MX2010005813A - Conjugados oligomero-triciclicos. - Google Patents

Conjugados oligomero-triciclicos.

Info

Publication number
MX2010005813A
MX2010005813A MX2010005813A MX2010005813A MX2010005813A MX 2010005813 A MX2010005813 A MX 2010005813A MX 2010005813 A MX2010005813 A MX 2010005813A MX 2010005813 A MX2010005813 A MX 2010005813A MX 2010005813 A MX2010005813 A MX 2010005813A
Authority
MX
Mexico
Prior art keywords
oligomer
tricyclic
conjugates
water soluble
small molecule
Prior art date
Application number
MX2010005813A
Other languages
English (en)
Inventor
Jennifer Riggs-Sauthier
Wen Zhang
Xuyuan Gu
Stephanie Allums
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of MX2010005813A publication Critical patent/MX2010005813A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)

Abstract

La invención proporciona fármacos de moléculas pequeñas que están modificados químicamente por unión covalente de un oligómero soluble en agua; un conjugado de la invención, cuando se administra por cualquiera de varias rutas de administración, exhibe características que son diferentes de las características del fármaco de molécula pequeña no unido al oligómero soluble en agua.
MX2010005813A 2007-11-28 2008-11-28 Conjugados oligomero-triciclicos. MX2010005813A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US448307P 2007-11-28 2007-11-28
US19163508P 2008-09-10 2008-09-10
PCT/US2008/013221 WO2009073154A1 (en) 2007-11-28 2008-11-28 Oligomer-tricyclic conjugates

Publications (1)

Publication Number Publication Date
MX2010005813A true MX2010005813A (es) 2010-06-15

Family

ID=40342742

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005813A MX2010005813A (es) 2007-11-28 2008-11-28 Conjugados oligomero-triciclicos.

Country Status (11)

Country Link
US (2) US8569380B2 (es)
EP (1) EP2222342B1 (es)
JP (1) JP5643103B2 (es)
KR (1) KR101539797B1 (es)
CN (1) CN101878042B (es)
AU (1) AU2008331868B2 (es)
CA (1) CA2704836C (es)
HK (1) HK1147212A1 (es)
IL (1) IL205966A (es)
MX (1) MX2010005813A (es)
WO (1) WO2009073154A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8796248B2 (en) * 2007-10-05 2014-08-05 Nektar Therapeutics Oligomer-corticosteroid conjugates
MX2010005813A (es) 2007-11-28 2010-06-15 Nektar Therapeutics Conjugados oligomero-triciclicos.
WO2011091050A1 (en) * 2010-01-19 2011-07-28 Nektar Therapeutics Oligomer-tricyclic conjugates
EP2648707B1 (en) * 2010-12-10 2016-05-11 Nektar Therapeutics Hydroxylated tricyclic compounds
WO2012088529A1 (en) 2010-12-23 2012-06-28 Nektar Therapeutics Polymer-sunitinib conjugates
WO2012088522A1 (en) 2010-12-23 2012-06-28 Nektar Therapeutics Polymer-des-ethyl sunitinib conjugates
CN105085465A (zh) * 2015-08-17 2015-11-25 苏州黄河制药有限公司 一种以邻卤甲基苯甲酸甲酯为原料合成盐酸多塞平的方法
CN105367538A (zh) * 2015-11-26 2016-03-02 苏州黄河制药有限公司 一种以邻卤甲基苯甲酸甲酯为原料制备盐酸多塞平的方法
CA3062738C (en) 2016-05-02 2023-03-14 James Roy Brownlee Replaceable absorbent diaper channel for use as a multiplier with single-use disposable diapers or re-usable recyclable outer shell
CA3154630A1 (en) 2019-10-21 2021-04-29 Mark E. Duggan 3-(4-(11h-dibenzo[b,e][1,4]azepin-6-yl)piperazin-1-yl)- and 3-(4-(dibenzo[b,f][1,4]oxazepin/thiazepin/diazepin-11-yl)piperazin-1-yl)-propano ic acid derivatives as h1 and 5-ht2a-receptor modulators for the treatment of sleep disorders
CN110698451A (zh) * 2019-10-29 2020-01-17 山东诚汇双达药业有限公司 取代二苯并[ b，e ]硫（氧）杂七环-11（6H）-酮类化合物及其制备方法
CN112410385B (zh) * 2020-11-24 2022-07-22 江南大学 一种细胞色素p450环氧酶及其应用
CN114702453B (zh) * 2022-03-29 2024-02-02 江西师范大学 11-(三氟甲基)-二苯并[b,e][1,4]二氮杂卓系列化合物及其制备方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2948718A (en) * 1960-08-09 New n-heterocyclic compounds
US2554736A (en) * 1951-05-29 Tertiary aminoalkyl-iminodibenzyls
US3282942A (en) * 1966-11-01 Substituted cycloalkanoindoles
CH368178A (de) 1958-09-10 1963-03-31 Geigy Ag J R Verfahren zur Herstellung von neuen basisch substituierten heterocyclischen Verbindungen
NL110232C (es) * 1958-12-06
US3409640A (en) * 1959-07-22 1968-11-05 Schering Corp 5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes
NL256049A (es) 1959-09-22
NL274885A (es) * 1960-09-16
US3454554A (en) * 1960-10-14 1969-07-08 Colgate Palmolive Co Aminoalkyliminodibenzyl compounds
NL279409A (es) * 1961-06-08
CH426833A (de) * 1962-03-27 1966-12-31 Dumex Ltd As Verfahren zur Herstellung des N-Oxyds des N-(3-Dimethylamino-propyl)-iminodibenzyls oder seiner Salze
US3205264A (en) * 1962-06-15 1965-09-07 Merck & Co Inc Process for the preparation of 10, 11-dihydro-5-(gamma-methyl-and dimethyl-amino propylidene)-5h-dibenzo[a, d] cycloheptene
US3271451A (en) * 1962-07-03 1966-09-06 Merck & Co Inc Process for preparing 5-(3-methylaminopropyl)-5h-dibenzo [a, d] cycloheptenes
US3244748A (en) * 1962-07-03 1966-04-05 Merck & Co Inc 5h-dibenzo [a, d] cycloheptenes
NL130095C (es) * 1962-08-31
US3258399A (en) * 1962-09-13 1966-06-28 Colgate Palmolive Co Method of inducing central nervous system stimulation
US3420851A (en) * 1962-12-19 1969-01-07 Pfizer & Co C Novel dibenzoxepines
GB991651A (en) * 1963-02-20 1965-05-12 Dumex Ltd As Dibenzocycloheptadiene derivatives
FR88751E (es) * 1963-07-09 1967-06-07
CH433303A (de) 1963-08-05 1967-04-15 Sandoz Ag Verfahren zur Herstellung neuer carbocyclischer Verbindungen
US3452009A (en) * 1965-05-03 1969-06-24 Merck & Co Inc 2,3-epoxypropylidene derivative of 5h-dibenzo(a,d)-10,11-dihydrocycloheptenes
US3963778A (en) * 1965-11-10 1976-06-15 Bayer Aktiengesellschaft Basic oximes and their preparation
GB1192812A (en) * 1966-05-20 1970-05-20 American Cyanamid Co 2-Chloro-11-(1-Piperazinyl)Dibenz[b,f]-[1,4]Oxazepine, Non-Toxic Acid Addition Salts thereof, and Therapeutic Compositions containing said Oxazepine or Salts
FR1532301A (fr) * 1967-01-18 1968-07-12 Rhone Poulenc Sa Nouveaux dérivés de la dibenzazépine et leur préparation
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest
GB1191800A (en) 1968-12-10 1970-05-13 Nii Farmakologii I Khim 00-(beta-Diethylaminopropionyl)-2-Trifluoromethylphenothiazine Hydrochloride
CH500196A (de) * 1969-03-10 1970-12-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Azepinderivaten
GB1269551A (en) 1969-03-27 1972-04-06 Science Union & Cie New tricyclic derivatives and process for their manufacture
US3758528A (en) * 1970-03-13 1973-09-11 Science Union & Cie Tricyclic compounds
US4250094A (en) * 1971-04-28 1981-02-10 The Upjohn Company 1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
US4097597A (en) * 1977-02-23 1978-06-27 Abbott Laboratories Dibenzo b,e! 1,4!diazepines
ATE13297T1 (de) * 1980-09-02 1985-06-15 Sandoz Ag Piperidyliden-derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US5783178A (en) 1994-11-18 1998-07-21 Supratek Pharma. Inc. Polymer linked biological agents
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US6214820B1 (en) * 1998-10-21 2001-04-10 Novo Nordisk A/S Compounds, their preparation and use
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
AR047938A1 (es) 2003-08-25 2006-03-15 Combinatorx Inc Formulaciones, conjugados y combinaciones de farmacos para el tratamiento de neoplasmas
WO2005058367A2 (en) 2003-12-16 2005-06-30 Nektar Therapeutics Al, Corporation Pegylated small molecules
CA2556380A1 (en) * 2004-03-02 2005-09-15 Pharmacia Corporation Methods and compositions for treating or preventing psychiatric disorders with cox-2 inhibitors alone and in combination with antidepressant agents
CA2597306A1 (en) 2005-02-14 2006-08-24 Combinatorx, Incorporated Compounds and uses thereof
US8029355B2 (en) * 2006-12-19 2011-10-04 Igt Configurable gaming device with player selectable award profile
TW200836747A (en) 2007-01-05 2008-09-16 Combinatorx Inc Methods, compositions, and kits for the treatment of pain
US8389759B2 (en) * 2007-03-12 2013-03-05 Nektar Therapeutics Oligomer-anticholinergic agent conjugates
MX2010005813A (es) 2007-11-28 2010-06-15 Nektar Therapeutics Conjugados oligomero-triciclicos.
WO2009151590A2 (en) 2008-06-09 2009-12-17 Nektar Therapeutics Methods of treating cyp2d6 alternative metabolizers
CA2749126C (en) 2009-01-28 2017-08-22 Nektar Therapeutics Oligomer-phenothiazine conjugates

Also Published As

Publication number Publication date
US9725431B2 (en) 2017-08-08
IL205966A0 (en) 2010-11-30
CN101878042B (zh) 2013-06-19
CN101878042A (zh) 2010-11-03
CA2704836A1 (en) 2009-06-04
US8569380B2 (en) 2013-10-29
US20140100268A1 (en) 2014-04-10
HK1147212A1 (en) 2011-08-05
JP5643103B2 (ja) 2014-12-17
EP2222342B1 (en) 2014-03-26
EP2222342A1 (en) 2010-09-01
US20100298296A1 (en) 2010-11-25
AU2008331868A1 (en) 2009-06-11
WO2009073154A1 (en) 2009-06-11
JP2011504928A (ja) 2011-02-17
CA2704836C (en) 2015-12-29
KR20100093059A (ko) 2010-08-24
KR101539797B1 (ko) 2015-07-27
AU2008331868B2 (en) 2015-02-12
IL205966A (en) 2014-11-30

Similar Documents

Publication Publication Date Title
MX2010005813A (es) Conjugados oligomero-triciclicos.
MX2009009851A (es) Conjugados de agonistas de oligomeros-opioides.
MX2009009850A (es) Conjugados de inhibidor de oligomero-proteasa.
WO2009042064A3 (en) Oligomer-nucleoside phosphate conjugates
CY1112278T1 (el) Κυτταροτοξικοι παραγοντες που περιεχουν νεα παραγωγα τομαυμυciν και η θεραπευτικη χρηση τους
WO2005058367A3 (en) Pegylated small molecules
WO2009099670A3 (en) Oligomer-cannabinoid conjugates
NZ720743A (en) Peptidomimetic compounds and antibody-drug conjugates thereof
ATE524473T1 (de) Zytotoxische verbindungen
NZ754810A (en) Pyrrolobenzodiazepine-antibody conjugates
WO2007103288A3 (en) Engineered antibody drug conjugates
WO2007130491A3 (en) Patient customized therapeutic regimens
WO2008112873A3 (en) Binding ligand linked drug delivery conjugates of tubulysins
MY197127A (en) Pyrrolobenzodiazepine conjugates
WO2007137170A3 (en) Anti-glypican-3 antibody drug conjugates
PT2057139E (pt) Derivados de sulfureto de hidrogénio de fármacos antiinflamatórios não esteroidais
WO2011002852A3 (en) Pro-drug complexes and related methods of use
WO2016147031A3 (en) Novel hydrophilic linkers and ligand-drug conjugates thereof
WO2011054837A3 (de) Bifunktionale prodrugs und drugs
CA3010551A1 (en) Pyrrolobenzodiazepine conjugates
MX2012010448A (es) Conjugados de carbohidrato-poli aminoacido-farmaco.
EA200900958A1 (ru) Препарат невирапина пролонгированного высвобождения
WO2009058387A3 (en) Oligomer-nitroimidazole anti-infective conjugates
MX2011007940A (es) Conjugados de oligomero-fenotiazina.
UA102216C2 (ru) 4-гидрокситиобензамидные производной лекарственных веществ

Legal Events

Date Code Title Description
FG Grant or registration