CN104968802A - 作为诊断标志物的新miRNA - Google Patents
作为诊断标志物的新miRNA Download PDFInfo
- Publication number
- CN104968802A CN104968802A CN201380068818.0A CN201380068818A CN104968802A CN 104968802 A CN104968802 A CN 104968802A CN 201380068818 A CN201380068818 A CN 201380068818A CN 104968802 A CN104968802 A CN 104968802A
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- Prior art keywords
- nucleic acid
- mirna
- acid molecule
- patient
- pathological condition
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (12)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12192979.8 | 2012-11-16 | ||
EP12192979.8A EP2733220B1 (en) | 2012-11-16 | 2012-11-16 | Novel miRNA as a diagnostic marker for Alzheimer's Disease |
PCT/EP2013/072920 WO2014075939A1 (en) | 2012-11-16 | 2013-11-04 | Novel mirnas as diagnostic markers |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104968802A true CN104968802A (zh) | 2015-10-07 |
CN104968802B CN104968802B (zh) | 2018-12-07 |
Family
ID=47191618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380068818.0A Active CN104968802B (zh) | 2012-11-16 | 2013-11-04 | 作为诊断标志物的新miRNA |
Country Status (4)
Country | Link |
---|---|
US (1) | US10457988B2 (zh) |
EP (1) | EP2733220B1 (zh) |
CN (1) | CN104968802B (zh) |
WO (1) | WO2014075939A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110246544A (zh) * | 2019-05-17 | 2019-09-17 | 暨南大学 | 一种基于整合分析的生物标志物选择方法及系统 |
CN112266957A (zh) * | 2020-11-17 | 2021-01-26 | 丽水市第二人民医院 | 预测cis临床孤立综合征转归的组合物 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180251836A1 (en) * | 2015-09-02 | 2018-09-06 | Hummingbird Diagnostics Gmbh | Novel mirna biomarkers and use thereof |
EP3184646B1 (de) * | 2015-12-22 | 2019-04-17 | Siemens Aktiengesellschaft | Spezifische signaturen in alzheimer durch multizentrische mirna-profile |
WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
WO2019112863A1 (en) * | 2017-12-06 | 2019-06-13 | FloTBI Inc. | Assay and point of care device utilizing saliva for diagnosis and treatment of neurological conditions affected brain health |
WO2019238807A1 (en) | 2018-06-15 | 2019-12-19 | Universitat Autonoma De Barcelona | CIRCULATING miRNAS AS BIOMARKERS FOR DIAGNOSIS OF MILD COGNITIVE IMPAIRMENT AND ALZHEIMER´S DISEASE |
CN110791560B (zh) * | 2019-11-06 | 2021-09-14 | 中国医学科学院医药生物技术研究所 | 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US29781A (en) * | 1860-08-28 | Apparatus fob filling bottles | ||
US20030013649A1 (en) * | 2000-01-31 | 2003-01-16 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
US7687616B1 (en) * | 2004-05-14 | 2010-03-30 | Rosetta Genomics Ltd | Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof |
JPWO2008029790A1 (ja) * | 2006-09-04 | 2010-01-21 | 協和発酵キリン株式会社 | 新規核酸 |
WO2009009457A1 (en) * | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Alzheimer's disease-specific micro-rna microarray and related methods |
ES2415245T5 (es) | 2007-08-22 | 2016-12-23 | Trovagene, Inc. | Métodos de uso de miARN para la detección de muerte celular in vivo |
CN104975089A (zh) | 2007-09-14 | 2015-10-14 | 俄亥俄州立大学研究基金会 | 人外周血微泡中的mirna表达和其用途 |
KR101889518B1 (ko) * | 2007-10-04 | 2018-08-17 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 마이크로MIRs |
EP2112235A1 (en) * | 2008-04-24 | 2009-10-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Compositions and methods for microRNA expression profiling of nasopharyngeal carcinoma |
US20100234445A1 (en) * | 2008-07-01 | 2010-09-16 | Weng Onn Lui | Patterns of known and novel small RNAS in human cervical cancer |
US9493832B2 (en) * | 2009-02-02 | 2016-11-15 | Cepheid | Methods of detecting sepsis |
WO2011057003A2 (en) * | 2009-11-04 | 2011-05-12 | Samuil Umansky | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
KR101235256B1 (ko) | 2010-09-13 | 2013-02-21 | 서울대학교산학협력단 | miRNA를 타겟으로 한 신경퇴행성 질환 치료 |
JP6021893B2 (ja) * | 2011-04-18 | 2016-11-09 | ディアミール, エルエルシーDiamir, Llc | 軽度認知機能障害(MCI)およびアルツハイマー病(AD)の早期検出ならびにモニタリングのために体液からのmiRNAを使用する方法 |
WO2013072920A2 (en) | 2011-09-08 | 2013-05-23 | Patel Jigar Dahyalal | An improved device for displaying reflected three-dimensional images(s) or video(s) |
CN103842003B (zh) | 2011-11-04 | 2016-10-26 | 旭化成医疗株式会社 | 血液处理用分离膜、以及安装有该膜的血液处理器 |
EP2733219B1 (en) | 2012-11-16 | 2017-09-20 | Siemens Aktiengesellschaft | Diagnostic miRNA markers for Alzheimer |
-
2012
- 2012-11-16 EP EP12192979.8A patent/EP2733220B1/en active Active
-
2013
- 2013-11-04 CN CN201380068818.0A patent/CN104968802B/zh active Active
- 2013-11-04 US US14/442,858 patent/US10457988B2/en active Active
- 2013-11-04 WO PCT/EP2013/072920 patent/WO2014075939A1/en active Application Filing
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110246544A (zh) * | 2019-05-17 | 2019-09-17 | 暨南大学 | 一种基于整合分析的生物标志物选择方法及系统 |
CN110246544B (zh) * | 2019-05-17 | 2021-03-19 | 暨南大学 | 一种基于整合分析的生物标志物选择方法及系统 |
CN112266957A (zh) * | 2020-11-17 | 2021-01-26 | 丽水市第二人民医院 | 预测cis临床孤立综合征转归的组合物 |
Also Published As
Publication number | Publication date |
---|---|
WO2014075939A1 (en) | 2014-05-22 |
US20150292013A1 (en) | 2015-10-15 |
EP2733220B1 (en) | 2017-10-18 |
EP2733220A1 (en) | 2014-05-21 |
CN104968802B (zh) | 2018-12-07 |
US10457988B2 (en) | 2019-10-29 |
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Effective date of registration: 20170622 Address after: Munich, Germany Applicant after: Siemens AG Address before: Munich, Germany Applicant before: Siemens AG Applicant before: SIEMENS HEALTHCARE DIAGNOSTICS |
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Effective date of registration: 20220126 Address after: Erlangen Patentee after: Siemens Healthineers AG Address before: Munich, Germany Patentee before: SIEMENS AG |