JP2013520512A5 - - Google Patents
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- Publication number
- JP2013520512A5 JP2013520512A5 JP2012555105A JP2012555105A JP2013520512A5 JP 2013520512 A5 JP2013520512 A5 JP 2013520512A5 JP 2012555105 A JP2012555105 A JP 2012555105A JP 2012555105 A JP2012555105 A JP 2012555105A JP 2013520512 A5 JP2013520512 A5 JP 2013520512A5
- Authority
- JP
- Japan
- Prior art keywords
- peg
- concentration
- molar excess
- fold molar
- mal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 13
- 108010031004 PEG-hemoglobin Proteins 0.000 claims 7
- 239000003085 diluting agent Substances 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 108010054147 Hemoglobins Proteins 0.000 claims 3
- 102000001554 Hemoglobins Human genes 0.000 claims 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- 125000006353 oxyethylene group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30823810P | 2010-02-25 | 2010-02-25 | |
| US61/308,238 | 2010-02-25 | ||
| PCT/US2011/025888 WO2011106396A1 (en) | 2010-02-25 | 2011-02-23 | Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520512A JP2013520512A (ja) | 2013-06-06 |
| JP2013520512A5 true JP2013520512A5 (enExample) | 2013-07-18 |
Family
ID=44507180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555105A Pending JP2013520512A (ja) | 2010-02-25 | 2011-02-23 | 低い反応成分比を用いて、ｐｅｇ−ヘモグロビン結合体を調製するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9493616B2 (enExample) |
| EP (1) | EP2539715B1 (enExample) |
| JP (1) | JP2013520512A (enExample) |
| KR (1) | KR20130067243A (enExample) |
| CN (1) | CN102859364A (enExample) |
| AU (2) | AU2011220885A1 (enExample) |
| CA (1) | CA2791122C (enExample) |
| WO (1) | WO2011106396A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013240141B2 (en) * | 2012-03-29 | 2017-11-02 | Sangart, Inc. | Diaspirin crosslinked PEGgylated hemoglobin |
| CA2908238C (en) * | 2012-04-03 | 2023-01-10 | Schindler, William | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
| JP7387597B2 (ja) | 2017-07-18 | 2023-11-28 | ヴァーテック・バイオ・インコーポレイテッド | ヘモグロビンを含む代用血液及び作製方法 |
| WO2022184005A1 (en) | 2021-03-01 | 2022-09-09 | Billion King International Limited | Thiosuccinyl-crosslinked hemoglobin conjugates and methods of use and preparation thereof |
| WO2023091642A1 (en) * | 2021-11-18 | 2023-05-25 | Virginia Commonwealth University | Modular field-stable bio-artificial blood substitute |
| WO2025219465A1 (en) * | 2024-04-19 | 2025-10-23 | Danmarks Tekniske Universitet | Hemoglobin-based oxygen carrier |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2161086B2 (de) | 1971-12-09 | 1975-04-24 | Anton Cramer & Co, 4402 Greven | Daunen- und federndichtes Gewebe |
| DE2449885C3 (de) | 1974-10-21 | 1980-04-30 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat |
| US4001200A (en) | 1975-02-27 | 1977-01-04 | Alza Corporation | Novel polymerized, cross-linked, stromal-free hemoglobin |
| US4001401A (en) | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| JPS57206622A (en) | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
| US4529719A (en) | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| CA1312009C (en) | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| US5449759A (en) | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
| US5234903A (en) | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| US5650388A (en) | 1989-11-22 | 1997-07-22 | Enzon, Inc. | Fractionated polyalkylene oxide-conjugated hemoglobin solutions |
| US5585484A (en) * | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| DE69831248T2 (de) | 1997-02-28 | 2006-04-13 | The Regents Of The University Of California, Oakland | Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen |
| EP1121165A1 (en) * | 1998-10-15 | 2001-08-08 | Sangart, Inc. | Method for production of stroma-free hemoglobin |
| WO2003008932A2 (en) * | 2001-07-19 | 2003-01-30 | Albert Einstein College Of Medecine Of Yeshiva University | Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy akylene glycols |
| US20030153491A1 (en) * | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US7144989B2 (en) * | 2002-03-25 | 2006-12-05 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof |
| DE60336018D1 (de) * | 2002-12-23 | 2011-03-24 | Einstein Coll Med | Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren |
| CN1219811C (zh) * | 2003-01-22 | 2005-09-21 | 中国科学院过程工程研究所 | 带单甲氧基聚乙二醇长尾的蛋白质修饰剂及制法和用途 |
| WO2004076474A2 (en) * | 2003-02-26 | 2004-09-10 | Intermune, Inc. | Polyethylene glycol modified interferon compositions and methods of use thereof |
| ES2347805T3 (es) | 2004-08-31 | 2010-11-04 | Sangart, Inc. | Metodos para aumentar la estabilidad hemodinamica usando composiciones que transportan oxigeno. |
| US20060234915A1 (en) | 2005-03-07 | 2006-10-19 | Sangart, Inc. | Compositions and methods for delivering carbon monoxide (CO) and nitric oxide (NO) to tissue using heme proteins as carriers |
| WO2008136888A2 (en) * | 2007-03-13 | 2008-11-13 | Albert Einstein College Of Medicine Of Yeshiva University | Second generation low oxygen affinity pegylated hemoglobins as oxygen-carrying plasma expanders |
| US8021858B2 (en) | 2008-09-22 | 2011-09-20 | Sangart, Inc. | Method for making polyalkylene oxide modified hemoglobin |
| US20130041134A1 (en) | 2009-11-05 | 2013-02-14 | Sangart ,Inc. | Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material |
-
2011
- 2011-02-23 AU AU2011220885A patent/AU2011220885A1/en not_active Abandoned
- 2011-02-23 JP JP2012555105A patent/JP2013520512A/ja active Pending
- 2011-02-23 WO PCT/US2011/025888 patent/WO2011106396A1/en not_active Ceased
- 2011-02-23 US US13/579,656 patent/US9493616B2/en active Active
- 2011-02-23 CN CN2011800112675A patent/CN102859364A/zh active Pending
- 2011-02-23 CA CA2791122A patent/CA2791122C/en active Active
- 2011-02-23 EP EP11747978.2A patent/EP2539715B1/en active Active
- 2011-02-23 KR KR1020127025030A patent/KR20130067243A/ko not_active Withdrawn
-
2017
- 2017-09-19 AU AU2017232073A patent/AU2017232073B2/en active Active
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