JP2013534421A5 - - Google Patents
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- Publication number
- JP2013534421A5 JP2013534421A5 JP2013517402A JP2013517402A JP2013534421A5 JP 2013534421 A5 JP2013534421 A5 JP 2013534421A5 JP 2013517402 A JP2013517402 A JP 2013517402A JP 2013517402 A JP2013517402 A JP 2013517402A JP 2013534421 A5 JP2013534421 A5 JP 2013534421A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- albumin
- binding polypeptide
- compound
- fusion protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 102000009027 Albumins Human genes 0.000 claims 22
- 108010088751 Albumins Proteins 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 11
- 108020001507 fusion proteins Proteins 0.000 claims 11
- 102000037865 fusion proteins Human genes 0.000 claims 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 150000003862 amino acid derivatives Chemical class 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000010647 peptide synthesis reaction Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39928510P | 2010-07-09 | 2010-07-09 | |
| US61/399,285 | 2010-07-09 | ||
| US40356110P | 2010-09-17 | 2010-09-17 | |
| US61/403,561 | 2010-09-17 | ||
| PCT/EP2011/061623 WO2012004384A2 (en) | 2010-07-09 | 2011-07-08 | Polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015204395A Division JP6486810B2 (ja) | 2010-07-09 | 2015-10-16 | ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534421A JP2013534421A (ja) | 2013-09-05 |
| JP2013534421A5 true JP2013534421A5 (https=) | 2014-08-14 |
| JP5827994B2 JP5827994B2 (ja) | 2015-12-02 |
Family
ID=44630120
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013517402A Active JP5827994B2 (ja) | 2010-07-09 | 2011-07-08 | ポリペプチド |
| JP2015204395A Active JP6486810B2 (ja) | 2010-07-09 | 2015-10-16 | ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015204395A Active JP6486810B2 (ja) | 2010-07-09 | 2015-10-16 | ポリペプチド |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9211344B2 (https=) |
| EP (2) | EP2933262B1 (https=) |
| JP (2) | JP5827994B2 (https=) |
| KR (1) | KR101884654B1 (https=) |
| CN (3) | CN103003296A (https=) |
| AU (1) | AU2011275766B2 (https=) |
| BR (1) | BR112013000452A2 (https=) |
| CA (1) | CA2804002C (https=) |
| DK (2) | DK2933262T3 (https=) |
| ES (2) | ES2676403T3 (https=) |
| IL (1) | IL223989B (https=) |
| LT (1) | LT2933262T (https=) |
| MX (1) | MX2013000314A (https=) |
| MY (1) | MY161679A (https=) |
| NO (1) | NO2933262T3 (https=) |
| NZ (1) | NZ604805A (https=) |
| PL (2) | PL2590993T3 (https=) |
| RU (1) | RU2577964C2 (https=) |
| TR (1) | TR201809437T4 (https=) |
| WO (1) | WO2012004384A2 (https=) |
| ZA (1) | ZA201300994B (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120165650A1 (en) | 2010-12-22 | 2012-06-28 | General Electric Company | Her2 binders |
| CN103003296A (zh) * | 2010-07-09 | 2013-03-27 | 阿菲博迪公司 | 多肽 |
| PT2621515T (pt) | 2010-09-28 | 2017-07-12 | Aegerion Pharmaceuticals Inc | Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada |
| BR112013029892A2 (pt) | 2011-05-21 | 2016-12-20 | Macrogenics Inc | polipeptídeo, molécula de ligação a antígeno, diacorpo e uso de uma porção polipeptídica de uma proteína de ligação a soro desimunizada |
| CN103957926B (zh) * | 2011-07-08 | 2018-07-03 | 安米林药品有限责任公司 | 具有增强的作用持续时间和降低的免疫原性的工程改造的多肽 |
| JP6006309B2 (ja) | 2011-07-08 | 2016-10-12 | アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc | 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド |
| EP3511339B1 (en) | 2012-02-20 | 2025-04-09 | IPC Research, LLC | Polypeptides binding to human complement c5 |
| JP2015512902A (ja) * | 2012-03-28 | 2015-04-30 | アフィボディ・アーベー | 経口投与 |
| JP2020033372A (ja) * | 2012-03-28 | 2020-03-05 | アフィボディ・アーベー | 経口投与 |
| WO2014048977A1 (en) * | 2012-09-25 | 2014-04-03 | Affibody Ab | Albumin binding polzpeptide |
| JP6440618B2 (ja) | 2012-10-05 | 2018-12-19 | アフィボディ・アーベー | Ｈｅｒ３結合ポリペプチド |
| WO2014064238A1 (en) * | 2012-10-25 | 2014-05-01 | Affibody Ab | Method for the separation of proteins containing an albumin-binding |
| CA2889037C (en) | 2012-10-25 | 2021-06-22 | Affibody Ab | Abd binding polypeptide |
| WO2014076177A1 (en) * | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| WO2014076179A1 (en) | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| JP6577868B2 (ja) * | 2012-12-19 | 2019-09-18 | アフィボディ・アーベー | 新規ポリペプチド |
| HK1213194A1 (zh) | 2013-03-14 | 2016-06-30 | Daiichi Sankyo Co., Ltd. | 用於新型的结合蛋白质pcsk9 |
| AU2014230018B2 (en) * | 2013-03-15 | 2018-02-22 | Affibody Ab | New polypeptides |
| MX2015014438A (es) | 2013-04-18 | 2016-05-18 | Armo Biosciences Inc | Metodos de uso de interleucina-10 para tratar enfermedades y trastornos. |
| EP3010527B1 (en) | 2013-06-17 | 2018-08-08 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| BR112016003142A2 (pt) | 2013-08-28 | 2017-10-17 | Swedish Orphan Biovitrum Ab Publ | ligação de polipeptídeos estáveis ao c5 do complemento humano |
| MX367423B (es) | 2013-08-28 | 2019-08-21 | Affibody Ab | Polipeptidos de union a c5. |
| CN105658232A (zh) | 2013-08-30 | 2016-06-08 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素-10治疗疾病和病症的方法 |
| CN120242030A (zh) | 2013-11-11 | 2025-07-04 | 阿尔莫生物科技股份有限公司 | 将白细胞介素-10用于治疗疾病和病症的方法 |
| US10167322B2 (en) | 2013-12-20 | 2019-01-01 | Affibody Ab | Engineered albumin binding polypeptide |
| WO2015177175A2 (en) | 2014-05-22 | 2015-11-26 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| MX386297B (es) | 2014-09-29 | 2025-03-18 | Univ Duke | Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1. |
| WO2016060996A2 (en) | 2014-10-14 | 2016-04-21 | Armo Biosciences, Inc. | Interleukin-15 compositions and uses thereof |
| AU2015336101A1 (en) | 2014-10-22 | 2017-04-20 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| EP3245224B1 (en) | 2015-01-12 | 2020-07-15 | Affibody AB | Il-17a-binding polypeptides |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| KR102427117B1 (ko) * | 2015-04-02 | 2022-07-29 | 몰리큘라 파트너스 아게 | 혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인 |
| US20160361415A1 (en) | 2015-05-28 | 2016-12-15 | Armo Biosciences, Inc. | Methods of Using Interleukin-10 for Treating Diseases and Disorders |
| KR20180038553A (ko) | 2015-08-25 | 2018-04-16 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법 |
| KR102806328B1 (ko) | 2017-07-11 | 2025-05-14 | 알렉시온 파마슈티칼스, 인코포레이티드 | 보체 성분 c5 또는 혈청 알부민에 결합하는 폴리펩티드 및 그의 융합 단백질 |
| CN111164104A (zh) | 2017-08-09 | 2020-05-15 | 麻省理工学院 | 白蛋白结合肽缀合物及其方法 |
| CN108362873B (zh) * | 2018-02-13 | 2021-06-01 | 苏州仁端生物医药科技有限公司 | 一种镉离子检测试剂盒及其应用 |
| JP7545894B2 (ja) * | 2018-03-13 | 2024-09-05 | アフィボディ アクティエボラーグ | 新規足場に基づくポリペプチド |
| CN113710229B (zh) | 2019-02-25 | 2026-01-06 | 芝加哥大学 | 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物 |
| CA3138805A1 (en) | 2019-06-04 | 2020-12-10 | Johannes Schilling | Designed ankyrin repeat domain with improved stability |
| EP4017521A1 (en) | 2019-09-02 | 2022-06-29 | Biotest AG | Factor viii protein with increased half-life |
| EP3785726A1 (en) | 2019-09-02 | 2021-03-03 | Biotest AG | Factor viii protein with increased half-life |
| WO2021089695A1 (en) | 2019-11-05 | 2021-05-14 | Affibody Ab | Polypeptides |
| CN115298193B (zh) | 2020-02-05 | 2026-03-31 | 伊莱利利公司 | 串联树脂反应器的肽合成仪 |
| US20230190881A1 (en) | 2020-02-17 | 2023-06-22 | Biotest Ag | Subcutaneous administration of factor viii |
| EP3878515A1 (en) | 2020-03-09 | 2021-09-15 | Hober Biotech AB | Therapeutic agent targeting her2 |
| KR20230123989A (ko) | 2020-12-21 | 2023-08-24 | 애피바디 에이비 | 신규 폴리펩티드 |
| EP4291251B1 (en) | 2021-02-15 | 2025-02-19 | Affibody AB | Her2-binding polypeptide |
| CN113416683B (zh) * | 2021-06-01 | 2023-05-02 | 南昌大学 | 一种大肠杆菌Nissle 1917基因工程菌及其制备方法和应用 |
| AR128475A1 (es) | 2022-02-08 | 2024-05-15 | Affibody Ab | Polipéptidos y proteínas de fusión con afinidad de unión por tslp |
| TW202448926A (zh) | 2023-02-17 | 2024-12-16 | 比利時商艾伯霖克斯公司 | 結合新生兒fc受體之多肽 |
| CN121038816A (zh) | 2023-05-04 | 2025-11-28 | 阿菲博迪公司 | 新多肽 |
| WO2024263059A1 (ru) * | 2023-06-21 | 2024-12-26 | Общество С Ограниченной Ответственностью "Герофарм" | Гибридные белки-предшественники пептидных иммуногенов ‒ компонентов вакцины против covid-19 |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| TW202545983A (zh) | 2024-01-25 | 2025-12-01 | 瑞典商艾菲博迪公司 | 新穎多肽 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US6362225B1 (en) | 1999-01-21 | 2002-03-26 | George Andreakos | Target therapies for treating common viral infections |
| EP1240337B1 (en) | 1999-12-24 | 2006-08-23 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| US7288265B1 (en) | 2000-10-16 | 2007-10-30 | Lectec Corporation | Treating viral infection at smallpox vaccination site |
| AU2002246737B2 (en) * | 2000-12-29 | 2007-03-01 | Savient Pharmaceuticals, Inc. | Specific human antibodies for selective cancer therapy |
| US7316819B2 (en) | 2001-03-08 | 2008-01-08 | Unigene Laboratories, Inc. | Oral peptide pharmaceutical dosage form and method of production |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1631308B1 (en) | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| JP5634008B2 (ja) * | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
| US20050282756A1 (en) | 2004-06-18 | 2005-12-22 | Mehta Nozer M | Oral delivery of peptide pharmaceutical compositions |
| CN101128487B (zh) * | 2004-12-02 | 2012-10-10 | 杜门蒂斯有限公司 | 靶向血清白蛋白和glp-1或pyy的双特异性结构域抗体 |
| US8093207B2 (en) | 2005-12-09 | 2012-01-10 | Unigene Laboratories, Inc. | Fast-acting oral peptide pharmaceutical products |
| EA200802348A1 (ru) * | 2006-05-24 | 2009-08-28 | Байер Шеринг Фарма Акциенгезельшафт | ЧЕЛОВЕЧЕСКИЙ ВЫСОКОАФФИННЫЙ И ГУМАНИЗИРОВАННЫЙ АНТИ-α5β1 ИНТЕГРИН С ФУНКЦИЕЙ БЛОКИРУЮЩЕГО АНТИТЕЛА С ОСЛАБЛЕННОЙ ИММУНОГЕННОСТЬЮ |
| AU2007284801A1 (en) | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
| AU2007293614A1 (en) * | 2006-09-08 | 2008-03-13 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| ATE536369T1 (de) | 2006-10-11 | 2011-12-15 | Ablynx Nv | Im wesentlichen ph-wert-unabhängigerweise an serumproteine bindende aminosäuresequenzen, verbindungen, die diese enthalten, und deren verwendung |
| EP2190863B1 (en) * | 2007-07-31 | 2015-09-02 | Affibody AB | New albumin binding compositions, methods and uses |
| EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
| NZ588603A (en) | 2008-03-26 | 2012-03-30 | Oramed Ltd | Methods and compositions for oral administration of a protein of up to 100000 Daltaons, a first protease inhibitor and a second protease inhibitor wherein said protease inhibitors inhibit trypsin |
| CN101294178A (zh) | 2008-05-26 | 2008-10-29 | 江南大学 | 一种用两阶段培养法提高发酵生产透明质酸产量的方法 |
| CN101294187B (zh) * | 2008-06-06 | 2013-07-31 | 暨南大学 | 一种缓释生物活性多肽的方法与应用 |
| JP5740689B2 (ja) | 2008-08-18 | 2015-06-24 | エンテラ バイオ エルティーディー． | タンパク質の経口投与用の方法および組成物 |
| WO2010054699A1 (en) * | 2008-11-17 | 2010-05-20 | Affibody Ab | Conjugates of albumin binding domain |
| EP2437767B1 (en) | 2009-06-01 | 2015-07-08 | MedImmune, LLC | Molecules with extended half-lives and uses thereof |
| CN103003296A (zh) | 2010-07-09 | 2013-03-27 | 阿菲博迪公司 | 多肽 |
| US20120027058A1 (en) | 2010-07-29 | 2012-02-02 | The Regents Of The University Of Michigan | Portable, wireless multi-channel impedance analyzer |
| PT2621515T (pt) | 2010-09-28 | 2017-07-12 | Aegerion Pharmaceuticals Inc | Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada |
| CN103347532A (zh) | 2011-02-04 | 2013-10-09 | 爱奇司治疗公司 | 口服可生物利用肽药物组合物及其方法 |
| CN103957926B (zh) | 2011-07-08 | 2018-07-03 | 安米林药品有限责任公司 | 具有增强的作用持续时间和降低的免疫原性的工程改造的多肽 |
| JP2015512902A (ja) | 2012-03-28 | 2015-04-30 | アフィボディ・アーベー | 経口投与 |
| WO2014048977A1 (en) | 2012-09-25 | 2014-04-03 | Affibody Ab | Albumin binding polzpeptide |
| US10167322B2 (en) | 2013-12-20 | 2019-01-01 | Affibody Ab | Engineered albumin binding polypeptide |
-
2011
- 2011-07-08 CN CN2011800330970A patent/CN103003296A/zh active Pending
- 2011-07-08 RU RU2013102953/10A patent/RU2577964C2/ru active
- 2011-07-08 DK DK15165722.8T patent/DK2933262T3/en active
- 2011-07-08 PL PL11743207T patent/PL2590993T3/pl unknown
- 2011-07-08 PL PL15165722T patent/PL2933262T3/pl unknown
- 2011-07-08 MX MX2013000314A patent/MX2013000314A/es active IP Right Grant
- 2011-07-08 CN CN201910770209.9A patent/CN110437320B/zh active Active
- 2011-07-08 WO PCT/EP2011/061623 patent/WO2012004384A2/en not_active Ceased
- 2011-07-08 JP JP2013517402A patent/JP5827994B2/ja active Active
- 2011-07-08 BR BR112013000452-5A patent/BR112013000452A2/pt not_active Application Discontinuation
- 2011-07-08 MY MYPI2012005497A patent/MY161679A/en unknown
- 2011-07-08 CA CA2804002A patent/CA2804002C/en active Active
- 2011-07-08 CN CN201910770466.2A patent/CN110437321A/zh active Pending
- 2011-07-08 AU AU2011275766A patent/AU2011275766B2/en active Active
- 2011-07-08 NZ NZ604805A patent/NZ604805A/en unknown
- 2011-07-08 ES ES15165722.8T patent/ES2676403T3/es active Active
- 2011-07-08 TR TR2018/09437T patent/TR201809437T4/tr unknown
- 2011-07-08 US US13/808,713 patent/US9211344B2/en active Active
- 2011-07-08 DK DK11743207.0T patent/DK2590993T3/en active
- 2011-07-08 LT LTEP15165722.8T patent/LT2933262T/lt unknown
- 2011-07-08 KR KR1020137003270A patent/KR101884654B1/ko active Active
- 2011-07-08 ES ES11743207.0T patent/ES2540114T3/es active Active
- 2011-07-08 NO NO15165722A patent/NO2933262T3/no unknown
- 2011-07-08 EP EP15165722.8A patent/EP2933262B1/en active Active
- 2011-07-08 EP EP20110743207 patent/EP2590993B1/en active Active
-
2012
- 2012-12-30 IL IL223989A patent/IL223989B/en active IP Right Grant
-
2013
- 2013-02-06 ZA ZA2013/00994A patent/ZA201300994B/en unknown
-
2015
- 2015-10-16 JP JP2015204395A patent/JP6486810B2/ja active Active
- 2015-12-01 US US14/955,647 patent/US10329331B2/en active Active
-
2019
- 2019-05-08 US US16/406,415 patent/US20190375799A1/en not_active Abandoned
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