JP2017537062A5 - - Google Patents
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- Publication number
- JP2017537062A5 JP2017537062A5 JP2017519672A JP2017519672A JP2017537062A5 JP 2017537062 A5 JP2017537062 A5 JP 2017537062A5 JP 2017519672 A JP2017519672 A JP 2017519672A JP 2017519672 A JP2017519672 A JP 2017519672A JP 2017537062 A5 JP2017537062 A5 JP 2017537062A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- group
- protein
- polyethylene glycol
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003153 chemical reaction reagent Substances 0.000 claims 14
- 239000002202 Polyethylene glycol Substances 0.000 claims 13
- 125000003827 glycol group Chemical group 0.000 claims 13
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 235000018102 proteins Nutrition 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000000032 diagnostic agent Substances 0.000 claims 4
- 229940039227 diagnostic agent Drugs 0.000 claims 4
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 101800001442 Peptide pr Proteins 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000468 ketone group Chemical group 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 229920002704 polyhistidine Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1418986.4A GB201418986D0 (en) | 2014-10-24 | 2014-10-24 | Novel conjugates and novel conjugating reagents |
| GBGB1418989.8A GB201418989D0 (en) | 2014-10-24 | 2014-10-24 | Novel conjugation process and reagents |
| GB1418989.8 | 2014-10-24 | ||
| GB1418986.4 | 2014-10-24 | ||
| GB1418984.9 | 2014-10-24 | ||
| GB1418984.9A GB2531715A (en) | 2014-10-24 | 2014-10-24 | Novel drug conjugates |
| PCT/GB2015/052953 WO2016063006A1 (en) | 2014-10-24 | 2015-10-08 | Conjugates and conjugating reagents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537062A JP2017537062A (ja) | 2017-12-14 |
| JP2017537062A5 true JP2017537062A5 (enExample) | 2018-11-22 |
| JP6612860B2 JP6612860B2 (ja) | 2019-11-27 |
Family
ID=54337308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519672A Active JP6612860B2 (ja) | 2014-10-24 | 2015-10-08 | コンジュゲート及びコンジュゲート試薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20170290925A1 (enExample) |
| EP (1) | EP3220956B1 (enExample) |
| JP (1) | JP6612860B2 (enExample) |
| KR (1) | KR102513926B1 (enExample) |
| CN (1) | CN107073131B (enExample) |
| AU (1) | AU2015334717B2 (enExample) |
| BR (1) | BR112017005760A2 (enExample) |
| CA (1) | CA2963043A1 (enExample) |
| ES (1) | ES2960741T3 (enExample) |
| IL (1) | IL250644B (enExample) |
| MX (1) | MX2017005199A (enExample) |
| RU (1) | RU2017108448A (enExample) |
| SG (1) | SG11201701342XA (enExample) |
| WO (1) | WO2016063006A1 (enExample) |
| ZA (1) | ZA201701337B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10098960B2 (en) | 2015-04-03 | 2018-10-16 | Ucl Business Plc | Polymer conjugate |
| JP2019506155A (ja) | 2016-01-12 | 2019-03-07 | クレッシェンド、バイオロジックス、リミテッドＣｒｅｓｃｅｎｄｏ Ｂｉｏｌｏｇｉｃｓ Ｌｉｍｉｔｅｄ | 治療分子 |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| CN109152845B (zh) | 2016-04-14 | 2022-07-12 | 宝力泰锐克斯有限公司 | 含有在环内包含至少两个(-ch2-ch2-o-)单元的接头的缀合物和缀合试剂 |
| GB201608936D0 (en) * | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| CN117534764A (zh) | 2016-06-06 | 2024-02-09 | 阿布泽纳(英国)有限公司 | 抗体、其用途及其缀合物 |
| GB201614162D0 (en) * | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| GB201615725D0 (en) | 2016-09-15 | 2016-11-02 | Polytherics Ltd | Novel cytotoxic agents and conjugates thereof |
| JP6990355B2 (ja) | 2017-03-30 | 2022-01-12 | 日油株式会社 | ヘテロ二官能性単分散ポリエチレングリコール及びそれを用いた複合体 |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| KR102542988B1 (ko) | 2018-03-13 | 2023-06-13 | 니치유 가부시키가이샤 | 주쇄 및 측쇄에 단분산 폴리에틸렌 글리콜을 가지는 헤테로이관능성 화합물 |
| EP3789401A1 (en) | 2019-09-03 | 2021-03-10 | Gamamabs Pharma | Amhrii-binding antibody drug conjugates and their use thereof in the treatment of cancers |
| AU2021262526A1 (en) * | 2020-04-29 | 2022-11-03 | Araclon Biotech, S.L. | Methods for quantification of amyloid beta peptides in plasma by mass spectrometry |
| GB2594753B (en) | 2020-05-27 | 2022-05-18 | Spirea Ltd | Antibody-drug conjugates |
| EP4404974A1 (en) | 2021-09-21 | 2024-07-31 | Spirea Limited | Antibody-drug conjugates |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| CA2323048C (en) * | 1998-03-12 | 2006-10-10 | Shearwater Polymers, Inc. | Poly(ethylene glycol) derivatives with proximal reactive groups |
| KR100511749B1 (ko) * | 2001-11-06 | 2005-09-02 | 선바이오(주) | 변형된 인터페론-베타, 및 이의 화학적으로 변형된 배합체 |
| ES2605443T3 (es) * | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| EP1909846B1 (en) * | 2005-08-05 | 2018-12-26 | Syntarga B.V. | Triazole-containing releasable linkers, conjugates comprising the same and processes for their preparation |
| US20070141134A1 (en) * | 2005-12-16 | 2007-06-21 | Kosak Matthew K | Shielded micelles for polynucleotide delivery |
| MX2009002855A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales. |
| EP2118150B1 (en) * | 2007-02-14 | 2015-09-23 | Biocompatibles UK Limited | Derivatisation of biological molecules |
| GB0922354D0 (en) * | 2009-12-21 | 2010-02-03 | Polytherics Ltd | Novel polymer conjugates |
| CN104906592B (zh) * | 2011-02-25 | 2017-11-03 | 广州南沙龙沙有限公司 | 用于蛋白质药物偶联物的支链联接体 |
| EP2678037B1 (en) * | 2011-02-25 | 2014-12-03 | Lonza Ltd | Branched linker for protein drug conjugates |
| GB201210770D0 (en) * | 2012-06-18 | 2012-08-01 | Polytherics Ltd | Novel conjugation reagents |
| US9650331B2 (en) * | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| BR112014031613A2 (pt) * | 2012-06-19 | 2017-07-25 | Polytherics Ltd | processo para preparação de conjugados de anticorpos e conjugados de anticorpos |
| NO2789793T3 (enExample) * | 2012-10-24 | 2018-01-27 | ||
| ES2623209T3 (es) * | 2012-10-24 | 2017-07-10 | Polytherics Limited | Conjugados fármaco-proteína |
| PT3057585T (pt) * | 2013-10-15 | 2020-10-21 | Seagen Inc | Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando |
-
2015
- 2015-10-08 EP EP15782051.5A patent/EP3220956B1/en active Active
- 2015-10-08 MX MX2017005199A patent/MX2017005199A/es unknown
- 2015-10-08 ES ES15782051T patent/ES2960741T3/es active Active
- 2015-10-08 RU RU2017108448A patent/RU2017108448A/ru unknown
- 2015-10-08 CA CA2963043A patent/CA2963043A1/en not_active Abandoned
- 2015-10-08 SG SG11201701342XA patent/SG11201701342XA/en unknown
- 2015-10-08 BR BR112017005760A patent/BR112017005760A2/pt not_active Application Discontinuation
- 2015-10-08 KR KR1020177010432A patent/KR102513926B1/ko active Active
- 2015-10-08 US US15/517,969 patent/US20170290925A1/en not_active Abandoned
- 2015-10-08 WO PCT/GB2015/052953 patent/WO2016063006A1/en not_active Ceased
- 2015-10-08 CN CN201580057559.0A patent/CN107073131B/zh active Active
- 2015-10-08 AU AU2015334717A patent/AU2015334717B2/en active Active
- 2015-10-08 JP JP2017519672A patent/JP6612860B2/ja active Active
-
2017
- 2017-02-16 IL IL250644A patent/IL250644B/en active IP Right Grant
- 2017-02-22 ZA ZA2017/01337A patent/ZA201701337B/en unknown
-
2020
- 2020-03-03 US US16/807,298 patent/US20200268885A1/en active Pending
-
2024
- 2024-03-19 US US18/609,210 patent/US20240293549A1/en active Pending
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