JP2013529505A5 - - Google Patents
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- Publication number
- JP2013529505A5 JP2013529505A5 JP2013516654A JP2013516654A JP2013529505A5 JP 2013529505 A5 JP2013529505 A5 JP 2013529505A5 JP 2013516654 A JP2013516654 A JP 2013516654A JP 2013516654 A JP2013516654 A JP 2013516654A JP 2013529505 A5 JP2013529505 A5 JP 2013529505A5
- Authority
- JP
- Japan
- Prior art keywords
- methacrylate
- acrylate
- device material
- monomer
- polymeric device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims 20
- -1 2- (4-propylphenyl) ethyl Chemical group 0.000 claims 14
- 239000000178 monomer Substances 0.000 claims 14
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- XFCMNSHQOZQILR-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOC(=O)C(C)=C XFCMNSHQOZQILR-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- INQDDHNZXOAFFD-UHFFFAOYSA-N 2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOCCOC(=O)C=C INQDDHNZXOAFFD-UHFFFAOYSA-N 0.000 claims 2
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 claims 2
- ILZXXGLGJZQLTR-UHFFFAOYSA-N 2-phenylethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC1=CC=CC=C1 ILZXXGLGJZQLTR-UHFFFAOYSA-N 0.000 claims 2
- HPSGLFKWHYAKSF-UHFFFAOYSA-N 2-phenylethyl prop-2-enoate Chemical compound C=CC(=O)OCCC1=CC=CC=C1 HPSGLFKWHYAKSF-UHFFFAOYSA-N 0.000 claims 2
- MXNDNUJKPFXJJX-UHFFFAOYSA-N 4-phenylbutyl prop-2-enoate Chemical compound C=CC(=O)OCCCCC1=CC=CC=C1 MXNDNUJKPFXJJX-UHFFFAOYSA-N 0.000 claims 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 2
- 239000006096 absorbing agent Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000003086 colorant Substances 0.000 claims 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- RCTZKJGLWRCHMI-UHFFFAOYSA-N (2-ethylphenyl) 2-methylprop-2-eneperoxoate Chemical compound CCC1=CC=CC=C1OOC(=O)C(C)=C RCTZKJGLWRCHMI-UHFFFAOYSA-N 0.000 claims 1
- HYZJSTPCAKOIHY-UHFFFAOYSA-N (2-ethylphenyl) prop-2-eneperoxoate Chemical compound CCC1=CC=CC=C1OOC(=O)C=C HYZJSTPCAKOIHY-UHFFFAOYSA-N 0.000 claims 1
- AOUAMFARIYTDLK-UHFFFAOYSA-N (4-methylphenyl) 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1=CC=C(C)C=C1 AOUAMFARIYTDLK-UHFFFAOYSA-N 0.000 claims 1
- OJNXPAPLAAGFBJ-UHFFFAOYSA-N (4-methylphenyl) prop-2-enoate Chemical compound CC1=CC=C(OC(=O)C=C)C=C1 OJNXPAPLAAGFBJ-UHFFFAOYSA-N 0.000 claims 1
- 125000003070 2-(2-chlorophenyl)ethyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- NCGHOOVBTJLVFY-UHFFFAOYSA-N 2-(2-methylphenyl)ethyl prop-2-enoate Chemical compound CC1=CC=CC=C1CCOC(=O)C=C NCGHOOVBTJLVFY-UHFFFAOYSA-N 0.000 claims 1
- JJBFVQSGPLGDNX-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC(C)COC(=O)C(C)=C JJBFVQSGPLGDNX-UHFFFAOYSA-N 0.000 claims 1
- JPTHRABUTMVMHR-UHFFFAOYSA-N 2-(3-methylphenyl)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC1=CC=CC(C)=C1 JPTHRABUTMVMHR-UHFFFAOYSA-N 0.000 claims 1
- YLLMOWFLCNIVRF-UHFFFAOYSA-N 2-(3-methylphenyl)ethyl prop-2-enoate Chemical compound CC1=CC=CC(CCOC(=O)C=C)=C1 YLLMOWFLCNIVRF-UHFFFAOYSA-N 0.000 claims 1
- HKGJTSSOXHQYDQ-UHFFFAOYSA-N 2-(4-methylphenyl)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC1=CC=C(C)C=C1 HKGJTSSOXHQYDQ-UHFFFAOYSA-N 0.000 claims 1
- NQURUJFRSFIIAA-UHFFFAOYSA-N 2-(4-methylphenyl)ethyl prop-2-enoate Chemical compound CC1=CC=C(CCOC(=O)C=C)C=C1 NQURUJFRSFIIAA-UHFFFAOYSA-N 0.000 claims 1
- LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 claims 1
- CWVFILUMTNJKBN-UHFFFAOYSA-N 2-phenylmethoxyethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCC1=CC=CC=C1 CWVFILUMTNJKBN-UHFFFAOYSA-N 0.000 claims 1
- ROJWTNWAEYEKMO-UHFFFAOYSA-N 2-phenylmethoxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCC1=CC=CC=C1 ROJWTNWAEYEKMO-UHFFFAOYSA-N 0.000 claims 1
- HTWRFCRQSLVESJ-UHFFFAOYSA-N 3-(2-methylprop-2-enoyloxy)propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCOC(=O)C(C)=C HTWRFCRQSLVESJ-UHFFFAOYSA-N 0.000 claims 1
- DJENTNKTVLSRNS-UHFFFAOYSA-N 3-phenylmethoxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCOCC1=CC=CC=C1 DJENTNKTVLSRNS-UHFFFAOYSA-N 0.000 claims 1
- SJOIDEGZPXSHOC-UHFFFAOYSA-N 3-phenylmethoxypropyl prop-2-enoate Chemical compound C=CC(=O)OCCCOCC1=CC=CC=C1 SJOIDEGZPXSHOC-UHFFFAOYSA-N 0.000 claims 1
- RXXZODOCQIRRQA-UHFFFAOYSA-N 3-phenylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCC1=CC=CC=C1 RXXZODOCQIRRQA-UHFFFAOYSA-N 0.000 claims 1
- PKBZUGSITIBLFK-UHFFFAOYSA-N 3-phenylpropyl prop-2-enoate Chemical compound C=CC(=O)OCCCC1=CC=CC=C1 PKBZUGSITIBLFK-UHFFFAOYSA-N 0.000 claims 1
- XOJWAAUYNWGQAU-UHFFFAOYSA-N 4-(2-methylprop-2-enoyloxy)butyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCOC(=O)C(C)=C XOJWAAUYNWGQAU-UHFFFAOYSA-N 0.000 claims 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical group FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims 1
- IGVCHZAHFGFESB-UHFFFAOYSA-N 4-phenylbutyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCC1=CC=CC=C1 IGVCHZAHFGFESB-UHFFFAOYSA-N 0.000 claims 1
- JHWGFJBTMHEZME-UHFFFAOYSA-N 4-prop-2-enoyloxybutyl prop-2-enoate Chemical compound C=CC(=O)OCCCCOC(=O)C=C JHWGFJBTMHEZME-UHFFFAOYSA-N 0.000 claims 1
- RXPPWNDYCIQFQB-UHFFFAOYSA-N 5-phenylpentyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCCC1=CC=CC=C1 RXPPWNDYCIQFQB-UHFFFAOYSA-N 0.000 claims 1
- FBOYEYXUKAKVDL-UHFFFAOYSA-N 5-phenylpentyl prop-2-enoate Chemical compound C=CC(=O)OCCCCCC1=CC=CC=C1 FBOYEYXUKAKVDL-UHFFFAOYSA-N 0.000 claims 1
- SAPGBCWOQLHKKZ-UHFFFAOYSA-N 6-(2-methylprop-2-enoyloxy)hexyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCCCOC(=O)C(C)=C SAPGBCWOQLHKKZ-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- DSLBBTFHUSNPGC-UHFFFAOYSA-N CC(=C)C(=O)OCC1=CC=C(C)C=C1.CC(=C)C(=O)OCCC1=CC=CC=C1C Chemical compound CC(=C)C(=O)OCC1=CC=C(C)C=C1.CC(=C)C(=O)OCCC1=CC=CC=C1C DSLBBTFHUSNPGC-UHFFFAOYSA-N 0.000 claims 1
- 239000004971 Cross linker Substances 0.000 claims 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
- AOJOEFVRHOZDFN-UHFFFAOYSA-N benzyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC1=CC=CC=C1 AOJOEFVRHOZDFN-UHFFFAOYSA-N 0.000 claims 1
- GCTPMLUUWLLESL-UHFFFAOYSA-N benzyl prop-2-enoate Chemical compound C=CC(=O)OCC1=CC=CC=C1 GCTPMLUUWLLESL-UHFFFAOYSA-N 0.000 claims 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- QIWKUEJZZCOPFV-UHFFFAOYSA-N phenyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1=CC=CC=C1 QIWKUEJZZCOPFV-UHFFFAOYSA-N 0.000 claims 1
- WRAQQYDMVSCOTE-UHFFFAOYSA-N phenyl prop-2-enoate Chemical compound C=CC(=O)OC1=CC=CC=C1 WRAQQYDMVSCOTE-UHFFFAOYSA-N 0.000 claims 1
- FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35696310P | 2010-06-21 | 2010-06-21 | |
| US61/356,963 | 2010-06-21 | ||
| PCT/US2011/041070 WO2011163126A1 (en) | 2010-06-21 | 2011-06-20 | High refractive index, acrylic ophthalmic device materials with reduced glistenings |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529505A JP2013529505A (ja) | 2013-07-22 |
| JP2013529505A5 true JP2013529505A5 (https=) | 2013-09-26 |
| JP5363683B2 JP5363683B2 (ja) | 2013-12-11 |
Family
ID=44485011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516654A Active JP5363683B2 (ja) | 2010-06-21 | 2011-06-20 | グリスニングが低い、高屈折率の眼科的アクリルデバイス材料 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8449610B2 (https=) |
| EP (1) | EP2582409B1 (https=) |
| JP (1) | JP5363683B2 (https=) |
| KR (1) | KR101353975B1 (https=) |
| CN (1) | CN102946913B (https=) |
| AR (1) | AR081963A1 (https=) |
| AU (1) | AU2011271228B2 (https=) |
| BR (1) | BR112012032626A2 (https=) |
| CA (1) | CA2801076C (https=) |
| ES (1) | ES2523387T3 (https=) |
| IL (1) | IL223487A (https=) |
| MX (1) | MX2012015178A (https=) |
| NZ (1) | NZ603881A (https=) |
| PH (1) | PH12012502514A1 (https=) |
| RU (1) | RU2571091C2 (https=) |
| SG (1) | SG186289A1 (https=) |
| TW (1) | TWI473823B (https=) |
| WO (1) | WO2011163126A1 (https=) |
| ZA (1) | ZA201209331B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI517861B (zh) | 2011-02-08 | 2016-01-21 | 諾華公司 | 低黏度疏水性眼科裝置材料 |
| TWI513768B (zh) | 2011-06-01 | 2015-12-21 | Novartis Ag | 疏水性丙烯酸系眼內水晶體材料 |
| TWI551646B (zh) | 2011-06-03 | 2016-10-01 | 諾華公司 | 疏水性丙烯酸系眼內水晶體材料 |
| CN103183822B (zh) * | 2011-12-28 | 2016-03-30 | 辽宁奥克化学股份有限公司 | 一种不饱和氨酯聚氧烷基醚及其制备方法 |
| AU2012369994B2 (en) * | 2012-02-15 | 2014-12-04 | Alcon Inc. | Ophthalmic and otorhinolaryngological device materials containing a multi-arm PEG macromer |
| GB201314455D0 (en) * | 2013-08-13 | 2013-09-25 | Contamac Ltd | Monomers for use in a polymerizable composition and high refractive index polymer for opthalmic applications |
| JP6166479B2 (ja) | 2013-12-04 | 2017-07-19 | ノバルティス アーゲー | 高い屈折率および最小限のグリスニングを有する軟質アクリル材料 |
| US10351637B2 (en) | 2014-05-07 | 2019-07-16 | Tubitak | Formulation and lens manufacturing process for the production of intraocular lens (IOL) |
| CN106999628A (zh) * | 2014-12-16 | 2017-08-01 | 诺华股份有限公司 | 用于眼科装置的疏水性丙烯酸酯‑丙烯酰胺共聚物 |
| EP3200840B1 (en) | 2014-12-16 | 2021-11-17 | Alcon Inc. | Low-water content acrylate-acrylamide copolymers for ophthalmic devices |
| JP6397136B2 (ja) | 2015-02-16 | 2018-09-26 | ノバルティス アーゲー | 高屈折率を有するウエットパック眼内レンズ材料 |
| CN105536053B (zh) * | 2015-12-29 | 2018-10-02 | 哈尔滨工业大学 | 一种作为人工晶状体材料的亲水性形状记忆水凝胶 |
| US20190185629A1 (en) * | 2016-08-05 | 2019-06-20 | Microoptx Inc. | Polymeric devices and methods of making |
| EP3363794A1 (en) * | 2017-02-15 | 2018-08-22 | Merck Patent GmbH | Bis-compounds for optically active devices |
| AU2018279271B2 (en) * | 2017-06-05 | 2022-11-10 | Alcon Inc. | High refractive index, high Abbe number intraocular lens materials |
| TW201927263A (zh) | 2017-12-18 | 2019-07-16 | 瑞士商諾華公司 | 觸覺力分佈得到改善的眼內透鏡平台 |
| US11478630B2 (en) * | 2017-12-18 | 2022-10-25 | Dan Sachs | Devices, systems and methods for therapeutic muscle stimulation |
| TW201927262A (zh) | 2017-12-20 | 2019-07-16 | 瑞士商諾華公司 | 具有前偏置光學設計之眼內透鏡 |
| EP3745999B1 (en) * | 2018-01-31 | 2026-04-29 | Menicon Co., Ltd. | Intraocular lens |
| EP3934705B1 (en) * | 2019-03-07 | 2025-11-19 | Teleon Holding B.V. | Intraocular lens compositions |
| US11708440B2 (en) | 2019-05-03 | 2023-07-25 | Johnson & Johnson Surgical Vision, Inc. | High refractive index, high Abbe compositions |
| KR102894609B1 (ko) | 2019-05-03 | 2025-12-04 | 존슨 앤드 존슨 서지컬 비전, 인코포레이티드 | 고 굴절률, 고 아베 조성물 |
| US11795252B2 (en) | 2020-10-29 | 2023-10-24 | Johnson & Johnson Surgical Vision, Inc. | Compositions with high refractive index and Abbe number |
| CN113527567B (zh) * | 2021-07-26 | 2023-01-24 | 康小林 | 疏水性无闪光点高折光率眼科聚合物材料 |
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| TWI426932B (zh) | 2007-10-05 | 2014-02-21 | Alcon Inc | 眼科與耳鼻喉科裝置材料（三） |
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| TW201000155A (en) | 2008-05-06 | 2010-01-01 | Alcon Inc | High refractive index ophthalmic device materials |
| ES2526253T3 (es) | 2009-08-24 | 2015-01-08 | Novartis Ag | Materiales para dispositivos oftálmicos y otorrinolaringológicos |
-
2011
- 2011-06-17 TW TW100121212A patent/TWI473823B/zh not_active IP Right Cessation
- 2011-06-20 KR KR1020137000765A patent/KR101353975B1/ko not_active Expired - Fee Related
- 2011-06-20 WO PCT/US2011/041070 patent/WO2011163126A1/en not_active Ceased
- 2011-06-20 CN CN201180030684.4A patent/CN102946913B/zh not_active Expired - Fee Related
- 2011-06-20 EP EP11729519.6A patent/EP2582409B1/en active Active
- 2011-06-20 SG SG2012091096A patent/SG186289A1/en unknown
- 2011-06-20 CA CA2801076A patent/CA2801076C/en not_active Expired - Fee Related
- 2011-06-20 NZ NZ603881A patent/NZ603881A/en not_active IP Right Cessation
- 2011-06-20 BR BR112012032626A patent/BR112012032626A2/pt not_active Application Discontinuation
- 2011-06-20 MX MX2012015178A patent/MX2012015178A/es active IP Right Grant
- 2011-06-20 AU AU2011271228A patent/AU2011271228B2/en not_active Ceased
- 2011-06-20 JP JP2013516654A patent/JP5363683B2/ja active Active
- 2011-06-20 PH PH1/2012/502514A patent/PH12012502514A1/en unknown
- 2011-06-20 US US13/164,290 patent/US8449610B2/en active Active
- 2011-06-20 ES ES11729519.6T patent/ES2523387T3/es active Active
- 2011-06-20 RU RU2013102497/04A patent/RU2571091C2/ru not_active IP Right Cessation
- 2011-06-21 AR ARP110102145A patent/AR081963A1/es not_active Application Discontinuation
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2012
- 2012-12-06 IL IL223487A patent/IL223487A/en not_active IP Right Cessation
- 2012-12-10 ZA ZA2012/09331A patent/ZA201209331B/en unknown
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