JP2013530680A5 - - Google Patents
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- Publication number
- JP2013530680A5 JP2013530680A5 JP2013502936A JP2013502936A JP2013530680A5 JP 2013530680 A5 JP2013530680 A5 JP 2013530680A5 JP 2013502936 A JP2013502936 A JP 2013502936A JP 2013502936 A JP2013502936 A JP 2013502936A JP 2013530680 A5 JP2013530680 A5 JP 2013530680A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- pluripotent stem
- wnt
- culture
- human pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 15
- 238000000034 method Methods 0.000 claims 13
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 2
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 2
- 101000598781 Homo sapiens Oxidative stress-responsive serine-rich protein 1 Proteins 0.000 claims 2
- 101000613717 Homo sapiens Protein odd-skipped-related 1 Proteins 0.000 claims 2
- 101001098464 Homo sapiens Serine/threonine-protein kinase OSR1 Proteins 0.000 claims 2
- 102100037780 Oxidative stress-responsive serine-rich protein 1 Human genes 0.000 claims 2
- 108700008625 Reporter Genes Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000012091 fetal bovine serum Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 210000003716 mesoderm Anatomy 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 1
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical group CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 claims 1
- 108010047357 Luminescent Proteins Proteins 0.000 claims 1
- 102000006830 Luminescent Proteins Human genes 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36637910P | 2010-07-21 | 2010-07-21 | |
| US61/366,379 | 2010-07-21 | ||
| US201161451825P | 2011-03-11 | 2011-03-11 | |
| US61/451,825 | 2011-03-11 | ||
| PCT/JP2011/067181 WO2012011610A1 (en) | 2010-07-21 | 2011-07-21 | Method for inducing differentiation of human pluripotent stem cell into intermediate mesoderm cell |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013530680A JP2013530680A (ja) | 2013-08-01 |
| JP2013530680A5 true JP2013530680A5 (enExample) | 2014-09-04 |
| JP5896360B2 JP5896360B2 (ja) | 2016-04-13 |
Family
ID=45497017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013502936A Active JP5896360B2 (ja) | 2010-07-21 | 2011-07-21 | ヒト多能性幹細胞から中間中胚葉細胞への分化誘導方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9121011B2 (enExample) |
| EP (1) | EP2596096B1 (enExample) |
| JP (1) | JP5896360B2 (enExample) |
| WO (1) | WO2012011610A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2794860B1 (en) | 2011-12-19 | 2017-05-03 | Kyoto University | Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells |
| EP2837681B1 (en) * | 2012-04-06 | 2018-02-21 | Kyoto University | Method for inducing erythropoietin-producing cell |
| KR20130119683A (ko) * | 2012-04-24 | 2013-11-01 | 사회복지법인 삼성생명공익재단 | 줄기세포 배양 배지 및 이를 이용한 줄기세포의 배양방법 |
| CN105228557A (zh) * | 2013-03-21 | 2016-01-06 | 纽约市哥伦比亚大学理事会 | 用于牙组织再生的组合物和方法 |
| WO2014168264A1 (ja) * | 2013-04-12 | 2014-10-16 | 国立大学法人京都大学 | 肺胞上皮前駆細胞の誘導方法 |
| EP3020803B1 (en) * | 2013-06-11 | 2020-03-11 | Kyoto University | Method for producing renal precursor cells |
| AU2014280843B2 (en) | 2013-06-14 | 2017-04-20 | The University Of Queensland | Renal progenitor cells |
| RU2016106953A (ru) * | 2013-07-29 | 2017-08-31 | Ф.Хоффманн-Ля Рош Аг | Способ дифференциации плюрипотентных стволовых клеток в мультикомпетентные почечные клетки-предшественники |
| JP6455729B2 (ja) * | 2013-10-18 | 2019-01-23 | 国立大学法人 熊本大学 | 多能性幹細胞からの腎臓誘導法 |
| AU2015353853B2 (en) | 2014-11-25 | 2020-10-15 | President And Fellows Of Harvard College | Methods for generation of podocytes from pluripotent stem cells and cells produced by the same |
| AU2014277667B2 (en) * | 2014-12-15 | 2022-07-14 | The University Of Queensland | Differentiation of pluripotent stem cells to form renal organoids |
| JP6738572B2 (ja) | 2015-03-06 | 2020-08-12 | 国立大学法人京都大学 | 肺胞上皮細胞の分化誘導法 |
| WO2017002888A1 (ja) * | 2015-06-29 | 2017-01-05 | 国立大学法人京都大学 | 多能性幹細胞から生殖細胞への分化誘導方法 |
| JP6646311B2 (ja) * | 2015-07-17 | 2020-02-14 | 国立大学法人京都大学 | 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法 |
| AU2016321170B2 (en) * | 2015-09-08 | 2022-09-01 | Fujifilm Cellular Dynamics | Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells |
| RU2730861C2 (ru) | 2015-09-11 | 2020-08-26 | Астеллас Фарма Инк. | Способ продуцирования почечных клеток-предшественников |
| CN105850980B (zh) * | 2016-04-14 | 2018-06-12 | 广州赛莱拉干细胞科技股份有限公司 | 一种角膜缘干细胞的冻存液及冻存方法 |
| EP3519558B1 (en) | 2016-09-28 | 2023-08-09 | Organovo, Inc. | Use of engineered renal tissues in assays |
| KR102594102B1 (ko) | 2017-05-25 | 2023-10-25 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 중간 중배엽 세포로부터 신장 전구 세포로의 분화 유도 방법 및 다능성 줄기세포로부터 신장 전구 세포로의 분화 유도 방법 |
| US20210123027A1 (en) | 2018-10-10 | 2021-04-29 | National University Corporation Tottori University | Method for producing human induced pluripotent stem cells containing exogenous chromosome |
| US20220010283A1 (en) * | 2018-10-31 | 2022-01-13 | Kyoto University | Method for producing pluripotent stem cell having released differentiation resistance to mesendoderm |
| US20220169977A1 (en) | 2019-03-29 | 2022-06-02 | Kaneka Corporation | Cell population including pluripotent stem cells and production method thereof |
| CN110656089B (zh) * | 2019-10-15 | 2021-02-09 | 上海捷易生物科技有限公司 | 一种将iPS细胞定向诱导分化到成熟神经元的方法 |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| US20250186507A1 (en) * | 2022-02-15 | 2025-06-12 | National University Corporation Kobe University | Method for preparing human pluripotent stem cell-derived leydig-like cells, and human pluripotent stem cell-derived leydig-like cell population |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| NZ569530A (en) | 2005-12-13 | 2011-07-29 | Univ Kyoto | Nuclear reprogramming factor |
| CA2676044C (en) * | 2007-01-30 | 2019-10-22 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
-
2011
- 2011-07-21 WO PCT/JP2011/067181 patent/WO2012011610A1/en not_active Ceased
- 2011-07-21 JP JP2013502936A patent/JP5896360B2/ja active Active
- 2011-07-21 EP EP11809770.8A patent/EP2596096B1/en not_active Not-in-force
- 2011-07-21 US US13/811,163 patent/US9121011B2/en not_active Expired - Fee Related
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