JP2013524837A5 - - Google Patents
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- JP2013524837A5 JP2013524837A5 JP2013508153A JP2013508153A JP2013524837A5 JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5 JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- reprogramming
- poly
- postnatal
- genetically modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000008672 reprogramming Effects 0.000 claims 17
- 210000002950 fibroblast Anatomy 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 210000004413 cardiac myocyte Anatomy 0.000 claims 8
- 101150107475 MEF2C gene Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 101150003286 gata4 gene Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 101150115978 tbx5 gene Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 101001053263 Homo sapiens Insulin gene enhancer protein ISL-1 Proteins 0.000 claims 4
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims 4
- 101150078445 MYOCD gene Proteins 0.000 claims 4
- -1 Mesp1 Proteins 0.000 claims 4
- 101150114527 Nkx2-5 gene Proteins 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- 102000007547 Laminin Human genes 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 241000283984 Rodentia Species 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 108700029229 Transcriptional Regulatory Elements Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 229960005188 collagen Drugs 0.000 claims 2
- 238000005138 cryopreservation Methods 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229940014259 gelatin Drugs 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 235000019426 modified starch Nutrition 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32898810P | 2010-04-28 | 2010-04-28 | |
| US61/328,988 | 2010-04-28 | ||
| US36429510P | 2010-07-14 | 2010-07-14 | |
| US61/364,295 | 2010-07-14 | ||
| PCT/US2011/033938 WO2011139688A2 (en) | 2010-04-28 | 2011-04-26 | Methods for generating cardiomyocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524837A JP2013524837A (ja) | 2013-06-20 |
| JP2013524837A5 true JP2013524837A5 (cg-RX-API-DMAC7.html) | 2015-05-28 |
| JP5988961B2 JP5988961B2 (ja) | 2016-09-07 |
Family
ID=44904333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508153A Active JP5988961B2 (ja) | 2010-04-28 | 2011-04-26 | 心筋細胞を発生させるための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9517250B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2563907B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5988961B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011139688A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US11769398B2 (en) | 2005-09-08 | 2023-09-26 | Universal Electronics Inc. | System and method for widget-assisted setup of a universal remote control |
| US7907222B2 (en) | 2005-09-08 | 2011-03-15 | Universal Electronics Inc. | System and method for simplified setup of a universal remote control |
| US9852615B2 (en) | 2011-03-25 | 2017-12-26 | Universal Electronics Inc. | System and method for facilitating appliance control via a smart device |
| JP5988961B2 (ja) | 2010-04-28 | 2016-09-07 | ザ ジェイ． デヴィッド グラッドストーン インスティテューツ | 心筋細胞を発生させるための方法 |
| EP2585592A4 (en) * | 2010-06-23 | 2013-08-21 | Vivoscript Inc | COMPOSITIONS AND METHODS FOR RENEWING CELLS WITHOUT GENETIC MODIFICATION FOR THE TREATMENT OF CARDIOVASCULAR DISEASES |
| AU2012220702B2 (en) * | 2011-02-22 | 2016-12-15 | The Board Of Regents Of The University Of Texas System | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| JP6113160B2 (ja) * | 2011-07-19 | 2017-04-12 | ヴィヴォスクリプト，インコーポレイテッド | 軟骨損傷を修復するために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| WO2013033213A1 (en) | 2011-08-30 | 2013-03-07 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| US9019435B2 (en) | 2011-09-22 | 2015-04-28 | Universal Electronics Inc. | System and method for configuring controlling device functionality |
| US11756412B2 (en) | 2011-10-28 | 2023-09-12 | Universal Electronics Inc. | Systems and methods for associating services and/or devices with a voice assistant |
| US9449500B2 (en) | 2012-08-08 | 2016-09-20 | Universal Electronics Inc. | System and method for optimized appliance control |
| US11295603B2 (en) | 2011-10-28 | 2022-04-05 | Universal Electronics Inc. | System and method for optimized appliance control |
| US10593195B2 (en) | 2011-10-28 | 2020-03-17 | Universal Electronics Inc. | System and method for optimized appliance control |
| US10937308B2 (en) | 2011-10-28 | 2021-03-02 | Universal Electronics Inc. | System and method for optimized appliance control |
| EP3446716B1 (en) | 2011-11-09 | 2020-03-18 | Cedars-Sinai Medical Center | Transcription factor-based generation of pacemaker cells and methods of using same |
| JP2013240308A (ja) * | 2012-05-23 | 2013-12-05 | Kagoshima Univ | ヒトＥＳ／ｉＰＳ細胞における遺伝子発現方法 |
| WO2014028493A2 (en) | 2012-08-13 | 2014-02-20 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| WO2014071323A2 (en) * | 2012-11-02 | 2014-05-08 | Duke University | Inhibition of histone methyltransferase for cardiac reprogramming |
| EP2914114B1 (en) * | 2012-11-02 | 2017-10-04 | Cornell University | Angiogenic conditioning to enhance cardiac cellular reprogramming of fibroblasts of the infarcted myocardium |
| WO2015061568A1 (en) | 2013-10-23 | 2015-04-30 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Reprogramming cardiomyocytes with one transcription factor |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| DE102013114671B4 (de) * | 2013-12-20 | 2015-10-29 | Universität Rostock | Verfahren zur Erzeugung von Sinusknotenzellen ("Herz-Schrittmacherzellen") aus Stammzellen |
| JP2015213441A (ja) * | 2014-05-08 | 2015-12-03 | 学校法人慶應義塾 | 心筋様細胞の作製方法及びそれに用いる培地 |
| US10760040B1 (en) | 2014-07-03 | 2020-09-01 | NanoCav, LLC | Mechanical transfection devices and methods |
| US10081816B1 (en) * | 2014-07-03 | 2018-09-25 | Nant Holdings Ip, Llc | Mechanical transfection devices and methods |
| EP3200808B1 (en) | 2014-10-03 | 2024-07-31 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2016056438A1 (ja) * | 2014-10-06 | 2016-04-14 | 学校法人 慶應義塾 | 心筋様細胞の作製方法及びそれに用いる心筋様細胞の作製用組成物 |
| EP3259346B1 (en) * | 2015-02-20 | 2024-08-07 | Baylor College of Medicine | P63 inactivation for the treatment of heart failure |
| CN118340951A (zh) * | 2015-03-12 | 2024-07-16 | 株式会社艾迪科 | 使用脱细胞化组织的抗粘连材料和代用生物膜 |
| US11253551B2 (en) | 2016-01-11 | 2022-02-22 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017151717A1 (en) * | 2016-03-01 | 2017-09-08 | French Brent A | Compositions and methods for adeno-associated virus mediated gene expression in myofibroblast-like cells |
| CN109072220A (zh) * | 2016-03-15 | 2018-12-21 | 学校法人庆应义塾 | 由成纤维细胞直接制造心脏祖细胞和心肌细胞的方法 |
| CA3019570A1 (en) * | 2016-03-30 | 2017-10-05 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Enhanced direct cardiac reprogramming |
| US11433116B2 (en) | 2016-04-14 | 2022-09-06 | Cedars-Sinai Medical Center | GJA1 isoforms protect against metabolic stress |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| JP2019520074A (ja) * | 2016-06-27 | 2019-07-18 | ザ ジェイ． デビッド グラッドストーン インスティテューツ、 ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デビッド グラッドストーン | 操作された心筋細胞およびその使用 |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| WO2018055235A1 (en) | 2016-09-21 | 2018-03-29 | University Of Helsinki | Isoxazole-amides for treating cardiac diseases |
| EP3612191A4 (en) | 2017-04-19 | 2020-12-30 | Cedars-Sinai Medical Center | METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY |
| WO2018232458A1 (en) * | 2017-06-21 | 2018-12-27 | Cell Mogrify Limited | Cell reprogramming to cardiomyocytes |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| EP3747993A4 (en) * | 2018-01-30 | 2021-11-24 | Kataoka Corporation | CARDIOMYOCYTE PRODUCTION PROCESS |
| WO2019152549A1 (en) | 2018-02-05 | 2019-08-08 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and y-rnas |
| KR20210102870A (ko) | 2018-08-30 | 2021-08-20 | 테나야 테라퓨틱스, 인코포레이티드 | 미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍 |
| JP7630176B2 (ja) | 2019-04-01 | 2025-02-17 | テナヤ セラピューティクス， インコーポレイテッド | 操作されたカプシドを有するアデノ随伴ウイルス |
| EP3965800A4 (en) * | 2019-05-08 | 2023-02-15 | Cedars-Sinai Medical Center | Therapeutically active cells and exosomes |
| EP3980037A4 (en) * | 2019-06-06 | 2023-06-21 | President and Fellows of Harvard College | Cardiomyocytes and compositions and methods for producing the same |
| EP4028023A4 (en) * | 2019-09-11 | 2023-10-04 | Icahn School of Medicine at Mount Sinai | COMPOSITIONS COMPRISING MODIFIED RNA MOLECULES AND METHODS OF USE THEREOF |
| WO2021112115A1 (ja) * | 2019-12-03 | 2021-06-10 | 学校法人自治医科大学 | 心筋細胞の成熟方法、心筋細胞の成熟度評価方法、成熟心筋細胞の純化方法、創薬支援方法、心疾患の治療方法、成熟心筋細胞マーカー、レポーター細胞、成熟心筋細胞、心筋細胞成熟度評価装置、心筋細胞成熟度評価プログラム、心筋細胞成熟キット、及び心筋細胞純化キット |
| CN113046308A (zh) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法 |
| EP4508062A1 (en) | 2022-04-11 | 2025-02-19 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| JPWO2024150735A1 (cg-RX-API-DMAC7.html) * | 2023-01-10 | 2024-07-18 | ||
| WO2025129079A1 (en) * | 2023-12-13 | 2025-06-19 | Tenaya Therapeutics, Inc. | Cardiac-specific promoters for gene therapy |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5591624A (en) | 1988-03-21 | 1997-01-07 | Chiron Viagene, Inc. | Retroviral packaging cell lines |
| US7070994B2 (en) | 1988-03-21 | 2006-07-04 | Oxford Biomedica (Uk) Ltd. | Packaging cells |
| DE3829752A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
| DE3829766A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
| WO1990002806A1 (en) | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| US5817491A (en) | 1990-09-21 | 1998-10-06 | The Regents Of The University Of California | VSV G pseusdotyped retroviral vectors |
| ATE156344T1 (de) | 1991-04-25 | 1997-08-15 | Univ Brown Res Found | Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte |
| ES2197145T3 (es) | 1991-08-20 | 2004-01-01 | The Government Of The Usa As Represented By The Secretary Of The Deptm. Of Health And Human Services | Transferencia de genes mediada por adenovirus al gastrointestinal. |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| JPH08503855A (ja) | 1992-12-03 | 1996-04-30 | ジェンザイム・コーポレイション | 嚢胞性線維症に対する遺伝子治療 |
| US5834256A (en) | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
| AU687829B2 (en) | 1993-06-24 | 1998-03-05 | Advec, Inc. | Adenovirus vectors for gene therapy |
| EP1179350A3 (en) | 1993-08-12 | 2003-01-02 | Cytotherapeutics, Inc. | Encapsulated cell system for implantation into the human CNS |
| HU223733B1 (hu) | 1993-10-25 | 2004-12-28 | Canji, Inc. | Rekombináns adenovírus vektor és eljárás alkalmazására |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US6013517A (en) | 1994-05-09 | 2000-01-11 | Chiron Corporation | Crossless retroviral vectors |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| JPH11514857A (ja) | 1995-09-20 | 1999-12-21 | メルク エンド カンパニー インコーポレーテッド | 抗原虫剤の標的としてのヒストンデアセチラーゼ |
| FR2751345B1 (fr) | 1996-07-16 | 1998-09-18 | Univ Paris Curie | Lignees d'encapsidation hautement productrices |
| US7078387B1 (en) | 1998-12-28 | 2006-07-18 | Arch Development Corp. | Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors |
| EP1186655B1 (en) | 1999-06-01 | 2008-04-09 | Chugai Seiyaku Kabushiki Kaisha | Packaging cell |
| ATE324321T1 (de) | 2000-08-31 | 2006-05-15 | Edwin Lundgren | Steuervorrichtung für einen lenkdrachen an einem boot |
| US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
| US7425448B2 (en) | 2001-07-12 | 2008-09-16 | Geron Corporation | Cardiomyocyte precursors from human embryonic stem cells |
| WO2004094610A2 (en) * | 2003-04-21 | 2004-11-04 | Baylor College Of Medicine | Wnt as a factor for cardiac myogenesis |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US7695731B2 (en) | 2004-03-22 | 2010-04-13 | Cordis Corporation | Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury |
| US20090275032A1 (en) | 2005-08-01 | 2009-11-05 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through use of an HDAC modulator |
| US7620013B2 (en) * | 2005-12-21 | 2009-11-17 | Broadcom Corporation | Method and system for decoding control channels using repetition redundancy |
| US20100135970A1 (en) | 2006-10-27 | 2010-06-03 | Caritas St. Elizabeth Medical Center Of Boston, In | Methods for Reprogramming Adult Somatic Cells and Uses Thereof |
| US20100172883A1 (en) * | 2007-01-19 | 2010-07-08 | Bruneau Benoit Gaetan | Methods of generating cardiomyocytes |
| AU2008261550A1 (en) * | 2007-06-14 | 2008-12-18 | Cytomatrix Pty Ltd | Method of initiating cardiomyocyte differentiation |
| US20090081170A1 (en) * | 2007-09-13 | 2009-03-26 | Paul Riley | Cardiac progenitor cells |
| JP5558097B2 (ja) | 2007-12-10 | 2014-07-23 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| US8062346B2 (en) | 2007-12-21 | 2011-11-22 | Boston Scientific Scimed, Inc. | Flexible stent-graft device having patterned polymeric coverings |
| US20090208465A1 (en) | 2008-02-15 | 2009-08-20 | Keio University | Method of treating neural defects |
| CN102083982A (zh) | 2008-04-07 | 2011-06-01 | 纽珀滕索有限公司 | 通过rna干扰引入复能基因而重编程细胞 |
| WO2009136867A1 (en) | 2008-05-06 | 2009-11-12 | Agency For Science, Technology And Research | Method of effecting de-differentiation of a cell |
| EP2297332A4 (en) | 2008-06-13 | 2012-03-21 | Univ Kyoto | METHOD AND PLATFORMS FOR THE DRUG DISCOVERY |
| US20100150879A1 (en) * | 2008-10-16 | 2010-06-17 | Wary Kishore K | Methods for the detection, isolation, and use of lipid phosphate phosphatase-3-positive stem cells |
| WO2010124143A1 (en) | 2009-04-23 | 2010-10-28 | Nevada Cancer Institute | Reprogramming of somatic cells with purified proteins |
| US20100330044A1 (en) | 2009-06-30 | 2010-12-30 | Universite Libre De Bruxelles | Mesp1 as a master regulator of multipotent cardiovascular progenitor specification and uses thereof |
| ES2533581T3 (es) | 2010-03-05 | 2015-04-13 | Texas Heart Institute | ETS2 y Mesp1 generadores de progenitores cardíacos a partir de fibroblastos |
| JP5988961B2 (ja) | 2010-04-28 | 2016-09-07 | ザ ジェイ． デヴィッド グラッドストーン インスティテューツ | 心筋細胞を発生させるための方法 |
| EP2585592A4 (en) * | 2010-06-23 | 2013-08-21 | Vivoscript Inc | COMPOSITIONS AND METHODS FOR RENEWING CELLS WITHOUT GENETIC MODIFICATION FOR THE TREATMENT OF CARDIOVASCULAR DISEASES |
| WO2013033213A1 (en) | 2011-08-30 | 2013-03-07 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
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2011
- 2011-04-26 JP JP2013508153A patent/JP5988961B2/ja active Active
- 2011-04-26 WO PCT/US2011/033938 patent/WO2011139688A2/en not_active Ceased
- 2011-04-26 EP EP11777910.8A patent/EP2563907B1/en active Active
- 2011-04-26 US US13/642,391 patent/US9517250B2/en active Active
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2014
- 2014-03-19 US US14/219,541 patent/US9517251B2/en active Active
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