JP2013527761A - 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法 - Google Patents

治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法 Download PDF

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JP2013527761A
JP2013527761A JP2013508500A JP2013508500A JP2013527761A JP 2013527761 A JP2013527761 A JP 2013527761A JP 2013508500 A JP2013508500 A JP 2013508500A JP 2013508500 A JP2013508500 A JP 2013508500A JP 2013527761 A JP2013527761 A JP 2013527761A
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lrp6
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コン・フェン
セス・エッテンバーグ
デイビッド・ジェンキンズ
レイ・ミン
アンドレアス・レーヴ
カレン・ビンセント
リ・ヂョウ
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ノバルティス アーゲー
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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JP2013508500A 2010-05-06 2011-05-05 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法 Withdrawn JP2013527761A (ja)

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US33199310P 2010-05-06 2010-05-06
US61/331,993 2010-05-06
PCT/EP2011/057200 WO2011138391A1 (en) 2010-05-06 2011-05-05 Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies

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JP2013508500A Withdrawn JP2013527761A (ja) 2010-05-06 2011-05-05 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法
JP2017157638A Expired - Fee Related JP6678627B2 (ja) 2010-05-06 2017-08-17 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法
JP2019216739A Pending JP2020063262A (ja) 2010-05-06 2019-11-29 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法
JP2023145259A Pending JP2023182590A (ja) 2010-05-06 2023-09-07 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法

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JP2019216739A Pending JP2020063262A (ja) 2010-05-06 2019-11-29 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法
JP2023145259A Pending JP2023182590A (ja) 2010-05-06 2023-09-07 治療的低密度リポタンパク質関連タンパク質６（ｌｒｐ６）多価抗体の組成物および使用方法

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KR (1) KR20130066631A (enExample)
CN (1) CN103237811A (enExample)
AU (1) AU2011249782B2 (enExample)
BR (1) BR112012028326A2 (enExample)
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JP2019506841A (ja) * 2015-12-04 2019-03-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 腫瘍細胞においてｗｎｔシグナル伝達に拮抗する二重パラトピックポリペプチド
CN111699003A (zh) * 2017-12-19 2020-09-22 瑟罗泽恩公司 抗lrp5/6抗体和使用方法
JP2023526527A (ja) * 2020-05-19 2023-06-21 モメンタ ファーマシューティカルズ インコーポレイテッド 高シアル化ＩｇＧの調製及び精製
US11773171B2 (en) 2017-12-19 2023-10-03 Surrozen Operating, Inc. WNT surrogate molecules and uses thereof
US12006368B2 (en) 2017-12-19 2024-06-11 Surrozen Operating, Inc. Anti-frizzled antibodies and methods of use

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AR080795A1 (es) 2010-03-24 2012-05-09 Genentech Inc Anticuerpos anti-lrp6 (proteina relacionada con el receptor ldl tipo 6)
CA2798432A1 (en) 2010-05-06 2011-11-10 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies
PH12012502193A1 (en) 2010-05-06 2021-08-09 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies
UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
UY33826A (es) * 2010-12-22 2012-07-31 Abbott Lab Proteínas de unión con dominios trivariables y sus usos
AU2012332263A1 (en) * 2011-11-04 2014-05-22 Novartis Ag Low density lipoprotein-related protein 6 (LRP6) - half life extender constructs
WO2014029752A1 (en) * 2012-08-22 2014-02-27 Glaxo Group Limited Anti lrp6 antibodies
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
WO2016007775A1 (en) 2014-07-11 2016-01-14 Genentech, Inc. Notch pathway inhibition
EP4219564A1 (en) 2014-09-12 2023-08-02 The Board of Trustees of the Leland Stanford Junior University Wnt signaling agonist molecules
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CN105349495B (zh) * 2015-11-17 2019-02-22 清华大学 抗凝血因子ix单克隆抗体的杂交瘤细胞株
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
ES2909833T3 (es) 2016-05-11 2022-05-10 Cytiva Bioprocess R & D Ab Método de limpieza y/o desinfección de una matriz de separación
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10513537B2 (en) 2016-05-11 2019-12-24 Ge Healthcare Bioprocess R&D Ab Separation matrix
US11708390B2 (en) 2016-05-11 2023-07-25 Cytiva Bioprocess R&D Ab Method of storing a separation matrix
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
US11702480B2 (en) 2016-11-18 2023-07-18 The Regents Of The University Of California Engineered antibodies and uses thereof
AR111840A1 (es) 2017-05-31 2019-08-21 Boehringer Ingelheim Int Polipéptidos que antagonizan la señalización wnt en células tumorales
IL277095B2 (en) * 2018-03-07 2025-10-01 Pfizer Preparations containing anti-PD-1 antibody
WO2020080941A1 (en) * 2018-10-16 2020-04-23 Umc Utrecht Holding B.V. Anti- low-density lipoprotein receptor-related protein 5/6 antibodies
EP3911682A4 (en) * 2019-01-14 2023-03-15 The Regents of the University of California COMPOSITIONS AND METHODS TO MODULATE CELLULAR INTERNALIZATION
WO2020200998A1 (en) * 2019-03-29 2020-10-08 Boehringer Ingelheim International Gmbh Anticancer combination therapy
KR102504884B1 (ko) * 2019-07-23 2023-02-28 와이-클론 메디컬 사이언시스 컴퍼니 리미티드 Sftsv에 결합 가능한 나노 항체 및 이의 응용
WO2021026666A1 (en) * 2019-08-14 2021-02-18 Modmab Therapeutics Inc. Antibodies that bind to lrp6 proteins and methods of use
US20240254219A1 (en) * 2021-09-20 2024-08-01 The Regents Of The University Of California Novel wnt agonist antibodies and therapeutic uses thereof
CN115124618B (zh) * 2022-06-24 2023-04-18 复星凯特生物科技有限公司 一种自体血液分离的免疫细胞在治疗疾病中的应用

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