTEN_CDH1 AIFM1_CDH1_CIAP2_SESN2
DIABLO_KIAA1967 CDH1_CASP3_CIAP2 ATG3_ID2_TCF3_RPS19BP1
CSE1L_KIAA1967 ULK1_ID2_CDH2 DIABLO_FRAP1_ID2_CDH2
AKT1_CSE1L CDH1_CIAP2_RAGE E2F1_ID2_CIAP2_SESN2
CSE1L_SESN2 ID2_CDH2_CIAP2 ID2_CASP3_CIAP2_SESN2
FRAP1_CDH2 NNMT_ID2_CIAP2 DRAM_ID2_CIAP2_RPS19BP1
FRAP1_CIAP2 XIAP_CIAP2_SESN2 ID2_CIAP2_HMGB1_SESN2
TCF3_FASLG CSE1L_ID2_CASP3 PTEN_ID2_CASP3_CIAP2
FASLG_SESN2 CSE1L_FRAP1_CDH2 ATG3_ID2_MMP9_TCF3
CSE1L_DIABLO BCL2_ID2_SESN2 LAMP1_ID2_CIAP2_SESN2
CSE1L_SATB1 AIFM1_ULK1_ID2 AIFM1_ID2_CASP3_CIAP2
MMP9_TCF3 ULK1_ID2_RAGE ATG5_ID2_CIAP2_SESN2
ATG12_CSE1L DIABLO_CDH1_CCNG2 DIABLO_PTEN_CDH1_CIAP2
ATG7_CSE1L BAX_DIABLO_CDH1 LAMP1_ID2_CASP3_CIAP2
CSE1L_BECN1 CSE1L_ID2_CDH2 ID2_CIAP2_HMGB2_SESN2
XIAP_CIAP2 AIFM1_CIAP2_SESN2 BCL2L1_CSE1L_ID2_SESN2
CSE1L_FAS NNMT_CDH1_CIAP2 TKT_ID2_CIAP2_SESN2
TCF3_RPS19BP1 CBS_ID2_CIAP2 DIABLO_XIAP_ID2_SESN2
XIAP_SESN2 DIABLO_CDH1_VEGF FRAP1_LC3_ID2_CIAP2
CIAP2_KIAA1967 ID2_MMP9_TCF3 ATG7_ID2_CIAP2_SESN2
TKT_CIAP2 AIFM1_DIABLO_CDH1 ID2_AGER_CIAP2_SESN2
PRKAA1_CIAP2 PRKAA1_CIAP2_SESN2 CSE1L_ID2_CASP3_CIAP2
CDH2_FASLG CDH1_ID2_CIAP2 DRAM_CASP3_CIAP2_TP63
CSE1L_FRAP1 CSE1L_CASP3_CIAP2 PTEN_CDH1_ID2_CIAP2
CSE1L_CIAP2 ULK1_ID2_VEGF CDH1_ID2_CIAP2_RPS19BP1
CSE1L_ULK1 ID2_CIAP2_HMGB1 ATG3_ULK1_ID2_HMGB1
PTEN_CIAP2 BCL2L1_CDH1_CIAP2 FRAP1_ID2_CIAP2_RPS19BP1
BCL2L1_CIAP2 ID2_CIAP2_MMP2 DIABLO_PTEN_ID2_CASP3
CIAP2_VEGF CSE1L_ID2_CIAP2 ID2_CIAP2_SESN2_TP63
ATG3_TCF3 BCL2L1_CSE1L_CDH1 ID2_TCF3_CIAP2_SESN2
AKT1_TCF3 CSE1L_CDH1_CASP3 DIABLO_CDH1_CIAP2_VEGF
CSE1L_LC3 CSE1L_XIAP_SESN2 ATG3_ULK1_ID2_AGER
TKT_CDH2 PRKAA1_CDH1_CIAP2 ID2_CIAP2_MMP2_SESN2
CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63
DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63
ATG12_DRAM_FRAP1_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_XIAP_CIAP2_TP63 DRAM_TKT_ID2_CIAP2_SESN2_TP63
DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63
AIFM1_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_CDH1_CIAP2_TP63
AIFM1_DRAM_FRAP1_CIAP2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_PTEN_ID2_CIAP2_SESN2_TP63
PTEN_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
BAX_CDH1_ID2_CIAP2_SESN2 DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63
DRAM_FRAP1_ID2_CIAP2_TP63 ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63
DRAM_TKT_CASP3_CIAP2_TP63 ATG7_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CCNG2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_PTEN_ID2_CIAP2_SESN2 ATG5_DRAM_ID2_CIAP2_SESN2_TP63
DIABLO_FRAP1_CDH1_ID2_CIAP2 AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2
AIFM1_CBS_ID2_CIAP2_SESN2 AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63
AIFM1_LAMP1_ID2_CIAP2_SESN2 BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_ID2_CASP3_CIAP2_TP63 DRAM_NNMT_ID2_CIAP2_SESN2_TP63
DIABLO_PTEN_CDH1_ID2_CIAP2 CASP8_DRAM_ID2_CIAP2_SESN2_TP63
CDH1_ID2_CIAP2_SESN2_VEGF DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CASP3_CIAP2 DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63
AIFM1_ATG3_ID2_CIAP2_SESN2 DRAM_LAMP1_ID2_CIAP2_SESN2_TP63
AIFM1_BNIP3_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_ID2_CIAP2_TP63
AIFM1_DIABLO_CDH1_ID2_CIAP2 BNIP3_DRAM_ID2_CIAP2_SESN2_TP63
ATG3_DRAM_ID2_CIAP2_SESN2 DRAM_ID2_MMP9_CIAP2_SESN2_TP63
AIFM1_BAX_ID2_CIAP2_SESN2 AKT1_DRAM_ID2_CIAP2_SESN2_TP63
DRAM_E2F1_CASP3_CIAP2_TP63 DRAM_ID2_CIAP2_RAGE_SESN2_TP63
AIFM1_ID2_CIAP2_HMGB2_SESN2 ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63
AIFM1_ID2_MMP9_CIAP2_SESN2 DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63
DIABLO_CDH1_ID2_CIAP2_VEGF DRAM_XIAP_ID2_CIAP2_SESN2_TP63
DIABLO_DRAM_XIAP_ID2_SESN2 AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63
AIFM1_ATG5_ID2_CIAP2_SESN2 ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63
AIFM1_ID2_CIAP2_HMGB1_SESN2 CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63
BAX_DIABLO_CDH1_ID2_CIAP2 AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63
DRAM_FRAP1_NNMT_CIAP2_TP63 AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63
FRAP1_CDH1_ID2_CIAP2_RPS19BP1 BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
DRAM_XIAP_CIAP2_SESN2_TP63 CBS_DRAM_ID2_CIAP2_SESN2_TP63
AIFM1_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_NNMT_TKT_CIAP2_TP63
AIFM1_DRAM_ID2_CIAP2_SESN2 AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63
AIFM1_ID2_CIAP2_SESN2_VEGF DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63
AIFM1_TKT_ID2_CIAP2_SESN2 DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2
ATG3_ID2_MMP9_TCF3_RPS19BP1 DRAM_ID2_CIAP2_SESN2_TP63_VEGF
ATG5_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63
CBS_FRAP1_ID2_CIAP2_SESN2 BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_DIABLO_ID2_CASP3_CIAP2 AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63
AIFM1_NNMT_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63
ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63
ATG3_FRAP1_ID2_CIAP2_SESN2 AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63
BAX_DIABLO_DRAM_ID2_CASP3 AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63
LAMP1_PTEN_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63
CDH1_ID2_CIAP2_RAGE_SESN2 AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63
CBS_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_CIAP2_TP63_VEGF
DIABLO_CDH1_ID2_CCNG2_CIAP2 AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63
DIABLO_LAMP1_ID2_CASP3_CIAP2 DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2
AIFM1_DRAM_CASP3_CIAP2_TP63 DRAM_TKT_XIAP_CIAP2_SESN2_TP63
BCL2L1_DRAM_FRAP1_CIAP2_TP63 AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63
CDH1_ID2_MMP9_TCF3_CIAP2 BAX_CDH1_ID2_MMP9_TCF3_CIAP2
七种的组合 八种的组合
AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63
ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF
ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63
ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63
AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63
AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF
AIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63
AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63
ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63
ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63
AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63
AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63
AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGF
AIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63
AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGF
DRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63
AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63
AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63
AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63
ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63
AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63
AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF
DRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 AIFM1_ATG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63
BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_DRAM_NNMT_PTEN_ID2_CIAP2_SESN2_TP63
AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63
AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63
AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63
ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63
AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63
AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63
AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63
AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63
AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63
AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF
AIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63
AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63
ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63
BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63
BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63
CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER
优选的是，所述组合物或试剂盒用于预测C组的无病存活预后，并且所述基因是选自下表15所示的基因或基因的组中的一种或多种。
[表15]
一种 两种的组合 三种的组合 四种的组合
FASLG FAS_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG
CIAP2 LC3_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG
FAS E2F1_FASLG E2F1_LC3_FASLG E2F1_FAS_LC3_FASLG
CSE1L CIAP2_FASLG FAS_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG
TCF3 DIABLO_FASLG E2F1_FAS_FASLG DRAM_FAS_LC3_FASLG
FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG7_FAS_LC3_FASLG
FASLG_SESN2 DIABLO_LC3_FASLG FAS_LAMP1_LC3_FASLG
CASP3_FASLG ATG7_FAS_FASLG FAS_FRAP1_LC3_FASLG
FASLG_UVRAG FAS_FASLG_SESN2 ATG3_FAS_LC3_FASLG
FRAP1_FASLG LC3_FASLG_SESN2 FAS_LC3_FASLG_RPS19BP1
PTEN_FASLG FAS_LAMP1_FASLG FAS_LC3_FASLG_SESN3
FASLG_HMGB1 ATG3_FAS_FASLG FAS_LC3_FASLG_SESN2
ATG3_FAS CIAP2_FASLG_SESN3 ATG5_FAS_LC3_FASLG
CASP3_CIAP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_STAT3
TCF3_FASLG FRAP1_LC3_FASLG FAS_LC3_FASLG_SIRT1
ATG7_FASLG BNIP3_LC3_FASLG AKT1_FAS_LC3_FASLG
PTEN_CIAP2 FAS_FASLG_SESN3 FAS_LC3_ID2_FASLG
CDH2_FASLG BNIP3_FAS_FASLG FAS_LC3_FASLG_NAMPT
FASLG_SESN3 DIABLO_FASLG_SESN2 FAS_LC3_BECN1_FASLG
DIABLO_FAS CIAP2_FASLG_UVRAG FAS_LC3_MMP9_FASLG
FAS_LC3 LC3_FASLG_UVRAG DIABLO_FAS_FASLG_UVRAG
ULK1_FASLG LC3_CIAP2_FASLG ATG12_FAS_LC3_FASLG
CSE1L_FASLG DRAM_FAS_FASLG FAS_FASLG_RPS19BP1_UVRAG
CBS_FASLG LC3_FASLG_SESN3 DIABLO_FAS_FASLG_SESN2
FASLG_HMGB2 FAS_FASLG_STAT3 FAS_LC3_FASLG_LAMP2
FAS_UVRAG ATG7_LC3_FASLG FAS_LC3_CDH1_FASLG
LAMP1_FASLG ATG5_FAS_FASLG DIABLO_FAS_FASLG_SESN3
BNIP3_FASLG E2F1_FASLG_SESN2 FAS_LC3_TCF3_FASLG
MMP9_FASLG LC3_ID2_FASLG E2F1_LC3_ID2_FASLG
TKT_FASLG DRAM_LC3_FASLG FAS_LC3_BHLHE41_FASLG
FASLG_STAT3 FAS_TCF3_FASLG DIABLO_FAS_LAMP1_FASLG
AKT1_FASLG AKT1_FAS_FASLG DIABLO_DRAM_FAS_FASLG
FASLG_MMP2 E2F1_ULK1_FASLG FAS_FASLG_SESN2_UVRAG
DRAM_FASLG E2F1_TCF3_FASLG FAS_FASLG_RPS19BP1_SESN3
FASLG_SIRT1 LC3_FASLG_RPS19BP1 DIABLO_FAS_FRAP1_FASLG
ATG12_FASLG LC3_MMP9_FASLG DIABLO_FAS_FASLG_STAT3
CIAP2_RAGE FAS_FASLG_SIRT1 ATG7_DIABLO_FAS_FASLG
FAS_LAMP1 FAS_ULK1_FASLG CSE1L_FAS_LC3_FASLG
ATG5_FASLG FAS_FASLG_NAMPT E2F1_LC3_MMP9_FASLG
ATG3_FASLG LC3_FASLG_SIRT1 DRAM_FAS_FASLG_RPS19BP1
E2F1_FAS CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1
BECN1_FASLG ATG12_FAS_FASLG FAS_LC3_ULK1_FASLG
E2F1_CIAP2 FAS_BECN1_FASLG DIABLO_FAS_FASLG_SIRT1
CASP8_FASLG ATG5_LC3_FASLG DIABLO_FAS_ID2_FASLG
XIAP_CIAP2 LC3_BECN1_FASLG AKT1_DIABLO_FAS_FASLG
CDH1_FASLG LC3_FASLG_STAT3 DIABLO_FAS_FASLG_NAMPT
FASLG_NAMPT E2F1_FASLG_SESN3 ATG3_FAS_FASLG_SESN2
BNIP3_FAS AKT1_LC3_FASLG FAS_FASLG_RPS19BP1_SESN2
FASLG_LAMP2 FAS_FASLG_LAMP2 DIABLO_FAS_BECN1_FASLG
AGER_FASLG LC3_TCF3_FASLG DIABLO_FAS_CDH1_FASLG
ID2_FASLG LC3_FASLG_NAMPT ATG7_FAS_FASLG_UVRAG
AIFM1_FASLG LC3_CDH1_FASLG DIABLO_FAS_FASLG_LAMP2
FASLG_SESN1 ATG12_LC3_FASLG FAS_FRAP1_FASLG_RPS19BP1
AIFM1_CIAP2 PTEN_CDH1_CIAP2 FAS_LAMP1_FASLG_UVRAG
PRKAA1_CIAP2 LC3_FASLG_LAMP2 E2F1_FAS_LAMP1_FASLG
BCL2L1_CIAP2 DIABLO_FASLG_SESN3 ATG7_FAS_FASLG_RPS19BP1
XIAP_FASLG FAS_CDH1_FASLG E2F1_FAS_FASLG_UVRAG
CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
DIABLO_FAS_LC3_ID2_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2
DRAM_FAS_LC3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG
DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2
BNIP3_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG
BNIP3_DIABLO_FAS_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_STAT3
DIABLO_FAS_LC3_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG
DIABLO_FAS_LC3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN3
DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1
ATG5_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1
BNIP3_FAS_LC3_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2
DIABLO_FAS_LC3_BECN1_FASLG BNIP3_DIABLO_FAS_LC3_ID2_FASLG
DIABLO_FAS_LC3_CDH1_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2
ATG3_FAS_LC3_FASLG_SESN2 DIABLO_FAS_LC3_ID2_FASLG_SIRT1
DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG
DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_FAS_LC3_FASLG_SESN2_SESN3
E2F1_FAS_LC3_ID2_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG
DIABLO_FAS_LC3_FASLG_NAMPT DIABLO_FAS_LC3_ID2_BECN1_FASLG
DIABLO_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SIRT1_UVRAG
FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_ID2_FASLG_SESN2_UVRAG
FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LC3_CDH1_ID2_FASLG
FAS_LAMP1_LC3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1
AKT1_DIABLO_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_SESN3
DIABLO_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_NAMPT
DIABLO_FAS_LC3_BHLHE41_FASLG DIABLO_FAS_LC3_ID2_FASLG_SESN2
FAS_LC3_FASLG_STAT3_UVRAG DIABLO_FAS_LC3_ID2_FASLG_LAMP2
DIABLO_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_SESN2_SIRT1
E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_STAT3
BNIP3_FAS_FRAP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_UVRAG
DIABLO_FAS_LAMP1_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_STAT3
FAS_LC3_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG
AKT1_FAS_LC3_FASLG_UVRAG ATG5_FAS_LC3_ID2_FASLG_UVRAG
BNIP3_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN3_UVRAG
FAS_FRAP1_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG
BNIP3_FAS_LC3_FASLG_STAT3 DIABLO_DRAM_FAS_LC3_CDH1_FASLG
FAS_LC3_CDH1_FASLG_UVRAG AKT1_DIABLO_FAS_LC3_ID2_FASLG
FAS_LC3_FASLG_LAMP2_UVRAG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG
FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_CDH1_FASLG_UVRAG
ATG7_FAS_LC3_FASLG_UVRAG DIABLO_FAS_FRAP1_LC3_ID2_FASLG
ATG7_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_STAT3
BNIP3_FAS_LC3_FASLG_SIRT1 DIABLO_DRAM_FAS_LC3_FASLG_SESN3
DRAM_FAS_LAMP1_LC3_FASLG BNIP3_DIABLO_DRAM_FAS_LC3_FASLG
ATG7_BNIP3_FAS_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_SIRT1
BNIP3_FAS_LAMP1_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG
ATG3_FAS_LC3_MMP9_FASLG DIABLO_DRAM_FAS_LC3_BECN1_FASLG
ATG5_DIABLO_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN3
BNIP3_FAS_LC3_ID2_FASLG DIABLO_FAS_LAMP1_LC3_ID2_FASLG
ATG12_DIABLO_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
E2F1_FAS_LC3_FASLG_SESN3 ATG5_FAS_LC3_FASLG_SESN2_UVRAG
AKT1_BNIP3_FAS_LC3_FASLG FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3
FAS_LC3_FASLG_NAMPT_UVRAG FAS_LAMP1_LC3_ID2_FASLG_UVRAG
ATG12_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG
PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合 八种的组合
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG
BNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2
BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG
FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG
DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG
ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2
BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1
ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3
ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1
BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG
ATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2
ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG
ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2
DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3
FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAG
ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAG
BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2
DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAG
BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2
ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2
DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3
DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAG
DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAG
ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAG
AKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAG
ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3
ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1
BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG
DRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2
ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2
DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2
E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG
本发明的组合物或试剂盒中包含的核酸可以是引物或探针。
这些核酸可以具有诸如DNA和/或RNA等基因的互补序列，或者可以是杂交的。“引物”是指具有游离3′羟基的核酸序列，其能够与模板互补结合，并且使逆转录酶或DNA聚合酶能够引发模板的复制。引物是序列与特定基因的核酸序列互补的核苷酸，可以使用长度为约7bp～50bp、优选为约10bp～30bp的引物。引物可以包含不改变该引物的在DNA合成酶起始点发挥作用的基本特征的其他碱基序列。引物可以使用公知方法以化学手段合成，核酸序列可以使用相关领域中的多种公知手段来转化。
“探针”是指与靶核酸部分互补或完全互补的核酸链，和指能够用碱基特异性方法与靶核酸结合的寡核苷酸。优选的是，探针为与靶核酸完全互补的寡核苷酸。探针不仅包括核酸，而且还包括能够进行互补结合的任何已知的核酸衍生物(包括肽核酸)。探针与靶核酸的结合(通常称之为“杂交”)是序列依赖性的，并且可以在多种条件下进行。通常，杂交反应在特定的离子水平和pH水平下在比特定序列的Tm低约5℃的温度进行。“Tm”是指下述条件：与靶标序列互补的探针已有50％结合到了该序列上。杂交反应条件的实例可以是pH为7.0～8.3且Na+离子浓度为0.01M～1.0M。此外，为了提高靶核酸和探针之间的特异性，该反应可以在不会使靶核酸与探针之间的结合变得不稳定的条件下进行，例如，在温度不高且不存在高浓度的去稳定剂(例如，甲酰胺等)的条件下进行。探针的长度可以是使得探针能够特异性地结合靶核酸的长度，其包括任何长度的多核苷酸。例如，探针的长度可以是10～200个核苷酸、10～150个核苷酸、10～100个核苷酸、10～50个核苷酸或整个基因的长度，但并不限于此。可以用可检测标记来标记探针。可检测标记可以在SYBR Green I或各种探针(TaqMan探针)的5′末端标记有荧光物质FAM，并且在其3′末端标记有淬灭剂TAMRA，但并不限于此。可检测标记包括荧光标记(例如Cy3或Cy5)、放射性物质标记、将底物转化为显色物的酶等，但并不限于此。在本发明的试剂盒中，探针或探针组可以固定在微阵列上。
使样品中的靶核酸与微阵列中的探针杂交，并且可以通过测量杂交结果来测定靶核酸的存在和浓度。可以用可检测标记来标记杂交过程中的靶核酸。
“抗体”是指能够特异性地结合抗原表位的蛋白，该概念包括多克隆抗体、单克隆抗体和重组抗体。抗体可以使用本领域中熟知的技术来容易地制造。具体而言，多克隆抗体可以使用本领域中熟知的下述方法来制造：将由本发明的肝癌预后标志物编码的蛋白抗原注射到动物体内并收集该动物的血液，从而获得包含抗体的血清。这些多克隆抗体可以从多种动物物种宿主制备，例如山羊、兔、绵羊、马、猪、牛和犬等。
单克隆抗体可以使用本领域中熟知的杂交瘤法[Kohler和Milstein(1976)European Journal of Immunology6：511-519]或噬菌体抗体文库技术[Clackson等，Nature，352：624-628，1991；Marks等，J.Mol.Biol.，222：58，1-597，1991]等来制备。
通常，杂交瘤法使用从已经注射了本发明第一方面的肝癌预后标志物所编码的蛋白抗原的免疫学适用宿主动物(例如小鼠)获得的细胞，并使用癌细胞系或骨髓瘤细胞系作为另一群体。使用本领域熟知的方法(例如聚乙二醇)使从这两个群体获得的组织融合，随后使用标准组织培养法使产生抗体的细胞进行增殖。按照有限稀释技术通过亚克隆来获得同源细胞群，随后按照已知的技术在体内或体外大量培养能够产生所需抗体的杂交瘤。噬菌体抗体文库方法是通过下述方式产生单克隆抗体的方法：获得所需抗体的基因，在噬菌体表面将该基因表达为融合蛋白形式，由此在体外产生抗体文库，并将所需的单克隆抗体从该文库中分离出。用上述方法制得的单克隆抗体可以使用已知的方法来分离，例如凝胶电泳、透析、盐析、离子交换色谱和亲和色谱等。
除了由两条全长轻链和两条全长重链组成的完整形状外，抗体还包括抗体分子的功能片段。抗体分子的功能片段是指具有抗原结合功能的片段，包括Fab、F(ab′)、F(ab′)2和Fv等。
对肝癌预后的预测可以是在进行癌症肝脏切除术之前或之后的预后预测。
除了核酸或抗体外，所述试剂盒还可以包含适用于分析基因的表达水平或表达模式的方法或适用于分析蛋白的存在水平或存在模式的方法的一种或多种其他成分、溶液或器件。例如，对于用于检测基因的表达水平或表达模式的诊断试剂盒，该诊断试剂盒可以包含进行RT-PCR所要求的必需成分，而且，根据具体实施方式，除了对标志基因有特异性的各引物之外，该RT-PCR试剂盒可以包含例如试管或其他适当的容器、反应缓冲溶液、脱氧核苷酸(dNTP)、酶(例如Taq聚合酶与逆转录酶)、DNA酶、RNA酶抑制剂、DEPC-水(DEPC水)、无菌水、作为定量对照组使用的基因特异性引物对。同时，对于用于检测蛋白的存在水平或存在模式的试剂盒，该诊断试剂盒可以包含例如进行ELISA所要求的必需成分。该ELISA试剂盒可以包含能够检测到所结合的抗体(例如，带标记的二抗)、生色团、酶(例如，连接在抗体上的酶)及其底物以及对定量对照组的蛋白有特异性的抗体的成分。此外，根据具体实施方式，该试剂盒还可以包含DNA微阵列或蛋白微阵列。
另外，本发明提供一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：对选自表2所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)，或对所述基因编码的蛋白有特异性的抗体。
在该组合物或试剂盒中，基因的组还可包含表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。
除非存在矛盾，针对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒而提及的内容也等同地适用于上述组合物和试剂盒。
此外，本发明提供一种根据分期来预测肝癌预后的方法，所述方法包括：(A)检测获自肝癌患者的样品中的选自由表1所示的基因组成的组的一种或至少两种基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)的表达水平或表达模式中的一项或多项；和(B)将步骤(A)的结果与对照组的测量结果进行比较，从而预测肝癌预后，其中，所述肝癌患者属于选自下述各组中的一个或多个组：A1组{门静脉侵袭阴性患者组，患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤}，A2组{门静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤}，B组{门静脉侵袭阴性患者组，患者处于BCLC分期系统中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤}，或C组{门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何}。
优选的是，上述由基因组成的组可以是由表2所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)组成的组，而且，上述由基因组成的组还可以包含表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。
采集自肝癌患者的样品是指从能够检测到肝癌预后标志物的表达水平或表达模式的人体中或从能够检测到肝癌预后标志物所编码的蛋白的存在水平或存在模式的人体中分离出的细胞和组织等。其实例可以是尿、血液、血浆和血清等，但并不特别限于此。所述组织可以包埋于石蜡块中。
所述基因的表达水平或表达模式可以用一般的生物化学分析方法来检测，这些方法用来确定由对应基因转录产生的mRNA的水平或模式。此类用于确定mRNA的水平或模式的分析方法有RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹和DNA微阵列等。此外，可以使用相关领域中通常使用的任何方法。
通过上述分析方法，肝癌患者的生物样品中的mRNA的水平或模式可以与标准水平进行比较，并可以从中检测出在肝癌预后标志物的表达水平和/或表达模式方面的差异。这使得能够对肝癌患者的预后进行预估。
用于通过RT-PCR来测量mRNA的水平或模式的试剂盒包含对本发明的肝癌预后标志物的mRNA有特异性的引物。根据具体实施方式，RT-PCR试剂盒可以包含试管或其他适当的容器、反应缓冲溶液、脱氧核苷酸(dNTP)、酶(例如Taq聚合酶和逆转录酶)、DNA酶、RNA酶抑制剂、DEPC-水和无菌水等。在适合的缓冲溶液和温度下，引物能够在聚合用试剂(即，DNA聚合酶或逆转录酶)和四种不同的三磷酸核苷的存在下引发DNA的合成。
使用抗体来测量蛋白的表达水平或表达模式的方法有蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS和蛋白芯片等。此外，可以使用相关领域中通常使用的任何方法。
通过上述分析方法，可以将受试肝癌患者的样品中的抗原-抗体复合物的形成水平和形成模式与标准水平进行比较，并可以从中确定出本发明的肝癌预后标志物所编码的蛋白的存在水平或存在模式，并最终能够预估出肝癌患者的预后。此处，“抗原-抗体复合物”是指肝癌预后标志物所编码的蛋白与其特异性抗体的复合物。抗原-抗体复合物的形成水平或形成模式通常可以通过检测与二抗联结的检测标记的信号的大小和模式来测量。此类检测标记的实例可以是酶、荧光物质、配体、发光物质、纳米颗粒、氧化还原分子和放射性同位素等，但并不限于此。当使用酶作为检测标记时，可以使用的酶有β-葡糖醛酸糖苷酶、β-D-葡萄糖苷酶、β-D-半乳糖苷酶、尿素酶、过氧化物酶或碱性磷酸酶、乙酰胆碱酯酶、葡萄糖氧化酶、己糖激酶和GDP酶、RNA酶、葡萄糖氧化酶、荧光素酶、磷酸果糖激酶、磷酸烯醇丙酮酸羧化酶、天冬氨酸氨基转移酶、磷酸烯醇丙酮酸脱羧酶和β-内酰胺酶等，但所述酶并不限于此。当使用荧光物质作为检测标记时，可以使用的荧光物质有荧光素、异硫氰酸酯、罗丹明、藻红蛋白、藻蓝蛋白、别藻蓝蛋白、邻苯二醛和荧光胺等，但所述荧光物质并不限于此。当使用配体作为检测标记时，可以使用的配体有生物素衍生物等，但所述配体并不限于此。当使用发光物质作为检测标记时，可以使用的发光物质有吖啶酯、荧光素和荧光素酶等，但所述发光物质并不限于此。当使用纳米颗粒作为检测标记时，可以使用的纳米颗粒有胶体金和彩色乳胶等，但所述纳米颗粒并不限于此。当使用氧化还原分子作为检测标记时，可以使用的氧化还原分子有二茂铁、钌络合物、紫罗碱、醌、Ti离子、Cs离子、二酰亚胺、1，4-苯醌、氢醌、K4W(CN)8、[Os(bpy)3] 2+、[Ru(bpy)3]2+和[Mo(CN)8]4-等，但所述氧化还原分子并不限于此。当使用放射性同位素作为检测标记时，可以使用的放射性同位素有3H、14C、32P、35S、36Cl、51Cr、57Co、58Co、59Fe、90Y、125I、131I或186Re等，但所述放射性同位素并不限于此。
“测量结果”是指步骤(A)中的从肝癌组织等收集的基因的表达水平或表达模式中的至少一项，“对照组的结果”可以指在通过对从肝癌预后已知的肝癌患者组(A1组、A2组、B组、C组)获得的测量值进行连续变量回归分析而获得的结果中具有最低p值的基因表达水平，或从表达水平获得的风险评分(参见N Engl J.Med2007；356：11-20)。测量结果或对照组的结果是用相同方法获得的表达水平或表达模式(高表达或低表达)，并且可以根据不论患者是否患有肝癌都以恒定表达水平表达的对照基因(或基因的组)(B2M、GAPDH、HMBS、HPRT1和SDHA等)的平均表达水平来确定。
通过与从上述患者组获得的对照组的结果进行比较，来表征肝癌患者的测量结果，从而可以检测出其间的差异，并且可以使用任何可以检测出这种差异的物质来作为用于特异性地检测肝癌预后标志物的表达水平和/或表达模式的物质。对照组结果与测量结果之间的差异的检测结果能够为确定肝癌的治疗方法提供信息。
另外，本发明提供一种用于预测肝癌预后的方法，所述方法包括：(A)检测获自肝癌患者的样品中的选自由上表2所示的基因组成的组的一种或至少两种基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)的表达水平或表达模式中的一项或多项；和(B)将步骤(A)的结果与对照组的测量结果进行比较，从而预测肝癌预后。
上述由基因组成的组还可以包含上表3所示的基因(已在对本发明的用于根据肝癌分期来预测预后的预测肝癌预后用组合物和试剂盒的说明中有所描述)。
除非存在矛盾，针对本发明的用于根据肝癌分期来预测预后的肝癌预后预测方法而提及的内容也等同地适用于上述方法。
此外，除非存在矛盾，针对本发明的组合物或试剂盒而提及的内容也等同地适用于本发明的方法。
本发明的预测肝癌预后的方法可以是为预测肝癌预后提供信息的方法。
此外，本发明提供包含在本发明的组合物中的核酸或抗体在预测肝癌预后中的应用。
此外，本发明提供用于预测肝癌预后的核酸或抗体，且所述核酸或抗体是包含在本发明的组合物中的核酸或抗体。
除非存在矛盾，针对本发明的标志物、组合物或试剂盒、方法和用途而提及的内容都等同地适用。
发明效果
本发明的标志物、组合物或试剂盒以及方法使得可以有效地预测肝癌预后、优选根据分期来有效地预测肝癌预后。
附图说明
图1图示了BCLC分类表。
图2～图106是Kaplan-Meier曲线，其图示了通过在复发、存活和无病存活方面测量本发明的肝癌预后标志物而得到的数据。
具体实施方式
下文中，将借助于实施例来详细说明本发明；但描述这些实施例仅是为了帮助理解本发明，而不是以任何方式限制本发明的范围。
实施例1：预测肝癌预后
用下述方法发现了可用于预测肝癌预后的标志物，经确认，使用这些标志物可以预测肝癌预后。
1-1.RNA抽提和cDNA合成
从547位肝癌患者(已诊断出其出现肝癌，并确认了其肝癌的发展)中采集肝癌组织和附近的正常组织。这些肝癌患者是在诊断后经历了癌症肝脏切除术但没有接受其他治疗的患者，所述组织是在所述癌症肝脏切除术前采集并冷冻的组织。
抽提每份组织的RNA，并按照下述方法合成cDNA。
按照制造商的使用说明，使用RNeasy Minikit(Qiagen，德国)从肝癌组织和附近的正常组织中抽提出总RNA。使用Bioanalyzer2100(Agilent Technologies，美国)对所获得的RNA抽提物的总RNA进行称重。在抽提步骤中进行DNA酶I处理，以将污染了的基因组DNA从RNA抽提物中除去。将包含4μg总RNA的样品与2μl的10μM寡聚d(T)18引物(Genotech，韩国)在70℃温育7分钟，随后在冰上冷却5分钟。单独制备酶混合物[总体积11μl，制备方法为：添加2μl0.1M的DTT(Duchefa，荷兰)、2μl10×逆转录缓冲液、5μl2mM的dNTP、1μl200U/μl的MMLV逆转录酶和1μl40U/μl的RNA酶抑制剂(Enzynomics，韩国)]。将该酶混合物添加到包含RNA的样品中，之后将其在42℃温育90分钟，而后在80℃温育10分钟，从而使逆转录酶失活。添加用焦碳酸二乙酯(DEPC)处理过的水使上述样品的最终体积为400μl。
1-2：定量实时PCR
按照制造商的使用说明，在下表所示的基因标志物的存在下，使用PRISM7900HT(Applied Biosystems，美国)对从实施例1-1获得的每个cDNA样品进行实时PCR扩增。
该实时PCR分析在10μl的总体积中进行，其中包含5μl的2×Taqman基因表达主混合物(Applied Biosystems，美国)、5μM的正向引物和反向引物各1μl、1μl的1μM探针(Genotech，韩国)和2μl的cDNA(在对照组中为等量的水)。上述扩增以以下步骤组成的循环来进行：在95℃进行10分钟的解链步骤，之后是在95℃进行15秒的解链步骤，以及在60℃进行1分钟的合成步骤。使用Primer Express3.0(AppliedBiosystems，美国)来设计引物和探针的序列，并用FAM标记所有探针序列的5′末端，用TAMRA标记所有探针序列的3′末端。将下表16中的以下引物和探针序列用于每种标志物。
[表16]
基因 正向引物(SEQ ID NO.) 反向引物(SEQ ID NO.) 探针(SEQ ID No.)
UVRAG AATGTGCACCCTAGCCAAGAA(58) TGCTCGCTGGGTAGGAGAGT(59) AGAAGCCCTCTCCGGGCACCG(60)
NAMPT CGGCAGAAGCCGAGTTCA(61) GCTTGTGTTGGGTGGATATTGTT(62) CATCCTCCTGGCCACCGACTCCTAC(63)
STAT3 GCCAGAGAGCCAGGAGCAT(64) GGTGTCACACAGATAAACTTGGTCTT(65) AGCTGACCCAGGCGCTGCCC(66)
CIAP2 TGGTTTCCAAGGTGTGAGTACTTG(67) GGGCTGTCTGATGTGGATAGC(68) TCATCCGTCAAGTTCAAGCCAGTTACCCTC(69)
BHLHE41 CAAGCCTACCGTCCCACAGA(70) CCAGTAACTGTCTCTCTTGCAAATG(71) CCCAAAAATCGAAACAGAGGAAACGAACAG(72)
MMP2 GGTTGTCTGAAGTCACTGCACAGT(73) CTCGGTAGGGACATGCTAAGTAGAG(74) CATCTCAGCCCACATAGTGATGGTTCCC(75)
SESN2 TGCCTCCGGGACTGACA(76) TGACCCTGACTTTCACATTGATG(77) TGCCTTCTCTCCCCTGTCATTTCCAG(78)
HMGB1 CGGACAAGGCCCGTTATG(79) AGAGGAAGAAGGCCGAAGGA(80) AAAAGAAGTTCAAGGATCCCAATGCACCC(81)
SIRT1 AAAAACCTCCACGAACACAAAAA(82) TGCTTGGTCTAAAAGTGTGACAATC(83) TCAGAGTTGCCACCCACACCTCTTCA(84)
RPS19BP1 CGGAAGACGAAGGCAATTCA(85) GCCGACTTGGGCACCTTT(86) CCAGAAACTGCGGAACTCGGCCA(87)
LAMP2 GCCCCGCCCCTAGTCTTA(88) ACCGACCACAGCCTTGCA(89) CTCGCACTGAAGCGCCGATTCC(90)
AGER CCGAGTCCGTGTCTACCAGATT(91) CACATGTCCCCACCTTATTGG(92) TCTGCCTCTGAACTCACGGCTGGTGT(93)
SESN3 TCTGCCTGAACTGGTACATGCT(94) TGGATTGATACCACTACCAAAAACA(95) TGGTCCTCCTGGCACATTATCATGCTTT(96)
ID2 AACGACTGCTACTCCAAGCTCAA(97) GGATTTCCATCTTGCTCACCTT(98) TGCCCAGCATCCCCCAGAACAA(99)
TCF3 GCTGCCTTTGGTCTCTGGTTT(100) AGAAATGCAATGCTCAGTCTAGGA(101) AGTCCCGTGTCTCTCGCTATTTCTGCTG(102)
HMGB2 TGCCGGGAAGAGCACAA(103) TCCATCTCTCCGAACACTTCTTG(104) ACACCCGGACTCTTCCGTCAATTTCG(105)
TP63 GCTCCACCTTCGATGCTCTCT(106) TGCTCGACTGCTGGAAGGA(107) ATCACCCGCCATCCCCTCCAAC(108)
RAGE CCAATTTGTCCCCACAATGC(109) GGGCGGCGATTCTCTCA(110) CCTCCTGCACGCAATGGTGGC(111)
KIAA1967 CGTTGTTGCATGCTCTTTGTG(112) CCAGCAAAAACTTAATCTGCTTCA(113) CCAAGGGAGACGCCAGAGCATCC(114)
SATB1 GACCCGGCCACGAACA(115) GTCGAGCTGGGCAGACAGA(116) TTTCATACAAGACGTGGGCCTGTACCCTG(117)
RAPTOR GATGGCACTCAGCGAATGC(118) ATGCGCACATCTCCATTGAC(119) CTCCCTGCAGAAGCGTCCCGAC(120)
SESN1 TCCTGGGTGCATTCAGTCTCT(121) GGAGCTGCACAGCCTTTAAAGT(122) TGCCTCTGCCTGCCTCCTGGTC(123)
CCNG2 TCCCAGTATGATGGCCAGTCA(124) ATAAGGCCAGCCAAAACTCAAG(125) ATGCTGCTCTTCCCGTCCACAAGTG(126)
CDH1 AAATCTGAAAGCGGCTGATACTG(127) CGGAACCGCTTCCTTCATAG(128) CCCCACAGCCCCGCCTTATGA(129)
FASLG GAGATCCAGCTTGCCTCCTCTT(130) CGGTTTTACTTCTTCTCAGTCCTGTA(131) AGCAACAGGGTCCCGTCCTTGACA(132)
CASP3 CAGTGGAGGCCGACTTCTTG(133) ATGAACCAGGAGCCATCCTTT(134) TCCACAGCACCTGGTTATTATTCTTGGCG(135)
BECN1 GATGGTGTCTCTCGCAGATTCA(136) TCAGATGCCTCCCCAATCAG(137) ATGTCCACAGAAAGTGCCAACAGCTTCAC(138)
CDH2 GCACCCGCCTCAGTCAACT(139) CAACATGGTACCGGCATGAA(140) AATGAAAACCCTTATTTTGCCCCCAATCC(141)
TWIST1 TCCGCGTCCCACTAGCA(142) AGTTATCCAGCTCCAGAGTCTCTAGAC(143) CACCCCCTCAGCAGGGCCG(144)
MMP9 GGGCTCCCGTCCTGCTT(145) ACTCCTCCCTTTCCTCCAGAAC(146) TGCCATGTAAATCCCCACTGGGACC(147)
VEGF GCTTACTCTCACCTGCTTCTGAGTT(148) TGGGCTGCTTCTTCCAACA(149) AGACCACTGGCAGATGTCCCGGC(150)
ATG12 CGACAGCTTCGATTTGAATGAC(151) GGGAGCGTCGCAAAGGA(152) TGTAATTGCGTCCCCCTACTCCGGC(153)
DIABLO AATCACATTCAGCTGGTGAAACTG(154) TGCCAGCTTGGTTTCTGCTT(155) AAGAGGTGCACCAGCTCTCCCGG(156)
E2F1 CTGGACCACCTGATGAATATCTGT(157) CAATGCTACGAAGGTCCTGACA(158) CAGCTGCGCCTGCTCTCCGA(159)
LAMP1 TGCACTCAGATTTAAGCCTTACAAA(160) TCACCACGAGTGACCTTCATG(161) AAGCCTCTGGCCGTCACACGTAGG(162)
LC3 AACCAGCACAGCATGGTGAGT(163) CCTCGTCTTTCTCCTGCTCGTA(164) TCCACGCCCATCGCGGACA(165)
ATG7 CGGATGAATGAGCCTCCAA(166) GGACATTATCAAACCGTGAAAGAA(167) TCTTGGGCTTGTGCCTCACCAGATC(168)
TKT GAGGCTGTGTCCAGTGCAGTAG(169) CCACTTCTTGGTACCCGGTTA(170) CCTGGCATCACTGTCACCCACCTG(171)
AIFM1 TGAAGATCTCAATGAAGTAGCCAAACTAT(172) CTGCAGTGGGTTTGCCAAT(173) CAACATTCATGAAGACTGAAGCCCCACA(174)
BNIP3 TTCCCCCCAAGGAGTTCCT(175) CGCTCGTGTTCCTCATGCT(176) ACCCGAAGCGCACGGCCAC(177)
ATG3 CCATTGAAAATCACCCTCATCTG(178) CACCTCAGCATGCCTGCAT(179) CACCACCTCCCATGTGTTCAGTTCACC(180)
DRAM CAGCCGCCTTCATTATCTCCTA(181) TGGAGGTGTTGTTCCCGTATC(182) TGCTCTCCGGGCACGTCAACC(183)
ATG5 TTTCCTCCACTGCCATCATTAA(184) GGCCAAAGGTTTCAGCTTCA(185) CCTCAGCTGTGACATGAAAGACTTACCGG(186)
NNMT TTGAGGTGATCTCGCAAAGTTATT(187) CTCGCCACCAGGGAGAAA(188) CCACCATGGCCAACAACGAAGGAC(189)
PRKAA1 GGCAGTTGCCTACCATCTCATAA(190) GCCGAGTCAGGTGATGATCA(191) TCTATTTGGCGACAAGCCCACCTGATT(192)
CASP8 CCTTCTGATTGATGGTGCTATTTTG(193) GCGGTGAGCCGAGATCAC(194) CAGAATCTCGCTCTGTCGCCCAGG(195)
ULK1 TCGCGGCCGCATGT(196) AAGGGTCCAGCACTATCAAGAGA(197) AGCAGGTCCTGGGCGCCTCAAC(198)
BCL2L1 GATTGCCTTTGTTTTGATGTTTGT(199) GGAAAGGGAACCCAGGTTAGTG(200) CAGAATTGATCATTTTCCCCCCACTCTCC(201)
FAS AATGGTGTCAATGAAGCCAAAAT(202) GTCATACGCTTCTTTCTTTCCATGA(203) TGACAATGTCCAAGACACAGCAGAACAGAA(204)
CSE1L GCATGATCCTGTAGGTCAAATGG(205) CAGGCGGTAGACAACTTGTGAA(206) AATAACCCCAAAATTCACCTGGCACAGTCA(207)
FRAP1 AGGCCGCATTGTCTCTATCAA(208) GCAGTAAATGCAGGTAGTCATCCA(209) TGCAATCCAGCTGTTTGGCGCC(210)
AKT1 TCTCGGGTGCATTTGAGAGAA(211) ACAGCACAAAAACGTCTTTCCA(212) CCACGCTGTCCTCTCGAGCCCA(213)
BAX GGTTGTCGCCCTTTTCTACTTTG(214) CAGTTCCGGCACCTTGGT(215) CAGCAAACTGGTGCTCAAGGCCCT(216)
BCL2 CATGTGTGTGGAGAGCGTCAA(217) GCCGGTTCAGGTACTCAGTCA(218) CCTGGTGGACAACATCGCCCTGT(219)
PTEN TGGCGGAACTTGCAATCC(220) GCTGAGGGAACTCAAAGTACATGA(221) ATATTCCTCCAATTCAGGACCCACACGAC(222)
CBS GTTGGCAAAGTCATCTACAAGCA(223) GGGCGAAGTGGTCCATCTC(224) ACGCTGGGCAGGCTCTCGCAC(225)
XIAP GACAGGCCATCTGAGACACATG(226) AGCATAGTCTGGCCAGTTCTGAA(227) AGACACCATATACCCGAGGAACCCTGCC(228)
每种标志基因的表达都平行测量3次，随后通过减去5种参照基因(B2M、GAPDH、HMBS、HPRT1和SDHA)的平均表达来进行标准化。将下表17中的引物和探针序列用于参照基因。
[表17]
Figure BDA00003059959300511
测量每种标志物的CT(达到阈值所需的循环数)，并计算ΔCT值(每种标志物的CT减去参照基因的平均CT)。mRNA的拷贝数以2-ΔCT计算。使用对cDNA样品的梯度稀释液进行同时扩增的结果构建了标准曲线。
从以上结果可以看出，利用包含在本发明的组合物中的核酸，可以测量标志物的表达水平和表达模式。此外，由于mRNA作为转录本被翻译成蛋白，还可以推知，利用包含在本发明的组合物中的抗体，还可以测量标志物的表达水平和表达模式。
1-3.统计学分析
考虑到从实施例1和2获得的每种标志物的标准化表达以及提供肝癌组织的患者的进展，完成了Kaplan-Meier曲线，并随后进行了显著性分析。
基于提供了肝癌组织的患者的进展，对于复发、存活和无病存活的各种情况，按时期升序排列了患者。通过用存活者(或复发的患者)的数量除以面临风险的患者数量，计算出了区间存活率(或区间复发率)。累积存活率(或累积复发率)为条件概率，其通过以下方法来计算：用之前的累积存活率(或累积复发率)乘以当前的区间存活率(或区间复发率)。Kaplan-Meier曲线被构建为阶跃函数，其中横轴为存活时间(或观察期)，纵轴为累积存活率(或累积复发率)。
对于每种标志物，完成了对应于复发、存活和无病存活的Kaplan-Meier曲线。根据经实验确定的在统计学上具有显著性的参照值，将在实施例1和2中测得的每种标志物的表达分类为高表达和低表达，并使每种标志物的高表达情形和低表达情形彼此分开，从而完成Kaplan-Meier曲线。作为所述参照值，选择了在连续变量的回归分析结果中具有最低p值的基因表达值(见N Engl J Med2007；356：11-20)。将这些值用于Kaplan-Meier曲线以绘制成图(J.Amer.Statist.Assn.53：457481，1958)。用于确定Kaplan-Meier曲线中的显著性的标准是单基因或基因组合的p值是否低于0.05。
绘制Kaplan-Meier曲线是为了在547位分期尚未得到归类的肝癌患者中针对57种单基因、31种单基因和其中的至少两种的组合组成的基因的组来预测复发、存活和无病存活。将57种单基因的结果示于图2～22中。57种单基因的关于复发的Kaplan-Meier曲线示于图2～8中，57种单基因的关于存活的Kaplan-Meier曲线示于图9～15中，57种单基因的关于无病存活的Kaplan-Meier曲线示于图16～22中。
从这些图中可以确认，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，每种标志物都形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在每种标志物显示出高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异，因此，每种标志物的表达模式都可以作为显示出患者的复发可能性或存活可能性的指数。
此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得χ2检验统计数字。其结果示于下表18～21中。57种标志物的结果示于表18中，单独使用或组合使用的31种标志物的结果示于表19～21中。其中，表19示出了31种标志物的复发预测结果，表20示出了31种标志物的存活预测结果，表21示出了31种标志物的无病存活预测结果。
[表18]
Figure BDA00003059959300531
[表19]
Figure BDA00003059959300542
Figure BDA00003059959300551
[表20]
Figure BDA00003059959300552
Figure BDA00003059959300561
[表21]
Figure BDA00003059959300571
Figure BDA00003059959300572
在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况中，针对复发、存活和无病存活的所有p值都小于0.05，这是想要的结果。p值越低，统计学显著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
从以上结果可以发现，所组合的本发明的标记物越多，p值就越低。这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，也就意味着，在基于这些标志物的组合对预后进行预估时所获得的准确性会提高更多。
此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测A2组的肝癌预后。
另外，对31种基因进行了交叉验证。在该交叉验证中，将未根据分期分类的患者随机分为两组(阳性组：274位患者；测试组：273位患者)。在阳性组的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。
在所有未根据分期进行分类的患者中针对31种基因中的两种以上的组合对复发、存活和无病存活进行了预测，在对该预测的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：
复发：ATG3_FASLG_ID2_RPS19BP1_SESN3_TCF3(94％在p＜0.05的水平)
存活：CSE1L_FAS_FRAP1_CDH1_BHLHE41_SESN2(95％在p＜0.0001的水平)
无病存活：ATG12_FASLG_ID2_STAT3_RPS19BP1_TCF3(95.0％在p＜0.05的水平)
实施例2：在A1组中预测肝癌预后
以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于A1组(门静脉侵袭阴性患者组，BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤)的患者(277位患者)进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活，其结果示于图23～43中。针对复发的Kaplan-Meier曲线示于图23～29中，针对存活的Kaplan-Meier曲线示于图30～36中，针对无病存活的Kaplan-Meier曲线示于图37～43中。
从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表22～29中。仅使用一种标记物的结果示于表22中，两种标记物组合的结果示于表23中，三种标记物组合的结果示于表24中，四种标记物组合的结果示于表25中，五种标记物组合的结果示于表26中，六种标记物组合的结果示于表27中，七种标记物组合的结果示于表28中，八种标记物组合的结果示于表29中。
[表22]
Figure BDA00003059959300591
Figure BDA00003059959300601
[表23]
Figure BDA00003059959300602
Figure BDA00003059959300611
[表24]
Figure BDA00003059959300621
[表25]
Figure BDA00003059959300622
Figure BDA00003059959300631
[表26]
Figure BDA00003059959300632
[表27]
Figure BDA00003059959300642
Figure BDA00003059959300651
[表28]
Figure BDA00003059959300652
Figure BDA00003059959300661
[表29]
Figure BDA00003059959300662
Figure BDA00003059959300671
Figure BDA00003059959300681
从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，换言之，在基于这些标志物的组合对预后进行预估时，所获得的准确性会提高更多。
因此发现，表22～29中的标志物和/或标志物组合在预测A1组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测A1组的肝癌预后。
还可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测A1组的肝癌预后。
此外，对认为具有统计学显著性的标志物组合进行交叉验证。将每个患者组的患者随机分为两组(阳性组：139位患者；测试组：138位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。
在对A1组的复发、存活和无病存活的预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：
复发：ATG7_FRAP1_LC3_NNMT_STAT3(95％在p＜0.05的水平)
存活：AKT1_CDH1_ID2(98.7％在p＜0.05的水平)
无病存活：FRAP1_LC3_TKT_HMGB1_STAT3_TWIST1(84.0％在p＜0.05的水平)
实施例3：在A2组中预测肝癌预后
以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于A2组{门静脉侵袭阴性患者组，具有尺寸大于5cm的肿瘤}的患者(123位患者)进行实验，以与实施例1中相同的方式进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活，其结果示于图44～46中。针对复发的Kaplan-Meier曲线示于图44～50中，针对存活的Kaplan-Meier曲线示于图51～57中，针对无病存活的Kaplan-Meier曲线示于图58～64中。
从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表30～37中。仅使用一种标记物的结果示于表30中，两种标记物组合的结果示于表31中，三种标记物组合的结果示于表32中，四种标记物组合的结果示于表33中，五种标记物组合的结果示于表34中，六种标记物组合的结果示于表35中，七种标记物组合的结果示于表36中，八种标记物组合的结果示于表37中。
[表30]
Figure BDA00003059959300691
Figure BDA00003059959300701
[表31]
Figure BDA00003059959300702
Figure BDA00003059959300711
[表32]
Figure BDA00003059959300712
Figure BDA00003059959300721
[表33]
Figure BDA00003059959300722
[表34]
Figure BDA00003059959300741
[表35]
Figure BDA00003059959300742
Figure BDA00003059959300761
[表36]
Figure BDA00003059959300762
[表37]
Figure BDA00003059959300772
Figure BDA00003059959300781
Figure BDA00003059959300791
从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，也就是说，在基于这些标志物的组合对预后进行估计时，所获得的准确性会提高更多。
因此发现，表30～37中的标志物和/或标志物组合在预测A2组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测A2组的肝癌预后。
此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测A2组的肝癌预后。
此外，对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组：62位患者；测试组：61位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。
在对A2组的复发、存活和无病存活的预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：
复发：TKT_SESN2_VEGF(65.0％在p＜0.05的水平)
存活：DIABLO_FAS_LAMP1_BHLHE41_SESN2(83.3％在p＜0.05的水平)
无病存活：TKT_SESN2_VEGF(82.0％在p＜0.05的水平)
实施例4：在B组中预测肝癌预后
以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于B组{门静脉侵袭阴性患者组，BCLC分期系统的中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤}的患者(78位患者)进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活，其结果示于图65～85中。针对复发的Kaplan-Meier曲线示于图65～71中，针对存活的Kaplan-Meier曲线示于图72～78中，针对无病存活的Kaplan-Meier曲线示于图79～85中。
从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表38～45中。仅使用一种标记物的结果示于表38中，两种标记物组合的结果示于表39中，三种标记物组合的结果示于表40中，四种标记物组合的结果示于表41中，五种标记物组合的结果示于表42中，六种标记物组合的结果示于表43中，七种标记物组合的结果示于表44中，八种标记物组合的结果示于表45中。
[表38]
Figure BDA00003059959300801
Figure BDA00003059959300811
[表39]
Figure BDA00003059959300812
Figure BDA00003059959300821
[表40]
Figure BDA00003059959300822
Figure BDA00003059959300831
[表41]
Figure BDA00003059959300832
[表42]
Figure BDA00003059959300842
Figure BDA00003059959300851
[表43]
Figure BDA00003059959300852
Figure BDA00003059959300861
[表44]
Figure BDA00003059959300862
Figure BDA00003059959300871
Figure BDA00003059959300881
[表45]
Figure BDA00003059959300891
从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，换言之，在基于这些标志物的组合对预后进行预估时，所获得的准确性会提高更多。
因此发现，表38～45中的标志物和/或标志物组合在预测B组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测B组的肝癌预后。此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测B组的肝癌预后。
此外，对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组：39位患者；测试组：39位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。
在对B组的存活预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：
存活：DIABLO_BECN1_SIRT1(79.7％在p＜0.05的水平)
实施例5：在C组中预测肝癌预后
以与实施例1中相同的方式进行实验，不同之处在于：对经确定属于C组{门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何}的患者(69位患者)进行实验。绘制了Kaplan-Meier曲线来预测复发、存活和无病存活，其结果示于图86～106中。针对复发的Kaplan-Meier曲线示于图86～92中，针对存活的Kaplan-Meier曲线示于图93～99中，针对无病存活的Kaplan-Meier曲线示于图100～106中。
从这些图中可以看出，在针对复发、存活和无病存活而完成的Kaplan-Meier曲线中，上述标志物形成了高表达情形和低表达情形彼此明显区分开的曲线。这意味着，在所述标志物为高表达和低表达的情形之间，在区间复发率或区间存活率方面以及在基于其的累积复发率或累积存活率方面都有明显差异，因此，所述标志物的表达模式可以作为显示出患者的复发可能性或存活可能性的指数。
此外，显著性检验以下述方式进行：通过计算每个复发点或死亡点处的观察值和预期值，对每种标记物及其组合进行时序检验，从而获得p值。其结果示于下表46～53中。仅使用一种标记物的结果示于表46中，两种标记物组合的结果示于表47中，三种标记物组合的结果示于表48中，四种标记物组合的结果示于表49中，五种标记物组合的结果示于表50中，六种标记物组合的结果示于表51中，七种标记物组合的结果示于表52中，八种标记物组合的结果示于表53中。
[表46]
Figure BDA00003059959300911
[表47]
Figure BDA00003059959300922
Figure BDA00003059959300931
[表48]
Figure BDA00003059959300932
Figure BDA00003059959300941
[表49]
Figure BDA00003059959300942
Figure BDA00003059959300951
[表50]
Figure BDA00003059959300952
Figure BDA00003059959300961
[表51]
Figure BDA00003059959300962
Figure BDA00003059959300971
[表52]
Figure BDA00003059959300981
[表53]
Figure BDA00003059959300982
Figure BDA00003059959300991
Figure BDA00003059959301001
以上各表呈现了每种基因及其组合的p值。
从以上表中可以确定，在复发、存活和无病存活方面，每种标志物或其组合都显示出了足够低以至于可以认为具有显著性的p值。特别而言，在两种以上标志物组合的情况中，针对复发、存活和无病存活的所有p值都较低。特别而言，发现了这种情况：单基因的p值相对高，但是当将该标志物与其他标志物组合使用时p值有所下降。p值越低，统计学显著性就越高。因此，低p值意味着，利用每种标志物或其组合对肝癌预后进行的预估是非常准确的。
这意味着，所组合的本发明的标记物越多，所显示出的p值就越低，即显著性就越高，也就是说，在基于这些标志物的组合对预后进行估计时，所获得的准确性会提高更多。
因此发现，表41～48中的标志物和/或标志物组合在预测C组的肝癌预后(复发、存活和无病存活)时有效，利用针对这些标志物的核酸和抗体可以有效地预测C组的肝癌预后。此外可以发现，使用本发明的针对这些标志物的预测肝癌预后的方法，可以有效地预测C组的肝癌预后。
此外，对认为具有统计学显著性的标志物组合进行了交叉验证。将每个患者组的患者随机分为两组(阳性组：35位患者；测试组：34位患者)。在阳性组结果(以与实施例1相同的方式获得)中的认为具有统计学显著性的参照值固定的情况下，对于测试组，经计算，对复发、存活和无病存活的预估准确性在p＜0.05或p＜0.001的水平。
在对C组的复发、存活和无病存活预测进行的交叉验证结果中，在各方面都显示出优异的预后准确性的代表性实例如下：
复发：FAS_TCF3_FASLG_RPS19BP1(69.0％在p＜0.05的水平)
存活：CASP3_CDH2_CIAP2(77.0％在p＜0.05的水平)
无病存活：FAS_TCF3_FASLG(75.0％在p＜0.05的水平)
【工业应用性】
本发明提供用于预测肝癌预后的标志物、用于预测肝癌预后的组合物或试剂盒(优选为用于根据分期来预测肝癌的肝癌预后预测用组合物或试剂盒)以及用于预测肝癌预后的方法。本发明的标志物、组合物或试剂盒以及方法使得可以有效地预测肝癌预后、优选根据分期来有效地预测肝癌预后。
Figure IDA00003059959900021
Figure IDA00003059959900041
Figure IDA00003059959900051
Figure IDA00003059959900061
Figure IDA00003059959900071
Figure IDA00003059959900081
Figure IDA00003059959900091
Figure IDA00003059959900101
Figure IDA00003059959900111
Figure IDA00003059959900131
Figure IDA00003059959900141
Figure IDA00003059959900151
Figure IDA00003059959900161
Figure IDA00003059959900171
Figure IDA00003059959900181
Figure IDA00003059959900201
Figure IDA00003059959900211
Figure IDA00003059959900221
Figure IDA00003059959900231
Figure IDA00003059959900241
Figure IDA00003059959900251
Figure IDA00003059959900261
Figure IDA00003059959900271
Figure IDA00003059959900281
Figure IDA00003059959900291
Figure IDA00003059959900301
Figure IDA00003059959900321
Figure IDA00003059959900331
Figure IDA00003059959900341
Figure IDA00003059959900351
Figure IDA00003059959900361
Figure IDA00003059959900371
Figure IDA00003059959900381
Figure IDA00003059959900391
Figure IDA00003059959900401
Figure IDA00003059959900431
Figure IDA00003059959900441
Figure IDA00003059959900451
Figure IDA00003059959900461
Figure IDA00003059959900481
Figure IDA00003059959900501
Figure IDA00003059959900521
Figure IDA00003059959900531
Figure IDA00003059959900541
Figure IDA00003059959900551
Figure IDA00003059959900561
Figure IDA00003059959900571
Figure IDA00003059959900581
Figure IDA00003059959900591
Figure IDA00003059959900611
Figure IDA00003059959900631
Figure IDA00003059959900641
Figure IDA00003059959900661
Figure IDA00003059959900681
Figure IDA00003059959900691
Figure IDA00003059959900701
Figure IDA00003059959900721
Figure IDA00003059959900741
Figure IDA00003059959900751
Figure IDA00003059959900761
Figure IDA00003059959900771
Figure IDA00003059959900781
Figure IDA00003059959900791
Figure IDA00003059959900801
Figure IDA00003059959900811
Figure IDA00003059959900821
Figure IDA00003059959900831
Figure IDA00003059959900841
Figure IDA00003059959900851
Figure IDA00003059959900861
Figure IDA00003059959900871
Figure IDA00003059959900881
Figure IDA00003059959900891
Figure IDA00003059959900901
Figure IDA00003059959900911
Figure IDA00003059959900921
Figure IDA00003059959900931
Figure IDA00003059959900941
Figure IDA00003059959900951
Figure IDA00003059959900961
Figure IDA00003059959900971
Figure IDA00003059959900981
Figure IDA00003059959900991
Figure IDA00003059959901001
Figure IDA00003059959901011
Figure IDA00003059959901021
Figure IDA00003059959901041
Figure IDA00003059959901051
Figure IDA00003059959901071
Figure IDA00003059959901081
Figure IDA00003059959901091
Figure IDA00003059959901101
Figure IDA00003059959901121
Figure IDA00003059959901131
Figure IDA00003059959901141
Figure IDA00003059959901151
Figure IDA00003059959901171
Figure IDA00003059959901181
Figure IDA00003059959901191
Figure IDA00003059959901201
Figure IDA00003059959901211
Figure IDA00003059959901221
Figure IDA00003059959901241
Figure IDA00003059959901251
Figure IDA00003059959901271

Claims (41)

1.一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：
对选自下表所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸，或对所述基因编码的蛋白有特异性的抗体；并且
所述组合物或试剂盒用于根据选自A1组、A2组、B组或C组的一个或多个组中的分期来预测肝癌预后；其中A1组为门静脉侵袭阴性患者组，患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm以下的肿瘤或3个以下的尺寸为3cm以下的肿瘤；A2组为门静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤；B组为门静脉侵袭阴性患者组，患者处于BCLC分期系统的中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤；C组为门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何：
[表1]
Figure FDA00003403731400011
Figure FDA00003403731400021
2.如权利要求1所述的组合物或试剂盒，其中，由基因组成的所述组是由下表所示的基因组成的组：
[表2]
Figure FDA00003403731400022
Figure FDA00003403731400031
3.如权利要求2所述的组合物或试剂盒，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
Figure FDA00003403731400032
4.如权利要求1所述的组合物或试剂盒，其中，所述预后是对复发、存活或无病存活的预测。
5.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A1组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表4]
一种 两种的组合 三种的组合 四种的组合 BCL2L1 FRAP1_SESN1 FRAP1_CASP3_CDH2 ID2_NAMPT_RPS19BP1_SESN3 BECN1 FRAP1_TWIST1 ID2_CDH2_SESN3 FRAP1_LC3_CASP3_CDH2 BAX FRAP1_CASP3 FRAP1_CDH2_SESN1 FRAP1_TKT_CASP3_CDH2 CDH2 FRAP1_CCNG2 FRAP1_LC3_CASP3 BAX_FRAP1_LC3_CDH2 NAMPT BAX_FRAP1 FRAP1_LC3_TWIST1 ID2_CDH2_NAMPT_SESN3 TWIST1 FRAP1_NNMT BAX_FRAP1_LC3 CBS_ID2_CDH2_SESN3 RPS19BP1 BCL2L1_FRAP1 FRAP1_CDH2_TWIST1 FRAP1_LC3_CDH2_KIAA1967 MMP2 AIFM1_FRAP1 FRAP1_NNMT_CDH2 FRAP1_CDH2_SESN1_STAT3 SESN3 FRAP1_RAGE FRAP1_LC3_NNMT FRAP1_LC3_NNMT_CDH2 ID2 FRAP1_VEGF BAX_FRAP1_CDH2 FRAP1_LC3_CDH2_RAPTOR AGER ID2_CDH2 FRAP1_SESN1_STAT3 ID2_CDH2_RPS19BP1_SESN3 ATG12 FRAP1_PTEN AIFM1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1 NAMPT_SESN3 FRAP1_LC3_VEGF FRAP1_LC3_CDH2_VEGF BCL2_FRAP1 FRAP1_NNMT_MMP2 FRAP1_LC3_SESN1_STAT3 CDH2_SESN3 FRAP1_LC3_RAGE FRAP1_LC3_CDH2_RAGE FRAP1_RAPTOR FRAP1_CCNG2_CDH2 FRAP1_LC3_NNMT_STAT3 FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 ID2_CDH2_MMP2_SESN3 FRAP1_XIAP FRAP1_CDH2_VEGF FRAP1_LC3_CASP3_STAT3 BECN1_SESN3 FRAP1_LC3_CCNG2 AIFM1_FRAP1_LC3_CDH2 HMGB1_TWIST1 FRAP1_CASP3_MMP2 BCL2L1_FRAP1_LC3_CDH2 ID2_NAMPT BCL2L1_FRAP1_LC3 FRAP1_LC3_PTEN_CDH2 FRAP1_PRKAA1 FRAP1_LC3_SESN1 BAX_FRAP1_LC3_BECN1 ID2_RPS19BP1 FRAP1_CDH2_KIAA1967 BAX_FRAP1_LC3_RPS19BP1 BAX_LC3 AIFM1_FRAP1_LC3 FRAP1_CASP3_CDH2_STAT3 FRAP1_TP63 FRAP1_LC3_RAPTOR LC3_HMGB1_STAT3_TWIST1 ATG12_SESN3 FRAP1_CDH2_RAGE BAX_FRAP1_TKT_CDH2 BAX_TWIST1 BAX_FRAP1_MMP2 FRAP1_LC3_CCNG2_CDH2 RPS19BP1_SESN3 FRAP1_LC3_PTEN FRAP1_TKT_CDH2_SESN1 BAX_MMP2 FRAP1_TKT_CASP3 FRAP1_LC3_HMGB1_TWIST1 SESN1_STAT3 FRAP1_PTEN_CDH2 FRAP1_NNMT_TKT_CDH2 LC3_TWIST1 FRAP1_TKT_TWIST1 BAX_FRAP1_LC3_MMP2 MMP2_NAMPT FRAP1_LC3_KIAA1967 FRAP1_LC3_CCNG2_STAT3 ID2_BECN1 BAX_FRAP1_TKT FRAP1_LC3_STAT3_TWIST1
BCL2L1_LC3 BCL2_FRAP1_CDH2 FRAP1_TKT_CDH2_TWIST1 MMP2_RPS19BP1 FRAP1_HMGB1_TWIST1 FRAP1_LC3_NNMT_MMP2 ATG7_BCL2L1 FRAP1_RPS19BP1_TWIST1 BAX_FRAP1_TKT_MMP2 ID2_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_NNMT_CDH2_MMP2 CDH2_HMGB1 FRAP1_TKT_SESN1 FRAP1_LC3_CDH2_SESN1 CDH2_MMP2 FRAP1_RPS19BP1_SESN1 BAX_FRAP1_LC3_TKT ATG7_TWIST1 BAX_FRAP1_BECN1 FAS_FRAP1_CDH2_SESN1 BAX_SESN3 ID2_NAMPT_SESN3 BAX_FAS_FRAP1_LC3 FASLG_NAMPT FRAP1_CCNG2_STAT3 FRAP1_CASP3_CDH2_MMP2 ATG7_BAX BCL2L1_FRAP1_MMP2 ID2_FASLG_NAMPT_SESN3 TKT_NAMPT BCL2_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1 STAT3_TWIST1 FASLG_NAMPT_SESN3 FRAP1_CDH2_HMGB1_TWIST1 BCL2L1_MMP2 AIFM1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2 LC3_KIAA1967 FRAP1_CCNG2_RPS19BP1 DRAM_ID2_CDH2_SESN3 BAX_BECN1 BAX_FRAP1_RPS19BP1 FRAP1_LC3_RPS19BP1_TWIST1 ATG12_ID2 FAS_FRAP1_SESN1 AIFM1_FRAP1_TKT_CDH2 BECN1_MMP2 BCL2L1_FRAP1_TKT FRAP1_TKT_CCNG2_CDH2 AKT1_BAX FRAP1_NNMT_STAT3 BCL2L1_FRAP1_TKT_CDH2 LC3_RAPTOR FRAP1_MMP2_SESN1 DIABLO_ID2_CDH2_SESN3 BAX_RPS19BP1 FRAP1_ID2_TWIST1 BCL2_FRAP1_LC3_CDH2 BAX_TKT FRAP1_CASP3_STAT3 FRAP1_LC3_CASP3_FASLG BAX_SATB1 FRAP1_TKT_CCNG2 FRAP1_CDH2_RPS19BP1_SESN1 LC3_NAMPT FRAP1_MMP2_VEGF FRAP1_LC3_CASP3_MMP2 KIAA1967_MMP2 FRAP1_MMP2_RAPTOR ID2_CDH2_HMGB2_SESN3 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3 ID2_CDH2_MMP2_RPS19BP1_SESN3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1 FRAP1_LC3_CCNG2_CDH2_STAT3 ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 ID2_CDH2_FASLG_NAMPT_SESN3 AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3 LC3_CDH2_HMGB1_STAT3_TWIST1 ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3 ID2_CDH2_HMGB1_RPS19BP1_SESN3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3 ID2_CDH2_MMP2_NAMPT_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_BECN1_CDH2_KIAA1967 FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 BAX_FRAP1_LC3_CDH2_RPS19BP1 AKT1_ATG12_BECN1_CDH2_STAT3_TP63 ID2_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 ID2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_CDH2_HMGB1_TWIST1 FRAP1_LC3_BECN1_CDH2_RAGE_STAT3 FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3 CSE1L_ID2_CDH2_RPS19BP1_SESN3 ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_SESN1_STAT3 BAX_FAS_FRAP1_LC3_CDH2 FRAP1_LC3_NNMT_CDH2_MMP2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR FRAP1_LC3_NNMT_TKT_CDH2_STAT3 LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_KIAA1967 FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3 AIFM1_FRAP1_LC3_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 FRAP1_LC3_BECN1_CASP3_STAT3 CBS_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3 ID2_CDH2_NAMPT_SESN3_STAT3 AKT1_ATG12_FAS_CDH2_STAT3_TP63 LC3_ID2_NAMPT_RPS19BP1_SESN3 LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FRAP1_LC3_NNMT_MMP2_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1
BAX_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_CASP3_CDH2_MMP2_STAT3 FRAP1_TKT_CASP3_CDH2_STAT3 ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3 LC3_HMGB1_RPS19BP1_STAT3_TWIST1 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_VEGF CBS_FRAP1_LC3_CASP3_CDH2 BAX_FRAP1_LC3_TKT_BECN1_CDH2 FRAP1_LAMP1_TKT_CASP3_CDH2 FRAP1_LC3_NNMT_CASP3_CDH2_STAT3 ID2_CDH2_HMGB1_NAMPT_SESN3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3 ID2_HMGB1_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1 FRAP1_LC3_TKT_CDH2_KIAA1967 FRAP1_LC3_BECN1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_HMGB1 ID2_CDH2_FASLG_NAMPT_SESN3_STAT3 ATG7_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_STAT3_TWIST1 BAX_FRAP1_LC3_TKT_MMP2 ATG5_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3 FRAP1_LC3_RPS19BP1_SESN1_STAT3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1 BAX_FRAP1_LC3_CDH2_MMP2 AIFM1_FRAP1_LC3_TKT_CDH2_STAT3 ID2_TCF3_CDH2_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG FRAP1_TKT_CASP3_CDH2_FASLG DRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3 CBS_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CCNG2_CDH2_STAT3 FRAP1_LC3_CDH2_KIAA1967_MMP2 BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1 FAS_FRAP1_LC3_CASP3_CDH2 BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3 BAX_CBS_FRAP1_LC3_CDH2 FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1 FRAP1_LC3_TKT_CDH2_RAPTOR FRAP1_LC3_MMP9_CASP3_CDH2_STAT3 CDH1_ID2_MMP9_TCF3_RPS19BP1 CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3
七种的组合 八种的组合 AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3 AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63 ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63 AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1 ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63 FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63 CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1 FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3 CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63 FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63
AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3 FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1 FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3 ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63 FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR CSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1 FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3 AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3 AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR ATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3 CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3
。
6.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A1组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表5]
一种 两种的组合 三种的组合 四种的组合 ID2 CDH1_ID2 ATG12_CDH1_ID2 ATG12_CDH1_ID2_HMGB2 CDH1 ATG12_CDH1 CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2 LC3 LAMP1_ID2 ATG12_CDH1_HMGB2 ATG12_CDH1_ID2_AGER TKT BNIP3_ID2 CDH1_ID2_AGER ATG12_CDH1_TCF3_HMGB2 AKT1 ATG12_ID2 DRAM_CDH1_ID2 ATG12_DRAM_CDH1_ID2 AIFM1 CDH1_HMGB2 E2F1_CDH1_ID2 AIFM1_CASP8_LC3_CDH1 BNIP3 ID2_HMGB2 CDH1_ID2_LAMP2 ATG12_CDH1_AGER_HMGB2 LAMP1 E2F1_ID2 TKT_CDH1_ID2 ATG12_CDH1_ID2_BECN1 FRAP1 TKT_ID2 LAMP1_CDH1_ID2 ATG12_DRAM_CDH1_HMGB2 DRAM_ID2 CDH1_ID2_MMP2 DRAM_CDH1_ID2_HMGB2 ATG5_ID2 ATG12_DRAM_CDH1 ATG12_CDH1_BHLHE41_HMGB2 ID2_BECN1 CSE1L_CDH1_ID2 CDH1_ID2_HMGB2_LAMP2 ID2_AGER CDH1_ID2_MMP9 ATG12_CDH1_BECN1_HMGB2 ID2_MMP2 BNIP3_CDH1_ID2 E2F1_CDH1_ID2_HMGB2 ATG3_ID2 CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41 ID2_LAMP2 ATG12_CDH1_BHLHE41 CDH1_ID2_BECN1_HMGB2 ULK1_CDH1 ULK1_CDH1_ID2 ATG12_ATG5_CDH1_HMGB2 CSE1L_ID2 LC3_CDH1_ID2 DRAM_CDH1_ID2_AGER TKT_CDH1 ATG12_CDH1_TCF3 LAMP1_CDH1_ID2_HMGB2 LC3_CDH1 ATG5_CDH1_ID2 ATG12_BNIP3_CDH1_ID2 ID2_MMP9 ATG3_CDH1_ID2 ATG12_CSE1L_CDH1_ID2 LC3_ID2 DIABLO_CDH1_ID2 ATG12_CDH1_ID2_MMP2 FRAP1_ID2 CASP8_CDH1_ID2 ATG12_CASP8_CDH1_ID2 CASP8_ID2 ATG12_ULK1_CDH1 ATG12_ATG3_CDH1_HMGB2 ID2_CIAP2 ATG12_CDH1_BECN1 ATG12_CDH1_ID2_MMP9 ID2_UVRAG ATG12_BNIP3_ID2 CDH1_ID2_HMGB2_MMP2 DIABLO_ID2 CDH1_ID2_CIAP2 ATG12_ATG3_CDH1_ID2
DRAM_CDH1 CBS_CDH1_ID2 ATG12_CASP8_CDH1_HMGB2 ID2_SIRT1 CDH1_ID2_HMGB1 ATG12_LAMP1_CDH1_ID2 FAS_ID2 CDH1_ID2_SIRT1 CDH1_ID2_AGER_BECN1 CDH1_AGER LAMP1_ID2_HMGB2 ATG12_FAS_CDH1_HMGB2 ID2_STAT3 CDH1_ID2_UVRAG ATG12_TKT_CDH1_ID2 CBS_ID2 AIFM1_LC3_CDH1 CDH1_ID2_MMP9_HMGB2 CDH1_MMP2 ATG12_CDH1_AGER ATG12_CDH1_HMGB1_HMGB2 AKT1_ID2 CDH1_ID2_STAT3 ATG12_CDH1_MMP9_HMGB2 ID2_CDH2 ATG12_LAMP1_ID2 ATG12_ATG5_CDH1_ID2 ATG7_ID2 ATG12_LC3_CDH1 ATG5_CDH1_ID2_HMGB2 ID2_HMGB1 CDH1_AGER_HMGB2 ATG3_CDH1_ID2_HMGB2 ULK1_ID2 FAS_CDH1_ID2 ATG12_DIABLO_CDH1_ID2 CDH1_LAMP2 ATG7_CDH1_ID2 CSE1L_CDH1_ID2_HMGB2 ATG5_CDH1 ATG12_CDH1_MMP2 ATG12_CDH1_CIAP2_HMGB2 ID2_SATB1 ATG12_CASP8_CDH1 ATG12_CDH1_ID2_UVRAG CDH1_MMP9 ATG12_TKT_CDH1 ATG12_CDH1_HMGB2_SESN3 ID2_RPS19BP1 BNIP3_ID2_HMGB2 LC3_CDH1_ID2_AGER ID2_TCF3 E2F1_ID2_HMGB2 ATG12_CDH1_HMGB2_SIRT1 CSE1L_CDH1 ATG12_CDH1_MMP9 ATG12_E2F1_CDH1_ID2 AIFM1_CDH1 ATG12_CDH1_SESN2 ATG12_FAS_CDH1_ID2 ID2_SESN3 CDH1_ID2_CDH2 AIFM1_ATG3_LC3_CDH1 ID2_SESN2 AKT1_CDH1_ID2 ATG12_CDH1_HMGB2_MMP2 LAMP1_CDH1 LAMP1_ID2_BECN1 BNIP3_CDH1_ID2_HMGB2 AIFM1_LC3 CDH1_ID2_TCF3 ATG12_ULK1_CDH1_HMGB2 E2F1_CDH1 ATG12_CDH1_UVRAG TKT_CDH1_ID2_HMGB2 ID2_NAMPT ATG12_FAS_CDH1 ATG12_CDH1_ID2_LAMP2 DIABLO_CDH1 LAMP1_TKT_ID2 ATG12_LC3_CDH1_ID2 BNIP3_CDH1 LAMP1_ID2_AGER ATG12_CDH1_HMGB2_UVRAG AKT1_CDH1 DRAM_LAMP1_ID2 CASP8_CDH1_ID2_HMGB2 CASP8_CDH1 ATG12_DIABLO_CDH1 DIABLO_CDH1_ID2_HMGB2 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 ATG12_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2 DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LAMP1_CDH1_ID2_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_E2F1_CDH1_ID2_HMGB2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_CDH1_ID2_HMGB2 ATG12_LC3_CDH1_ID2_AGER_HMGB2 CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_HMGB2_MMP2 ATG12_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CASP8_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_CDH1_ID2_HMGB2 ATG12_CASP8_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_HMGB2 ATG12_CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_TCF3_AGER_HMGB2 LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2 ATG12_FAS_CDH1_ID2_AGER_HMGB2 CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB1_HMGB2 CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_ATG3_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_CIAP2_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_HMGB2_UVRAG ATG12_DIABLO_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_CDH1_TCF3_HMGB2 ATG12_CASP8_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1 ATG12_DRAM_CDH1_ID2_HMGB2_MMP2 ATG12_DIABLO_CDH1_BHLHE41_HMGB2 ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_HMGB2_SESN3 ATG12_CBS_CDH1_ID2_AGER_HMGB2 ATG12_FAS_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_HMGB2
ATG3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_UVRAG CDH1_ID2_AGER_HMGB2_MMP2 ATG12_E2F1_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_TCF3_HMGB2 ATG12_ATG5_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_TCF3_AGER_HMGB2 ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3 ATG12_CDH1_ID2_HMGB1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2 AIFM1_ATG3_CASP8_LC3_CDH1 ATG12_DRAM_E2F1_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_HMGB2_SIRT1 ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_CDH1_TCF3_BECN1_HMGB2 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1 ATG12_DIABLO_CDH1_TCF3_BHLHE41 ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2 BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3 AIFM1_CASP8_DRAM_LC3_CDH1 AIFM1_ATG3_CASP8_LC3_CDH1_MMP9 ATG12_CDH1_ID2_HMGB2_LAMP2 ATG12_ATG3_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CDH1_TCF3_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_STAT3 ATG12_LC3_CDH1_ID2_HMGB2 ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2 ATG12_TKT_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2 CASP8_CDH1_ID2_AGER_HMGB2 DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_TCF3_BHLHE41_HMGB2 DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG5_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2 ATG12_CSE1L_CDH1_ID2_AGER ATG12_BNIP3_CDH1_ID2_BECN1_HMGB2 CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2 CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_LC3_CDH1_ID2_AGER_HMGB2 CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2_MMP2 AIFM1_CASP8_LC3_CDH1_MMP9 DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1 AIFM1_CASP8_DIABLO_LC3_CDH1 ATG12_TKT_CDH1_ID2_AGER_HMGB2 CDH1_ID2_AGER_HMGB1_HMGB2 DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CDH1_ID2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_MMP9_BECN1_HMGB2 ATG12_LC3_CDH1_AGER_HMGB2 CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 FAS_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3_HMGB2
七种的组合 八种的组合 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1 ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2 ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1
ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1 ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1 ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3 ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3 AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1 ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9 ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3 ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1 ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2
。
7.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A1组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表6]
一种 两种的组合 三种的组合 四种的组合 MMP2 ID2_CDH2 FRAP1_CASP3_CDH2 FRAP1_TKT_CASP3_CDH2 ID2 FRAP1_TWIST1 ID2_CDH2_SESN3 ID2_CDH2_MMP2_SESN3 TWIST1 FRAP1_CASP3 ID2_CDH2_MMP2 CBS_ID2_CDH2_SESN3 BECN1 FRAP1_SESN1 FRAP1_CDH2_TWIST1 FRAP1_TKT_CDH2_TWIST1 BAX BAX_FRAP1 FRAP1_CDH2_SESN1 FRAP1_LC3_CASP3_CDH2 BCL2L1 FRAP1_NNMT FRAP1_NNMT_CDH2 FRAP1_NNMT_TKT_CDH2 CDH2 FRAP1_CCNG2 AIFM1_FRAP1_CDH2 ID2_CDH2_RPS19BP1_SESN3 FASLG BCL2L1_FRAP1 FRAP1_TKT_TWIST1 BAX_FRAP1_TKT_CDH2 AGER FRAP1_RAGE BAX_FRAP1_CDH2 BAX_FRAP1_LC3_CDH2 ATG12 AIFM1_FRAP1 FRAP1_LC3_TWIST1 ATG12_ID2_CDH2_SESN3 TKT BCL2_FRAP1 AKT1_ID2_CDH2 ATG12_ID2_MMP2_SESN3 FRAP1_VEGF ATG12_ID2_MMP2 FRAP1_LC3_CDH2_KIAA1967 FRAP1_PTEN FRAP1_CDH2_KIAA1967 AIFM1_FRAP1_TKT_CDH2 HMGB1_TWIST1 FRAP1_CCNG2_CDH2 FRAP1_TKT_CDH2_SESN1 ATG12_ID2 FRAP1_NNMT_MMP2 ID2_MMP2_RPS19BP1_SESN3 FRAP1_RAPTOR FRAP1_CDH2_RAGE FRAP1_CDH2_SESN1_STAT3 FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1 ID2_BECN1 FRAP1_TKT_CASP3 FRAP1_LC3_NNMT_CDH2 BECN1_SESN3 ATG12_MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR ATG12_MMP2 FRAP1_CDH2_VEGF FRAP1_TKT_CCNG2_CDH2 CDH2_SESN3 ID2_CDH2_HMGB1 DIABLO_ID2_CDH2_SESN3 ID2_MMP2 FRAP1_PTEN_CDH2 ID2_CDH2_HMGB2_SESN3 FRAP1_XIAP CDH1_ID2_CDH2 FRAP1_TKT_CDH2_KIAA1967
AKT1_CDH2 FRAP1_CASP3_MMP2 FRAP1_LC3_CDH2_RAGE FRAP1_PRKAA1 FRAP1_LC3_CASP3 BAX_FRAP1_TKT_MMP2 ID2_RPS19BP1 BCL2_FRAP1_CDH2 BCL2L1_FRAP1_TKT_CDH2 TKT_MMP2 BAX_FRAP1_TKT FRAP1_CASP3_CDH2_STAT3 BAX_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_PTEN_TKT_CDH2 BECN1_FASLG BAX_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1 ATG12_SESN3 BAX_FRAP1_MMP2 ID2_CDH2_NAMPT_SESN3 CDH2_MMP2 FAS_ID2_CDH2 FRAP1_TKT_CDH2_VEGF BECN1_MMP2 FRAP1_RPS19BP1_TWIST1 FRAP1_LC3_CDH2_VEGF BAX_MMP2 FRAP1_LC3_NNMT FRAP1_NNMT_CDH2_MMP2 ID2_NAMPT FRAP1_LC3_RAGE AIFM1_FRAP1_LC3_CDH2 CASP8_ID2 FRAP1_HMGB1_TWIST1 FRAP1_LC3_PTEN_CDH2 ID2_TWIST1 FRAP1_SESN1_STAT3 FRAP1_TKT_CDH2_RAGE MMP2_SESN3 FRAP1_TKT_SESN1 FRAP1_CDH2_HMGB1_TWIST1 AKT1_BAX ATG3_ID2_CDH2 FAS_FRAP1_CDH2_SESN1 FRAP1_TP63 FRAP1_ID2_CDH2 FRAP1_CASP3_CDH2_MMP2 BAX_LC3 FRAP1_TKT_CCNG2 DRAM_ID2_CDH2_SESN3 ATG12_FASLG FAS_FRAP1_TWIST1 LC3_HMGB1_STAT3_TWIST1 LC3_TWIST1 FRAP1_NNMT_TKT CASP8_ID2_CDH2_SESN3 AKT1_TWIST1 AIFM1_FRAP1_MMP2 FRAP1_TKT_CDH2_RAPTOR ID2_FASLG ID2_CDH2_CIAP2 BCL2L1_FRAP1_LC3_CDH2 STAT3_TWIST1 FRAP1_LC3_VEGF FRAP1_CDH2_KIAA1967_MMP2 TKT_FASLG CDH2_MMP2_SESN3 FRAP1_TKT_CASP3_FASLG AKT1_ATG12 ID2_CDH2_FASLG TKT_ID2_CDH2_MMP2 MMP2_NAMPT CBS_ID2_CDH2 FRAP1_NNMT_TKT_MMP2 ID2_SIRT1 FRAP1_LC3_CCNG2 FRAP1_TKT_CASP3_MMP2 ID2_AGER BCL2L1_FRAP1_TKT ID2_CDH2_CIAP2_SESN3 ATG7_TWIST1 FRAP1_ID2_TWIST1 FRAP1_CDH2_STAT3_TWIST1 AKT1_BCL2L1 AIFM1_FRAP1_LC3 CBS_FRAP1_CASP3_CDH2 BAX_TKT AIFM1_FRAP1_TKT BAX_FRAP1_CDH2_MMP2 KIAA1967_MMP2 ATG5_ID2_CDH2 ATG12_TKT_MMP2_SESN3 BCL2L1_MMP2 FRAP1_TKT_RAGE FRAP1_CDH1_CASP3_CDH2 ATG7_TP63 BCL2L1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2 LC3_BECN1 FRAP1_CDH2_TP63 ID2_CDH2_HMGB1_MMP2 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_CDH2_STAT3_TP63 ATG12_ID2_CDH2_MMP2_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_CASP3_CDH2_STAT3 AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63 ATG12_ID2_MMP2_RPS19BP1_SESN3 AKT1_FAS_LC3_CDH2_STAT3_TP63 AKT1_FAS_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_BECN1_CDH2_STAT3_TP63 CASP8_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63 FRAP1_TKT_CASP3_CDH2_FASLG ATG12_ID2_CDH2_HMGB1_MMP2_SESN3 BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3 DIABLO_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FRAP1_LAMP1_TKT_CASP3_CDH2 ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3 CBS_ID2_CDH2_MMP2_SESN3 ATG12_ID2_CDH2_CIAP2_MMP2_SESN3 FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_TKT_CDH2_SESN1_STAT3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3 LC3_CDH2_HMGB1_STAT3_TWIST1 ATG12_FRAP1_ID2_CDH2_MMP2_SESN3 DRAM_ID2_CDH2_MMP2_SESN3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1 FRAP1_LC3_CDH2_SESN1_STAT3 ATG12_TKT_ID2_CDH2_MMP2_SESN3 CBS_FRAP1_TKT_CASP3_CDH2 ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3 ID2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ID2_CDH2_RPS19BP1_SESN3 AKT1_FAS_CASP3_CDH2_STAT3_TP63 ID2_CDH2_MMP2_NAMPT_SESN3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3 AKT1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR ATG12_ID2_CDH2_MMP2_SESN3_STAT3
FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_NNMT_TKT_BECN1_CDH2_STAT3 BAX_FRAP1_TKT_CDH2_MMP2 ATG12_FAS_FRAP1_CDH2_STAT3_TP63 FAS_FRAP1_LC3_CDH2_KIAA1967 ATG12_ATG3_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_CDH2_RPS19BP1_TP63 DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_RAGE ATG12_CBS_ID2_CDH2_MMP2_SESN3 FAS_LC3_HMGB1_STAT3_TWIST1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3 FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CASP3_CDH2_CIAP2 AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3 TKT_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_TKT_CDH2_KIAA1967_MMP2 ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CDH2_HMGB1_TWIST1 AKT1_FAS_CDH2_HMGB1_STAT3_TP63 BAX_FRAP1_LC3_BECN1_CDH2 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CDH2_STAT3_TWIST1 ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_ID2_CDH2_SESN3 FRAP1_LC3_NNMT_TKT_CDH2_STAT3 BAX_FAS_FRAP1_LC3_CDH2 CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3 ATG12_CBS_ID2_MMP2_SESN3 AKT1_ATG12_CDH2_HMGB1_STAT3_TP63 FAS_FRAP1_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 FRAP1_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_TKT_CDH2_SESN1 ATG12_ATG5_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_CCNG2_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_STAT3_TP63 ID2_CDH2_MMP2_SESN3_UVRAG AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63 ATG7_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR ID2_CDH2_HMGB1_RPS19BP1_SESN3 FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CDH2_MMP2_RAPTOR ATG12_CDH1_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_TKT_CDH2_STAT3_TWIST1 ATG12_ID2_CDH2_FASLG_SESN3 CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3 ATG7_FRAP1_TKT_CASP3_CDH2 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1 FRAP1_TKT_CASP3_CDH2_MMP2 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_TWIST1 ATG12_ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CDH2_KIAA1967 ATG12_FAS_ID2_CDH2_MMP2_SESN3 ATG7_ID2_CDH2_RPS19BP1_TP63 TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3 BAX_FRAP1_TKT_BECN1_CDH2 BAX_FAS_FRAP1_LC3_TKT_CDH2 ATG3_FRAP1_TKT_CASP3_CDH2 ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2 CDH1_ID2_MMP9_TCF3_CDH2_SESN3
七种的组合 八种的组合 AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63 AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63
AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63 AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63 FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STAT3_TP63 ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_CASP8_FAS_NNMT_CDH2_STAT3_TP63 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_CIAP2_STAT3_TP63 CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3
。
8.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A2组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表7]
一种 两种的组合 三种的组合 四种的组合 TKT PRKAA1_LAMP2 LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1 SESN2 TKT_SESN2 BNIP3_PRKAA1_LAMP2 ATG3_LC3_SESN2_SIRT1 LAMP2 ATG7_LAMP2 ATG5_LC3_SESN2 CSE1L_LC3_SESN2_SIRT1 LAMP2_SESN2 BNIP3_LC3_SESN2 ATG5_CSE1L_LC3_SESN2 AKT1_PRKAA1 ATG7_LC3_SESN2 BNIP3_LC3_SESN2_SIRT1 SESN2_SIRT1 AKT1_PRKAA1_LAMP2 FRAP1_LC3_SESN2_SIRT1 TKT_VEGF ATG7_TKT_SESN2 AKT1_ATG3_PRKAA1_LAMP2 ATG7_TKT DRAM_LC3_SESN2 ATG3_ATG5_LC3_SESN2 TKT_LAMP2 PRKAA1_AGER_LAMP2 ATG7_LC3_SESN2_SIRT1 BHLHE41_SESN2 PRKAA1_TKT_LAMP2 BNIP3_CSE1L_LC3_SESN2 TKT_BHLHE41 ATG7_TKT_LAMP2 TKT_LAMP2_SESN2_SIRT1 ATG5_SESN2 TKT_LAMP2_SESN2 CIAP2_LAMP2_SESN2_SIRT1 LAMP1_SESN2 TKT_LAMP2_VEGF ATG12_TKT_LAMP2_SESN2 CSE1L_LAMP2 ATG12_LC3_SESN2 ATG7_TKT_LAMP2_SESN2 ATG12_SESN2 ATG7_LAMP2_SESN2 AKT1_ATG7_PRKAA1_LAMP2 AKT1_TKT TKT_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2 E2F1_SESN2 E2F1_LC3_SESN2 ATG3_BNIP3_LC3_SESN2 ATG3_LAMP2 LC3_SESN2_UVRAG AKT1_PRKAA1_LAMP2_UVRAG BNIP3_SESN2 PRKAA1_CCNG2_LAMP2 DRAM_LC3_SESN2_SIRT1
LC3_SESN2 AKT1_ATG7_TKT ATG7_CSE1L_LC3_SESN2 TWIST1_VEGF ATG5_PRKAA1_LAMP2 ATG7_FRAP1_LC3_SESN2 ATG7_LC3 ATG3_LAMP2_SESN2 BNIP3_PRKAA1_LAMP2_SESN2 CSE1L_SESN2 BNIP3_TKT_SESN2 ATG5_ATG7_LC3_SESN2 ATG5_LC3 LAMP2_SESN2_SIRT1 PRKAA1_TKT_LAMP2_SESN2 ATG7_SESN2 ATG7_PRKAA1_LAMP2 ATG3_ATG7_LC3_SESN2 LC3_ULK1 LAMP1_LC3_SESN2 BNIP3_PRKAA1_AGER_LAMP2 ATG3_TKT ATG12_PRKAA1_LAMP2 E2F1_LC3_SESN2_SIRT1 DRAM_SESN2 CASP8_PRKAA1_LAMP2 LC3_ID2_SESN2_SIRT1 PRKAA1_TKT AIFM1_TKT_SESN2 LC3_NAMPT_SESN2_SIRT1 BHLHE41_LAMP2 FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2 LAMP2_VEGF PRKAA1_HMGB1_LAMP2 ATG7_BNIP3_LC3_SESN2 AKT1_VEGF LC3_BHLHE41_SESN2 LC3_RPS19BP1_SESN2_SIRT1 TKT_CIAP2 ATG12_TKT_SESN2 AKT1_ATG7_TKT_SESN2 CSE1L_BHLHE41 CSE1L_LAMP2_SESN2 BCL2L1_BNIP3_PRKAA1_LAMP2 LC3_BHLHE41 PRKAA1_CASP3_LAMP2 CSE1L_DRAM_LC3_SESN2 LC3_SIRT1 PRKAA1_LAMP2_RAGE DIABLO_LC3_SESN2_SIRT1 CSE1L_LAMP1 PRKAA1_LAMP2_SESN2 LC3_SESN2_SIRT1_STAT3 TKT_RPS19BP1 TKT_CIAP2_SESN2 ATG12_ATG5_LC3_SESN2 CBS_TKT BCL2L1_PRKAA1_LAMP2 BNIP3_PRKAA1_TCF3_LAMP2 CSE1L_BECN1 DIABLO_PRKAA1_LAMP2 LC3_SESN2_SIRT1_UVRAG TKT_CDH1 PRKAA1_CDH1_LAMP2 BNIP3_PRKAA1_MMP9_LAMP2 TKT_HMGB1 CBS_PRKAA1_LAMP2 AKT1_LC3_SESN2_SIRT1 TKT_RAGE CSE1L_SESN2_SIRT1 AKT1_PRKAA1_CDH1_LAMP2 AIFM1_SESN2 ATG3_PRKAA1_LAMP2 CSE1L_LAMP1_LC3_SESN2 ATG7_TWIST1 PRKAA1_FASLG_LAMP2 ATG7_PRKAA1_TKT_LAMP2 BHLHE41_NAMPT PRKAA1_ID2_LAMP2 KIAA1967_LAMP2_SESN2_SIRT1 BNIP3_LC3 PRKAA1_LAMP2_SATB1 LC3_SESN2_SESN3_SIRT1 PRKAA1_SESN2 PRKAA1_LAMP2_SESN1 BNIP3_PRKAA1_HMGB1_LAMP2 ATG7_NAMPT AKT1_ATG7_PTEN CSE1L_LC3_SESN2_UVRAG BECN1_SESN2 ATG7_TKT_BHLHE41 LC3_MMP9_SESN2_SIRT1 TKT_HMGB2 PRKAA1_LAMP2_MMP2 ATG3_LAMP2_SESN2_SIRT1 TKT_SIRT1 CSE1L_LAMP1_SESN2 BNIP3_PRKAA1_CCNG2_LAMP2 ATG5_CSE1L PRKAA1_LAMP2_SESN3 BNIP3_PRKAA1_LAMP2_SATB1 SESN2_UVRAG ATG3_TKT_SESN2 BNIP3_PRKAA1_LAMP2_SESN1 TKT_CASP3 ATG5_CSE1L_SESN2 ATG5_DRAM_LC3_SESN2 TKT_CDH2 ATG5_CSE1L_LC3 BNIP3_PRKAA1_CASP3_LAMP2 TKT_MMP2 FRAP1_PRKAA1_LAMP2 BNIP3_FRAP1_LC3_SESN2
五种的组合 六种的组合 CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_LC3_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_FRAP1_LC3_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 TKT_CIAP2_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 TKT_CDH1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_BNIP3_LC3_SESN2_SIRT1 ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_CSE1L_LC3_SESN2_SIRT1 FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_LC3_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 BNIP3_FRAP1_LC3_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BNIP3_PRKAA1_TKT_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2_SIRT1 ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_ATG7_LC3_SESN2_SIRT1 BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_TKT_LAMP2_SESN2 CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1 AKT1_ATG7_BNIP3_PRKAA1_LAMP2 ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_SESN2_SIRT1 CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_BNIP3_LC3_SESN2 FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1
BNIP3_CSE1L_LC3_SESN2_SIRT1 MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_DRAM_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 AIFM1_CIAP2_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_TKT_LAMP2_SESN2_SIRT1 CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2 LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_LC3_NAMPT_SESN2_SIRT1 TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_E2F1_LC3_SESN2_SIRT1 ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1 ATG7_LC3_LAMP2_SESN2_SIRT1 ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1 AIFM1_BNIP3_PRKAA1_LAMP2_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG12_BNIP3_TKT_LAMP2_SESN2 ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_KIAA1967_LAMP2_SESN2_SIRT1 E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG12_ATG5_BNIP3_LC3_SESN2 ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_LAMP2_SESN2 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG12_TKT_CIAP2_LAMP2_SESN2 ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_BNIP3_CSE1L_LC3_SESN2 TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1 AKT1_ATG7_PRKAA1_TKT_LAMP2 ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_LC3_NAMPT_SESN2_SIRT1 ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1 ATG3_CSE1L_LC3_SESN2_SIRT1 AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_LC3_ID2_SESN2_SIRT1 CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1 BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_ID2_SESN2_SIRT1 ATG3_LC3_ID2_SESN2_SIRT1 AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_TKT_LAMP2_SESN2_SIRT1 ATG3_ATG5_E2F1_LC3_SESN2_SIRT1 LC3_CIAP2_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1 ATG12_TKT_CDH1_LAMP2_SESN2 ATG3_ATG5_LC3_SESN2_SIRT1_STAT3 ATG5_LC3_SESN2_SIRT1_STAT3 AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG ATG3_DRAM_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1 ATG5_DIABLO_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1 ATG7_BNIP3_LC3_SESN2_SIRT1 ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1 CDH2_CIAP2_LAMP2_SESN2_SIRT1 TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2 ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1 DRAM_TKT_LAMP2_SESN2_SIRT1 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG12_ATG3_TKT_LAMP2_SESN2 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1_UVRAG AIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合 八种的组合 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3 CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1 ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1
AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1 BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3 ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 C IAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN1_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1 AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1 ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1 LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1
。
9.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A2组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表8]
一种 两种的组合 三种的组合 四种的组合 BCL2L1 BCL2L1_NNMT BCL2L1_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1 FAS BCL2L1_E2F1 BCL2L1_E2F1_PRKAA1 BCL2L1_TKT_CASP3_SESN2 LAMP1 BCL2L1_TKT ATG3_BCL2L1_PRKAA1 BCL2L1_ID2_CASP3_SESN2 BHLHE41 FAS_LAMP1 ATG3_BCL2L1_NNMT ATG3__BCL2L1__E2F1_PRKAA1 TKT BCL2L1_PRKAA1 ATG3_BCL2L1_E2F1 BCL2L1_NNMT_PRKAA1_HMGB1 LC3 FAS_BHLHE41 FAS_BHLHE41_SESN2 BCL2L1_NNMT_PRKAA1_MMP2 SESN2 FAS_TKT BCL2L1_PRKAA1_HMGB2 BCL2L1_NNMT_PRKAA1_CDH1 BCL2L1_CASP3 BCL2L1_CASP3_SESN2 FAS_TKT_CASP3_SESN2 ATG3_BCL2L1 BCL2L1_PRKAA1_TKT BCL2L1_NNMT_PRKAA1_VEGF ATG7_BCL2L1 FAS_CASP3_SESN2 ATG7_BCL2L1_NNMT_PRKAA1 FAS_CASP3 BCL2L1_TKT_CASP3 BCL2L1_FRAP1_NNMT_PRKAA1 TKT_BHLHE41 FAS_TKT_CASP3 BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_KIAA1967 BCL2L1_E2F1_TKT AIFM1_BCL2L1_NNMT_PRKAA1 FAS_PRKAA1 BCL2L1_NNMT_TKT BCL2L1_TKT_BHLHE41_CASP3 FAS_KIAA1967 FAS_TKT_BHLHE41 BCL2L1_NNMT_PRKAA1_CDH2
FAS_SESN2 FAS_TKT_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1 BCL2L1_HMGB2 FAS_LAMP1_BHLHE41 BCL2L1_NNMT_PRKAA1_HMGB2 BCL2L1_VEGF FAS_LAMP1_SESN2 BCL2L1_CBS_NNMT_PRKAA1 BNIP3_FAS ATG3_BCL2L1_TKT FAS_TKT_SESN2_TP63 FAS_TWIST1 ATG7_BCL2L1_PRKAA1 BCL2L1_DRAM_NNMT_PRKAA1 BNIP3_TKT DIABLO_FAS_BHLHE41 BCL2L1_NNMT_PRKAA1_ULK1 BCL2L1_CSE1L TKT_SESN2_TP63 BNIP3_TKT_CASP3_SESN2 TKT_SESN2 FAS_PRKAA1_TKT ATG5_BCL2L1_NNMT_PRKAA1 BCL2L1_FRAP1 ATG7_BCL2L1_NNMT BCL2L1_DIABLO_NNMT_PRKAA1 LAMP1_SESN2 BCL2L1_BNIP3_TKT BCL2L1_NNMT_CASP3_SESN2 LC3_BHLHE41 BNIP3_FAS_TKT FAS_TKT_BHLHE41_CASP3 BCL2L1_BNIP3 BCL2L1_NNMT_CASP3 BCL2L1_NNMT_PRKAA1_TKT BCL2L1_LC3 TKT_BHLHE41_CASP3 BNIP3_FAS_TKT_CASP3 ATG5_BCL2L1 ATG3_BCL2L1_CASP3 ATG3_ATG7_BCL2L1_PRKAA1 BCL2L1_CBS BCL2L1_PRKAA1_CASP3 FAS_ID2_CASP3_SESN2 CSE1L_LAMP1 BCL2L1_PRKAA1_MMP2 BCL2L1_NNMT_PRKAA1_CASP3 E2F1_FAS FAS_BHLHE41_CASP3 ATG3_BCL2L1_PRKAA1_HMGB2 AIFM1_BCL2L1 FAS_TKT_KIAA1967 FAS_LC3_BHLHE41_SESN2 BHLHE41_SESN2 FAS_TKT_TWIST1 ATG3_BCL2L1_BNIP3_NNMT CASP8_FAS BCL2L1_E2F1_NNMT BCL2L1_CASP8_NNMT_PRKAA1 FAS_NAMPT BCL2L1_FRAP1_NNMT FAS_BHLHE41_CASP3_SESN2 FAS_TP63 BCL2L1_TKT_BHLHE41 BCL2L1_BNIP3_NNMT_TKT LAMP1_BHLHE41 BCL2L1_TKT_SESN2 DIABLO_FAS_BHLHE41_SESN2 ATG12_FAS FAS_KIAA1967_SESN2 ATG3_BCL2L1_PRKAA1_TKT BCL2L1_MMP2 DIABLO_FAS_LAMP1 BCL2L1_NNMT_PRKAA1_MMP9 BHLHE41_CASP3 ATG3_BCL2L1_KIAA1967 BNIP3_FAS_CASP3_SESN2 FAS_HMGB1 ATG7_BCL2L1_E2F1 FAS_LAMP1_BHLHE41_SESN2 FAS_VEGF FAS_BHLHE41_SATB1 BCL2L1_CASP3_SESN1_SESN2 LAMP1_TCF3 ATG3_ATG7_BCL2L1 BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_ULK1 ATG7_BCL2L1_TKT DIABLO_FAS_LAMP1_BHLHE41 FAS_LC3 BCL2L1_BNIP3_NNMT FAS_TKT_CASP3_SIRT1 NNMT_BHLHE41 BCL2L1_PRKAA1_VEGF E2F1_FAS_BHLHE41_SESN2 BCL2L1_FAS BCL2L1_BHLHE41_CASP3 FAS_TKT_CASP3_FASLG TKT_TP63 FAS_SESN2_TP63 FAS_TKT_HMGB1_SESN2 AKT1_BCL2L1 TKT_BHLHE41_TP63 FAS_CASP3_HMGB1_SESN2 ATG12_BCL2L1 AIFM1_BCL2L1_NNMT BAX_BCL2L1_NNMT_PRKAA1 FAS_HMGB2 BCL2L1_CSE1L_NNMT BCL2L1_E2F1_NNMT_PRKAA1 BCL2L1_ID2 BCL2L1_E2F1_FRAP1 ATG3_BCL2L1_PRKAA1_MMP2 BCL2L1_RPS19BP1 BNIP3_FAS_CASP3 FAS_TKT_KIAA1967_SESN2 TKT_SATB1 FAS_TKT_SATB1 BNIP3_FAS_TKT_TWIST1 FAS_XIAP BCL2L1_CSE1L_PRKAA1 ATG3_BCL2L1_BNIP3_TKT BCL2_BCL2L1 BCL2L1_NNMT_VEGF BCL2L1_NNMT_PRKAA1_PTEN
五种的组合 六种的组合 BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1 ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2 BCL2L1_TKT_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN2 FAS_TKT_CASP3_HMGB1_SESN2_TP63 ATG3_BCL2L1_NNMT_PRKAA1_CDH1 ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1 BCL2L1_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ULK1 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF FAS_TKT_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2 FAS_TKT_CASP3_SESN2_TP63 BCL2L1_NNMT_ID2_AGER_CASP3_SESN2 ATG3_BCL2L1_FRAP1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2 FAS_TKT_HMGB1_SESN2_TP63 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2 AIFM1_ATG3_BCL2L1_NNMT_PRKAA1 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_ID2_CASP3_SESN1_SESN2 ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2
ATG3_BCL2L1_NNMT_PRKAA1_MMP2 BNIP3_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_TKT_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_VEGF AIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_TKT_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2 BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG BCL2L1_NNMT_PRKAA1_HMGB1_VEGF BCL2L1_NNMT_ID2_CASP3_SESN2_SESN3 ATG3_BCL2L1_NNMT_PRKAA1_CDH2 BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_LAMP1_NNMT_PRKAA1 BAX_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_SESN2_UVRAG BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2 ATG3_BCL2L1_CBS_NNMT_PRKAA1 BNIP3_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2 BNIP3_FAS_TKT_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2 ATG3_BCL2L1_DRAM_NNMT_PRKAA1 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2 ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_FAS_TKT_CASP3_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2 ATG3_BCL2L1_CSE1L_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF ATG3_BCL2L1_DIABLO_NNMT_PRKAA1 BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_CASP8_ID2_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_DIABLO_ID2_CASP3_SESN2 BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2 BCL2L1_TKT_CASP3_SESN2_STAT3 BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_VEGF BCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2 BCL2L1_ID2_CASP3_HMGB2_SESN2 BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_CASP3_SESN2_SESN3 BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2 BCL2L1_TKT_CASP3_CCNG2_SESN2 BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2 FAS_TKT_CASP3_FASLG_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2 FAS_TKT_CASP3_SESN2_SIRT1 BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2 BCL2L1_NNMT_ID2_KIAA1967_SESN2 BNIP3_FAS_TKT_CASP3_HMGB1_SESN2 ATG5_BCL2L1_ID2_CASP3_SESN2 FAS_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG BCL2L1_TKT_XIAP_BHLHE41_CASP3 FAS_TKT_HMGB1_KIAA1967_SESN2_TP63 FAS_TKT_XIAP_CASP3_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_CDH1_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_ID2_CASP3_SESN2 BCL2L1_TKT_CASP3_SESN2_SIRT1 BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2 ATG7_BCL2L1_NNMT_PRKAA1_ID2 BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2_BCL2L1_TKT_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_ID2_CASP3_CDH2_SESN2 BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2
七种的组合 八种的组合 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2 BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2
BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3 ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2 BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2 BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2 BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2 BCL2L1_NNMT_ID2_AGER_CASP3_RAGE_SESN2 AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967 BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2 BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2 BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2
。
10.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测A2组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表9]
一种 两种的组合 三种的组合 四种的组合 SESN2 TKT_SESN2 ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2 TKT BHLHE41_SESN2 FRAP1_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1 LAMP2 LAMP2_SESN2 ATG5_LC3_SESN2 ATG7_TKT_LAMP2_SESN2 BHLHE41 ATG5_SESN2 ATG5_FRAP1_SESN2 ATG5_FRAP1_SESN2_SIRT1 CSE1L LAMP1_SESN2 TKT_LAMP2_SESN2 AKT1_ATG7_TKT_SESN2 SESN2_SIRT1 AIFM1_TKT_SESN2 ATG5_CSE1L_LC3_SESN2 E2F1_SESN2 ATG5_CSE1L_SESN2 FRAP1_LC3_SESN2_SIRT1 ATG12_SESN2 LC3_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_SESN2 TKT_VEGF ATG12_TKT_SESN2 ATG7_TKT_SESN2_SESN3 CSE1L_BECN1 CSE1L_LAMP1_SESN2 ATG5_FRAP1_LC3_SESN2 CSE1L_SESN2 TKT_HMGB2_SESN2 ATG7_CSE1L_FRAP1_SESN2 ATG7_TKT ATG5_TKT_SESN2 CSE1L_LC3_SESN2_SIRT1
FASLG_SESN2 TKT_CDH1_SESN2 ATG5_LC3_SESN2_SIRT1 PRKAA1_LAMP2 TKT_SESN2_SESN3 ATG7_TKT_FASLG_SESN2 PRKAA1_SESN2 TKT_SESN2_VEGF ATG7_TKT_AGER_SESN2 TKT_BHLHE41 CSE1L_BHLHE41_SESN2 ATG7_TKT_HMGB1_SESN2 CSE1L_BHLHE41 PRKAA1_TKT_SESN2 ATG7_TKT_MMP2_SESN2 ATG7_SESN2 ATG3_TKT_SESN2 BNIP3_CSE1L_FRAP1_SESN2 CSE1L_LAMP2 TKT_RPS19BP1_SESN2 ATG5_ATG7_TKT_SESN2 FAS_SESN2 CBS_TKT_SESN2 ATG7_BCL2_TKT_SESN2 HMGB2_SESN2 CSE1L_LAMP2_SESN2 ATG7_BNIP3_TKT_SESN2 CSE1L_LAMP1 TKT_SESN2_SIRT1 FAS_FRAP1_SESN2_SIRT1 BECN1_SESN2 AKT1_TKT_SESN2 AIFM1_ATG7_TKT_SESN2 NNMT_SESN2 CSE1L_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2 AIFM1_SESN2 TKT_CDH2_SESN2 ATG7_TKT_BHLHE41_SESN2 BAX_SESN2 BNIP3_TKT_SESN2 ATG7_TKT_ID2_SESN2 DRAM_SESN2 NNMT_TKT_SESN2 CSE1L_DRAM_FRAP1_SESN2 CSE1L_ULK1 TKT_AGER_SESN2 CSE1L_FRAP1_SESN2_UVRAG KIAA1967_SESN2 TKT_BHLHE41_SESN2 ATG7_LAMP1_TKT_SESN2 SESN2_VEGF TKT_HMGB1_SESN2 ATG7_BCL2L1_TKT_SESN2 BNIP3_SESN2 TKT_MMP2_SESN2 ATG7_TKT_CCNG2_SESN2 SESN2_UVRAG E2F1_TKT_SESN2 CSE1L_E2F1_FRAP1_SESN2 TWIST1_VEGF NAMPT_SESN2_SIRT1 CSE1L_LAMP1_LC3_SESN2 PRKAA1_FASLG TKT_KIAA1967_SESN2 PRKAA1_TKT_LAMP2_SESN2 TKT_RPS19BP1 DRAM_TKT_SESN2 ATG7_CBS_TKT_SESN2 PRKAA1_TKT TKT_CIAP2_SESN2 ATG7_LC3_TKT_SESN2 ATG7_LAMP2 TKT_MMP9_SESN2 ATG7_NNMT_TKT_SESN2 AGER_SESN2 ATG5_NAMPT_SESN2 ATG7_TKT_CIAP2_SESN2 CDH2_SESN2 ATG7_FRAP1_SESN2 ATG7_TKT_SESN2_STAT3 AKT1_PRKAA1 CSE1L_E2F1_SESN2 ATG7_PTEN_TKT_SESN2 ULK1_SESN2 LAMP1_TKT_SESN2 ATG7_TKT_CASP3_SESN2 MMP2_SESN2 LC3_TKT_SESN2 ATG7_TKT_CDH2_SESN2 ATG5_CSE1L TKT_CASP3_SESN2 ATG7_TKT_HMGB2_SESN2 HMGB1_SESN2 TKT_CCNG2_SESN2 ATG7_TKT_NAMPT_SESN2 AKT1_TKT TKT_ID2_SESN2 ATG7_TKT_RAPTOR_SESN2 CBS_SESN2 TKT_RAPTOR_SESN2 ATG7_TKT_SESN2_SIRT1 FRAP1_SESN2 TKT_XIAP_SESN2 ATG7_FRAP1_LC3_SESN2 CIAP2_SESN2 BAX_TKT_SESN2 ATG7_TKT_BECN1_SESN2 BCL2_SESN2 BCL2_TKT_SESN2 ATG7_DIABLO_TKT_SESN2 CCNG2_SESN2 ATG12_CSE1L_SESN2 ATG7_FRAP1_SESN2_SIRT1 BCL2L1_SESN2 BCL2L1_TKT_SESN2 ATG12_CSE1L_FRAP1_SESN2 CSE1L_UVRAG CASP8_TKT_SESN2 ATG7_TKT_XIAP_SESN2 RAPTOR_SESN2 DIABLO_TKT_SESN2 ATG7_E2F1_TKT_SESN2 XIAP_SESN2 FAS_BHLHE41_SESN2 ATG7_TKT_MMP9_SESN2 CASP3_SESN2 FRAP1_TKT_SESN2 ATG7_TKT_RAGE_SESN2 CASP8_SESN2 PTEN_TKT_SESN2 ATG3_ATG7_TKT_SESN2 LC3_SESN2 TKT_RAGE_SESN2 ATG7_CSE1L_LC3_SESN2
五种的组合 六种的组合 ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AKT1_ATG7_TKT_LAMP2_SESN2 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG5_FRAP1_LAMP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 CSE1L_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2 ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG5_CSE1L_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3
CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG7_TKT_LAMP2_SESN2_SESN3 AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_SATB1_SESN2_SIRT1 ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_CDH1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG7_TKT_FASLG_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_ID2_SESN2 CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_SESN2_SESN3 CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG7_TKT_LAMP2_MMP2_SESN2 CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_CSE1L_FRAP1_SESN2_SIRT1 AKT1_ATG5_FRAP1_LC3_SESN2_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3 ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_SESN2 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 CSE1L_DRAM_FRAP1_LC3_SESN2 ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_FAS_FRAP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 CSE1L_FRAP1_SESN2_SESN3_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_DRAM_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_DIABLO_FRAP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2 ATG7_CSE1L_FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 ATG5_CSE1L_FRAP1_CDH1_SESN2 ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1 ATG7_TKT_FASLG_SESN2_SESN3 ATG5_CSE1L_FRAP1_CDH1_SESN2_SIRT1 ATG7_TKT_HMGB1_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG7_TKT_AGER_LAMP2_SESN2 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_FRAP1_SESN2_SIRT1 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SATB1_SESN2 ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_ID2_SESN2_SIRT1 CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG7_BNIP3_TKT_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3 ATG5_ATG7_CSE1L_FRAP1_SESN2 AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2 ATG5_LC3_NAMPT_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG ATG12_ATG5_CSE1L_FRAP1_SESN2 CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1_STAT3 CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_UVRAG ATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2 AKT1_ATG7_TKT_MMP2_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG5_BNIP3_CSE1L_FRAP1_SESN2 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2 CSE1L_FRAP1_MMP9_SESN2_SIRT1 CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 BNIP3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2 AKT1_ATG7_TKT_HMGB1_SESN2 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_AKT1_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1 AKT1_ATG5_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1 ATG12_ATG7_TKT_LAMP2_SESN2 ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1 CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合 八种的组合 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAG
AKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2 ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG AIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAG ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1 ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1_UVRAG ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1 ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1 AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG7_TKT_CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1
。
11.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测B组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表10]
一种 两种的组合 三种的组合 四种的组合 HMGB1 ATG3_HMGB1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1 TKT ATG3_BECN1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG TKT_HMGB1 ATG3_TKT_HMGB1 ATG3_BCL2_TKT_HMGB1 BCL2L1_TKT ATG3_CDH1_HMGB1 ATG3_BCL2_HMGB1_RAGE ATG3_NAMPT ATG3_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2 BCL2_HMGB1 ATG3_HMGB1_UVRAG ATG3_CDH1_HMGB1_SIRT1 HMGB1_TWIST1 ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_MMP2 ATG12_ATG3 ATG3_HMGB1_SIRT1 ATG3_HMGB1_HMGB2_RAGE CSE1L_DIABLO ATG3_BECN1_SATB1 ATG3_BCL2_BNIP3_HMGB1
ATG3_TKT ATG3_HMGB1_SATB1 ATG3_CDH1_CASP3_HMGB1 LAMP1_HMGB1 ATG3_LC3_BECN1 ATG3_CDH1_HMGB1_KIAA1967 TKT_BECN1 ATG3_HMGB1_LAMP2 ATG3_HMGB1_RAGE_UVRAG CDH1_HMGB1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_RAGE_SIRT1 HMGB1_TP63 ATG3_HMGB1_KIAA1967 ATG3_TKT_HMGB1_HMGB2 TKT_NAMPT BCL2L1_TKT_CASP3 ATG3_TKT_HMGB1_UVRAG BCL2_TKT ATG12_ATG3_HMGB1 ATG3_BCL2_LAMP1_HMGB1 CSE1L_TKT BCL2L1_TKT_SIRT1 ATG3_BCL2_HMGB1_RAPTOR LC3_TKT ATG3_CIAP2_HMGB1 AIFM1_ATG3_BCL2_HMGB1 TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_CASP3_HMGB1_RAGE FASLG_HMGB1 BCL2_TKT_HMGB1 ATG12_ATG3_HMGB1_RAGE CDH2_HMGB1 ATG3_BECN1_SESN3 ATG3_TKT_CASP3_HMGB1 ATG5_HMGB1 ATG3_CASP8_HMGB1 ATG3_TKT_HMGB1_KIAA1967 HMGB1_SIRT1 ATG3_CDH2_HMGB1 ATG3_BCL2L1_TKT_BECN1 ATG12_HMGB1 ATG3_FRAP1_HMGB1 ATG12_ATG3_CDH1_HMGB1 HMGB1_RAGE ATG3_BNIP3_HMGB1 ATG3_CDH1_HMGB1_RAGE HMGB1_UVRAG ATG3_BECN1_HMGB1 ATG3_BCL2_FRAP1_HMGB1 BCL2L1_SIRT1 ATG3_CBS_HMGB1 ATG3_BCL2_HMGB1_LAMP2 ATG3_TCF3 AIFM1_ATG3_HMGB1 ATG3_BCL2_DIABLO_HMGB1 BCL2L1_HMGB1 ATG3_HMGB1_STAT3 ATG3_TKT_HMGB1_SIRT1 TKT_SIRT1 ATG3_HMGB1_MMP2 ATG3_BCL2_CBS_HMGB1 HMGB1_LAMP2 ATG3_LAMP1_HMGB1 ATG3_BCL2_CASP8_HMGB1 TKT_SESN2 BCL2L1_TKT_FASLG ATG3_HMGB1_HMGB2_SATB1 HMGB1_MMP2 ATG3_DIABLO_HMGB1 ATG3_BCL2_PTEN_HMGB1 TKT_AGER BCL2_BCL2L1_TKT ATG3_HMGB1_RAGE_RAPTOR HMGB1_RAPTOR TKT_HMGB1_TWIST1 ATG3_TKT_HMGB1_RAGE E2F1_HMGB1 ATG3_NNMT_HMGB1 ATG3_BCL2_CASP3_HMGB1 CASP8_HMGB1 ATG3_MMP9_HMGB1 ATG3_BCL2_HMGB1_SATB1 TKT_ID2 BCL2L1_TKT_HMGB1 ATG3_HMGB1_LAMP2_RAGE AKT1_TKT ATG3_LAMP1_BECN1 ATG3_CDH1_HMGB1_LAMP2 ATG3_SIRT1 ATG3_BCL2L1_BECN1 ATG3_HMGB1_HMGB2_UVRAG TKT_RPS19BP1 ATG5_TKT_HMGB1 ATG3_BCL2L1_TKT_HMGB1 CSE1L_HMGB1 ATG3_FASLG_HMGB1 CDH1_HMGB1_TP63_UVRAG BCL2L1_BECN1 ATG3_MMP9_BECN1 ATG3_CDH1_HMGB1_HMGB2 CASP3_HMGB1 ATG3_ATG7_BECN1 ATG3_BCL2L1_TKT_CASP3 ATG7_HMGB1 ATG3_HMGB1_SESN3 ATG3_HMGB1_KIAA1967_RAGE FRAP1_HMGB1 ATG3_E2F1_HMGB1 ATG3_BCL2_DRAM_HMGB1 HMGB1_HMGB2 HMGB1_RAPTOR_TWIST1 ATG3_LC3_TKT_HMGB1 HMGB1_SATB1 AKT1_ATG3_BECN1 ATG3_BCL2_HMGB1_UVRAG ATG3_ULK1 ATG3_FAS_HMGB1 ATG3_CDH1_CDH2_HMGB1 ATG3_SESN1 ATG3_ULK1_HMGB1 BCL2_BCL2L1_TKT_CASP3 CBS_HMGB1 TKT_HMGB1_SIRT1 ATG3_TKT_BECN1_HMGB1 TKT_KIAA1967 ATG3_BAX_HMGB1 ATG3_TKT_HMGB1_LAMP2 ATG12_BCL2L1 TKT_CDH2_HMGB1 ATG3_BCL2_PRKAA1_HMGB1 DRAM_HMGB1 ATG3_PTEN_HMGB1 BCL2L1_TKT_CASP3_SIRT1 LC3_FASLG ATG3_TKT_BECN1 BCL2L1_TKT_CASP3_FASLG HMGB1_KIAA1967 ATG3_HMGB1_TWIST1 BCL2L1_TKT_CASP3_CDH2 TKT_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2_NNMT_HMGB1
五种的组合 六种的组合 ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG
ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2 ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967 ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2 ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967 ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1 ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1 ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1 ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3 ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1 ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1 ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1
ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1 ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG
。
12.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测B组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表11]
一种 两种的组合 三种的组合 四种的组合 ATG12 DIABLO_NAMPT DIABLO_ID2_NAMPT ATG12_ID2_MMP9_TCF3 DIABLO ATG12_ID2 DIABLO_FAS_NAMPT DIABLO_FAS_ID2_NAMPT UVRAG ATG12_RPS19BP1 ATG12_ID2_TCF3 ATG12_CSE1L_ID2_MMP9 NAMPT ATG12_DIABLO DIABLO_FAS_STAT3 DIABLO_ID2_MMP9_NAMPT STAT3 ID2_NAMPT ATG12_ID2_MMP9 DIABLO_FAS_MMP9_NAMPT E2F1 DIABLO_STAT3 ATG12_ID2_SATB1 DIABLO_ID2_NAMPT_STAT3
BECN1 DIABLO_FAS ATG12_ID2_RPS19BP1 ATG12_FAS_ID2_MMP9 FRAP1 ATG12_CSE1L ATG12_CSE1L_ID2 ATG12_ID2_MMP9_SATB1 ATG7 ATG12_MMP9 ATG12_DIABLO_FAS DIABLO_ID2_NAMPT_SATB1 ID2 ATG12_ATG3 ATG12_ID2_SESN2 ATG12_ID2_MMP9_SESN2 SIRT1 ATG12_SATB1 ATG12_ID2_NAMPT ATG12_ID2_MMP9_RPS19BP1 BCL2 ATG12_SESN2 ATG12_CSE1L_DIABLO CSE1L_DIABLO_ID2_NAMPT BNIP3 CSE1L_DIABLO ID2_NAMPT_STAT3 DIABLO_ID2_TCF3_NAMPT LAMP2 ATG12_TCF3 ATG12_ID2_BHLHE41 DIABLO_FAS_NAMPT_SATB1 TKT ATG12_FAS CSE1L_DIABLO_NAMPT ATG12_DIABLO_FAS_MMP9 ATG12_STAT3 DIABLO_LC3_NAMPT DIABLO_FAS_ID2_STAT3 ATG12_BHLHE41 ATG12_FAS_ID2 ATG12_ATG3_ID2_TCF3 ATG12_NAMPT ID2_NAMPT_RPS19BP1 ATG3_DIABLO_ID2_NAMPT ATG12_ATG7 ID2_MMP9_TCF3 ATG12_ID2_TCF3_STAT3 ID2_BECN1 DIABLO_NAMPT_SATB1 DIABLO_FAS_NAMPT_STAT3 E2F1_FAS ATG12_CSE1L_MMP9 ATG12_CSE1L_DIABLO_MMP9 ATG12_ATG5 ATG12_MMP9_RPS19BP1 ATG12_ID2_TCF3_SATB1 ID2_STAT3 ID2_MMP9_BECN1 DIABLO_FAS_MMP9_STAT3 ATG12_ULK1 DIABLO_NAMPT_STAT3 ATG12_ID2_MMP9_BHLHE41 DIABLO_BECN1 ATG12_DIABLO_MMP9 ATG12_BNIP3_ID2_MMP9 ATG12_LAMP1 ATG12_FAS_RPS19BP1 DIABLO_FAS_SATB1_STAT3 ATG12_LC3 DIABLO_FAS_MMP9 DIABLO_FAS_NAMPT_RPS19BP1 DIABLO_TCF3 ID2_MMP9_NAMPT ATG12_ATG3_ID2_MMP9 AKT1_ATG12 ATG12_ID2_STAT3 ATG12_ID2_MMP9_NAMPT ATG12_FRAP1 ATG12_DIABLO_TCF3 DIABLO_FAS_NAMPT_SESN2 DIABLO_ID2 ATG12_ATG3_ID2 DIABLO_ID2_NAMPT_SESN2 ID2_TCF3 ATG12_DIABLO_ID2 ATG12_ID2_TCF3_RPS19BP1 DIABLO_SATB1 CSE1L_DIABLO_STAT3 ATG12_DIABLO_MMP9_TCF3 ATG12_BECN1 DIABLO_ID2_STAT3 ATG12_CSE1L_ID2_SATB1 ATG12_SIRT1 ATG12_ATG3_RPS19BP1 ATG12_FAS_MMP9_RPS19BP1 NAMPT_STAT3 ATG12_DIABLO_SATB1 ID2_MMP9_TCF3_STAT3 ATG12_BNIP3 ATG12_MMP9_TCF3 ATG12_DIABLO_ID2_NAMPT DIABLO_MMP9 ATG3_DIABLO_NAMPT DIABLO_ID2_TCF3_STAT3 ATG12_UVRAG ATG12_DIABLO_NAMPT ATG12_ULK1_ID2_TCF3 DIABLO_FRAP1 ATG12_CSE1L_RPS19BP1 ATG12_ID2_TCF3_SESN2 NAMPT_RPS19BP1 DIABLO_MMP9_NAMPT BNIP3_CSE1L_DIABLO_MMP9 AKT1_NAMPT ATG12_ATG3_DIABLO ATG12_DIABLO_ID2_TCF3 E2F1_UVRAG DIABLO_SATB1_STAT3 ATG12_ATG5_ID2_MMP9 ATG3_DIABLO ID2_TCF3_STAT3 ATG12_ID2_SATB1_STAT3 NAMPT_UVRAG ATG12_RPS19BP1_SATB1 ATG12_MMP9_TCF3_RPS19BP1 BNIP3_DIABLO ATG12_DIABLO_STAT3 ATG12_DIABLO_FAS_ID2 DIABLO_LC3 ATG12_TCF3_RPS19BP1 ATG12_CSE1L_ID2_SESN2 DIABLO_SIRT1 DIABLO_NAMPT_SESN2 DIABLO_FAS_MMP9_TCF3 LC3_NAMPT ATG12_DIABLO_SESN2 ATG12_ID2_TCF3_BHLHE41 DIABLO_SESN2 ATG12_ULK1_ID2 ATG12_FAS_ID2_STAT3 FAS_STAT3 ATG12_ATG5_ID2 BNIP3_CSE1L_ID2_MMP9 FAS_NAMPT AKT1_DIABLO_NAMPT CSE1L_DIABLO_FAS_NAMPT E2F1_NAMPT ATG12_ID2_BECN1 ATG12_CSE1L_ID2_TCF3 ATG12_SESN3 ATG12_FAS_MMP9 ATG12_ID2_NAMPT_RPS19BP1 BCL2_TKT ATG12_DIABLO_BHLHE41 ATG12_ID2_MMP9_BECN1 ATG7_NAMPT ATG12_RPS19BP1_STAT3 DIABLO_FAS_LC3_NAMPT ATG7_BECN1 DIABLO_NAMPT_RPS19BP1 FAS_ID2_NAMPT_RPS19BP1 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 DIABLO_FAS_ID2_MMP9_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3 ATG12_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_CSE1L_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3 ATG12_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2
ATG12_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_FAS_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ID2_MMP9_TCF3 DIABLO_FAS_ID2_NAMPT_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_SESN2 ATG12_ID2_MMP9_TCF3_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3 ATG12_BNIP3_ID2_MMP9_RPS19BP1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT ATG12_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3 ATG12_CSE1L_ID2_MMP9_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2 DIABLO_FAS_ID2_NAMPT_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1 DIABLO_ID2_MMP9_TCF3_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9 ATG12_ID2_MMP9_TCF3_BHLHE41 ATG12_ATG3_BNIP3_ID2_MMP9_SATB1 ATG12_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SATB1 CSE1L_DIABLO_ID2_MMP9_NAMPT ATG12_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_DIABLO_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1 DIABLO_ID2_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_NAMPT_SATB1_STAT3 ATG12_ATG3_CSE1L_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_DIABLO_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SESN2 DIABLO_FAS_ID2_MMP9_STAT3 ATG12_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_CSE1L_ID2_MMP9_BHLHE41 ATG12_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_ID2_MMP9_NAMPT_STAT3 ATG12_ATG3_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_NAMPT_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9 ATG12_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_TCF3_NAMPT ATG12_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_SATB1 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_ID2_MMP9_BHLHE41 ATG12_DIABLO_FAS_ID2_MMP9_TCF3 ATG3_DIABLO_FAS_ID2_NAMPT ATG12_ULK1_ID2_MMP9_TCF3_SESN2 CSE1L_DIABLO_FAS_ID2_NAMPT ATG3_DIABLO_FAS_ID2_MMP9_NAMPT ATG12_CSE1L_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_ID2_MMP9_SESN2 ATG12_CSE1L_ULK1_ID2_MMP9 ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41 DIABLO_FAS_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9 CSE1L_DIABLO_ID2_NAMPT_STAT3 DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1 DIABLO_ID2_MMP9_TCF3_STAT3 ATG12_ATG5_ID2_MMP9_TCF3_SATB1 DIABLO_ID2_TCF3_NAMPT_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3 CSE1L_DIABLO_FAS_MMP9_NAMPT ATG12_ATG3_CSE1L_ID2_MMP9_SATB1 DIABLO_FAS_ID2_NAMPT_RPS19BP1 ATG12_ATG3_ID2_MMP9_TCF3_STAT3 BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_SATB1 DIABLO_ID2_MMP9_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_DIABLO_FAS_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG5_FAS_ID2_MMP9 DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_LC3_ID2_MMP9_TCF3 ATG12_ATG3_CSE1L_ID2_MMP9_SESN2 ATG12_FAS_ID2_MMP9_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1 FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_ATG5_BNIP3_FAS_ID2_MMP9 ATG12_ID2_MMP9_TCF3_BECN1 ATG12_ATG5_ULK1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3 E2F1_FAS_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1
ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ID_MMP9_TCF3 ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3 ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1 ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2 ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1 ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2 ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG
。
13.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测B组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表12]
一种 两种的组合 三种的组合 四种的组合 DIABLO ATG3_BECN1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1 BECN1 ATG3_HMGB1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG
HMGB1 BCL2L1_TKT ATG3_HMGB1_UVRAG ATG3_BCL2_TKT_HMGB1 CSE1L_DIABLO ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_RAGE BCL2_HMGB1 ATG3_HMGB1_SIRT1 ATG3_BCL2_HMGB1_HMGB2 ATG12_ATG3 ATG3_BECN1_SATB1 ATG3_CDH1_HMGB1_SIRT1 ATG3_NAMPT ATG3_HMGB1_LAMP2 ATG3_BCL2_HMGB1_MMP2 HMGB1_TWIST1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_HMGB2_RAGE TKT_HMGB1 ATG3_LC3_BECN1 ATG3_BCL2_BNIP3_HMGB1 LAMP1_HMGB1 ATG3_HMGB1_KIAA1967 ATG3_CDH1_CASP3_HMGB1 TKT_BECN1 BCL2L1_TKT_CASP3 ATG3_CDH1_HMGB1_KIAA1967 HMGB1_TP63 ATG12_ATG3_HMGB1 ATG3_HMGB1_RAGE_UVRAG BCL2_TKT BCL2L1_TKT_SIRT1 ATG3_HMGB1_RAGE_SIRT1 TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_TKT_HMGB1_UVRAG FASLG_HMGB1 BCL2_TKT_HMGB1 ATG3_BCL2_LAMP1_HMGB1 TKT_NAMPT ATG3_BECN1_SESN3 ATG3_BCL2_HMGB1_RAPTOR ATG5_HMGB1 ATG3_BNIP3_HMGB1 AIFM1_ATG3_BCL2_HMGB1 HMGB1_SIRT1 ATG3_BECN1_HMGB1 ATG3_CASP3_HMGB1_RAGE ATG12_HMGB1 AIFM1_ATG3_HMGB1 ATG12_ATG3_HMGB1_RAGE HMGB1_RAGE ATG3_LAMP1_HMGB1 ATG3_TKT_CASP3_HMGB1 DIABLO_NAMPT BCL2L1_TKT_FASLG ATG3_TKT_HMGB1_KIAA1967 HMGB1_UVRAG BCL2_BCL2L1_TKT ATG3_BCL2L1_TKT_BECN1 DIABLO_BECN1 TKT_HMGB1_TWIST1 ATG12_ATG3_CDH1_HMGB1 BECN1_SATB1 ATG3_NNMT_HMGB1 ATG3_CDH1_HMGB1_RAGE BCL2L1_SIRT1 BCL2L1_TKT_HMGB1 ATG3_BCL2_FRAP1_HMGB1 BCL2L1_HMGB1 ATG3_BCL2L1_BECN1 ATG3_BCL2_HMGB1_LAMP2 TKT_SIRT1 ATG5_TKT_HMGB1 ATG3_BCL2_DIABLO_HMGB1 DIABLO_TCF3 ATG3_FASLG_HMGB1 ATG3_TKT_HMGB1_SIRT1 HMGB1_LAMP2 ATG3_MMP9_BECN1 ATG3_BCL2_CBS_HMGB1 DIABLO_SATB1 ATG3_LAMP1_BECN1 ATG3_BCL2_CASP8_HMGB1 HMGB1_RAPTOR ATG3_E2F1_HMGB1 ATG3_BCL2_PTEN_HMGB1 E2F1_HMGB1 HMGB1_RAPTOR_TWIST1 ATG3_HMGB1_RAGE_RAPTOR ATG5_BECN1 AKT1_ATG3_BECN1 ATG3_TKT_HMGB1_RAGE ATG12_SATB1 ATG3_ULK1_HMGB1 ATG3_BCL2_CASP3_HMGB1 BCL2L1_BECN1 TKT_HMGB1_SIRT1 ATG3_BCL2_HMGB1_SATB1 CASP3_HMGB1 ATG3_BAX_HMGB1 ATG3_HMGB1_LAMP2_RAGE ATG12_CSE1L ATG3_PTEN_HMGB1 ATG3_CDH1_HMGB1_LAMP2 ATG7_HMGB1 ATG3_TKT_HMGB1 ATG3_HMGB1_HMGB2_UVRAG ATG3_SIRT1 ATG3_TKT_BECN1 ATG3_BCL2L1_TKT_HMGB1 CASP8_HMGB1 ATG3_HMGB1_TWIST1 CDH1_HMGB1_TP63_UVRAG ATG3_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2L1_TKT_CASP3 TKT_KIAA1967 TKT_HMGB1_UVRAG ATG3_HMGB1_KIAA1967_RAGE ATG12_BCL2L1 BCL2L1_TKT_CDH2 ATG3_BCL2_DRAM_HMGB1 DRAM_HMGB1 BCL2L1_TKT_KIAA1967 ATG3_BCL2_HMGB1_UVRAG LC3_FASLG ATG3_BCL2L1_HMGB1 BCL2_BCL2L1_TKT_CASP3 HMGB1_KIAA1967 ATG3_ATG5_HMGB1 ATG3_TKT_BECN1_HMGB1 TKT_SESN1 ATG3_DRAM_HMGB1 ATG3_TKT_HMGB1_LAMP2 ATG3_DIABLO ATG3_HMGB1_SATB1 ATG3_BCL2_PRKAA1_HMGB1 DIABLO_SIRT1 ATG3_BCL2L1_TKT BCL2L1_TKT_CASP3_SIRT1 BECN1_HMGB1 ATG3_PRKAA1_HMGB1 BCL2L1_TKT_CASP3_FASLG AIFM1_HMGB1 TKT_CASP3_HMGB1 BCL2L1_TKT_CASP3_CDH2 ID2_BECN1 ATG3_XIAP_HMGB1 ATG3_BCL2_NNMT_HMGB1 CSE1L_BECN1 TKT_HMGB1_KIAA1967 ATG3_CDH1_HMGB1_RAPTOR TKT_ULK1 TKT_HMGB1_LAMP2 ATG3_BNIP3_HMGB1_RAGE BNIP3_HMGB1 HMGB1_RAGE_TWIST1 ATG3_BAX_BCL2_HMGB1 TKT_UVRAG ATG12_BCL2L1_TKT ATG3_BCL2_ID2_HMGB1 ATG5_TKT ATG3_PTEN_BECN1 ATG3_BCL2_HMGB1_STAT3
五种的组合 六种的组合 ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE
ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2 ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967 ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2 ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967 ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1 ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1 ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1 ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3 ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1 ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1 ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1
AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1 ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGEUVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE NNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG
。
14.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测C组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表13]
一种 两种的组合 三种的组合 四种的组合 FASLG CIAP2_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG CIAP2 E2F1_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG CSE1L LC3_FASLG E2F1_LC3_FASLG BNIP3_FAS_LC3_FASLG FAS DIABLO_FASLG FAS_FASLG_RPS19BP1 DRAM_FAS_LC3_FASLG TCF3 FAS_FASLG E2F1_FAS_FASLG E2F1_FAS_LC3_FASLG FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG3_FAS_LC3_FASLG PTEN_FASLG DIABLO_LC3_FASLG ATG7_FAS_LC3_FASLG CASP3_FASLG ATG7_FAS_FASLG FAS_LC3_FASLG_STAT3 FASLG_SESN2 CIAP2_FASLG_SESN3 FAS_FRAP1_LC3_FASLG FASLG_HMGB1 CIAP2_FASLG_UVRAG FAS_LC3_FASLG_SESN3 CDH2_FASLG BNIP3_LC3_FASLG FAS_LC3_FASLG_SIRT1 FRAP1_FASLG LC3_CIAP2_FASLG FAS_LC3_BECN1_FASLG ATG7_FASLG LC3_FASLG_SESN2 ATG5_FAS_LC3_FASLG ATG3_FAS FRAP1_LC3_FASLG FAS_LC3_FASLG_RPS19BP1 FASLG_HMGB2 LC3_FASLG_SESN3 FAS_LAMP1_LC3_FASLG FASLG_UVRAG ATG3_FAS_FASLG FAS_LC3_FASLG_NAMPT DIABLO_FAS ATG7_LC3_FASLG AKT1_FAS_LC3_FASLG FASLG_MMP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_SESN2 TKT_FASLG DIABLO_FASLG_SESN2 FAS_LC3_MMP9_FASLG PTEN_CIAP2 DRAM_LC3_FASLG FAS_FASLG_RPS19BP1_SESN3 FAS_LC3 CIAP2_FASLG_HMGB1 FAS_FASLG_RPS19BP1_UVRAG CBS_FASLG FAS_FASLG_SESN3 FAS_LC3_CDH1_FASLG AIFM1_FASLG LC3_FASLG_UVRAG ATG12_FAS_LC3_FASLG CASP3_CIAP2 CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_SESN3 FASLG_SESN3 FAS_FASLG_SESN2 DIABLO_FAS_FASLG_UVRAG ATG3_FASLG PTEN_CIAP2_FASLG FAS_LC3_FASLG_LAMP2 CASP8_FASLG DIABLO_FASLG_SESN3 FAS_LC3_ID2_FASLG XIAP_FASLG ATG7_CIAP2_FASLG DIABLO_FAS_FASLG_SESN2 AGER_FASLG LC3_FASLG_SIRT1 FAS_LC3_BHLHE41_FASLG ATG3_ULK1 LC3_FASLG_RPS19BP1 DIABLO_DRAM_FAS_FASLG BNIP3_FASLG FASLG_SESN2_SESN3 DIABLO_FAS_FASLG_STAT3 FAS_UVRAG DRAM_FAS_FASLG DRAM_FAS_FASLG_RPS19BP1 CIAP2_RAGE ID2_CIAP2_FASLG DIABLO_FAS_FRAP1_FASLG ATG3_TCF3 FAS_FASLG_STAT3 FAS_FASLG_SESN2_UVRAG FASLG_RAGE AKT1_CIAP2_FASLG ATG3_FAS_FASLG_SESN2 E2F1_CIAP2 DIABLO_FRAP1_FASLG ATG7_DIABLO_FAS_FASLG FASLG_VEGF BNIP3_FAS_FASLG FAS_LC3_TCF3_FASLG E2F1_FAS FAS_LAMP1_FASLG ATG7_FAS_FASLG_UVRAG XIAP_CIAP2 TKT_CIAP2_FASLG DIABLO_FAS_FASLG_NAMPT BCL2L1_FASLG ATG7_DIABLO_FASLG DIABLO_FAS_FASLG_SIRT1 BNIP3_FAS FRAP1_FASLG_SESN2 DIABLO_FAS_LAMP1_FASLG FASLG_SESN1 E2F1_ULK1_FASLG FAS_FRAP1_FASLG_RPS19BP1 FASLG_KIAA1967 DRAM_CIAP2_FASLG CSE1L_FAS_LC3_FASLG AIFM1_CIAP2 PTEN_CASP3_FASLG DIABLO_FAS_BECN1_FASLG DRAM_FASLG LC3_FASLG_NAMPT E2F1_LC3_ID2_FASLG ATG3_CIAP2 PTEN_CDH1_CIAP2 AKT1_DIABLO_FAS_FASLG CSE1L_FASLG ATG12_CIAP2_FASLG ATG3_DIABLO_FAS_FASLG FASLG_RAPTOR FASLG_RPS19BP1_SESN3 E2F1_FAS_FASLG_SESN3 TCF3_FASLG MMP9_CIAP2_FASLG ATG7_FAS_FASLG_SESN2 FASLG_STAT3 LAMP1_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1 ULK1_FASLG LC3_BECN1_FASLG DRAM_FAS_FASLG_UVRAG PRKAA1_CIAP2 CDH1_CIAP2_FASLG LC3_MMP9_FASLG_SESN2 FASLG_SIRT1 BECN1_CIAP2_FASLG FAS_FASLG_SESN3_UVRAG ATG12_FASLG CIAP2_FASLG_HMGB2 DIABLO_FAS_FASLG_LAMP2 LAMP1_FASLG E2F1_FASLG_LAMP2 DIABLO_FAS_ID2_FASLG NNMT_FASLG CIAP2_FASLG_SIRT1 E2F1_LC3_FASLG_LAMP2 BCL2L1_CIAP2 PTEN_XIAP_FASLG E2F1_LC3_MMP9_FASLG CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合
BNIP3_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2 DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN3 DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SIRT1 DIABLO_FAS_LC3_BECN1_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DIABLO_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_BECN1_FASLG ATG7_DRAM_FAS_LC3_FASLG DRAM_FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_SIRT1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BECN1_FASLG DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN3 DIABLO_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN3 DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2 ATG5_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG ATG5_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_FASLG_SESN3_SIRT1 FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BHLHE41_FASLG_UVRAG DRAM_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2 DIABLO_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_DRAM_FAS_LC3_FASLG FAS_LC3_BECN1_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG ATG3_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN3_SIRT1 BNIP3_FAS_LC3_FASLG_SIRT1 ATG3_DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_FRAP1_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN3_STAT3 DIABLO_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_BECN1_FASLG_SESN2 DIABLO_FAS_LC3_FASLG_NAMPT BNIP3_FAS_LC3_FASLG_SESN2_SIRT1 FAS_LC3_MMP9_FASLG_RPS19BP1 DIABLO_DRAM_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_BECN1_FASLG BNIP3_FAS_LC3_BECN1_FASLG_SESN3 E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG ATG3_FAS_FRAP1_LC3_MMP9_FASLG DIABLO_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_BECN1_FASLG_SESN3 FAS_LC3_ID2_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BECN1_FASLG DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_DRAM_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG DRAM_FAS_LAMP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG ATG3_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG FAS_LC3_FASLG_STAT3_UVRAG ATG5_DRAM_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_STAT3 FAS_LC3_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_FASLG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG AKT1_DRAM_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_SESN2 FAS_LC3_FASLG_SESN2_UVRAG ATG5_FAS_LC3_MMP9_FASLG_UVRAG FAS_LC3_BHLHE41_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_FASLG_NAMPT DIABLO_DRAM_FAS_LC3_FASLG_STAT3 FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG_SESN3 ATG7_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_TCF3_FASLG_UVRAG AKT1_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1 E2F1_FAS_LC3_ID2_FASLG ATG5_DRAM_FAS_LC3_FASLG_STAT3 DRAM_FAS_LC3_CDH1_FASLG ATG7_DRAM_FAS_LC3_MMP9_FASLG PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合 八种的组合 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3 ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3 ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1 BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2 ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN3 BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG BNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1 FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG
。
15.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测C组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表14]
一种 两种的组合 二种的组合 四种的组合 CSE1L ID2_CIAP2 ID2_CIAP2_SESN2 AIFM1_ID2_CIAP2_SESN2 CIAP2 CASP3_CIAP2 ID2_CASP3_CIAP2 PTEN_ID2_CIAP2_SESN2 TCF3 ID2_TCF3 ULK1_ID2_HMGB2 DIABLO_ID2_CASP3_CIAP2 CDH2 DIABLO_CDH2 ULK1_ID2_HMGB1 DRAM_FRAP1_CIAP2_TP63 FASLG CSE1L_CDH2 DIABLO_ID2_CASP3 BAX_ID2_CIAP2_SESN2 BECN1 CSE1L_TCF3 ULK1_ID2_AGER ID2_CIAP2_SESN2_VEGF CASP3 CSE1L_CASP3 ID2_CIAP2_RPS19BP1 DRAM_ID2_CIAP2_SESN2 CDH1 CSE1L_RPS19BP1 CASP8_ULK1_ID2 ID2_CIAP2_RPS19BP1_SESN2 CDH2_CIAP2 ID2_TCF3_CIAP2 CBS_ID2_CIAP2_SESN2 ULK1_ID2 FRAP1_ID2_CIAP2 ATG3_ID2_CIAP2_SESN2 CSE1L_ID2 AIFM1_CDH1_CIAP2 NNMT_ID2_CIAP2_SESN2 CDH1_CIAP2 PTEN_CDH1_CIAP2 DIABLO_ID2_CIAP2_SESN2 CSE1L_FASLG ULK1_ID2_CIAP2 PRKAA1_ID2_CIAP2_SESN2 NNMT_CIAP2 DIABLO_ID2_CDH2 FRAP1_ID2_CIAP2_SESN2 CSE1L_MMP9 CDH1_CIAP2_VEGF DIABLO_DRAM_ID2_CASP3 CSE1L_CDH1 CDH1_CCNG2_CIAP2 XIAP_ID2_CIAP2_SESN2 CIAP2_RPS19BP1 BAX_CDH1_CIAP2 ID2_CIAP2_RAGE_SESN2 ID2_CDH2 ATG3_ID2_TCF3 DRAM_CIAP2_SESN2_TP63 CDH2_RPS19BP1 ULK1_ID2_MMP2 BNIP3_ID2_CIAP2_SESN2 CSE1L_STAT3 CBS_ULK1_ID2 BCL2L1_ID2_CIAP2_SESN2 DIABLO_CASP3 DIABLO_ID2_CIAP2 AIFM1_DIABLO_CDH1_CIAP2 CDH1_TCF3 LC3_ID2_CIAP2 ID2_CCNG2_CIAP2_SESN2 CSE1L_SIRT1 PTEN_ULK1_ID2 LC3_ID2_CIAP2_SESN2 CIAP2_SESN2 BAX_ULK1_ID2 ID2_CASP3_CIAP2_RPS19BP1 AIFM1_CIAP2 DIABLO_PTEN_CDH1 AIFM1_CDH1_CIAP2_SESN2 DIABLO_KIAA1967 CDH1_CASP3_CIAP2 ATG3_ID2_TCF3_RPS19BP1 CSE1L_KIAA1967 ULK1_ID2_CDH2 DIABLO_FRAP1_ID2_CDH2 AKT1_CSE1L CDH1_CIAP2_RAGE E2F1_ID2_CIAP2_SESN2 CSE1L_SESN2 ID2_CDH2_CIAP2 ID2_CASP3_CIAP2_SESN2 FRAP1_CDH2 NNMT_ID2_CIAP2 DRAM_ID2_CIAP2_RPS19BP1 FRAP1_CIAP2 XIAP_CIAP2_SESN2 ID2_CIAP2_HMGB1_SESN2 TCF3_FASLG CSE1L_ID2_CASP3 PTEN_ID2_CASP3_CIAP2 FASLG_SESN2 CSE1L_FRAP1_CDH2 ATG3_ID2_MMP9_TCF3 CSE1L_DIABLO BCL2_ID2_SESN2 LAMP1_ID2_CIAP2_SESN2 CSE1L_SATB1 AIFM1_ULK1_ID2 AIFM1_ID2_CASP3_CIAP2 MMP9_TCF3 ULK1_ID2_RAGE ATG5_ID2_CIAP2_SESN2 ATG12_CSE1L DIABLO_CDH1_CCNG2 DIABLO_PTEN_CDH1_CIAP2 ATG7_CSE1L BAX_DIABLO_CDH1 LAMP1_ID2_CASP3_CIAP2 CSE1L_BECN1 CSE1L_ID2_CDH2 ID2_CIAP2_HMGB2_SESN2 XIAP_CIAP2 AIFM1_CIAP2_SESN2 BCL2L1_CSE1L_ID2_SESN2 CSE1L_FAS NNMT_CDH1_CIAP2 TKT_ID2_CIAP2_SESN2 TCF3_RPS19BP1 CBS_ID2_CIAP2 DIABLO_XIAP_ID2_SESN2 XIAP_SESN2 DIABLO_CDH1_VEGF FRAP1_LC3_ID2_CIAP2 CIAP2_KIAA1967 ID2_MMP9_TCF3 ATG7_ID2_CIAP2_SESN2 TKT_CIAP2 AIFM1_DIABLO_CDH1 ID2_AGER_CIAP2_SESN2 PRKAA1_CIAP2 PRKAA1_CIAP2_SESN2 CSE1L_ID2_CASP3_CIAP2 CDH2_FASLG CDH1_ID2_CIAP2 DRAM_CASP3_CIAP2_TP63 CSE1L_FRAP1 CSE1L_CASP3_CIAP2 PTEN_CDH1_ID2_CIAP2 CSE1L_CIAP2 ULK1_ID2_VEGF CDH1_ID2_CIAP2_RPS19BP1 CSE1L_ULK1 ID2_CIAP2_HMGB1 ATG3_ULK1_ID2_HMGB1 PTEN_CIAP2 BCL2L1_CDH1_CIAP2 FRAP1_ID2_CIAP2_RPS19BP1 BCL2L1_CIAP2 ID2_CIAP2_MMP2 DIABLO_PTEN_ID2_CASP3 CIAP2_VEGF CSE1L_ID2_CIAP2 ID2_CIAP2_SESN2_TP63 ATG3_TCF3 BCL2L1_CSE1L_CDH1 ID2_TCF3_CIAP2_SESN2 AKT1_TCF3 CSE1L_CDH1_CASP3 DIABLO_CDH1_CIAP2_VEGF CSE1L_LC3 CSE1L_XIAP_SESN2 ATG3_ULK1_ID2_AGER
TKT_CDH2 PRKAA1_CDH1_CIAP2 ID2_CIAP2_MMP2_SESN2 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63 DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_DRAM_FRAP1_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_FRAP1_XIAP_CIAP2_TP63 DRAM_TKT_ID2_CIAP2_SESN2_TP63 DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_CDH1_CIAP2_TP63 AIFM1_DRAM_FRAP1_CIAP2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_PTEN_ID2_CIAP2_SESN2_TP63 PTEN_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 BAX_CDH1_ID2_CIAP2_SESN2 DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63 DRAM_FRAP1_ID2_CIAP2_TP63 ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63 DRAM_TKT_CASP3_CIAP2_TP63 ATG7_DRAM_ID2_CIAP2_SESN2_TP63 CDH1_ID2_CCNG2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_PTEN_ID2_CIAP2_SESN2 ATG5_DRAM_ID2_CIAP2_SESN2_TP63 DIABLO_FRAP1_CDH1_ID2_CIAP2 AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2 AIFM1_CBS_ID2_CIAP2_SESN2 AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63 AIFM1_LAMP1_ID2_CIAP2_SESN2 BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_ID2_CASP3_CIAP2_TP63 DRAM_NNMT_ID2_CIAP2_SESN2_TP63 DIABLO_PTEN_CDH1_ID2_CIAP2 CASP8_DRAM_ID2_CIAP2_SESN2_TP63 CDH1_ID2_CIAP2_SESN2_VEGF DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63 DIABLO_CDH1_ID2_CASP3_CIAP2 DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63 AIFM1_ATG3_ID2_CIAP2_SESN2 DRAM_LAMP1_ID2_CIAP2_SESN2_TP63 AIFM1_BNIP3_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 AIFM1_DIABLO_CDH1_ID2_CIAP2 BNIP3_DRAM_ID2_CIAP2_SESN2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2 DRAM_ID2_MMP9_CIAP2_SESN2_TP63 AIFM1_BAX_ID2_CIAP2_SESN2 AKT1_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_E2F1_CASP3_CIAP2_TP63 DRAM_ID2_CIAP2_RAGE_SESN2_TP63 AIFM1_ID2_CIAP2_HMGB2_SESN2 ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63 AIFM1_ID2_MMP9_CIAP2_SESN2 DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63 DIABLO_CDH1_ID2_CIAP2_VEGF DRAM_XIAP_ID2_CIAP2_SESN2_TP63 DIABLO_DRAM_XIAP_ID2_SESN2 AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63 AIFM1_ATG5_ID2_CIAP2_SESN2 ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63 AIFM1_ID2_CIAP2_HMGB1_SESN2 CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63 BAX_DIABLO_CDH1_ID2_CIAP2 AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63 DRAM_FRAP1_NNMT_CIAP2_TP63 AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63 FRAP1_CDH1_ID2_CIAP2_RPS19BP1 BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_XIAP_CIAP2_SESN2_TP63 CBS_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2 AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63 AIFM1_ID2_CIAP2_SESN2_VEGF DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63 AIFM1_TKT_ID2_CIAP2_SESN2 DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2 ATG3_ID2_MMP9_TCF3_RPS19BP1 DRAM_ID2_CIAP2_SESN2_TP63_VEGF ATG5_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63 CBS_FRAP1_ID2_CIAP2_SESN2 BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_DIABLO_ID2_CASP3_CIAP2 AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63 AIFM1_NNMT_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63 ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63 ATG3_FRAP1_ID2_CIAP2_SESN2 AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63 BAX_DIABLO_DRAM_ID2_CASP3 AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63 LAMP1_PTEN_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63 CDH1_ID2_CIAP2_RAGE_SESN2 AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63 CBS_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_CIAP2_TP63_VEGF DIABLO_CDH1_ID2_CCNG2_CIAP2 AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63 DIABLO_LAMP1_ID2_CASP3_CIAP2 DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2 AIFM1_DRAM_CASP3_CIAP2_TP63 DRAM_TKT_XIAP_CIAP2_SESN2_TP63 BCL2L1_DRAM_FRAP1_CIAP2_TP63 AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63
CDH1_ID2_MMP9_TCF3_CIAP2 BAX_CDH1_ID2_MMP9_TCF3_CIAP2
七种的组合 八种的组合 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63 AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63 AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63 AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGF AIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGF DRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_T T_CIAP2_SATB1_TP63 ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63 A  M1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF ATG12_DR M_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63 AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF DRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 AIFM1_ TG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 BC     DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_DRAM_NNMT_PTEN_ID2_CIAP2_SESN2_TP63 AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63 ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63 AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63 BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63 CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER
16.如权利要求1所述的组合物或试剂盒，所述组合物或试剂盒用于预测C组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表15]
一种 两种的组合 三种的组合 四种的组合 FASLG FAS_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG CIAP2 LC3_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG FAS E2F1_FASLG E2F1_LC3_FASLG E2F1_FAS_LC3_FASLG CSE1L CIAP2_FASLG FAS_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG TCF3 DIABLO_FASLG E2F1_FAS_FASLG DRAM_FAS_LC3_FASLG FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG7_FAS_LC3_FASLG FASLG_SESN2 DIABLO_LC3_FASLG FAS_LAMP1_LC3_FASLG CASP3_FASLG ATG7_FAS_FASLG FAS_FRAP1_LC3_FASLG FASLG_UVRAG FAS_FASLG_SESN2 ATG3_FAS_LC3_FASLG FRAP1_FASLG LC3_FASLG_SESN2 FAS_LC3_FASLG_RPS19BP1 PTEN_FASLG FAS_LAMP1_FASLG FAS_LC3_FASLG_SESN3 FASLG_HMGB1 ATG3_FAS_FASLG FAS_LC3_FASLG_SESN2 ATG3_FAS C IAP2_FASLG_SESN3 ATG5_FAS_LC3_FASLG CASP3_CIAP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_STAT3 TCF3_FASLG FRAP1_LC3_FASLG FAS_LC3_FASLG_SIRT1 ATG7_FASLG BNIP3_LC3_FASLG AKT1_FAS_LC3_FASLG PTEN_CIAP2 FAS_FASLG_SESN3 FAS_LC3_ID2_FASLG CDH2_FASLG BNIP3_FAS_FASLG FAS_LC3_FASLG_NAMPT FASLG_SESN3 DIABLO_FASLG_SESN2 FAS_LC3_BECN1_FASLG DIABLO_FAS CIAP2_FASLG_UVRAG FAS_LC3_MMP9_FASLG FAS_LC3 LC3_FASLG_UVRAG DIABLO_FAS_FASLG_UVRAG ULK1_FASLG LC3_CIAP2_FASLG ATG12_FAS_LC3_FASLG CSE1L_FASLG DRAM_FAS_FASLG FAS_FASLG_RPS19BP1_UVRAG CBS_FASLG LC3_FASLG_SESN3 DIABLO_FAS_FASLG_SESN2 FASLG_HMGB2 FAS_FASLG_STAT3 FAS_LC3_FASLG_LAMP2 FAS_UVRAG ATG7_LC3_FASLG FAS_LC3_CDH1_FASLG LAMP1_FASLG ATG5_FAS_FASLG DIABLO_FAS_FASLG_SESN3 BNIP3_FASLG E2F1_FASLG_SESN2 FAS_LC3_TCF3_FASLG MMP9_FASLG LC3_ID2_FASLG E2F1_LC3_ID2_FASLG TKT_FASLG DRAM_LC3_FASLG FAS_LC3_BHLHE41_FASLG FASLG_STAT3 FAS_TCF3_FASLG DIABLO_FAS_LAMP1_FASLG AKT1_FASLG AKT1_FAS_FASLG DIABLO_DRAM_FAS_FASLG FASLG_MMP2 E2F1_ULK1_FASLG FAS_FASLG_SESN2_UVRAG DRAM_FASLG E2F1_TCF3_FASLG FAS_FASLG_RPS19BP1_SESN3 FASLG_SIRT1 LC3_FASLG_RPS19BP1 DIABLO_FAS_FRAP1_FASLG ATG12_FASLG LC3_MMP9_FASLG DIABLO_FAS_FASLG_STAT3 CIAP2_RAGE FAS_FASLG_SIRT1 ATG7_DIABLO_FAS_FASLG FAS_LAMP1 FAS_ULK1_FASLG CSE1L_FAS_LC3_FASLG ATG5_FASLG FAS_FASLG_NAMPT E2F1_LC3_MMP9_FASLG ATG3_FASLG LC3_FASLG_SIRT1 DRAM_FAS_FASLG_RPS19BP1 E2F1_FAS CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1 BECN1_FASLG ATG12_FAS_FASLG FAS_LC3_ULK1_FASLG E2F1_CIAP2 FAS_BECN1_FASLG DIABLO_FAS_FASLG_SIRT1 CASP8_FASLG ATG5_LC3_FASLG DIABLO_FAS_ID2_FASLG XIAP_CIAP2 LC3_BECN1_FASLG AKT1_DIABLO_FAS_FASLG CDH1_FASLG LC3_FASLG_STAT3 DIABLO_FAS_FASLG_NAMPT FASLG_NAMPT E2F1_FASLG_SESN3 ATG3_FAS_FASLG_SESN2 BNIP3_FAS AKT1_LC3_FASLG FAS_FASLG_RPS19BP1_SESN2 FASLG_LAMP2 FAS_FASLG_LAMP2 DIABLO_FAS_BECN1_FASLG AGER_FASLG LC3_TCF3_FASLG DIABLO_FAS_CDH1_FASLG ID2_FASLG LC3_FASLG_NAMPT ATG7_FAS_FASLG_UVRAG AIFM1_FASLG LC3_CDH1_FASLG DIABLO_FAS_FASLG_LAMP2
FASLG_SESN1 ATG12_LC3_FASLG FAS_FRAP1_FASLG_RPS19BP1 AIFM1_CIAP2 PTEN_CDH1_CIAP2 FAS_LAMP1_FASLG_UVRAG PRKAA1_CIAP2 LC3_FASLG_LAMP2 E2F1_FAS_LAMP1_FASLG BCL2L1_CIAP2 DIABLO_FASLG_SESN3 ATG7_FAS_FASLG_RPS19BP1 XIAP_FASLG FAS_CDH1_FASLG E2F1_FAS_FASLG_UVRAG CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 DIABLO_FAS_LC3_ID2_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2 DRAM_FAS_LC3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DIABLO_FAS_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_UVRAG FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_STAT3 DIABLO_FAS_LC3_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_SESN3 DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG DIABLO_FAS_LC3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN3 DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_ID2_FASLG_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG5_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2 DIABLO_FAS_LC3_BECN1_FASLG BNIP3_DIABLO_FAS_LC3_ID2_FASLG DIABLO_FAS_LC3_CDH1_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_FASLG_SESN2 DIABLO_FAS_LC3_ID2_FASLG_SIRT1 D RAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_FAS_LC3_FASLG_SESN2_SESN3 E2F1_FAS_LC3_ID2_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG D IABLO_FAS_LC3_FASLG_NAMPT DIABLO_FAS_LC3_ID2_BECN1_FASLG DIABLO_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_ID2_FASLG_SESN2_UVRAG FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LC3_CDH1_ID2_FASLG FAS_LAMP1_LC3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 AKT1_DIABLO_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_SESN3 DIABLO_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_NAMPT DIABLO_FAS_LC3_BHLHE41_FASLG DIABLO_FAS_LC3_ID2_FASLG_SESN2 FAS_LC3_FASLG_STAT3_UVRAG DIABLO_FAS_LC3_ID2_FASLG_LAMP2 DIABLO_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_SESN2_SIRT1 E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_STAT3 BNIP3_FAS_FRAP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LAMP1_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_STAT3 FAS_LC3_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG AKT1_FAS_LC3_FASLG_UVRAG ATG5_FAS_LC3_ID2_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN3_UVRAG FAS_FRAP1_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG BNIP3_FAS_LC3_FASLG_STAT3 DIABLO_DRAM_FAS_LC3_CDH1_FASLG FAS_LC3_CDH1_FASLG_UVRAG AKT1_DIABLO_FAS_LC3_ID2_FASLG FAS_LC3_FASLG_LAMP2_UVRAG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_CDH1_FASLG_UVRAG ATG7_FAS_LC3_FASLG_UVRAG DIABLO_FAS_FRAP1_LC3_ID2_FASLG ATG7_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_FASLG_SIRT1 DIABLO_DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LAMP1_LC3_FASLG BNIP3_DIABLO_DRAM_FAS_LC3_FASLG ATG7_BNIP3_FAS_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LAMP1_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG DIABLO_DRAM_FAS_LC3_BECN1_FASLG ATG5_DIABLO_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG DIABLO_FAS_LAMP1_LC3_ID2_FASLG ATG12_DIABLO_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG
E2F1_FAS_LC3_FASLG_SESN3 ATG5_FAS_LC3_FASLG_SESN2_UVRAG AKT1_BNIP3_FAS_LC3_FASLG FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 FAS_LC3_FASLG_NAMPT_UVRAG FAS_LAMP1_LC3_ID2_FASLG_UVRAG ATG12_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合 八种的组合 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3 DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG ATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAG DIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2 DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3 DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAG AKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAG ATG3_D RAM_FAS_LC3_FASLG_SESN2_SESN3 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2
BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2 DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG
。
17.如权利要求1所述的组合物或试剂盒，其中，所述核酸是引物或探针。
18.如权利要求1所述的组合物或试剂盒，其中，所述肝癌预后是对癌症肝脏切除术后的预后的预测。
19.一种用于预测肝癌预后的组合物或试剂盒，所述组合物或试剂盒包含：对选自下表所示的组的一种或至少两种基因中的每一种分别具有特异性的核酸，或对所述基因编码的蛋白有特异性的抗体：
[表2]
Figure FDA00003403731400411
Figure FDA00003403731400421
20.如权利要求19所述的组合物或试剂盒，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
21.如权利要求19所述的组合物或试剂盒，其中，所述核酸是引物或探针。
22.如权利要求19所述的组合物或试剂盒，其中，所述预测肝癌预后是预测癌症肝脏切除术后的预后。
23.一种根据分期来预测肝癌预后的方法，所述方法包括：
(A)检测获自肝癌患者的样品中的选自由下表所示的基因组成的组的一种或至少两种基因的表达水平或表达模式中的一项或多项；和
(B)将步骤(A)的结果与对照组的测量结果进行比较，从而预测肝癌预后，
其中，所述肝癌患者属于选自A1组、A2组、B组或C组的一个或多个组；其中A1组为门静脉侵袭阴性患者组，患者处于BCLC(巴塞罗那临床肝癌)分期系统的0期或A期，具有1个尺寸为5cm以下的肿瘤或3个以下尺寸为3cm以下的肿瘤；A2组为门静脉侵袭阴性患者组，患者具有尺寸大于5cm的肿瘤；B组为门静脉侵袭阴性患者组，患者处于BCLC分期系统中期，具有多个尺寸大于3cm的肿瘤或数量大于3的多个肿瘤；C组为门静脉侵袭阳性患者组，不论肿瘤尺寸和数量如何；
[表1]
Figure FDA00003403731400431
24.如权利要求23所述的方法，其中，由基因组成的所述组是下表所示的基因组成的组：
[表2]
Figure FDA00003403731400442
25.如权利要求23所述的方法，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
Figure FDA00003403731400452
Figure FDA00003403731400461
26.如权利要求23所述的方法，所述方法用于预测A1组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表4]
一种 两种的组合 三种的组合 四种的组合 BCL2L1 FRAP1_SESN1 FRAP1_CASP3_CDH2 ID2_NAMPT_RPS19BP1_SESN3 BECN1 FRAP1_TWIST1 ID2_CDH2_SESN3 FRAP1_LC3_CASP3_CDH2 BAX FRAP1_CASP3 FRAP1_CDH2_SESN1 FRAP1_TKT_CASP3_CDH2 CDH2 FRAP1_CCNG2 FRAP1_LC3_CASP3 BAX_FRAP1_LC3_CDH2 NAMPT BAX_FRAP1 FRAP1_LC3_TWIST1 ID2_CDH2_NAMPT_SESN3 TWIST1 FRAP1_NNMT BAX_FRAP1_LC3 CBS_ID2_CDH2_SESN3 RPS19BP1 BCL2L1_FRAP1 FRAP1_CDH2_TWIST1 FRAP1_LC3_CDH2_KIAA1967 MMP2 AIFM1_FRAP1 FRAP1_NNMT_CDH2 FRAP1_CDH2_SESN1_STAT3 SESN3 FRAP1_RAGE FRAP1_LC3_NNMT FRAP1_LC3_NNMT_CDH2 ID2 FRAP1_VEGF BAX_FRAP1_CDH2 FRAP1_LC3_CDH2_RAPTOR AGER ID2_CDH2 FRAP1_SESN1_STAT3 ID2_CDH2_RPS19BP1_SESN3 ATG12 FRAP1_PTEN AIFM1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1 NAMPT_SESN3 FRAP1_LC3_VEGF FRAP1_LC3_CDH2_VEGF BCL2_FRAP1 FRAP1_NNMT_MMP2 FRAP1_LC3_SESN1_STAT3 CDH2_SESN3 FRAP1_LC3_RAGE FRAP1_LC3_CDH2_RAGE FRAP1_RAPTOR FRAP1_CCNG2_CDH2 FRAP1_LC3_NNMT_STAT3 FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 ID2_CDH2_MMP2_SESN3 FRAP1_XIAP FRAP1_CDH2_VEGF FRAP1_LC3_CASP3_STAT3 BECN1_SESN3 FRAP1_LC3_CCNG2 AIFM1_FRAP1_LC3_CDH2 HMGB1_TWIST1 FRAP1_CASP3_MMP2 BCL2L1_FRAP1_LC3_CDH2 ID2_NAMPT BCL2L1_FRAP1_LC3 FRAP1_LC3_PTEN_CDH2 FRAP1_PRKAA1 FRAP1_LC3_SESN1 BAX_FRAP1_LC3_BECN1 ID2_RPS19BP1 FRAP1_CDH2_KIAA1967 BAX_FRAP1_LC3_RPS19BP1 BAX_LC3 AIFM1_FRAP1_LC3 FRAP1_CASP3_CDH2_STAT3 FRAP1_TP63 FRAP1_LC3_RAPTOR LC3_HMGB1_STAT3_TWIST1 ATG12_SESN3 FRAP1_CDH2_RAGE BAX_FRAP1_TKT_CDH2 BAX_TWIST1 BAX_FRAP1_MMP2 FRAP1_LC3_CCNG2_CDH2 RPS19BP1_SESN3 FRAP1_LC3_PTEN FRAP1_TKT_CDH2_SESN1 BAX_MMP2 FRAP1_TKT_CASP3 FRAP1_LC3_HMGB1_TWIST1 SESN1_STAT3 FRAP1_PTEN_CDH2 FRAP1_NNMT_TKT_CDH2 LC3_TWIST1 FRAP1_TKT_TWIST1 BAX_FRAP1_LC3_MMP2 MMP2_NAMPT FRAP1_LC3_KIAA1967 FRAP1_LC3_CCNG2_STAT3 ID2_BECN1 BAX_FRAP1_TKT FRAP1_LC3_STAT3_TWIST1 BCL2L1_LC3 BCL2_FRAP1_CDH2 FRAP1_TKT_CDH2_TWIST1 MMP2_RPS19BP1 FRAP1_HMGB1_TWIST1 FRAP1_LC3_NNMT_MMP2 ATG7_BCL2L1 FRAP1_RPS19BP1_TWIST1 BAX_FRAP1_TKT_MMP2 ID2_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_NNMT_CDH2_MMP2 CDH2_HMGB1 FRAP1_TKT_SESN1 FRAP1_LC3_CDH2_SESN1 CDH2_MMP2 FRAP1_RPS19BP1_SESN1 BAX_FRAP1_LC3_TKT ATG7_TWIST1 BAX_FRAP1_BECN1 FAS_FRAP1_CDH2_SESN1 BAX_SESN3 ID2_NAMPT_SESN3 BAX_FAS_FRAP1_LC3 FASLG_NAMPT FRAP1_CCNG2_STAT3 FRAP1_CASP3_CDH2_MMP2 ATG7_BAX BCL2L1_FRAP1_MMP2 ID2_FASLG_NAMPT_SESN3 TKT_NAMPT BCL2_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1 STAT3_TWIST1 FASLG_NAMPT_SESN3 FRAP1_CDH2_HMGB1_TWIST1 BCL2L1_MMP2 AIFM1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2 LC3_KIAA1967 FRAP1_CCNG2_RPS19BP1 DRAM_ID2_CDH2_SESN3 BAX_BECN1 BAX_FRAP1_RPS19BP1 FRAP1_LC3_RPS19BP1_TWIST1
ATG12_ID2 FAS_FRAP1_SESN1 AIFM1_FRAP1_TKT_CDH2 BECN1_MMP2 BCL2L1_FRAP1_TKT FRAP1_TKT_CCNG2_CDH2 AKT1_BAX FRAP1_NNMT_STAT3 BCL2L1_FRAP1_TKT_CDH2 LC3_RAPTOR FRAP1_MMP2_SESN1 DIABLO_ID2_CDH2_SESN3 BAX_RPS19BP1 FRAP1_ID2_TWIST1 BCL2_FRAP1_LC3_CDH2 BAX_TKT FRAP1_CASP3_STAT3 FRAP1_LC3_CASP3_FASLG BAX_SATB1 FRAP1_TKT_CCNG2 FRAP1_CDH2_RPS19BP1_SESN1 LC3_NAMPT FRAP1_MMP2_VEGF FRAP1_LC3_CASP3_MMP2 KIAA1967_MMP2 FRAP1_MMP2_RAPTOR ID2_CDH2_HMGB2_SESN3 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3 ID2_CDH2_MMP2_RPS19BP1_SESN3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1 FRAP1_LC3_CCNG2_CDH2_STAT3 ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 ID2_CDH2_FASLG_NAMPT_SESN3 AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3 LC3_CDH2_HMGB1_STAT3_TWIST1 ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3 ID2_CDH2_HMGB1_RPS19BP1_SESN3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3 ID2_CDH2_MMP2_NAMPT_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_BECN1_CDH2_KIAA1967 FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 BAX_FRAP1_LC3_CDH2_RPS19BP1 AKT1_ATG12_BECN1_CDH2_STAT3_TP63 ID2_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 ID2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_CDH2_HMGB1_TWIST1 FRAP1_LC3_BECN1_CDH2_RAGE_STAT3 FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3 CSE1L_ID2_CDH2_RPS19BP1_SESN3 ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_SESN1_STAT3 BAX_FAS_FRAP1_LC3_CDH2 FRAP1_LC3_NNMT_CDH2_MMP2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR FRAP1_LC3_NNMT_TKT_CDH2_STAT3 LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_KIAA1967 FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3 AIFM1_FRAP1_LC3_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 FRAP1_LC3_BECN1_CASP3_STAT3 CBS_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3 ID2_CDH2_NAMPT_SESN3_STAT3 AKT1_ATG12_FAS_CDH2_STAT3_TP63 LC3_ID2_NAMPT_RPS19BP1_SESN3 LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FRAP1_LC3_NNMT_MMP2_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1 BAX_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_CASP3_CDH2_MMP2_STAT3 FRAP1_TKT_CASP3_CDH2_STAT3 ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3 LC3_HMGB1_RPS19BP1_STAT3_TWIST1 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_STAT3_VEGF CBS_FRAP1_LC3_CASP3_CDH2 BAX_FRAP1_LC3_TKT_BECN1_CDH2 FRAP1_LAMP1_TKT_CASP3_CDH2 FRAP1_LC3_NNMT_CASP3_CDH2_STAT3 ID2_CDH2_HMGB1_NAMPT_SESN3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3 ID2_HMGB1_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1 FRAP1_LC3_TKT_CDH2_KIAA1967 FRAP1_LC3_BECN1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_HMGB1 ID2_CDH2_FASLG_NAMPT_SESN3_STAT3 ATG7_FRAP1_LC3_CASP3_CDH2 FRAP1_LC3_TKT_CDH2_STAT3_TWIST1 BAX_FRAP1_LC3_TKT_MMP2 ATG5_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3 FRAP1_LC3_RPS19BP1_SESN1_STAT3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1
BAX_FRAP1_LC3_CDH2_MMP2 AIFM1_FRAP1_LC3_TKT_CDH2_STAT3 ID2_TCF3_CDH2_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG FRAP1_TKT_CASP3_CDH2_FASLG DRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3 CBS_ID2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_LC3_CCNG2_CDH2_STAT3 FRAP1_LC3_CDH2_KIAA1967_MMP2 BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1 FAS_FRAP1_LC3_CASP3_CDH2 BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3 BAX_CBS_FRAP1_LC3_CDH2 FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1 FRAP1_LC3_TKT_CDH2_RAPTOR FRAP1_LC3_MMP9_CASP3_CDH2_STAT3 CDH1_ID2_MMP9_TCF3_RPS19BP1 CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3
七种的组合 八种的组合 AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3 ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3 AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3 FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63 ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63 AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1 ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63 FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63 CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1 FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3 CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63 FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3 AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3 FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3 FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1 FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3 AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3 ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63 FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR CSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1
FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3 AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3 ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3 AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3 AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTOR ATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3 FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3 CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3
。
27.如权利要求23所述的方法，所述方法用于预测A1组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表5]
一种 两种的组合 三种的组合 四种的组合 ID2 CDH1_ID2 ATG12_CDH1_ID2 ATG12_CDH1_ID2_HMGB2 CDH1 ATG12_CDH1 CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2 LC3 LAMP1_ID2 ATG12_CDH1_HMGB2 ATG12_CDH1_ID2_AGER TKT BNIP3_ID2 CDH1_ID2_AGER ATG12_CDH1_TCF3_HMGB2 AKT1 ATG12_ID2 DRAM_CDH1_ID2 ATG12_DRAM_CDH1_ID2 AIFM1 CDH1_HMGB2 E2F1_CDH1_ID2 AIFM1_CASP8_LC3_CDH1 BNIP3 ID2_HMGB2 CDH1_ID2_LAMP2 ATG12_CDH1_AGER_HMGB2 LAMP1 E2F1_ID2 TKT_CDH1_ID2 ATG12_CDH1_ID2_BECN1 FRAP1 TKT_ID2 LAMP1_CDH1_ID2 ATG12_DRAM_CDH1_HMGB2 DRAM_ID2 CDH1_ID2_MMP2 DRAM_CDH1_ID2_HMGB2 ATG5_ID2 ATG12_DRAM_CDH1 ATG12_CDH1_BHLHE41_HMGB2 ID2_BECN1 CSE1L_CDH1_ID2 CDH1_ID2_HMGB2_LAMP2 ID2_AGER CDH1_ID2_MMP9 ATG12_CDH1_BECN1_HMGB2 ID2_MMP2 BNIP3_CDH1_ID2 E2F1_CDH1_ID2_HMGB2 ATG3_ID2 CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41 ID2_LAMP2 ATG12_CDH1_BHLHE41 CDH1_ID2_BECN1_HMGB2 ULK1_CDH1 ULK1_CDH1_ID2 ATG12_ATG5_CDH1_HMGB2 CSE1L_ID2 LC3_CDH1_ID2 DRAM_CDH1_ID2_AGER TKT_CDH1 ATG12_CDH1_TCF3 LAMP1_CDH1_ID2_HMGB2 LC3_CDH1 ATG5_CDH1_ID2 ATG12_BNIP3_CDH1_ID2 ID2_MMP9 ATG3_CDH1_ID2 ATG12_CSE1L_CDH1_ID2 LC3_ID2 DIABLO_CDH1_ID2 ATG12_CDH1_ID2_MMP2 FRAP1_ID2 CASP8_CDH1_ID2 ATG12_CASP8_CDH1_ID2 CASP8_ID2 ATG12_ULK1_CDH1 ATG12_ATG3_CDH1_HMGB2 ID2_CIAP2 ATG12_CDH1_BECN1 ATG12_CDH1_ID2_MMP9 ID2_UVRAG ATG12_BNIP3_ID2 CDH1_ID2_HMGB2_MMP2 DIABLO_ID2 CDH1_ID2_CIAP2 ATG12_ATG3_CDH1_ID2 DRAM_CDH1 CBS_CDH1_ID2 ATG12_CASP8_CDH1_HMGB2 ID2_SIRT1 CDH1_ID2_HMGB1 ATG12_LAMP1_CDH1_ID2 FAS_ID2 CDH1_ID2_SIRT1 CDH1_ID2_AGER_BECN1 CDH1_AGER LAMP1_ID2_HMGB2 ATG12_FAS_CDH1_HMGB2 ID2_STAT3 CDH1_ID2_UVRAG ATG12_TKT_CDH1_ID2 CBS_ID2 AIFM1_LC3_CDH1 CDH1_ID2_MMP9_HMGB2 CDH1_MMP2 ATG12_CDH1_AGER ATG12_CDH1_HMGB1_HMGB2 AKT1_ID2 CDH1_ID2_STAT3 ATG12_CDH1_MMP9_HMGB2 ID2_CDH2 ATG12_LAMP1_ID2 ATG12_ATG5_CDH1_ID2 ATG7_ID2 ATG12_LC3_CDH1 ATG5_CDH1_ID2_HMGB2 ID2_HMGB1 CDH1_AGER_HMGB2 ATG3_CDH1_ID2_HMGB2 ULK1_ID2 FAS_CDH1_ID2 ATG12_DIABLO_CDH1_ID2 CDH1_LAMP2 ATG7_CDH1_ID2 CSE1L_CDH1_ID2_HMGB2 ATG5_CDH1 ATG12_CDH1_MMP2 ATG12_CDH1_CIAP2_HMGB2 ID2_SATB1 ATG12_CASP8_CDH1 ATG12_CDH1_ID2_UVRAG
CDH1_MMP9 ATG12_TKT_CDH1 ATG12_CDH1_HMGB2_SESN3 ID2_RPS19BP1 BNIP3_ID2_HMGB2 LC3_CDH1_ID2_AGER ID2_TCF3 E2F1_ID2_HMGB2 ATG12_CDH1_HMGB2_SIRT1 CSE1L_CDH1 ATG12_CDH1_MMP9 ATG12_E2F1_CDH1_ID2 AIFM1_CDH1 ATG12_CDH1_SESN2 ATG12_FAS_CDH1_ID2 ID2_SESN3 CDH1_ID2_CDH2 AIFM1_ATG3_LC3_CDH1 ID2_SESN2 AKT1_CDH1_ID2 ATG12_CDH1_HMGB2_MMP2 LAMP1_CDH1 LAMP1_ID2_BECN1 BNIP3_CDH1_ID2_HMGB2 AIFM1_LC3 CDH1_ID2_TCF3 ATG12_ULK1_CDH1_HMGB2 E2F1_CDH1 ATG12_CDH1_UVRAG TKT_CDH1_ID2_HMGB2 ID2_NAMPT ATG12_FAS_CDH1 ATG12_CDH1_ID2_LAMP2 DIABLO_CDH1 LAMP1_TKT_ID2 ATG12_LC3_CDH1_ID2 BNIP3_CDH1 LAMP1_ID2_AGER ATG12_CDH1_HMGB2_UVRAG AKT1_CDH1 DRAM_LAMP1_ID2 CASP8_CDH1_ID2_HMGB2 CASP8_CDH1 ATG12_DIABLO_CDH1 DIABLO_CDH1_ID2_HMGB2 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 ATG12_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2 DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LAMP1_CDH1_ID2_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_E2F1_CDH1_ID2_HMGB2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_CDH1_ID2_HMGB2 ATG12_LC3_CDH1_ID2_AGER_HMGB2 CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_HMGB2_MMP2 ATG12_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CASP8_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_CDH1_ID2_HMGB2 ATG12_CASP8_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_HMGB2 ATG12_CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_TCF3_AGER_HMGB2 LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2 ATG12_FAS_CDH1_ID2_AGER_HMGB2 CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB1_HMGB2 CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_ATG3_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_CIAP2_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_HMGB2_UVRAG ATG12_DIABLO_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_CDH1_TCF3_HMGB2 ATG12_CASP8_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1 ATG12_DRAM_CDH1_ID2_HMGB2_MMP2 ATG12_DIABLO_CDH1_BHLHE41_HMGB2 ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_HMGB2_SESN3 ATG12_CBS_CDH1_ID2_AGER_HMGB2 ATG12_FAS_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_HMGB2 ATG3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_UVRAG CDH1_ID2_AGER_HMGB2_MMP2 ATG12_E2F1_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_TCF3_HMGB2 ATG12_ATG5_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_TCF3_AGER_HMGB2 ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3 ATG12_CDH1_ID2_HMGB1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2 AIFM1_ATG3_CASP8_LC3_CDH1 ATG12_DRAM_E2F1_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_HMGB2_SIRT1 ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_CDH1_TCF3_BECN1_HMGB2 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1 ATG12_DIABLO_CDH1_TCF3_BHLHE41 ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2 BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3 AIFM1_CASP8_DRAM_LC3_CDH1 AIFM1_ATG3_CASP8_LC3_CDH1_MMP9 ATG12_CDH1_ID2_HMGB2_LAMP2 ATG12_ATG3_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CDH1_TCF3_HMGB2 ATG12_CDH1_ID2_AGER_HMGB2_STAT3 ATG12_LC3_CDH1_ID2_HMGB2 ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2 ATG12_TKT_CDH1_ID2_HMGB2 ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2
CASP8_CDH1_ID2_AGER_HMGB2 DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_TCF3_BHLHE41_HMGB2 DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG5_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2 ATG12_CSE1L_CDH1_ID2_AGER ATG12_BNIP3_CDH1_ID2_BECN1_HMGB2 CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2 CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_LC3_CDH1_ID2_AGER_HMGB2 CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2_MMP2 AIFM1_CASP8_LC3_CDH1_MMP9 DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1 AIFM1_CASP8_DIABLO_LC3_CDH1 ATG12_TKT_CDH1_ID2_AGER_HMGB2 CDH1_ID2_AGER_HMGB1_HMGB2 DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CDH1_ID2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_MMP9_BECN1_HMGB2 ATG12_LC3_CDH1_AGER_HMGB2 CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 FAS_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3_HMGB2
七种的组合 八种的组合 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1 ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2 ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1 ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1 ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2
ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1 ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1 ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3 ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3 AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1 ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1 ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9 ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3 ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1 ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2
。
28.如权利要求23所述的方法，所述方法用于预测A1组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表6]
一种 两种的组合 三种的组合 四种的组合 MMP2 ID2_CDH2 FRAP1_CASP3_CDH2 FRAP1_TKT_CASP3_CDH2 ID2 FRAP1_TWIST1 ID2_CDH2_SESN3 ID2_CDH2_MMP2_SESN3 TWIST1 FRAP1_CASP3 ID2_CDH2_MMP2 CBS_ID2_CDH2_SESN3 BECN1 FRAP1_SESN1 FRAP1_CDH2_TWIST1 FRAP1_TKT_CDH2_TWIST1 BAX BAX_FRAP1 FRAP1_CDH2_SESN1 FRAP1_LC3_CASP3_CDH2 BCL2L1 FRAP1_NNMT FRAP1_NNMT_CDH2 FRAP1_NNMT_TKT_CDH2 CDH2 FRAP1_CCNG2 AIFM1_FRAP1_CDH2 ID2_CDH2_RPS19BP1_SESN3 FASLG BCL2L1_FRAP1 FRAP1_TKT_TWIST1 BAX_FRAP1_TKT_CDH2 AGER FRAP1_RAGE BAX_FRAP1_CDH2 BAX_FRAP1_LC3_CDH2 ATG12 AIFM1_FRAP1 FRAP1_LC3_TWIST1 ATG12_ID2_CDH2_SESN3 TKT BCL2_FRAP1 AKT1_ID2_CDH2 ATG12_ID2_MMP2_SESN3 FRAP1_VEGF ATG12_ID2_MMP2 FRAP1_LC3_CDH2_KIAA1967 FRAP1_PTEN FRAP1_CDH2_KIAA1967 AIFM1_FRAP1_TKT_CDH2 HMGB1_TWIST1 FRAP1_CCNG2_CDH2 FRAP1_TKT_CDH2_SESN1 ATG12_ID2 FRAP1_NNMT_MMP2 ID2_MMP2_RPS19BP1_SESN3 FRAP1_RAPTOR FRAP1_CDH2_RAGE FRAP1_CDH2_SESN1_STAT3 FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1 ID2_BECN1 FRAP1_TKT_CASP3 FRAP1_LC3_NNMT_CDH2 BECN1_SESN3 ATG12_MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR ATG12_MMP2 FRAP1_CDH2_VEGF FRAP1_TKT_CCNG2_CDH2 CDH2_SESN3 ID2_CDH2_HMGB1 DIABLO_ID2_CDH2_SESN3 ID2_MMP2 FRAP1_PTEN_CDH2 ID2_CDH2_HMGB2_SESN3 FRAP1_XIAP CDH1_ID2_CDH2 FRAP1_TKT_CDH2_KIAA1967 AKT1_CDH2 FRAP1_CASP3_MMP2 FRAP1_LC3_CDH2_RAGE FRAP1_PRKAA1 FRAP1_LC3_CASP3 BAX_FRAP1_TKT_MMP2 ID2_RPS19BP1 BCL2_FRAP1_CDH2 BCL2L1_FRAP1_TKT_CDH2 TKT_MMP2 BAX_FRAP1_TKT FRAP1_CASP3_CDH2_STAT3 BAX_TWIST1 FRAP1_CDH2_RAPTOR FRAP1_PTEN_TKT_CDH2 BECN1_FASLG BAX_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1 ATG12_SESN3 BAX_FRAP1_MMP2 ID2_CDH2_NAMPT_SESN3 CDH2_MMP2 FAS_ID2_CDH2 FRAP1_TKT_CDH2_VEGF BECN1_MMP2 FRAP1_RPS19BP1_TWIST1 FRAP1_LC3_CDH2_VEGF BAX_MMP2 FRAP1_LC3_NNMT FRAP1_NNMT_CDH2_MMP2 ID2_NAMPT FRAP1_LC3_RAGE AIFM1_FRAP1_LC3_CDH2 CASP8_ID2 FRAP1_HMGB1_TWIST1 FRAP1_LC3_PTEN_CDH2 ID2_TWIST1 FRAP1_SESN1_STAT3 FRAP1_TKT_CDH2_RAGE MMP2_SESN3 FRAP1_TKT_SESN1 FRAP1_CDH2_HMGB1_TWIST1 AKT1_BAX ATG3_ID2_CDH2 FAS_FRAP1_CDH2_SESN1
FRAP1_TP63 FRAP1_ID2_CDH2 FRAP1_CASP3_CDH2_MMP2 BAX_LC3 FRAP1_TKT_CCNG2 DRAM_ID2_CDH2_SESN3 ATG12_FASLG FAS_FRAP1_TWIST1 LC3_HMGB1_STAT3_TWIST1 LC3_TWIST1 FRAP1_NNMT_TKT CASP8_ID2_CDH2_SESN3 AKT1_TWIST1 AIFM1_FRAP1_MMP2 FRAP1_TKT_CDH2_RAPTOR ID2_FASLG ID2_CDH2_CIAP2 BCL2L1_FRAP1_LC3_CDH2 STAT3_TWIST1 FRAP1_LC3_VEGF FRAP1_CDH2_KIAA1967_MMP2 TKT_FASLG CDH2_MMP2_SESN3 FRAP1_TKT_CASP3_FASLG AKT1_ATG12 ID2_CDH2_FASLG TKT_ID2_CDH2_MMP2 MMP2_NAMPT CBS_ID2_CDH2 FRAP1_NNMT_TKT_MMP2 ID2_SIRT1 FRAP1_LC3_CCNG2 FRAP1_TKT_CASP3_MMP2 ID2_AGER BCL2L1_FRAP1_TKT ID2_CDH2_CIAP2_SESN3 ATG7_TWIST1 FRAP1_ID2_TWIST1 FRAP1_CDH2_STAT3_TWIST1 AKT1_BCL2L1 AIFM1_FRAP1_LC3 CBS_FRAP1_CASP3_CDH2 BAX_TKT AIFM1_FRAP1_TKT BAX_FRAP1_CDH2_MMP2 KIAA1967_MMP2 ATG5_ID2_CDH2 ATG12_TKT_MMP2_SESN3 BCL2L1_MMP2 FRAP1_TKT_RAGE FRAP1_CDH1_CASP3_CDH2 ATG7_TP63 BCL2L1_FRAP1_MMP2 BAX_FRAP1_BECN1_CDH2 LC3_BECN1 FRAP1_CDH2_TP63 ID2_CDH2_HMGB1_MMP2 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_CDH2_STAT3_TP63 ATG12_ID2_CDH2_MMP2_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_CASP3_CDH2_STAT3 AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63 ATG12_ID2_MMP2_RPS19BP1_SESN3 AKT1_FAS_LC3_CDH2_STAT3_TP63 AKT1_FAS_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_BECN1_CDH2_STAT3_TP63 CASP8_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63 FRAP1_TKT_CASP3_CDH2_FASLG ATG12_ID2_CDH2_HMGB1_MMP2_SESN3 BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3 DIABLO_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FRAP1_LAMP1_TKT_CASP3_CDH2 ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3 CBS_ID2_CDH2_MMP2_SESN3 ATG12_ID2_CDH2_CIAP2_MMP2_SESN3 FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3 FRAP1_TKT_CDH2_SESN1_STAT3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3 LC3_CDH2_HMGB1_STAT3_TWIST1 ATG12_FRAP1_ID2_CDH2_MMP2_SESN3 DRAM_ID2_CDH2_MMP2_SESN3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1 FRAP1_LC3_CDH2_SESN1_STAT3 ATG12_TKT_ID2_CDH2_MMP2_SESN3 CBS_FRAP1_TKT_CASP3_CDH2 ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3 ID2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ID2_CDH2_RPS19BP1_SESN3 AKT1_FAS_CASP3_CDH2_STAT3_TP63 ID2_CDH2_MMP2_NAMPT_SESN3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3 AKT1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_TKT_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR ATG12_ID2_CDH2_MMP2_SESN3_STAT3 FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_NNMT_TKT_BECN1_CDH2_STAT3 BAX_FRAP1_TKT_CDH2_MMP2 ATG12_FAS_FRAP1_CDH2_STAT3_TP63 FAS_FRAP1_LC3_CDH2_KIAA1967 ATG12_ATG3_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_CDH2_RPS19BP1_TP63 DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3 FAS_FRAP1_LC3_CDH2_RAGE ATG12_CBS_ID2_CDH2_MMP2_SESN3 FAS_LC3_HMGB1_STAT3_TWIST1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3 FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CASP3_CDH2_CIAP2 AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3 TKT_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_TKT_CDH2_KIAA1967_MMP2 ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CDH2_HMGB1_TWIST1 AKT1_FAS_CDH2_HMGB1_STAT3_TP63 BAX_FRAP1_LC3_BECN1_CDH2 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CDH2_STAT3_TWIST1 ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_ID2_CDH2_SESN3 FRAP1_LC3_NNMT_TKT_CDH2_STAT3 BAX_FAS_FRAP1_LC3_CDH2 CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3
ATG12_CBS_ID2_MMP2_SESN3 AKT1_ATG12_CDH2_HMGB1_STAT3_TP63 FAS_FRAP1_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 FRAP1_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_TKT_CDH2_SESN1 ATG12_ATG5_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_CCNG2_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_STAT3_TP63 ID2_CDH2_MMP2_SESN3_UVRAG AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63 ATG7_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR ID2_CDH2_HMGB1_RPS19BP1_SESN3 FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_TKT_CDH2_MMP2_RAPTOR ATG12_CDH1_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_TKT_CDH2_STAT3_TWIST1 ATG12_ID2_CDH2_FASLG_SESN3 CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3 ATG7_FRAP1_TKT_CASP3_CDH2 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1 FRAP1_TKT_CASP3_CDH2_MMP2 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1 FRAP1_LC3_CDH2_HMGB1_TWIST1 ATG12_ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CDH2_KIAA1967 ATG12_FAS_ID2_CDH2_MMP2_SESN3 ATG7_ID2_CDH2_RPS19BP1_TP63 TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3 BAX_FRAP1_TKT_BECN1_CDH2 BAX_FAS_FRAP1_LC3_TKT_CDH2 ATG3_FRAP1_TKT_CASP3_CDH2 ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF3_CDH2 CDH1_ID2_MMP9_TCF3_CDH2_SESN3
七种的组合 八种的组合 AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63 AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63 AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63 AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63
AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63 AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63 FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STATS_TP63 ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 AKT1_ATG12_CASP8FAS_NNMT_CDH2_STAT3_TP63 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63 FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63 AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63 AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63 AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8FAS_CDH2_CIAP2_STAT3_TP63 CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3 AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3
。
29.如权利要求23所述的方法，所述方法用于预测A2组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表7]
一种 两种的组合 三种的组合 四种的组合 TKT PRKAA1_LAMP2 LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1 SESN2 TKT_SESN2 BNIP3_PRKAA1_LAMP2 ATG3_LC3_SESN2_SIRT1 LAMP2 ATG7_LAMP2 ATG5_LC3_SESN2 CSE1L_LC3_SESN2_SIRT1 LAMP2_SESN2 BNIP3_LC3_SESN2 ATG5_CSE1L_LC3_SESN2 AKT1_PRKAA1 ATG7_LC3_SESN2 BNIP3_LC3_SESN2_SIRT1 SESN2_SIRT1 AKT1_PRKAA1_LAMP2 FRAP1_LC3_SESN2_SIRT1 TKT_VEGF ATG7_TKT_SESN2 AKT1_ATG3_PRKAA1_LAMP2 ATG7_TKT DRAM_LC3_SESN2 ATG3_ATG5_LC3_SESN2 TKT_LAMP2 PRKAA1_AGER_LAMP2 ATG7_LC3_SESN2_SIRT1 BHLHE41_SESN2 PRKAA1_TKT_LAMP2 BNIP3_CSE1L_LC3_SESN2 TKT_BHLHE41 ATG7_TKT_LAMP2 TKT_LAMP2_SESN2_SIRT1 ATG5_SESN2 TKT_LAMP2_SESN2 CIAP2_LAMP2_SESN2_SIRT1 LAMP1_SESN2 TKT_LAMP2_VEGF ATG12_TKT_LAMP2_SESN2 CSE1L_LAMP2 ATG12_LC3_SESN2 ATG7_TKT_LAMP2_SESN2 ATG12_SESN2 ATG7_LAMP2_SESN2 AKT1_ATG7_PRKAA1_LAMP2 AKT1_TKT TKT_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2 E2F1_SESN2 E2F1_LC3_SESN2 ATG3_BNIP3_LC3_SESN2 ATG3_LAMP2 LC3_SESN2_UVRAG AKT1_PRKAA1_LAMP2_UVRAG BNIP3_SESN2 PRKAA1_CCNG2_LAMP2 DRAM_LC3_SESN2_SIRT1 LC3_SESN2 AKT1_ATG7_TKT ATG7_CSE1L_LC3_SESN2 TWIST1_VEGF ATG5_PRKAA1_LAMP2 ATG7_FRAP1_LC3_SESN2 ATG7_LC3 ATG3_LAMP2_SESN2 BNIP3_PRKAA1_LAMP2_SESN2 CSE1L_SESN2 BNIP3_TKT_SESN2 ATG5_ATG7_LC3_SESN2 ATG5_LC3 LAMP2_SESN2_SIRT1 PRKAA1_TKT_LAMP2_SESN2 ATG7_SESN2 ATG7_PRKAA1_LAMP2 ATG3_ATG7_LC3_SESN2 LC3_ULK1 LAMP1_LC3_SESN2 BNIP3_PRKAA1_AGER_LAMP2 ATG3_TKT ATG12_PRKAA1_LAMP2 E2F1_LC3_SESN2_SIRT1 DRAM_SESN2 CASP8_PRKAA1_LAMP2 LC3_ID2_SESN2_SIRT1 PRKAA1_TKT AIFM1_TKT_SESN2 LC3_NAMPT_SESN2_SIRT1 BHLHE41_LAMP2 FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2 LAMP2_VEGF PRKAA1_HMGB1_LAMP2 ATG7_BNIP3_LC3_SESN2 AKT1_VEGF LC3_BHLHE41_SESN2 LC3_RPS19BP1_SESN2_SIRT1 TKT_CIAP2 ATG12_TKT_SESN2 AKT1_ATG7_TKT_SESN2 CSE1L_BHLHE41 CSE1L_LAMP2_SESN2 BCL2L1_BNIP3_PRKAA1_LAMP2
LC3_BHLHE41 PRKAA1_CASP3_LAMP2 CSE1L_DRAM_LC3_SESN2 LC3_SIRT1 PRKAA1_LAMP2_RAGE DIABLO_LC3_SESN2_SIRT1 CSE1L_LAMP1 PRKAA1_LAMP2_SESN2 LC3_SESN2_SIRT1_STAT3 TKT_RPS19BP1 TKT_CIAP2_SESN2 ATG12_ATG5_LC3_SESN2 CBS_TKT BCL2L1_PRKAA1_LAMP2 BNIP3_PRKAA1_TCF3_LAMP2 CSE1L_BECN1 DIABLO_PRKAA1_LAMP2 LC3_SESN2_SIRT1_UVRAG TKT_CDH1 PRKAA1_CDH1_LAMP2 BNIP3_PRKAA1_MMP9_LAMP2 TKT_HMGB1 CBS_PRKAA1_LAMP2 AKT1_LC3_SESN2_SIRT1 TKT_RAGE CSE1L_SESN2_SIRT1 AKT1_PRKAA1_CDH1_LAMP2 AIFM1_SESN2 ATG3_PRKAA1_LAMP2 CSE1L_LAMP1_LC3_SESN2 ATG7_TWIST1 PRKAA1_FASLG_LAMP2 ATG7_PRKAA1_TKT_LAMP2 BHLHE41_NAMPT PRKAA1_ID2_LAMP2 KIAA1967_LAMP2_SESN2_SIRT1 BNIP3_LC3 PRKAA1_LAMP2_SATB1 LC3_SESN2_SESN3_SIRT1 PRKAA1_SESN2 PRKAA1_LAMP2_SESN1 BNIP3_PRKAA1_HMGB1_LAMP2 ATG7_NAMPT AKT1_ATG7_PTEN CSE1L_LC3_SESN2_UVRAG BECN1_SESN2 ATG7_TKT_BHLHE41 LC3_MMP9_SESN2_SIRT1 TKT_HMGB2 PRKAA1_LAMP2_MMP2 ATG3_LAMP2_SESN2_SIRT1 TKT_SIRT1 CSE1L_LAMP1_SESN2 BNIP3_PRKAA1_CCNG2_LAMP2 ATG5_CSE1L PRKAA1_LAMP2_SESN3 BNIP3_PRKAA1_LAMP2_SATB1 SESN2_UVRAG ATG3_TKT_SESN2 BNIP3_PRKAA1_LAMP2_SESN1 TKT_CASP3 ATG5_CSE1L_SESN2 ATG5_DRAM_LC3_SESN2 TKT_CDH2 ATG5_CSE1L_LC3 BNIP3_PRKAA1_CASP3_LAMP2 TKT_MMP2 FRAP1_PRKAA1_LAMP2 BNIP3_FRAP1_LC3_SESN2
五种的组合 六种的组合 CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_LC3_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_FRAP1_LC3_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 TKT_CIAP2_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 TKT_CDH1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_BNIP3_LC3_SESN2_SIRT1 ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_CSE1L_LC3_SESN2_SIRT1 FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_LC3_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 BNIP3_FRAP1_LC3_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BNIP3_PRKAA1_TKT_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2_SIRT1 ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_ATG7_LC3_SESN2_SIRT1 BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_TKT_LAMP2_SESN2 CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1 AKT1_ATG7_BNIP3_PRKAA1_LAMP2 ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_SESN2_SIRT1 CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_BNIP3_LC3_SESN2 FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BNIP3_CSE1L_LC3_SESN2_SIRT1 MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_DRAM_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 AIFM1_CIAP2_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_TKT_LAMP2_SESN2_SIRT1 CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2 LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_LC3_NAMPT_SESN2_SIRT1 TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_E2F1_LC3_SESN2_SIRT1 ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1 ATG7_LC3_LAMP2_SESN2_SIRT1 ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1 AIFM1_BNIP3_PRKAA1_LAMP2_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG12_BNIP3_TKT_LAMP2_SESN2 ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_KIAA1967_LAMP2_SESN2_SIRT1 E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG12_ATG5_BNIP3_LC3_SESN2 ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_LAMP2_SESN2 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG12_TKT_CIAP2_LAMP2_SESN2 ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1
ATG5_BNIP3_CSE1L_LC3_SESN2 TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1 AKT1_ATG7_PRKAA1_TKT_LAMP2 ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_LC3_NAMPT_SESN2_SIRT1 ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1 ATG3_CSE1L_LC3_SESN2_SIRT1 AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_LC3_ID2_SESN2_SIRT1 CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1 BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_ID2_SESN2_SIRT1 ATG3_LC3_ID2_SESN2_SIRT1 AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_TKT_LAMP2_SESN2_SIRT1 ATG3_ATG5_E2F1_LC3_SESN2_SIRT1 LC3_CIAP2_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1 ATG12_TKT_CDH1_LAMP2_SESN2 ATG3_ATG5_LC3_SESN2_SIRT1_STAT3 ATG5_LC3_SESN2_SIRT1_STAT3 AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG ATG3_DRAM_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1 ATG5_DIABLO_LC3_SESN2_SIRT1 ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1 ATG7_BNIP3_LC3_SESN2_SIRT1 ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1 CDH2_CIAP2_LAMP2_SESN2_SIRT1 TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2 ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1 DRAM_TKT_LAMP2_SESN2_SIRT1 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG12_ATG3_TKT_LAMP2_SESN2 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1_UVRAG AIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合 八种的组合 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3 CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1 ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1 AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1 BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3 ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN1_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1 AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1
FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1 ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1 LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1 FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1
。
30.如权利要求23所述的方法，所述方法用于预测A2组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表8]
一种 两种的组合 三种的组合 四种的组合 BCL2L1 BCL2L1_NNMT BCL2L1_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1 FAS BCL2L1_E2F1 BCL2L1_E2F1_PRKAA1 BCL2L1_TKT_CASP3_SESN2 LAMP1 BCL2L1_TKT ATG3_BCL2L1_PRKAA1 BCL2L1_ID2_CASP3_SESN2 BHLHE41 FAS_LAMP1 ATG3_BCL2L1_NNMT ATG3_BCL2L1_E2F1_PRKAA1 TKT BCL2L1_PRKAA1 ATG3_BCL2L1_E2F1 BCL2L1_NNMT_PRKAA1_HMGB1 LC3 FAS_BHLHE41 FAS_BHLHE41_SESN2 BCL2L1_NNMT_PRKAA1_MMP2 SESN2 FAS_TKT BCL2L1_PRKAA1_HMGB2 BCL2L1_NNMT_PRKAA1_CDH1 BCL2L1_CASP3 BCL2L1_CASP3_SESN2 FAS_TKT_CASP3_SESN2 ATG3_BCL2L1 BCL2L1_PRKAA1_TKT BCL2L1_NNMT_PRKAA1_VEGF ATG7_BCL2L1 FAS_CASP3_SESN2 ATG7_BCL2L1_NNMT_PRKAA1 FAS_CASP3 BCL2L1_TKT_CASP3 BCL2L1_FRAP1_NNMT_PRKAA1 TKT_BHLHE41 FAS_TKT_CASP3 BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_KIAA1967 BCL2L1_E2F1_TKT AIFM1_BCL2L1_NNMT_PRKAA1 FAS_PRKAA1 BCL2L1_NNMT_TKT BCL2L1_TKT_BHLHE41_CASP3 FAS_KIAA1967 FAS_TKT_BHLHE41 BCL2L1_NNMT_PRKAA1_CDH2 FAS_SESN2 FAS_TKT_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1 BCL2L1_HMGB2 FAS_LAMP1_BHLHE41 BCL2L1_NNMT_PRKAA1_HMGB2 BCL2L1_VEGF FAS_LAMP1_SESN2 BCL2L1_CBS_NNMT_PRKAA1 BNIP3_FAS ATG3_BCL2L1_TKT FAS_TKT_SESN2_TP63 FAS_TWIST1 ATG7_BCL2L1_PRKAA1 BCL2L1_DRAM_NNMT_PRKAA1 BNIP3_TKT DIABLO_FAS_BHLHE41 BCL2L1_NNMT_PRKAA1_ULK1 BCL2L1_CSE1L TKT_SESN2_TP63 BNIP3_TKT_CASP3_SESN2 TKT_SESN2 FAS_PRKAA1_TKT ATG5_BCL2L1_NNMT_PRKAA1 BCL2L1_FRAP1 ATG7_BCL2L1_NNMT BCL2L1_DIABLO_NNMT_PRKAA1 LAMP1_SESN2 BCL2L1_BNIP3_TKT BCL2L1_NNMT_CASP3_SESN2 LC3_BHLHE41 BNIP3_FAS_TKT FAS_TKT_BHLHE41_CASP3 BCL2L1_BNIP3 BCL2L1_NNMT_CASP3 BCL2L1_NNMT_PRKAA1_TKT BCL2L1_LC3 TKT_BHLHE41_CASP3 BNIP3_FAS_TKT_CASP3 ATG5_BCL2L1 ATG3_BCL2L1_CASP3 ATG3_ATG7_BCL2L1_PRKAA1 BCL2L1_CBS BCL2L1_PRKAA1_CASP3 FAS_ID2_CASP3_SESN2
CSE1L_LAMP1 BCL2L1_PRKAA1_MMP2 BCL2L1_NNMT_PRKAA1_CASP3 E2F1_FAS FAS_BHLHE41_CASP3 ATG3_BCL2L1_PRKAA1_HMGB2 AIFM1_BCL2L1 FAS_TKT_KIAA1967 FAS_LC3_BHLHE41_SESN2 BHLHE41_SESN2 FAS_TKT_TWIST1 ATG3_BCL2L1_BNIP3_NNMT CASP8_FAS BCL2L1_E2F1_NNMT BCL2L1_CASP8_NNMT_PRKAA1 FAS_NAMPT BCL2L1_FRAP1_NNMT FAS_BHLHE41_CASP3_SESN2 FAS_TP63 BCL2L1_TKT_BHLHE41 BCL2L1_BNIP3_NNMT_TKT LAMP1_BHLHE41 BCL2L1_TKT_SESN2 DIABLO_FAS_BHLHE41_SESN2 ATG12_FAS FAS_KIAA1967_SESN2 ATG3_BCL2L1_PRKAA1_TKT BCL2L1_MMP2 DIABLO_FAS_LAMP1 BCL2L1_NNMT_PRKAA1_MMP9 BHLHE41_CASP3 ATG3_BCL2L1_KIAA1967 BNIP3_FAS_CASP3_SESN2 FAS_HMGB1 ATG7_BCL2L1_E2F1 FAS_LAMP1_BHLHE41_SESN2 FAS_VEGF FAS_BHLHE41_SATB1 BCL2L1_CASP3_SESN1_SESN2 LAMP1_TCF3 ATG3_ATG7_BCL2L1 BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_ULK1 ATG7_BCL2L1_TKT DIABLO_FAS_LAMP1_BHLHE41 FAS_LC3 BCL2L1_BNIP3_NNMT FAS_TKT_CASP3_SIRT1 NNMT_BHLHE41 BCL2L1_PRKAA1_VEGF E2F1_FAS_BHLHE41_SESN2 BCL2L1_FAS BCL2L1_BHLHE41_CASP3 FAS_TKT_CASP3_FASLG TKT_TP63 FAS_SESN2_TP63 FAS_TKT_HMGB1_SESN2 AKT1_BCL2L1 TKT_BHLHE41_TP63 FAS_CASP3_HMGB1_SESN2 ATG12_BCL2L1 AIFM1_BCL2L1_NNMT BAX_BCL2L1_NNMT_PRKAA1 FAS_HMGB2 BCL2L1_CSE1L_NNMT BCL2L1_E2F1_NNMT_PRKAA1 BCL2L1_ID2 BCL2L1_E2F1_FRAP1 ATG3_BCL2L1_PRKAA1_MMP2 BCL2L1_RPS19BP1 BNIP3_FAS_CASP3 FAS_TKT_KIAA1967_SESN2 TKT_SATB1 FAS_TKT_SATB1 BNIP3_FAS_TKT_TWIST1 FAS_XIAP BCL2L1_CSE1L_PRKAA1 ATG3_BCL2L1_BNIP3_TKT BCL2_BCL2L1 BCL2L1_NNMT_VEGF BCL2L1_NNMT_PRKAA1_PTEN
五种的组合 六种的组合 BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1 ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2 BCL2L1_TKT_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN2 FAS_TKT_CASP3_HMGB1_SESN2_TP63 ATG3_BCL2L1_NNMT_PRKAA1_CDH1 ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1 BCL2L1_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ULK1 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF FAS_TKT_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2 FAS_TKT_CASP3_SESN2_TP63 BCL2L1_NNMT_ID2_AGER_CASP3_SESN2 ATG3_BCL2L1_FRAP1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2 FAS_TKT_HMGB1_SESN2_TP63 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2 AIFM1_ATG3_BCL2L1_NNMT_PRKAA1 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_ID2_CASP3_SESN1_SESN2 ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_MMP2 BNIP3_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_TKT_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_VEGF AIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_TKT_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2 BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG BCL2L1_NNMT_PRKAA1_HMGB1_VEGF BCL2L1_NNMT_ID2_CASP3_SESN2_SESN3 ATG3_BCL2L1_NNMT_PRKAA1_CDH2 BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_LAMP1_NNMT_PRKAA1 BAX_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_SESN2_UVRAG BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1 BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2 ATG3_BCL2L1_CBS_NNMT_PRKAA1 BNIP3_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2 BNIP3_FAS_TKT_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2
ATG3_BCL2L1_DRAM_NNMT_PRKAA1 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2 ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_FAS_TKT_CASP3_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2 ATG3_BCL2L1_CSE1L_NNMT_PRKAA1 ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF ATG3_BCL2L1_DIABLO_NNMT_PRKAA1 BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_CASP8_ID2_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_DIABLO_ID2_CASP3_SESN2 BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2 BCL2L1_TKT_CASP3_SESN2_STAT3 BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_VEGF BCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2 BCL2L1_ID2_CASP3_HMGB2_SESN2 BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_CASP3_SESN2_SESN3 BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2 BCL2L1_TKT_CASP3_CCNG2_SESN2 BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2 FAS_TKT_CASP3_FASLG_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2 FAS_TKT_CASP3_SESN2_SIRT1 BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2 BCL2L1_NNMT_ID2_KIAA1967_SESN2 BNIP3_FAS_TKT_CASP3_HMGB1_SESN2 ATG5_BCL2L1_ID2_CASP3_SESN2 FAS_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG BCL2L1_TKT_XIAP_BHLHE41_CASP3 FAS_TKT_HMGB1_KIAA1967_SESN2_TP63 FAS_TKT_XIAP_CASP3_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_CDH1_ID2_CASP3_SESN2 BCL2L1_PTEN_TKT_ID2_CASP3_SESN2 BCL2L1_TKT_CASP3_SESN2_SIRT1 BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2 ATG7_BCL2L1_NNMT_PRKAA1_ID2 BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2_BCL2L1_TKT_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_ID2_CASP3_CDH2_SESN2 BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2
七种的组合 八种的组合 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2 BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2 ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2 BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3 ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2 BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2 BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2 BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2
BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2 BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2 BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2 BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2 BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2 BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2 BCL2L1_NNMT_ID2AGER_CASP3_RAGE_SESN2 AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2 BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2 ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 BCL2L1_CASP8_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967 BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3 BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3 BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2 BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2 BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2
。
31.如权利要求23所述的方法，所述方法用于预测A2组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表9]
一种 两种的组合 三种的组合 四种的组合 SESN2 TKT_SESN2 ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2 TKT BHLHE41_SESN2 FRAP1_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1 LAMP2 LAMP2_SESN2 ATG5_LC3_SESN2 ATG7_TKT_LAMP2_SESN2 BHLHE41 ATG5_SESN2 ATG5_FRAP1_SESN2 ATG5_FRAP1_SESN2_SIRT1 CSE1L LAMP1_SESN2 TKT_LAMP2_SESN2 AKT1_ATG7_TKT_SESN2 SESN2_SIRT1 AIFM1_TKT_SESN2 ATG5_CSE1L_LC3_SESN2 E2F1_SESN2 ATG5_CSE1L_SESN2 FRAP1_LC3_SESN2_SIRT1 ATG12_SESN2 LC3_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_SESN2 TKT_VEGF ATG12_TKT_SESN2 ATG7_TKT_SESN2_SESN3 CSE1L_BECN1 CSE1L_LAMP1_SESN2 ATG5_FRAP1_LC3_SESN2 CSE1L_SESN2 TKT_HMGB2_SESN2 ATG7_CSE1L_FRAP1_SESN2 ATG7_TKT ATG5_TKT_SESN2 CSE1L_LC3_SESN2_SIRT1 FASLG_SESN2 TKT_CDH1_SESN2 ATG5_LC3_SESN2_SIRT1 PRKAA1_LAMP2 TKT_SESN2_SESN3 ATG7_TKT_FASLG_SESN2 PRKAA1_SESN2 TKT_SESN2_VEGF ATG7_TKT_AGER_SESN2 TKT_BHLHE41 CSE1L_BHLHE41_SESN2 ATG7_TKT_HMGB1_SESN2 CSE1L_BHLHE41 PRKAA1_TKT_SESN2 ATG7_TKT_MMP2_SESN2 ATG7_SESN2 ATG3_TKT_SESN2 BNIP3_CSE1L_FRAP1_SESN2 CSE1L_LAMP2 TKT_RPS19BP1_SESN2 ATG5_ATG7_TKT_SESN2 FAS_SESN2 CBS_TKT_SESN2 ATG7_BCI2_TKT_SESN2 HMGB2_SESN2 CSE1L_LAMP2_SESN2 ATG7_BNIP3_TKT_SESN2 CSE1L_LAMP1 TKT_SESN2_SIRT1 FAS_FRAP1_SESN2_SIRT1 BECN1_SESN2 AKT1_TKT_SESN2 AIFM1_ATG7_TKT_SESN2 NNMT_SESN2 CSE1L_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2 AIFM1_SESN2 TKT_CDH2_SESN2 ATG7_TKT_BHLHE41_SESN2 BAX_SESN2 BNIP3_TKT_SESN2 ATG7_TKT_ID2_SESN2 DRAM_SESN2 NNMT_TKT_SESN2 CSE1L_DRAM_FRAP1_SESN2
CSE1L_ULK1 TKT_AGER_SESN2 CSE1L_FRAP1_SESN2_UVRAG KIAA1967_SESN2 TKT_BHLHE41_SESN2 ATG7_LAMP1_TKT_SESN2 SESN2_VEGF TKT_HMGB1_SESN2 ATG7_BCL2L1_TKT_SESN2 BNIP3_SESN2 TKT_MMP2_SESN2 ATG7_TKT_CCNG2_SESN2 SESN2_UVRAG E2F1_TKT_SESN2 CSE1L_E2F1_FRAP1_SESN2 TWIST1_VEGF NAMPT_SESN2_SIRT1 CSE1L_LAMP1_LC3_SESN2 PRKAA1_FASLG TKT_KIAA1967_SESN2 PRKAA1_TKT_LAMP2_SESN2 TKT_RPS19BP1 DRAM_TKT_SESN2 ATG7_CBS_TKT_SESN2 PRKAA1_TKT TKT_CIAP2_SESN2 ATG7_LC3_TKT_SESN2 ATG7_LAMP2 TKT_MMP9_SESN2 ATG7_NNMT_TKT_SESN2 AGER_SESN2 ATG5_NAMPT_SESN2 ATG7_TKT_CIAP2_SESN2 CDH2_SESN2 ATG7_FRAP1_SESN2 ATG7_TKT_SESN2_STAT3 AKT1_PRKAA1 CSE1L_E2F1_SESN2 ATG7_PTEN_TKT_SESN2 ULK1_SESN2 LAMP1_TKT_SESN2 ATG7_TKT_CASP3_SESN2 MMP2_SESN2 LC3_TKT_SESN2 ATG7_TKT_CDH2_SESN2 ATG5_CSE1L TKT_CASP3_SESN2 ATG7_TKT_HMGB2_SESN2 HMGB1_SESN2 TKT_CCNG2_SESN2 ATG7_TKT_NAMPT_SESN2 AKT1_TKT TKT_ID2_SESN2 ATG7_TKT_RAPTOR_SESN2 CBS_SESN2 TKT_RAPTOR_SESN2 ATG7_TKT_SESN2_SIRT1 FRAP1_SESN2 TKT_XIAP_SESN2 ATG7_FRAP1_LC3_SESN2 CIAP2_SESN2 BAX_TKT_SESN2 ATG7_TKT_BECN1_SESN2 BCL2_SESN2 BCL2_TKT_SESN2 ATG7_DIABLO_TKT_SESN2 CCNG2_SESN2 ATG12_CSE1L_SESN2 ATG7_FRAP1_SESN2_SIRT1 BCL2L1_SESN2 BCL2L1_TKT_SESN2 ATG12_CSE1L_FRAP1_SESN2 CSE1L_UVRAG CASP8_TKT_SESN2 ATG7_TKT_XIAP_SESN2 RAPTOR_SESN2 DIABLO_TKT_SESN2 ATG7_E2F1_TKT_SESN2 XIAP_SESN2 FAS_BHLHE41_SESN2 ATG7_TKT_MMP9_SESN2 CASP3_SESN2 FRAP1_TKT_SESN2 ATG7_TKT_RAGE_SESN2 CASP8_SESN2 PTEN_TKT_SESN2 ATG3_ATG7_TKT_SESN2 LC3_SESN2 TKT_RAGE_SESN2 ATG7_CSE1L_LC3_SESN2
五种的组合 六种的组合 ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG7_CSE1L_FRAP1_LC3_SESN2 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AKT1_ATG7_TKT_LAMP2_SESN2 ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG5_FRAP1_LAMP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 CSE1L_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2 ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG5_CSE1L_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG7_TKT_LAMP2_SESN2_SESN3 AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_SATB1_SESN2_SIRT1 ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_CDH1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG7_TKT_FASLG_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_ID2_SESN2 CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_SESN2_SESN3 CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG7_TKT_LAMP2_MMP2_SESN2 CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_CSE1L_FRAP1_SESN2_SIRT1 AKT1_ATG5_FRAP1_LC3_SESN2_SI RT1 BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3 ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_SESN2 ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 CSE1L_DRAM_FRAP1_LC3_SESN2 ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2
ATG5_ATG7_FRAP1_LC3_SESN2 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2 ATG5_FAS_FRAP1_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 CSE1L_FRAP1_SESN2_SESN3_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_DRAM_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_DIABLO_FRAP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2 ATG7_CSE1L_FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 ATG5_CSE1L_FRAP1_CDH1_SESN2 ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1 ATG7_TKT_FASLG_SESN2_SESN3 ATG5_CSE1L_FRAP1_CDH1_SESN2_SIRT1 ATG7_TKT_HMGB1_LAMP2_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG7_TKT_AGER_LAMP2_SESN2 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2 ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_FRAP1_SESN2_SIRT1 ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SATB1_SESN2 ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_ID2_SESN2_SIRT1 CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG7_BNIP3_TKT_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3 ATG5_ATG7_CSE1L_FRAP1_SESN2 AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2 ATG5_LC3_NAMPT_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG ATG12_ATG5_CSE1L_FRAP1_SESN2 CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1_STAT3 CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_UVRAG ATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2 AKT1_ATG7_TKT_MMP2_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG5_BNIP3_CSE1L_FRAP1_SESN2 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2 CSE1L_FRAP1_MMP9_SESN2_SIRT1 CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 BNIP3_CSE1L_FRAP1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2 AKT1_ATG7_TKT_HMGB1_SESN2 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_AKT1_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1 AKT1_ATG5_ATG7_TKT_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1 ATG12_ATG7_TKT_LAMP2_SESN2 ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1 CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2
七种的组合 八种的组合 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAG AKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2 ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2 ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG AIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAG ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1 ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2
ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1_UVRAG ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1 ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2 ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1 AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 ATG7_TKT_CDH1_ID2_MMP9_TCF3_SESN2 TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1
。
32.如权利要求23所述的方法，所述方法用于预测B组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表10]
一种 两种的组合 三种的组合 四种的组合 HMGB1 ATG3_HMGB1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1 TKT ATG3_BECN1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG TKT_HMGB1 ATG3_TKT_HMGB1 ATG3_BCL2_TKT_HMGB1 BCL2L1_TKT ATG3_CDH1_HMGB1 ATG3_BCL2_HMGB1_RAGE ATG3_NAMPT ATG3_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2 BCL2_HMGB1 ATG3_HMGB1_UVRAG ATG3_CDH1_HMGB1_SIRT1 HMGB1_TWIST1 ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_MMP2 ATG12_ATG3 ATG3_HMGB1_SIRT1 ATG3_HMGB1_HMGB2_RAGE CSE1L_DIABLO ATG3_BECN1_SATB1 ATG3_BCL2_BNIP3_HMGB1 ATG3_TKT ATG3_HMGB1_SATB1 ATG3_CDH1_CASP3_HMGB1 LAMP1_HMGB1 ATG3_LC3_BECN1 ATG3_CDH1_HMGB1_KIAA1967 TKT_BECN1 ATG3_HMGB1_LAMP2 ATG3_HMGB1_RAGE_UVRAG CDH1_HMGB1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_RAGE_SIRT1 HMGB1_TP63 ATG3_HMGB1_KIAA1967 ATG3_TKT_HMGB1_HMGB2 TKT_NAMPT BCL2L1_TKT_CASP3 ATG3_TKT_HMGB1_UVRAG BCL2_TKT ATG12_ATG3_HMGB1 ATG3_BCL2_LAMP1_HMGB1 CSE1L_TKT BCL2L1_TKT_SIRT1 ATG3_BCL2_HMGB1_RAPTOR LC3_TKT ATG3_CIAP2_HMGB1 AIFM1_ATG3_BCL2_HMGB1 TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_CASP3_HMGB1_RAGE FASLG_HMGB1 BCL2_TKT_HMGB1 ATG12_ATG3_HMGB1_RAGE CDH2_HMGB1 ATG3_BECN1_SESN3 ATG3_TKT_CASP3_HMGB1 ATG5_HMGB1 ATG3_CASP8_HMGB1 ATG3_TKT_HMGB1_KIAA1967 HMGB1_SIRT1 ATG3_CDH2_HMGB1 ATG3_BCL2L1_TKT_BECN1 ATG12_HMGB1 ATG3_FRAP1_HMGB1 ATG12_ATG3_CDH1_HMGB1
HMGB1_RAGE ATG3_BNIP3_HMGB1 ATG3_CDH1_HMGB1_RAGE HMGB1_UVRAG ATG3_BECN1_HMGB1 ATG3_BCL2_FRAP1_HMGB1 BCL2L1_SIRT1 ATG3_CBS_HMGB1 ATG3_BCL2_HMGB1_LAMP2 ATG3_TCF3 AIFM1_ATG3_HMGB1 ATG3_BCL2_DIABLO_HMGB1 BCL2L1_HMGB1 ATG3_HMGB1_STAT3 ATG3_TKT_HMGB1_SIRT1 TKT_SIRT1 ATG3_HMGB1_MMP2 ATG3_BCL2_CBS_HMGB1 HMGB1_LAMP2 ATG3_LAMP1_HMGB1 ATG3_BCL2_CASP8_HMGB1 TKT_SESN2 BCL2L1_TKT_FASLG ATG3_HMGB1_HMGB2_SATB1 HMGB1_MMP2 ATG3_DIABLO_HMGB1 ATG3_BCL2_PTEN_HMGB1 TKT_AGER BCL2_BCL2L1_TKT ATG3_HMGB1_RAGE_RAPTOR HMGB1_RAPTOR TKT_HMGB1_TWIST1 ATG3_TKT_HMGB1_RAGE E2F1_HMGB1 ATG3_NNMT_HMGB1 ATG3_BCL2_CASP3_HMGB1 CASP8_HMGB1 ATG3_MMP9_HMGB1 ATG3_BCL2_HMGB1_SATB1 TKT_ID2 BCL2L1_TKT_HMGB1 ATG3_HMGB1_LAMP2_RAGE AKT1_TKT ATG3_LAMP1_BECN1 ATG3_CDH1_HMGB1_LAMP2 ATG3_SIRT1 ATG3_BCL2L1_BECN1 ATG3_HMGB1_HMGB2_UVRAG TKT_RPS19BP1 ATG5_TKT_HMGB1 ATG3_BCL2L1_TKT_HMGB1 CSE1L_HMGB1 ATG3_FASLG_HMGB1 CDH1_HMGB1_TP63_UVRAG BCL2L1_BECN1 ATG3_MMP9_BECN1 ATG3_CDH1_HMGB1_HMGB2 CASP3_HMGB1 ATG3_ATG7_BECN1 ATG3_BCL2L1_TKT_CASP3 ATG7_HMGB1 ATG3_HMGB1_SESN3 ATG3_HMGB1_KIAA1967_RAGE FRAP1_HMGB1 ATG3_E2F1_HMGB1 ATG3_BCL2_DRAM_HMGB1 HMGB1_HMGB2 HMGB1_RAPTOR_TWIST1 ATG3_LC3_TKT_HMGB1 HMGB1_SATB1 AKT1_ATG3_BECN1 ATG3_BCL2_HMGB1_UVRAG ATG3_ULK1 ATG3_FAS_HMGB1 ATG3_CDH1_CDH2_HMGB1 ATG3_SESN1 ATG3_ULK1_HMGB1 BCL2_BCL2L1_TKT_CASP3 CBS_HMGB1 TKT_HMGB1_SIRT1 ATG3_TKT_BECN1_HMGB1 TKT_KIAA1967 ATG3_BAX_HMGB1 ATG3_TKT_HMGB1_LAMP2 ATG12_BCL2L1 TKT_CDH2_HMGB1 ATG3_BCL2_PRKAA1_HMGB1 DRAM_HMGB1 ATG3_PTEN_HMGB1 BCL2L1_TKT_CASP3_SIRT1 LC3_FASLG ATG3_TKT_BECN1 BCL2L1_TKT_CASP3_FASLG HMGB1_KIAA1967 ATG3_HMGB1_TWIST1 BCL2L1_TKT_CASP3_CDH2 TKT_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2_NNMT_HMGB1
五种的组合 六种的组合 ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2 ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967 ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2 ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967
ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1 ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1 ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1 ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3 ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1 ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1 ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE
AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1 ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG
。
33.如权利要求23所述的方法，所述方法用于预测B组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表11]
一种 两种的组合 三种的组合 四种的组合 ATG12 DIABLO_NAMPT DIABLO_ID2_NAMPT ATG12_ID2_MMP9_TCF3 DIABLO ATG12_ID2 DIABLO_FAS_NAMPT DIABLO_FAS_ID2_NAMPT UVRAG ATG12_RPS19BP1 ATG12_ID2_TCF3 ATG12_CSE1L_ID2_MMP9 NAMPT ATG12_DIABLO DIABLO_FAS_STAT3 DIABLO_ID2_MMP9_NAMPT STAT3 ID2_NAMPT ATG12_ID2_MMP9 DIABLO_FAS_MMP9_NAMPT E2F1 DIABLO_STAT3 ATG12_ID2_SATB1 DIABLO_ID2_NAMPT_STAT3 BECN1 DIABLO_FAS ATG12_ID2_RPS19BP1 ATG12_FAS_ID2_MMP9 FRAP1 ATG12_CSE1L ATG12_CSE1L_ID2 ATG12_ID2_MMP9_SATB1 ATG7 ATG12_MMP9 ATG12_DIABLO_FAS DIABLO_ID2_NAMPT_SATB1 ID2 ATG12_ATG3 ATG12_ID2_SESN2 ATG12_ID2_MMP9_SESN2 SIRT1 ATG12_SATB1 ATG12_ID2_NAMPT ATG12_ID2_MMP9_RPS19BP1 BCL2 ATG12_SESN2 ATG12_CSE1L_DIABLO CSE1L_DIABLO_ID2_NAMPT BNIP3 CSE1L_DIABLO ID2_NAMPT_STAT3 DIABLO_ID2_TCF3_NAMPT LAMP2 ATG12_TCF3 ATG12_ID2_BHLHE41 DIABLO_FAS_NAMPT_SATB1 TKT ATG12_FAS CSE1L_DIABLO_NAMPT ATG12_DIABLO_FAS_MMP9 ATG12_STAT3 DIABLO_LC3_NAMPT DIABLO_FAS_ID2_STAT3 ATG12_BHLHE41 ATG12_FAS_ID2 ATG12_ATG3_ID2_TCF3 ATG12_NAMPT ID2_NAMPT_RPS19BP1 ATG3_DIABLO_ID2_NAMPT ATG12_ATG7 ID2_MMP9_TCF3 ATG12_ID2_TCF3_STAT3 ID2_BECN1 DIABLO_NAMPT_SATB1 DIABLO_FAS_NAMPT_STAT3 E2F1_FAS ATG12_CSE1L_MMP9 ATG12_CSE1L_DIABLO_MMP9
ATG12_ATG5 ATG12_MMP9_RPS19BP1 ATG12_ID2_TCF3_SATB1 ID2_STAT3 ID2_MMP9_BECN1 DIABLO_FAS_MMP9_STAT3 ATG12_ULK1 DIABLO_NAMPT_STAT3 ATG12_ID2_MMP9_BHLHE41 DIABLO_BECN1 ATG12_DIABLO_MMP9 ATG12_BNIP3_ID2_MMP9 ATG12_LAMP1 ATG12_FAS_RPS19BP1 DIABLO_FAS_SATB1_STAT3 ATG12_LC3 DIABLO_FAS_MMP9 DIABLO_FAS_NAMPT_RPS19BP1 DIABLO_TCF3 ID2_MMP9_NAMPT ATG12_ATG3_ID2_MMP9 AKT1_ATG12 ATG12_ID2_STAT3 ATG12_ID2_MMP9_NAMPT ATG12_FRAP1 ATG12_DIABLO_TCF3 DIABLO_FAS_NAMPT_SESN2 DIABLO_ID2 ATG12_ATG3_ID2 DIABLO_ID2_NAMPT_SESN2 ID2_TCF3 ATG12_DIABLO_ID2 ATG12_ID2_TCF3_RPS19BP1 DIABLO_SATB1 CSE1L_DIABLO_STAT3 ATG12_DIABLO_MMP9_TCF3 ATG12_BECN1 DIABLO_ID2_STAT3 ATG12_CSE1L_ID2_SATB1 ATG12_SIRT1 ATG12_ATG3_RPS19BP1 ATG12_FAS_MMP9_RPS19BP1 NAMPT_STAT3 ATG12_DIABLO_SATB1 ID2_MMP9_TCF3_STAT3 ATG12_BNIP3 ATG12_MMP9_TCF3 ATG12_DIABLO_ID2_NAMPT DIABLO_MMP9 ATG3_DIABLO_NAMPT DIABLO_ID2_TCF3_STAT3 ATG12_UVRAG ATG12_DIABLO_NAMPT ATG12_ULK1_ID2_TCF3 DIABLO_FRAP1 ATG12_CSE1L_RPS19BP1 ATG12_ID2_TCF3_SESN2 NAMPT_RPS19BP1 DIABLO_MMP9_NAMPT BNIP3_CSE1L_DIABLO_MMP9 AKT1_NAMPT ATG12_ATG3_DIABLO ATG12_DIABLO_ID2_TCF3 E2F1_UVRAG DIABLO_SATB1_STAT3 ATG12_ATG5_ID2_MMP9 ATG3_DIABLO ID2_TCF3_STAT3 ATG12_ID2_SATB1_STAT3 NAMPT_UVRAG ATG12_RPS19BP1_SATB1 ATG12_MMP9_TCF3_RPS19BP1 BNIP3_DIABLO ATG12_DIABLO_STAT3 ATG12_DIABLO_FAS_ID2 DIABLO_LC3 ATG12_TCF3_RPS19BP1 ATG12_CSE1L_ID2_SESN2 DIABLO_SIRT1 DIABLO_NAMPT_SESN2 DIABLO_FAS_MMP9_TCF3 LC3_NAMPT ATG12_DIABLO_SESN2 ATG12_ID2_TCF3_BHLHE41 DIABLO_SESN2 ATG12_ULK1_ID2 ATG12_FAS_ID2_STAT3 FAS_STAT3 ATG12_ATG5_ID2 BNIP3_CSE1L_ID2_MMP9 FAS_NAMPT AKT1_DIABLO_NAMPT CSE1L_DIABLO_FAS_NAMPT E2F1_NAMPT ATG12_ID2_BECN1 ATG12_CSE1L_ID2_TCF3 ATG12_SESN3 ATG12_FAS_MMP9 ATG12_ID2_NAMPT_RPS19BP1 BCL2_TKT ATG12_DIABLO_BHLHE41 ATG12_ID2_MMP9_BECN1 ATG7_NAMPT ATG12_RPS19BP1_STAT3 DIABLO_FAS_LC3_NAMPT ATG7_BECN1 DIABLO_NAMPT_RPS19BP1 FAS_ID2_NAMPT_RPS19BP1 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 DIABLO_FAS_ID2_MMP9_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3 ATG12_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_CSE1L_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3 ATG12_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_FAS_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ID2_MMP9_TCF3 DIABLO_FAS_ID2_NAMPT_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_SESN2 ATG12_ID2_MMP9_TCF3_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3 ATG12_BNIP3_ID2_MMP9_RPS19BP1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT ATG12_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3 ATG12_CSE1L_ID2_MMP9_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2 DIABLO_FAS_ID2_NAMPT_SATB1 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1 DIABLO_ID2_MMP9_TCF3_NAMPT DIABLO_FAS_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9 ATG12_ID2_MMP9_TCF3_BHLHE41 ATG12_ATG3_BNIP3_ID2_MMP9_SATB1 ATG12_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9
ATG12_BNIP3_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SATB1 CSE1L_DIABLO_ID2_MMP9_NAMPT ATG12_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_DIABLO_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1 DIABLO_ID2_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_NAMPT_SATB1_STAT3 ATG12_ATG3_CSE1L_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_DIABLO_FAS_ID2_MMP9 ATG12_CSE1L_ID2_MMP9_TCF3_SESN2 DIABLO_FAS_ID2_MMP9_STAT3 ATG12_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_CSE1L_ID2_MMP9_BHLHE41 ATG12_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_ID2_MMP9_NAMPT_STAT3 ATG12_ATG3_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_NAMPT_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9 ATG12_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_TCF3_NAMPT ATG12_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_SATB1 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_ID2_MMP9_BHLHE41 ATG12_DIABLO_FAS_ID2_MMP9_TCF3 ATG3_DIABLO_FAS_ID2_NAMPT ATG12_ULK1_ID2_MMP9_TCF3_SESN2 CSE1L_DIABLO_FAS_ID2_NAMPT ATG3_DIABLO_FAS_ID2_MMP9_NAMPT ATG12_CSE1L_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_ID2_MMP9_SESN2 ATG12_CSE1L_ULK1_ID2_MMP9 ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41 DIABLO_FAS_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9 CSE1L_DIABLO_ID2_NAMPT_STAT3 DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1 DIABLO_ID2_MMP9_TCF3_STAT3 ATG12_ATG5_ID2_MMP9_TCF3_SATB1 DIABLO_ID2_TCF3_NAMPT_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3 CSE1L_DIABLO_FAS_MMP9_NAMPT ATG12_ATG3_CSE1L_ID2_MMP9_SATB1 DIABLO_FAS_ID2_NAMPT_RPS19BP1 ATG12_ATG3_ID2_MMP9_TCF3_STAT3 BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_ID2_MMP9_SATB1 DIABLO_ID2_MMP9_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_DIABLO_FAS_MMP9_TCF3 ATG12_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG5_FAS_ID2_MMP9 DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_LC3_ID2_MMP9_TCF3 ATG12_ATG3_CSE1L_ID2_MMP9_SESN2 ATG12_FAS_ID2_MMP9_STAT3 ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1 FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_ATG5_BNIP3_FAS_ID2_MMP9 ATG12_ID2_MMP9_TCF3_BECN1 ATG12_ATG5_ULK1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3 E2F1_FAS_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3 ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2
DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3 ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2 ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1 ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2 ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1 ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2 ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1 ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2 ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1 ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2 ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3 ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3 DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9 CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41 DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3 CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_FAS_ID2_MMP9_SATB1 ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2 ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG
。
34.如权利要求23所述的方法，所述方法用于预测B组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表12]
一种 两种的组合 三种的组合 四种的组合 DIABLO ATG3_BECN1 ATG3_BCL2_HMGB1 ATG3_BCL2_CDH1_HMGB1 BECN1 ATG3_HMGB1 ATG3_HMGB1_RAGE ATG3_CDH1_HMGB1_UVRAG HMGB1 BCL2L1_TKT ATG3_HMGB1_UVRAG ATG3_BCL2_TKT_HMGB1 CSE1L_DIABLO ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_RAGE BCL2_HMGB1 ATG3_HMGB1_SIRT1 ATG3_BCL2_HMGB1_HMGB2 ATG12_ATG3 ATG3_BECN1_SATB1 ATG3_CDH1_HMGB1_SIRT1 ATG3_NAMPT ATG3_HMGB1_LAMP2 ATG3_BCL2_HMGB1_MMP2 HMGB1_TWIST1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_HMGB2_RAGE TKT_HMGB1 ATG3_LC3_BECN1 ATG3_BCL2_BNIP3_HMGB1 LAMP1_HMGB1 ATG3_HMGB1_KIAA1967 ATG3_CDH1_CASP3_HMGB1 TKT_BECN1 BCL2L1_TKT_CASP3 ATG3_CDH1_HMGB1_KIAA1967 HMGB1_TP63 ATG12_ATG3_HMGB1 ATG3_HMGB1_RAGE_UVRAG BCL2_TKT BCL2L1_TKT_SIRT1 ATG3_HMGB1_RAGE_SIRT1 TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_TKT_HMGB1_UVRAG FASLG_HMGB1 BCL2_TKT_HMGB1 ATG3_BCL2_LAMP1_HMGB1 TKT_NAMPT ATG3_BECN1_SESN3 ATG3_BCL2_HMGB1_RAPTOR ATG5_HMGB1 ATG3_BNIP3_HMGB1 AIFM1_ATG3_BCL2_HMGB1
HMGB1_SIRT1 ATG3_BECN1_HMGB1 ATG3_CASP3_HMGB1_RAGE ATG12_HMGB1 AIFM1_ATG3_HMGB1 ATG12_ATG3_HMGB1_RAGE HMGB1_RAGE ATG3_LAMP1_HMGB1 ATG3_TKT_CASP3_HMGB1 DIABLO_NAMPT BCL2L1_TKT_FASLG ATG3_TKT_HMGB1_KIAA1967 HMGB1_UVRAG BCL2_BCL2L1_TKT ATG3_BCL2L1_TKT_BECN1 DIABLO_BECN1 TKT_HMGB1_TWIST1 ATG12_ATG3_CDH1_HMGB1 BECN1_SATB1 ATG3_NNMT_HMGB1 ATG3_CDH1_HMGB1_RAGE BCL2L1_SIRT1 BCL2L1_TKT_HMGB1 ATG3_BCL2_FRAP1_HMGB1 BCL2L1_HMGB1 ATG3_BCL2L1_BECN1 ATG3_BCL2_HMGB1_LAMP2 TKT_SIRT1 ATG5_TKT_HMGB1 ATG3_BCL2_DIABLO_HMGB1 DIABLO_TCF3 ATG3_FASLG_HMGB1 ATG3_TKT_HMGB1_SIRT1 HMGB1_LAMP2 ATG3_MMP9_BECN1 ATG3_BCL2_CBS_HMGB1 DIABLO_SATB1 ATG3_LAMP1_BECN1 ATG3_BCL2_CASP8_HMGB1 HMGB1_RAPTOR ATG3_E2F1_HMGB1 ATG3_BCL2_PTEN_HMGB1 E2F1_HMGB1 HMGB1_RAPTOR_TWIST1 ATG3_HMGB1_RAGE_RAPTOR ATG5_BECN1 AKT1_ATG3_BECN1 ATG3_TKT_HMGB1_RAGE ATG12_SATB1 ATG3_ULK1_HMGB1 ATG3_BCL2_CASP3_HMGB1 BCL2L1_BECN1 TKT_HMGB1_SIRT1 ATG3_BCL2_HMGB1_SATB1 CASP3_HMGB1 ATG3_BAX_HMGB1 ATG3_HMGB1_LAMP2_RAGE ATG12_CSE1L ATG3_PTEN_HMGB1 ATG3_CDH1_HMGB1_LAMP2 ATG7_HMGB1 ATG3_TKT_HMGB1 ATG3_HMGB1_HMGB2_UVRAG ATG3_SIRT1 ATG3_TKT_BECN1 ATG3_BCL2L1_TKT_HMGB1 CASP8_HMGB1 ATG3_HMGB1_TWIST1 CDH1_HMGB1_TP63_UVRAG ATG3_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2L1_TKT_CASP3 TKT_KIAA1967 TKT_HMGB1_UVRAG ATG3_HMGB1_KIAA1967_RAGE ATG12_BCL2L1 BCL2L1_TKT_CDH2 ATG3_BCL2_DRAM_HMGB1 DRAM_HMGB1 BCL2L1_TKT_KIAA1967 ATG3_BCL2_HMGB1_UVRAG LC3_FASLG ATG3_BCL2L1_HMGB1 BCL2_BCL2L1_TKT_CASP3 HMGB1_KIAA1967 ATG3_ATG5_HMGB1 ATG3_TKT_BECN1_HMGB1 TKT_SESN1 ATG3_DRAM_HMGB1 ATG3_TKT_HMGB1_LAMP2 ATG3_DIABLO ATG3_HMGB1_SATB1 ATG3_BCL2_PRKAA1_HMGB1 DIABLO_SIRT1 ATG3_BCL2L1_TKT BCL2L1_TKT_CASP3_SIRT1 BECN1_HMGB1 ATG3_PRKAA1_HMGB1 BCL2L1_TKT_CASP3_FASLG AIFM1_HMGB1 TKT_CASP3_HMGB1 BCL2L1_TKT_CASP3_CDH2 ID2_BECN1 ATG3_XIAP_HMGB1 ATG3_BCL2_NNMT_HMGB1 CSE1L_BECN1 TKT_HMGB1_KIAA1967 ATG3_CDH1_HMGB1_RAPTOR TKT_ULK1 TKT_HMGB1_LAMP2 ATG3_BNIP3_HMGB1_RAGE BNIP3_HMGB1 HMGB1_RAGE_TWIST1 ATG3_BAX_BCL2_HMGB1 TKT_UVRAG ATG12_BCL2L1_TKT ATG3_BCL2_ID2_HMGB1 ATG5_TKT ATG3_PTEN_BECN1 ATG3_BCL2_HMGB1_STAT3
五种的组合 六种的组合 ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG ATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2 ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967
ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR ATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2 ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967 ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE ATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1 ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG ATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1 ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG ATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1 ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR AIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGE ATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG ATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG ATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR ATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3 ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG ATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1 ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1 ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG ATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG CDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3
七种的组合 八种的组合 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE
ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAG ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967 AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1 ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967 AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAG ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAG ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE NNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG
。
35.如权利要求23所述的方法，所述方法用于预测C组的复发预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表13]
一种 两种的组合 三种的组合 四种的组合 FASLG CIAP2_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG CIAP2 E2F1_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG CSE1L LC3_FASLG E2F1_LC3_FASLG BNIP3_FAS_LC3_FASLG FAS DIABLO_FASLG FAS_FASLG_RPS19BP1 DRAM_FAS_LC3_FASLG TCF3 FAS_FASLG E2F1_FAS_FASLG E2F1_FAS_LC3_FASLG FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG3_FAS_LC3_FASLG PTEN_FASLG DIABLO_LC3_FASLG ATG7_FAS_LC3_FASLG CASP3_FASLG ATG7_FAS_FASLG FAS_LC3_FASLG_STAT3 FASLG_SESN2 CIAP2_FASLG_SESN3 FAS_FRAP1_LC3_FASLG FASLG_HMGB1 CIAP2_FASLG_UVRAG FAS_LC3_FASLG_SESN3 CDH2_FASLG BNIP3_LC3_FASLG FAS_LC3_FASLG_SIRT1 FRAP1_FASLG LC3_CIAP2_FASLG FAS_LC3_BECN1_FASLG ATG7_FASLG LC3_FASLG_SESN2 ATG5_FAS_LC3_FASLG ATG3_FAS FRAP1_LC3_FASLG FAS_LC3_FASLG_RPS19BP1
FASLG_HMGB2 LC3_FASLG_SESN3 FAS_LAMP1_LC3_FASLG FASLG_UVRAG ATG3_FAS_FASLG FAS_LC3_FASLG_NAMPT DIABLO_FAS ATG7_LC3_FASLG AKT1_FAS_LC3_FASLG FASLG_MMP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_SESN2 TKT_FASLG DIABLO_FASLG_SESN2 FAS_LC3_MMP9_FASLG PTEN_CIAP2 DRAM_LC3_FASLG FAS_FASLG_RPS19BP1_SESN3 FAS_LC3 CIAP2_FASLG_HMGB1 FAS_FASLG_RPS19BP1_UVRAG CBS_FASLG FAS_FASLG_SESN3 FAS_LC3_CDH1_FASLG AIFM1_FASLG LC3_FASLG_UVRAG ATG12_FAS_LC3_FASLG CASP3_CIAP2 CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_SESN3 FASLG_SESN3 FAS_FASLG_SESN2 DIABLO_FAS_FASLG_UVRAG ATG3_FASLG PTEN_CIAP2_FASLG FAS_LC3_FASLG_LAMP2 CASP8_FASLG DIABLO_FASLG_SESN3 FAS_LC3_ID2_FASLG XIAP_FASLG ATG7_CIAP2_FASLG DIABLO_FAS_FASLG_SESN2 AGER_FASLG LC3_FASLG_SIRT1 FAS_LC3_BHLHE41_FASLG ATG3_ULK1 LC3_FASLG_RPS19BP1 DIABLO_DRAM_FAS_FASLG BNIP3_FASLG FASLG_SESN2_SESN3 DIABLO_FAS_FASLG_STAT3 FAS_UVRAG DRAM_FAS_FASLG DRAM_FAS_FASLG_RPS19BP1 CIAP2_RAGE ID2_CIAP2_FASLG DIABLO_FAS_FRAP1_FASLG ATG3_TCF3 FAS_FASLG_STAT3 FAS_FASLG_SESN2_UVRAG FASLG_RAGE AKT1_CIAP2_FASLG ATG3_FAS_FASLG_SESN2 E2F1_CIAP2 DIABLO_FRAP1_FASLG ATG7_DIABLO_FAS_FASLG FASLG_VEGF BNIP3_FAS_FASLG FAS_LC3_TCF3_FASLG E2F1_FAS FAS_LAMP1_FASLG ATG7_FAS_FASLG_UVRAG XIAP_CIAP2 TKT_CIAP2_FASLG DIABLO_FAS_FASLG_NAMPT BCL2L1_FASLG ATG7_DIABLO_FASLG DIABLO_FAS_FASLG_SIRT1 BNIP3_FAS FRAP1_FASLG_SESN2 DIABLO_FAS_LAMP1_FASLG FASLG_SESN1 E2F1_ULK1_FASLG FAS_FRAP1_FASLG_RPS19BP1 FASLG_KIAA1967 DRAM_CIAP2_FASLG CSE1L_FAS_LC3_FASLG AIFM1_CIAP2 PTEN_CASP3_FASLG DIABLO_FAS_BECN1_FASLG DRAM_FASLG LC3_FASLG_NAMPT E2F1_LC3_ID2_FASLG ATG3_CIAP2 PTEN_CDH1_CIAP2 AKT1_DIABLO_FAS_FASLG CSE1L_FASLG ATG12_CIAP2_FASLG ATG3_DIABLO_FAS_FASLG FASLG_RAPTOR FASLG_RPS19BP1_SESN3 E2F1_FAS_FASLG_SESN3 TCF3_FASLG MMP9_CIAP2_FASLG ATG7_FAS_FASLG_SESN2 FASLG_STAT3 LAMP1_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1 ULK1_FASLG LC3_BECN1_FASLG DRAM_FAS_FASLG_UVRAG PRKAA1_CIAP2 CDH1_CIAP2_FASLG LC3_MMP9_FASLG_SESN2 FASLG_SIRT1 BECN1_CIAP2_FASLG FAS_FASLG_SESN3_UVRAG ATG12_FASLG CIAP2_FASLG_HMGB2 DIABLO_FAS_FASLG_LAMP2 LAMP1_FASLG E2F1_FASLG_LAMP2 DIABLO_FAS_ID2_FASLG NNMT_FASLG CIAP2_FASLG_SIRT1 E2F1_LC3_FASLG_LAMP2 BCL2L1_CIAP2 PTEN_XIAP_FASLG E2F1_LC3_MMP9_FASLG CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 BNIP3_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2 DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN3 DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SIRT1 DIABLO_FAS_LC3_BECN1_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DIABLO_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_BECN1_FASLG ATG7_DRAM_FAS_LC3_FASLG DRAM_FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_SIRT1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG
DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BECN1_FASLG DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN3 DIABLO_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN3 DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2 ATG5_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG ATG5_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_FASLG_SESN3_SIRT1 FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BHLHE41_FASLG_UVRAG DRAM_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2 DIABLO_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_DRAM_FAS_LC3_FASLG FAS_LC3_BECN1_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG ATG3_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN3_SIRT1 BNIP3_FAS_LC3_FASLG_SIRT1 ATG3_DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_FRAP1_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN3_STAT3 DIABLO_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_BECN1_FASLG_SESN2 DIABLO_FAS_LC3_FASLG_NAMPT BNIP3_FAS_LC3_FASLG_SESN2_SIRT1 FAS_LC3_MMP9_FASLG_RPS19BP1 DIABLO_DRAM_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_BECN1_FASLG BNIP3_FAS_LC3_BECN1_FASLG_SESN3 E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG ATG3_FAS_FRAP1_LC3_MMP9_FASLG DIABLO_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_BECN1_FASLG_SESN3 FAS_LC3_ID2_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BECN1_FASLG DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_DRAM_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG DRAM_FAS_LAMP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG ATG3_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG FAS_LC3_FASLG_STAT3_UVRAG ATG5_DRAM_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_STAT3 FAS_LC3_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_FASLG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG AKT1_DRAM_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_SESN2 FAS_LC3_FASLG_SESN2_UVRAG ATG5_FAS_LC3_MMP9_FASLG_UVRAG FAS_LC3_BHLHE41_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_FASLG_NAMPT DIABLO_DRAM_FAS_LC3_FASLG_STAT3 FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG_SESN3 ATG7_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_TCF3_FASLG_UVRAG AKT1_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1 E2F1_FAS_LC3_ID2_FASLG ATG5_DRAM_FAS_LC3_FASLG_STAT3 DRAM_FAS_LC3_CDH1_FASLG ATG7_DRAM_FAS_LC3_MMP9_FASLG PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合 八种的组合 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3
BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3 ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3 ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1 BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2 ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN3 BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG BNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3 ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1 FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG
。
36.如权利要求23所述的方法，所述方法用于预测C组的存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表14]
一种 两种的组合 三种的组合 四种的组合 CSE1L ID2_CIAP2 ID2_CIAP2_SESN2 AIFM1_ID2_CIAP2_SESN2 CIAP2 CASP3_CIAP2 ID2_CASP3_CIAP2 PTEN_ID2_CIAP2_SESN2 TCF3 ID2_TCF3 ULK1_ID2_HMGB2 DIABLO_ID2_CASP3_CIAP2 CDH2 DIABLO_CDH2 ULK1_ID2_HMGB1 DRAM_FRAP1_CIAP2_TP63 FASLG CSE1L_CDH2 DIABLO_ID2_CASP3 BAX_ID2_CIAP2_SESN2 BECN1 CSE1L_TCF3 ULK1_ID2_AGER ID2_CIAP2_SESN2_VEGF CASP3 CSE1L_CASP3 ID2_CIAP2_RPS19BP1 DRAM_ID2_CIAP2_SESN2 CDH1 CSE1L_RPS19BP1 CASP8_ULK1_ID2 ID2_CIAP2_RPS19BP1_SESN2 CDH2_CIAP2 ID2_TCF3_CIAP2 CBS_ID2_CIAP2_SESN2 ULK1_ID2 FRAP1_ID2_CIAP2 ATG3_ID2_CIAP2_SESN2
CSE1L_ID2 AIFM1_CDH1_CIAP2 NNMT_ID2_CIAP2_SESN2 CDH1_CIAP2 PTEN_CDH1_CIAP2 DIABLO_ID2_CIAP2_SESN2 CSE1L_FASLG ULK1_ID2_CIAP2 PRKAA1_ID2_CIAP2_SESN2 NNMT_CIAP2 DIABLO_ID2_CDH2 FRAP1_ID2_CIAP2_SESN2 CSE1L_MMP9 CDH1_CIAP2_VEGF DIABLO_DRAM_ID2_CASP3 CSE1L_CDH1 CDH1_CCNG2_CIAP2 XIAP_ID2_CIAP2_SESN2 CIAP2_RPS19BP1 BAX_CDH1_CIAP2 ID2_CIAP2_RAGE_SESN2 ID2_CDH2 ATG3_ID2_TCF3 DRAM_CIAP2_SESN2_TP63 CDH2_RPS19BP1 ULK1_ID2_MMP2 BNIP3_ID2_CIAP2_SESN2 CSE1L_STAT3 CBS_ULK1_ID2 BCL2L1_ID2_CIAP2_SESN2 DIABLO_CASP3 DIABLO_ID2_CIAP2 AIFM1_DIABLO_CDH1_CIAP2 CDH1_TCF3 LC3_ID2_CIAP2 ID2_CCNG2_CIAP2_SESN2 CSE1L_SIRT1 PTEN_ULK1_ID2 LC3_ID2_CIAP2_SESN2 CIAP2_SESN2 BAX_ULK1_ID2 ID2_CASP3_CIAP2_RPS19BP1 AIFM1_CIAP2 DIABLO_PTEN_CDH1 AIFM1_CDH1_CIAP2_SESN2 DIABLO_KIAA1967 CDH1_CASP3_CIAP2 ATG3_ID2_TCF3_RPS19BP1 CSE1L_KIAA1967 ULK1_ID2_CDH2 DIABLO_FRAP1_ID2_CDH2 AKT1_CSE1L CDH1_CIAP2_RAGE E2F1_ID2_CIAP2_SESN2 CSE1L_SESN2 ID2_CDH2_CIAP2 ID2_CASP3_CIAP2_SESN2 FRAP1_CDH2 NNMT_ID2_CIAP2 DRAM_ID2_CIAP2_RPS19BP1 FRAP1_CIAP2 XIAP_CIAP2_SESN2 ID2_CIAP2_HMGB1_SESN2 TCF3_FASLG CSE1L_ID2_CASP3 PTEN_ID2_CASP3_CIAP2 FASLG_SESN2 CSE1L_FRAP1_CDH2 ATG3_ID2_MMP9_TCF3 CSE1L_DIABLO BCL2_ID2_SESN2 LAMP1_ID2_CIAP2_SESN2 CSE1L_SATB1 AIFM1_ULK1_ID2 AIFM1_ID2_CASP3_CIAP2 MMP9_TCF3 ULK1_ID2_RAGE ATG5_ID2_CIAP2_SESN2 ATG12_CSE1L DIABLO_CDH1_CCNG2 DIABLO_PTEN_CDH1_CIAP2 ATG7_CSE1L BAX_DIABLO_CDH1 LAMP1_ID2_CASP3_CIAP2 CSE1L_BECN1 CSE1L_ID2_CDH2 ID2_CIAP2_HMGB2_SESN2 XIAP_CIAP2 AIFM1_CIAP2_SESN2 BCL2L1_CSE1L_ID2_SESN2 CSE1L_FAS NNMT_CDH1_CIAP2 TKT_ID2_CIAP2_SESN2 TCF3_RPS19BP1 CBS_ID2_CIAP2 DIABLO_XIAP_ID2_SESN2 XIAP_SESN2 DIABLO_CDH1_VEGF FRAP1_LC3_ID2_CIAP2 CIAP2_KIAA1967 ID2_MMP9_TCF3 ATG7_ID2_CIAP2_SESN2 TKT_CIAP2 AIFM1_DIABLO_CDH1 ID2_AGER_CIAP2_SESN2 PRKAA1_CIAP2 PRKAA1_CIAP2_SESN2 CSE1L_ID2_CASP3_CIAP2 CDH2_FASLG CDH1_ID2_CIAP2 DRAM_CASP3_CIAP2_TP63 CSE1L_FRAP1 CSE1L_CASP3_CIAP2 PTEN_CDH1_ID2_CIAP2 CSE1L_CIAP2 ULK1_ID2_VEGF CDH1_ID2_CIAP2_RPS19BP1 CSE1L_ULK1 ID2_CIAP2_HMGB1 ATG3_ULK1_ID2_HMGB1 PTEN_CIAP2 BCL2L1_CDH1_CIAP2 FRAP1_ID2_CIAP2_RPS19BP1 BCL2L1_CIAP2 ID2_CIAP2_MMP2 DIABLO_PTEN_ID2_CASP3 CIAP2_VEGF CSE1L_ID2_CIAP2 ID2_CIAP2_SESN2_TP63 ATG3_TCF3 BCL2L1_CSE1L_CDH1 ID2_TCF3_CIAP2_SESN2 AKT1_TCF3 CSE1L_CDH1_CASP3 DIABLO_CDH1_CIAP2_VEGF CSE1L_LC3 CSE1L_XIAP_SESN2 ATG3_ULK1_ID2_AGER TKT CDH2 PRKAA1_CDH1_CIAP2 ID2_CIAP2_MMP2_SESN2 CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63 DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_DRAM_FRAP1_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_FRAP1_XIAP_CIAP2_TP63 DRAM_TKT_ID2_CIAP2_SESN2_TP63 DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_CDH1_CIAP2_TP63 AIFM1_DRAM_FRAP1_CIAP2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_PTEN_ID2_CIAP2_SESN2_TP63 PTEN_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 BAX_CDH1_ID2_CIAP2_SESN2 DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63
DRAM_FRAP1_ID2_CIAP2_TP63 ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63 DRAM_TKT_CASP3_CIAP2_TP63 ATG7_DRAM_ID2_CIAP2_SESN2_TP63 CDH1_ID2_CCNG2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_PTEN_ID2_CIAP2_SESN2 ATG5_DRAM_ID2_CIAP2_SESN2_TP63 DIABLO_FRAP1_CDH1_ID2_CIAP2 AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2 AIFM1_CBS_ID2_CIAP2_SESN2 AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63 AIFM1_LAMP1_ID2_CIAP2_SESN2 BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_ID2_CASP3_CIAP2_TP63 DRAM_NNMT_ID2_CIAP2_SESN2_TP63 DIABLO_PTEN_CDH1_ID2_CIAP2 CASP8_DRAM_ID2_CIAP2_SESN2_TP63 CDH1_ID2_CIAP2_SESN2_VEGF DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63 DIABLO_CDH1_ID2_CASP3_CIAP2 DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63 AIFM1_ATG3_ID2_CIAP2_SESN2 DRAM_LAMP1_ID2_CIAP2_SESN2_TP63 AIFM1_BNIP3_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 AIFM1_DIABLO_CDH1_ID2_CIAP2 BNIP3_DRAM_ID2_CIAP2_SESN2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2 DRAM_ID2_MMP9_CIAP2_SESN2_TP63 AIFM1_BAX_ID2_CIAP2_SESN2 AKT1_DRAM_ID2_CIAP2_SESN2_TP63 DRAM_E2F1_CASP3_CIAP2_TP63 DRAM_ID2_CIAP2_RAGE_SESN2_TP63 AIFM1_ID2_CIAP2_HMGB2_SESN2 ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63 AIFM1_ID2_MMP9_CIAP2_SESN2 DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63 DIABLO_CDH1_ID2_CIAP2_VEGF DRAM_XIAP_ID2_CIAP2_SESN2_TP63 DIABLO_DRAM_XIAP_ID2_SESN2 AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63 AIFM1_ATG5_ID2_CIAP2_SESN2 ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63 AIFM1_ID2_CIAP2_HMGB1_SESN2 CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63 BAX_DIABLO_CDH1_ID2_CIAP2 AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63 DRAM_FRAP1_NNMT_CIAP2_TP63 AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63 FRAP1_CDH1_ID2_CIAP2_RPS19BP1 BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_XIAP_CIAP2_SESN2_TP63 CBS_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2 AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63 AIFM1_ID2_CIAP2_SESN2_VEGF DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63 AIFM1_TKT_ID2_CIAP2_SESN2 DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2 ATG3_ID2_MMP9_TCF3_RPS19BP1 DRAM_ID2_CIAP2_SESN2_TP63_VEGF ATG5_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63 CBS_FRAP1_ID2_CIAP2_SESN2 BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_DIABLO_ID2_CASP3_CIAP2 AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63 AIFM1_NNMT_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63 ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63 ATG3_FRAP1_ID2_CIAP2_SESN2 AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63 BAX_DIABLO_DRAM_ID2_CASP3 AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63 LAMP1_PTEN_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63 CDH1_ID2_CIAP2_RAGE_SESN2 AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63 CBS_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_CIAP2_TP63_VEGF DIABLO_CDH1_ID2_CCNG2_CIAP2 AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63 DIABLO_LAMP1_ID2_CASP3_CIAP2 DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2 AIFM1_DRAM_CASP3_CIAP2_TP63 DRAM_TKT_XIAP_CIAP2_SESN2_TP63 BCL2L1_DRAM_FRAP1_CIAP2_TP63 AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63 CDH1_ID2_MMP9_TCF3_CIAP2 BAX_CDH1_ID2_MMP9_TCF3_CIAP2
七种的组合 八种的组合 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63
AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63 AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63 ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63 AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGF AIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGF DRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63 AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63 AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF DRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 AIFM1_ATG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_DRAM_NNMT_PTEN_ID2_C_IAP2_SESN2_TP63 AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63 ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63 AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF AIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63 BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63 CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER
。
37.如权利要求23所述的方法，所述方法用于预测C组的无病存活预后，其中，所述基因是选自下表所示的基因或基因的组中的一种或多种：
[表15]
一种 两种的组合 三种的组合 四种的组合 FASLG FAS_FASLG FAS_LC3_FASLG DIABLO_FAS_LC3_FASLG CIAP2 LC3_FASLG DIABLO_FAS_FASLG FAS_LC3_FASLG_UVRAG FAS E2F1_FASLG E2F1_LC3_FASLG E2F1_FAS_LC3_FASLG CSE1L CIAP2_FASLG FAS_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG TCF3 DIABLO_FASLG E2F1_FAS_FASLG DRAM_FAS_LC3_FASLG FASLG_RPS19BP1 FAS_FASLG_UVRAG ATG7_FAS_LC3_FASLG
FASLG_SESN2 DIABLO_LC3_FASLG FAS_LAMP1_LC3_FASLG CASP3_FASLG ATG7_FAS_FASLG FAS_FRAP1_LC3_FASLG FASLG_UVRAG FAS_FASLG_SESN2 ATG3_FAS_LC3_FASLG FRAP1_FASLG LC3_FASLG_SESN2 FAS_LC3_FASLG_RPS19BP1 PTEN_FASLG FAS_LAMP1_FASLG FAS_LC3_FASLG_SESN3 FASLG_HMGB1 ATG3_FAS_FASLG FAS_LC3_FASLG_SESN2 ATG3_FAS CIAP2_FASLG_SESN3 ATG5_FAS_LC3_FASLG CASP3_CIAP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_STAT3 TCF3_FASLG FRAP1_LC3_FASLG FAS_LC3_FASLG_SIRT1 ATG7_FASLG BNIP3_LC3_FASLG AKT1_FAS_LC3_FASLG PTEN_CIAP2 FAS_FASLG_SESN3 FAS_LC3_ID2_FASLG CDH2_FASLG BNIP3_FAS_FASLG FAS_LC3_FASLG_NAMPT FASLG_SESN3 DIABLO_FASLG_SESN2 FAS_LC3_BECN1_FASLG DIABLO_FAS CIAP2_FASLG_UVRAG FAS_LC3_MMP9_FASLG FAS_LC3 LC3_FASLG_UVRAG DIABLO_FAS_FASLG_UVRAG ULK1_FASLG LC3_CIAP2_FASLG ATG12_FAS_LC3_FASLG CSE1L_FASLG DRAM_FAS_FASLG FAS_FASLG_RPS19BP1_UVRAG CBS_FASLG LC3_FASLG_SESN3 DIABLO_FAS_FASLG_SESN2 FASLG_HMGB2 FAS_FASLG_STAT3 FAS_LC3_FASLG_LAMP2 FAS_UVRAG ATG7_LC3_FASLG FAS_LC3_CDH1_FASLG LAMP1_FASLG ATG5_FAS_FASLG DIABLO_FAS_FASLG_SESN3 BNIP3_FASLG E2F1_FASLG_SESN2 FAS_LC3_TCF3_FASLG MMP9_FASLG LC3_ID2_FASLG E2F1_LC3_ID2_FASLG TKT_FASLG DRAM_LC3_FASLG FAS_LC3_BHLHE41_FASLG FASLG_STAT3 FAS_TCF3_FASLG DIABLO_FAS_LAMP1_FASLG AKT1_FASLG AKT1_FAS_FASLG DIABLO_DRAM_FAS_FASLG FASLG_MMP2 E2F1_ULK1_FASLG FAS_FASLG_SESN2_UVRAG DRAM_FASLG E2F1_TCF3_FASLG FAS_FASLG_RPS19BP1_SESN3 FASLG_SIRT1 LC3_FASLG_RPS19BP1 DIABLO_FAS_FRAP1_FASLG ATG12_FASLG LC3_MMP9_FASLG DIABLO_FAS_FASLG_STAT3 CIAP2_RAGE FAS_FASLG_SIRT1 ATG7_DIABLO_FAS_FASLG FAS_LAMP1 FAS_ULK1_FASLG CSE1L_FAS_LC3_FASLG ATG5_FASLG FAS_FASLG_NAMPT E2F1_LC3_MMP9_FASLG ATG3_FASLG LC3_FASLG_SIRT1 DRAM_FAS_FASLG_RPS19BP1 E2F1_FAS CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1 BECN1_FASLG ATG12_FAS_FASLG FAS_LC3_ULK1_FASLG E2F1_CIAP2 FAS_BECN1_FASLG DIABLO_FAS_FASLG_SIRT1 CASP8_FASLG ATG5_LC3_FASLG DIABLO_FAS_ID2_FASLG XIAP_CIAP2 LC3_BECN1_FASLG AKT1_DIABLO_FAS_FASLG CDR1_FASLG LC3_FASLG_STAT3 DIABLO_FAS_FASLG_NAMPT FASLG_NAMPT E2F1_FASLG_SESN3 ATG3_FAS_FASLG_SESN2 BNIP3_FAS AKT1_LC3_FASLG FAS_FASLG_RPS19BP1_SESN2 FASLG_LAMP2 FAS_FASLG_LAMP2 DIABLO_FAS_BECN1_FASLG AGER_FASLG LC3_TCF3_FASLG DIABLO_FAS_CDH1_FASLG ID2_FASLG LC3_FASLG_NAMPT ATG7_FAS_FASLG_UVRAG AIFM1_FASLG LC3_CDH1_FASLG DIABLO_FAS_FASLG_LAMP2 FASLG_SESN1 ATG12_LC3_FASLG FAS_FRAP1_FASLG_RPS19BP1 AIFM1_CIAP2 PTEN_CDH1_CIAP2 FAS_LAMP1_FASLG_UVRAG PRKAA1_CIAP2 LC3_FASLG_LAMP2 E2F1_FAS_LAMP1_FASLG BCL2L1_CIAP2 DIABLO_FASLG_SESN3 ATG7_FAS_FASLG_RPS19BP1 XIAP_FASLG FAS_CDH1_FASLG E2F1_FAS_FASLG_UVRAG CDH1_ID2_MMP9_TCF3
五种的组合 六种的组合 DIABLO_FAS_LC3_ID2_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2 DRAM_FAS_LC3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DIABLO_FAS_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_UVRAG
FAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_STAT3 DIABLO_FAS_LC3_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_SESN3 DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAG DIABLO_FAS_LC3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN3 DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_ID2_FASLG_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG5_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2 DIABLO_FAS_LC3_BECN1_FASLG BNIP3_DIABLO_FAS_LC3_ID2_FASLG DIABLO_FAS_LC3_CDH1_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_FASLG_SESN2 DIABLO_FAS_LC3_ID2_FASLG_SIRT1 DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAG FAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG DIABLO_FAS_LC3_FASLG_LAMP2 ATG3_FAS_LC3_FASLG_SESN2_SESN3 E2F1_FAS_LC3_ID2_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAG D IABLO_FAS_LC3_FASLG_NAMPT DIABLO_FAS_LC3_ID2_BECN1_FASLG DIABLO_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_ID2_FASLG_SESN2_UVRAG FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LC3_CDH1_ID2_FASLG FAS_LAMP1_LC3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 AKT1_DIABLO_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_SESN3 DIABLO_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_NAMPT DIABLO_FAS_LC3_BHLHE41_FASLG DIABLO_FAS_LC3_ID2_FASLG_SESN2 FAS_LC3_FASLG_STAT3_UVRAG DIABLO_FAS_LC3_ID2_FASLG_LAMP2 DIABLO_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_SESN2_SIRT1 E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_STAT3 BNIP3_FAS_FRAP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LAMP1_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_STAT3 FAS_LC3_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG AKT1_FAS_LC3_FASLG_UVRAG ATG5_FAS_LC3_ID2_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN3_UVRAG FAS_FRAP1_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAG BNIP3_FAS_LC3_FASLG_STAT3 DIABLO_DRAM_FAS_LC3_CDH1_FASLG FAS_LC3_CDH1_FASLG_UVRAG AKT1_DIABLO_FAS_LC3_ID2_FASLG FAS_LC3_FASLG_LAMP2_UVRAG BNIP3_DIABLO_FAS_LC3_MMP9_FASLG FAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_CDH1_FASLG_UVRAG ATG7_FAS_LC3_FASLG_UVRAG DIABLO_FAS_FRAP1_LC3_ID2_FASLG ATG7_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_FASLG_SIRT1 DIABLO_DRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LAMP1_LC3_FASLG BNIP3_DIABLO_DRAM_FAS_LC3_FASLG ATG7_BNIP3_FAS_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LAMP1_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG DIABLO_DRAM_FAS_LC3_BECN1_FASLG ATG5_DIABLO_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG DIABLO_FAS_LAMP1_LC3_ID2_FASLG ATG12_DIABLO_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_LAMP2_UVRAG E2F1_FAS_LC3_FASLG_SESN3 ATG5_FAS_LC3_FASLG_SESN2_UVRAG AKT1_BNIP3_FAS_LC3_FASLG FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 FAS_LC3_FASLG_NAMPT_UVRAG FAS_LAMP1_LC3_ID2_FASLG_UVRAG ATG12_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG PTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG
七种的组合 八种的组合 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG
FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1 ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3 DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG ATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2 ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAG DIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAG ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2 DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3 DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAG ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAG AKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAG ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG DRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2 ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2 DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG
。
38.如权利要求23～37中任一项所述的方法，其中，蛋白的表达水平或表达模式用选自以下方法中的一种或多种来检测：RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹、DNA微阵列、蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS或蛋白芯片。
39.一种预测肝癌预后的方法，所述方法包括：
(A)检测获自肝癌患者的样品中的选自由下表所示的基因组成的组的一种或至少两种基因的表达水平或表达模式中的一项或多项；和
(B)将步骤(A)的结果与对照组的测量结果进行比较，从而预测肝癌预后：
[表2]
40.如权利要求39所述的方法，其中，由基因组成的所述组还包含下表所示的基因：
[表3]
Figure FDA00003403731400841
41.如权利要求39或40所述的方法，其中，蛋白的表达水平或表达模式用选自以下方法中的一种或多种来检测：RT-PCR、竞争性RT-PCR、实时RT-PCR、RNA酶保护测定、RNA印迹、DNA微阵列、蛋白质印迹、ELISA(酶联免疫吸附测定)、放射免疫测定、放射免疫扩散、Ouchterlony免疫扩散、火箭免疫电泳、组织免疫染色、免疫沉淀测定、补体结合测定、FACS或蛋白芯片。
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