JP2013529059A5 - - Google Patents

Download PDF

Info

Publication number
JP2013529059A5
JP2013529059A5 JP2012556526A JP2012556526A JP2013529059A5 JP 2013529059 A5 JP2013529059 A5 JP 2013529059A5 JP 2012556526 A JP2012556526 A JP 2012556526A JP 2012556526 A JP2012556526 A JP 2012556526A JP 2013529059 A5 JP2013529059 A5 JP 2013529059A5
Authority
JP
Japan
Prior art keywords
region
seq
sequence
antibody
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012556526A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013529059A (ja
JP6055312B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2011/053646 external-priority patent/WO2011110642A2/en
Publication of JP2013529059A publication Critical patent/JP2013529059A/ja
Publication of JP2013529059A5 publication Critical patent/JP2013529059A5/ja
Application granted granted Critical
Publication of JP6055312B2 publication Critical patent/JP6055312B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

JP2012556526A 2010-03-10 2011-03-10 Ｃ−ｍｅｔに対するモノクローナル抗体 Active JP6055312B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31262210P 2010-03-10 2010-03-10
US61/312,622 2010-03-10
DKPA201000191 2010-03-10
DKPA201000191 2010-03-10
DKPA201000862 2010-09-24
DKPA201000862 2010-09-24
PCT/EP2011/053646 WO2011110642A2 (en) 2010-03-10 2011-03-10 Monoclonal antibodies against c-met

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016121630A Division JP6348541B2 (ja) 2010-03-10 2016-06-20 Ｃ−ｍｅｔに対するモノクローナル抗体

Publications (3)

Publication Number Publication Date
JP2013529059A JP2013529059A (ja) 2013-07-18
JP2013529059A5 true JP2013529059A5 (OSRAM) 2014-04-24
JP6055312B2 JP6055312B2 (ja) 2017-01-11

Family

ID=44342987

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012556526A Active JP6055312B2 (ja) 2010-03-10 2011-03-10 Ｃ−ｍｅｔに対するモノクローナル抗体
JP2016121630A Active JP6348541B2 (ja) 2010-03-10 2016-06-20 Ｃ−ｍｅｔに対するモノクローナル抗体
JP2018104445A Active JP6697027B2 (ja) 2010-03-10 2018-05-31 Ｃ−ｍｅｔに対するモノクローナル抗体
JP2020076411A Active JP7034204B2 (ja) 2010-03-10 2020-04-23 Ｃ－ｍｅｔに対するモノクローナル抗体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016121630A Active JP6348541B2 (ja) 2010-03-10 2016-06-20 Ｃ−ｍｅｔに対するモノクローナル抗体
JP2018104445A Active JP6697027B2 (ja) 2010-03-10 2018-05-31 Ｃ−ｍｅｔに対するモノクローナル抗体
JP2020076411A Active JP7034204B2 (ja) 2010-03-10 2020-04-23 Ｃ－ｍｅｔに対するモノクローナル抗体

Country Status (26)

Country Link
US (6) US9068011B2 (OSRAM)
EP (4) EP3904391B1 (OSRAM)
JP (4) JP6055312B2 (OSRAM)
KR (2) KR101814571B1 (OSRAM)
CN (2) CN103003307B (OSRAM)
AU (4) AU2011226103C1 (OSRAM)
BR (1) BR112012022672B1 (OSRAM)
CA (3) CA3254586A1 (OSRAM)
DK (1) DK3904391T3 (OSRAM)
EA (1) EA201201273A1 (OSRAM)
ES (1) ES2993335T3 (OSRAM)
FI (1) FI3904391T3 (OSRAM)
HR (1) HRP20241246T1 (OSRAM)
HU (1) HUE068433T2 (OSRAM)
IL (1) IL221408B (OSRAM)
LT (1) LT3904391T (OSRAM)
MX (1) MX340295B (OSRAM)
NZ (1) NZ602294A (OSRAM)
PH (1) PH12012501793B1 (OSRAM)
PL (1) PL3904391T3 (OSRAM)
PT (1) PT3904391T (OSRAM)
RS (1) RS66008B1 (OSRAM)
SG (2) SG10201501767VA (OSRAM)
SI (1) SI3904391T1 (OSRAM)
SM (1) SMT202400403T1 (OSRAM)
WO (1) WO2011110642A2 (OSRAM)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS66008B1 (sr) 2010-03-10 2024-10-31 Genmab As Monoklonska antitela protiv c-met
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
WO2012042026A1 (en) 2010-09-30 2012-04-05 Ablynx Nv Biological materials related to c-met
NZ780183A (en) 2011-06-23 2024-12-20 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
EP2723771B1 (en) 2011-06-23 2019-09-11 Ablynx NV Serum albumin binding proteins
UA117901C2 (uk) 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
US9201074B2 (en) 2011-09-20 2015-12-01 Eli Lilly And Company Anti-c-Met antibodies
US9346884B2 (en) * 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
EP2747783B1 (en) * 2011-09-30 2017-06-14 Ablynx N.V. Biological materials related to c-met
KR20130037153A (ko) * 2011-10-05 2013-04-15 삼성전자주식회사 항 ｃ-Ｍｅｔ 항체 및 그의 용도
ES2749349T3 (es) * 2011-11-07 2020-03-19 Medimmune Llc Proteínas de unión multiespecíficas y multivalentes y usos de las mismas
AU2012340826A1 (en) 2011-11-21 2014-05-29 Genentech, Inc. Purification of anti-c-met antibodies
EP2785741A1 (en) * 2011-12-02 2014-10-08 Cancer Research Technology Limited Antibodies against hgf - receptor and uses
GB201121914D0 (en) 2011-12-20 2012-02-01 Ge Healthcare Ltd Method for patient selection
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9708601B2 (en) * 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
WO2013192594A2 (en) * 2012-06-21 2013-12-27 Sorrento Therapeutics Inc. Antigen binding proteins that bind c-met
CN104736174B (zh) 2012-07-06 2019-06-14 根马布私人有限公司 具有三重突变的二聚体蛋白质
EP3632462A1 (en) 2012-07-06 2020-04-08 Genmab B.V. Dimeric protein with triple mutations
PL2922872T3 (pl) * 2012-11-21 2019-03-29 Janssen Biotech, Inc. Bispecyficzne przeciwciała przeciwko egfr/c-met
US20170275367A1 (en) 2012-11-21 2017-09-28 Janssen Biotech, Inc. Bispecific EGFR/C-Met Antibodies
US9695228B2 (en) 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
KR20200024345A (ko) 2013-01-10 2020-03-06 젠맵 비. 브이 인간 IgG1 Fc 영역 변이체 및 그의 용도
JP2014157056A (ja) * 2013-02-15 2014-08-28 Fujirebio Inc ｃ−ＭＥＴ遺伝子増幅細胞の検出方法
MX2015011712A (es) 2013-03-06 2016-04-04 Merrimack Pharmaceuticals Inc Anticerpos biespecificos fc en fila anti-c-met.
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
EP2787008B1 (en) * 2013-04-02 2019-09-04 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-C-met antibody
US10214593B2 (en) 2013-04-02 2019-02-26 Samsung Electronics Co., Ltd. Anti-idiotype antibody against anti-c-MET antibody
IL244623B (en) 2013-10-14 2022-08-01 Janssen Biotech Inc Cysteine engineered fibronectin type iii domain binding molecules
EA039356B1 (ru) * 2013-10-18 2022-01-18 Янссен Байотек, Инк. БИСПЕЦИФИЧЕСКИЕ К EGFR/c-Met АНТИТЕЛА
US9717715B2 (en) 2013-11-15 2017-08-01 Samsung Electronics Co., Ltd. Method of combination therapy using an anti-C-Met antibody
DK3071237T3 (da) 2013-11-21 2024-09-09 Genmab As Lyofiliseret formulering af antistoflægemiddelkonjugat
CN105085680A (zh) * 2014-05-23 2015-11-25 复旦大学 人源化抗PD-1及c-MET双特异性抗体及其制备方法和应用
KR101615619B1 (ko) * 2014-08-07 2016-04-26 주식회사 파멥신 c-Met 특이적 인간 항체 및 그 제조방법
WO2016042412A1 (en) 2014-09-16 2016-03-24 Symphogen A/S Anti-met antibodies and compositions
JP6706617B2 (ja) 2014-11-06 2020-06-10 スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． 抗プロ／潜在型−ミオスタチン抗体およびその使用
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
IL303543A (en) 2015-02-18 2023-08-01 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
CN113106053A (zh) 2015-04-21 2021-07-13 恩立夫克治疗有限责任公司 治疗性汇集的血液凋亡细胞制剂与其用途
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
JP2018527903A (ja) * 2015-07-22 2018-09-27 スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． Ｇｄｆ１１結合タンパク質およびその使用
RS62330B1 (sr) 2015-09-15 2021-10-29 Scholar Rock Inc Antitela pro/latentnog miostatina i njihova upotreba
US11235063B2 (en) * 2015-11-03 2022-02-01 Merck Patent Gmbh Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof
US10287345B2 (en) 2016-01-08 2019-05-14 Scholar Rock, Inc. Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies
EP3416661A4 (en) 2016-02-18 2020-03-04 Enlivex Therapeutics Ltd. COMBINATION OF IMMUNOTHERAPY AND CYTOKINE CONTROL THERAPY FOR THE TREATMENT OF CANCER
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
KR20210082548A (ko) 2016-06-13 2021-07-05 스칼러 락, 인크. 미오스타틴 억제제의 용도 및 조합 요법
SG11201811062XA (en) 2016-06-21 2019-01-30 Janssen Biotech Inc Cysteine engineered fibronectin type iii domain binding molecules
WO2018026715A1 (en) 2016-08-02 2018-02-08 Vaccinex, Inc. Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
IL265645B2 (en) * 2016-09-29 2024-05-01 Mitsubishi Tanabe Pharma Corp Cmet monoclonal binding agents, drug conjugates thereof and uses thereof
TWI782930B (zh) * 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
JP7104703B2 (ja) 2016-12-14 2022-07-21 ヤンセン バイオテツク，インコーポレーテツド Ｃｄ８ａ結合フィブロネクチンｉｉｉ型ドメイン
EP3554561B1 (en) 2016-12-14 2023-06-28 Janssen Biotech, Inc. Cd137 binding fibronectin type iii domains
WO2018111976A1 (en) 2016-12-14 2018-06-21 Janssen Biotech, Inc. Pd-l1 binding fibronectin type iii domains
TW201825515A (zh) * 2017-01-04 2018-07-16 美商伊繆諾金公司 Ｍｅｔ抗體以及其免疫結合物及用途
SI3565592T1 (sl) 2017-01-06 2023-05-31 Scholar Rock, Inc. Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina
CN114989305A (zh) * 2017-03-31 2022-09-02 北京智仁美博生物科技有限公司 新型双特异性抗体及其用途
MX2019013517A (es) 2017-05-24 2020-08-17 Pandion Operations Inc Inmunotolerancia dirigida.
KR102078292B1 (ko) * 2017-05-30 2020-02-19 주식회사 종근당 신규한 항 c-Met 항체 및 이의 용도
US11525002B2 (en) 2017-10-11 2022-12-13 Board Of Regents, The University Of Texas System Human PD-L1 antibodies and methods of use therefor
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
TWI841554B (zh) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
EP4501355A3 (en) 2018-03-23 2025-04-30 Board Of Regents, The University Of Texas System Dual specificity antibodies to pd-l1 and pd-l2 and methods of use therefor
CN117586412A (zh) 2018-03-23 2024-02-23 得克萨斯州大学系统董事会 针对人pd-l1和pd-l2的双重特异性抗体及其使用方法
CN119101158A (zh) 2018-03-23 2024-12-10 得克萨斯州大学系统董事会 人pd-l2抗体及其使用方法
UA130009C2 (uk) 2018-05-07 2025-10-15 Генмаб А/С Спосіб лікування раку за допомогою комбінації антитіла до pd-1 і кон'югата антитіла до тканинного фактора і лікарського засобу
RU2768287C1 (ru) * 2018-07-10 2022-03-23 Генемедицине Ко., Лтд. Противоопухолевая композиция
TWI844571B (zh) 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
KR102396194B1 (ko) * 2018-12-07 2022-05-10 서울대학교 산학협력단 항 c-Met 아고니스트 항체 및 이의 용도
KR102433184B1 (ko) * 2018-12-07 2022-08-17 서울대학교 산학협력단 항 c-Met 아고니스트 항체 및 이의 용도
EP3972992A4 (en) 2019-05-20 2023-07-19 Pandion Operations, Inc. MADCAM TARGETED IMMUNOTLERANCE
AU2020318112C1 (en) * 2019-07-19 2024-09-26 Wuxi Xdc Singapore Private Limited Polypeptide complex for conjugation and use thereof
JP2022542431A (ja) 2019-07-30 2022-10-03 キューエルエスエフ バイオセラピューティクス， インコーポレイテッド 二重特異性抗ｌｒｒｃ１５及びｃｄ３イプシロン抗体
KR20220063185A (ko) 2019-09-16 2022-05-17 리제너론 파마슈티칼스 인코포레이티드 면역-pet 영상화를 위한 방사성 표지된 met 결합 단백질
EP4045061A4 (en) 2019-10-14 2024-04-17 ARO Biotherapeutics Company FIBRONECTIN TYPE III DOMAINS BINDING TO CD137
WO2021076543A1 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Epcam binding fibronectin type iii domains
WO2021076574A2 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Fn3 domain-sirna conjugates and uses thereof
CN111171147B (zh) * 2020-02-11 2021-07-20 北京康普美特创新医药科技有限责任公司 一种抗补体c3分子的全人源单克隆抗体及应用
WO2021168079A1 (en) 2020-02-21 2021-08-26 Pandion Operations, Inc. Tissue targeted immunotolerance with a cd39 effector
CN111620944B (zh) * 2020-06-01 2023-03-21 长春师范大学 一种全人源化抗乙肝病毒单克隆抗体、制备方法及其应用
CN112521507B (zh) * 2020-08-10 2021-06-08 北京鼎成肽源生物技术有限公司 抗人c-Met人鼠嵌合单克隆抗体及其应用
CN118221804B (zh) * 2021-01-18 2025-02-07 上海药明合联生物技术有限公司 工程化抗体和包含工程化抗体的抗体-药物偶联物
BR112023021318A2 (pt) 2021-04-14 2023-12-19 Aro Biotherapeutics Company Conjugados de domínio fn3-sirna e usos dos mesmos
JP2024517610A (ja) 2021-04-14 2024-04-23 アロ・バイオセラピューティクス・カンパニー Ｃｄ７１に結合するフィブロネクチンｉｉｉ型ドメイン
KR20240026985A (ko) * 2021-06-25 2024-02-29 아카데미아 시니카 상피 세포 부착 분자(epcam) 억제제 및 간세포 성장 인자 수용체(hgfr) 억제제와의 조합된 암 요법
CN113621058B (zh) * 2021-08-19 2023-05-23 中国科学院微生物研究所 黄热病毒抗体及其应用
CA3230934A1 (en) * 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-cmet antibodies and their uses
CN116178530A (zh) * 2021-09-26 2023-05-30 上海君实生物医药科技股份有限公司 抗体在治疗SARS-CoV-2感染的用途
CN116725960A (zh) * 2022-03-11 2023-09-12 上海君实生物医药科技股份有限公司 新型冠状病毒抗体药物组合物及其用途
IL315910A (en) 2022-04-02 2024-11-01 Biotheus Inc Monoclonal antibodies and bispecific antibody against c-Met
MA71625A (fr) 2022-07-30 2025-05-30 Pinetree Therapeutics, Inc. Compositions pour la dégradation lysosomale ciblée et leurs procédés d'utilisation
KR20250122524A (ko) 2022-12-22 2025-08-13 스칼러 락, 인크. 미오스타틴 활성화의 선택적이고 강력한 억제 항체
TW202430570A (zh) * 2023-01-19 2024-08-01 英屬開曼群島商百濟神州有限公司 抗cmet抗體及使用方法
WO2024258870A2 (en) 2023-06-12 2024-12-19 Amgen Inc. Lymphotoxin beta receptor agonist binding proteins

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US835A (en) 1838-07-12 X i i i x
US6077A (en) 1849-01-30 Improved hinged claw-wrench
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5648273A (en) 1989-12-27 1997-07-15 The United States Of America, As Represented By The Department Of Health And Human Services Hepatic growth factor receptor is the MET proto-oncogene
US5362716A (en) 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
JPH05504476A (ja) 1989-12-27 1993-07-15 アメリカ合衆国 ヒト胃癌検出用診断プローブ
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69133349T2 (de) 1990-09-14 2004-10-07 Us Health Ein nicht-mitogener kompetitiver hgf-antagonist
US6566098B1 (en) 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
WO1992022645A1 (en) 1991-06-14 1992-12-23 Genpharm International, Inc. Transgenic immunodeficient non-human animals
JPH06508880A (ja) 1991-07-08 1994-10-06 ユニバーシティ　オブ　マサチューセッツ　アット　アムハースト サーモトロピック液晶セグメント化ブロックコポリマー
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1994000764A1 (en) 1992-06-26 1994-01-06 THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES The met proto-oncogene and a method for predicting breast cancer progression
WO1994006909A2 (en) 1992-09-18 1994-03-31 United States Of America, As Represented By The Secretary, Department Of Health And Human Services A method of preventing tumor metastasis
US5361922A (en) 1993-04-02 1994-11-08 Beckman Instruments, Inc. Centrifuge tubes with snap plugs
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
US5646036A (en) 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
US6214344B1 (en) 1995-06-02 2001-04-10 Genetech, Inc. Hepatocyte growth factor receptor antagonists and uses thereof
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
CA2347067C (en) 1998-03-31 2013-09-17 Geron Corporation Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer
MXPA01007895A (es) 1999-02-03 2003-07-21 Biosante Pharmaceuticals Inc Particulas terapeuticas de fosfato de calcio, metodos de manufactura y usos.
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
HK1049014A1 (zh) 1999-07-29 2003-04-25 Medarex, Inc. 抗her2/neu的人类单克隆抗体
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
EP1355921A2 (en) 2000-06-29 2003-10-29 North Shore-Long Island Jewish Health System Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof
AU2002235141A1 (en) 2000-11-27 2002-06-03 Geron Corporation Glycosyltransferase vectors for treating cancer
DK1354034T3 (da) 2000-11-30 2008-03-25 Medarex Inc Transgene transchromosomale gnavere til fremstilling af humane antistoffer
IL159177A0 (en) 2001-06-20 2004-06-01 Prochon Biotech Ltd Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
AU2002351208A1 (en) 2001-12-03 2003-06-17 Abgenix, Inc. Antibodies against carbonic anhydrase IX (CA IX) tumor antigen
CA2472383A1 (en) 2001-12-27 2003-07-17 Van Andel Research Institute Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor
CA2476625A1 (en) 2002-02-20 2003-08-28 Dyax Corp. Mhc-peptide complex binding ligands
BRPI0407446A (pt) 2003-02-13 2006-01-31 Pharmacia Corp Anticorpos para c-met para o tratamento de cânceres
ITMI20031127A1 (it) 2003-06-05 2004-12-06 Uni Degli Studi Del Piemont E Orientale Am Anticorpi anti-hgf-r e loro uso
EP2367008A3 (en) 2003-06-06 2014-12-24 Genentech, Inc. Modulating the interaction between HGF beta chain and C-Met
HN2004000285A (es) 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
KR100556660B1 (ko) 2003-11-11 2006-03-10 국립암센터 Ｈｇｆ의 중화가능 에피토프 및 이에 결합하는 중화 항체
ZA200604620B (en) 2003-12-10 2007-10-31 Medarex Inc IP-10 antibodies and their uses
RU2006124743A (ru) 2003-12-11 2008-01-20 Дженентек, Инк. (Us) СПОСОБЫ И КОМПОЗИЦИИ ДЛЯ ИНГИБИРОВАНИЯ ДИМЕРИЗАЦИИ И АКТИВАЦИИ с-Мет
WO2005063816A2 (en) 2003-12-19 2005-07-14 Genentech, Inc. Monovalent antibody fragments useful as therapeutics
HRP20110320T1 (hr) 2004-05-27 2011-05-31 Crucell Holland B.V. Molekule za vezanje koje mogu neutralizirati virus bjesnoće i njihova uporaba
US7476724B2 (en) 2004-08-05 2009-01-13 Genentech, Inc. Humanized anti-cmet antibodies
EP1810979B1 (en) 2004-09-22 2012-06-20 Kyowa Hakko Kirin Co., Ltd. STABILIZED HUMAN IgG4 ANTIBODIES
EP1868648B1 (en) 2005-03-25 2015-04-15 Genentech, Inc. Methods and compositions for modulating hyperstabilized c-met
KR20140068234A (ko) 2005-03-31 2014-06-05 더 제너럴 하스피탈 코포레이션 Ｈｇｆ／ｈｇｆｒ 활성의 모니터링 및 조정
AR056142A1 (es) 2005-10-21 2007-09-19 Amgen Inc Metodos para generar el anticuerpo igg monovalente
US10155816B2 (en) 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
KR101429297B1 (ko) * 2006-02-06 2014-08-12 메테레시스 트랜스레이셔날 리서치 에스.에이. 종양 치료를 위한 항-Ｍｅｔ 단클론 항체, 이의 단편과벡터 및 상응하는 산물
TW200815470A (en) 2006-03-30 2008-04-01 Novartis Ag Compositions and methods of use for antibodies of c-Met
AR059922A1 (es) 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
DK2457928T3 (en) * 2007-03-13 2017-08-28 Univ Zuerich Monoclonal human tumor-specific antibody
WO2008145142A1 (en) 2007-05-31 2008-12-04 Genmab A/S Stable igg4 antibodies
WO2008145137A2 (en) * 2007-05-31 2008-12-04 Genmab A/S Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering
US20080300108A1 (en) 2007-05-31 2008-12-04 Eybergen William N Torque transfer device and system
EP2014681A1 (en) 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
US9693539B2 (en) 2007-08-10 2017-07-04 E. R. Squibb & Sons, L.L.C. HCO32 and HCO27 and related examples
JP2011513427A (ja) * 2008-03-06 2011-04-28 ジェネンテック， インコーポレイテッド ｃ−ｍｅｔ及びＥＧＦＲアンタゴニストの併用療法
CN102076865B (zh) 2008-05-02 2016-03-16 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
US8455623B2 (en) 2008-05-21 2013-06-04 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
BRPI0919840B1 (pt) 2008-10-01 2023-02-28 Amgen Research (Munich) Gmbh Molécula de anticorpo de cadeia única biespecífica, seu uso, e composição farmacêutica que a compreende
PA8849001A1 (es) 2008-11-21 2010-06-28 Lilly Co Eli Anticuerpos de c-met
AR074438A1 (es) 2008-12-02 2011-01-19 Pf Medicament Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal
WO2010064090A1 (en) 2008-12-02 2010-06-10 Pierre Fabre Medicament Process for the modulation of the antagonistic activity of a monoclonal antibody
AR074439A1 (es) 2008-12-02 2011-01-19 Pf Medicament Anticuerpo anti-cmet (receptor c-met)
WO2010064089A1 (en) 2008-12-02 2010-06-10 Pierre Fabre Medicament Novel anti-cmet antibody
RS66008B1 (sr) 2010-03-10 2024-10-31 Genmab As Monoklonska antitela protiv c-met
PL2922872T3 (pl) * 2012-11-21 2019-03-29 Janssen Biotech, Inc. Bispecyficzne przeciwciała przeciwko egfr/c-met
US20170275367A1 (en) 2012-11-21 2017-09-28 Janssen Biotech, Inc. Bispecific EGFR/C-Met Antibodies

Similar Documents

Publication Publication Date Title
JP2013529059A5 (OSRAM)
JP7118117B2 (ja) 抗体－薬物コンジュゲートの選択的製造方法
CN105968206B (zh) 抗erbb3抗体
KR102408356B1 (ko) 항―axl 항체
CN102421802B (zh) 人源化的axl抗体
JP2020501531A5 (OSRAM)
JP2018503380A5 (OSRAM)
JP2018510617A5 (OSRAM)
CN107735093A (zh) Cd123抗体和其结合物
JP2020502233A5 (OSRAM)
JPWO2021139777A5 (OSRAM)
EP2603527A1 (en) Humanized egfr antibodies
KR20230132544A (ko) 신규한 항-그렘린1 항체
JP2025134713A (ja) Ｐｄ１およびｖｅｇｆｒ２二重結合剤
CA3092526A1 (en) Anti c-met antibodies
US10975165B2 (en) De-immunised anti-ERBB3 antibodies
CA3092169A1 (en) Pd1 binding agents
JP2023516195A (ja) Ｃ１９ ｃ３８二特異性抗体
WO2021173844A1 (en) C19 c38 bispecific antibodies
CN114502595A (zh) 针对脊髓灰质炎病毒受体(pvr)的抗体及其用途
JP2008526256A5 (OSRAM)
CN118076387A (zh) 靶向表达cdh17的肿瘤的多特异性抗体及其制备和使用方法
JP2024517760A (ja) 抗５ｔ４抗体及びその使用
CA3091307A1 (en) Csf1r binding agents
WO2021058735A1 (en) Cancer treatment with anti-met antibody compositions